Aliases & Classifications for Hemiplegia

MalaCards integrated aliases for Hemiplegia:

Name: Hemiplegia 12 73 6 44 15 17 32
Postnatal Infantile Hemiplegia 12
Hemiplegia, Infantile 70
Infantile Hemiplegia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10969
ICD9CM 34 343.4
MeSH 44 D006429
SNOMED-CT 67 155024003
ICD10 32 G81 G81.9
UMLS 70 C0392550

Summaries for Hemiplegia

Disease Ontology : 12 A central nervous system disease that is characterized by the complete paralysis of half of the body.

MalaCards based summary : Hemiplegia, also known as postnatal infantile hemiplegia, is related to alternating hemiplegia of childhood 1 and brain small vessel disease 1 with or without ocular anomalies. An important gene associated with Hemiplegia is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are Pathways in cancer and Circadian entrainment. The drugs Baclofen and GABA Agonists have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and cortex, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 73 Hemiparesis, or unilateral paresis, is weakness of one entire side of the body (hemi- means "half").... more...

Related Diseases for Hemiplegia

Diseases related to Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 611)
# Related Disease Score Top Affiliating Genes
1 alternating hemiplegia of childhood 1 32.9 ATP1A3 ATP1A2
2 brain small vessel disease 1 with or without ocular anomalies 32.6 COL4A2 COL4A1
3 episodic ataxia, type 6 31.7 SLC1A3 SLC1A1 CACNA1A
4 familial hemiplegic migraine 31.5 SLC1A3 SCN1A CALCA CACNA1A ATP1A3 ATP1A2
5 alternating hemiplegia of childhood 31.4 TAC1 SLC2A1 SLC1A3 SCN1A PNKD MMP9
6 status epilepticus 30.9 SCN1A ENO2 CACNA1A
7 dystonia 12 30.9 SLC2A1 CACNA1A ATP1A3
8 episodic ataxia 30.8 SLC1A3 SLC1A1 SCN1A PNKD CACNA1A ATP1A3
9 seizure disorder 30.8 TBC1D24 SLC2A1 SCN1A ATP1A3 ATP1A2
10 algoneurodystrophy 30.7 TAC1 CALCA
11 head injury 30.5 S100B ENO2
12 headache 30.4 TAC1 SCN1A CALCA CACNA1A ATP1A2
13 reflex sympathetic dystrophy 30.3 TAC1 CALCA
14 epilepsy 30.3 TBC1D24 SLC2A1 SLC1A1 SCN1A S100B CACNA1A
15 migraine with or without aura 1 30.1 TAC1 SLC1A3 SCN1A S100B COL4A1 CALCA
16 west syndrome 30.1 TBC1D24 SLC2A1 SCN1A CACNA1A
17 dystonia 30.1 TBC1D24 SLC2A1 PNKD CACNA1A ATP1A3 ADCY5
18 migraine, familial hemiplegic, 1 30.1 SLC1A3 SCN1A CACNA1A ATP1A2
19 early myoclonic encephalopathy 30.1 TBC1D24 SLC2A1 SCN1A CACNA1A
20 migraine, familial hemiplegic, 2 30.0 SLC1A3 SCN1A CACNA1A ATP1A3 ATP1A2
21 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 30.0 COL4A2 COL4A1 ATP1A2
22 early infantile epileptic encephalopathy 30.0 TBC1D24 SLC2A1 SCN1A CACNA1A ATP1A3 ATP1A2
23 focal epilepsy 29.9 TBC1D24 SLC2A1 SCN1A
24 col4a1-related familial vascular leukoencephalopathy 29.9 COL4A2 COL4A1
25 lennox-gastaut syndrome 29.9 SLC2A1 SCN1A CACNA1A
26 leukoencephalopathy, hereditary diffuse, with spheroids 29.8 SLC1A3 SCN1A S100B
27 akinetic mutism 29.7 S100B ENO2
28 movement disease 29.7 TBC1D24 TAC1 SLC2A1 PNKD CACNA1A ATP1A3
29 patent foramen ovale 29.6 SCN1A RNF213 MYH6 COL4A1 ATP1A2
30 dravet syndrome 29.6 TBC1D24 SLC2A1 SCN1A CACNA1A ATP1A2
31 choreatic disease 29.5 TAC1 SLC2A1 PNKD CACNA1A ATP1A3 ADCY5
32 hepatic encephalopathy 29.4 SLC1A1 S100B MMP9
33 episodic ataxia, type 2 29.3 SCN1A PNKD CACNA1A ATP1A2
34 migraine with aura 29.2 TAC1 SLC2A1 SLC1A3 SCN1A CALCA CACNA1A
35 peripheral nervous system disease 29.1 TAC1 S100B MMP9 ENO2 CALCA
36 benign epilepsy with centrotemporal spikes 29.0 TBC1D24 SLC2A1 SCN1A PNKD CACNA1A ATP1A2
37 tetralogy of fallot 28.9 MYH6 MMP9 ENO2 CALCA
38 spastic hemiplegia 11.6
39 alternating hemiplegia of childhood 2 11.5
40 idiopathic hemiconvulsion-hemiplegia syndrome 11.5
41 hemiplegia alterans 11.3
42 familial porencephaly 11.3
43 medial medullary syndrome 11.1
44 porencephaly 11.0
45 epileptic hemiplegia 11.0
46 brain small vessel disease 2 11.0
47 mitochondrial complex v deficiency, nuclear type 6 11.0
48 brown-sequard syndrome 11.0
49 benign nocturnal alternating hemiplegia of childhood 11.0
50 moyamoya disease 1 10.9

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to Hemiplegia

Symptoms & Phenotypes for Hemiplegia

UMLS symptoms related to Hemiplegia:


hemiplegia

MGI Mouse Phenotypes related to Hemiplegia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ADCY5 ATP1A2 ATP1A3 CACNA1A COL4A1 ENO2
2 growth/size/body region MP:0005378 10.07 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 ENO2
3 homeostasis/metabolism MP:0005376 10.03 ADCY5 ATP1A2 ATP1A3 BGLAP CACNA1A COL4A1
4 nervous system MP:0003631 9.77 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 ENO2
5 respiratory system MP:0005388 9.28 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 ENO2

Drugs & Therapeutics for Hemiplegia

Drugs for Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Baclofen Approved Phase 4 1134-47-0 2284
2 GABA Agonists Phase 4
3 Botulinum Toxins Phase 3
4
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
5
Sodium oxybate Approved Phase 1, Phase 2 502-85-2 5360545
6
Glycerol Approved, Investigational Phase 2 56-81-5 753
7 Carbon Fiber Phase 1, Phase 2
8 Anti-Arrhythmia Agents Phase 2
9 Sodium Channel Blockers Phase 2
10 Anesthetics Phase 2
11 Anesthetics, Local Phase 2
12 Diuretics, Potassium Sparing Phase 2
13 Protective Agents Phase 2
14 Anesthetics, General Phase 1, Phase 2
15 Anesthetics, Intravenous Phase 1, Phase 2
16
Acetylcholine Approved, Investigational 51-84-3 187
17
Methamphetamine Approved, Illicit 537-46-2 10836
18
Dopamine Approved 62-31-7, 51-61-6 681
19
Fluoxetine Approved, Vet_approved 54910-89-3 3386
20 Raspberry Approved
21
tannic acid Approved 1401-55-4
22
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
23
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
24
Betamethasone Approved, Vet_approved 378-44-9 9782
25
Frovatriptan Approved, Investigational 158747-02-5 77992
26
Sodium citrate Approved, Investigational 68-04-2
27
Prednisolone acetate Approved, Vet_approved Early Phase 1 52-21-1
28
Prednisolone Approved, Vet_approved Early Phase 1 50-24-8 5755
29
Methylprednisolone Approved, Vet_approved Early Phase 1 83-43-2 6741
30
Prednisolone phosphate Approved, Vet_approved Early Phase 1 302-25-0
31
Methylprednisolone hemisuccinate Approved Early Phase 1 2921-57-5
32
Metronidazole Approved 443-48-1 4173
33
Flumazenil Approved 78755-81-4 3373
34
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
35
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
36
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
37
Prednisolone hemisuccinate Experimental Early Phase 1 2920-86-7
38 Complement C3
39 Cholinergic Agents
40 Central Nervous System Stimulants
41 Dopamine Agents
42 Sympathomimetics
43 Adrenergic Agents
44 Dopamine Uptake Inhibitors
45 Psychotropic Drugs
46 Antidepressive Agents
47 Cytochrome P-450 Enzyme Inhibitors
48 Serotonin Uptake Inhibitors
49 Betamethasone Valerate 2152-44-5
50 Betamethasone benzoate

Interventional clinical trials:

(show top 50) (show all 210)
# Name Status NCT ID Phase Drugs
1 Functional Electrical Stimulation (FES)-Assisted Walking: Enhancement of Voluntary Walking Function Among Persons With Severe Hemiplegia Post-Stroke Unknown status NCT00552916 Phase 4
2 Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing the Antispastic Efficacy and Safety of Dynamic Night Hand Splinting in Adults With Post-stroke Hemiplegia Treated by Botulimum Toxin (Dysport®) - (a Pilot Study) Unknown status NCT02888548 Phase 4
3 Research Assistant Doctor Unknown status NCT03860662 Phase 4 Botox;Baclofen
4 Multi-center, Single Arm, Open-label, Phase IV Clinical Trial to Evaluate the Safety and Efficacy of MEDITOXIN® in Children With Cerebral Palsy Completed NCT01256021 Phase 4 Botulinum Toxin Type A
5 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Unknown status NCT03216837 Phase 2, Phase 3
6 Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
7 Double-blinded, Randomized, Active Control Comparative, Multicenter-designed, Phase III Clinical Trial to Evaluate the Safety and Efficacy of "Botulax®" Versus "Botox®" in Children With Cerebral Palsy Completed NCT01787344 Phase 3 Botulinum Toxin Type A(Botox®);Botulinum toxin type A(Botulax®)
8 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
9 Assisted Movement Neuro-rehabilitation: VA Multi-site Clinical Trial Completed NCT00223808 Phase 3
10 Is it Possible to Improve Static and Dynamic Postural Stability in Cerebral Palsy Children by Modulating Attention? Completed NCT01799304 Phase 3
11 Randomised Controlled Trial to Evaluate the Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity (Repeated Botulinum Toxin Injections and Physiotherapy) on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Recruiting NCT02944929 Phase 3
12 Burke-Hocoma Efficiency Study Enrolling by invitation NCT03555825 Phase 3
13 Effects of the Quantity of Repetitive Transcranial Magnetic Stimulation on the Recovery of Upper Motor Function After Stroke: a Randomized Controlled Trial Terminated NCT01311271 Phase 2, Phase 3
14 Randomized Clinical Trial of Hand Arm Bimanual Intensive Therapy (HABIT) Unknown status NCT01413594 Phase 1, Phase 2
15 Effet de la réadaptation Sur Les déficiences, Limitations d'activité et Restriction de la Participation Des Enfants présentant Des lésions Neurologiques Non-évolutives (Infirmes Moteurs cérébraux). Unknown status NCT01700777 Phase 1, Phase 2
16 Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction After Stroke Unknown status NCT01010607 Phase 1, Phase 2
17 Rehabilitation of Early Stroke Patients Using a Custom-made Solid Ankle-foot Orthosis: a Randomised Controlled Trial Unknown status NCT01006772 Phase 1, Phase 2
18 Evaluation of Therapeutic Effects of Navigation-guided 1 Hz rTMS Administered to the Contralesional Hemisphere in Patients With Stroke Completed NCT01049802 Phase 1, Phase 2
19 Contralaterally Controlled Functional Electrical Stimulation for Hemiparetic Hand Completed NCT00565045 Phase 1, Phase 2
20 Suprascapular Nerve Block in Hemiplegic Shoulder Pain. Completed NCT00732589 Phase 2 1% xylocaine
21 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity in the Affected Leg of Hemiplegics Completed NCT01569386 Phase 2
22 Auditory Rhythm Cues + Task Practice: Effects on UE Motor Function Post-stroke Completed NCT00523523 Phase 1, Phase 2
23 A Phase 2 Study of HC-58 in Patients With Severe Upper Limb Hemiplegia After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
24 Single-center Phase I/II Trial of Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO Trial) Completed NCT00931164 Phase 1, Phase 2 Sodium Oxybate
25 "Etude Pilote, Comparative, Monocentrique, randomisée, en Cross Over, en Double Aveugle, Contre Placebo, Testant l'efficacité de l'Huile triheptanoïne Dans Les Hémiplégies Alternantes de l'Enfant" HEMIHEP Completed NCT02408354 Phase 2 Triheptanoin;Placebo
26 Subacute Stroke Recovery (Upper Extremity Motor Function): Bimanual Coordination Training Completed NCT00369668 Phase 2
27 Home Based Tele-exercise for People With Chronic Neurological Impairments Recruiting NCT04564495 Phase 1, Phase 2
28 Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy Unknown status NCT00305006 Phase 1
29 Pediatric Hemiplegia: Synergistic Treatment Using rTMS and CIT Completed NCT01104064 Phase 1
30 Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments Completed NCT01072461 Phase 1
31 Different Dilutions and Efficacy of Botulin Toxin in the Correction of the Hemiplegic Gait Recruiting NCT04630873 Phase 1 Botulinum toxin
32 Efficacy of Transcranial Laser Therapy for Improving Upper Extremity Functional Recovery in Hemiplegic Patients From Ischemic Stroke Terminated NCT01308216 Phase 1
33 Automatic Versus Intentional Movement Exercises to Enhance Arm Functions After Stroke Unknown status NCT01565044
34 Functional Electrical Stimulation Therapy for Children With Upper Limb Weakness Post Stroke: Evaluation of the Mynd Move Technology Unknown status NCT03147794
35 A Multi-site, Interventional, Non-comparative, Single-arm Trial to Evaluate the Safety of the ReWalk ReStore Device in Subjects With Mobility Impairments Due to Ischemic or Hemorrhagic Stroke Unknown status NCT03499210
36 Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia Unknown status NCT02918890
37 The Use of Ultrasound for Botulinum Toxin Subscapularis Muscle Injection Guidance in Spastic Hemiplegic Shoulder Pain Unknown status NCT03621423
38 Constraint Induced Movement Therapy (CIMT) in Babies Home Program Unknown status NCT01214902
39 Reliability of Kinematic Analysis in Assessment and Rehabilitation of the Upper Arm of Stroke Patients Following a Cerebral Vascular Accident, Hemiparetic Subjects Unknown status NCT02326688
40 Neuromuscular Electrical Stimulation (NMES) Applied to Back Extensors in Stroke Patients; Effects on Functional Capacity and Mobility Unknown status NCT03811106
41 Study on the Effectiveness of Action Observation Treatment (AOT) as a Rehabilitation Tool in Acute Stroke Patients and in Chronic Stroke Patients With Apraxia: a Randomized Controlled Trial Unknown status NCT02235350
42 Continuation of the Exploration of the Standing Seated Passage of the Hemiplegic for the Realization of a New Transport Device Unknown status NCT03117699
43 A Clinical Observational Follow-up Study of European Pediatric Cases of Acute Flaccid Myelitis Associated With EV-D68 Infection. Unknown status NCT03499366
44 Tele-rehabilitation in the Home With Gaming as a Method of Improving Upper Extremity Function After Stroke Unknown status NCT02494362
45 Cardiopulmonary Rehabilitation in Chronic Stroke Patients Unknown status NCT03558542
46 Cardiovascular Function in Sub Maximal Exercise and Performance in Three Daily Activity Tests in Persons With Post Stroke Conditions Unknown status NCT01396746
47 The Effect of Combined Armeospring Pediatric and Constraint Induced Therapy on Neuro-motor and Functional Recovery in Children With Unilateral Cerebral Palsy Unknown status NCT02914925
48 Modified Constraint Induced Movement Therapy and Bimanual Intensive Therapy in Children With Hemiplegia. Comparative Study Completed NCT03465046
49 Motor Outcomes and Neural Correlates of Asymmetrical Gait Training in Children With Acquired Hemiplegia Completed NCT01827436 Early Phase 1
50 An Evaluation of the Effectiveness of Functional Electrical Stimulation Paired With Intensive Therapy to Improve Hand Function in Children With Hemiplegic Cerebral Palsy Completed NCT03016923

Search NIH Clinical Center for Hemiplegia

Cochrane evidence based reviews: hemiplegia

Genetic Tests for Hemiplegia

Anatomical Context for Hemiplegia

MalaCards organs/tissues related to Hemiplegia:

40
Brain, Bone, Cortex, Heart, Spinal Cord, Skin, Pituitary

Publications for Hemiplegia

Articles related to Hemiplegia:

(show top 50) (show all 7878)
# Title Authors PMID Year
1
Cerebral venous sinus thrombosis in patients with COVID-19 infection. 61
33520667 2021
2
A Clinical Practice Guideline for the Use of Ankle-Foot Orthoses and Functional Electrical Stimulation Post-Stroke. 61
33675603 2021
3
Rapid-onset dystonia-parkinsonism with ATP1A3 mutation and left lower limb paroxysmal dystonia. 61
33451880 2021
4
De novo ATP1A2 variants in two Chinese children with alternating hemiplegia of childhood upgraded the gene-disease relationship and variant classification: a case report. 61
33794876 2021
5
An Adult Case of Hemiplegia, Aphasia, and Hemispheric Atrophy Associated with Febrile Status Epilepticus. 61
33116007 2021
6
Assessment of Karnofsky (KPS) and WHO (WHO-PS) performance scores in brain tumour patients: the role of clinician bias. 61
32789684 2021
7
Distal Radius Fracture Treatment Outcomes in Patients With Ipsilateral Hemiplegia or Hemiparesis. 61
33789515 2021
8
Asymmetry and Variability Should Be Included in the Assessment of Gait Function in Poststroke Hemiplegia With Independent Ambulation During Early Rehabilitation. 61
33161006 2021
9
[Clinical and genetic analysis of 5 pediatric patients with hemiplegic migraine presenting as acute encephalopathy]. 61
33775052 2021
10
Usefulness of a single-parameter tool for the prediction of large vessel occlusion in acute stroke. 61
33145651 2021
11
Late-onset cerebral arteriopathy in a patient with incontinentia pigmenti. 61
33419638 2021
12
Rehabilitating the neurological patient in the ICU: what is important? 61
33395083 2021
13
Ipsilateral Reversible Cerebral Vasculopathy Secondary to Carotid Artery Revascularization: A Case Report. 61
33791063 2021
14
Hypothalamic-pituitary dysfunction in alternating hemiplegia of childhood. 61
33756210 2021
15
Risk of a complete exchange or failure in total knee arthroplasty and unicompartmental knee arthroplasty: a nationwide population-based cohort study from South Korea. 61
33184700 2021
16
The Effects of Upper Extremity Isokinetic Strengthening in Post-Stroke Hemiplegia: A Randomized Controlled Trial. 61
33765633 2021
17
Rare severe hypofibrinogenemia induced by tissue plasminogen activator in stroke patients: Case report. 61
33655967 2021
18
Adult-onset neuronal intranuclear inclusion disease, with both stroke-like onset and encephalitic attacks: a case report. 61
33789591 2021
19
Contrast-induced encephalopathy mimicking total anterior circulation stroke: a case report and review of the literature. 61
33089478 2021
20
Emergent stenting after intravenous thrombolysis for isolated basilar artery dissection in a patient with acute ischemic stroke: a case report. 61
33685504 2021
21
Clinical effectiveness of peroneal nerve functional electrical stimulation in chronic stroke patients with hemiplegia (PLEASURE): A multicentre, prospective, randomised controlled trial. 61
33103916 2021
22
Performance Analysis in Football-Specific Tests by Para-Footballers With Cerebral Palsy: Implications for Evidence-Based Classification. 61
33662930 2021
23
RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood. 61
33504645 2021
24
De novo ATP1A3 variants cause polymicrogyria. 61
33762331 2021
25
Validity of quantitative assessment of posterior pelvic tilt and contralateral vaulting in hemiplegia using 3D treadmill gait analysis. 61
32588758 2021
26
Macrosquare-wave jerks subsiding after hydrocephalus treatment in a thalamic hemorrhage patient. 61
33642490 2021
27
Microsomic and macrosomic body structure in children and adolescents affected by syndromes or diseases associated with neurodysfunction. 61
33737592 2021
28
Neuroradiologic Features Associated With Severe Restriction of Functional Mobility in Children With Cerebral Palsy in North India. 61
33709827 2021
29
[Nonconvulsive Status Epilepticus Associated with Theophylline: A Case Report]. 61
33678620 2021
30
Y-configuration double-stent-retriever thrombectomy for refractory thrombus in middle cerebral artery bifurcation: A case report. 61
33725971 2021
31
Updated perspectives on awake neurosurgery with cognitive and emotional assessment for patients with low-grade gliomas. 61
33724148 2021
32
Clinical Features and Risk Factors for In-Hospital Mortality From COVID-19 Infection at a Tertiary Care Medical Center, at the Onset of the US COVID-19 Pandemic. 61
33759606 2021
33
Is the retrograde access for endovascular treatment of a traumatic carotid cavernous fistula associated with dissection of the ipsilateral carotid possible? 61
33725761 2021
34
Anosognosia for limb and bucco-facial apraxia as inferred from the recognition of gestural errors. 61
32080980 2021
35
Effect of 'hand and foot acupuncture with twelve needles' on hemiplegia patients with 'qi deficiency and blood stasis' syndrome in the convalescent stage of Ischaemic stroke: study protocol for a randomised controlled trial. 61
33736678 2021
36
Mechanical thrombectomy for middle cerebral artery occlusion associated with ovarian hyperstimulation syndrome: case report and review of the literature. 61
33752418 2021
37
Scoliosis in Children Treated With Photon Craniospinal Irradiation for Medulloblastoma. 61
33516438 2021
38
A novel ATP1A2 variant associated with severe stepwise regression, hemiplegia, epilepsy and movement disorders in two unrelated patients. 61
33578253 2021
39
Novel presentations associated with a PDHA1 variant - Alternating hemiplegia in Hemizygote proband and Guillain Barre Syndrome in Heterozygote mother. 61
33592356 2021
40
A case of longitudinally extensive transverse myelitis in an 80-year-old patient with systemic lupus erythematous and anti-aquaporin 4 antibodies. 61
33812223 2021
41
The Combined Effect of Neuromuscular Electrical Stimulation and Insulin Therapy on Glycated Hemoglobin Concentrations, Lipid Profiles and Hemodynamic Parameters in Patients with Type-2-Diabetes and Hemiplegia Related to Ischemic Stroke: A Pilot Study. 61
33810235 2021
42
[Hypoglycemia]. 61
33762453 2021
43
Relation Between Reach Distance and Center of Pressure Distance for Multidirectional Reach in Hemiplegic Patients. 61
33774552 2021
44
The first case of traumatic internal carotid arterial dissection? Verneuil's case report from 1872. 61
32778340 2021
45
The gait is less stable in children with cerebral palsy in normal and dual-task gait compared to typically developed peers. 61
33493716 2021
46
Zhenbao pill attenuates hydrogen peroxide-induced apoptosis by inhibiting autophagy in human umbilical vein endothelial cells. 61
33716080 2021
47
Investigating psychometric properties of the arm activity measure - Thai version (ArmA-TH) sub-scales using the Rasch model. 61
33750313 2021
48
Pituitary tumor apoplexy associated with extrapontine myelinolysis during pregnancy: A case report. 61
33725898 2021
49
Stage-related implications of community-acquired pressure injuries for the acute medical inpatients. 61
33325127 2021
50
Comparing soleus injections and gastrocnemius injections of botulinum toxin for treating adult spastic foot drop: a monocentric observational study. 61
33784844 2021

Variations for Hemiplegia

ClinVar genetic disease variations for Hemiplegia:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ATP1A3 NM_152296.5(ATP1A3):c.2839G>A (p.Gly947Arg) SNV Pathogenic 37110 rs398122887 GRCh37: 19:42471896-42471896
GRCh38: 19:41967744-41967744
2 ATP1A3 NM_152296.5(ATP1A3):c.2443G>A (p.Glu815Lys) SNV Pathogenic 37108 rs387907281 GRCh37: 19:42474436-42474436
GRCh38: 19:41970284-41970284
3 ATP1A3 NM_152296.5(ATP1A3):c.958G>C (p.Ala320Pro) SNV Likely pathogenic 523558 rs879255368 GRCh37: 19:42489105-42489105
GRCh38: 19:41984953-41984953
4 DSP NM_004415.4(DSP):c.5218G>A (p.Glu1740Lys) SNV Uncertain significance 44926 rs142885240 GRCh37: 6:7581641-7581641
GRCh38: 6:7581408-7581408
5 SCN5A NM_000335.5(SCN5A):c.892G>A (p.Gly298Ser) SNV Uncertain significance 9387 rs137854608 GRCh37: 3:38651267-38651267
GRCh38: 3:38609776-38609776
6 MYH6 NM_002471.3(MYH6):c.4594C>T (p.Arg1532Cys) SNV Uncertain significance 239175 rs201827489 GRCh37: 14:23856794-23856794
GRCh38: 14:23387585-23387585
7 MYH6 NM_002471.4(MYH6):c.3195G>C (p.Gln1065His) SNV Uncertain significance 14149 rs267606904 GRCh37: 14:23862177-23862177
GRCh38: 14:23392968-23392968

Expression for Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for Hemiplegia

Pathways related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 12.62 SLC2A1 MMP9 COL4A2 COL4A1 ADCY5
2
Show member pathways
12.5 SLC1A3 SLC1A1 SCN1A CACNA1A ADCY5
3
Show member pathways
12.47 SLC1A1 MMP9 COL4A2 COL4A1 ATP1A3 ATP1A2
4
Show member pathways
12.36 TAC1 SCN1A ATP1A3 ATP1A2 ADCY5
5
Show member pathways
11.74 SLC1A3 SLC1A1 CACNA1A ATP1A2
6 11.63 SLC1A3 SLC1A1 SCN1A S100B ENO2 CALCA
7 11.59 MYH6 ATP1A3 ATP1A2
8 11.54 SLC2A1 MYH6 ATP1A3 ATP1A2
9 11.53 SLC2A1 SLC1A3 S100B
10 11.37 MMP9 COL4A2 COL4A1
11 11.21 SLC2A1 ATP1A3 ATP1A2 ADCY5

GO Terms for Hemiplegia

Cellular components related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.06 TAC1 S100B MMP9 ENO2 COL4A2 COL4A1
2 axon GO:0030424 9.72 TAC1 SLC1A1 SCN1A CALCA ATP1A3
3 photoreceptor inner segment GO:0001917 9.58 SLC2A1 ENO2 ATP1A3
4 presynapse GO:0098793 9.56 TBC1D24 SLC2A1 SLC1A1 CACNA1A
5 synapse GO:0045202 9.56 TBC1D24 TAC1 SLC2A1 SLC1A3 SLC1A1 CACNA1A
6 sodium:potassium-exchanging ATPase complex GO:0005890 9.43 ATP1A3 ATP1A2
7 collagen type IV trimer GO:0005587 9.37 COL4A2 COL4A1
8 intercalated disc GO:0014704 9.33 SLC2A1 SCN1A ATP1A2
9 neuronal cell body GO:0043025 9.28 TAC1 SLC1A3 SLC1A1 SCN1A ENO2 CALCA

Biological processes related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.93 SLC1A3 SLC1A1 SCN1A CACNA1A ATP1A3 ATP1A2
2 ion transmembrane transport GO:0034220 9.92 SCN1A CACNA1A ATP1A3 ATP1A2
3 chemical synaptic transmission GO:0007268 9.83 TAC1 SLC1A3 SLC1A1 CACNA1A
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.71 TAC1 CALCA CACNA1A ADCY5
5 cation transmembrane transport GO:0098655 9.67 SCN1A CACNA1A ATP1A2
6 L-glutamate transmembrane transport GO:0015813 9.61 SLC1A3 SLC1A1
7 response to amyloid-beta GO:1904645 9.61 MMP9 CACNA1A
8 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.6 ATP1A3 ATP1A2
9 sodium ion export across plasma membrane GO:0036376 9.59 ATP1A3 ATP1A2
10 cellular potassium ion homeostasis GO:0030007 9.58 ATP1A3 ATP1A2
11 cellular response to steroid hormone stimulus GO:0071383 9.58 ATP1A3 ATP1A2
12 neuromuscular process controlling posture GO:0050884 9.57 SCN1A PNKD
13 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.56 ATP1A3 ATP1A2
14 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.55 COL4A2 COL4A1
15 neurotransmitter uptake GO:0001504 9.54 SLC1A3 ATP1A2
16 transepithelial transport GO:0070633 9.51 SLC1A3 SLC1A1
17 L-glutamate import across plasma membrane GO:0098712 9.48 SLC1A3 SLC1A1
18 D-aspartate import across plasma membrane GO:0070779 9.43 SLC1A3 SLC1A1
19 response to glycoside GO:1903416 9.37 ATP1A3 ATP1A2
20 L-aspartate import across plasma membrane GO:0140009 9.32 SLC1A3 SLC1A1
21 neuron death in response to oxidative stress GO:0036475 9.26 TBC1D24 SLC1A1
22 L-glutamate import GO:0051938 9.16 SLC1A3 SLC1A1
23 cellular sodium ion homeostasis GO:0006883 9.13 SLC1A3 ATP1A3 ATP1A2
24 regulation of blood pressure GO:0008217 8.92 TAC1 MYH6 CALCA ATP1A2

Molecular functions related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.73 SLC1A3 SLC1A1 S100B RNF213 PNKD MMP9
2 L-glutamate transmembrane transporter activity GO:0005313 9.43 SLC1A3 SLC1A1
3 glutamate binding GO:0016595 9.4 SLC1A3 SLC1A1
4 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP1A3 ATP1A2
5 potassium-transporting ATPase activity GO:0008556 9.32 ATP1A3 ATP1A2
6 steroid hormone binding GO:1990239 9.26 ATP1A3 ATP1A2
7 high-affinity glutamate transmembrane transporter activity GO:0005314 9.16 SLC1A3 SLC1A1
8 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A3 SLC1A1

Sources for Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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