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MCID: HMP005
MIFTS: 55

Hemiplegia

Categories: Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hemiplegia

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MalaCards integrated aliases for Hemiplegia:

Name: Hemiplegia 12 74 6 43 15 17 32
Postnatal Infantile Hemiplegia 12
Hemiplegia, Infantile 71
Infantile Hemiplegia 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10969
ICD9CM 34 343.4
MeSH 43 D006429
SNOMED-CT 67 1593000
ICD10 32 G81 G81.9
UMLS 71 C0392550
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Summaries for Hemiplegia

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Disease Ontology : 12 A central nervous system disease that is characterized by the complete paralysis of half of the body.

MalaCards based summary : Hemiplegia, also known as postnatal infantile hemiplegia, is related to brain small vessel disease 1 with or without ocular anomalies and familial porencephaly. An important gene associated with Hemiplegia is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Circadian entrainment. The drugs Succinylcholine and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Hemiparesis, or unilateral paresis, is weakness of one entire side of the body (hemi- means "half").... more...

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Related Diseases for Hemiplegia

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Diseases related to Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 595)
# Related Disease Score Top Affiliating Genes
1 brain small vessel disease 1 with or without ocular anomalies 34.0 COL4A2 COL4A1
2 familial porencephaly 34.0 COL4A2 COL4A1
3 alternating hemiplegia of childhood 33.3 TAC1 SLC2A1 SLC1A3 SCN1A PNKD MMP9
4 episodic ataxia, type 6 32.8 SLC1A3 SLC1A1 CACNA1A
5 familial hemiplegic migraine 32.4 SLC1A3 SCN1A CALCA CACNA1A ATP1A3 ATP1A2
6 episodic ataxia 32.3 SLC1A3 SLC1A1 SCN1A PNKD CACNA1A ATP1A3
7 status epilepticus 31.2 SCN1A ENO2 CACNA1A
8 movement disease 31.0 SLC2A1 PNKD CACNA1A ATP1A3
9 head injury 30.9 S100B ENO2
10 epilepsy 30.7 SLC2A1 SLC1A1 SCN1A S100B CACNA1A ATP1A3
11 headache 30.7 TAC1 SCN1A CALCA CACNA1A ATP1A2
12 traumatic brain injury 30.6 S100B MMP9 ENO2
13 dystonia 12 30.5 SLC2A1 CACNA1A ATP1A3
14 migraine, familial hemiplegic, 1 30.4 SLC1A3 SCN1A CACNA1A ATP1A2
15 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 30.3 COL4A2 COL4A1 ATP1A2
16 episodic ataxia, type 2 30.3 SCN1A PNKD CACNA1A ATP1A2
17 middle cerebral artery infarction 30.2 S100B ENO2 EDN1
18 episodic ataxia, type 1 30.2 SCN1A PNKD CACNA1A
19 col4a1-related familial vascular leukoencephalopathy 30.2 COL4A2 COL4A1
20 complex regional pain syndrome 30.1 TAC1 EDN1 CALCA
21 leukoencephalopathy, hereditary diffuse, with spheroids 30.1 SLC1A3 SCN1A S100B
22 epileptic encephalopathy, early infantile, 6 30.1 SLC2A1 SCN1A CACNA1A ATP1A2
23 migraine, familial hemiplegic, 2 30.0 SLC1A3 SCN1A CACNA1A ATP1A3 ATP1A2
24 benign epilepsy with centrotemporal spikes 30.0 SLC2A1 SCN1A PNKD ATP1A2
25 patent foramen ovale 30.0 RNF213 MYH6 EDN1 ATP1A2
26 akinetic mutism 30.0 S100B ENO2
27 early infantile epileptic encephalopathy 29.9 SLC2A1 SCN1A CACNA1A ATP1A3 ATP1A2
28 acute mountain sickness 29.9 S100B ENO2 EDN1
29 hepatic encephalopathy 29.7 SLC1A1 S100B MMP9
30 migraine with or without aura 1 29.5 TAC1 SLC1A3 SCN1A S100B PNKD MMP9
31 tetralogy of fallot 29.4 MYH6 MMP9 ENO2 EDN1 CALCA
32 migraine with aura 29.0 TAC1 SLC2A1 SLC1A3 SCN1A EDN1 CALCA
33 spastic hemiplegia 12.8
34 alternating hemiplegia of childhood 2 12.7
35 idiopathic hemiconvulsion-hemiplegia syndrome 12.7
36 alternating hemiplegia of childhood 1 12.7
37 hemiplegia alterans 12.4
38 benign nocturnal alternating hemiplegia of childhood 12.3
39 epileptic hemiplegia 12.3
40 porencephaly 11.6
41 moyamoya disease 1 11.4
42 spastic cerebral palsy 11.4
43 medial medullary syndrome 11.3
44 brain small vessel disease 2 11.3
45 mitochondrial complex v deficiency, nuclear type 6 11.3
46 brown-sequard syndrome 11.3
47 sulfite oxidase deficiency, isolated 11.1
48 moyamoya disease 2 11.1
49 moyamoya disease 5 11.1
50 moyamoya disease 6 with or without achalasia 11.1

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to Hemiplegia
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Symptoms & Phenotypes for Hemiplegia

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UMLS symptoms related to Hemiplegia:


hemiplegia

GenomeRNAi Phenotypes related to Hemiplegia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.28 ATP1A3 CACNA1A
2 Decreased viability GR00381-A-1 9.28 CALCA
3 Decreased viability GR00386-A-1 9.28 ATP1A3 MYH6 SLC1A3 SLC2A1
4 Decreased viability GR00402-S-2 9.28 ENO2 PNKD

MGI Mouse Phenotypes related to Hemiplegia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 ADCY5 ATP1A2 ATP1A3 CACNA1A COL4A1 ENO2
2 homeostasis/metabolism MP:0005376 10.16 ADCY5 ATP1A2 ATP1A3 BGLAP CACNA1A COL4A1
3 nervous system MP:0003631 9.77 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 EDN1
4 muscle MP:0005369 9.76 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 EDN1
5 respiratory system MP:0005388 9.28 ATP1A2 ATP1A3 CACNA1A COL4A1 COL4A2 ENO2
Sources

Drugs & Therapeutics for Hemiplegia

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Drugs for Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Succinylcholine Approved Phase 4 306-40-1 5314
2
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
3
Baclofen Approved Phase 4 1134-47-0 2284
4 Gastrodia Phase 4
5 Neuromuscular Blocking Agents Phase 4
6 Cholinergic Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Botulinum Toxins Phase 4
9 abobotulinumtoxinA Phase 4
10 Botulinum Toxins, Type A Phase 4
11 GABA Agonists Phase 4
12 rimabotulinumtoxinB Phase 2, Phase 3
13
Glycerol Approved, Investigational Phase 2 56-81-5 753
14
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
15
Sodium oxybate Approved Phase 1, Phase 2 502-85-2 5360545
16
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
17
Nimodipine Approved, Investigational Phase 1, Phase 2 66085-59-4 4497
18 Carbon Fiber Phase 1, Phase 2
19 Anesthetics, General Phase 1, Phase 2
20 Anesthetics, Intravenous Phase 1, Phase 2
21 Hormones Phase 2
22 Hormone Antagonists Phase 2
23 glucocorticoids Phase 2
24 Anti-Inflammatory Agents Phase 2
25 Sodium Channel Blockers Phase 2
26 Anti-Arrhythmia Agents Phase 2
27 Diuretics, Potassium Sparing Phase 2
28 Anesthetics, Local Phase 2
29 Immunologic Factors Phase 2
30 Triamcinolone diacetate Phase 2
31 Immunosuppressive Agents Phase 2
32 triamcinolone acetonide Phase 2
33 Triamcinolone hexacetonide Phase 2
34 Passionflower Phase 1, Phase 2
35
Sodium citrate Approved, Investigational Phase 1 68-04-2
36
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
37 Anesthetics Phase 1
38 Citrate Phase 1
39 Phosphodiesterase 5 Inhibitors Phase 1
40 Phosphodiesterase Inhibitors Phase 1
41 Vasodilator Agents Phase 1
42 Sildenafil Citrate Phase 1 171599-83-0
43
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
44
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
45 Raspberry Approved
46
Methamphetamine Approved, Illicit 537-46-2 10836
47
Dopamine Approved 51-61-6, 62-31-7 681
48
Tranexamic Acid Approved 1197-18-8 5526
49 Coconut Approved
50
Ondansetron Approved 99614-02-5 4595

Interventional clinical trials:

(show top 50) (show all 350)
# Name Status NCT ID Phase Drugs
1 Functional Electrical Stimulation (FES)-Assisted Walking: Enhancement of Voluntary Walking Function Among Persons With Severe Hemiplegia Post-Stroke Unknown status NCT00552916 Phase 4
2 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
3 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
4 Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing the Antispastic Efficacy and Safety of Dynamic Night Hand Splinting in Adults With Post-stroke Hemiplegia Treated by Botulimum Toxin (Dysport®) - (a Pilot Study) Unknown status NCT02888548 Phase 4
5 Multi-center, Single Arm, Open-label, Phase IV Clinical Trial to Evaluate the Safety and Efficacy of MEDITOXIN® in Children With Cerebral Palsy Completed NCT01256021 Phase 4 Botulinum Toxin Type A
6 Characterizing Fade Upon Train-of Four Stimulation During Onset and Offset of Neuromuscular Block Produced by Succinlycholine Completed NCT02425449 Phase 4 Succinylcholine
7 Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen. Recruiting NCT02462317 Phase 4 botulinum A toxin;Baclofen;Placebo toxin;placebo baclofen
8 Research Assistant Doctor Not yet recruiting NCT03860662 Phase 4 Botox;Baclofen
9 Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
10 Comparison of Surface Landmark, Ultrasonography and Electric Stimulation Guidance for Botulinum Toxin Injections in Stroke Patients With Spasticity on Upper Extremities. Unknown status NCT02557737 Phase 3 Botulinum Toxin Type A
11 Modulation of Brain Plasticity After Perinatal Stroke: The PLASTIC CHAMPS Trial Unknown status NCT01189058 Phase 2, Phase 3
12 Double-blinded, Randomized, Active Control Comparative, Multicenter-designed, Phase III Clinical Trial to Evaluate the Safety and Efficacy of "Botulax®" Versus "Botox®" in Children With Cerebral Palsy Completed NCT01787344 Phase 3 Botulinum Toxin Type A(Botox®);Botulinum toxin type A(Botulax®)
13 Assisted Movement Neuro-rehabilitation: VA Multi-site Clinical Trial Completed NCT00223808 Phase 3
14 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
15 Transcranial Direct Current Stimulation and Robotic Training in Chronic Stroke Completed NCT03562663 Phase 3
16 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
17 Combined Inspiratory and Expiratory Muscle Training in Long-term Stroke Completed NCT02828943 Phase 3
18 Is it Possible to Improve Static and Dynamic Postural Stability in Cerebral Palsy Children by Modulating Attention? Completed NCT01799304 Phase 3
19 Randomised Controlled Trial to Evaluate the Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity (Repeated Botulinum Toxin Injections and Physiotherapy) on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Recruiting NCT02944929 Phase 3
20 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
21 A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity Followed by an Open-Label Extension, Multiple-Treatment Safety Study of MYOBLOC Active, not recruiting NCT04099667 Phase 2, Phase 3 rimabotulinumtoxinB;Placebo
22 Burke-Hocoma Efficiency Study Enrolling by invitation NCT03555825 Phase 3
23 Effects of the Quantity of Repetitive Transcranial Magnetic Stimulation on the Recovery of Upper Motor Function After Stroke: a Randomized Controlled Trial Terminated NCT01311271 Phase 2, Phase 3
24 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
25 Randomized Clinical Trial of Hand Arm Bimanual Intensive Therapy (HABIT) Unknown status NCT01413594 Phase 1, Phase 2
26 Effet de la réadaptation Sur Les déficiences, Limitations d'activité et Restriction de la Participation Des Enfants présentant Des lésions Neurologiques Non-évolutives (Infirmes Moteurs cérébraux). Unknown status NCT01700777 Phase 1, Phase 2
27 Rehabilitation of Early Stroke Patients Using a Custom-made Solid Ankle-foot Orthosis: a Randomised Controlled Trial Unknown status NCT01006772 Phase 1, Phase 2
28 Treating Apoplectic Sequela With Acupuncture: a Randomized Controlled Study Unknown status NCT01003470 Phase 2
29 Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction After Stroke Unknown status NCT01010607 Phase 1, Phase 2
30 Modified Constraint-Induced Movement Therapy and Eye Patching for Neglect Rehabilitation Post Stroke: A Longitudinal Study of Separate and Combined Effects Unknown status NCT00253825 Phase 1, Phase 2
31 Improving Treatment of People With Movement Disorders in the Middle East Unknown status NCT01466296 Phase 2
32 A Phase 2 Study of HC-58 in Patients With Severe Upper Limb Hemiplegia After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
33 "Etude Pilote, Comparative, Monocentrique, randomisée, en Cross Over, en Double Aveugle, Contre Placebo, Testant l'efficacité de l'Huile triheptanoïne Dans Les Hémiplégies Alternantes de l'Enfant" HEMIHEP Completed NCT02408354 Phase 2 Triheptanoin;Placebo
34 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity in the Affected Leg of Hemiplegics Completed NCT01569386 Phase 2
35 Single-center Phase I/II Trial of Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO Trial) Completed NCT00931164 Phase 1, Phase 2 Sodium Oxybate
36 Suprascapular Nerve Block in Hemiplegic Shoulder Pain. Completed NCT00732589 Phase 2 1% xylocaine
37 Contralaterally Controlled Functional Electrical Stimulation for Hemiparetic Hand Completed NCT00565045 Phase 1, Phase 2
38 A Feasibility Trial to Evaluate the MindFrame System in the Recanalization of Occluded Vessels in Patients Experiencing an Ischemic Stroke Completed NCT00810095 Phase 2
39 Robot Assisted Upper Limb Neuro-Rehabilitation Completed NCT00011583 Phase 2
40 Auditory Rhythm Cues + Task Practice: Effects on UE Motor Function Post-stroke Completed NCT00523523 Phase 1, Phase 2
41 The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy Completed NCT00619853 Phase 2
42 Subacute Stroke Recovery (Upper Extremity Motor Function): Bimanual Coordination Training Completed NCT00369668 Phase 2
43 Video-Based Functional Performance and Assessment Following Stroke Completed NCT00013494 Phase 2
44 FNS and Weight Support Treadmill Training for Gait Component Restoration Completed NCT00011596 Phase 2
45 Evaluation of Therapeutic Effects of Navigation-guided 1 Hz rTMS Administered to the Contralesional Hemisphere in Patients With Stroke Completed NCT01049802 Phase 1, Phase 2
46 Clinical Trials in Stroke Rehabilitation Completed NCT00597766 Phase 2 Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine
47 THE IMMEDIATE EFFECT OF ELECTRICAL STIMULATION TRANSCRANIAL DIRECT CURRENT (tDCS) ON CARDIORESPIRATORY PARAMETERS IN HEMIPARETICS ADULTS PATIENTS DUE TO STROKE Completed NCT02398344 Phase 1, Phase 2
48 Randomised Controlled Trial to Compare Two Methods of Constraint Induced Movement Therapy to Improve Functional Ability in the Affected Upper Limb in Pre-school Children With Hemiplegic Cerebral Palsy Completed NCT01770678 Phase 2
49 Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia Enrolling by invitation NCT02987855 Phase 1, Phase 2
50 Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) Not yet recruiting NCT03356821 Phase 1, Phase 2

Search NIH Clinical Center for Hemiplegia

Cochrane evidence based reviews: hemiplegia

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Genetic Tests for Hemiplegia

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Anatomical Context for Hemiplegia

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MalaCards organs/tissues related to Hemiplegia:

40
Brain, Testes, Bone, Cortex, Heart, Spinal Cord, Skin
Sources

Publications for Hemiplegia

About this section

Articles related to Hemiplegia:

(show top 50) (show all 7568)
# Title Authors PMID Year
1
Combined effect of repetitive transcranial magnetic stimulation and physical exercise on cortical plasticity. 61
32394946 2020
2
Molecular genetic and mitochondrial metabolic analyses confirm the suspected mitochondrial etiology in a pediatric patient with an atypical form of alternating hemiplegia of childhood. 61
32489883 2020
3
Long-term follow-up and novel genotype-phenotype analysis of monozygotic twins with ATP1A3 mutation in Alternating Hemiplegia of Childhood-2. 61
32454213 2020
4
Evaluation of the bilateral function in para-athletes with spastic hemiplegia: A model-based clustering approach. 61
31956044 2020
5
Mutational and phenotypic expansion of ATP1A3-related disorders: Report of nine cases. 61
32339621 2020
6
Neuronal modeling of alternating hemiplegia of childhood reveals transcriptional compensation and replicates a trigger-induced phenotype. 61
32348881 2020
7
Social impairments in alternating hemiplegia of childhood. 61
32031250 2020
8
Short-term effect of a close-fitting type of walking assistive device on spinal cord reciprocal inhibition. 61
32386864 2020
9
Delayed Intracranial Parenchymal Changes After Aneurysmal Coil Embolization Procedures for Unruptured Intracranial Aneurysms. 61
31584072 2020
10
Supraclinoid Internal Carotid Artery Aneurysm Clipping Complicated by Aneurysm Dome Origin of the Anterior Choroidal Artery: 2-Dimensional Operative Video. 61
32147728 2020
11
Effects of high-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex on motor recovery in severe hemiplegic stroke: A randomized clinical trial. 61
32380449 2020
12
Fatal Penetrating Head Injuries Caused by Projectile Tear Gas Canisters. 61
32081822 2020
13
Trousseau syndrome with intrahepatic cholangiocarcinoma that could be removed radically after endovascular treatment: Report of a case. 61
32506690 2020
14
Ketamine Infusion for Super Refractory Status Epilepticus in Alternating Hemiplegia of Childhood. 61
32016945 2020
15
Cell biology and dynamics of Neuronal Na+/K+-ATPase in health and diseases. 61
30550795 2020
16
[Successful Total Resection with Preceding Arterial Coil Embolization of Intradural Extramedullary Tumor at Craniovertebral Junction Encasing Dominant-side Vertebral Artery]. 61
32572002 2020
17
Sarcopenia in Hemiplegia. 61
32510029 2020
18
The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage. 61
32552090 2020
19
Ischemic stroke associated with novel coronavirus 2019: a report of three cases. 61
32543260 2020
20
Stanford type a aortic dissection with cerebral infarction: a rare case report. 61
32576285 2020
21
Successful endovascular therapy for cerebral venous sinus thrombosis accompanied by heparin-induced thrombocytopenia. 61
32114865 2020
22
Home-Based Functional Electrical Stimulation-Assisted Hand Therapy Video Games for Children With Hemiplegia: Development and Proof-of-Concept. 61
32396095 2020
23
[Influence of acupuncture combined with rehabilitation therapy on limb motor function and serum cAMP and cGMP in patients with hemiplegia of cerebral ischemic stroke]. 61
32538005 2020
24
Effects of innovative hip-knee-ankle interlimb coordinated robot training on ambulation, cardiopulmonary function, depression, and fall confidence in acute hemiplegia. 61
32538882 2020
25
Two cases of posterior cerebral artery P2 occlusion with motor weakness improved by acute mechanical thrombectomy. 61
32562904 2020
26
Acrophialophora levis brain abscess in a kidney transplant patient: A case report and review of the literature. 61
32257779 2020
27
Pituitary Apoplexy Leading to Cerebral Infarction: A Systematic Review. 61
32544913 2020
28
Efficacy of functional magnetic stimulation in improving upper extremity function after stroke: a randomized, single-blind, controlled study. 61
32495667 2020
29
Combination of pregabalin and transcutaneous electrical nerve stimulation for neuropathic pain in a stroke patient after contralateral C7 nerve transfer: A case report. 61
32576077 2020
30
Segmental body composition transitions in stroke patients: Trunks are different from extremities and strokes are as important as hemiparesis. 61
31522786 2020
31
Does the right or left hemisphere involvement affect the swallowing in patients with hemiplegia? 61
32538883 2020
32
Aspergillus and Rhizopus Fungal Coinfection in a Patient With Multiple Myeloma. 61
32537269 2020
33
The Extra Mile: Special Consideration of Atrial Fibrillation in Older Adults with Endurance Athletic History. 61
32451372 2020
34
Headache in children with Sturge-Weber syndrome - Prevalence, associations and impact. 61
32561288 2020
35
Reinvestigation of the origins of pineal meningiomas based on its related veins and arachnoid membranes. 61
32434477 2020
36
Endovascular Hyaluronidase Application Through Superselective Angiography to Rescue Blindness Caused by Hyaluronic Acid Injection. 61
32401308 2020
37
Opalski Syndrome Treated with Intravenous Recombinant Tissue Type Plasminogen Activator-Case Report and Review of Literature. 61
32434729 2020
38
Genetically confirmed CARASIL: A case report with a novel HTRA1 mutation and literature review. 61
32445900 2020
39
Eye-acupuncture with rehabilitation therapy for stroke. 61
32358398 2020
40
Magnetic resonance imaging volumetric analysis in patients with Alternating hemiplegia of childhood: A pilot study. 61
32115366 2020
41
Hemiconvulsion-Hemiplegia-Epilepsy Syndrome in Adult with Uncontrolled Seizures and Phenytoin Toxicity. 61
32499971 2020
42
Brain volumetrics in alternating hemiplegia of childhood. 61
32376083 2020
43
White matter and cerebellar involvement in alternating hemiplegia of childhood. 61
31950366 2020
44
A case of myelin oligodendrocyte glycoprotein-antibody-associated disease presenting with tumefactive demyelinating lesion. 61
32474283 2020
45
Immediate effect of induced fatigue of the unaffected limb on standing balance, proprioception and vestibular symptoms in children with hemiplegia. 61
32444572 2020
46
Effects of nutritional status on prognosis in patients with severe hemiplegia who were recently admitted to a rehabilitation hospital. 61
32425348 2020
47
Cardiac Myxoma as a Rare Cause of Pediatric Arterial Ischemic Stroke: Case Report and Literature Review. 61
32369836 2020
48
A Retrospective Analysis of Factors Impacting Rehabilitation Outcomes in Patients with Spontaneous Intracerebral Hemorrhage. 61
32371627 2020
49
The Core Knowledge and Skills of Nursing Competency Regarding Mealtime Assistance for Hemiplegic Patients in China. 61
32335318 2020
50
The effects of hemiplegic shoulder pain on upper extremity motor function and proprioception. 61
32508338 2020
Sources

Variations for Hemiplegia

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ClinVar genetic disease variations for Hemiplegia:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ATP1A3 NM_152296.5(ATP1A3):c.2443G>A (p.Glu815Lys)SNV Pathogenic 37108 rs387907281 19:42474436-42474436 19:41970284-41970284
2 ATP1A3 NM_152296.5(ATP1A3):c.2839G>A (p.Gly947Arg)SNV Pathogenic 37110 rs398122887 19:42471896-42471896 19:41967744-41967744
3 ATP1A3 NM_152296.5(ATP1A3):c.958G>C (p.Ala320Pro)SNV Likely pathogenic 523558 rs879255368 19:42489105-42489105 19:41984953-41984953
4 MYH6 NM_002471.4(MYH6):c.3195G>C (p.Gln1065His)SNV Conflicting interpretations of pathogenicity 14149 rs267606904 14:23862177-23862177 14:23392968-23392968
5 DSP NM_004415.4(DSP):c.5218G>A (p.Glu1740Lys)SNV Conflicting interpretations of pathogenicity 44926 rs142885240 6:7581641-7581641 6:7581408-7581408
6 MYH6 NM_002471.3(MYH6):c.4594C>T (p.Arg1532Cys)SNV Conflicting interpretations of pathogenicity 239175 rs201827489 14:23856794-23856794 14:23387585-23387585
7 SCN5A NM_000335.5(SCN5A):c.892G>A (p.Gly298Ser)SNV Uncertain significance 9387 rs137854608 3:38651267-38651267 3:38609776-38609776
Sources

Expression for Hemiplegia

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Search GEO for disease gene expression data for Hemiplegia.
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Pathways for Hemiplegia

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Pathways related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 36
Show member pathways
 12.74 SLC2A1 EDN1 ATP1A3 ATP1A2 ADCY5
2
Circadian entrainment 36
Show member pathways
 12.58 SLC1A3 SLC1A1 SCN1A CACNA1A ADCY5
3
Collagen chain trimerization 65
Show member pathways
 12.52 SLC1A1 MMP9 COL4A2 COL4A1 ATP1A3 ATP1A2
4
Relaxin signaling pathway 36
Show member pathways
 12.43 MMP9 EDN1 COL4A2 COL4A1 ADCY5
5
Neuropathic Pain-Signaling in Dorsal Horn Neurons 63
Show member pathways
 12.39 TAC1 SCN1A ATP1A3 ATP1A2 ADCY5
6
Pathways in cancer 36
12.36 SLC2A1 MMP9 EDN1 COL4A2 COL4A1 ADCY5
7
cAMP signaling pathway 36
12.13 EDN1 ATP1A3 ATP1A2 ADCY5
8
Synaptic vesicle cycle 36
Show member pathways
 11.78 SLC1A3 SLC1A1 CACNA1A ATP1A2
9
Pancreatic secretion 36
11.74 ATP1A3 ATP1A2 ADCY5
10
AGE-RAGE signaling pathway in diabetic complications 36
11.72 EDN1 COL4A2 COL4A1
11
Cardiac muscle contraction 36
11.65 MYH6 ATP1A3 ATP1A2
12
Thyroid hormone signaling pathway 36
11.64 SLC2A1 MYH6 ATP1A3 ATP1A2
13
Neuroscience 4
11.63 SLC1A3 SLC1A1 SCN1A S100B ENO2 CALCA
14
Neural Stem Cells and Lineage-specific Markers 64
11.6 SLC2A1 SLC1A3 S100B
15
Lung fibrosis 1
11.45 MMP9 EDN1 CALCA
16
Cell adhesion_ECM remodeling 22
11.42 MMP9 COL4A2 COL4A1
17
Bile secretion 36
11.21 SLC2A1 ATP1A3 ATP1A2 ADCY5
Sources

GO Terms for Hemiplegia

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Cellular components related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.88 TAC1 SLC1A3 SLC1A1 CACNA1A ATP1A3 ATP1A2
2 cell GO:0005623 9.8 TAC1 EDN1 CALCA CACNA1A ATP1A3 ATP1A2
3 axon GO:0030424 9.72 TAC1 SLC1A1 SCN1A CALCA ATP1A3
4 extracellular space GO:0005615 9.61 TAC1 S100B MMP9 ENO2 EDN1 COL4A2
5 sodium:potassium-exchanging ATPase complex GO:0005890 9.43 ATP1A3 ATP1A2
6 collagen type IV trimer GO:0005587 9.37 COL4A2 COL4A1
7 intercalated disc GO:0014704 9.33 SLC2A1 SCN1A ATP1A2
8 neuronal cell body GO:0043025 9.32 TAC1 SLC1A3 SLC1A1 SCN1A S100B ENO2

Biological processes related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.97 SLC1A3 SLC1A1 SCN1A CACNA1A ATP1A3 ATP1A2
2 ion transmembrane transport GO:0034220 9.93 SCN1A CACNA1A ATP1A3 ATP1A2
3 chemical synaptic transmission GO:0007268 9.87 TAC1 SLC1A3 SLC1A1 CACNA1A
4 neuromuscular process controlling balance GO:0050885 9.65 SLC1A3 CACNA1A ADCY5
5 L-glutamate transmembrane transport GO:0015813 9.63 SLC1A3 SLC1A1
6 response to activity GO:0014823 9.63 EDN1 COL4A2 BGLAP
7 response to amyloid-beta GO:1904645 9.62 MMP9 CACNA1A
8 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.62 ATP1A3 ATP1A2
9 sodium ion export across plasma membrane GO:0036376 9.61 ATP1A3 ATP1A2
10 positive regulation of renal sodium excretion GO:0035815 9.61 TAC1 EDN1
11 cellular potassium ion homeostasis GO:0030007 9.6 ATP1A3 ATP1A2
12 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.59 ATP1A3 ATP1A2
13 neurotransmitter uptake GO:0001504 9.58 SLC1A3 ATP1A2
14 cellular response to steroid hormone stimulus GO:0071383 9.58 ATP1A3 ATP1A2
15 neuromuscular process controlling posture GO:0050884 9.56 SCN1A PNKD
16 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.55 COL4A2 COL4A1
17 transepithelial transport GO:0070633 9.54 SLC1A3 SLC1A1
18 regulation of glucose transmembrane transport GO:0010827 9.52 SLC2A1 EDN1
19 L-glutamate import across plasma membrane GO:0098712 9.51 SLC1A3 SLC1A1
20 response to glycoside GO:1903416 9.43 ATP1A3 ATP1A2
21 blood vessel morphogenesis GO:0048514 9.43 SLC1A1 EDN1 COL4A1
22 L-aspartate import across plasma membrane GO:0140009 9.4 SLC1A3 SLC1A1
23 D-aspartate import across plasma membrane GO:0070779 9.37 SLC1A3 SLC1A1
24 positive regulation of cytosolic calcium ion concentration GO:0007204 9.35 TAC1 EDN1 CALCA CACNA1A ADCY5
25 response to pain GO:0048265 9.33 TAC1 CALCA CACNA1A
26 L-glutamate import GO:0051938 9.32 SLC1A3 SLC1A1
27 regulation of blood pressure GO:0008217 9.02 TAC1 MYH6 EDN1 CALCA ATP1A2

Molecular functions related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.73 SLC1A3 SLC1A1 S100B RNF213 PNKD MMP9
2 L-glutamate transmembrane transporter activity GO:0005313 9.43 SLC1A3 SLC1A1
3 glutamate binding GO:0016595 9.4 SLC1A3 SLC1A1
4 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP1A3 ATP1A2
5 potassium-transporting ATPase activity GO:0008556 9.32 ATP1A3 ATP1A2
6 steroid hormone binding GO:1990239 9.26 ATP1A3 ATP1A2
7 high-affinity glutamate transmembrane transporter activity GO:0005314 9.16 SLC1A3 SLC1A1
8 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A3 SLC1A1
Sources

Sources for Hemiplegia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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