MCID: HMC012
MIFTS: 26

Hemicrania Continua

Categories: Eye diseases, Neuronal diseases, Rare diseases, Smell/Taste diseases

Aliases & Classifications for Hemicrania Continua

MalaCards integrated aliases for Hemicrania Continua:

Name: Hemicrania Continua 54 55 60 74

Characteristics:

Orphanet epidemiological data:

60
hemicrania continua
Inheritance: Not applicable;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 G44.0
Orphanet 60 ORPHA443070
UMLS 74 C2349425

Summaries for Hemicrania Continua

NINDS : 55 Hemicrania continua is a chronic and persistent form of headache marked by continuous pain that varies in severity, always occurs on the same side of the face and head, and is superimposed with additional debilitating symptoms.  on the continuous but fluctuating pain are occasional attacks of more severe pain.  A small percentage of individuals with hemicrania continua have bilateral pain, or pain on both sides of the head.  A headache is considered hemicrania continua if the person has had a one-sided daily or continuous headache of moderate intensity with occasional short, piercing head pain for more than 3 months without shifting sides or pain-free periods.  The headache must also be completely responsive to treatment with the non-steroidal anti-inflammatory drug drug indomethacin.  It must have at least one of the following symptoms:  eye redness and/or tearing, nasal congestion and/or runny nose, ptosis (drooping eyelid) and miosis (contracture of the iris).  Occasionally, individuals will also have forehead sweating and migraine symptoms, such as throbbing pain, nausea and/or vomiting, or sensitivity to light and sound.  The disorder has two forms: chronic, with daily headaches, and remitting, in which headaches may occur for a period as long as 6 months and are followed by a pain-free period of weeks to months until the pain returns. Most patients experience attacks of increased pain three to five times per 24-hour cycle. This disorder is more common in women than in men. Physical exertion and alcohol use may increase the severity of headache pain in some patients. The cause of this disorder is unknown.

MalaCards based summary : Hemicrania Continua is related to paroxysmal hemicrania and headache, and has symptoms including headache The drugs Capsaicin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and lung.

NIH Rare Diseases : 54 Hemicrania continua (HC) is a type of primary headache disorder, which means the headache is not caused by another medical condition. Symptoms of HC include constant mild to moderate pain on one side of the head (unilateral) with periods of more intense, severe, migraine-like pain (exacerbations). These severe pain periods can last from 20 minutes to days. The frequency of exacerbations also varies greatly. The headache stays on the same side of the head and usually without pain free periods. HC is more common in women and most often starts in adulthood, but may begin anywhere from 5 to 67 years of age. Diagnosis of hemicrania continua (HC) is made by ruling out other possible causes of the pain and by clinical symptoms. During the periods of severe pain, at least one of the following symptoms must be present on same side of the body as the headache: watering or red eyes (conjunctival injection), congested or runny nose, or drooping eyelid. In addition, the headache pain must respond to treatment with indomethacin. The cause of HC is unknown. Other treatments for those who cannot tolerate long term indomethacin therapy are being studied.

Wikipedia : 77 Hemicrania continua (HC) is a persistent unilateral headache that responds to indomethacin. It is... more...

Related Diseases for Hemicrania Continua

Diseases related to Hemicrania Continua via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 paroxysmal hemicrania 11.8
2 headache 10.9
3 cluster headache 10.5
4 carotid artery dissection 10.4
5 trigeminal neuralgia 10.3
6 lung cancer 10.3
7 leprosy 3 10.3
8 migraine with aura 10.3
9 hansen's disease 10.3
10 thrombophilia due to thrombin defect 10.1
11 osteoid osteoma 10.1
12 nasopharyngeal carcinoma 10.1
13 major depressive disorder 10.1
14 brain injury 10.1
15 traumatic brain injury 10.1
16 familial hemiplegic migraine 10.1
17 thrombosis 10.1
18 migraine without aura 10.1
19 patent foramen ovale 10.1
20 herpes zoster 10.1
21 scotoma 10.1
22 hemiplegic migraine 10.1
23 herpes zoster ophthalmicus 10.1
24 idiopathic hypertrophic pachymeningitis 10.1
25 new daily-persistent headache 10.1
26 sunct headache 10.1
27 depression 10.1
28 igg4-related pachymeningitis 10.1

Graphical network of the top 20 diseases related to Hemicrania Continua:



Diseases related to Hemicrania Continua

Symptoms & Phenotypes for Hemicrania Continua

UMLS symptoms related to Hemicrania Continua:


headache

Drugs & Therapeutics for Hemicrania Continua

Drugs for Hemicrania Continua (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 1 404-86-4 1548943
2 Pharmaceutical Solutions Phase 1
3 Antipruritics Phase 1
4 Dermatologic Agents Phase 1
5 Peripheral Nervous System Agents Phase 1
6
Triamcinolone Approved, Vet_approved 124-94-7 31307
7 Triamcinolone hexacetonide
8 triamcinolone acetonide
9 Triamcinolone diacetate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pain Biomarker Study Active, not recruiting NCT03511846 Phase 1 Oral capsaicin;Topical capsaicin;Intranasal capsaicin;Low Flow Oxygen;High Flow Oxygen
2 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
3 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323

Search NIH Clinical Center for Hemicrania Continua

Genetic Tests for Hemicrania Continua

Anatomical Context for Hemicrania Continua

MalaCards organs/tissues related to Hemicrania Continua:

42
Eye, Brain, Lung, Hypothalamus

Publications for Hemicrania Continua

Articles related to Hemicrania Continua:

(show top 50) (show all 196)
# Title Authors Year
1
A case of remitting hemicrania continua with seasonal variation and clustering: a diagnostic confusion with cluster headache. ( 31110069 )
2019
2
The Exacerbation of Hemicrania Continua Mimics Trigeminal Neuralgia. ( 30333409 )
2019
3
Topiramate as an Indomethacin-Sparing Agent in Hemicrania Continua: A Report of 2 Cases. ( 30802948 )
2019
4
Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology? ( 28056533 )
2018
5
Herpes zoster ophthalmicus evolving into headache characterised as hemicrania continua. ( 29574434 )
2018
6
Idiopathic hypertrophic pachymeningitis mimicking hemicrania continua: An unusual clinical case. ( 28474987 )
2018
7
Hemicrania continua: Case series presenting in an orofacial pain clinic. ( 29562746 )
2018
8
Hemicrania Continua Associated with Classic Scintillating Scotoma. ( 29681827 )
2018
9
Hemicrania Continua. ( 29720815 )
2018
10
Hemicrania Continua: a Clinical Perspective on Diagnosis and Management. ( 30328517 )
2018
11
Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. ( 28730562 )
2017
12
Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy. ( 27933631 )
2017
13
Hemicrania continua-like headache secondary to nasopharyngeal carcinoma: A case report. ( 27288353 )
2017
14
Two Cases of Hemicrania Continua-Trigeminal Neuralgia Syndrome: Expanding the Spectrum of Trigeminal Autonomic Cephalalgia-Tic (TAC-TIC) Syndrome. ( 27753068 )
2017
15
Hemicrania Continua: Beneficial Effect of Non-Invasive Vagus Nerve Stimulation in a Patient With a Contraindication for Indomethacin. ( 27861830 )
2017
16
Treatment of intractable hemicrania continua by occipital nerve stimulation. ( 28255029 )
2017
17
Hemicrania continua: clinical review, diagnosis and management. ( 28721092 )
2017
18
Hemicrania continua may respond to repetitive sphenopalatine ganglion block: A case report. ( 26926875 )
2016
19
Postoperative hemicrania continua-like headache - a case series. ( 25968100 )
2015
20
Hemicrania continua with visual aura successfully treated with a combination of indomethacin and topiramate. ( 25501961 )
2015
21
How effective is melatonin as a preventive treatment for hemicrania continua? A clinic-based study. ( 25711410 )
2015
22
Treatment of hemicrania continua with radiofrequency ablation and long-term follow-up. ( 25720768 )
2015
23
Raeder paratrigeminal neuralgia evolving to hemicrania continua. ( 25756337 )
2015
24
OnabotulinumtoxinA for hemicrania continua: open label experience in 9 patients. ( 25902798 )
2015
25
Hemicrania continua with contralateral cranial autonomic features: a case report. ( 25902939 )
2015
26
Hemicrania Continua. ( 26084243 )
2015
27
Hemicrania continua and unilateral headaches: are they still together in the IHS classification? ( 28132353 )
2015
28
Melatonin responsive hemicrania continua in which indomethacin was associated with contralateral headache. ( 24261314 )
2014
29
Hemicrania continua. ( 24452694 )
2014
30
Hemicrania continua: towards a new classification? ( 24524413 )
2014
31
Hemicrania continua--building on experience and clinical science. ( 24524422 )
2014
32
Indomethacin as a cause of headache in hemicrania continua. ( 24554621 )
2014
33
Hemicrania continua--major shortcomings in the new classification or rigid thinking is death to progress. ( 25167842 )
2014
34
A case report of hemicrania continua-like headache due to ipsilateral inflammatory orbital pseudotumor. ( 25168202 )
2014
35
A case report: indomethacin resistance hemicrania continua or a new entity? ( 25205413 )
2014
36
Hemicrania continua: major shortcomings in the new classification. ( 25216994 )
2014
37
Cerebral venous thrombosis masquerading as hemicrania continua. ( 25387634 )
2014
38
Erratum to: Hemicrania continua- building on experience and clinical science. ( 26088036 )
2014
39
[Successful treatment of hemicrania continua with a combination of low-dose indomethacin and pregabalin: a case report]. ( 25342018 )
2014
40
Continuing on . . . Hemicrania continua. ( 23155192 )
2013
41
Indomethacin-responsive TACs (paroxysmal hemicrania, hemicrania continua, and LASH): further proof of a distinct spectrum of headache disorders. ( 23278259 )
2013
42
Hemicrania continua responsive to botulinum toxin type a: a case report. ( 23534367 )
2013
43
Diagnostic and therapeutic errors in trigeminal autonomic cephalalgias and hemicrania continua: a systematic review. ( 23565739 )
2013
44
Hemicrania continua: functional imaging and clinical features with diagnostic implications. ( 23573807 )
2013
45
Hemicrania continua. Unquestionably a trigeminal autonomic cephalalgia. ( 23573839 )
2013
46
Hemicrania continua should not be classified as a trigeminal autonomic cephalalgia. ( 23573908 )
2013
47
Hemicrania Continua: Functional Imaging and Clinical Features With Diagnostic Implications. ( 23573985 )
2013
48
Indomethacin-induced de novo headache in hemicrania continua--fighting fire with fire? ( 23709499 )
2013
49
Primary continuous unilateral headaches: a nosologic model for hemicrania continua. ( 22407660 )
2012
50
Peripheral nerve blocks: a therapeutic alternative for hemicrania continua. ( 22436371 )
2012

Variations for Hemicrania Continua

Expression for Hemicrania Continua

Search GEO for disease gene expression data for Hemicrania Continua.

Pathways for Hemicrania Continua

GO Terms for Hemicrania Continua

Sources for Hemicrania Continua

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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