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Aliases & Classifications for Hemiplegia

MalaCards integrated aliases for Hemiplegia:

Name: Hemiplegia 11 75 5 43 14 16 75 31
Postnatal Infantile Hemiplegia 11
Hemiplegia, Infantile 71
Infantile Hemiplegia 11


External Ids:

Disease Ontology 11 DOID:10969
ICD9CM 34 343.4
MeSH 43 D006429
SNOMED-CT 68 155024003
ICD10 31 G81 G81.9
UMLS 71 C0392550

Summaries for Hemiplegia

Disease Ontology: 11 A central nervous system disease that is characterized by the complete paralysis of half of the body.

MalaCards based summary: Hemiplegia, also known as postnatal infantile hemiplegia, is related to spastic hemiplegia and familial porencephaly. An important gene associated with Hemiplegia is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are Signal Transduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Baclofen and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: 75 Hemiparesis, or unilateral paresis, is weakness of one entire side of the body (hemi- means "half").... more...

Related Diseases for Hemiplegia

Diseases related to Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 711)
# Related Disease Score Top Affiliating Genes
1 spastic hemiplegia 33.0 COL4A2 COL4A1
2 familial porencephaly 32.5 COL4A2 COL4A1
3 alternating hemiplegia of childhood 32.4 TAC1 SLC2A1 SLC1A3 SCN1A RHOBTB2 PDHA1
4 episodic ataxia, type 6 32.0 SLC1A3 SLC1A1 CACNA1A
5 episodic ataxia 31.6 SLC2A1 SLC1A3 SCN1A PDHA1 CACNA1A ATP1A3
6 familial hemiplegic migraine 31.5 SLC1A3 SCN1A CALCA CACNA1A ATP1A3 ATP1A2
7 cerebral palsy 31.2 S100B COL4A2 COL4A1 CACNA1A BGLAP
8 status epilepticus 31.0 SCN1A S100B ENO2 CACNA1A
9 dystonia 12 31.0 CACNA1A ATP1A3 ATP1A2
10 movement disease 30.9 SLC2A1 CACNA1A ATP1A3 ADCY5
11 dystonia 30.7 SLC2A1 RHOBTB2 PDHA1 CACNA1A ATP1A3 ADCY5
12 epilepsy 30.7 SLC2A1 SLC1A3 SLC1A1 SCN1A S100B CACNA1A
13 headache 30.7 SCN1A CALCA CACNA1A ATP1A2
14 meningitis 30.4 S100B MMP9 ENO2 CALCA
15 lateral medullary syndrome 30.3 TAC1 CALCA
16 reflex sympathetic dystrophy 30.3 TAC1 CALCA
17 early infantile epileptic encephalopathy 30.2 SLC2A1 SCN1A CACNA1A ATP1A3 ATP1A2
18 horner's syndrome 30.2 ENO2 CALCA
19 early myoclonic encephalopathy 30.1 SLC2A1 SCN1A CACNA1A
20 migraine, familial hemiplegic, 1 30.1 SLC1A3 SCN1A CACNA1A ATP1A2
21 pyruvate dehydrogenase e1-alpha deficiency 30.1 SLC2A1 SCN1A PDHA1
22 paine syndrome 30.1 TAC1 SCN1A CALCA
23 choreatic disease 30.1 TAC1 SLC2A1 RHOBTB2 CACNA1A ATP1A3 ADCY5
24 dravet syndrome 30.1 SLC2A1 SCN1A CACNA1A ATP1A2
25 meningioma, familial 30.0 SLC2A1 S100B MMP9 ENO2 COL4A1
26 migraine, familial hemiplegic, 2 30.0 SLC1A3 SCN1A CACNA1A ATP1A3 ATP1A2
27 focal dystonia 29.9 TAC1 CACNA1A ATP1A3
28 hepatic encephalopathy 29.9 SLC1A1 S100B MMP9
29 migraine with or without aura 1 29.9 TAC1 SLC1A3 SCN1A S100B MMP9 EDN1
30 akinetic mutism 29.9 S100B ENO2
31 lennox-gastaut syndrome 29.9 SLC2A1 SCN1A CACNA1A
32 brain small vessel disease 1 29.9 COL4A2 COL4A1 CACNA1A ATP1A2
33 autonomic nervous system disease 29.9 TAC1 SCN1A CALCA
34 episodic ataxia, type 2 29.9 SLC1A3 SCN1A CACNA1A ATP1A2
35 benign epilepsy with centrotemporal spikes 29.8 SLC2A1 SCN1A CACNA1A ATP1A2
36 gastroenteritis 29.7 SCN1A MMP9 CALCA
37 patent foramen ovale 29.7 SCN1A EDN1 COL4A1 CALCA CACNA1A ATP1A2
38 sleep apnea 29.7 TAC1 MMP9 EDN1
39 achalasia 29.7 S100B MMP9 ENO2
40 hemangioma 29.6 SLC2A1 MMP9 ENO2 CALCA
41 epilepsy, myoclonic juvenile 29.6 SLC2A1 SCN1A CACNA1A
42 migraine with aura 29.6 TAC1 SLC2A1 SLC1A3 SCN1A EDN1 CALCA
43 tetralogy of fallot 29.6 MMP9 ENO2 EDN1 CALCA
44 bronchitis 29.5 TAC1 MMP9 CALCA
45 peripheral nervous system disease 29.1 TAC1 SLC2A1 S100B MMP9 ENO2 EDN1
46 alternating hemiplegia of childhood 2 11.5
47 alternating hemiplegia of childhood 1 11.5
48 idiopathic hemiconvulsion-hemiplegia syndrome 11.4
49 spastic cerebral palsy 11.4
50 brain small vessel disease 1 with or without ocular anomalies 11.4

Graphical network of the top 20 diseases related to Hemiplegia:

Diseases related to Hemiplegia

Symptoms & Phenotypes for Hemiplegia

UMLS symptoms related to Hemiplegia:


GenomeRNAi Phenotypes related to Hemiplegia according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.21 ADCY5 ATP1A2 ATP1A3 BGLAP CACNA1A CALCA
2 no effect GR00402-S-2 10.21 ADCY5 ATP1A2 ATP1A3 BGLAP CACNA1A CALCA

MGI Mouse Phenotypes related to Hemiplegia:

# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.17 ATP1A2 ATP1A3 CACNA1A CALCA COL4A1 COL4A2
2 homeostasis/metabolism MP:0005376 10.06 ADCY5 ATP1A2 ATP1A3 BGLAP CACNA1A CALCA
3 muscle MP:0005369 9.86 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 EDN1
4 behavior/neurological MP:0005386 9.83 ADCY5 ATP1A2 ATP1A3 CACNA1A CALCA COL4A1
5 respiratory system MP:0005388 9.28 ATP1A2 ATP1A3 CACNA1A CALCA COL4A1 COL4A2

Drugs & Therapeutics for Hemiplegia

Drugs for Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Baclofen Approved Phase 4 1134-47-0 2284
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
5 GABA Agonists Phase 4
6 Pharmaceutical Solutions Phase 4
7 Betamethasone-17,21-dipropionate Phase 4
Betamethasone Valerate Phase 4 2152-44-5
Betamethasone sodium phosphate Phase 4
Betamethasone benzoate Phase 4
abobotulinumtoxinA Phase 4
12 Botulinum Toxins, Type A Phase 4
13 Botulinum Toxins Phase 4
14 Cholinergic Agents Phase 4
Sodium oxybate Approved Phase 1, Phase 2 502-85-2 23663870
Glycerin Approved, Investigational Phase 2 56-81-5 753
17 Carbon Fiber Phase 1, Phase 2
18 Anesthetics, Intravenous Phase 1, Phase 2
19 Anesthetics, General Phase 1, Phase 2
20 Protective Agents Phase 2
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
Tannic acid Approved 1401-55-4 16129878 16129778
23 Raspberry Approved
Frovatriptan Approved, Investigational 158747-02-5 77992
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
Sodium citrate Approved, Investigational 68-04-2 23431961
Ethanol Approved 64-17-5 702
Ropivacaine Approved 84057-95-4 71273 175805
Flumazenil Approved 78755-81-4 3373
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
33 Serotonin Receptor Agonists
34 Anti-Arrhythmia Agents
35 Sodium Channel Blockers
36 Diuretics, Potassium Sparing
37 Citrate
39 Antioxidants
40 Anesthetics
41 Anesthetics, Local
42 Neurotransmitter Agents
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show top 50) (show all 223)
# Name Status NCT ID Phase Drugs
1 Functional Electrical Stimulation (FES)-Assisted Walking: Enhancement of Voluntary Walking Function Among Persons With Severe Hemiplegia Post-Stroke Unknown status NCT00552916 Phase 4
2 Doctor, Physical Medicine and Rehabilitation Completed NCT03860662 Phase 4 Botox;Baclofen
3 Comparison of the Efficacy of Ultrasound Guided vs Non-guided Suprascapular Nerve Block Treatment in Stroke Patients With Hemiplegic Shoulder Pain. Recruiting NCT05260125 Phase 4 Ultrasound-guided Suprascapular Nerve Block;Anatomical Landmark-guided Suprascapular Nerve Block
4 Comparison of the Efficacy of 2 Different Botulinum Toxin Injection Techniques in Gastrocnemius Muscle Spasticity in Hemiplegic Patients: A Randomized Double-blind Controlled Study. Not yet recruiting NCT05615987 Phase 4 Onabotulinumtoxina for Injection
5 Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
6 Randomised Controlled Trial to Evaluate the Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity (Repeated Botulinum Toxin Injections and Physiotherapy) on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Unknown status NCT02944929 Phase 3
7 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
8 Burke-Hocoma Efficiency Study Completed NCT03555825 Phase 3
9 Assisted Movement Neuro-rehabilitation: VA Multi-site Clinical Trial Completed NCT00223808 Phase 3
10 Is it Possible to Improve Static and Dynamic Postural Stability in Cerebral Palsy Children by Modulating Attention? Completed NCT01799304 Phase 3
11 Effects of the Quantity of Repetitive Transcranial Magnetic Stimulation on the Recovery of Upper Motor Function After Stroke: a Randomized Controlled Trial Terminated NCT01311271 Phase 2, Phase 3
12 Effet de la réadaptation Sur Les déficiences, Limitations d'activité et Restriction de la Participation Des Enfants présentant Des lésions Neurologiques Non-évolutives (Infirmes Moteurs cérébraux). Unknown status NCT01700777 Phase 1, Phase 2
13 Rehabilitation of Early Stroke Patients Using a Custom-made Solid Ankle-foot Orthosis: a Randomised Controlled Trial Unknown status NCT01006772 Phase 1, Phase 2
14 Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction After Stroke Unknown status NCT01010607 Phase 1, Phase 2
15 A Phase 2 Study of HC-58 in Patients With Severe Upper Limb Hemiplegia After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
16 Single-center Phase I/II Trial of Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO Trial) Completed NCT00931164 Phase 1, Phase 2 Sodium Oxybate
17 Auditory Rhythm Cues + Task Practice: Effects on UE Motor Function Post-stroke Completed NCT00523523 Phase 1, Phase 2
18 Subacute Stroke Recovery (Upper Extremity Motor Function): Bimanual Coordination Training Completed NCT00369668 Phase 2
19 Contralaterally Controlled Functional Electrical Stimulation for Hemiparetic Hand Completed NCT00565045 Phase 1, Phase 2
20 "Etude Pilote, Comparative, Monocentrique, randomisée, en Cross Over, en Double Aveugle, Contre Placebo, Testant l'efficacité de l'Huile triheptanoïne Dans Les Hémiplégies Alternantes de l'Enfant" HEMIHEP Completed NCT02408354 Phase 2 Triheptanoin;Placebo
21 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity in the Affected Leg of Hemiplegics Completed NCT01569386 Phase 2
22 Pediatric Hemiplegia: Synergistic Treatment Using rTMS and CIT Completed NCT01104064 Phase 1
23 Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments Completed NCT01072461 Phase 1
24 Different Dilutions and Efficacy of Botulin Toxin in the Correction of the Hemiplegic Gait Recruiting NCT04630873 Phase 1 Botulinum toxin
25 Efficacy of Transcranial Laser Therapy for Improving Upper Extremity Functional Recovery in Hemiplegic Patients From Ischemic Stroke Terminated NCT01308216 Phase 1
26 National Egyptian Network Pediatric Stroke and Hemiplegia Registry Unknown status NCT02129491
27 Short-Term Effects of Whole-Body Vibration on Upper Extremity Function in Subjects With Poststroke Hemiplegia Unknown status NCT03963258
28 The Effects of Proximal And Distal Tibiofibular Joint Manipulations on Foot Posture, Ankle Range of Motion, and Balance in Chronic Hemiplegic Individuals Unknown status NCT04178369
29 Effects of Infant Constraint Induced Movement Therapy and Infant Bimanual Intensive Therapy in Unilateral Cerebral Palsy. A Randomized Controlled Trial. Unknown status NCT04642872
30 Neuromuscular Electrical Stimulation (NMES) Applied to Back Extensors in Stroke Patients; Effects on Functional Capacity and Mobility Unknown status NCT03811106
31 Early Effects of Trunk Kinesio Taping on Balance and Functional Performance in Patients With Acute Stroke Unknown status NCT04105322
32 Reliability of Rehabilitative Ultrasound Imaging for the Quadriceps Muscle and Sarcopenia in Poststroke Patients Unknown status NCT04042818
33 Morbidity Prevalence Estimate at Six Months Following a Stroke: A Cohort Study. Unknown status NCT03605381
34 Reliability of Kinematic Analysis in Assessment and Rehabilitation of the Upper Arm of Stroke Patients Following a Cerebral Vascular Accident, Hemiparetic Subjects Unknown status NCT02326688
35 The Use of Ultrasound for Botulinum Toxin Subscapularis Muscle Injection Guidance in Spastic Hemiplegic Shoulder Pain Unknown status NCT03621423
36 Tele-rehabilitation in the Home With Gaming as a Method of Improving Upper Extremity Function After Stroke Unknown status NCT02494362
37 Cardiopulmonary Rehabilitation in Chronic Stroke Patients Unknown status NCT03558542
38 Cardiovascular Function in Sub Maximal Exercise and Performance in Three Daily Activity Tests in Persons With Post Stroke Conditions Unknown status NCT01396746
39 A Multi-site, Interventional, Non-comparative, Single-arm Trial to Evaluate the Safety of the ReWalk ReStore Device in Subjects With Mobility Impairments Due to Ischemic or Hemorrhagic Stroke Unknown status NCT03499210
40 A Clinical Observational Follow-up Study of European Pediatric Cases of Acute Flaccid Myelitis Associated With EV-D68 Infection. Unknown status NCT03499366
41 Constraint Induced Movement Therapy (CIMT) in Babies Home Program Unknown status NCT01214902
42 Study on the Effectiveness of Action Observation Treatment (AOT) as a Rehabilitation Tool in Acute Stroke Patients and in Chronic Stroke Patients With Apraxia: a Randomized Controlled Trial Unknown status NCT02235350
43 The Effect of Combined Armeospring Pediatric and Constraint Induced Therapy on Neuro-motor and Functional Recovery in Children With Unilateral Cerebral Palsy Unknown status NCT02914925
44 Scalp Acupuncture for Motor Dysfunction in Ischemic Stroke: a Randomized, Controlled Trial Unknown status NCT02871453
45 Immersive Virtual Reality for Visuo-motor Integration Skill Assessment in Children With Hemiplegia Completed NCT04612049
46 The Effects of the Swiss Ball on Patients With Hemiplegia Due to Cerebral Vascular Accident Completed NCT00735033
47 Immediate Effect of Cervical Posterior Muscles' and Gluteus Medius Muscle's Vibrations on Gait in Chronic Vascular Hemiplegia Completed NCT02096367
48 Action-Observation Therapy (AOT) and Information and Communications Technologies (ICT) for Home Rehabilitation of Hemiplegia Completed NCT03094455
49 Does Transcranial Direct Current Stimulation Affect Selective Visual Attention in Children With Left-sided Infantile Hemiplegia? A Preliminary Randomized Controlled Study Completed NCT04278430
50 Evaluation of the Use of the Atalante System in Patients Presenting a Non-traumatic Hemiplegia in Acute-subacute Phase (15 Days to 6 Months). Completed NCT04187209

Search NIH Clinical Center for Hemiplegia

Cochrane evidence based reviews: hemiplegia

Genetic Tests for Hemiplegia

Anatomical Context for Hemiplegia

Organs/tissues related to Hemiplegia:

MalaCards : Brain, Cortex, Heart, Spinal Cord, Bone, Temporal Lobe, Thalamus

Publications for Hemiplegia

Articles related to Hemiplegia:

(show top 50) (show all 8445)
# Title Authors PMID Year
Effects of C2 hemisection on respiratory and cardiovascular functions in rats. 62
35900441 2023
Machine-learning prediction for hospital length of stay using a French medico-administrative database. 62
36457821 2023
This infant is having a stroke: an illustrative case report. 62
36451003 2022
Clinical Application of Acupuncture in Equine Practice. 62
36244942 2022
Motor awareness: a model based on neurological syndromes. 62
36064864 2022
Epilepsy and inborn errors of metabolism in adults: The diagnostic odyssey of a young woman with medium-chain acyl-coenzyme A dehydrogenase deficiency. 62
35869793 2022
Staphylococcus aureus meningitis complicated with intracranial hemorrhage and cerebral infarction: a case report. 62
33491526 2022
Multiple ischemic stroke with pulmonary embolism revealing severe COVID-19 infection in a young healthy patient. 62
36247700 2022
Case report: Near-complete cortical hearing loss caused by sequential development of bilateral putaminal hemorrhage. 62
36352840 2022
Endoscopic transcortical expanded transforaminal transvenous transchoroidal approach to third ventricle lesion resection using an endoport. 62
36343500 2022
The 'healthy side' of anosognosia for hemiplegia: Increased sense of agency for the unimpaired limb or motor compensation? 62
36370826 2022
Disconnections in personal neglect. 62
35670845 2022
Cerebral venous sinus thrombosis following intracerebral hemorrhage after COVID-19 AstraZeneca vaccination: A case report. 62
36397844 2022
Mechanical thrombectomy combined with stenting for radiation-induced carotid stenosis-related stroke with high-load embolization: A case report. 62
36164288 2022
Transcervical approach for carotid artery stenting without flow reversal: A case report. 62
36065238 2022
Relevance of small right-to-left shunt in contrast-enhanced transcranial Doppler in young and middle-aged patients with cryptogenic stroke: a report of two cases and literature review. 62
33401996 2022
Standing and supine positions are better than sitting in improving rightward deviation in right-hemispheric stroke patients with unilateral spatial neglect: A randomized trial. 62
36401369 2022
Diagnostic challenges of functional neurological disorders after covid-19 disease or vaccination: case series and review of the literature. 62
36413270 2022
[Analysis of clinical and imaging features of 6 cases of linear scleroderma en coup de sabre with central nervous system involvement in children]. 62
36319148 2022
Mortality Patterns Associated with Central Sleep Apnea Among Veterans: A Large, Retrospective, Longitudinal Report. 62
36375082 2022
The relationship of respiratory functions and respiratory muscle strength with trunk control, functional capacity, and functional independence in post-stroke hemiplegic patients. 62
36408866 2022
Effect of gait distance during robot training on walking independence after acute brain injury. 62
36441850 2022
Hand Exoskeleton Design and Human-Machine Interaction Strategies for Rehabilitation. 62
36421083 2022
Multiple brown tumors in primary hyperparathyroidism. 62
36120515 2022
Clinical profiles, comorbidities, and treatment outcomes of stroke in the medical ward of Dessie comprehensive specialized hospital, Northeast Ethiopia; a retrospective study. 62
36319961 2022
A Tenodesis-Induced-Grip exoskeleton robot (TIGER) for assisting upper extremity functions in stroke patients: a randomized control study. 62
34586927 2022
Hemiplegia due to hypoglycaemia followed by haemicorea after correction of glycaemic values. 62
36370205 2022
Effects of visual-motor illusions with different visual stimuli on the sit-to-stand of people with hemiplegia following stroke: A randomized crossover controlled trial. 62
36375318 2022
Use of Robotics in Gait Rehabilitation Following Stroke: A Review. 62
36475123 2022
Effects of change in walking speed on time-distance parameters in post-stroke hemiplegic gait. 62
36415831 2022
Time to hospital presentation following intracerebral haemorrhage: Proportion of patients presenting within eight hours and factors associated with delayed presentation. 62
36137452 2022
Is the Early Diagnosis of Pediatric Stroke Possible in the Emergency Department? 62
35575792 2022
Differences in causes of stiff knee gait in knee extensor activity or ankle kinematics: A cross-sectional study. 62
36166956 2022
Loss of bone mineral density in hemiplegic patients after stroke: Prospective single-center study. 62
35599071 2022
Imitation encourages empathic capacity toward other individuals with physical disabilities. 62
36283544 2022
Cerebral venous sinus thrombosis in pregnancy presenting with hemiplegia: A case report. 62
35957661 2022
Normalizing step-to-step variability to age in children and adolescents with hemiplegia. 62
35994953 2022
Walking speed influences spatiotemporal but not symmetry measures of gait in children and adolescents with hemiplegia. 62
36191582 2022
Successful endoscopic clipping management of a left atrioesophageal fistula after atrial fibrillation catheter ablation: A case report of a young male patient. 62
36187309 2022
Contrast-induced encephalopathy following endovascular treatment for intracranial aneurysms-risk factors analysis and clinical strategy. 62
36287224 2022
Pathophysiological and motor factors associated with collision avoidance behavior in individuals with stroke. 62
36278363 2022
Fatal intracerebral haemorrhage associated with thrombosis with thrombocytopenia syndrome after ChAdOx1-S vaccine. 62
36169326 2022
The left-right side-specific endocrine signaling in the effects of brain lesions: questioning of the neurological dogma. 62
36219330 2022
Developed Circuminfundibular Anastomosis Associated with Vascular Abnormalities. 62
35940505 2022
Infective Endocarditis in Hypertrophic Obstructive Cardiomyopathy After Etonogestrel Implant Removal. 62
36337782 2022
[Genetic distribution in Chinese patients with hereditary peripheral neuropathy]. 62
36241230 2022
The Phenotypic Continuum of ATP1A3-Related Disorders. 62
36192182 2022
Neuro-Physiotherapy Regimen to Enhance the Functional Performance of a Hemiplegic Patient Following Brain Tumor Resection: A Case Report. 62
36407173 2022
Systemic lupus erythematosus with diffuse intracranial calcification: A case report and review of literature. 62
36031867 2022
Sjögren's Syndrome Presenting with Temporary Hemiplegia Mimicking Transient Ischemic Attack. 62
36155592 2022

Variations for Hemiplegia

ClinVar genetic disease variations for Hemiplegia:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ATP1A3 NM_152296.5(ATP1A3):c.2839G>A (p.Gly947Arg) SNV Pathogenic
37110 rs398122887 GRCh37: 19:42471896-42471896
GRCh38: 19:41967744-41967744
2 ATP1A3 NM_152296.5(ATP1A3):c.2443G>A (p.Glu815Lys) SNV Pathogenic
37108 rs387907281 GRCh37: 19:42474436-42474436
GRCh38: 19:41970284-41970284
3 ATP1A3 NM_152296.5(ATP1A3):c.958G>C (p.Ala320Pro) SNV Likely Pathogenic
523558 rs879255368 GRCh37: 19:42489105-42489105
GRCh38: 19:41984953-41984953
4 ATP1A2 NM_000702.4(ATP1A2):c.953C>A (p.Ala318Glu) SNV Uncertain Significance
1372546 GRCh37: 1:160097546-160097546
GRCh38: 1:160127756-160127756
5 MYH6 NM_002471.4(MYH6):c.3195G>C (p.Gln1065His) SNV Uncertain Significance
14149 rs267606904 GRCh37: 14:23862177-23862177
GRCh38: 14:23392968-23392968
6 DSP NM_004415.4(DSP):c.5218G>A (p.Glu1740Lys) SNV Uncertain Significance
44926 rs142885240 GRCh37: 6:7581641-7581641
GRCh38: 6:7581408-7581408
7 MYH6 NM_002471.4(MYH6):c.4594C>T (p.Arg1532Cys) SNV Uncertain Significance
239175 rs201827489 GRCh37: 14:23856794-23856794
GRCh38: 14:23387585-23387585
8 SCN5A NM_000335.5(SCN5A):c.892G>A (p.Gly298Ser) SNV Uncertain Significance
9387 rs137854608 GRCh37: 3:38651267-38651267
GRCh38: 3:38609776-38609776

Expression for Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for Hemiplegia

Pathways related to Hemiplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 13.27 TAC1 S100B RHOBTB2 PDHA1 MMP9 EDN1
Show member pathways
3 11.7 SLC2A1 SLC1A3 SLC1A1 PDHA1
4 11.63 SLC1A3 SLC1A1 SCN1A S100B ENO2 CALCA
5 11.53 SLC2A1 SLC1A3 S100B
6 11.41 MMP9 EDN1 CALCA
7 11.37 MMP9 COL4A2 COL4A1
8 11.25 SLC1A3 CACNA1A ATP1A2
9 10.7 SLC2A1 PDHA1 EDN1

GO Terms for Hemiplegia

Cellular components related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.7 TAC1 SLC2A1 SLC1A3 SLC1A1 CACNA1A ATP1A3
2 intercalated disc GO:0014704 9.63 SLC2A1 SCN1A ATP1A2
3 neuronal cell body GO:0043025 9.6 TAC1 SLC1A3 SLC1A1 SCN1A S100B ENO2
4 collagen type IV trimer GO:0005587 9.56 COL4A2 COL4A1

Biological processes related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to xenobiotic stimulus GO:0009410 10.06 SLC1A3 SLC1A1 ENO2 EDN1 BGLAP
2 response to activity GO:0014823 9.97 EDN1 COL4A2 BGLAP
3 monoatomic ion transport GO:0006811 9.92 SLC1A3 SLC1A1 SCN1A CACNA1A ATP1A3 ATP1A2
4 transport across blood-brain barrier GO:0150104 9.86 SLC2A1 SLC1A3 SLC1A1 ATP1A2
5 L-glutamate import across plasma membrane GO:0098712 9.83 SLC1A3 SLC1A1
6 cellular response to cocaine GO:0071314 9.81 SLC1A3 SLC1A1
7 L-aspartate import across plasma membrane GO:0140009 9.78 SLC1A3 SLC1A1
8 response to glycoside GO:1903416 9.76 ATP1A3 ATP1A2
9 D-aspartate import across plasma membrane GO:0070779 9.73 SLC1A3 SLC1A1
10 L-glutamate import GO:0051938 9.67 SLC1A1 SLC1A3
11 blood vessel morphogenesis GO:0048514 9.55 SLC1A1 EDN1 COL4A1
12 cellular sodium ion homeostasis GO:0006883 9.43 SLC1A3 ATP1A3 ATP1A2
13 positive regulation of cytosolic calcium ion concentration GO:0007204 9.32 TAC1 EDN1 CALCA CACNA1A ADCY5

Molecular functions related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.62 ATP1A3 ATP1A2
2 steroid hormone binding GO:1990239 9.56 ATP1A3 ATP1A2
3 glutamate:sodium symporter activity GO:0015501 9.46 SLC1A3 SLC1A1
4 high-affinity L-glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A3 SLC1A1
5 P-type potassium transmembrane transporter activity GO:0008556 8.62 ATP1A3 ATP1A2

Sources for Hemiplegia

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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