MCID: HMF004
MIFTS: 40

Hemifacial Spasm

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hemifacial Spasm

MalaCards integrated aliases for Hemifacial Spasm:

Name: Hemifacial Spasm 54 29

Classifications:



Summaries for Hemifacial Spasm

NINDS : 54 Hemifacial spasm is a neuromuscular disorder characterized by frequent involuntary contractions (spasms) of the muscles on one side (hemi-) of the face (facial). The disorder occurs in both men and women, although it more frequently affects middle-aged or elderly women. It is much more common in the Asian population.  The first symptom is usually an intermittent twitching of the eyelid muscle that can lead to forced closure of the eye. The spasm may then gradually spread to involve the muscles of the lower face, which may cause the mouth to be pulled to one side. Eventually the spasms involve all of the muscles on one side of the face almost continuously. The condition may be caused by a facial nerve injury, or a tumor, or it may have no apparent cause. Rarely, doctors see individuals with spasm on both sides of the face.  Most often hemifacial spasm is caused by a blood vessel pressing on the facial nerve at the place where it exits the brainstem.

MalaCards based summary : Hemifacial Spasm is related to hemangioma and hemifacial spasm, familial. An important gene associated with Hemifacial Spasm is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are PI3K-Akt signaling pathway and VEGF Pathway (Qiagen). The drugs Pharmaceutical Solutions and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related phenotypes are liver/biliary system and reproductive system

Wikipedia : 75 Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle... more...

Related Diseases for Hemifacial Spasm

Diseases in the Hemifacial Spasm family:

Hemifacial Spasm, Familial

Diseases related to Hemifacial Spasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 hemangioma 29.7 VEGFA FLT4
2 hemifacial spasm, familial 13.0
3 blepharospasm 11.0
4 trigeminal neuralgia 11.0
5 facial paralysis 10.9
6 facial spasm 10.8
7 dystonia 10.8
8 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.8
9 ptosis 10.7
10 movement disease 10.7
11 pica disease 10.7
12 branchiootic syndrome 1 10.6
13 blepharospasm, benign essential 10.6
14 cervical dystonia 10.6
15 meningioma, radiation-induced 10.6
16 meningioma, familial 10.6
17 spinal meningioma 10.6
18 bell's palsy 10.6
19 secretory meningioma 10.6
20 lymphoplasmacyte-rich meningioma 10.6
21 focal dystonia 10.5
22 glossopharyngeal neuralgia 10.5
23 torticollis 10.5
24 sensorineural hearing loss 10.5
25 arteriovenous malformation 10.5
26 seizures, benign familial neonatal, 1 10.5
27 neurilemmoma 10.5
28 lipomatosis, multiple 10.4
29 arthrogryposis, mental retardation, and seizures 10.4
30 oromandibular dystonia 10.4
31 pleomorphic lipoma 10.4
32 47,xyy 10.4
33 cerebrospinal fluid leak 10.4
34 chiari malformation 10.4
35 aneurysm 10.4
36 acoustic neuroma 10.4
37 myoclonus 10.4
38 rare surgical neurologic disease 10.4
39 epidermoid cysts 10.3
40 lymphatic malformation 5 10.3
41 tic disorder 10.3
42 mammary paget's disease 10.3
43 cranial nerve palsy 10.3
44 arachnoid cysts 10.3
45 headache 10.3
46 migraine with or without aura 1 10.3
47 hydrocephalus 10.3
48 lagophthalmos 10.3
49 congenital hydrocephalus 10.3
50 dysphagia 10.3

Graphical network of the top 20 diseases related to Hemifacial Spasm:



Diseases related to Hemifacial Spasm

Symptoms & Phenotypes for Hemifacial Spasm

MGI Mouse Phenotypes related to Hemifacial Spasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.26 FLT4 MTHFR NOS3 VEGFA
2 reproductive system MP:0005389 8.92 FLT4 MTHFR NOS3 VEGFA

Drugs & Therapeutics for Hemifacial Spasm

Drugs for Hemifacial Spasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4
2
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
3 Neurotransmitter Agents Phase 3
4 abobotulinumtoxinA Phase 3
5 Neuromuscular Agents Phase 3
6 Cholinergic Agents Phase 3
7 Acetylcholine Release Inhibitors Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Botulinum Toxins Phase 3
10 Botulinum Toxins, Type A Phase 3
11
Methylcobalamin Approved, Experimental, Investigational Early Phase 1 13422-55-4
12
Desflurane Approved 57041-67-5 42113
13
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
14
Zinc Approved, Investigational 7440-66-6 32051
15
tannic acid Approved 1401-55-4
16
Sevoflurane Approved, Vet_approved 28523-86-6 5206
17
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
18 Anesthetics, General
19 Anesthetics, Inhalation
20 Micronutrients
21 Nutrients
22 Zinc Supplement
23 Trace Elements
24 Central Nervous System Depressants
25 Anesthetics
26 Anesthetics, Local
27 Lidocaine, Prilocaine Drug Combination

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 DOUBLE BLIND, PLACEBO CONTROLLED, RANDOMIZED CLINICAL TRIAL OF THE SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A (BOTOX) IN BRUXISM Unknown status NCT00908050 Phase 4 Botulinum toxin type A
2 The Impact of Botulinum Toxin Injection in the Frontalis on Brow Height and Morphology: A Randomized Trial Unknown status NCT03186001 Phase 4 Abobotulinum toxin A
3 Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm: a Randomized, Triple-blind, Placebo-controlled, Cross-over Clinical Trial Completed NCT03508882 Phase 4 Botulinum Toxin Type A 100Unit/Vial (Product);Saline Solution for Injection
4 A Phase III, Multicentre, Randomised, Assessor-blind, Parallel Groups, Reference Drug Controlled Study to Assess the Efficacy and Safety of a Single Administration, by Subcutaneous Injection of Dysport® for the Treatment of Hemifacial Spasm Completed NCT00276315 Phase 3
5 A 48-Week Prospective, Double-Blinded, Randomized, Cross-over Design in Multicenter Study of 250 Unit of Dysport Versus 50 Unit of Neuronox Injection For Cervical Dystonia in Thai Patients Not yet recruiting NCT03805152 Phase 3 Neuronox(R);Dysport (R)
6 Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm Unknown status NCT01564979 Phase 2 preseptal injection of botulinum toxin type A;pretarsal injection of Botulinum toxin type A
7 Observation of the Abnormal Potential From the Offending Vessel to the Facial Muscles of Hemifacial Spasm Patients Unknown status NCT01271634
8 The Research of Autologous Adipose Mesenchymal Stem Cell Transplantation for Treatment of Facial 、Auditory Nerve Dysfunction of Patients With Hemifacial Spasm After Microvascular Decompression. Unknown status NCT02853942 Early Phase 1 Mecobalamin
9 Investigating the Etiology of Hemifacial Spasm (HFS): The Role of Desflurane Unknown status NCT01726725 desflurane
10 The Effect of Zinc Supplementation on the Efficacy and Duration of Botulinum Toxin for the Treatment of Oculofacial Spasm Disorders Unknown status NCT01546805 Zinc Supplement;Sugar pill
11 A Randomised Controlled Trial to Explore the Effectiveness and Cost-effectiveness of a Patient-initiated Botulinum Toxin Treatment Model for Blepharospasm and Hemifacial Spasm Compared to Treatment as Usual Unknown status NCT02577224
12 Microvascular Decompression for HELPS Syndrome: What is the Best Diagnostic Test? Unknown status NCT03126955
13 A Multicenter, Observational Study to Evaluate Clinical Manifestation, Diagnosis and Treatment of Primary Hemifacial Spasm in Chinese Patients Completed NCT01728428
14 Effect of Hemifacial Spasm on Intraocular Pressure Measurement Completed NCT03390803
15 Movement Disorder Survey in East China Completed NCT01168388
16 A Post Marketing Surveillance Study of Dysport Formulated With a Batch of Bulk Active Substance From a New Primary Manufacturing Facility at the Centre for Applied Microbiology & Research. Completed NCT00210431
17 Determination of Target of Adequate Partial Neuromuscular Blockade With Sevoflurane Anesthesia for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01613781
18 Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01598961
19 Effect of Acupuncture on Inflammation and Immune Function After Craniotomy Completed NCT02761096
20 Assessment The Effects of Proprioceptive Neuromuscular Facilitation, Myofascial Releasing Maneuvers and Home Exercises on Pain and Jaw Function in Patients With Bruxism Completed NCT03499665
21 Does Bilateral Botulinum Toxin A in Patients With Hemifacial Spasm Improve Facial Symmetry Unilateral and Bilateral Injection of Botulinum Toxin A in Patients With Hemifacial Spasm? A Prospective, Randomized, Controlled Study Recruiting NCT03306940 Botulinum Toxin Type A
22 Jitter's Recording in a Spastic Muscle Treated by Botulinum Toxin Not yet recruiting NCT04002843
23 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Hemifacial Spasm

Genetic Tests for Hemifacial Spasm

Genetic tests related to Hemifacial Spasm:

# Genetic test Affiliating Genes
1 Hemifacial Spasm 29

Anatomical Context for Hemifacial Spasm

MalaCards organs/tissues related to Hemifacial Spasm:

41
Eye, Brain, Bone, Testes, Heart, Skin, Pons

Publications for Hemifacial Spasm

Articles related to Hemifacial Spasm:

(show top 50) (show all 1906)
# Title Authors PMID Year
1
Missed Culprits in Failed Microvascular Decompression Surgery for Hemifacial Spasm and Clinical Outcomes of Redo Surgery. 38
31158550 2019
2
Endovascular Flow Diversion for Hemifacial Spasm Induced by a Vertebral Artery Aneurysm: First Experience. 38
30476260 2019
3
Surgical effect and electrophysiological study of patients with hemifacial spasm treated with botulinum toxin or acupuncture before microvascular decompression. 38
31351214 2019
4
Ocular surface status in patients with hemifacial spasm under long-lasting treatment with botulinum A toxin: A comparative fellow eye study. 38
31436182 2019
5
Combined Hyperactive Dysfunction Syndrome of the Cranial Nerves: Analysis of 37 Cases and Literature Review. 38
31158546 2019
6
Surgical Outcomes of Revision Microvascular Decompression for Persistent or Recurrent Hemifacial Spasm after Surgery: Analysis of radiological and intraoperative findings. 38
31382068 2019
7
Delayed hearing loss after microvascular decompression for hemifacial spasm-an unsolved conspiracy of the cochlear apparatus. 38
31152242 2019
8
Short-term versus long-term outcomes of microvascular decompression for hemifacial spasm. 38
31392569 2019
9
Brainstem lesion causing paroxysmal ataxia, dysarthria, diplopia and hemifacial spasm (PADDHS). 38
31371274 2019
10
A charcot-marie-tooth type 1B kindred associated with hemifacial spasm and trigeminal neuralgia. 38
30920665 2019
11
Outcomes and Safety of Overlapping Surgery in Patients Undergoing Microvascular Decompression for Hemifacial Spasm and Trigeminal Neuralgia. 38
31323398 2019
12
Wedge-technique for transposition of the vertebral artery in microvascular decompression for hemifacial spasm: technical nuances and surgical outcomes. 38
31028460 2019
13
Long-term Outcomes of Microvascular Decompression in the Treatment of Hemifacial Spasm Based on Different Offending Vessels. 38
31018226 2019
14
Transposition of the Culprit Artery Passing Between the Facial Nerve and Auditory Nerve in Microvascular Decompression Surgery for Hemifacial Spasm. 38
30974269 2019
15
Treatment of Venous Hemorrhage Between Vestibulocochlear Nerve and Hypertrophic Flocculus During Microvascular Decompression Procedure for Hemifacial Spasm. 38
31299771 2019
16
Loop characteristics and audio-vestibular symptoms or hemifacial spasm: is there a correlation? A multiplanar MRI study. 38
31338653 2019
17
Hemifacial Spasm Caused by Small Epidermoid Tumor, Misinterpreted as Delayed Secondary Hemifacial Spasm Caused by Vestibular Schwannoma Treated with Gamma Knife Surgery. 38
31349082 2019
18
A rare case of unilateral hemifacial spasm and facial palsy associated with an abnormal anatomical variant of the posterior basilar circulation. 38
31155905 2019
19
Endoscope-assisted retrosigmoid approach in hemifacial spasm: our experience. 38
29784621 2019
20
Intraoperative Neurophysiological Monitoring during Microvascular Decompression Surgery for Hemifacial Spasm. 38
31290293 2019
21
Evaluation of Corneal Morphology in Patients With Hemifacial Spasm. 38
30946064 2019
22
In vitro and in vivo experiments of a novel intra-arterial neurovascular decompressor for treating neurovascular compression syndromes: a brief report. 38
31044660 2019
23
Utilization of 3D imaging reconstructions and assessment of symptom-free survival after microvascular decompression of the facial nerve in hemifacial spasm. 38
31299649 2019
24
The long-term effects of microvascular decompression on social phobia and health-related quality of life in patients with hemifacial spasm: a 3-year prospective study. 38
31368052 2019
25
A Unique Case of Microvascular Triple Decompression for Combined Simultaneous Trigeminal Neuralgia, Hemifacial Spasm, and Glossopharyngeal Neuralgia Because of the Dolichoectatic Vertebrobasilar System. 38
31334555 2019
26
How I do it: 3D exoscopic endoscope-assisted microvascular decompression. 38
31144166 2019
27
Consensus of the Iberoamerican Oculoplastic Society for diagnosis and management of facial dystonia. 38
31272707 2019
28
Blink synkinesis monitoring during microvascular decompression for hemifacial spasm. 38
30946116 2019
29
Hemifacial spasm in sleep - A polysomnographic study. 38
30902436 2019
30
Retrosigmoid Craniotomy for the Removal of Left Sided Tentorial and Posterior Fossa Meningioma Combined with Microvascular Decompression for Hemifacial Spasm. 38
31143598 2019
31
Comparison of techniques of botulinum toxin injections for blepharospasm and hemifacial spasm. 38
31251420 2019
32
[Clinical study of microvascular decompression in patients with coexistent hemifacial spasm and ipsilateral trigeminal neuralgia]. 38
31207692 2019
33
Endoscopic-Assisted Microvascular Decompression of Ectatic Vertebral Artery for Hemifacial Spasm: Operative Video and Technical Nuances. 38
31143608 2019
34
Lateral Basal Approach to CPA in Supine No-Retractor Method: Microvascular Decompression for Hemifacial Spasm. 38
31143611 2019
35
Absence of Ischemic Injury after Sacrificing the Superior Petrosal Vein during Microvascular Decompression. 38
31214696 2019
36
Vascular Complications in Microvascular Decompression: A Survey of 4000 Operations. 38
31254687 2019
37
Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events. 38
31207376 2019
38
[Botulinumtoxin in Ophthalmology]. 38
30999362 2019
39
[Study on the relationship between preoperative evaluation, operation and prognosis of microvascular decompression for the treatment of hemifacial spasm]. 38
31091581 2019
40
Validation of the Hemifacial Spasm Grading Scale: a clinical tool for hemifacial spasm. 38
31076941 2019
41
Pseudoaneurysm presenting around polytetrafluoroethylene fiber following microvascular decompression: A case report and literature review. 38
30732984 2019
42
Writing, reading, and speaking in blepharospasm. 38
30783748 2019
43
Adverse Events After Microvascular Decompression: A National Surgical Quality Improvement Program Analysis. 38
31082546 2019
44
Clinical analysis of repeat microvascular decompression for recurrent hemifacial spasm. 38
30963475 2019
45
[Therapy of Hemifacial Spasm with Botulinum Toxin]. 38
30968378 2019
46
Treatment of Venous Hemorrhage Between Vestibulocochlear Nerve and Hypertrophic Flocculus During Microvascular Decompression Procedure for Hemifacial Spasm. 38
31022133 2019
47
A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. 38
30612530 2019
48
Prognostic value of lateral spread response during microvascular decompression for hemifacial spasm. 38
30982379 2019
49
[Clinical application of endoscope combined with microscope for the microvascular decompression in hemifacial spasm]. 38
30991776 2019
50
Hemifacial spasm and vestibular paroxysmia: Co-presence of two neurovascular compression syndromes in a patient. 38
27776966 2019

Variations for Hemifacial Spasm

Expression for Hemifacial Spasm

Search GEO for disease gene expression data for Hemifacial Spasm.

Pathways for Hemifacial Spasm

GO Terms for Hemifacial Spasm

Biological processes related to Hemifacial Spasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.54 VEGFA NOS3 FLT4
2 lung development GO:0030324 9.52 VEGFA NOS3
3 positive regulation of endothelial cell proliferation GO:0001938 9.51 VEGFA FLT4
4 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.49 VEGFA FLT4
5 positive regulation of endothelial cell migration GO:0010595 9.48 VEGFA FLT4
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.46 VEGFA NOS3
7 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 VEGFA FLT4
8 sprouting angiogenesis GO:0002040 9.4 VEGFA FLT4
9 vascular endothelial growth factor signaling pathway GO:0038084 9.32 VEGFA FLT4
10 tetrahydrofolate metabolic process GO:0046653 9.26 TYMS MTHFR
11 tetrahydrofolate interconversion GO:0035999 9.16 TYMS MTHFR
12 response to folic acid GO:0051593 8.96 TYMS MTHFR
13 positive regulation of protein kinase C signaling GO:0090037 8.62 VEGFA FLT4

Molecular functions related to Hemifacial Spasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 8.96 NOS3 MTHFR
2 NADP binding GO:0050661 8.62 NOS3 MTHFR

Sources for Hemifacial Spasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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