MCID: HMF004
MIFTS: 43

Hemifacial Spasm

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hemifacial Spasm

MalaCards integrated aliases for Hemifacial Spasm:

Name: Hemifacial Spasm 55 30

Classifications:



Summaries for Hemifacial Spasm

NINDS : 55 Hemifacial spasm is a neuromuscular disorder characterized by frequent involuntary contractions (spasms) of the muscles on one side (hemi-) of the face (facial). The disorder occurs in both men and women, although it more frequently affects middle-aged or elderly women. It is much more common in the Asian population.  The first symptom is usually an intermittent twitching of the eyelid muscle that can lead to forced closure of the eye. The spasm may then gradually spread to involve the muscles of the lower face, which may cause the mouth to be pulled to one side. Eventually the spasms involve all of the muscles on one side of the face almost continuously. The condition may be caused by a facial nerve injury, or a tumor, or it may have no apparent cause. Rarely, doctors see individuals with spasm on both sides of the face.  Most often hemifacial spasm is caused by a blood vessel pressing on the facial nerve at the place where it exits the brainstem.

MalaCards based summary : Hemifacial Spasm is related to hemangioma and hemifacial spasm, familial. An important gene associated with Hemifacial Spasm is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are PI3K-Akt signaling pathway and VEGF Pathway (Qiagen). The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and bone, and related phenotypes are liver/biliary system and reproductive system

Wikipedia : 77 Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle... more...

Related Diseases for Hemifacial Spasm

Diseases in the Hemifacial Spasm family:

Hemifacial Spasm, Familial

Diseases related to Hemifacial Spasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 hemangioma 29.7 FLT4 VEGFA
2 hemifacial spasm, familial 12.7
3 blepharospasm 10.9
4 trigeminal neuralgia 10.8
5 dystonia 10.5
6 facial paralysis 10.5
7 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
8 blepharospasm, benign essential 10.5
9 glossopharyngeal neuralgia 10.4
10 cervical dystonia 10.4
11 arteriovenous malformation 10.4
12 bell's palsy 10.4
13 torticollis 10.3
14 seizures, benign familial neonatal, 1 10.3
15 focal dystonia 10.3
16 multiple sclerosis 10.2
17 lipomatosis, multiple 10.2
18 pleomorphic lipoma 10.2
19 astrocytoma 10.2
20 arachnoid cysts 10.2
21 headache 10.2
22 lymphatic malformation 5 10.2
23 meningioma, familial 10.2
24 anxiety 10.2
25 spinal meningioma 10.2
26 mammary paget's disease 10.2
27 secretory meningioma 10.2
28 intracranial hypertension 10.2
29 chiari malformation 10.2
30 glioma 10.2
31 tremor 10.2
32 hydrocele 10.1 FLT4 VEGFA
33 lymphangioma 10.1 FLT4 VEGFA
34 patellar tendinitis 10.1 NOS3 VEGFA
35 chronic myocardial ischemia 10.1 NOS3 VEGFA
36 chronic mountain sickness 10.1 NOS3 VEGFA
37 lymphangiosarcoma 10.1 FLT4 VEGFA
38 angiosarcoma 10.1 FLT4 VEGFA
39 arteriovenous malformations of the brain 10.1
40 epidermoid cysts 10.1
41 neurofibromatosis, type iv, of riccardi 10.1
42 tetralogy of fallot 10.1
43 arteriovenous fistula 10.1
44 oromandibular dystonia 10.1
45 cysticercosis 10.1
46 cholesteatoma of middle ear 10.1
47 entropion 10.1
48 acoustic neuroma 10.1
49 cranial nerve palsy 10.1
50 movement disease 10.1

Graphical network of the top 20 diseases related to Hemifacial Spasm:



Diseases related to Hemifacial Spasm

Symptoms & Phenotypes for Hemifacial Spasm

MGI Mouse Phenotypes related to Hemifacial Spasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.26 FLT4 MTHFR NOS3 VEGFA
2 reproductive system MP:0005389 8.92 FLT4 MTHFR NOS3 VEGFA

Drugs & Therapeutics for Hemifacial Spasm

Drugs for Hemifacial Spasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-84-3 187
2 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Botulinum Toxins Phase 4,Phase 3,Phase 2,Not Applicable
4 Neuromuscular Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
6 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2,Not Applicable
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 abobotulinumtoxinA Phase 4,Phase 3,Phase 2,Not Applicable
9 Cholinergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Pharmaceutical Solutions Phase 4
11
Desflurane Approved 57041-67-5 42113
12
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
13
Methylcobalamin Approved, Experimental, Investigational Early Phase 1 13422-55-4
14
Zinc Approved, Investigational Not Applicable 7440-66-6 32051
15
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
16
tannic acid Approved Not Applicable 1401-55-4
17
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
18 Anesthetics ,Not Applicable
19 Anesthetics, Inhalation
20 Central Nervous System Depressants ,Not Applicable
21 Anesthetics, General
22 Zinc Supplement Not Applicable
23 Trace Elements Not Applicable
24 Micronutrients Not Applicable
25 Nutrients Not Applicable
26 Anesthetics, Local Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm Completed NCT03508882 Phase 4 Botulinum Toxin Type A 100Unit/Vial (Product);Saline Solution for Injection
2 Frontalis Botulinum Toxin Not yet recruiting NCT03186001 Phase 4 Abobotulinum toxin A
3 Assessment of Effectiveness and Safety of Dysport® for the Treatment of Hemifacial Spasm Completed NCT00276315 Phase 3 Botulinum type A toxin (Dysport®) - one single injection
4 Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm Unknown status NCT01564979 Phase 2 preseptal injection of botulinum toxin type A;pretarsal injection of Botulinum toxin type A
5 Hemifacial Spasm and Desflurane Unknown status NCT01726725 desflurane
6 Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients Unknown status NCT01271634
7 Autologous Adipose Mesenchymal Stem Cell Transplantation in the Treatment of Patients With Hemifacial Spasm Unknown status NCT02853942 Early Phase 1 Mecobalamin
8 An RCT of a Patient-initiated Treatment Service for BEB and HFS Unknown status NCT02577224 Not Applicable
9 Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm Unknown status NCT01546805 Not Applicable Zinc Supplement;Sugar pill
10 Diagnostic Test of Choice for HELPS Syndrome Unknown status NCT03126955
11 Effect of Hemifacial Spasm on Intraocular Pressure Measurement Completed NCT03390803
12 A Multicenter, Observational Study to Evaluate Clinical Manifestation, Diagnosis and Treatment of Primary Hemifacial Spasm in Chinese Patients Completed NCT01728428
13 Movement Disorder Survey in East China Completed NCT01168388
14 Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01613781 Not Applicable
15 Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01598961 Not Applicable
16 Effect of Acupuncture on Inflammation and Immune Function After Craniotomy Completed NCT02761096 Not Applicable
17 Post Marketing Surveillance Study of Dysport Completed NCT00210431
18 Botulinum Toxin A in the Treatment of Hemifacial Spasm Recruiting NCT03306940 Not Applicable Botulinum Toxin Type A
19 Blepharospasm Tools Recruiting NCT02780336
20 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Hemifacial Spasm

Genetic Tests for Hemifacial Spasm

Genetic tests related to Hemifacial Spasm:

# Genetic test Affiliating Genes
1 Hemifacial Spasm 30

Anatomical Context for Hemifacial Spasm

MalaCards organs/tissues related to Hemifacial Spasm:

42
Eye, Heart, Bone, Brain, Testes, Thalamus, Caudate Nucleus

Publications for Hemifacial Spasm

Articles related to Hemifacial Spasm:

(show top 50) (show all 1067)
# Title Authors Year
1
Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm. ( 30587995 )
2019
2
Evaluation of stigmatization in hemifacial spasm and quality of life before and after botulinum toxin treatment. ( 30178181 )
2019
3
Intraoperative Measuring of the Offending Vessel's Pressure on the Facial Nerve at Root Exit Zone in Patients with Hemifacial Spasm During Microvascular Decompression: A Prospective Study. ( 30261393 )
2019
4
Endoscope-Assisted Microvascular Decompression for the Management of Hemifacial Spasm Caused by Vertebrobasilar Dolichoectasia. ( 30278293 )
2019
5
Nervus Intermedius Section to Mobilize the Anterior Inferior Cerebellar Artery in Microvascular Decompression Surgery for Hemifacial Spasm: A Technical Case Report. ( 30476669 )
2019
6
Synchronous bilateral hemifacial spasm: case-report and literature review. ( 30511142 )
2019
7
A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. ( 30612530 )
2019
8
Preliminary Study on the Relationship Between Inflammation and Hemifacial Spasm. ( 30684712 )
2019
9
Geographic Disparities in the Surgical Management of Hemifacial Spasm in Canada. ( 30688196 )
2019
10
Hemifacial Spasm Caused by Vascular Compression in the Cisternal Portion of the Facial Nerve: Report of Two Cases with Review of the Literature. ( 30713778 )
2019
11
Revision Microvascular Decompression for Trigeminal Neuralgia and Hemifacial Spasm: Factors Associated with Surgical Failure. ( 30733898 )
2019
12
Algorithm to Predict the Outcome of Microvascular Decompression for Hemifacial Spasm: A Data-Mining Analysis Using a Decision Tree. ( 30738936 )
2019
13
The Cornerstone Technique of Microvascular Decompression for Hemifacial Spasm with Vertebral Artery Offender. ( 30743039 )
2019
14
Hemifacial spasm in sleep - A polysomnographic study. ( 30902436 )
2019
15
A Charcot Marie Tooth Type 1B Kindred Associated with Hemifacial Spasm and Trigeminal Neuralgia. ( 30920665 )
2019
16
A Rare Potential Compression Can Be Avoided by Lateral Spread Response Recordings During Microvascular Decompression for Hemifacial Spasm. ( 30921064 )
2019
17
Evaluation of Corneal Morphology in Patients With Hemifacial Spasm. ( 30946064 )
2019
18
Blink synkinesis monitoring during microvascular decompression for hemifacial spasm. ( 30946116 )
2019
19
Clinical analysis of repeat microvascular decompression for recurrent hemifacial spasm. ( 30963475 )
2019
20
Transposition of the Culprit Artery Passing Between the Facial Nerve and Auditory Nerve in Microvascular Decompression Surgery for Hemifacial Spasm. ( 30974269 )
2019
21
Prognostic value of lateral spread response during microvascular decompression for hemifacial spasm. ( 30982379 )
2019
22
Long-term Outcomes of Microvascular Decompression in the Treatment of Hemifacial Spasm Based on Different Offending Vessels. ( 31018226 )
2019
23
Treatment of Venous Hemorrhage Between Vestibulocochlear Nerve and Hypertrophic Flocculus During Microvascular Decompression Procedure for Hemifacial Spasm. ( 31022133 )
2019
24
Wedge-technique for transposition of the vertebral artery in microvascular decompression for hemifacial spasm: technical nuances and surgical outcomes. ( 31028460 )
2019
25
Validation of the Hemifacial Spasm Grading Scale: a clinical tool for hemifacial spasm. ( 31076941 )
2019
26
Hemifacial spasm and vestibular paroxysmia: Co-presence of two neurovascular compression syndromes in a patient. ( 27776966 )
2019
27
Microvascular Decompression of Facial Nerve and Pexy of the Left Vertebral Artery for Left Hemifacial Spasm: 3-Dimensional Operative Video. ( 29617905 )
2019
28
"Macrovascular" Decompression of Dolichoectatic Vertebral Artery Causing Hemifacial Spasm Using Goretex Sling: 2-Dimensional Operative Video. ( 29790968 )
2019
29
Mobilization of the Anterior/Posterior Inferior Cerebellar Artery on the Cerebellar Surface in Microvascular Decompression Surgery for Hemifacial Spasm: Potential Effect on Hearing Preservation. ( 29790978 )
2019
30
Blepharospasm and Hemifacial Spasm. ( 29239872 )
2018
31
Botulinum Toxins for Treating Essential Blepharospasm and Hemifacial Spasm. ( 29239877 )
2018
32
Surgical Myectomy for Essential Blepharospasm and Hemifacial Spasm. ( 29239878 )
2018
33
Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm. ( 29849166 )
2018
34
Severe Hemifacial Spasm is a Predictor of Severe Indentation and Facial Palsy after Microdecompression Surgery. ( 29856152 )
2018
35
Successive occurrence of vertebrobasilar dolichectasia induced trigeminal neuralgia, vestibular paroxysmia and hemifacial spasm: A case report. ( 29924039 )
2018
36
Bridging veins and veins of the brainstem in microvascular decompression surgery for trigeminal neuralgia and hemifacial spasm. ( 29961378 )
2018
37
Hemifacial Spasm in Mucopolysaccharidosis Type VI (Maroteaux-Lamy Syndrome). ( 29971196 )
2018
38
Hemodynamic features of offending vessels at neurovascular contact in patients with trigeminal neuralgia and hemifacial spasm. ( 29979116 )
2018
39
Prognosis of Symptoms and Complications After Microvascular Decompression for Hemifacial Spasm: A Single-Center Experience. ( 29981914 )
2018
40
Botulinum toxin therapy of hemifacial spasm: bilateral injections can reduce facial asymmetry. ( 29987587 )
2018
41
The Outcome of Sling Retraction Technique in Microvascular Decompression for Hemifacial Spasm. ( 30015734 )
2018
42
Involved Small Arteries in Patients Who Underwent Microvascular Decompression for Hemifacial Spasm. ( 30017761 )
2018
43
Is hemifacial spasm affected by changes in the heart rate? A study using heart rate variability analysis. ( 30033222 )
2018
44
Hemifacial spasm secondary to middle ear cholesteatoma. ( 30036421 )
2018
45
Gold thread acupuncture for hemifacial spasm. ( 30037913 )
2018
46
Clinical features and response to botulinum toxin in primary and secondary hemifacial spasm. ( 30038089 )
2018
47
Treatment of hemifacial spasm: Botulinum toxin versus microvascular decompression. ( 30038090 )
2018
48
Microvascular Decompression for Hemifacial Spasm Associated with Vertebral Artery: Biomedical Glue-Coated Teflon Sling Transposition Technique. ( 30144608 )
2018
49
Hemifacial Spasm Caused by a Vein: A Case Report. ( 30283547 )
2018
50
Prosthetic material degeneration over time as a possible factor in delayed recurrence of hemifacial spasm after successful microvascular decompression. ( 30283720 )
2018

Variations for Hemifacial Spasm

Expression for Hemifacial Spasm

Search GEO for disease gene expression data for Hemifacial Spasm.

Pathways for Hemifacial Spasm

GO Terms for Hemifacial Spasm

Biological processes related to Hemifacial Spasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.54 FLT4 NOS3 VEGFA
2 lung development GO:0030324 9.52 NOS3 VEGFA
3 positive regulation of endothelial cell proliferation GO:0001938 9.51 FLT4 VEGFA
4 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.49 FLT4 VEGFA
5 positive regulation of endothelial cell migration GO:0010595 9.48 FLT4 VEGFA
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.46 NOS3 VEGFA
7 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 FLT4 VEGFA
8 sprouting angiogenesis GO:0002040 9.4 FLT4 VEGFA
9 vascular endothelial growth factor signaling pathway GO:0038084 9.32 FLT4 VEGFA
10 tetrahydrofolate interconversion GO:0035999 9.26 MTHFR TYMS
11 tetrahydrofolate metabolic process GO:0046653 9.16 MTHFR TYMS
12 positive regulation of protein kinase C signaling GO:0090037 8.96 FLT4 VEGFA
13 response to folic acid GO:0051593 8.62 MTHFR TYMS

Molecular functions related to Hemifacial Spasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 8.96 MTHFR NOS3
2 NADP binding GO:0050661 8.62 MTHFR NOS3

Sources for Hemifacial Spasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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