Aliases & Classifications for Hemiplegia

MalaCards integrated aliases for Hemiplegia:

Name: Hemiplegia 12 74 6 43 15 17 32
Postnatal Infantile Hemiplegia 12
Hemiplegia, Infantile 71
Infantile Hemiplegia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10969
ICD9CM 34 343.4
MeSH 43 D006429
SNOMED-CT 67 1593000
ICD10 32 G81 G81.9
UMLS 71 C0392550

Summaries for Hemiplegia

Disease Ontology : 12 A central nervous system disease that is characterized by the complete paralysis of half of the body.

MalaCards based summary : Hemiplegia, also known as postnatal infantile hemiplegia, is related to familial porencephaly and alternating hemiplegia of childhood. An important gene associated with Hemiplegia is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Circadian entrainment. The drugs Succinylcholine and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Hemiparesis, or unilateral paresis, is weakness of one entire side of the body (hemi- means "half").... more...

Related Diseases for Hemiplegia

Diseases related to Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 585)
# Related Disease Score Top Affiliating Genes
1 familial porencephaly 34.0 COL4A2 COL4A1
2 alternating hemiplegia of childhood 33.2 TAC1 SLC2A1 SLC1A3 SCN1A PNKD MMP9
3 hemiplegic migraine 32.6 SLC2A1 SCN1A CALCA CACNA1A ATP1A3 ATP1A2
4 familial hemiplegic migraine 32.4 SLC1A3 SCN1A CALCA CACNA1A ATP1A3 ATP1A2
5 episodic ataxia 32.2 SLC1A3 SLC1A1 SCN1A PNKD CACNA1A ATP1A3
6 status epilepticus 31.1 SCN1A ENO2 CACNA1A
7 epilepsy 31.1 SLC2A1 SCN1A S100B CACNA1A ATP1A3 ATP1A2
8 movement disease 31.0 SLC2A1 PNKD CACNA1A ATP1A3
9 dystonia 31.0 SLC2A1 PNKD CACNA1A ATP1A3 ADCY5
10 head injury 30.9 S100B ENO2
11 headache 30.7 TAC1 SCN1A CALCA CACNA1A ATP1A2
12 traumatic brain injury 30.5 S100B MMP9 ENO2
13 aceruloplasminemia 30.4 SLC2A1 SLC1A3 CACNA1A ATP1A3
14 col4a1-related familial vascular leukoencephalopathy 30.4 COL4A2 COL4A1
15 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 30.3 COL4A1 CACNA1A ATP1A2
16 episodic ataxia, type 2 30.3 SCN1A PNKD CACNA1A ATP1A2
17 middle cerebral artery infarction 30.2 S100B ENO2 EDN1
18 migraine with or without aura 1 30.2 TAC1 SLC1A3 SCN1A PNKD EDN1 CALCA
19 lennox-gastaut syndrome 30.1 SLC2A1 SCN1A CACNA1A
20 complex regional pain syndrome 30.1 TAC1 EDN1 CALCA
21 epileptic encephalopathy, early infantile, 6 30.1 SLC2A1 SCN1A CACNA1A ATP1A2
22 patent foramen ovale 29.9 RNF213 MYH6 EDN1 ATP1A2
23 early infantile epileptic encephalopathy 29.9 SLC2A1 SCN1A CACNA1A ATP1A3 ATP1A2
24 akinetic mutism 29.9 S100B ENO2
25 benign epilepsy with centrotemporal spikes 29.9 SLC2A1 SCN1A PNKD CACNA1A ATP1A2
26 acute mountain sickness 29.8 S100B ENO2 EDN1
27 gastroenteritis 29.8 SCN1A MMP9 CALCA
28 hepatic encephalopathy 29.7 SLC1A1 S100B MMP9
29 bronchitis 29.5 TAC1 MMP9 CALCA
30 migraine with aura 29.3 SLC2A1 SCN1A EDN1 CALCA CACNA1A ATP1A3
31 tetralogy of fallot 29.3 MYH6 MMP9 ENO2 EDN1 CALCA
32 spastic hemiplegia 12.8
33 alternating hemiplegia of childhood 2 12.7
34 idiopathic hemiconvulsion-hemiplegia syndrome 12.7
35 alternating hemiplegia of childhood 1 12.6
36 hemiplegia alterans 12.4
37 benign nocturnal alternating hemiplegia of childhood 12.3
38 epileptic hemiplegia 12.3
39 brain small vessel disease 1 with or without ocular anomalies 12.1
40 porencephaly 11.6
41 moyamoya disease 1 11.4
42 spastic cerebral palsy 11.4
43 episodic ataxia, type 6 11.4
44 medial medullary syndrome 11.3
45 brain small vessel disease 2 11.3
46 brown-sequard syndrome 11.3
47 sulfite oxidase deficiency, isolated 11.1
48 moyamoya disease 2 11.1
49 moyamoya disease 5 11.1
50 moyamoya disease 6 with or without achalasia 11.1

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to Hemiplegia

Symptoms & Phenotypes for Hemiplegia

UMLS symptoms related to Hemiplegia:


hemiplegia

MGI Mouse Phenotypes related to Hemiplegia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 ADCY5 ATP1A2 ATP1A3 CACNA1A COL4A1 ENO2
2 homeostasis/metabolism MP:0005376 10.13 ADCY5 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2
3 nervous system MP:0003631 9.77 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 EDN1
4 muscle MP:0005369 9.76 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 EDN1
5 respiratory system MP:0005388 9.28 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 ENO2

Drugs & Therapeutics for Hemiplegia

Drugs for Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Succinylcholine Approved Phase 4 306-40-1 5314
2
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
3
Baclofen Approved Phase 4 1134-47-0 2284
4 Gastrodia Phase 4
5 Neuromuscular Blocking Agents Phase 4
6 Neurotransmitter Agents Phase 4
7 Acetylcholine Release Inhibitors Phase 4
8 Cholinergic Agents Phase 4
9 Botulinum Toxins Phase 4
10 abobotulinumtoxinA Phase 4
11 Neuromuscular Agents Phase 4
12 Botulinum Toxins, Type A Phase 4
13 rimabotulinumtoxinB Phase 2, Phase 3
14
Glycerol Approved, Investigational Phase 2 56-81-5 753
15
Sodium oxybate Approved Phase 1, Phase 2 502-85-2 5360545
16
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
17
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
18 Carbon Fiber Phase 1, Phase 2
19 Anesthetics, General Phase 1, Phase 2
20 Adjuvants, Anesthesia Phase 1, Phase 2
21 Anesthetics, Intravenous Phase 1, Phase 2
22 Hormone Antagonists Phase 2
23 Anti-Inflammatory Agents Phase 2
24 glucocorticoids Phase 2
25 Hormones Phase 2
26 Anesthetics, Local Phase 2
27 Anti-Arrhythmia Agents Phase 2
28 Sodium Channel Blockers Phase 2
29 Diuretics, Potassium Sparing Phase 2
30 Immunologic Factors Phase 2
31 triamcinolone acetonide Phase 2
32 Triamcinolone diacetate Phase 2
33 Triamcinolone hexacetonide Phase 2
34 Immunosuppressive Agents Phase 2
35 Passionflower Phase 1, Phase 2
36
Dopamine Approved Phase 1 51-61-6, 62-31-7 681
37
Methamphetamine Approved, Illicit Phase 1 537-46-2 10836
38
Sodium citrate Approved, Investigational Phase 1 68-04-2
39
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
40
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
41 Autonomic Agents Phase 1
42 Sympathomimetics Phase 1
43 Central Nervous System Stimulants Phase 1
44 Dopamine Uptake Inhibitors Phase 1
45 Dopamine Agents Phase 1
46 Adrenergic Agents Phase 1
47 Anesthetics Phase 1
48 Citrate Phase 1
49 Anticoagulants Phase 1
50 Chelating Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 325)
# Name Status NCT ID Phase Drugs
1 Functional Electrical Stimulation (FES)-Assisted Walking: Enhancement of Voluntary Walking Function Among Persons With Severe Hemiplegia Post-Stroke Unknown status NCT00552916 Phase 4
2 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
3 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
4 Multi-center, Single Arm, Open-label, Phase IV Clinical Trial to Evaluate the Safety and Efficacy of MEDITOXIN® in Children With Cerebral Palsy Completed NCT01256021 Phase 4 Botulinum Toxin Type A
5 Characterizing Fade Upon Train-of Four Stimulation During Onset and Offset of Neuromuscular Block Produced by Succinlycholine Completed NCT02425449 Phase 4 Succinylcholine
6 Randomised Controlled Trial to Evaluate the Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity (Repeated Botulinum Toxin Injections and Physiotherapy) on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Recruiting NCT02944929 Phase 4
7 Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen. Recruiting NCT02462317 Phase 4 botulinum A toxin;Baclofen;Placebo toxin;placebo baclofen
8 Research Assistant Doctor Not yet recruiting NCT03860662 Phase 4 Botox;Baclofen
9 Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing the Antispastic Efficacy and Safety of Dynamic Night Hand Splinting in Adults With Post-stroke Hemiplegia Treated by Botulimum Toxin (Dysport®) - (a Pilot Study) Not yet recruiting NCT02888548 Phase 4
10 Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
11 Comparison of Surface Landmark, Ultrasonography and Electric Stimulation Guidance for Botulinum Toxin Injections in Stroke Patients With Spasticity on Upper Extremities. Unknown status NCT02557737 Phase 3 Botulinum Toxin Type A
12 Modulation of Brain Plasticity After Perinatal Stroke: The PLASTIC CHAMPS Trial Unknown status NCT01189058 Phase 2, Phase 3
13 Double-blinded, Randomized, Active Control Comparative, Multicenter-designed, Phase III Clinical Trial to Evaluate the Safety and Efficacy of "Botulax®" Versus "Botox®" in Children With Cerebral Palsy Completed NCT01787344 Phase 3 Botulinum Toxin Type A(Botox®);Botulinum toxin type A(Botulax®)
14 Assisted Movement Neuro-rehabilitation: VA Multi-site Clinical Trial Completed NCT00223808 Phase 3
15 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
16 Transcranial Direct Current Stimulation and Robotic Training in Chronic Stroke Completed NCT03562663 Phase 3
17 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
18 Is it Possible to Improve Static and Dynamic Postural Stability in Cerebral Palsy Children by Modulating Attention? Completed NCT01799304 Phase 3
19 Combined Inspiratory and Expiratory Muscle Training in Long-term Stroke Completed NCT02828943 Phase 3
20 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
21 Burke-Hocoma Efficiency Study Enrolling by invitation NCT03555825 Phase 3
22 A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity Followed by an Open-Label Extension, Multiple-Treatment Safety Study of MYOBLOC Not yet recruiting NCT04099667 Phase 2, Phase 3 rimabotulinumtoxinB;Placebo
23 Effects of the Quantity of Repetitive Transcranial Magnetic Stimulation on the Recovery of Upper Motor Function After Stroke: a Randomized Controlled Trial Terminated NCT01311271 Phase 2, Phase 3
24 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
25 Randomized Clinical Trial of Hand Arm Bimanual Intensive Therapy (HABIT) Unknown status NCT01413594 Phase 1, Phase 2
26 Effet de la réadaptation Sur Les déficiences, Limitations d'activité et Restriction de la Participation Des Enfants présentant Des lésions Neurologiques Non-évolutives (Infirmes Moteurs cérébraux). Unknown status NCT01700777 Phase 1, Phase 2
27 "Etude Pilote, Comparative, Monocentrique, randomisée, en Cross Over, en Double Aveugle, Contre Placebo, Testant l'efficacité de l'Huile triheptanoïne Dans Les Hémiplégies Alternantes de l'Enfant" HEMIHEP Unknown status NCT02408354 Phase 2 Triheptanoin;Placebo
28 Rehabilitation of Early Stroke Patients Using a Custom-made Solid Ankle-foot Orthosis: a Randomised Controlled Trial Unknown status NCT01006772 Phase 1, Phase 2
29 Treating Apoplectic Sequela With Acupuncture: a Randomized Controlled Study Unknown status NCT01003470 Phase 2
30 Modified Constraint-Induced Movement Therapy and Eye Patching for Neglect Rehabilitation Post Stroke: A Longitudinal Study of Separate and Combined Effects Unknown status NCT00253825 Phase 1, Phase 2
31 Improving Treatment of People With Movement Disorders in the Middle East Unknown status NCT01466296 Phase 2
32 Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction After Stroke Unknown status NCT01010607 Phase 1, Phase 2
33 A Phase 2 Study of HC-58 in Patients With Severe Upper Limb Hemiplegia After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
34 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity in the Affected Leg of Hemiplegics Completed NCT01569386 Phase 2
35 Single-center Phase I/II Trial of Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO Trial) Completed NCT00931164 Phase 1, Phase 2 Sodium Oxybate
36 Suprascapular Nerve Block in Hemiplegic Shoulder Pain. Completed NCT00732589 Phase 2 1% xylocaine
37 Contralaterally Controlled Functional Electrical Stimulation for Hemiparetic Hand Completed NCT00565045 Phase 1, Phase 2
38 A Feasibility Trial to Evaluate the MindFrame System in the Recanalization of Occluded Vessels in Patients Experiencing an Ischemic Stroke Completed NCT00810095 Phase 2
39 Robot Assisted Upper Limb Neuro-Rehabilitation Completed NCT00011583 Phase 2
40 Auditory Rhythm Cues + Task Practice: Effects on UE Motor Function Post-stroke Completed NCT00523523 Phase 1, Phase 2
41 The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy Completed NCT00619853 Phase 2
42 Subacute Stroke Recovery (Upper Extremity Motor Function): Bimanual Coordination Training Completed NCT00369668 Phase 2
43 Video-Based Functional Performance and Assessment Following Stroke Completed NCT00013494 Phase 2
44 FNS and Weight Support Treadmill Training for Gait Component Restoration Completed NCT00011596 Phase 2
45 Evaluation of Therapeutic Effects of Navigation-guided 1 Hz rTMS Administered to the Contralesional Hemisphere in Patients With Stroke Completed NCT01049802 Phase 1, Phase 2
46 Clinical Trials in Stroke Rehabilitation Completed NCT00597766 Phase 2 Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine
47 THE IMMEDIATE EFFECT OF ELECTRICAL STIMULATION TRANSCRANIAL DIRECT CURRENT (tDCS) ON CARDIORESPIRATORY PARAMETERS IN HEMIPARETICS ADULTS PATIENTS DUE TO STROKE Completed NCT02398344 Phase 1, Phase 2
48 Randomised Controlled Trial to Compare Two Methods of Constraint Induced Movement Therapy to Improve Functional Ability in the Affected Upper Limb in Pre-school Children With Hemiplegic Cerebral Palsy Completed NCT01770678 Phase 2
49 Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia Enrolling by invitation NCT02987855 Phase 1, Phase 2
50 Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) Not yet recruiting NCT03356821 Phase 1, Phase 2

Search NIH Clinical Center for Hemiplegia

Cochrane evidence based reviews: hemiplegia

Genetic Tests for Hemiplegia

Anatomical Context for Hemiplegia

MalaCards organs/tissues related to Hemiplegia:

40
Brain, Testes, Bone, Heart, Cortex, Spinal Cord, Skin

Publications for Hemiplegia

Articles related to Hemiplegia:

(show top 50) (show all 7468)
# Title Authors PMID Year
1
The effect of using Gait Exercise Assist Robot (GEAR) on gait pattern in stroke patients: a cross-sectional pilot study. 61
31483736 2020
2
Hippocampal diaschisis contributes to anosognosia for hemiplegia: Evidence from lesion network-symptom-mapping. 61
31870945 2020
3
Mechanical Thrombectomy in Pediatric Stroke: Report of Three New Cases. 61
31843352 2020
4
[Analysis of the concept of the Zika Virus congenital syndrome]. 61
32022196 2020
5
Biopsy histopathology in the diagnosis of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). 61
31705326 2020
6
Random forest-based classsification and analysis of hemiplegia gait using low-cost depth cameras. 61
31853775 2020
7
Residual Deficits of Knee Flexors and Plantar Flexors Predict Normalized Walking Performance in Patients with Poststroke Hemiplegia. 61
32037268 2020
8
Surface Electromyography-Controlled Automobile Steering Assistance. 61
32024313 2020
9
Social impairments in alternating hemiplegia of childhood. 61
32031250 2020
10
Ketamine Infusion for Super Refractory Status Epilepticus in Alternating Hemiplegia of Childhood. 61
32016945 2020
11
Altered Brain Regional Homogeneity Following Contralateral Acupuncture at Quchi (LI 11) and Zusanli (ST 36) in Ischemic Stroke Patients with Left Hemiplegia: An fMRI Study. 61
31776964 2020
12
A Successful Treatment Strategy for Paradoxical Cerebral Embolism Accompanied by Entrapped Thrombus in Patent Foramen Ovale. 61
31484914 2020
13
Medullary Compression Due to Ectatic Vertebral Artery-Case Report and Review of Literature. 61
31699578 2020
14
Predicting walking ability in hemiplegic patients with putaminal hemorrhage: an observational study in a rehabilitation hospital. 61
31976635 2020
15
The effect of EMG biofeedback on lower extremity functions in hemiplegic patients. 61
31898758 2020
16
Rare giant primary intracranial angioleiomyoma in lateral ventricle: a case report and the literature review. 61
32003238 2020
17
The Role of Circular RNAs in Brain Injury. 61
31917349 2020
18
Clinical and Genetic Spectrum of ATP1A3-Related Disorders in a Korean Pediatric Population. 61
31942761 2020
19
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. 61
31959558 2020
20
Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations. 61
30690204 2020
21
Assessing stroke severity using electronic health record data: a machine learning approach. 61
31914991 2020
22
Contralateral cervical seventh nerve transfer for spastic arm paralysis via a modified prespinal route: a cadaveric study. 61
31741113 2020
23
[Impact of hypoxic-ischemic injury on brain development in neonatal rats of different sexes]. 61
31905473 2020
24
Modified split tendon transfer of posterior tibialis muscle in the treatment of spastic equinovarus foot deformity: long-term results and comparison with the standard procedure. 61
31740994 2020
25
Evaluation of the bilateral function in para-athletes with spastic hemiplegia: A model-based clustering approach. 61
31956044 2020
26
Decreased mitochondrial DNA copy number in children with cerebral palsy quantified by droplet digital PCR. 61
31978410 2020
27
Predicting 6-Month Mortality in Incident Elderly Dialysis Patients: A Simple Prognostic Score. 61
31825925 2020
28
Effect of unstable surface sitting on paretic anterior tibial muscle following stroke. 61
31987556 2020
29
[Cavernous sinus syndrome secondary to thrombophlebitis due to Streptococcus intermedius complicated with vasculitis of the internal carotid artery and brain abscesses]. 61
31845752 2020
30
Trousseau's syndrome associated with pulmonary pleomorphic carcinoma exhibiting aggressive features: A case report. 61
31814975 2020
31
White matter and cerebellar involvement in alternating hemiplegia of childhood. 61
31950366 2020
32
Cerebral arterial air embolism secondary to iatrogenic left atrial-esophageal fistula: a case report. 61
31926563 2020
33
Delayed Rebleeding from Pseudoaneurysm After Mechanical Thrombectomy Using Stent Retriever Due to Small Artery Avulsion Confirmed by Open Surgery. 61
31589986 2020
34
Understanding Anosognosia for Hemiplegia After Stroke. 61
31876873 2020
35
Understanding Anosognosia for Hemiplegia After Stroke. 61
30086101 2020
36
[A Case of Atypical Meningioma with Liver Metastasis at 9 Years after Initial Surgery]. 61
31983690 2020
37
A review of physical modalities and the potential to expand the treatment of patients with traumatic brain injury. 61
31032621 2019
38
Effects of dual tasking on postural and gait performances in children with cerebral palsy and healthy children. 61
31722225 2019
39
Ultrasound measurements of the median nerve at the carpal tunnel in ambulant chronic stroke patients: comparison between paretic and non-paretic sides. 61
32038071 2019
40
Retraction Notice to "Accelerated Bone Remodeling in Patients with Poststroke Hemiplegia" [Journal of Stroke and Cerebrovascular Diseases, Volume 7, Issue 1, January-February 1998, Pages 58 - 62]. 61
31784024 2019
41
Epilepsy and brain channelopathies from infancy to adulthood. 61
31838630 2019
42
Surgical treatment of spontaneous brainstem hemorrhage: A case report. 61
31861010 2019
43
Botany, traditional uses, phytochemistry, pharmacology and toxicology of Ilex pubescens Hook et Arn. 61
31401319 2019
44
Median Nerve Electrical Stimulation-Induced Changes in Effective Connectivity in Patients With Stroke as Assessed With Functional Near-Infrared Spectroscopy. 61
31550986 2019
45
Improving balance with wobble board exercises in stroke patients: single-blind, randomized clinical trial. 61
31348727 2019
46
Plyometric exercises: subsequent changes of weight-bearing symmetry, muscle strength and walking performance in children with unilateral cerebral palsy. 61
31789302 2019
47
Contralateral seventh cervical nerve transfer can affect the pennation angle of the lower limb in spastic hemiplegia patients: An observational case series study. 61
31721481 2019
48
Architecture of the Triceps Surae Muscles Complex in Patients with Spastic Hemiplegia: Implication for the Limited Utility of the Silfverskiöld Test. 61
31805732 2019
49
Risk factors for long-term care after hemiplegia from cancer-related brain surgery: a pilot study for new prediction model. 61
31556509 2019
50
[Hemiconvulsion-hemiplegia-epilepsy syndrome: case report and use of dextromethorphan]. 61
31762002 2019

Variations for Hemiplegia

ClinVar genetic disease variations for Hemiplegia:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ATP1A3 NM_152296.5(ATP1A3):c.2443G>A (p.Glu815Lys)SNV Pathogenic 37108 rs387907281 19:42474436-42474436 19:41970284-41970284
2 ATP1A3 NM_152296.5(ATP1A3):c.2839G>A (p.Gly947Arg)SNV Pathogenic 37110 rs398122887 19:42471896-42471896 19:41967744-41967744
3 ATP1A3 NM_152296.5(ATP1A3):c.958G>C (p.Ala320Pro)SNV Likely pathogenic 523558 rs879255368 19:42489105-42489105 19:41984953-41984953
4 MYH6 NM_002471.3(MYH6):c.3195G>C (p.Gln1065His)SNV Conflicting interpretations of pathogenicity 14149 rs267606904 14:23862177-23862177 14:23392968-23392968
5 DSP NM_004415.4(DSP):c.5218G>A (p.Glu1740Lys)SNV Conflicting interpretations of pathogenicity 44926 rs142885240 6:7581641-7581641 6:7581408-7581408
6 MYH6 NM_002471.3(MYH6):c.4594C>T (p.Arg1532Cys)SNV Conflicting interpretations of pathogenicity 239175 rs201827489 14:23856794-23856794 14:23387585-23387585
7 SCN5A NM_198056.2(SCN5A):c.892G>A (p.Gly298Ser)SNV Uncertain significance 9387 rs137854608 3:38651267-38651267 3:38609776-38609776

Expression for Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for Hemiplegia

Pathways related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 SLC2A1 EDN1 ATP1A3 ATP1A2 ADCY5
2
Show member pathways
12.58 SLC1A3 SLC1A1 SCN1A CACNA1A ADCY5
3
Show member pathways
12.52 SLC1A1 MMP9 COL4A2 COL4A1 ATP1A3 ATP1A2
4 12.46 SLC2A1 MMP9 EDN1 COL4A2 COL4A1 ADCY5
5
Show member pathways
12.43 MMP9 EDN1 COL4A2 COL4A1 ADCY5
6
Show member pathways
12.39 TAC1 SCN1A ATP1A3 ATP1A2 ADCY5
7 12.13 EDN1 ATP1A3 ATP1A2 ADCY5
8
Show member pathways
11.78 SLC1A3 SLC1A1 CACNA1A ATP1A2
9 11.74 ATP1A3 ATP1A2 ADCY5
10 11.72 EDN1 COL4A2 COL4A1
11 11.65 MYH6 ATP1A3 ATP1A2
12 11.63 SLC1A3 SLC1A1 SCN1A S100B ENO2 CALCA
13 11.6 SLC2A1 SLC1A3 S100B
14 11.53 SLC2A1 MYH6 ATP1A3 ATP1A2
15 11.45 MMP9 EDN1 CALCA
16 11.42 MMP9 COL4A2 COL4A1
17 11.11 SLC2A1 ATP1A3 ATP1A2 ADCY5

GO Terms for Hemiplegia

Cellular components related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.91 TAC1 EDN1 CALCA CACNA1A ATP1A3 ATP1A2
2 synapse GO:0045202 9.8 TAC1 SLC1A3 SLC1A1 CACNA1A ATP1A3 ATP1A2
3 extracellular space GO:0005615 9.61 TAC1 S100B MMP9 ENO2 EDN1 COL4A2
4 sodium:potassium-exchanging ATPase complex GO:0005890 9.4 ATP1A3 ATP1A2
5 intercalated disc GO:0014704 9.33 SLC2A1 SCN1A ATP1A2
6 collagen type IV trimer GO:0005587 9.26 COL4A2 COL4A1
7 neuronal cell body GO:0043025 9.23 TAC1 SLC1A3 SCN1A S100B ENO2 CALCA

Biological processes related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.95 SLC1A3 SLC1A1 SCN1A CACNA1A ATP1A3 ATP1A2
2 ion transmembrane transport GO:0034220 9.92 SCN1A CACNA1A ATP1A3 ATP1A2
3 chemical synaptic transmission GO:0007268 9.85 TAC1 SLC1A3 SLC1A1 CACNA1A
4 neuromuscular process controlling balance GO:0050885 9.63 SLC1A3 CACNA1A ADCY5
5 L-glutamate transmembrane transport GO:0015813 9.62 SLC1A3 SLC1A1
6 response to amyloid-beta GO:1904645 9.61 MMP9 CACNA1A
7 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.61 ATP1A3 ATP1A2
8 response to activity GO:0014823 9.61 EDN1 COL4A2 BGLAP
9 positive regulation of renal sodium excretion GO:0035815 9.6 TAC1 EDN1
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.59 ATP1A3 ATP1A2
11 cellular response to steroid hormone stimulus GO:0071383 9.58 ATP1A3 ATP1A2
12 neuromuscular process controlling posture GO:0050884 9.58 SCN1A PNKD
13 sodium ion export across plasma membrane GO:0036376 9.57 ATP1A3 ATP1A2
14 cellular potassium ion homeostasis GO:0030007 9.56 ATP1A3 ATP1A2
15 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.54 COL4A2 COL4A1
16 neurotransmitter uptake GO:0001504 9.52 SLC1A3 ATP1A2
17 regulation of glucose transmembrane transport GO:0010827 9.51 SLC2A1 EDN1
18 L-glutamate import across plasma membrane GO:0098712 9.49 SLC1A3 SLC1A1
19 response to glycoside GO:1903416 9.4 ATP1A3 ATP1A2
20 D-aspartate import across plasma membrane GO:0070779 9.37 SLC1A3 SLC1A1
21 positive regulation of cytosolic calcium ion concentration GO:0007204 9.35 TAC1 EDN1 CALCA CACNA1A ADCY5
22 response to pain GO:0048265 9.33 TAC1 CALCA CACNA1A
23 L-glutamate import GO:0051938 9.32 SLC1A3 SLC1A1
24 L-aspartate import across plasma membrane GO:0140009 9.26 SLC1A3 SLC1A1
25 regulation of blood pressure GO:0008217 9.02 TAC1 MYH6 EDN1 CALCA ATP1A2

Molecular functions related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.73 SLC1A3 SLC1A1 S100B RNF213 PNKD MMP9
2 L-glutamate transmembrane transporter activity GO:0005313 9.43 SLC1A3 SLC1A1
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.4 ATP1A3 ATP1A2
4 glutamate binding GO:0016595 9.37 SLC1A3 SLC1A1
5 potassium-transporting ATPase activity GO:0008556 9.32 ATP1A3 ATP1A2
6 steroid hormone binding GO:1990239 9.26 ATP1A3 ATP1A2
7 high-affinity glutamate transmembrane transporter activity GO:0005314 9.16 SLC1A3 SLC1A1
8 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A3 SLC1A1

Sources for Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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