MCID: HMC012
MIFTS: 28

Hemicrania Continua

Categories: Eye diseases, Neuronal diseases, Rare diseases, Smell/Taste diseases

Aliases & Classifications for Hemicrania Continua

MalaCards integrated aliases for Hemicrania Continua:

Name: Hemicrania Continua 52 53 58 71

Characteristics:

Orphanet epidemiological data:

58
hemicrania continua
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G44.0
Orphanet 58 ORPHA443070
UMLS 71 C2349425

Summaries for Hemicrania Continua

NINDS : 53 Hemicrania continua is a chronic and persistent form of headache marked by continuous pain that varies in severity, always occurs on the same side of the face and head, and is superimposed with additional debilitating symptoms.  on the continuous but fluctuating pain are occasional attacks of more severe pain.  A small percentage of individuals with hemicrania continua have bilateral pain, or pain on both sides of the head.  A headache is considered hemicrania continua if the person has had a one-sided daily or continuous headache of moderate intensity with occasional short, piercing head pain for more than 3 months without shifting sides or pain-free periods.  The headache must also be completely responsive to treatment with the non-steroidal anti-inflammatory drug drug indomethacin.  It must have at least one of the following symptoms:  eye redness and/or tearing, nasal congestion and/or runny nose, ptosis (drooping eyelid) and miosis (contracture of the iris).  Occasionally, individuals will also have forehead sweating and migraine symptoms, such as throbbing pain, nausea and/or vomiting, or sensitivity to light and sound.  The disorder has two forms: chronic, with daily headaches, and remitting, in which headaches may occur for a period as long as 6 months and are followed by a pain-free period of weeks to months until the pain returns. Most patients experience attacks of increased pain three to five times per 24-hour cycle. This disorder is more common in women than in men. Physical exertion and alcohol use may increase the severity of headache pain in some patients. The cause of this disorder is unknown.

MalaCards based summary : Hemicrania Continua is related to headache and paroxysmal hemicrania, and has symptoms including headache The drugs Ethanol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and lung.

NIH Rare Diseases : 52 Hemicrania continua (HC) is a type of primary headache disorder, which means the headache is not caused by another medical condition. Symptoms of HC include constant mild to moderate pain on one side of the head (unilateral) with periods of more intense, severe, migraine -like pain (exacerbations). These severe pain periods can last from 20 minutes to days. The frequency of exacerbations also varies greatly. The headache stays on the same side of the head and usually without pain free periods. HC is more common in women and most often starts in adulthood, but may begin anywhere from 5 to 67 years of age. Diagnosis of hemicrania continua (HC) is made by ruling out other possible causes of the pain and by clinical symptoms. During the periods of severe pain, at least one of the following symptoms must be present on same side of the body as the headache: watering or red eyes (conjunctival injection), congested or runny nose , or drooping eyelid . In addition, the headache pain must respond to treatment with indomethacin . The cause of HC is unknown. Other treatments for those who cannot tolerate long term indomethacin therapy are being studied.

Wikipedia : 74 Hemicrania continua (HC) is a persistent unilateral headache that responds to indomethacin. It is... more...

Related Diseases for Hemicrania Continua

Diseases related to Hemicrania Continua via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 headache 11.2
2 paroxysmal hemicrania 10.9
3 cluster headache 10.9
4 migraine with or without aura 1 10.8
5 ptosis 10.5
6 trigeminal autonomic cephalalgia 10.5
7 rare headache 10.5
8 migraine without aura 10.4
9 sunct headache 10.4
10 anisocoria 10.4
11 trigeminal neuralgia 10.4
12 migraine with aura 10.4
13 carotid artery dissection 10.4
14 47,xyy 10.4
15 leprosy 3 10.3
16 familial hemiplegic migraine 10.3
17 hansen's disease 10.3
18 hemiplegic migraine 10.3
19 new daily-persistent headache 10.3
20 fibromuscular dysplasia 10.1
21 thrombophilia due to thrombin defect 10.1
22 lung cancer 10.1
23 osteoid osteoma 10.1
24 kearns-sayre syndrome 10.1
25 meningioma, radiation-induced 10.1
26 nasopharyngeal carcinoma 10.1
27 meningioma, familial 10.1
28 major depressive disorder 10.1
29 small cell carcinoma 10.1
30 thrombosis 10.1
31 borderline leprosy 10.1
32 gastric ulcer 10.1
33 spinal meningioma 10.1
34 aseptic meningitis 10.1
35 ocular hyperemia 10.1
36 tolosa-hunt syndrome 10.1
37 patent foramen ovale 10.1
38 multiple cranial nerve palsy 10.1
39 mental depression 10.1
40 mononeuritis multiplex 10.1
41 cranial nerve palsy 10.1
42 secretory meningioma 10.1
43 lymphoplasmacyte-rich meningioma 10.1
44 peripheral nervous system disease 10.1
45 herpes zoster 10.1
46 neuropathy 10.1
47 scotoma 10.1
48 cough headache 10.1
49 herpes zoster ophthalmicus 10.1
50 hypnic headache 10.1

Graphical network of the top 20 diseases related to Hemicrania Continua:



Diseases related to Hemicrania Continua

Symptoms & Phenotypes for Hemicrania Continua

UMLS symptoms related to Hemicrania Continua:


headache

Drugs & Therapeutics for Hemicrania Continua

Drugs for Hemicrania Continua (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Gastrointestinal Agents Phase 4
10 Anesthetics, Local Phase 4
11 Antiemetics Phase 4
12 Anti-Arrhythmia Agents Phase 4
13 Anesthetics Phase 4
14 Methylprednisolone Acetate Phase 4
15 Sodium Channel Blockers Phase 4
16 Hormone Antagonists Phase 4
17 Neuroprotective Agents Phase 4
18 Protective Agents Phase 4
19 Central Nervous System Depressants Phase 4
20 Autonomic Agents Phase 4
21 Anti-Inflammatory Agents Phase 4
22 Antineoplastic Agents, Hormonal Phase 4
23 Diuretics, Potassium Sparing Phase 4
24 glucocorticoids Phase 4
25 Hormones Phase 4
26
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
27 Hypnotics and Sedatives Phase 2
28 Anesthetics, General Phase 2
29 Anesthetics, Intravenous Phase 2
30 Analgesics Phase 2
31
Triamcinolone Approved, Vet_approved 124-94-7 31307
32 Triamcinolone diacetate
33 Triamcinolone hexacetonide
34 triamcinolone acetonide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase IV Single Blind Placebo-controlled Cross Over Study to Investigate the Efficacy of Greater Occipital Nerve Block With Local Anesthetic and Steroid in Patients With Chronic Migraine Active, not recruiting NCT04017741 Phase 4 Combined Depo-Medrone and Lidocaine;Sodium Chloride 0.9% Inj
2 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol
3 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
4 The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal Neuralgia Recruiting NCT02910323

Search NIH Clinical Center for Hemicrania Continua

Genetic Tests for Hemicrania Continua

Anatomical Context for Hemicrania Continua

MalaCards organs/tissues related to Hemicrania Continua:

40
Eye, Brain, Lung, Testes, Pituitary, Hypothalamus, Pineal

Publications for Hemicrania Continua

Articles related to Hemicrania Continua:

(show top 50) (show all 364)
# Title Authors PMID Year
1
Hemicrania Continua. 61 52
26084243 2015
2
Hemicrania Continua Subsequent to Vertebral Artery Dissection: A Case Report. 61
31611169 2019
3
Trigeminal Autonomic Cephalalgias. 61
31563236 2019
4
Do paroxysmal hemicrania and hemicrania continua represent different headaches? A retrospective study. 61
31256266 2019
5
Diagnostic Testing for Migraine and Other Primary Headaches. 61
31563228 2019
6
Multiple cranial nerve blocks for the transitional treatment of chronic headaches. 61
31084198 2019
7
Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. 61
31434691 2019
8
Carotid Cavernous Fistula Mimicking Hemicrania Continua: A Case Report. 61
31166017 2019
9
Trigeminal autonomic cephalalgias presenting in a multidisciplinary tertiary orofacial pain clinic. 61
31185885 2019
10
A case of remitting hemicrania continua with seasonal variation and clustering: a diagnostic confusion with cluster headache. 61
31110069 2019
11
Topiramate as an Indomethacin-Sparing Agent in Hemicrania Continua: A Report of 2 Cases. 61
30802948 2019
12
Chronic persistent Horner's syndrome in trigeminal autonomic cephalalgia subtypes and alleviation with treatment: two case reports. 61
30867062 2019
13
The Exacerbation of Hemicrania Continua Mimics Trigeminal Neuralgia. 61
30333409 2019
14
Nonmigraine Headache and Facial Pain. 61
30704679 2019
15
The Treatment of Trigeminal Autonomic Cephalalgias: An Overview. 61
30703174 2019
16
Hemicrania continua: Case series presenting in an orofacial pain clinic. 61
29562746 2018
17
Hemicrania Continua: a Clinical Perspective on Diagnosis and Management. 61
30328517 2018
18
Cluster Headache and Other Trigeminal Autonomic Cephalalgias. 61
30074553 2018
19
The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications. 61
28942483 2018
20
Predictors of response to occipital nerve stimulation in refractory chronic headache. 61
28901169 2018
21
Non-invasive vagus nerve stimulation for the management of refractory primary chronic headaches: A real-world experience. 61
28899205 2018
22
Hemicrania Continua. 61
29720815 2018
23
Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias. 61
29516437 2018
24
Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management. 61
29720817 2018
25
Functional Neuroimaging in Trigeminal Autonomic Cephalalgias. 61
29720819 2018
26
Idiopathic hypertrophic pachymeningitis mimicking hemicrania continua: An unusual clinical case. 61
28474987 2018
27
Classification of Trigeminal Autonomic Cephalalgia: What has Changed in International Classification of Headache Disorders-3 Beta? 61
29720818 2018
28
Herpes zoster ophthalmicus evolving into headache characterised as hemicrania continua. 61
29574434 2018
29
Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology? 61
28056533 2018
30
Hemicrania Continua Associated with Classic Scintillating Scotoma. 61
29681827 2018
31
Orofacial pain and headaches associated with exfoliation glaucoma. 61
28501097 2017
32
Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. 61
28730562 2017
33
Tics in TACs: A Step into an Avalanche? Systematic Literature Review and Conclusions. 61
28542727 2017
34
Primary Headache Disorders Part I- Migraine and the Trigeminal Autonomic Cephalalgias. 61
28886860 2017
35
Hemicrania continua-like headache secondary to nasopharyngeal carcinoma: A case report. 61
27288353 2017
36
Treatment of intractable hemicrania continua by occipital nerve stimulation. 61
28255029 2017
37
LASH: A Review of the Current Literature. 61
28681219 2017
38
Headache in military service members with a history of mild traumatic brain injury: A cohort study of diagnosis and classification. 61
27206963 2017
39
Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy. 61
27933631 2017
40
Two Cases of Hemicrania Continua-Trigeminal Neuralgia Syndrome: Expanding the Spectrum of Trigeminal Autonomic Cephalalgia-Tic (TAC-TIC) Syndrome. 61
27753068 2017
41
Cluster headache and other TACs: Pathophysiology and neurostimulation options. 61
28128461 2017
42
Hemicrania Continua: Beneficial Effect of Non-Invasive Vagus Nerve Stimulation in a Patient With a Contraindication for Indomethacin. 61
27861830 2017
43
Cracked tooth syndrome mimicking trigeminal autonomic cephalalgia: A report of four cases. 61
28168240 2017
44
Hemicrania continua: clinical review, diagnosis and management. 61
28721092 2017
45
The Role of Melatonin in the Treatment of Primary Headache Disorders. 61
27316772 2016
46
A Cross-Sectional Clinic-Based Study in Patients With Side-Locked Unilateral Headache and Facial Pain. 61
27256162 2016
47
Alcohol-induced headaches: Evidence for a central mechanism? 61
27114660 2016
48
Hemicrania continua may respond to repetitive sphenopalatine ganglion block: A case report. 61
26926875 2016
49
Trigeminal autonomic cephalalgias. 61
24888770 2016
50
Update of Inpatient Treatment for Refractory Chronic Daily Headache. 61
26707496 2016

Variations for Hemicrania Continua

Expression for Hemicrania Continua

Search GEO for disease gene expression data for Hemicrania Continua.

Pathways for Hemicrania Continua

GO Terms for Hemicrania Continua

Sources for Hemicrania Continua

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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