MCID: HMT018
MIFTS: 58

Hematopoietic Stem Cell Transplantation

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hematopoietic Stem Cell Transplantation

MalaCards integrated aliases for Hematopoietic Stem Cell Transplantation:

Name: Hematopoietic Stem Cell Transplantation 38 59

Characteristics:

Orphanet epidemiological data:

59
hematopoietic stem cell transplantation
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe);

Classifications:



External Ids:

Orphanet 59 ORPHA90053
ICD10 via Orphanet 34 Z94.8

Summaries for Hematopoietic Stem Cell Transplantation

MalaCards based summary : Hematopoietic Stem Cell Transplantation is related to aspergillosis and immunodysregulation, polyendocrinopathy, and enteropathy, x-linked. An important gene associated with Hematopoietic Stem Cell Transplantation is ARHGAP45 (Rho GTPase Activating Protein 45), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Hydroxocobalamin and Iron have been mentioned in the context of this disorder. Affiliated tissues include t cells, myeloid and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem... more...

Related Diseases for Hematopoietic Stem Cell Transplantation

Diseases related to Hematopoietic Stem Cell Transplantation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 760)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 32.5 CLEC7A IFNG IL10 TNF
2 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 32.3 IFNG IL10 IL2
3 chronic active epstein-barr virus infection 32.1 CTLA4 IFNG IL10 IL2
4 chronic graft versus host disease 31.3 IFNG IL10 TNF
5 acute graft versus host disease 30.9 ARHGAP45 IFNG IL10 IL2 TNF
6 bronchiolitis 30.9 IFNG IL10 IL6 TNF
7 bronchiolitis obliterans 30.9 IFNG IL10 IL6 TNF
8 pneumonia 30.9 IL10 IL6 TNF
9 post-transplant lymphoproliferative disease 30.7 IL10 IL6 TNF
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 CTLA4 IFNG IL10
11 hemophagocytic lymphohistiocytosis 30.7 CTLA4 IFNG IL10 TNF
12 cytomegalovirus infection 30.5 HLA-A HLA-B HLA-E IL6 TNF
13 pure red-cell aplasia 30.4 HLA-A HLA-B IL2
14 relapsing-remitting multiple sclerosis 30.4 IFNG IL10 TNF
15 graft-versus-host disease 30.4 ARHGAP45 HLA-A HLA-B HLA-C IFNG IL10
16 aplastic anemia 30.3 HLA-A HLA-B IFNG IL2 IL6 TNF
17 cytomegalovirus retinitis 30.3 HLA-A HLA-B IFNG TNF
18 omenn syndrome 30.3 IFNG IL10 TNF
19 demyelinating disease 30.3 IFNG IL10 TNF
20 toxoplasmosis 30.3 IFNG IL10 IL6 TNF
21 bacterial infectious disease 30.3 IFNG IL10 IL6 TNF
22 candidiasis 30.2 CLEC7A IFNG IL10
23 arthritis 30.1 IFNG IL10 IL6 TNF
24 trichosporonosis 30.1 IFNG TNF
25 viral infectious disease 30.0 IFNG IL10 IL2 IL6 TNF
26 multiple sclerosis 30.0 CTLA4 IFNG IL10 IL2 IL6 TNF
27 monocytic leukemia 30.0 IFNG IL6 TNF
28 mycobacterium tuberculosis 1 29.9 IFNG IL10 TNF
29 rheumatic disease 29.9 HLA-B IFNG IL10 TNF
30 meningitis 29.9 IFNG IL10 IL6 TNF
31 myocarditis 29.9 HLA-B IL6 TNF
32 sezary's disease 29.9 CTLA4 IFNG IL2 KIR3DL1
33 gastroenteritis 29.8 IL10 IL6 TNF
34 bacterial meningitis 29.8 IL10 IL6 TNF
35 autoimmune disease 29.8 CTLA4 HLA-B IFNG IL10 IL2 IL6
36 severe cutaneous adverse reaction 29.8 HLA-A HLA-B HLA-C TNF
37 crohn's colitis 29.8 IFNG IL2 TNF
38 pericarditis 29.8 IFNG IL6 TNF
39 rubella 29.8 HLA-A HLA-B IL10 TNF
40 herpes zoster 29.8 HLA-A HLA-B IFNG IL10 IL2
41 viral encephalitis 29.7 IL10 IL6 TNF
42 central nervous system vasculitis 29.7 IFNG IL6 TNF
43 colitis 29.7 CTLA4 IFNG IL10 IL2 IL6 TNF
44 human herpesvirus 8 29.6 HLA-A HLA-B HLA-C IL6
45 tetanus 29.6 IFNG IL10 IL2
46 appendicitis 29.6 IL10 IL6 TNF
47 diabetes mellitus, insulin-dependent 29.6 CTLA4 HLA-A IFNG IL10 IL6
48 connective tissue disease 29.6 IFNG IL10 IL6 TNF
49 erythema multiforme 29.5 IFNG IL2 TNF
50 systemic lupus erythematosus 29.5 CTLA4 IFNG IL10 IL2 IL6 TNF

Graphical network of the top 20 diseases related to Hematopoietic Stem Cell Transplantation:



Diseases related to Hematopoietic Stem Cell Transplantation

Symptoms & Phenotypes for Hematopoietic Stem Cell Transplantation

GenomeRNAi Phenotypes related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

26 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.28 CLEC7A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.28 HLA-A HLA-B HLA-C CLEC7A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.28 CLEC7A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.28 HLA-A HLA-B HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.28 HLA-E
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.28 HLA-A HLA-B HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.28 CLEC7A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.28 HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.28 CLEC7A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.28 CLEC7A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.28 CLEC7A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.28 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.28 HLA-C HLA-E CLEC7A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.28 HLA-A HLA-B HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.28 CLEC7A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.28 HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.28 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.28 HLA-E
19 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.28 HLA-A HLA-B HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.28 HLA-E CLEC7A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.28 HLA-A HLA-B HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.28 HLA-C CLEC7A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.28 CLEC7A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.28 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.28 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.28 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.28 HLA-A HLA-B HLA-C HLA-E
28 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.28 HLA-C
29 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.28 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.28 HLA-A HLA-B HLA-C
31 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.28 HLA-A HLA-B HLA-C
32 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.28 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.28 CLEC7A
34 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.28 HLA-C

MGI Mouse Phenotypes related to Hematopoietic Stem Cell Transplantation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 CLEC7A CTLA4 IFNG IL10 IL2 IL6
2 liver/biliary system MP:0005370 9.5 CTLA4 IFNG IL10 IL2 IL6 MTHFR
3 respiratory system MP:0005388 9.17 CLEC7A CTLA4 IFNG IL10 IL2 IL6

Drugs & Therapeutics for Hematopoietic Stem Cell Transplantation

Drugs for Hematopoietic Stem Cell Transplantation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 606)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 44475014
2
Iron Approved Phase 4,Phase 2,Phase 3,Not Applicable 7439-89-6 23925
3
Methylcobalamin Approved, Experimental, Investigational Phase 4 13422-55-4
4
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 6006 143
5
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
7
Aprepitant Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 170729-80-3 6918365 151165
8
Fosaprepitant Approved Phase 4,Phase 1,Phase 2,Not Applicable 172673-20-0 219090
9
Tropisetron Approved, Investigational Phase 4 89565-68-4, 105826-92-4 5595
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
12
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
13
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24280-93-1 446541
14
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 152923-56-3, 179045-86-4
15
Decitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2353-33-5 451668
16
Azacitidine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 320-67-2 9444
17
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
18
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
19
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
20
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
21
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 104987-11-3 445643 439492
22
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 84625-61-6 55283
23
Lomustine Approved, Investigational Phase 4,Not Applicable 13010-47-4 3950
24
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
25
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
26
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
27
Vidarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 24356-66-9 32326 21704
28
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 171228-49-2 147912
29
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137234-62-9 71616
30
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 82410-32-0 3454
31
Foscarnet Approved Phase 4,Phase 3,Phase 2,Not Applicable 63585-09-1, 4428-95-9 3415
32
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
33
Deferasirox Approved, Investigational Phase 4,Phase 2 201530-41-8 5493381
34
Protein C Approved Phase 4
35
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
36
Haloperidol Approved Phase 4 52-86-8 3559
37
Crizotinib Approved Phase 4,Phase 3 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
38
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
39
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 1406-16-2
41
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 67-97-0 5280795 6221
42
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable 50-14-6 5280793
43
Cobalamin Experimental Phase 4 13408-78-1 6438156
44
Substance P Investigational Phase 4,Phase 1,Phase 2,Not Applicable 33507-63-0 44359816
45 Semustine Experimental, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 13909-09-6
46
Phosphonoacetic Acid Experimental Phase 4,Phase 3,Phase 2,Not Applicable 4408-78-0 546
47
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
48 Epoetin alfa Phase 4,Phase 2,Phase 3 113427-24-0
49 Vitamin B 12 Phase 4
50 Hematinics Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 1909)
# Name Status NCT ID Phase Drugs
1 Erythropoietin in the Treatment of Anemia After Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT03010579 Phase 4 erythropoietin;iron supplementation
2 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
3 Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT Unknown status NCT01379391 Phase 4 Recombinant Human Thrombopoietin (rHTPO)
4 A Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT02576327 Phase 4 Tropisetron;Dexamethasone;Aprepitant
5 Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major Unknown status NCT02342145 Phase 4 Basiliximab,;cyclosporine A;Methotrexate;Mycophenolate mofetil
6 PEG-rhG-CSF in Lymphoma Patients After Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT02905942 Phase 4 PEG-rhG-CSF;rhG-CSF
7 Decitabine for Myelodysplastic Syndromes and Acute Myeloid Leukemia Before Allogeneic Hematopoietic Cell Transplantation Unknown status NCT01806116 Phase 4 decitabine
8 Oral Hygiene Regimen in Patients on HCT Unknown status NCT02662374 Phase 4 .02% Chlorohexidine Gluconate;3% Sodium Bicarbonate;Nystatin 10000U/ml;Supersaturated Calcium Phosphate
9 Study of Standard and Individualized Treatment Model for Relapse and Refractory Lymphatic System Malignant Tumors Unknown status NCT02929615 Phase 4
10 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
11 Post Hematopoietic Stem Cell Transplantation Completed NCT01610297 Phase 4 ICL670
12 Study to Assess the Safety and Efficacy of Tacrolimus (Prograf Capsule/Injection) and Methotrexate (MTX) Combination Therapy for Prevention of Graft Versus Host Disease (GVHD) in Patients Who Received Peripheral Hematopoietic Stem Cell Transplantation From a Sibling Donor Completed NCT02660684 Phase 4 Prograf;Methotrexate;Cyclosporine
13 Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation Completed NCT00336531 Phase 4 itraconazole
14 ATG in Haploidentical HSCT for Acute Graft-versus-host Disease Prophylaxis Completed NCT01883180 Phase 4 ATG
15 Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload Completed NCT01335035 Phase 4 deferasirox
16 Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients Completed NCT00204958 Phase 4 nutritional supplement;glutamine popsicle
17 Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload Completed NCT00654589 Phase 4 Deferasirox
18 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4 albuterol plus tiotropium
19 Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT) Completed NCT00361140 Phase 4 Busulfan;Fludarabine
20 Post-transplantation Cyclophosphamide for Haploidentical Transplant From Maternal or Collateral Donors Completed NCT02412423 Phase 4 post-transplantation cyclophosphamide
21 A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow Transplantation Completed NCT00067730 Phase 4 Drotrecogin Alfa (activated)
22 Feasibility of Prophylactic Haldol to Prevent Delirium in Cancer Patients Completed NCT03489551 Phase 4 Haldol
23 Adjuvanted Influenza Vaccine in Stem Cell Transplant Completed NCT02560909 Phase 4
24 A New Dosing Regimen for Posaconazole Prophylaxis in Children Based on Body Surface Area Completed NCT02372357 Phase 4 Posaconazole prophylaxis 120 mg/m² tid
25 A Trial Comparing Efficacy and Safety of Voriconazole Administered With Therapeutic Drug Monitoring vs. Standard Dosing Completed NCT01416025 Phase 4 Prospective TDM Arm
26 Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major Recruiting NCT03171831 Phase 4 Busulfan;Cyclophosphamide;Fludarabine;Mycophenolate mofetil;Tacrolimus;Methotrexate;Thymoglobulin;Basiliximab
27 CMV-CTL for the Treatment of CMV Infection After HSCT Recruiting NCT03004261 Phase 4 Foscarnet;Ganciclovir
28 PTCy-ATG vs ATG in Haploidentical HSCT for Acute Graft-versus-host Disease Prophylaxis Recruiting NCT03689465 Phase 4 ATG;CTX;Mycophenolate Mofetil
29 Crizotinib Combined With Etoposide Capsule Followed by Auto-HSCT for Relapsed and Refractory ALK+ ALCL Recruiting NCT03707847 Phase 4 Crizotinib;Etoposide Capsule
30 Early Tapering of Immunosuppressive Agents to Immunomodulation to Improve Survival of AML Patients Recruiting NCT03150134 Phase 4 Cyclosporine;routine reduction of immunosuppressive drugs(cyclosporine)
31 Gardasil 9 Vaccine in Preventing HPV Infection in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant Recruiting NCT03023631 Phase 4
32 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
33 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
34 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
35 A Pralatrexate Study in Asian Patients With Peripheral T-cell Lymphoma After Prior Therapy Recruiting NCT03150602 Phase 4 Pralatrexate
36 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Enrolling by invitation NCT03176849 Phase 4
37 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients Not yet recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
38 A Optimal Anti-Thymoglobuline (ATG) Dose Decrease cGVHD But Not Increase Leukemia Relapse for Haplo-HSCT Not yet recruiting NCT03190733 Phase 4 ATG
39 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
40 Ledipasvir/Sofosbuvir Treatment for Hepatitis C in HCT Recipients. Withdrawn NCT03279133 Phase 4 Ledipasvir 90mg/Sofosubvir 400mg
41 Hematopoietic Stem Cell Transplantation for Mucopolysaccharidosis Unknown status NCT01238328 Phase 2, Phase 3 Conditioning regimen;Graft-versus-host disease (GVHD) prophylaxis
42 Hematopoietic Stem Cell Transplantation for Malignant Infantile Osteopetrosis Unknown status NCT01087398 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Thymoglobulin, Fludarabine (Conditioning regimen);Cyclosporin, Methotrexate (GVHD prophylaxis)
43 Palifermin for Patients Receiving Hematopoietic Stem Cell Transplantation Unknown status NCT02313792 Phase 3 Palifermin
44 TCR Alpha/Beta Depletion for HSCT From Haploidentical and Unrelated Donors in the Treatment of PID Unknown status NCT02327351 Phase 2, Phase 3
45 Hematopoietic Stem Cell Transplantation in Myeloma Unknown status NCT00415987 Phase 2, Phase 3
46 Sorafenib for Prophylaxis of Leukemia Relapse in Allo-HSCT Recipients With FLT3-ITD Positive AML Unknown status NCT02474290 Phase 2, Phase 3 Sorafenib
47 Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Unknown status NCT01800643 Phase 2, Phase 3
48 MRD-directed Donor Lymphocyte Infusion for Reduce of Relapse After Allo-HSCT Unknown status NCT02673008 Phase 2, Phase 3
49 Allogeneic Transplantation For Severe Osteopetrosis Unknown status NCT00775931 Phase 2, Phase 3 Campath-1H;Cyclophosphamide;Busulfan;Fludarabine monophosphate
50 Lactobacillus Brevis CD2 Preventing Oral Mucositis Unknown status NCT02085694 Phase 2, Phase 3 Lactobacillus brevis CD2

Search NIH Clinical Center for Hematopoietic Stem Cell Transplantation

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Genetic Tests for Hematopoietic Stem Cell Transplantation

Anatomical Context for Hematopoietic Stem Cell Transplantation

MalaCards organs/tissues related to Hematopoietic Stem Cell Transplantation:

41
T Cells, Myeloid, Bone, Bone Marrow, B Cells, Lung, Nk Cells

Publications for Hematopoietic Stem Cell Transplantation

Articles related to Hematopoietic Stem Cell Transplantation:

(show top 50) (show all 3032)
# Title Authors Year
1
Plasma-based protein biomarkers can predict the risk of acute graft-versus-host disease and non-relapse mortality in patients undergoing allogeneic hematopoietic stem cell transplantation. ( 30344086 )
2019
2
Unrelated allogeneic hematopoietic stem cell transplantation in a patient with Revesz syndrome, a severe variant of dyskeratosis congenita. ( 30259646 )
2019
3
Differences in pulmonary and extra-pulmonary characteristics in severely versus non-severely fatigued recipients of allogeneic hematopoietic stem cell transplantation: a cross-sectional, comparative study. ( 30261831 )
2019
4
Evaluation of cardiopulmonary exercise testing, heart function, and quality of life in children after allogenic hematopoietic stem cell transplantation. ( 30318730 )
2019
5
Prognostic significance of normalized FDG-PET parameters in patients with multiple myeloma undergoing induction chemotherapy and autologous hematopoietic stem cell transplantation: a retrospective single-center evaluation. ( 30054697 )
2019
6
Outcomes of Children with Hemophagocytic Lymphohistiocytosis Given Allogeneic Hematopoietic Stem Cell Transplantation in Italy. ( 29410181 )
2018
7
Allogeneic hematopoietic stem cell transplantation in Primary Cutaneous T Cell Lymphoma. ( 29442161 )
2018
8
Possible involvement of IL-6-producing tissue-resident macrophages in early-onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation. ( 29384263 )
2018
9
Successful reduced-intensity conditioning hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria with aplastic anemia in two children. ( 29722478 )
2018
10
Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with IL-6 Elevation Caused by Odontogenic Infection. ( 29877260 )
2018
11
Successful treatment of pure red cell aplasia with high-dose dexamethasone after ABO-incompatible allogeneic hematopoietic stem cell transplantation. ( 29079126 )
2018
12
Successful hematopoietic stem cell transplantation for osteopetrosis using reduced intensity conditioning. ( 29469225 )
2018
13
Visual perceptual skills and visual motor integration in children and adolescents after allogeneic hematopoietic stem cell transplantation. ( 29417695 )
2018
14
Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. ( 29741437 )
2018
15
BK Viremia as a Predictor of Hemorrhagic Cystitis in Adults During the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplantation. ( 29880378 )
2018
16
Autoimmune thyroiditis following HLA-matched sibling hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome. ( 29761856 )
2018
17
The impact of individual comorbidities on non-relapse mortality following allogeneic hematopoietic stem cell transplantation. ( 29950692 )
2018
18
When there is no match, the game is not over: Alternative donor options for hematopoietic stem cell transplantation in sickle cell disease. ( 29958565 )
2018
19
Cardiac output response to exercise in patients before allogenic hematopoietic stem cell transplantation. ( 29974294 )
2018
20
Renal Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation: InvolvementA ofA Chronic Graft-Versus-Host Disease. ( 29854984 )
2018
21
Patient selection and timing of allogeneic hematopoietic stem cell transplantation for relapsed follicular lymphoma. ( 29927482 )
2018
22
Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism. ( 28860001 )
2018
23
The Clinical and Economic Impact of Cytomegalovirus Infection in Recipients of Hematopoietic Stem Cell Transplantation. ( 29975816 )
2018
24
Total Hip Arthroplasty in Patients With Avascular Necrosis After Hematopoietic Stem Cell Transplantation. ( 29451944 )
2018
25
Salvaged allogeneic hematopoietic stem cell transplantation for pediatric chemotherapy refractory acute leukemia. ( 29423036 )
2018
26
Multiple Spitz nevi after allogeneic hematopoietic stem cell transplantation. ( 29943855 )
2018
27
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
28
CD1d is a novel cell-surface marker for human monocytic myeloid-derived suppressor cells with T cell suppression activity in peripheral blood after allogeneic hematopoietic stem cell transplantation. ( 29108995 )
2018
29
Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. ( 29345206 )
2018
30
Allogeneic hematopoietic stem cell transplantation for relapsed follicular lymphoma: A combined analysis on behalf of the Lymphoma Working Party of the EBMT and the Lymphoma Committee of the CIBMTR. ( 29424927 )
2018
31
Efficacy of high-dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation. ( 29417689 )
2018
32
Get Outta Here! Addition of Mobilizing Agents to Conditioning Regimen Improves Donor Engraftment after Allogeneic Hematopoietic Stem Cell Transplantation for Wiskott-Aldrich Syndrome. ( 29753160 )
2018
33
Veno-venous extracorporeal membrane oxygenation bridged living-donor lung transplantation for rapid progressive respiratory failure with pleuroparenchymal fibroelastosis after allogeneic hematopoietic stem cell transplantation. ( 29773298 )
2018
34
Allogeneic hematopoietic stem cell transplantation for children and adolescents with high-risk cytogenetic AML: distinctly poor outcomes of FUS-ERG-positive cases. ( 29959436 )
2018
35
Severe Congenital Neutropenia associated with SRP54 mutation in 22q11.2 Deletion Syndrome: Hematopoietic Stem Cell Transplantation Results in Correction of Neutropenia with Adequate Immune Reconstitution. ( 29956078 )
2018
36
Treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: the role of corticosteroids. ( 29532160 )
2018
37
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
38
Long-term aprepitant for nausea and vomiting associated with gastroparesis in hematopoietic stem cell transplantation. ( 29795419 )
2018
39
High incidence of BK virus-associated hemorrhagic cystitis in children after second or third allogeneic hematopoietic stem cell transplantation. ( 29654658 )
2018
40
Radiological Improvement of Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation in a Patient Treated with Ruxolitinib. ( 29803525 )
2018
41
Allogeneic hematopoietic stem cell transplantation should be in preference to conventional chemotherapy as post-remission treatment for adults with lymphoblastic lymphoma. ( 29712994 )
2018
42
Haploidentical hematopoietic stem cell transplantation for adult patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. ( 28573910 )
2018
43
Lung histopathology of noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation. ( 29953629 )
2018
44
Hemorrhagic cystitis after hematopoietic stem cell transplantation: A challenge for the pediatric urologist. ( 29776868 )
2018
45
Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. ( 29684567 )
2018
46
Hematopoietic Stem Cell Transplantation in Late-Onset Krabbe Disease: No Evidence of Worsening Demyelination and Axonal Loss 4 Years Post-allograft. ( 29479774 )
2018
47
Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation. ( 29706650 )
2018
48
Advantages of non-cryopreserved autologous hematopoietic stem cell transplantation against a cryopreserved strategy. ( 29440738 )
2018
49
Natural Killer Cells Regulate Th17 Cells After Autologous Hematopoietic Stem Cell Transplantation for Relapsing Remitting Multiple Sclerosis. ( 29867923 )
2018
50
Nephrogenic diabetes insipidus in initial stage of acute lymphoblastic leukemia and relapse after haploidentical hematopoietic stem-cell transplantation: A case report. ( 29901649 )
2018

Variations for Hematopoietic Stem Cell Transplantation

Expression for Hematopoietic Stem Cell Transplantation

Search GEO for disease gene expression data for Hematopoietic Stem Cell Transplantation.

Pathways for Hematopoietic Stem Cell Transplantation

Pathways related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C
2
Show member pathways
13.46 CTLA4 HLA-A HLA-B HLA-C HLA-E KIR2DL1
3
Show member pathways
13.34 HLA-A HLA-B HLA-C HLA-E IFNG IL10
4
Show member pathways
13.06 HLA-A HLA-B HLA-C HLA-E IL6 TNF
5
Show member pathways
13.02 HLA-A HLA-B HLA-C HLA-E IL2 IL6
6
Show member pathways
12.97 IFNG IL10 IL2 IL6 TNF
7
Show member pathways
12.75 HLA-A HLA-B HLA-C HLA-E IFNG IL2
8
Show member pathways
12.63 IFNG IL10 IL2 IL6 TNF
9
Show member pathways
12.62 IFNG IL10 IL2 IL6 TNF
10 12.59 CTLA4 IFNG IL10 IL2 TNF
11
Show member pathways
12.56 HLA-A HLA-B HLA-C HLA-E IFNG
12
Show member pathways
12.46 HLA-A HLA-B HLA-C HLA-E
13
Show member pathways
12.43 CTLA4 IFNG IL10 IL2 IL6 TNF
14 12.4 HLA-A HLA-B HLA-C HLA-E
15
Show member pathways
12.38 IFNG IL10 IL2 IL6
16
Show member pathways
12.38 IFNG IL2 IL6 MTHFR TNF
17 12.38 HLA-A HLA-B HLA-C HLA-E IL2 IL6
18 12.31 HLA-A HLA-B HLA-C HLA-E
19 12.3 HLA-A HLA-B HLA-C HLA-E IL6 TNF
20 12.28 CLEC7A IFNG IL10 IL6 TNF
21
Show member pathways
12.25 CLEC7A IL10 IL2 IL6 TNF
22 12.18 CLEC7A HLA-A HLA-B HLA-C HLA-E
23
Show member pathways
12.18 CTLA4 HLA-A HLA-B HLA-C HLA-E IFNG
24 12.14 CTLA4 HLA-A HLA-B HLA-C HLA-E
25
Show member pathways
12.13 HLA-A HLA-B HLA-C HLA-E IFNG IL2
26
Show member pathways
12.08 IFNG IL10 IL2 IL6 TNF
27 12.07 HLA-A HLA-B HLA-C HLA-E IL6 KIR2DL1
28
Show member pathways
12.04 IFNG IL10 IL2 IL6
29 12.04 IFNG IL2 IL6 TNF
30 12.02 IFNG IL10 IL2 IL6 TNF
31
Show member pathways
12.02 HLA-A HLA-B HLA-C HLA-E IFNG IL10
32
Show member pathways
12 IFNG IL6 TNF
33 11.95 IL10 IL6 TNF
34
Show member pathways
11.95 HLA-A IFNG IL2
35 11.94 IFNG IL10 IL6 TNF
36 11.93 HLA-A HLA-B HLA-C HLA-E KIR2DL1 KIR2DL3
37 11.91 IFNG IL10 IL2 IL6
38 11.91 CTLA4 IFNG IL6 TNF
39 11.85 IFNG IL10 IL2 TNF
40
Show member pathways
11.82 CTLA4 IFNG IL2 TNF
41 11.8 IFNG IL2 IL6
42 11.77 IL10 IL6 TNF
43 11.76 IFNG IL10 IL2 IL6 TNF
44 11.73 IFNG IL10 IL2 IL6 TNF
45
Show member pathways
11.72 IFNG IL2 IL6 TNF
46
Show member pathways
11.7 HLA-A IFNG IL2 TNF
47 11.61 IFNG IL2 IL6 TNF
48 11.58 IFNG IL10 IL6 TNF
49 11.57 IL10 IL6 TNF
50 11.56 IFNG IL2 TNF

GO Terms for Hematopoietic Stem Cell Transplantation

Cellular components related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 CTLA4 HLA-A HLA-B KIR2DL1 KIR2DL3 KIR3DL1
2 cell surface GO:0009986 9.85 HLA-A HLA-B HLA-C HLA-E TNF
3 early endosome membrane GO:0031901 9.67 HLA-A HLA-B HLA-C HLA-E
4 recycling endosome membrane GO:0055038 9.62 HLA-A HLA-B HLA-C HLA-E
5 phagocytic vesicle membrane GO:0030670 9.56 HLA-A HLA-B HLA-C HLA-E
6 ER to Golgi transport vesicle membrane GO:0012507 9.46 HLA-A HLA-B HLA-C HLA-E
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-C HLA-E
8 MHC class I protein complex GO:0042612 8.92 HLA-A HLA-B HLA-C HLA-E
9 plasma membrane GO:0005886 10.17 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C

Biological processes related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.97 IFNG IL10 IL2 IL6 TNF
2 adaptive immune response GO:0002250 9.93 CTLA4 HLA-E IFNG IL2
3 cytokine-mediated signaling pathway GO:0019221 9.93 IL10 IL2 IL6 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 IL10 IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.81 HLA-E IL6 TNF
6 type I interferon signaling pathway GO:0060337 9.81 HLA-A HLA-B HLA-C HLA-E
7 regulation of immune response GO:0050776 9.8 HLA-A HLA-B HLA-C HLA-E KIR2DL1 KIR2DL3
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 IFNG IL2 IL6
9 response to glucocorticoid GO:0051384 9.78 IL10 IL6 TNF
10 antigen processing and presentation GO:0019882 9.78 HLA-A HLA-B HLA-C HLA-E
11 humoral immune response GO:0006959 9.77 IFNG IL6 TNF
12 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.73 HLA-A HLA-B HLA-C HLA-E
13 interferon-gamma-mediated signaling pathway GO:0060333 9.72 HLA-A HLA-B HLA-C HLA-E IFNG
14 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 HLA-A HLA-B HLA-C HLA-E
15 regulation of regulatory T cell differentiation GO:0045589 9.7 CTLA4 IFNG IL2
16 positive regulation of immunoglobulin secretion GO:0051024 9.67 HLA-E IL2 IL6
17 positive regulation of T cell mediated cytotoxicity GO:0001916 9.67 HLA-A HLA-B HLA-C HLA-E
18 positive regulation of glial cell proliferation GO:0060252 9.66 IL6 TNF
19 negative regulation of B cell proliferation GO:0030889 9.66 CTLA4 IL10
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.65 IL10 TNF
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 IL10 TNF
23 protection from natural killer cell mediated cytotoxicity GO:0042270 9.63 HLA-A HLA-B HLA-E
24 negative regulation of lipid storage GO:0010888 9.62 IL6 TNF
25 endothelial cell apoptotic process GO:0072577 9.62 IL10 TNF
26 negative regulation of cytokine secretion involved in immune response GO:0002740 9.59 IL10 TNF
27 positive regulation of neuroinflammatory response GO:0150078 9.58 IL6 TNF
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IFNG TNF
29 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
30 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
31 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.46 HLA-A HLA-B HLA-C HLA-E
32 immune response GO:0006955 9.44 CTLA4 HLA-A HLA-B HLA-C HLA-E IFNG
33 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.26 HLA-A HLA-B HLA-C HLA-E
34 immune system process GO:0002376 10.02 CLEC7A CTLA4 HLA-A HLA-B HLA-C IL2

Molecular functions related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 IFNG IL10 IL2 IL6 TNF
2 beta-2-microglobulin binding GO:0030881 9.26 HLA-A HLA-E
3 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-C HLA-E
4 protein binding GO:0005515 10.03 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C

Sources for Hematopoietic Stem Cell Transplantation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....