MCID: HMD003
MIFTS: 30

Hemidystonia

Categories: Neuronal diseases

Aliases & Classifications for Hemidystonia

MalaCards integrated aliases for Hemidystonia:

Name: Hemidystonia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050846
UMLS 73 C1960561

Summaries for Hemidystonia

Disease Ontology : 12 A multifocal dystonia that involves the arm and leg on the same side of the body.

MalaCards based summary : Hemidystonia is related to blepharospasm and dystonia. An important gene associated with Hemidystonia is CAMP (Cathelicidin Antimicrobial Peptide). Affiliated tissues include brain, globus pallidus and parietal lobe, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Hemidystonia

Diseases related to Hemidystonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 blepharospasm 29.7 CAMP GCH1 THAP1 TOR1A
2 dystonia 28.4 ATP1A3 GCH1 PNKD SGCE TAF1 THAP1
3 hemidystonia-hemiatrophy syndrome 12.0
4 spasmodic dysphonia 10.7 THAP1 TOR1A
5 dystonia 24 10.5 THAP1 TOR1A
6 split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive 10.5 KRIT1 SGCE
7 multifocal dystonia 10.5 ATP1A3 CAMP TOR1A
8 anal spasm 10.5 CAMP KANTR
9 spasmodic dystonia 10.5 CAMP THAP1 TOR1A
10 paraphimosis 10.4 CAMP KANTR
11 anismus 10.4 CAMP KANTR
12 adie pupil 10.3 KANTR TOR1A
13 early-onset generalized dystonia 10.3 GCH1 THAP1 TOR1A
14 sternum cancer 10.1 SMUG1 VIM
15 oromandibular dystonia 10.1 CAMP GCH1 THAP1 TOR1A
16 segmental dystonia 10.1 CAMP GCH1 THAP1 TOR1A
17 brain injury 10.1
18 traumatic brain injury 10.1
19 cervical dystonia 10.1 CAMP GCH1 THAP1 TOR1A
20 thiamine metabolism dysfunction syndrome 2 10.0 GCH1 TOR1A
21 extratemporal epilepsy 9.9 SMUG1 TOR1A
22 focal hand dystonia 9.9 CAMP THAP1 TOR1A VIM
23 glossopharyngeal neuralgia 9.9 KANTR VIM
24 laryngeal tuberculosis 9.9 KANTR SMUG1
25 dystonia 3, torsion, x-linked 9.9 ATP1A3 GCH1 PNKD TAF1 THAP1
26 senile ectropion 9.9 KANTR TWIST1
27 oculomotor nerve paralysis 9.9 CAMP KANTR SMUG1
28 focal dystonia 9.9 CAMP SGCE TAF1 THAP1 TOR1A
29 third cranial nerve disease 9.9 CAMP KANTR SMUG1
30 migraine with or without aura 1 9.9 ATP1A3 KANTR PNKD
31 creutzfeldt-jakob disease 9.8
32 multiple sclerosis 9.8
33 neurofibromatosis, type i 9.8
34 neurofibromatosis, type iv, of riccardi 9.8
35 moyamoya disease 1 9.8
36 diabetes mellitus 9.8
37 vertebral artery occlusion 9.8
38 neuronal ceroid lipofuscinosis 9.8
39 cerebritis 9.8
40 neuronitis 9.8
41 herpes zoster 9.8
42 herpes zoster ophthalmicus 9.8
43 head injury 9.8
44 hypotonia 9.8
45 hemiparkinsonism-hemiatrophy syndrome 9.8
46 plexopathy 9.7 CAMP SMUG1
47 gliosarcoma 9.6 GCH1 TWIST1 VIM
48 oculogyric crisis 9.6 ATP1A3 GCH1 JAG1 KANTR
49 postencephalitic parkinson disease 9.5 KANTR SNCA
50 dystonia 12 9.5 ATP1A3 CAMP GCH1 SGCE THAP1 TOR1A

Graphical network of the top 20 diseases related to Hemidystonia:



Diseases related to Hemidystonia

Symptoms & Phenotypes for Hemidystonia

MGI Mouse Phenotypes related to Hemidystonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ATP1A3 JAG1 PNKD SGCE SNCA THAP1
2 mortality/aging MP:0010768 9.93 CAMP GCH1 JAG1 KRIT1 PRKD1 SMUG1
3 cardiovascular system MP:0005385 9.92 GCH1 JAG1 KRIT1 PRKD1 SGCE SNCA
4 cellular MP:0005384 9.91 CAMP JAG1 SGCE SMUG1 SNCA THAP1
5 muscle MP:0005369 9.56 ATP1A3 JAG1 KRIT1 PRKD1 SGCE TOR1A
6 nervous system MP:0003631 9.36 ATP1A3 GCH1 JAG1 KRIT1 PNKD SGCE

Drugs & Therapeutics for Hemidystonia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia Recruiting NCT02982304 Phase 1
2 Humanitarian Device Exemption Approved for marketing NCT00580658
3 Studying Childhood-Onset Hemidystonia Completed NCT01432899
4 Functional MRI and DTI in the Preoperative Assessment of Dystonia Recruiting NCT02877836 Not Applicable

Search NIH Clinical Center for Hemidystonia

Genetic Tests for Hemidystonia

Anatomical Context for Hemidystonia

MalaCards organs/tissues related to Hemidystonia:

41
Brain, Globus Pallidus, Parietal Lobe, Eye

Publications for Hemidystonia

Articles related to Hemidystonia:

(show all 42)
# Title Authors Year
1
Progressive delayed hemidystonia following clinically mild traumatic brain injury. ( 29288226 )
2017
2
Unilateral thalamic and pallidal deep brain stimulation for idiopathic hemidystonia: results of individual and combined stimulations. Case report. ( 28669294 )
2017
3
Neurocognitive outcomes in children with unilateral basal ganglia arterial ischemic stroke and secondary hemidystonia. ( 28701080 )
2017
4
Multimodal Imaging in a Patient with Hemidystonia Responsive to GPi Deep Brain Stimulation. ( 28744382 )
2017
5
Hemidystonia in a Child With Neurofibromatosis Type 1. ( 27898639 )
2016
6
GPi deep brain stimulation for palliation of hemidystonia and hemibody jerking in a patient with suspected adult onset neuronal ceroid lipofuscinosis. ( 26944153 )
2016
7
Hemidystonia - hemiatrophy syndrome in Domenico Morone's Madonna with child. ( 26736116 )
2016
8
Recurrent episodes of isolated hemidystonia in a young adult: Dissection-associated stenosis in the middle cerebral artery. ( 27374977 )
2016
9
Fluctuating off-period hemidystonia with Pisa syndrome in advanced Parkinson's disease. ( 27423577 )
2016
10
Globus pallidus internus deep brain stimulation for traumatic hemidystonia following penetrating head injury. ( 27184900 )
2016
11
Comment on: Hemidystonia caused by frontal cortical infarction. ( 26607166 )
2016
12
(Pseudo)hemidystonia associated with anti-glutamic acid decarboxylase antibodies - a case report. ( 25846894 )
2015
13
A prospective, randomized, blinded assessment of multitarget thalamic and pallidal deep brain stimulation in a case of hemidystonia. ( 26241157 )
2015
14
Prochlorperazine-Induced Hemidystonia Mimicking Acute Stroke. ( 26265971 )
2015
15
Anesthesia for deep brain stimulation in traumatic brain injury-induced hemidystonia. ( 26185655 )
2015
16
Author's Reply: Hemidystonia caused by frontal cortical infarction. ( 26538401 )
2015
17
Hemidystonia caused by frontal cortical infarction. ( 25119274 )
2014
18
Hemidystonia With One Eye-of-the-Tiger Sign. ( 25347119 )
2014
19
Alternating hemidystonia following traumatic brain injury as an unusual presentation of paroxysmal autonomic instability with dystonia syndrome. ( 25414239 )
2014
20
The reorganization of motor network in hemidystonia from the perspective of deep brain stimulation. ( 24728838 )
2014
21
Hemiballism-hemidystonia after parietal lobe tumour resection. ( 25128656 )
2014
22
A rat model of hemidystonia induced by 3-nitropropionic acid. ( 24194961 )
2013
23
Use of pallidal deep brain stimulation in postinfarct hemidystonia. ( 23549056 )
2013
24
Pallidal deep brain stimulation for a case of hemidystonia secondary to a striatal stroke. ( 23446229 )
2013
25
The long-term surgical outcomes of secondary hemidystonia associated with post-traumatic brain injury. ( 22367408 )
2012
26
Long-term outcome of atlas-based lesion of posterior zona incerta in secondary hemidystonia. ( 21641267 )
2011
27
Isolated hemidystonia associated with NMDA receptor antibodies. ( 21412839 )
2011
28
Hemidystonia in uncontrolled type 2 diabetes mellitus. ( 21555647 )
2011
29
Posttraumatic hemidystonia treated with unilateral globus pallidus interna stimulation: Long-term follow-up and radiologic features. ( 21992879 )
2010
30
Levodopa responsive hemidystonia associated with contralateral nigral lesion. ( 20127249 )
2010
31
Hemidystonia as an initial manifestation of leptomeningeal metastasis. ( 24868364 )
2009
32
The treatment of persistent vascular hemidystonia-hemiballismus with unilateral GPi deep brain stimulation. ( 19452565 )
2009
33
Hemidystonia-hemiatrophy syndrome. ( 19097182 )
2009
34
Hemidystonia secondary to thalamic hemorrhage treated with GPi stimulation. ( 18661563 )
2008
35
Moyamoya disease presenting with hemichoreoathetosis and hemidystonia. ( 17657809 )
2007
36
Unilateral pallidotomy for hemidystonia. ( 16534757 )
2006
37
Hemidystonia as initial manifestation of sporadic Creutzfeldt-Jakob disease. ( 16796596 )
2006
38
Psychogenic paroxysmal dyskinesia following paroxysmal hemidystonia in multiple sclerosis. ( 16186511 )
2005
39
Delayed-onset hemidystonia secondary to herpes zoster ophthalmicus-related intracerebral arteritis in an adolescent. ( 9266471 )
1997
40
Hemidystonia consequent upon ipsilateral vertebral artery occlusion and cerebellar infarction. ( 7565841 )
1995
41
Hemiatrophy, juvenile-onset exertional alternating leg paresis, hypotonia, and hemidystonia and adult-onset hemiparkinsonism: the spectrum of hemiparkinsonism-hemiatrophy syndrome. ( 7565831 )
1995
42
Ipsilateral blepharospasm and contralateral hemidystonia and parkinsonism in a patient with a unilateral rostral brainstem-thalamic lesion: structural and functional abnormalities studied with CT, MRI, and PET scanning. ( 2973558 )
1986

Variations for Hemidystonia

Expression for Hemidystonia

Search GEO for disease gene expression data for Hemidystonia.

Pathways for Hemidystonia

GO Terms for Hemidystonia

Biological processes related to Hemidystonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.58 CAMP PRKD1 TWIST1
2 response to interferon-gamma GO:0034341 9.37 GCH1 SNCA
3 synaptic vesicle transport GO:0048489 9.32 SNCA TOR1A
4 neuromuscular process controlling posture GO:0050884 9.26 GCH1 PNKD
5 negative regulation of histone acetylation GO:0035067 9.16 SNCA TWIST1
6 dopamine biosynthetic process GO:0042416 8.96 GCH1 SNCA
7 cardiac neural crest cell development involved in outflow tract morphogenesis GO:0061309 8.62 JAG1 TWIST1

Sources for Hemidystonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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