Aliases & Classifications for Hemiplegia

MalaCards integrated aliases for Hemiplegia:

Name: Hemiplegia 12 76 53 29 6 44 15
Postnatal Infantile Hemiplegia 12
Hemiplegia, Infantile 73
Infantile Hemiplegia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10969
ICD9CM 35 343.4
MeSH 44 D006429
SNOMED-CT 68 1593000
ICD10 33 G81 G81.9
UMLS 73 C0392550

Summaries for Hemiplegia

Disease Ontology : 12 A central nervous system disease that is characterized by the complete paralysis of half of the body.

MalaCards based summary : Hemiplegia, also known as postnatal infantile hemiplegia, is related to porencephaly 1 and alternating hemiplegia of childhood. An important gene associated with Hemiplegia is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are G-Beta Gamma Signaling and Aldosterone synthesis and secretion. The drugs Acetylcholine and Gastrodia have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Hemiparesis, or unilateral paresis, is weakness of one entire side of the body (hemi- means "half").... more...

Related Diseases for Hemiplegia

Diseases related to Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 porencephaly 1 32.9 COL4A1 COL4A2
2 alternating hemiplegia of childhood 32.8 ADCY5 ATP1A2 ATP1A3 CACNA1A CALCA SLC1A3
3 porencephaly 32.5 COL4A1 COL4A2
4 episodic ataxia 32.3 ATP1A2 CACNA1A SLC1A3
5 familial porencephaly 32.3 COL4A1 COL4A2
6 moyamoya disease 1 32.0 ACTA2 GUCY1A1 RNF213
7 episodic ataxia, type 6 31.7 CACNA1A SLC1A3
8 familial hemiplegic migraine 31.5 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A
9 hemiplegic migraine 31.3 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A SLC2A1
10 epilepsy 30.5 ATP1A2 ATP1A3 CACNA1A SCN1A SLC2A1
11 headache 29.7 ATP1A2 CACNA1A SCN1A TAC1
12 spastic hemiplegia 12.6
13 alternating hemiplegia of childhood 2 12.4
14 alternating hemiplegia of childhood 1 12.4
15 idiopathic hemiconvulsion-hemiplegia syndrome 12.3
16 hemiplegia alterans 12.3
17 benign nocturnal alternating hemiplegia of childhood 12.1
18 epileptic hemiplegia 12.1
19 weber syndrome 11.4
20 medial medullary syndrome 11.2
21 porencephaly 2 11.1
22 brown-sequard syndrome 11.1
23 sulfite oxidase deficiency, isolated 10.9
24 moyamoya disease 2 10.9
25 moyamoya disease 5 10.9
26 moyamoya disease 6 with or without achalasia 10.9
27 childhood-onset cerebral x-linked adrenoleukodystrophy 10.9
28 spastic cerebral palsy 10.9
29 anosognosia 10.6
30 herpes zoster 10.2
31 herpes zoster ophthalmicus 10.2
32 spasticity 10.2
33 angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 10.2 COL4A1 COL4A2
34 cerebral palsy 10.2
35 dystonia 10.1
36 oculogyric crisis 10.1 ATP1A3 SLC2A1
37 reflex sympathetic dystrophy 10.1
38 brain injury 10.1
39 algoneurodystrophy 10.1
40 aphasia 10.1
41 sporadic hemiplegic migraine 10.1 ATP1A2 CACNA1A SCN1A
42 familial or sporadic hemiplegic migraine 10.1 ATP1A2 CACNA1A SCN1A
43 aceruloplasminemia 10.1 ATP1A3 CACNA1A SLC2A1
44 migraine without aura 10.1 ATP1A2 CACNA1A SCN1A
45 cluster headache 10.0 CACNA1A CALCA
46 cerebral arterial disease 10.0 ACTA2 GUCY1A1 RNF213
47 migraine with aura 10.0 ATP1A2 CACNA1A SCN1A
48 stroke, ischemic 10.0
49 quadriplegia 10.0
50 encephalitis 10.0

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to Hemiplegia

Symptoms & Phenotypes for Hemiplegia

UMLS symptoms related to Hemiplegia:


hemiplegia

MGI Mouse Phenotypes related to Hemiplegia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 ADCY5 ATP1A2 ATP1A3 CACNA1A COL4A1 RNF213
2 homeostasis/metabolism MP:0005376 9.96 ADCY5 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2
3 cardiovascular system MP:0005385 9.92 ACTA2 ATP1A2 COL4A1 COL4A2 GUCY1A1 RNF213
4 muscle MP:0005369 9.7 ACTA2 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2
5 nervous system MP:0003631 9.61 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 GUCY1A1
6 respiratory system MP:0005388 9.17 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 GUCY1A1

Drugs & Therapeutics for Hemiplegia

Drugs for Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Not Applicable 51-84-3 187
2 Gastrodia Phase 4
3 Cholinergic Agents Phase 4,Phase 3,Not Applicable
4 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Not Applicable
6 abobotulinumtoxinA Phase 4,Phase 3,Not Applicable
7 Botulinum Toxins, Type A Phase 4,Phase 3,Not Applicable
8 Acetylcholine Release Inhibitors Phase 4,Phase 3,Not Applicable
9 onabotulinumtoxinA Phase 4,Phase 3,Not Applicable
10 Neuromuscular Agents Phase 4,Phase 3
11 Botulinum Toxins Phase 4,Phase 3,Not Applicable
12 incobotulinumtoxinA Phase 4,Not Applicable
13
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
14
Ticagrelor Approved Phase 3 274693-27-5 9871419
15
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
16
Ticlopidine Approved Phase 3 55142-85-3 5472
17 tannic acid Approved Phase 3,Not Applicable
18
Benzocaine Approved, Investigational Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
19 Analgesics Phase 3,Not Applicable
20 Anti-Inflammatory Agents, Non-Steroidal Phase 3
21 Purinergic P2 Receptor Antagonists Phase 3
22 Cyclooxygenase Inhibitors Phase 3
23 Analgesics, Non-Narcotic Phase 3
24 Antirheumatic Agents Phase 3
25 Purinergic P2Y Receptor Antagonists Phase 3
26 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
27 Antipyretics Phase 3
28 Platelet Aggregation Inhibitors Phase 3
29 Cytochrome P-450 CYP2C19 Inhibitors Phase 3,Phase 2
30 Fibrinolytic Agents Phase 3
31 lysine Phase 3
32 Acetylsalicylic acid lysinate Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Not Applicable
34
Sodium oxybate Approved Phase 1, Phase 2 502-85-2 5360545
35
Lidocaine Approved, Vet_approved Phase 2,Not Applicable 137-58-6 3676
36
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
37
Hydrocortisone acetate Approved, Vet_approved Phase 1, Phase 2 50-03-3
38
Hydrocortisone Approved, Vet_approved Phase 1, Phase 2 50-23-7 5754
39
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
40
Tamoxifen Approved Phase 2 10540-29-1 2733526
41
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
42
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
43
Glycerol Approved, Investigational Phase 2 56-81-5 753
44
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 1, Phase 2,Phase 2 59-43-8, 70-16-6 1130
45
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
46
Vitamin C Approved, Nutraceutical Phase 1, Phase 2,Phase 2 50-81-7 5785 54670067
47 Carbon fiber Phase 1, Phase 2
48 Anesthetics Phase 1, Phase 2,Phase 2,Not Applicable
49 Central Nervous System Depressants Phase 1, Phase 2,Phase 2,Not Applicable
50 Anesthetics, General Phase 1, Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 271)
# Name Status NCT ID Phase Drugs
1 Functional Electrical Stimulation (FES) Assisted Walking: Enhancement of Walking Function After Stroke Unknown status NCT00552916 Phase 4
2 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
3 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
4 The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy Unknown status NCT01256021 Phase 4 Botulinum Toxin Type A
5 Τhe Effectiveness of Hydrotherapy Exercises on the Rehabilitation of Hemiplegic Patients Completed NCT01460277 Phase 4
6 Spread And Effectiveness Of Botulinum Neurotoxin A In Spastic Equinus In Cerebral Palsy Completed NCT01276015 Phase 4 Botulinum Toxin Type A
7 Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC) Completed NCT02969356 Phase 4 AbobotulinumtoxinA (Dysport®)
8 Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression Completed NCT02321436 Phase 4 BotulinumtoxinA;Placebo
9 The Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Recruiting NCT02944929 Phase 4
10 Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing Dynamic Hand Splinting in Adults With Post-stroke Hemiplegia (Orthox) Not yet recruiting NCT02888548 Phase 4
11 HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
12 Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) Unknown status NCT02817789 Phase 3 Ticagrelor alone;Combination lysine acetylsalicylate - clopidogrel
13 Mental Practice Efficacy in Stroke-Induced Hemiparesis Unknown status NCT01026896 Phase 2, Phase 3
14 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
15 MEOPA to Improve Physical Therapy Results After Multilevel Surgery Completed NCT00632528 Phase 3 MEOPA;Medicinal air
16 Assisted Movement Neuro-rehabilitation: VA Multi-site Clinical Trial Completed NCT00223808 Phase 3
17 Static and Dynamic Postural Stability in Cerebral Palsy Children Completed NCT01799304 Phase 3
18 Ventilatory Muscle Training in Stroke Completed NCT02828943 Phase 3
19 Phase III Clinical Trial of "Botulax®" to Treat Children With Cerebral Palsy Completed NCT01787344 Phase 3 Botulinum Toxin Type A(Botox®);Botulinum toxin type A(Botulax®)
20 Home Based Adaptive Arm Training for Children Recruiting NCT02751502 Phase 3
21 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
22 iMRI Guided Resection in Cerebral Glioma Surgery Recruiting NCT01479686 Phase 3
23 Burke-Hocoma Efficiency Study Enrolling by invitation NCT03555825 Phase 3
24 Effects of the Quantity of Repetitive Transcranial Magnetic Stimulation(rTMS) on the Recovery After Stroke Terminated NCT01311271 Phase 2, Phase 3
25 Bimanual Training in Children With Hemiplegia Unknown status NCT01413594 Phase 1, Phase 2
26 Bimanual Training in Children With Hemiplegia With Lower Limb and Postural Stimulation (HABIT & Leg) Unknown status NCT01700777 Phase 1, Phase 2
27 Passive Mobilisation of Region of Shoulder Joints for Hemiplegic Patient Unknown status NCT02904148 Phase 2
28 Rehabilitation of Early Stroke Patients Using an AFO: an RCT Unknown status NCT01006772 Phase 1, Phase 2
29 Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction Unknown status NCT01010607 Phase 1, Phase 2
30 The Middle East "Stepping Forward" Project (MESF) Unknown status NCT01466296 Phase 2
31 mCIMT and Eye Patching for Neglect Rehabilitation Post Stroke: A Longitudinal Study of Separate and Combined Effects Unknown status NCT00253825 Phase 1, Phase 2
32 Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO) Completed NCT00931164 Phase 1, Phase 2 Sodium Oxybate
33 Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
34 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity of Hemiplegics Completed NCT01569386 Phase 2
35 Training the Arm and Hand After Stroke Using Auditory Rhythm Cues Completed NCT00523523 Phase 1, Phase 2
36 Post Stroke Hand Functions: Bilateral Movements and Electrical Stimulation Treatments Completed NCT00369668 Phase 2
37 Contrastim Stroke Trial Completed NCT01049802 Phase 1, Phase 2
38 Treatments for Recovery of Hand Function in Acute Stroke Survivors Completed NCT00565045 Phase 1, Phase 2
39 FNS and Weight Support Treadmill Training for Gait Component Restoration Completed NCT00011596 Phase 2
40 The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy Completed NCT00619853 Phase 2
41 SSNB in Hemiplegic Shoulder Pain Completed NCT00732589 Phase 2 1% xylocaine
42 Robot Assisted Upper Limb Neuro-Rehabilitation Completed NCT00011583 Phase 2
43 A Trial Comparing Two Methods of CIMT in the Hemiplegic Child Completed NCT01770678 Phase 2
44 Subacromial Corticosteroid Injection for Hemiplegic Shoulder Pain Completed NCT00597766 Phase 2 Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine
45 Video-Based Functional Performance and Assessment Following Stroke Completed NCT00013494 Phase 2
46 Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study Completed NCT00810095 Phase 2
47 Safety Escalating Repeat IV, in Stroke Patients Completed NCT00833989 Phase 2 GSK249320;PLACEBO
48 Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock Recruiting NCT03649633 Phase 1, Phase 2 Stress-dose Hydrocortisone plus Vitamin C;isotonic sodium chloride solution placebo plus isotonic sodium chloride solution placebo
49 Treatment With Tamoxifen in Cryptococcal Meningitis Recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
50 Pilot Study, Comparative, Single-center, Randomized, Crossover, Double-blind, Against Placebo, Testing the Effectiveness of Triheptanoin Oil in Alternating Hemiplegia of Childhood Active, not recruiting NCT02408354 Phase 2 Triheptanoin;Placebo

Search NIH Clinical Center for Hemiplegia

Cochrane evidence based reviews: hemiplegia

Genetic Tests for Hemiplegia

Genetic tests related to Hemiplegia:

# Genetic test Affiliating Genes
1 Hemiplegia 29

Anatomical Context for Hemiplegia

MalaCards organs/tissues related to Hemiplegia:

41
Brain, Bone, Testes, Cortex, Spinal Cord, Heart, Kidney

Publications for Hemiplegia

Articles related to Hemiplegia:

(show top 50) (show all 1132)
# Title Authors Year
1
Feasibility of Synergy-Based Exoskeleton Robot Control in Hemiplegia. ( 29877848 )
2018
2
Robotically-driven orthoses exert proximal-to-distal differential recovery on the lower limbs in children with hemiplegia, early after acquired brain injury. ( 29650492 )
2018
3
Clinical aspects, neuroimaging, and electroencephalography of 35 cases of hemiconvulsion-hemiplegia syndrome. ( 29414550 )
2018
4
Hemiconvulsion Hemiplegia Syndrome in a young boy with developmental delay. ( 29808062 )
2018
5
Dynamic Analysis of the Abnormal Isometric Strength Movement Pattern between Shoulder and Elbow Joint in Patients with Hemiplegia. ( 29610654 )
2018
6
Hemiplegia and bilateral globus pallidus infarcts after carbon monoxide poisoning: case report. ( 29571238 )
2018
7
Atrial myxoma with hemiplegia. ( 29474708 )
2018
8
A Seizure and Hemiplegia following Contrast Exposure: Understanding Contrast-Induced Encephalopathy. ( 29686712 )
2018
9
An episode of acute encephalopathy with biphasic seizures and late reduced diffusion followed by hemiplegia and intractable epilepsy observed in a patient with a novel frameshift mutation in HNRNPU. ( 29858110 )
2018
10
Effects of gait training with non-paretic knee immobilization on patients with hemiplegia: Three single-case studies. ( 29469599 )
2018
11
Long-term follow up of an adult with alternating hemiplegia of childhood and a p.Gly755Ser mutation in the ATP1A3 gene. ( 29269014 )
2018
12
Hemiconvulsion-hemiplegia-epilepsy evolving to contralateral hemi-Lennox-Gastaut-like phenotype. ( 29459061 )
2018
13
Development of an item list to assess bilateral upper extremity function of stroke patients with hemiplegia. ( 29400669 )
2018
14
Structural analysis of a rehabilitative training system based on a ceiling rail for safety of hemiplegia patients. ( 29710754 )
2018
15
Pial arteriovenous fistula of the spine in a child with hemiplegia. ( 29881582 )
2018
16
Different impact of prism adaptation rehabilitation in spatial neglect and anosognosia for hemiplegia. ( 29357315 )
2018
17
A walk after hemiplegia. ( 29589055 )
2018
18
Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood. ( 29567111 )
2018
19
Kinesiophobia after complex regional pain syndrome type one in a case of stroke hemiplegia and effect of cognitive behavior therapy. ( 29736085 )
2018
20
Pearls & Oy-sters: Alternating hemiplegia of childhood mimics focal epilepsy and paroxysmal dyskinesia in infancy. ( 29967203 )
2018
21
Rewiring to Regain Function in Patients with Spastic Hemiplegia. ( 29261362 )
2018
22
The effect and biomechanical mechanisms of intradermal needle for post-stroke hemiplegia recovery: Study protocol for a randomized controlled pilot trial. ( 29668611 )
2018
23
Novel E815K knock-in mouse model of alternating hemiplegia of childhood. ( 30071271 )
2018
24
Benign nocturnal alternating hemiplegia of childhood: A clinical and nomenclatural reappraisal. ( 30194039 )
2018
25
Cognitive, adaptive, and behavioral profiles and management of alternating hemiplegia of childhood. ( 30362107 )
2018
26
Alternating hemiplegia of childhood: the gap between paroxysmal manifestations and non-paroxysmal characteristics. ( 30548852 )
2018
27
Understanding Anosognosia for Hemiplegia After Stroke. ( 30086101 )
2018
28
Hemiconvulsion-Hemiplegia-Epilepsy in a girl with cobalamin C deficiency. ( 30530444 )
2018
29
Effectiveness of Neuromuscular Electrical Stimulation on Lower Limbs of Patients With Hemiplegia After Chronic Stroke: A Systematic Review. ( 29357280 )
2018
30
The Timed 180° Turn Test for Assessing People with Hemiplegia from Chronic Stroke. ( 29568774 )
2018
31
Acute Onset of Unilateral Edema of Leg Followed by Hemiplegia in an Adolescent: A Case Report. ( 30008250 )
2018
32
Preliminary evaluation of the reliability, validity and feasibility of the arm activity measure - Thai version (ArmA-TH) in cerebrovascular patients with upper limb hemiplegia. ( 30012165 )
2018
33
Effects of water-based and land-based exercises on walking and balance functions of patients with hemiplegia. ( 30040763 )
2018
34
Effects of MOTOmed movement therapy on the mobility and activities of daily living of stroke patients with hemiplegia: a systematic review and meta-analysis. ( 30088421 )
2018
35
Proptosis and hemiplegia as an initial manifestation of multiple myeloma. ( 30117481 )
2018
36
Anterior-posterior displacement of center of pressure measured by insole foot pressure measurement system in subacute recovery stage of post-stroke hemiplegia. ( 30124457 )
2018
37
Gait training using a stationary, one-leg gait exercise assist robot for chronic stroke hemiplegia: a case report. ( 30154598 )
2018
38
Quantitative assessment of knee extensor thrust, flexed-knee gait, insufficient knee flexion during the swing phase, and medial whip in hemiplegia using three-dimensional treadmill gait analysis. ( 30209977 )
2018
39
Assessment of the Efficacy of ReoGo-J Robotic Training Against Other Rehabilitation Therapies for Upper-Limb Hemiplegia After Stroke: Protocol for a Randomized Controlled Trial. ( 30210446 )
2018
40
Effect of crossed-education using a tilt table task-oriented approach in subjects with post-stroke hemiplegia: A randomized controlled trial. ( 30221305 )
2018
41
The Impact of Whole Body Vibration Therapy on Spasticity and Disability of the Patients with Poststroke Hemiplegia. ( 30225145 )
2018
42
Bilateral persistent primitive hypoglossal artery presenting with hemiplegia✰. ( 30228846 )
2018
43
Acute Hemiplegia in Children: A Prospective Study of Etiology, Clinical Presentation, and Outcome from Western India. ( 30271041 )
2018
44
Effects of diaphragm and deep abdominal muscle exercise on walking and balance ability in patients with hemiplegia due to stroke. ( 30276188 )
2018
45
Proptosis with hemiplegia: Unusual presentation of multiple myeloma. ( 30306967 )
2018
46
Effect of Stride Management Assist Gait Training for Poststroke Hemiplegia: A Single Center, Open-Label, Randomized Controlled Trial. ( 30420315 )
2018
47
Development of a Method to Quantify Abnormal Kinetic and Kinematic Coupling Patterns during Functional Movements in the Paretic Arm and Hand of Individuals with Pediatric Hemiplegia. ( 30440861 )
2018
48
Functional Gains in Children With Spastic Hemiplegia Following a Tendon Achilles Lengthening Using Computerized Adaptive Testing-A Pilot Study. ( 30456216 )
2018
49
Effect of sensory and motor connectivity on hand function in pediatric hemiplegia. ( 29034483 )
2017
50
REACH: study protocol of a randomised trial of rehabilitation very early in congenital hemiplegia. ( 28928195 )
2017

Variations for Hemiplegia

ClinVar genetic disease variations for Hemiplegia:

6 (show all 15)
# Gene Variation Type Significance SNP ID Assembly Location
1 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 GRCh37 Chromosome 14, 23862177: 23862177
2 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 GRCh38 Chromosome 14, 23392968: 23392968
3 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 NCBI36 Chromosome 14, 22932017: 22932017
4 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh37 Chromosome 19, 42474436: 42474436
5 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh38 Chromosome 3, 38609776: 38609776
6 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh37 Chromosome 3, 38651267: 38651267
7 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh37 Chromosome 19, 42489105: 42489105
8 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh38 Chromosome 19, 41984953: 41984953
9 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh38 Chromosome 14, 23387585: 23387585
10 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh37 Chromosome 14, 23856794: 23856794
11 DSP NM_004415.3(DSP): c.5218G> A (p.Glu1740Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs142885240 GRCh38 Chromosome 6, 7581408: 7581408
12 DSP NM_004415.3(DSP): c.5218G> A (p.Glu1740Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs142885240 GRCh37 Chromosome 6, 7581641: 7581641
13 ATP1A3 NM_152296.4(ATP1A3): c.2839G> A (p.Gly947Arg) single nucleotide variant Pathogenic rs398122887 GRCh38 Chromosome 19, 41967744: 41967744
14 ATP1A3 NM_152296.4(ATP1A3): c.2839G> A (p.Gly947Arg) single nucleotide variant Pathogenic rs398122887 GRCh37 Chromosome 19, 42471896: 42471896
15 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh38 Chromosome 19, 41970284: 41970284

Expression for Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for Hemiplegia

Pathways related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 ACTA2 ADCY5 CACNA1A GUCY1A1 SCN1A
2
Show member pathways
12.5 ADCY5 ATP1A2 ATP1A3 SLC2A1
3
Show member pathways
12.41 ACTA2 ADCY5 ATP1A2 ATP1A3 GUCY1A1
4
Show member pathways
12.14 ACTA2 ADCY5 CACNA1A CALCA GUCY1A1
5
Show member pathways
12.1 ACTA2 ADCY5 CACNA1A COL4A1 COL4A2 GUCY1A1
6
Show member pathways
12.02 ACTA2 ADCY5 ATP1A2 ATP1A3 SCN1A TAC1
7 11.9 ATP1A3 SLC1A3 TAC1
8
Show member pathways
11.84 ADCY5 ATP1A2 ATP1A3 GUCY1A1
9 11.7 ATP1A2 ATP1A3 SLC2A1
10
Show member pathways
11.67 ATP1A2 CACNA1A SLC1A3
11 11.56 ADCY5 ATP1A2 ATP1A3
12 11.31 ADCY5 ATP1A2 ATP1A3 SLC2A1
13 10.86 ATP1A2 ATP1A3

GO Terms for Hemiplegia

Cellular components related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.62 ATP1A3 CALCA SCN1A TAC1
2 sodium:potassium-exchanging ATPase complex GO:0005890 9.26 ATP1A2 ATP1A3
3 collagen type IV trimer GO:0005587 9.16 COL4A1 COL4A2
4 intercalated disc GO:0014704 9.13 ATP1A2 SCN1A SLC2A1
5 neuronal cell body GO:0043025 9.1 ATP1A3 CACNA1A CALCA SCN1A SLC1A3 TAC1

Biological processes related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.89 ATP1A2 ATP1A3 CACNA1A SCN1A SLC1A3
2 aging GO:0007568 9.75 BGLAP CALCA COL4A2
3 sodium ion transport GO:0006814 9.73 ATP1A2 ATP1A3 SCN1A
4 adult walking behavior GO:0007628 9.59 CACNA1A SCN1A
5 cellular response to amyloid-beta GO:1904646 9.58 ATP1A3 CACNA1A
6 ATP hydrolysis coupled proton transport GO:0015991 9.57 ATP1A2 ATP1A3
7 cyclic nucleotide biosynthetic process GO:0009190 9.55 ADCY5 GUCY1A1
8 cellular sodium ion homeostasis GO:0006883 9.54 ATP1A2 ATP1A3
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.52 ATP1A2 ATP1A3
10 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.51 ATP1A2 ATP1A3
11 neuromuscular process controlling balance GO:0050885 9.5 ADCY5 CACNA1A SLC1A3
12 cellular potassium ion homeostasis GO:0030007 9.48 ATP1A2 ATP1A3
13 cellular response to steroid hormone stimulus GO:0071383 9.46 ATP1A2 ATP1A3
14 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 ADCY5 CACNA1A CALCA TAC1
15 sodium ion export across plasma membrane GO:0036376 9.43 ATP1A2 ATP1A3
16 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.4 COL4A1 COL4A2
17 neurotransmitter uptake GO:0001504 9.37 ATP1A2 SLC1A3
18 response to glycoside GO:1903416 9.26 ATP1A2 ATP1A3
19 response to pain GO:0048265 9.13 CACNA1A CALCA TAC1
20 regulation of blood pressure GO:0008217 9.02 ACTA2 ATP1A2 CALCA GUCY1A1 TAC1

Molecular functions related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorus-oxygen lyase activity GO:0016849 9.16 ADCY5 GUCY1A1
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP1A2 ATP1A3
3 steroid hormone binding GO:1990239 8.62 ATP1A2 ATP1A3

Sources for Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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