MCID: HMC012
MIFTS: 29

Hemicrania Continua

Categories: Eye diseases, Neuronal diseases, Rare diseases, Smell/Taste diseases

Aliases & Classifications for Hemicrania Continua

MalaCards integrated aliases for Hemicrania Continua:

Name: Hemicrania Continua 53 54 59 72

Characteristics:

Orphanet epidemiological data:

59
hemicrania continua
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 34 G44.0
Orphanet 59 ORPHA443070
UMLS 72 C2349425

Summaries for Hemicrania Continua

NINDS : 54 Hemicrania continua is a chronic and persistent form of headache marked by continuous pain that varies in severity, always occurs on the same side of the face and head, and is superimposed with additional debilitating symptoms.  on the continuous but fluctuating pain are occasional attacks of more severe pain.  A small percentage of individuals with hemicrania continua have bilateral pain, or pain on both sides of the head.  A headache is considered hemicrania continua if the person has had a one-sided daily or continuous headache of moderate intensity with occasional short, piercing head pain for more than 3 months without shifting sides or pain-free periods.  The headache must also be completely responsive to treatment with the non-steroidal anti-inflammatory drug drug indomethacin.  It must have at least one of the following symptoms:  eye redness and/or tearing, nasal congestion and/or runny nose, ptosis (drooping eyelid) and miosis (contracture of the iris).  Occasionally, individuals will also have forehead sweating and migraine symptoms, such as throbbing pain, nausea and/or vomiting, or sensitivity to light and sound.  The disorder has two forms: chronic, with daily headaches, and remitting, in which headaches may occur for a period as long as 6 months and are followed by a pain-free period of weeks to months until the pain returns. Most patients experience attacks of increased pain three to five times per 24-hour cycle. This disorder is more common in women than in men. Physical exertion and alcohol use may increase the severity of headache pain in some patients. The cause of this disorder is unknown.

MalaCards based summary : Hemicrania Continua is related to paroxysmal hemicrania and headache, and has symptoms including headache The drugs Lidocaine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and lung.

NIH Rare Diseases : 53 Hemicrania continua (HC) is a type of primary headache disorder, which means the headache is not caused by another medical condition. Symptoms of HC include constant mild to moderate pain on one side of the head (unilateral) with periods of more intense, severe, migraine-like pain (exacerbations). These severe pain periods can last from 20 minutes to days. The frequency of exacerbations also varies greatly. The headache stays on the same side of the head and usually without pain free periods. HC is more common in women and most often starts in adulthood, but may begin anywhere from 5 to 67 years of age. Diagnosis of hemicrania continua (HC) is made by ruling out other possible causes of the pain and by clinical symptoms. During the periods of severe pain, at least one of the following symptoms must be present on same side of the body as the headache: watering or red eyes (conjunctival injection), congested or runny nose, or drooping eyelid. In addition, the headache pain must respond to treatment with indomethacin. The cause of HC is unknown. Other treatments for those who cannot tolerate long term indomethacin therapy are being studied.

Wikipedia : 75 Hemicrania continua (HC) is a persistent unilateral headache that responds to indomethacin. It is... more...

Related Diseases for Hemicrania Continua

Diseases related to Hemicrania Continua via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 paroxysmal hemicrania 11.9
2 headache 11.2
3 cluster headache 10.9
4 migraine with or without aura 1 10.8
5 ptosis 10.5
6 trigeminal autonomic cephalalgia 10.5
7 rare headache 10.5
8 migraine without aura 10.4
9 sunct headache 10.4
10 anisocoria 10.4
11 trigeminal neuralgia 10.4
12 migraine with aura 10.4
13 carotid artery dissection 10.4
14 47,xyy 10.4
15 leprosy 3 10.3
16 familial hemiplegic migraine 10.3
17 hansen's disease 10.3
18 hemiplegic migraine 10.3
19 new daily-persistent headache 10.3
20 fibromuscular dysplasia 10.1
21 thrombophilia due to thrombin defect 10.1
22 lung cancer 10.1
23 osteoid osteoma 10.1
24 kearns-sayre syndrome 10.1
25 meningioma, radiation-induced 10.1
26 nasopharyngeal carcinoma 10.1
27 meningioma, familial 10.1
28 major depressive disorder 10.1
29 small cell carcinoma 10.1
30 thrombosis 10.1
31 borderline leprosy 10.1
32 gastric ulcer 10.1
33 spinal meningioma 10.1
34 aseptic meningitis 10.1
35 tolosa-hunt syndrome 10.1
36 patent foramen ovale 10.1
37 multiple cranial nerve palsy 10.1
38 mental depression 10.1
39 mononeuritis multiplex 10.1
40 cranial nerve palsy 10.1
41 secretory meningioma 10.1
42 lymphoplasmacyte-rich meningioma 10.1
43 peripheral nervous system disease 10.1
44 herpes zoster 10.1
45 neuropathy 10.1
46 scotoma 10.1
47 cough headache 10.1
48 herpes zoster ophthalmicus 10.1
49 hypnic headache 10.1
50 idiopathic hypertrophic pachymeningitis 10.1

Graphical network of the top 20 diseases related to Hemicrania Continua:



Diseases related to Hemicrania Continua

Symptoms & Phenotypes for Hemicrania Continua

UMLS symptoms related to Hemicrania Continua:


headache

Drugs & Therapeutics for Hemicrania Continua

Drugs for Hemicrania Continua (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Ethanol Approved Phase 4 64-17-5 702
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Anesthetics, Local Phase 4
9 Gastrointestinal Agents Phase 4
10 Sodium Channel Blockers Phase 4
11 Antiemetics Phase 4
12 Neuroprotective Agents Phase 4
13 Diuretics, Potassium Sparing Phase 4
14 Hormones Phase 4
15 Peripheral Nervous System Agents Phase 4
16 glucocorticoids Phase 4
17 Methylprednisolone Acetate Phase 4
18 Anti-Inflammatory Agents Phase 4
19 Protective Agents Phase 4
20 Central Nervous System Depressants Phase 4
21 Antineoplastic Agents, Hormonal Phase 4
22 Anesthetics Phase 4
23 Hormone Antagonists Phase 4
24 Anti-Arrhythmia Agents Phase 4
25 Autonomic Agents Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
27 Prednisolone acetate Phase 4
28
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
29 Analgesics Phase 2
30 Hypnotics and Sedatives Phase 2
31 Anesthetics, General Phase 2
32 Anesthetics, Intravenous Phase 2
33
Triamcinolone Approved, Vet_approved 124-94-7 31307
34 triamcinolone acetonide
35 Triamcinolone diacetate
36 Triamcinolone hexacetonide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase IV Single Blind Placebo-controlled Cross Over Study to Investigate the Efficacy of Greater Occipital Nerve Block With Local Anesthetic and Steroid in Patients With Chronic Migraine Recruiting NCT04017741 Phase 4 Combined Depo-Medrone and Lidocaine;Sodium Chloride 0.9% Inj
2 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol
3 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
4 The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal Neuralgia Recruiting NCT02910323

Search NIH Clinical Center for Hemicrania Continua

Genetic Tests for Hemicrania Continua

Anatomical Context for Hemicrania Continua

MalaCards organs/tissues related to Hemicrania Continua:

41
Eye, Brain, Lung, Testes, Pituitary, Pineal, Hypothalamus

Publications for Hemicrania Continua

Articles related to Hemicrania Continua:

(show top 50) (show all 361)
# Title Authors PMID Year
1
Hemicrania Continua. 38 6
26084243 2015
2
Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. 38
31434691 2019
3
Trigeminal autonomic cephalalgias presenting in a multidisciplinary tertiary orofacial pain clinic. 38
31185885 2019
4
Carotid Cavernous Fistula Mimicking Hemicrania Continua: A Case Report. 38
31166017 2019
5
Do paroxysmal hemicrania and hemicrania continua represent different headaches? A retrospective study. 38
31256266 2019
6
A case of remitting hemicrania continua with seasonal variation and clustering: a diagnostic confusion with cluster headache. 38
31110069 2019
7
Multiple cranial nerve blocks for the transitional treatment of chronic headaches. 38
31084198 2019
8
Nonmigraine Headache and Facial Pain. 38
30704679 2019
9
The Exacerbation of Hemicrania Continua Mimics Trigeminal Neuralgia. 38
30333409 2019
10
Chronic persistent Horner's syndrome in trigeminal autonomic cephalalgia subtypes and alleviation with treatment: two case reports. 38
30867062 2019
11
Topiramate as an Indomethacin-Sparing Agent in Hemicrania Continua: A Report of 2 Cases. 38
30802948 2019
12
The Treatment of Trigeminal Autonomic Cephalalgias: An Overview. 38
30703174 2019
13
Hemicrania continua: Case series presenting in an orofacial pain clinic. 38
29562746 2018
14
Hemicrania Continua: a Clinical Perspective on Diagnosis and Management. 38
30328517 2018
15
Cluster Headache and Other Trigeminal Autonomic Cephalalgias. 38
30074553 2018
16
The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications. 38
28942483 2018
17
Predictors of response to occipital nerve stimulation in refractory chronic headache. 38
28901169 2018
18
Non-invasive vagus nerve stimulation for the management of refractory primary chronic headaches: A real-world experience. 38
28899205 2018
19
Hemicrania Continua. 38
29720815 2018
20
Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias. 38
29516437 2018
21
Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management. 38
29720817 2018
22
Functional Neuroimaging in Trigeminal Autonomic Cephalalgias. 38
29720819 2018
23
Classification of Trigeminal Autonomic Cephalalgia: What has Changed in International Classification of Headache Disorders-3 Beta? 38
29720818 2018
24
Idiopathic hypertrophic pachymeningitis mimicking hemicrania continua: An unusual clinical case. 38
28474987 2018
25
Herpes zoster ophthalmicus evolving into headache characterised as hemicrania continua. 38
29574434 2018
26
Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology? 38
28056533 2018
27
Hemicrania Continua Associated with Classic Scintillating Scotoma. 38
29681827 2018
28
Orofacial pain and headaches associated with exfoliation glaucoma. 38
28501097 2017
29
Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. 38
28730562 2017
30
Tics in TACs: A Step into an Avalanche? Systematic Literature Review and Conclusions. 38
28542727 2017
31
Primary Headache Disorders Part I- Migraine and the Trigeminal Autonomic Cephalalgias. 38
28886860 2017
32
Hemicrania continua-like headache secondary to nasopharyngeal carcinoma: A case report. 38
27288353 2017
33
Treatment of intractable hemicrania continua by occipital nerve stimulation. 38
28255029 2017
34
LASH: A Review of the Current Literature. 38
28681219 2017
35
Headache in military service members with a history of mild traumatic brain injury: A cohort study of diagnosis and classification. 38
27206963 2017
36
Two Cases of Hemicrania Continua-Trigeminal Neuralgia Syndrome: Expanding the Spectrum of Trigeminal Autonomic Cephalalgia-Tic (TAC-TIC) Syndrome. 38
27753068 2017
37
Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy. 38
27933631 2017
38
Cluster headache and other TACs: Pathophysiology and neurostimulation options. 38
28128461 2017
39
Hemicrania Continua: Beneficial Effect of Non-Invasive Vagus Nerve Stimulation in a Patient With a Contraindication for Indomethacin. 38
27861830 2017
40
Cracked tooth syndrome mimicking trigeminal autonomic cephalalgia: A report of four cases. 38
28168240 2017
41
Hemicrania continua: clinical review, diagnosis and management. 38
28721092 2017
42
The Role of Melatonin in the Treatment of Primary Headache Disorders. 38
27316772 2016
43
A Cross-Sectional Clinic-Based Study in Patients With Side-Locked Unilateral Headache and Facial Pain. 38
27256162 2016
44
Alcohol-induced headaches: Evidence for a central mechanism? 38
27114660 2016
45
Hemicrania continua may respond to repetitive sphenopalatine ganglion block: A case report. 38
26926875 2016
46
Update of Inpatient Treatment for Refractory Chronic Daily Headache. 38
26707496 2016
47
Trigeminal autonomic cephalalgias. 38
24888770 2016
48
Hemicrania continua and unilateral headaches: are they still together in the IHS classification? 38
28132353 2015
49
Treatment of hemicrania continua with radiofrequency ablation and long-term follow-up. 38
25720768 2015
50
Trigeminal Autonomic Cephalalgias. 38
26252590 2015

Variations for Hemicrania Continua

Expression for Hemicrania Continua

Search GEO for disease gene expression data for Hemicrania Continua.

Pathways for Hemicrania Continua

GO Terms for Hemicrania Continua

Sources for Hemicrania Continua

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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