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MCID: HMT018
MIFTS: 57

Hematopoietic Stem Cell Transplantation

Categories: Rare diseases, Blood diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Hematopoietic Stem Cell Transplantation

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MalaCards integrated aliases for Hematopoietic Stem Cell Transplantation:

Name: Hematopoietic Stem Cell Transplantation 38 59

Characteristics:

Orphanet epidemiological data:

59
hematopoietic stem cell transplantation
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Orphanet 59 ORPHA90053
ICD10 via Orphanet 34 Z94.8
Sources

Summaries for Hematopoietic Stem Cell Transplantation

About this section
MalaCards based summary : Hematopoietic Stem Cell Transplantation is related to aspergillosis and chronic active epstein-barr virus infection. An important gene associated with Hematopoietic Stem Cell Transplantation is ARHGAP45 (Rho GTPase Activating Protein 45), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Micafungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, myeloid and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem... more...

Sources

Related Diseases for Hematopoietic Stem Cell Transplantation

About this section

Diseases related to Hematopoietic Stem Cell Transplantation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 626)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 32.7 CLEC7A IFNG IL10
2 chronic active epstein-barr virus infection 31.7 CTLA4 IFNG IL10 IL2
3 cytomegalovirus retinitis 30.8 HLA-B IFNG TNF
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 CTLA4 IFNG IL10
5 pure red-cell aplasia 30.7 HLA-A HLA-B IL2
6 post-transplant lymphoproliferative disease 30.7 IL10 IL6 TNF
7 hemophagocytic lymphohistiocytosis 30.6 IFNG IL10 TNF
8 pneumonia 30.6 IL10 IL6 TNF
9 bronchiolitis obliterans 30.6 IFNG IL10 IL6 TNF
10 bronchiolitis 30.5 IFNG IL10 IL6 TNF
11 acute graft versus host disease 30.4 ARHGAP45 IFNG IL10 IL2 TNF
12 relapsing-remitting multiple sclerosis 30.4 IFNG IL10 TNF
13 omenn syndrome 30.3 IFNG IL10 TNF
14 trichosporonosis 30.3 IFNG TNF
15 severe cutaneous adverse reaction 30.3 HLA-A HLA-B HLA-C
16 candidiasis 30.3 CLEC7A IFNG IL10
17 demyelinating disease 30.2 IFNG IL10 TNF
18 viral encephalitis 30.0 IL10 IL6 TNF
19 bacterial meningitis 30.0 IL10 IL6 TNF
20 myocarditis 29.9 HLA-B IL6 TNF
21 leishmaniasis 29.9 IFNG IL10 TNF
22 central nervous system disease 29.9 IFNG IL6 TNF
23 monocytic leukemia 29.8 IFNG IL6 TNF
24 erythema multiforme 29.7 IFNG IL2 TNF
25 cytomegalovirus infection 29.7 IFNG IL10 IL6 KIR3DL1 TNF
26 crohn's disease 29.7 IL10 IL6 TNF
27 rheumatic disease 29.7 HLA-B IFNG IL10 TNF
28 meningitis 29.7 IFNG IL10 IL6 TNF
29 multicentric castleman disease 29.7 IFNG IL10 IL6
30 nervous system disease 29.6 IFNG IL10 IL6 TNF
31 arthritis 29.5 IFNG IL10 IL6 TNF
32 tetanus 29.5 IFNG IL10 IL2
33 toxoplasmosis 29.5 IFNG IL10 IL6 TNF
34 conjunctivitis 29.4 IFNG IL2 IL6
35 sezary's disease 29.4 CTLA4 IFNG IL2 KIR3DL1
36 periodontitis 29.3 IFNG IL10 IL6 TNF
37 interstitial lung disease 29.2 IFNG IL10 IL6 TNF
38 visceral leishmaniasis 29.2 IFNG IL10 IL2 TNF
39 herpes zoster 29.2 HLA-A IFNG IL10 IL2
40 hashimoto thyroiditis 29.2 CTLA4 IFNG IL2
41 ulcerative colitis 29.1 IL10 IL2 IL6 TNF
42 aplastic anemia 29.0 HLA-A HLA-B IFNG IL2 IL6 TNF
43 colitis 28.9 IFNG IL10 IL2 IL6 TNF
44 myasthenia gravis 28.6 CTLA4 IFNG IL10 IL2 TNF
45 multiple sclerosis 28.6 CTLA4 IFNG IL10 IL2 IL6 TNF
46 systemic lupus erythematosus 28.1 CTLA4 IFNG IL10 IL2 IL6 TNF
47 graft-versus-host disease 28.1 ARHGAP45 HLA-A HLA-B HLA-C IFNG IL10
48 autoimmune disease 28.0 CTLA4 HLA-B IFNG IL10 IL2 IL6
49 common variable immunodeficiency 27.7 CTLA4 IFNG IL10 IL2 IL6 TNF
50 rheumatoid arthritis 27.7 CTLA4 HLA-B IFNG IL10 IL2 IL6

Graphical network of the top 20 diseases related to Hematopoietic Stem Cell Transplantation:



Diseases related to Hematopoietic Stem Cell Transplantation
Sources

Symptoms & Phenotypes for Hematopoietic Stem Cell Transplantation

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GenomeRNAi Phenotypes related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

26 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.28 CLEC7A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.28 HLA-B HLA-A CLEC7A HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.28 CLEC7A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.28 HLA-B HLA-A HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.28 HLA-E
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.28 HLA-B HLA-A HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.28 CLEC7A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.28 HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.28 CLEC7A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.28 CLEC7A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.28 CLEC7A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.28 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.28 CLEC7A HLA-C HLA-E
14 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.28 HLA-A HLA-B HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.28 CLEC7A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.28 HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.28 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.28 HLA-E
19 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.28 HLA-B HLA-A HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.28 CLEC7A HLA-E
21 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.28 HLA-B HLA-A HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.28 CLEC7A HLA-C
23 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.28 CLEC7A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.28 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.28 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.28 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.28 HLA-B HLA-A HLA-C HLA-E
28 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.28 HLA-C
29 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.28 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.28 HLA-B HLA-A HLA-C
31 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.28 HLA-B HLA-A HLA-C
32 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.28 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.28 CLEC7A
34 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.28 HLA-C

MGI Mouse Phenotypes related to Hematopoietic Stem Cell Transplantation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CLEC7A CTLA4 IFNG IL10 IL2 IL6
2 respiratory system MP:0005388 9.17 CLEC7A CTLA4 IFNG IL10 IL2 IL6
Sources

Drugs & Therapeutics for Hematopoietic Stem Cell Transplantation

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Drugs for Hematopoietic Stem Cell Transplantation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 595)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
3
Azacitidine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 320-67-2 9444
4
Decitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2353-33-5 451668
5
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
7
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
8
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
9
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
10
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 104987-11-3 445643 439492
11
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 84625-61-6 55283
12
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
13
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
14
Lomustine Approved, Investigational Phase 4,Not Applicable 13010-47-4 3950
15
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 128794-94-5 5281078
16
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24280-93-1 446541
17
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
18
Vidarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 24356-66-9 32326 21704
19
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 171228-49-2 147912
20
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137234-62-9 71616
21
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 152923-56-3, 179045-86-4
22
Foscarnet Approved Phase 4,Phase 3,Phase 2,Not Applicable 63585-09-1, 4428-95-9 3415
23
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 82410-32-0 3454
24
Menthol Approved Phase 4,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
25
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
26
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
27
Deferasirox Approved, Investigational Phase 4,Phase 2 201530-41-8 5493381
28
Iron Approved Phase 4,Phase 2,Phase 3,Not Applicable 7439-89-6 23925
29
Protein C Approved Phase 4
30
Aprepitant Approved, Investigational Phase 4,Not Applicable 170729-80-3 151165 6918365
31
Fosaprepitant Approved Phase 4,Not Applicable 172673-20-0 219090
32
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 44475014
33
Ledipasvir Approved Phase 4 1256388-51-8 67505836
34
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
35
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
36
Tropisetron Approved, Investigational Phase 4 105826-92-4, 89565-68-4 5595
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
39
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable 50-14-6 5280793
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 1406-16-2
41
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 67-97-0 6221 5280795
42
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
43
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4 13422-55-4
44 Semustine Experimental, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 13909-09-6
45
Phosphonoacetic Acid Experimental Phase 4,Phase 3,Phase 2,Not Applicable 4408-78-0 546
46
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
47
Substance P Investigational Phase 4,Not Applicable 33507-63-0 44359816
48 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
50 Echinocandins Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1779)
# Name Status NCT ID Phase Drugs
1 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
2 Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT Unknown status NCT01379391 Phase 4 Recombinant Human Thrombopoietin (rHTPO)
3 Decitabine for Myelodysplastic Syndromes and Acute Myeloid Leukemia Before Allogeneic Hematopoietic Cell Transplantation Unknown status NCT01806116 Phase 4 decitabine
4 Oral Hygiene Regimen in Patients on HCT Unknown status NCT02662374 Phase 4 .02% Chlorohexidine Gluconate;3% Sodium Bicarbonate;Nystatin 10000U/ml;Supersaturated Calcium Phosphate
5 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
6 Post Hematopoietic Stem Cell Transplantation Completed NCT01610297 Phase 4 ICL670
7 Study to Assess the Safety and Efficacy of Tacrolimus (Prograf Capsule/Injection) and Methotrexate (MTX) Combination Therapy for Prevention of Graft Versus Host Disease (GVHD) in Patients Who Received Peripheral Hematopoietic Stem Cell Transplantation Fro Completed NCT02660684 Phase 4 Prograf;Methotrexate;Cyclosporine
8 Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation Completed NCT00336531 Phase 4 itraconazole
9 ATG in Haploidentical HSCT for Acute Graft-versus-host Disease Prophylaxis Completed NCT01883180 Phase 4 ATG
10 Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload Completed NCT01335035 Phase 4 deferasirox
11 Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients Completed NCT00204958 Phase 4 nutritional supplement;glutamine popsicle
12 Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload Completed NCT00654589 Phase 4 Deferasirox
13 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4 albuterol plus tiotropium
14 Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT) Completed NCT00361140 Phase 4 Busulfan;Fludarabine
15 A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow Transplantation Completed NCT00067730 Phase 4 Drotrecogin Alfa (activated)
16 Feasibility of Prophylactic Haldol to Prevent Delirium in Cancer Patients Completed NCT03489551 Phase 4 Haldol
17 Adjuvanted Influenza Vaccine in Stem Cell Transplant Completed NCT02560909 Phase 4
18 A New Dosing Regimen for Posaconazole Prophylaxis in Children Based on Body Surface Area Completed NCT02372357 Phase 4 Posaconazole prophylaxis 120 mg/m² tid
19 A Trial Comparing Efficacy and Safety of Voriconazole Administered With Therapeutic Drug Monitoring vs. Standard Dosing Completed NCT01416025 Phase 4 Prospective TDM Arm
20 Erythropoietin in the Treatment of Anemia After Autologous Hematopoietic Stem Cell Transplantation Recruiting NCT03010579 Phase 4 erythropoietin;iron supplementation
21 Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major Recruiting NCT03171831 Phase 4 Busulfan;Cyclophosphamide;Fludarabine;Mycophenolate mofetil;Tacrolimus;Methotrexate;Thymoglobulin;Basiliximab
22 Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major Recruiting NCT02342145 Phase 4 Basiliximab,;cyclosporine A;Methotrexate;Mycophenolate mofetil
23 Ledipasvir/Sofosbuvir Treatment for Hepatitis C in HCT Recipients. Recruiting NCT03279133 Phase 4 Ledipasvir 90mg/Sofosubvir 400mg
24 CMV-CTL for the Treatment of CMV Infection After HSCT Recruiting NCT03004261 Phase 4 Foscarnet;Ganciclovir
25 PEG-rhG-CSF in Lymphoma Patients After Autologous Hematopoietic Stem Cell Transplantation Recruiting NCT02905942 Phase 4 PEG-rhG-CSF;rhG-CSF
26 Post-transplantation Cyclophosphamide for Haploidentical Transplant From Maternal or Collateral Donors Recruiting NCT02412423 Phase 4 post-transplantation cyclophosphamide
27 Study of Standard and Individualized Treatment Model for Relapse and Refractory Lymphatic System Malignant Tumors Recruiting NCT02929615 Phase 4
28 Early Tapering of Immunosuppressive Agents to Immunomodulation to Improve Survival of AML Patients Recruiting NCT03150134 Phase 4 Cyclosporine;routine reduction of immunosuppressive drugs(cyclosporine)
29 Peg Interferon α-2b for Relapsed Hematological Malignancies After Allo-HSCT Recruiting NCT02634294 Phase 4 Peg interferon alfa-2b
30 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
31 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti－human Thymoglobulin;Placebo
32 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
33 A Pralatrexate Study in Asian Patients With Peripheral T-cell Lymphoma After Prior Therapy Recruiting NCT03150602 Phase 4 Pralatrexate
34 A Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation Active, not recruiting NCT02576327 Phase 4 Tropisetron;Dexamethasone;Aprepitant
35 A Optimal Anti-Thymoglobuline (ATG) Dose Decrease cGVHD But Not Increase Leukemia Relapse for Haplo-HSCT Not yet recruiting NCT03190733 Phase 4 ATG
36 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
37 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
38 Hematopoietic Stem Cell Transplantation for Mucopolysaccharidosis Unknown status NCT01238328 Phase 2, Phase 3 Conditioning regimen;Graft-versus-host disease (GVHD) prophylaxis
39 Hematopoietic Stem Cell Transplantation for Malignant Infantile Osteopetrosis Unknown status NCT01087398 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Thymoglobulin, Fludarabine (Conditioning regimen);Cyclosporin, Methotrexate (GVHD prophylaxis)
40 Palifermin for Patients Receiving Hematopoietic Stem Cell Transplantation Unknown status NCT02313792 Phase 3 Palifermin
41 Hematopoietic Stem Cell Transplantation in Myeloma Unknown status NCT00415987 Phase 2, Phase 3
42 Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Unknown status NCT01800643 Phase 2, Phase 3
43 Allogeneic Transplantation For Severe Osteopetrosis Unknown status NCT00775931 Phase 2, Phase 3 Campath-1H;Cyclophosphamide;Busulfan;Fludarabine monophosphate
44 Lactobacillus Brevis CD2 Preventing Oral Mucositis Unknown status NCT02085694 Phase 2, Phase 3 Lactobacillus brevis CD2
45 Randomized, Prospective, Multicenter Study to Compare Enteral Nutrition to Parenteral Nutrition as Feeding Support in Patients Presenting Malignant Hemopathy Who Underwent an Allogeneic Hematopoietic Stem Cell Transplantation. Unknown status NCT01955772 Phase 3 Enteral nutrition alanyl-glutamin, Dipeptiven
46 The Effect of Folinic Acid Rescue Following MTX GVHD Prophylaxis on Regimen Related Toxicity and Transplantation Outcome Unknown status NCT02506231 Phase 2, Phase 3 Folinic acid;Placebo
47 Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
48 Prospective Study of Patients With Thrombocytopenia Following HSCT Unknown status NCT02487563 Phase 3 decitabine;rhTPO
49 Hemofiltration for Respiratory Failure After Bone Marrow Transplantation Unknown status NCT00120575 Phase 2, Phase 3
50 Interferon Alfa-2b Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma Unknown status NCT00003924 Phase 3

Search NIH Clinical Center for Hematopoietic Stem Cell Transplantation

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hematopoietic Stem Cell Transplantation cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hematopoietic Stem Cell Transplantation:
ATIR
Bone marrow-derived mesenchymal stem cells combined with cord blood for treatment of graft failure
Bone marrow-derived mesenchymal stem cells for treatment of poor graft function
Embryonic/Adult Cultured Cells Related to Hematopoietic Stem Cell Transplantation:
ATIR PMIDs: 17977031 17878399 23206844 20798236 12091325
Bone marrow-derived mesenchymal stem cells
Sources

Genetic Tests for Hematopoietic Stem Cell Transplantation

About this section
Sources

Anatomical Context for Hematopoietic Stem Cell Transplantation

About this section

MalaCards organs/tissues related to Hematopoietic Stem Cell Transplantation:

41
T Cells, Myeloid, Bone, Bone Marrow, B Cells, Kidney, Lung
Sources

Publications for Hematopoietic Stem Cell Transplantation

About this section

Articles related to Hematopoietic Stem Cell Transplantation:

(show top 50) (show all 2047)
# Title Authors Year
1
Outcomes of Children with Hemophagocytic Lymphohistiocytosis Given Allogeneic Hematopoietic Stem Cell Transplantation in Italy. ( 29410181 )
2018
2
Allogeneic hematopoietic stem cell transplantation in Primary Cutaneous T Cell Lymphoma. ( 29442161 )
2018
3
Possible involvement of IL-6-producing tissue-resident macrophages in early-onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation. ( 29384263 )
2018
4
Successful reduced-intensity conditioning hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria with aplastic anemia in two children. ( 29722478 )
2018
5
Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with IL-6 Elevation Caused by Odontogenic Infection. ( 29877260 )
2018
6
Successful treatment of pure red cell aplasia with high-dose dexamethasone after ABO-incompatible allogeneic hematopoietic stem cell transplantation. ( 29079126 )
2018
7
Successful hematopoietic stem cell transplantation for osteopetrosis using reduced intensity conditioning. ( 29469225 )
2018
8
Visual perceptual skills and visual motor integration in children and adolescents after allogeneic hematopoietic stem cell transplantation. ( 29417695 )
2018
9
Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. ( 29741437 )
2018
10
Access to hematopoietic stem cell transplant for patients with sickle cell anemia. ( 29693782 )
2018
11
BK Viremia as a Predictor of Hemorrhagic Cystitis in Adults During the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplantation. ( 29880378 )
2018
12
Autoimmune thyroiditis following HLA-matched sibling hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome. ( 29761856 )
2018
13
The impact of individual comorbidities on non-relapse mortality following allogeneic hematopoietic stem cell transplantation. ( 29950692 )
2018
14
When there is no match, the game is not over: Alternative donor options for hematopoietic stem cell transplantation in sickle cell disease. ( 29958565 )
2018
15
Cardiac output response to exercise in patients before allogenic hematopoietic stem cell transplantation. ( 29974294 )
2018
16
Tenofovir Alafenamide Associated Fatal Lactic Acidosis in an Autologous Hematopoietic Stem Cell Transplant Recipient. ( 29975806 )
2018
17
Renal Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation: InvolvementA ofA Chronic Graft-Versus-Host Disease. ( 29854984 )
2018
18
Patient selection and timing of allogeneic hematopoietic stem cell transplantation for relapsed follicular lymphoma. ( 29927482 )
2018
19
Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism. ( 28860001 )
2018
20
The Clinical and Economic Impact of Cytomegalovirus Infection in Recipients of Hematopoietic Stem Cell Transplantation. ( 29975816 )
2018
21
Total Hip Arthroplasty in Patients With Avascular Necrosis After Hematopoietic Stem Cell Transplantation. ( 29451944 )
2018
22
Salvaged allogeneic hematopoietic stem cell transplantation for pediatric chemotherapy refractory acute leukemia. ( 29423036 )
2018
23
Multiple Spitz nevi after allogeneic hematopoietic stem cell transplantation. ( 29943855 )
2018
24
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
25
CD1d is a novel cell-surface marker for human monocytic myeloid-derived suppressor cells with T cell suppression activity in peripheral blood after allogeneic hematopoietic stem cell transplantation. ( 29108995 )
2018
26
Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. ( 29345206 )
2018
27
Allogeneic hematopoietic stem cell transplantation for relapsed follicular lymphoma: A combined analysis on behalf of the Lymphoma Working Party of the EBMT and the Lymphoma Committee of the CIBMTR. ( 29424927 )
2018
28
Impact of hematopoietic stem cell transplant on VEP and ABR values of the patients with malignant infantile osteopetrosis. ( 29730165 )
2018
29
Efficacy of high-dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation. ( 29417689 )
2018
30
Get Outta Here! Addition of Mobilizing Agents to Conditioning Regimen Improves Donor Engraftment after Allogeneic Hematopoietic Stem Cell Transplantation for Wiskott-Aldrich Syndrome. ( 29753160 )
2018
31
Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant. ( 29388318 )
2018
32
Veno-venous extracorporeal membrane oxygenation bridged living-donor lung transplantation for rapid progressive respiratory failure with pleuroparenchymal fibroelastosis after allogeneic hematopoietic stem cell transplantation. ( 29773298 )
2018
33
Allogeneic hematopoietic stem cell transplantation for children and adolescents with high-risk cytogenetic AML: distinctly poor outcomes of FUS-ERG-positive cases. ( 29959436 )
2018
34
Severe Congenital Neutropenia associated with SRP54 mutation in 22q11.2 Deletion Syndrome: Hematopoietic Stem Cell Transplantation Results in Correction of Neutropenia with Adequate Immune Reconstitution. ( 29956078 )
2018
35
Treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: the role of corticosteroids. ( 29532160 )
2018
36
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
37
18F-3'-deoxy-3'-fluorothymidine (FLT) PET imaging for the prediction of acute graft-versus-host disease in mouse hematopoietic stem cell transplant models. ( 29981461 )
2018
38
Long-term aprepitant for nausea and vomiting associated with gastroparesis in hematopoietic stem cell transplantation. ( 29795419 )
2018
39
Correction: Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. ( 29771974 )
2018
40
High incidence of BK virus-associated hemorrhagic cystitis in children after second or third allogeneic hematopoietic stem cell transplantation. ( 29654658 )
2018
41
Radiological Improvement of Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation in a Patient Treated with Ruxolitinib. ( 29803525 )
2018
42
Allogeneic hematopoietic stem cell transplantation should be in preference to conventional chemotherapy as post-remission treatment for adults with lymphoblastic lymphoma. ( 29712994 )
2018
43
Haploidentical hematopoietic stem cell transplantation for adult patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. ( 28573910 )
2018
44
Lung histopathology of noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation. ( 29953629 )
2018
45
Hemorrhagic cystitis after hematopoietic stem cell transplantation: A challenge for the pediatric urologist. ( 29776868 )
2018
46
Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. ( 29684567 )
2018
47
Hematopoietic Stem Cell Transplantation in Late-Onset Krabbe Disease: No Evidence of Worsening Demyelination and Axonal Loss 4 Years Post-allograft. ( 29479774 )
2018
48
Outcomes of measurable residual disease in pediatric acute myeloid leukemia pre- and post-hematopoietic stem cell transplant: validation of difference from normal flow cytometry with chimerism studies and Wilms tumor 1 gene expression. ( 29933069 )
2018
49
Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation. ( 29706650 )
2018
50
Advantages of non-cryopreserved autologous hematopoietic stem cell transplantation against a cryopreserved strategy. ( 29440738 )
2018
Sources

Variations for Hematopoietic Stem Cell Transplantation

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Expression for Hematopoietic Stem Cell Transplantation

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Search GEO for disease gene expression data for Hematopoietic Stem Cell Transplantation.
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Pathways for Hematopoietic Stem Cell Transplantation

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Pathways related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.87 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C
2
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.46 CTLA4 HLA-A HLA-B HLA-C HLA-E KIR2DL1
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.32 HLA-A HLA-B HLA-C HLA-E IFNG IL10
4
PI3K-Akt signaling pathway 37
Show member pathways
 13 HLA-A HLA-B HLA-C HLA-E IL2 IL6
5
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.97 IFNG IL10 IL2 IL6 TNF
6
Influenza A 37
Show member pathways
 12.75 HLA-A HLA-B HLA-C HLA-E IFNG IL2
7
Immune response IL-23 signaling pathway 22
Show member pathways
 12.62 IFNG IL10 IL2 IL6 TNF
8
NF-kappaB Signaling 4
12.59 CTLA4 IFNG IL10 IL2 TNF
9
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.59 HLA-A HLA-B HLA-C HLA-E IL6 TNF
10
Interferon gamma signaling 66
Show member pathways
 12.56 HLA-A HLA-B HLA-C HLA-E IFNG
11
Th17 cell differentiation 37
Show member pathways
 12.48 IFNG IL10 IL2 IL6 TNF
12
Antigen processing-Cross presentation 66
Show member pathways
 12.46 HLA-A HLA-B HLA-C HLA-E
13
T cell receptor signaling pathway 37
Show member pathways
 12.42 CTLA4 IFNG IL10 IL2 IL6 TNF
14
Regulation of IFNA signaling 66
Show member pathways
 12.4 HLA-A HLA-B HLA-C HLA-E IFNG IL10
15
Endocytosis 37
12.39 HLA-A HLA-B HLA-C HLA-E
16
Folate Metabolism 1
Show member pathways
 12.38 IFNG IL2 IL6 MTHFR TNF
17
HTLV-I infection 37
12.38 HLA-A HLA-B HLA-C HLA-E IL2 IL6
18
Viral carcinogenesis 37
12.31 HLA-A HLA-B HLA-C HLA-E
19
Th1 Differentiation Pathway 65
Show member pathways
 12.3 IFNG IL10 IL2 IL6 TNF
20
Epstein-Barr virus infection 37
12.29 HLA-A HLA-B HLA-C HLA-E IFNG IL10
21
Tuberculosis 37
12.27 CLEC7A IFNG IL10 IL6 TNF
22
C-type lectin receptor signaling pathway 37
Show member pathways
 12.25 CLEC7A IL10 IL2 IL6 TNF
23
Allograft rejection 1 37
Show member pathways
 12.18 CTLA4 HLA-A HLA-B HLA-C HLA-E IFNG
24
Phagosome 37
12.17 CLEC7A HLA-A HLA-B HLA-C HLA-E
25
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.13 HLA-A HLA-B HLA-C HLA-E IFNG IL2
26
Cell adhesion molecules (CAMs) 37
12.12 CTLA4 HLA-A HLA-B HLA-C HLA-E
27
Cellular senescence (KEGG) 37
12.07 HLA-A HLA-B HLA-C HLA-E IL6 KIR2DL1
28
Spinal Cord Injury 1
12.05 IFNG IL2 IL6 TNF
29
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.01 IFNG IL10 IL2 IL6 TNF
30
Interleukin-4 and 13 signaling 66
11.95 IL10 IL6 TNF
31
IL12-mediated signaling events 1
Show member pathways
 11.94 HLA-A IFNG IL2
32
Jak-Stat Signaling Pathway 67
11.94 IFNG IL10 IL2 IL6
33
Amoebiasis 37
11.94 IFNG IL10 IL6 TNF
34
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 66
11.93 HLA-A HLA-B HLA-C HLA-E KIR2DL1 KIR2DL3
35
Rheumatoid arthritis 37
11.91 CTLA4 IFNG IL6 TNF
36
Innate Lymphoid Cell Differentiation Pathways 65
11.85 IFNG IL10 IL2 TNF
37
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.82 CTLA4 IFNG IL2 TNF
38
Glucocorticoid receptor regulatory network 1
11.8 IFNG IL2 IL6
39
Pertussis 37
11.76 IL10 IL6 TNF
40
Dendritic Cells Developmental Lineage Pathway 65
11.74 IFNG IL10 IL2 IL6 TNF
41
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.72 IFNG IL2 IL6 TNF
42
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.69 HLA-A IFNG IL2 TNF
43
Photodynamic therapy-induced AP-1 survival signaling. 1
11.59 IFNG IL2 IL6 TNF
44
Interleukin-10 signaling 66
11.57 IL10 IL6 TNF
45
Malaria 37
11.57 IFNG IL10 IL6 TNF
46
Aryl Hydrocarbon Receptor Pathway 1
11.56 IFNG IL2 TNF
47
Th2 Differentiation Pathway 65
11.53 IFNG IL10 IL2
48
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.52 IFNG IL6 TNF
49
IL-10 Pathway 64
11.4 IL10 IL6 TNF
50
African trypanosomiasis 37
11.37 IFNG IL10 IL6 TNF
Sources

GO Terms for Hematopoietic Stem Cell Transplantation

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Cellular components related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 CTLA4 HLA-A HLA-B KIR2DL1 KIR2DL3 KIR3DL1
2 cell surface GO:0009986 9.83 HLA-A HLA-B HLA-C HLA-E TNF
3 early endosome membrane GO:0031901 9.67 HLA-A HLA-B HLA-C HLA-E
4 recycling endosome membrane GO:0055038 9.62 HLA-A HLA-B HLA-C HLA-E
5 phagocytic vesicle membrane GO:0030670 9.56 HLA-A HLA-B HLA-C HLA-E
6 ER to Golgi transport vesicle membrane GO:0012507 9.46 HLA-A HLA-B HLA-C HLA-E
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-C HLA-E
8 MHC class I protein complex GO:0042612 8.92 HLA-A HLA-B HLA-C HLA-E
9 plasma membrane GO:0005886 10.2 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C

Biological processes related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.97 IFNG IL10 IL2 IL6 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.93 IL10 IL2 IL6 TNF
3 adaptive immune response GO:0002250 9.91 CTLA4 HLA-E IFNG IL2
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.82 IL10 IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.8 HLA-E IL6 TNF
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.8 HLA-A HLA-B HLA-C HLA-E
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IFNG IL2 IL6
8 response to glucocorticoid GO:0051384 9.76 IL10 IL6 TNF
9 type I interferon signaling pathway GO:0060337 9.76 HLA-A HLA-B HLA-C HLA-E
10 humoral immune response GO:0006959 9.75 IFNG IL6 TNF
11 antigen processing and presentation GO:0019882 9.71 HLA-A HLA-B HLA-C HLA-E
12 regulation of immune response GO:0050776 9.7 HLA-A HLA-B HLA-C HLA-E KIR2DL1 KIR2DL3
13 negative regulation of B cell proliferation GO:0030889 9.65 CTLA4 IL10
14 regulation of regulatory T cell differentiation GO:0045589 9.65 CTLA4 IFNG IL2
15 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-B HLA-C HLA-E IFNG
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IFNG TNF
17 negative regulation of growth of symbiont in host GO:0044130 9.63 IL10 TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 TNF
19 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.62 HLA-A HLA-B HLA-C HLA-E
20 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
21 positive regulation of immunoglobulin secretion GO:0051024 9.61 HLA-E IL2 IL6
22 endothelial cell apoptotic process GO:0072577 9.6 IL10 TNF
23 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
24 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IFNG TNF
26 protection from natural killer cell mediated cytotoxicity GO:0042270 9.54 HLA-A HLA-B HLA-E
27 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 IFNG TNF
28 immune response GO:0006955 9.44 CTLA4 HLA-A HLA-B HLA-C HLA-E IFNG
29 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.26 HLA-A HLA-B HLA-C HLA-E
30 immune system process GO:0002376 10 CLEC7A CTLA4 HLA-A HLA-B HLA-C IL2

Molecular functions related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 IFNG IL10 IL2 IL6 TNF
2 beta-2-microglobulin binding GO:0030881 9.26 HLA-A HLA-E
3 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-C HLA-E
4 protein binding GO:0005515 10.03 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C
Sources

Sources for Hematopoietic Stem Cell Transplantation

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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