Aliases & Classifications for Hemarthrosis

MalaCards integrated aliases for Hemarthrosis:

Name: Hemarthrosis 12 54 44 15 17 71
Hemarthrosis Involving Pelvic Region and Thigh 12
Haemarthrosis of the Pelvic Region and Thigh 12
Hemarthrosis of the Pelvic Region and Thigh 12
Hemarthrosis Involving Shoulder Region 12
Hemarthrosis Involving Ankle and Foot 12
Hemarthrosis of the Ankle and/or Foot 12
Haemarthrosis of the Ankle and Foot 12
Hemarthrosis of the Shoulder Region 12
Hemarthrosis of the Ankle and Foot 12
Hemarthrosis of Ankle and/or Foot 12
Hemarthrosis Involving Lower Leg 12
Hemarthrosis Involving Upper Arm 12
Haemarthrosis of Shoulder Joint 12
Hemarthrosis of Shoulder Region 12
Hemarthrosis Involving Forearm 12
Hemarthrosis of the Lower Leg 12
Hemarthrosis of the Upper Arm 12
Hemarthrosis Involving Hand 12
Hemarthrosis of the Forearm 12
Hemarthrosis of Lower Leg 12
Hemarthrosis of Upper Arm 12
Hemarthrosis of Shoulder 12
Hemarthrosis of the Hand 12
Hemarthrosis of Forearm 12
Hemarthrosis of Hand 12

Classifications:



External Ids:

Disease Ontology 12 DOID:801
ICD9CM 34 719.1
MeSH 44 D006395
SNOMED-CT 67 156581006
ICD10 32 M25.0
UMLS 71 C0018924

Summaries for Hemarthrosis

MalaCards based summary : Hemarthrosis, also known as hemarthrosis involving pelvic region and thigh, is related to hemophilia and factor vii deficiency, and has symptoms including arthralgia, hemoptysis and metatarsalgia. An important gene associated with Hemarthrosis is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. The drugs Triamcinolone and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and spinal cord, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Hemarthrosis is a bleeding into joint spaces. It is a common feature of... more...

Related Diseases for Hemarthrosis

Diseases related to Hemarthrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 hemophilia 31.1 F9 F8 F7
2 factor vii deficiency 30.9 F9 F8 F7 F3 F2 F10
3 factor x deficiency 30.9 F9 F7 F3 F2 F11 F10
4 glanzmann thrombasthenia 30.8 VWF F9 F8 F7 F3 F10
5 arthropathy 30.7 F9 F8 ACAN
6 thrombasthenia 30.3 F3 F2
7 hemangioma 30.3 VWF F3 F2
8 afibrinogenemia, congenital 30.2 VWF F8 F7 F3 F2 F11
9 hemophilia a 30.1 VWF F9 F8 F7 F3
10 purpura 30.0 VWF F3 F2
11 synovial angioma 29.9 F8 F7 F3 F2
12 angiodysplasia 29.8 VWF F8 F3
13 factor v deficiency 29.7 VWF MCFD2 F9 F8 F7 F3
14 acquired hemophilia 29.7 F9 F8 F3 F11 F10
15 acquired hemophilia a 29.7 F9 F8 F3 F11
16 acute myocardial infarction 29.7 VWF F7 F3
17 factor xiii deficiency 29.7 VWF MCFD2 F8 F7 F3 F2
18 essential thrombocythemia 29.5 VWF F3 F2
19 vascular disease 29.2 VWF SPP1 F8 F3 F2
20 vitamin k deficiency bleeding 28.9 F9 F8 F7 F3 F2 BGLAP
21 disseminated intravascular coagulation 28.9 VWF F9 F7 F3 F2 F10
22 thrombophilia due to thrombin defect 28.8 VWF F8 F3 F2 F13B F10
23 von willebrand's disease 28.7 VWF F9 F8 F7 F3 F2
24 factor xi deficiency 28.6 VWF F9 F8 F7 F3 F2
25 hemophilia b 28.6 VWF F9 F8 F7 F3 F2
26 factor viii deficiency 28.4 VWF MCFD2 F9 F8 F7 F3
27 thrombophilia 28.3 VWF F9 F8 F7 F3 F2
28 myocardial infarction 28.3 VWF F9 F8 F7 F3 F2
29 thrombocytopenia 27.6 VWF MCFD2 F9 F8 F7 F3
30 hemorrhagic disease 27.3 VWF MCFD2 F9 F8 F7 F3
31 plica syndrome 10.4
32 synovitis 10.4
33 fainting 10.3 VWF F8
34 pediatric angiosarcoma 10.3 VWF F8
35 hemophilic arthropathy 10.3
36 breast hemangioma 10.3 VWF F8
37 heparin-induced thrombocytopenia 10.3 F3 F10
38 thyroid angiosarcoma 10.3 VWF F8
39 wiedemann-rautenstrauch syndrome 10.3 SPP1 BGLAP
40 lymphangiosarcoma 10.3 VWF F8
41 leech infestation 10.3 F3 F10
42 papillary cystadenocarcinoma 10.3 SPP1 BGLAP
43 medulloadrenal hyperfunction 10.3 VWF F3
44 thrombotic microangiopathy 10.3 VWF F3
45 von willebrand disease, type 2 10.2 VWF F8
46 tooth resorption 10.2 SPP1 BGLAP
47 von willebrand disease, type 3 10.2 VWF F8
48 osteogenesis imperfecta, type vii 10.2 SPP1 BGLAP
49 adhesive otitis media 10.2 F9 F7
50 prothrombin deficiency, congenital 10.2 F2 F10

Graphical network of the top 20 diseases related to Hemarthrosis:



Diseases related to Hemarthrosis

Symptoms & Phenotypes for Hemarthrosis

UMLS symptoms related to Hemarthrosis:


arthralgia, hemoptysis, metatarsalgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

MGI Mouse Phenotypes related to Hemarthrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 F10 F11 F2 F3 F7 F9
2 homeostasis/metabolism MP:0005376 9.4 BGLAP F10 F11 F13B F2 F3

Drugs & Therapeutics for Hemarthrosis

Drugs for Hemarthrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Tranexamic Acid Approved Phase 4 1197-18-8 5526
5 Hylan Phase 4
6 Triamcinolone hexacetonide Phase 4
7 triamcinolone acetonide Phase 4
8 Triamcinolone diacetate Phase 4
9 Hemostatics Phase 4
10 Coagulants Phase 4
11 Antifibrinolytic Agents Phase 4
12 Pharmaceutical Solutions Phase 4
13
Bevacizumab Approved, Investigational Phase 1 216974-75-3
14 Angiogenesis Inhibitors Phase 1
15 Antineoplastic Agents, Immunological Phase 1
16
Povidone-iodine Approved 25655-41-8
17
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
18 Chlorhexidine gluconate
19 Factor VIII
20 Brimonidine Tartrate 70359-46-5

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Reducing Hemarthrosis in Anterior Cruciate Ligament Reconstruction With BTB Autograft by the Administration of Intravenous Tranexamic Acid: A Double-Blind Randomized Control Study Completed NCT03631355 Phase 4 Tranexamic Acid
2 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
3 Reducing Hemarthrosis in Tibial Tubercle Osteotomy by the Administration of Intravenous Tranexamic Acid Recruiting NCT03606109 Phase 4 Tranexamic Acid (TXA)
4 Intra-articular Administration of 3.0g Tranexamic Acid Has no Effect on Reducing Intra-articular Hemarthrosis and Postoperative Pain After Primary Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial Active, not recruiting NCT04042688 Phase 4 intraarticular administration of tranexamic acid
5 A Pilot Study About the Safety and Efficacy of Intra-articular Bevacizumab (Avastin) for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Recruiting NCT02060305 Phase 1 Bevacizumab intra-articular injection
6 Aspiration for Pain Relief Following Ankle Fracture: A Prospective Double-Blind Randomized Controlled Trial Completed NCT01484535
7 Intraarticular Injection of Tranexamic Acid Reduced Postoperative Hemarthrosis in Arthroscopic Anterior Cruciate Ligament Reconstruction - A Prospective Randomized Study Completed NCT03580018 Tranexamic Acid Powder
8 Efficacy of Peroperative Suction Drain Usage in Arthroscopic Knee Surgery Completed NCT02752581
9 Ultrasonography in Hemophilic Joint Disease Completed NCT02634918
10 Effects of COVID-19 Quarantine on the Musculoskeletal Status of Adult Hemophilia Patients. An Observational Study Recruiting NCT04491318
11 Handheld Ultrasound (HHUS) for Home Use in Hemophilia Recruiting NCT04131920

Search NIH Clinical Center for Hemarthrosis

Cochrane evidence based reviews: hemarthrosis

Genetic Tests for Hemarthrosis

Anatomical Context for Hemarthrosis

MalaCards organs/tissues related to Hemarthrosis:

40
Bone, Liver, Spinal Cord, Skeletal Muscle, Prostate, Myeloid, B Cells

Publications for Hemarthrosis

Articles related to Hemarthrosis:

(show top 50) (show all 1022)
# Title Authors PMID Year
1
Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX. 54 61
18716130 2008
2
Von Willebrand's disease in the year 2003: towards the complete identification of gene defects for correct diagnosis and treatment. 61 54
12551832 2003
3
Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T2 Mapping. 61
33135834 2021
4
Management and Complications in Nonoperative Fractures of the Tibial Spine: A Systematic Review. 61
33448724 2021
5
Clinical Outcomes and Experience of a Multiyear Consecutive Case Series of Total Knee Arthroplasty Procedures Conducted with a Bipolar Sealer System for Hemostasis. 61
33607677 2021
6
[Radial head fractures : Epidemiology, diagnosis, treatment and outcome]. 61
33443629 2021
7
Systemic Vascular Basement Membrane Markers Linked to Synovial Vascular Remodeling are Biomarkers of Hemarthrosis in Patients with Hemophilia. 61
33587779 2021
8
Synovial fluid analysis with leukocyte esterase reagent strip test. 61
33527167 2021
9
Knee radiosynovectomy with 153Sm-hydroxyapatite compared to 90Y-hydroxyapatite: initial results of a prospective trial. 61
33389651 2021
10
Novel treatments for hemophilia through rebalancing of the coagulation cascade. 61
33577709 2021
11
The effectiveness of manual therapy in addition to passive stretching exercises in the treatment of patients with haemophilic knee arthropathy: A randomized, single-blind clinical trial. 61
33094898 2021
12
Tranexamic Acid in Foot and Ankle Surgery: A Topical Review and Value Analysis. 61
33401927 2021
13
Imaging appearances of giant cell tumor of the bone. 61
33487877 2021
14
The comparative efficacies of intravenous administration and intra-articular injection of tranexamic acid during anterior cruciate ligament reconstruction for reducing postoperative hemarthrosis: a prospective randomized study. 61
33499848 2021
15
Tranexamic Acid Has No Effect on Post-operative Hemarthrosis or Pain Control Following ACL Reconstruction Using Bone Patella Tendon Bone Autograft: A Double-Blinded Randomized Control Trial. 61
33529783 2021
16
Arthroscopic versus Open Osteochondral Autograft Transplantation (Mosaicplasty) for Cartilage Damage of the Knee: A Systematic Review. 61
31288271 2021
17
Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques. 61
33307179 2020
18
Magnetic Resonance Imaging of Hemophilic Joints: Correlations with the Bleeding Phenotype and Physical Examination. 61
33415922 2020
19
Those with hemophilia or von Willebrand disease do not have increased perioperative complications following anterior cruciate ligament reconstruction: Results of a case-control large-database study. 61
33197811 2020
20
Decreased Platelet Surface Phosphatidylserine Predicts Increased Bleeding in Patients with Severe Factor VIII Deficiency. 61
33370471 2020
21
Tranexamic Acid Use in Knee and Shoulder Arthroscopy Leads to Improved Outcomes and Fewer Hemarthrosis-Related Complications: A Systematic Review of Level I and II Studies. 61
33278534 2020
22
Angiosarcoma after revision total knee arthroplasty. 61
33360381 2020
23
HIV-Positive Patients Are at Increased Risk of Venous Thromboembolism After Total Joint Replacement. 61
33252548 2020
24
Unique inflammatory signature in haemophilic arthropathy: miRNA changes due to interaction between blood and fibroblast-like synoviocytes. 61
33159500 2020
25
Evolving evidence in the treatment of primary and recurrent posterior cruciate ligament injuries, part 1: anatomy, biomechanics and diagnostics. 61
33201271 2020
26
The Safety of Genicular Nerve Radiofrequency Ablation. 61
33517427 2020
27
Functionality and range of motion in patients with hemophilic ankle arthropathy treated with fascial therapy. A randomized clinical trial. 61
32861358 2020
28
Outcomes in children with hemophilia A with inhibitors: Results from a noninterventional study. 61
32776489 2020
29
Complications of hemophilia in the elbow: current management. 61
32723183 2020
30
Bleeding symptoms in patients diagnosed as type 3 von Willebrand disease: Results from 3WINTERS-IPS, an international and collaborative cross-sectional study. 61
32379400 2020
31
Temporomandibular joint alloplastic reconstruction of post-traumatic joint degeneration with Sawhney Type I ankylosis using 3D-custom GD-condylar cap prosthesis to restore condylar form and function. 61
32977036 2020
32
Naproxen-induced thrombocytopenia. 61
33100559 2020
33
Endovascular management of recurrent hemarthrosis of the knee: a case series. 61
32864716 2020
34
Intra-articular Administration of Tranexamic Acid Has No Effect in Reducing Intra-articular Hemarthrosis and Postoperative Pain After Primary ACL Reconstruction Using a Quadruple Hamstring Graft: A Randomized Controlled Trial. 61
32743011 2020
35
A Review of Current Management of Knee Hemarthrosis in the Non-Hemophilic Population. 61
32698601 2020
36
Needle arthroscopy of the radiocarpal and middle carpal joints in standing sedated horses. 61
32333682 2020
37
Safe Distraction Technique for Hip Arthroscopy in a Polytraumatized Patient with Pelvic, Acetabular, and Ankle Fractures: A Case Report. 61
32910615 2020
38
A Novel Case of Recurrent Hemarthrosis Following Knee Arthroscopy in a Patient with Undiagnosed Hemophilia. 61
32548594 2020
39
Embolization for intractable spontaneous hemarthrosis of the knee joint in the elderly patient: Case report. 61
32541469 2020
40
EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice. 61
32294155 2020
41
Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice. 61
32613175 2020
42
No longer a historical ailment: two cases of childhood scurvy with recommendations for bone health providers. 61
31901946 2020
43
Traditional investigation and management for recurrent hemarthrosis after total knee arthroplasty: A case report. 61
32518788 2020
44
MR Features of Juxta-Articular Venous Malformations of the Knee to Predict the Clinical Outcome of Sclerotherapy. 61
31882302 2020
45
Diagnostic needle arthroscopy of the tarsocrural joint in standing sedated horses. 61
31943288 2020
46
Radiosynovectomy is a safe and an efficient alternative in the treatment of chronic, recurrent knee hemarthrosis. 61
32939210 2020
47
Tranexamic acid is effective in decreasing postoperative intraarticular bleeding in arthroscopic knee surgery. 61
31990755 2020
48
Treatment with radiosynoviorthesis in hemophilic patients with and without inhibitor. 61
32312235 2020
49
[A rare differential diagnosis of "atraumatic" shoulder pain]. 61
32067072 2020
50
A Unique Presentation of Spontaneous Compartment Syndrome due to Acquired Hemophilia A and Associated Malignancy: Case Report and Literature Review. 61
32284775 2020

Variations for Hemarthrosis

Expression for Hemarthrosis

Search GEO for disease gene expression data for Hemarthrosis.

Pathways for Hemarthrosis

Pathways related to Hemarthrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 MCFD2 F9 F8 F7 F2 F10
2
Show member pathways
13.05 VWF F9 F8 F7 F3 F2
3
Show member pathways
12.59 F9 F8 F7 F3 F2 F13B
4
Show member pathways
11.81 VWF F9 F8 F7 F3 F2
5
Show member pathways
11.8 F9 F7 F2 F10 BGLAP
6 11.56 SPP1 BGLAP ACAN
7 11.44 VWF F9 F8 F7 F3 F2
8 10.73 F9 F7 F2 F10 BGLAP

GO Terms for Hemarthrosis

Cellular components related to Hemarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 VWF SPP1 F9 F8 F7 F3
2 collagen-containing extracellular matrix GO:0062023 9.8 VWF F9 F7 F3 F2 ACAN
3 extracellular region GO:0005576 9.73 VWF SPP1 F9 F8 F7 F3
4 endoplasmic reticulum lumen GO:0005788 9.7 SPP1 F9 F8 F7 F2 F10
5 vesicle GO:0031982 9.61 SPP1 F7 BGLAP
6 intrinsic component of external side of plasma membrane GO:0031233 9.4 F3 F10
7 serine-type peptidase complex GO:1905286 9.37 F7 F3
8 Golgi lumen GO:0005796 9.1 F9 F7 F2 F10 BGLAP ACAN

Biological processes related to Hemarthrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 F9 F7 F2 F11 F10 ACAN
2 ER to Golgi vesicle-mediated transport GO:0006888 9.8 MCFD2 F9 F8 F7 F2 F10
3 positive regulation of protein kinase B signaling GO:0051897 9.71 F7 F3 F10
4 platelet activation GO:0030168 9.67 VWF F8 F2
5 hemostasis GO:0007599 9.61 VWF F9 F8 F7 F3 F2
6 blood coagulation, intrinsic pathway GO:0007597 9.55 VWF F9 F8 F2 F11
7 response to vitamin D GO:0033280 9.52 SPP1 BGLAP
8 positive regulation of blood coagulation GO:0030194 9.51 F7 F2
9 blood coagulation, extrinsic pathway GO:0007598 9.5 F7 F3 F10
10 regulation of blood coagulation GO:0030193 9.48 F2 F11
11 positive regulation of positive chemotaxis GO:0050927 9.46 F7 F3
12 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.43 F7 F3
13 response to vitamin K GO:0032571 9.4 F7 BGLAP
14 blood coagulation GO:0007596 9.28 VWF F9 F8 F7 F3 F2

Molecular functions related to Hemarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.7 MCFD2 F9 F7 F2 F10 BGLAP
2 peptidase activity GO:0008233 9.65 F9 F7 F2 F11 F10
3 serine-type peptidase activity GO:0008236 9.35 F9 F7 F2 F11 F10
4 serine-type endopeptidase activity GO:0004252 9.1 F9 F7 F3 F2 F11 F10

Sources for Hemarthrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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