Aliases & Classifications for Hemiplegia

MalaCards integrated aliases for Hemiplegia:

Name: Hemiplegia 12 76 53 29 6 44 15
Postnatal Infantile Hemiplegia 12
Hemiplegia, Infantile 73
Infantile Hemiplegia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10969
ICD9CM 35 343.4
MeSH 44 D006429
ICD10 33 G81 G81.9
UMLS 73 C0392550

Summaries for Hemiplegia

MalaCards based summary : Hemiplegia, also known as postnatal infantile hemiplegia, is related to porencephaly 1 and familial porencephaly. An important gene associated with Hemiplegia is ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3), and among its related pathways/superpathways are G-Beta Gamma Signaling and Vascular smooth muscle contraction. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 Hemiparesis, or unilateral paresis, is weakness of one entire side of the body (hemi- means \"half\").... more...

Related Diseases for Hemiplegia

Diseases related to Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 porencephaly 1 33.4 COL4A1 COL4A2
2 familial porencephaly 32.8 COL4A1 COL4A2
3 porencephaly 32.5 COL4A1 COL4A2
4 episodic ataxia 32.4 ATP1A2 CACNA1A SLC1A3
5 episodic ataxia, type 6 32.0 CACNA1A SLC1A3
6 moyamoya disease 1 32.0 ACTA2 GUCY1A1 RNF213
7 familial hemiplegic migraine 30.3 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A
8 alternating hemiplegia of childhood 29.8 ADCY5 ATP1A2 ATP1A3 CACNA1A CALCA SLC1A3
9 hemiplegic migraine 29.6 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A SLC2A1
10 headache 28.7 ATP1A2 CACNA1A SCN1A TAC1
11 spastic hemiplegia 12.5
12 alternating hemiplegia of childhood 2 12.3
13 alternating hemiplegia of childhood 1 12.2
14 idiopathic hemiconvulsion-hemiplegia syndrome 12.1
15 hemiplegia alterans 12.1
16 benign nocturnal alternating hemiplegia of childhood 12.0
17 epileptic hemiplegia 12.0
18 weber syndrome 11.3
19 medial medullary syndrome 11.0
20 porencephaly 2 10.9
21 brown-sequard syndrome 10.9
22 moyamoya disease 2 10.8
23 moyamoya disease 5 10.8
24 moyamoya disease 6 with achalasia 10.8
25 childhood-onset cerebral x-linked adrenoleukodystrophy 10.8
26 spastic cerebral palsy 10.8
27 angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 10.7 COL4A1 COL4A2
28 spasticity 10.6
29 anosognosia 10.4
30 oculogyric crisis 10.4 ATP1A3 SLC2A1
31 epilepsy 10.4
32 cerebritis 10.3
33 cerebral arterial disease 10.2 ACTA2 GUCY1A1 RNF213
34 myoclonic astatic epilepsy 10.2 SCN1A SLC2A1
35 laryngitis 10.2
36 herpes zoster 10.1
37 herpes zoster ophthalmicus 10.1
38 familial or sporadic hemiplegic migraine 10.1 ATP1A2 CACNA1A SCN1A
39 sporadic hemiplegic migraine 10.1 ATP1A2 CACNA1A SCN1A
40 aceruloplasminemia 10.1 ATP1A3 CACNA1A SLC2A1
41 cluster headache 10.0 CACNA1A CALCA
42 migraine without aura 10.0 ATP1A2 CACNA1A SCN1A
43 migraine with aura 10.0 ATP1A2 CACNA1A SCN1A
44 cerebral palsy 10.0
45 dystonia 10.0
46 seizure disorder 10.0 ATP1A3 SCN1A SLC2A1
47 burn scar 9.9 CALCA TAC1
48 stroke, ischemic 9.9
49 reflex sympathetic dystrophy 9.9
50 brain injury 9.9

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to Hemiplegia

Symptoms & Phenotypes for Hemiplegia

UMLS symptoms related to Hemiplegia:


hemiplegia

MGI Mouse Phenotypes related to Hemiplegia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 RNF213 SCN1A ADCY5 ATP1A2 SLC1A3 SLC2A1
2 cardiovascular system MP:0005385 9.86 RNF213 ACTA2 SCN1A ATP1A2 TAC1 COL4A1
3 muscle MP:0005369 9.63 GUCY1A1 ACTA2 ATP1A2 ATP1A3 CACNA1A COL4A1
4 nervous system MP:0003631 9.61 SCN1A ATP1A2 SLC1A3 SLC2A1 ATP1A3 CACNA1A
5 respiratory system MP:0005388 9.1 GUCY1A1 SCN1A ATP1A2 ATP1A3 CACNA1A COL4A1

Drugs & Therapeutics for Hemiplegia

Drugs for Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Not Applicable 51-84-3 187
2 abobotulinumtoxinA Phase 4,Phase 3,Not Applicable
3 Botulinum Toxins Phase 4,Phase 3,Not Applicable
4 Botulinum Toxins, Type A Phase 4,Phase 3,Not Applicable
5 Cholinergic Agents Phase 4,Phase 3,Not Applicable
6 Neuromuscular Agents Phase 4,Phase 3
7 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Not Applicable
8 onabotulinumtoxinA Phase 4,Phase 3,Not Applicable
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 incobotulinumtoxinA Phase 4,Not Applicable
11 Gastrodia Nutraceutical Phase 4
12
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
13
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
14
Ticagrelor Approved Phase 3 274693-27-5 9871419
15
Ticlopidine Approved Phase 3 55142-85-3 5472
16
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
17 tannic acid Approved, Nutraceutical Phase 3,Not Applicable
18 Acetylsalicylic acid lysinate Phase 3
19 Analgesics Phase 3,Not Applicable
20 Analgesics, Non-Narcotic Phase 3
21 Anti-Inflammatory Agents Phase 3,Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 3
23 Antipyretics Phase 3
24 Antirheumatic Agents Phase 3
25 Cyclooxygenase Inhibitors Phase 3
26 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Not Applicable
27 Fibrinolytic Agents Phase 3
28 Platelet Aggregation Inhibitors Phase 3
29 Purinergic P2 Receptor Antagonists Phase 3
30 Purinergic P2Y Receptor Antagonists Phase 3
31 lysine Nutraceutical Phase 3
32
Menthol Approved Phase 2,Phase 1,Not Applicable 2216-51-5 16666
33
Sodium oxybate Approved Phase 1, Phase 2 502-85-2 5360545
34
Lidocaine Approved, Vet_approved Phase 2,Not Applicable 137-58-6 3676
35
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
36
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
37
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
38
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
39
Tamoxifen Approved Phase 2 10540-29-1 2733526
40
Glycerol Approved, Investigational Phase 2 56-81-5 753
41 Carbon fiber Phase 1, Phase 2
42 Adjuvants, Anesthesia Phase 1, Phase 2
43 Anesthetics Phase 1, Phase 2,Phase 2,Not Applicable
44 Anesthetics, General Phase 1, Phase 2,Not Applicable
45 Anesthetics, Intravenous Phase 1, Phase 2
46 Central Nervous System Depressants Phase 1, Phase 2,Phase 2,Not Applicable
47 Anesthetics, Local Phase 2,Not Applicable
48 Anti-Arrhythmia Agents Phase 2,Not Applicable
49 Diuretics, Potassium Sparing Phase 2,Not Applicable
50 Sodium Channel Blockers Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 237)
# Name Status NCT ID Phase Drugs
1 Functional Electrical Stimulation (FES) Assisted Walking: Enhancement of Walking Function After Stroke Unknown status NCT00552916 Phase 4
2 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
3 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
4 The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy Unknown status NCT01256021 Phase 4 Botulinum Toxin Type A
5 Τhe Effectiveness of Hydrotherapy Exercises on the Rehabilitation of Hemiplegic Patients Completed NCT01460277 Phase 4
6 Spread And Effectiveness Of Botulinum Neurotoxin A In Spastic Equinus In Cerebral Palsy Completed NCT01276015 Phase 4 Botulinum Toxin Type A
7 Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression Completed NCT02321436 Phase 4 BotulinumtoxinA;Placebo
8 The Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Recruiting NCT02944929 Phase 4
9 Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC) Active, not recruiting NCT02969356 Phase 4 AbobotulinumtoxinA (Dysport®)
10 Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing Dynamic Hand Splinting in Adults With Post-stroke Hemiplegia (Orthox) Not yet recruiting NCT02888548 Phase 4
11 HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
12 Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) Unknown status NCT02817789 Phase 3 Ticagrelor alone;Combination lysine acetylsalicylate - clopidogrel
13 Mental Practice Efficacy in Stroke-Induced Hemiparesis Unknown status NCT01026896 Phase 2, Phase 3
14 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
15 MEOPA to Improve Physical Therapy Results After Multilevel Surgery Completed NCT00632528 Phase 3 MEOPA;Medicinal air
16 Assisted Movement Neuro-rehabilitation: VA Multi-site Clinical Trial Completed NCT00223808 Phase 3
17 Static and Dynamic Postural Stability in Cerebral Palsy Children Completed NCT01799304 Phase 3
18 Phase III Clinical Trial of "Botulax®" to Treat Children With Cerebral Palsy Completed NCT01787344 Phase 3 Botulinum Toxin Type A(Botox®);Botulinum toxin type A(Botulax®)
19 Home Based Adaptive Arm Training for Children Recruiting NCT02751502 Phase 3
20 Ventilatory Muscle Training in Stroke Recruiting NCT02828943 Phase 3
21 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
22 iMRI Guided Resection in Cerebral Glioma Surgery Recruiting NCT01479686 Phase 3
23 Burke-Hocoma Efficiency Study Enrolling by invitation NCT03555825 Phase 3
24 Effects of the Quantity of Repetitive Transcranial Magnetic Stimulation(rTMS) on the Recovery After Stroke Terminated NCT01311271 Phase 2, Phase 3
25 Bimanual Training in Children With Hemiplegia Unknown status NCT01413594 Phase 1, Phase 2
26 Bimanual Training in Children With Hemiplegia With Lower Limb and Postural Stimulation (HABIT & Leg) Unknown status NCT01700777 Phase 1, Phase 2
27 Rehabilitation of Early Stroke Patients Using an AFO: an RCT Unknown status NCT01006772 Phase 1, Phase 2
28 Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction Unknown status NCT01010607 Phase 1, Phase 2
29 The Middle East "Stepping Forward" Project (MESF) Unknown status NCT01466296 Phase 2
30 mCIMT and Eye Patching for Neglect Rehabilitation Post Stroke: A Longitudinal Study of Separate and Combined Effects Unknown status NCT00253825 Phase 1, Phase 2
31 Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO) Completed NCT00931164 Phase 1, Phase 2 Sodium Oxybate
32 Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
33 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity of Hemiplegics Completed NCT01569386 Phase 2
34 Training the Arm and Hand After Stroke Using Auditory Rhythm Cues Completed NCT00523523 Phase 1, Phase 2
35 Post Stroke Hand Functions: Bilateral Movements and Electrical Stimulation Treatments Completed NCT00369668 Phase 2
36 Contrastim Stroke Trial Completed NCT01049802 Phase 1, Phase 2
37 Treatments for Recovery of Hand Function in Acute Stroke Survivors Completed NCT00565045 Phase 1, Phase 2
38 FNS and Weight Support Treadmill Training for Gait Component Restoration Completed NCT00011596 Phase 2
39 The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy Completed NCT00619853 Phase 2
40 SSNB in Hemiplegic Shoulder Pain Completed NCT00732589 Phase 2 1% xylocaine
41 Robot Assisted Upper Limb Neuro-Rehabilitation Completed NCT00011583 Phase 2
42 A Trial Comparing Two Methods of CIMT in the Hemiplegic Child Completed NCT01770678 Phase 2
43 Subacromial Corticosteroid Injection for Hemiplegic Shoulder Pain Completed NCT00597766 Phase 2 Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine;Triamcinolone + Lidocaine
44 Video-Based Functional Performance and Assessment Following Stroke Completed NCT00013494 Phase 2
45 Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study Completed NCT00810095 Phase 2
46 Safety Escalating Repeat IV, in Stroke Patients Completed NCT00833989 Phase 2 GSK249320;PLACEBO
47 E-Rehabilitation: Aerobic Resistance Training for Stroke Survivors Recruiting NCT02938000 Phase 1, Phase 2
48 Treatment With Tamoxifen in Cryptococcal Meningitis Recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
49 Pilot Study, Comparative, Single-center, Randomized, Crossover, Double-blind, Against Placebo, Testing the Effectiveness of Triheptanoin Oil in Alternating Hemiplegia of Childhood Active, not recruiting NCT02408354 Phase 2 Triheptanoin;Placebo
50 Passive Mobilisation of Region of Shoulder Joints for Hemiplegic Patient Not yet recruiting NCT02904148 Phase 2

Search NIH Clinical Center for Hemiplegia

Cochrane evidence based reviews: hemiplegia

Genetic Tests for Hemiplegia

Genetic tests related to Hemiplegia:

# Genetic test Affiliating Genes
1 Hemiplegia 29

Anatomical Context for Hemiplegia

MalaCards organs/tissues related to Hemiplegia:

41
Brain, Testes, Bone, Eye, Cortex, Skin, Spinal Cord

Publications for Hemiplegia

Articles related to Hemiplegia:

(show top 50) (show all 842)
# Title Authors Year
1
Feasibility of Synergy-Based Exoskeleton Robot Control in Hemiplegia. ( 29877848 )
2018
2
Robotically-driven orthoses exert proximal-to-distal differential recovery on the lower limbs in children with hemiplegia, early after acquired brain injury. ( 29650492 )
2018
3
Clinical aspects, neuroimaging, and electroencephalography of 35 cases of hemiconvulsion-hemiplegia syndrome. ( 29414550 )
2018
4
Hemiconvulsion Hemiplegia Syndrome in a young boy with developmental delay. ( 29808062 )
2018
5
Dynamic Analysis of the Abnormal Isometric Strength Movement Pattern between Shoulder and Elbow Joint in Patients with Hemiplegia. ( 29610654 )
2018
6
Hemiplegia and bilateral globus pallidus infarcts after carbon monoxide poisoning: case report. ( 29571238 )
2018
7
Atrial myxoma with hemiplegia. ( 29474708 )
2018
8
A Seizure and Hemiplegia following Contrast Exposure: Understanding Contrast-Induced Encephalopathy. ( 29686712 )
2018
9
An episode of acute encephalopathy with biphasic seizures and late reduced diffusion followed by hemiplegia and intractable epilepsy observed in a patient with a novel frameshift mutation in HNRNPU. ( 29858110 )
2018
10
Effects of gait training with non-paretic knee immobilization on patients with hemiplegia: Three single-case studies. ( 29469599 )
2018
11
Long-term follow up of an adult with alternating hemiplegia of childhood and a p.Gly755Ser mutation in the ATP1A3 gene. ( 29269014 )
2018
12
Hemiconvulsion-hemiplegia-epilepsy evolving to contralateral hemi-Lennox-Gastaut-like phenotype. ( 29459061 )
2018
13
Development of an item list to assess bilateral upper extremity function of stroke patients with hemiplegia. ( 29400669 )
2018
14
Structural analysis of a rehabilitative training system based on a ceiling rail for safety of hemiplegia patients. ( 29710754 )
2018
15
Pial arteriovenous fistula of the spine in a child with hemiplegia. ( 29881582 )
2018
16
Different impact of prism adaptation rehabilitation in spatial neglect and anosognosia for hemiplegia. ( 29357315 )
2018
17
A walk after hemiplegia. ( 29589055 )
2018
18
Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood. ( 29567111 )
2018
19
Kinesiophobia after complex regional pain syndrome type one in a case of stroke hemiplegia and effect of cognitive behavior therapy. ( 29736085 )
2018
20
Pearls & Oy-sters: Alternating hemiplegia of childhood mimics focal epilepsy and paroxysmal dyskinesia in infancy. ( 29967203 )
2018
21
Rewiring to Regain Function in Patients with Spastic Hemiplegia. ( 29261362 )
2018
22
The effect and biomechanical mechanisms of intradermal needle for post-stroke hemiplegia recovery: Study protocol for a randomized controlled pilot trial. ( 29668611 )
2018
23
The Timed 180A^ Turn Test for Assessing People with Hemiplegia from Chronic Stroke. ( 29568774 )
2018
24
Effect of sensory and motor connectivity on hand function in pediatric hemiplegia. ( 29034483 )
2017
25
REACH: study protocol of a randomised trial of rehabilitation very early in congenital hemiplegia. ( 28928195 )
2017
26
Modulating anosognosia for hemiplegia: The role of dangerous actions in emergent awareness. ( 28501758 )
2017
27
Intermittent Hemiplegia in a Boy with Primary Moyamoya Disease: A Case Report from Iran. ( 28698731 )
2017
28
Diagnosis and Treatment of Alternating Hemiplegia of Childhood. ( 28337648 )
2017
29
Action observation facilitates motor cortical activity in patients with stroke and hemiplegia. ( 29031830 )
2017
30
Hemiconvulsion-hemiplegia-epilepsy syndrome in a child with pre-existing cerebral pathology. ( 28652222 )
2017
31
Exercise using a robotic knee orthosis in stroke patients with hemiplegia. ( 29200624 )
2017
32
Topiramate Therapy in Alternating Hemiplegia of Childhood. ( 28502069 )
2017
33
Recurrent Focal Seizures and Transient Hemiparesis: Think About Alternating Hemiplegia of Childhood. ( 29395725 )
2017
34
Alternating Hemiplegia of Childhood: Pharmacological treatment of 30 Italian patients. ( 28249736 )
2017
35
Alternating hemiplegia of childhood and a pathogenic variant of ATP1A3: a case report and pathophysiological considerations. ( 28637637 )
2017
36
Alternating Hemiplegia and Epilepsia Partialis Continua: A new phenotype for a novel compound TBC1D24 mutation. ( 28292732 )
2017
37
Altered effective connectivity of resting state networks by acupuncture stimulation in stroke patients with left hemiplegia: A multivariate granger analysis. ( 29382021 )
2017
38
Effects of weight training time on bone mineral density of patients with secondary osteoporosis after hemiplegia. ( 28450926 )
2017
39
Alternating Hemiplegia of Childhood with Novel Features. ( 28138908 )
2017
40
Dynamic paraspinal muscle impingement causing acute hemiplegia after C1 posterior arch laminectomy: A case report. ( 29390372 )
2017
41
Challenges describing motor profiles in alternating hemiplegia of childhood. ( 28556907 )
2017
42
A randomized, controlled, double-blind, crossover trial of triheptanoin in alternating hemiplegia of childhood. ( 28969699 )
2017
43
Hemiplegia as a presentation of HIV infection in children: A report of 3 cases. ( 29302563 )
2017
44
A Randomized Controlled Study: Effectiveness of Functional Electrical Stimulation on Wrist and Finger Flexor Spasticity in Hemiplegia. ( 28462794 )
2017
45
An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2. ( 28811059 )
2017
46
Ocular Motor Function in Children with Spastic Hemiplegia Evaluated by the Ocular Motor Score. ( 28771056 )
2017
47
Combined therapy using botulinum toxin A and single-joint hybrid assistive limb for upper-limb disability due to spastic hemiplegia. ( 28131185 )
2017
48
Dengue fever triggering hemiconvulsion hemiplegia epilepsy in a child. ( 28488637 )
2017
49
Three consecutive neurotomies in one patient for the treatment of spastic hemiplegia: Spinal, median, and foot toes common flexor. ( 29184718 )
2017
50
Guillain-BarrAc Syndrome: A Variant Consisting of Facial Diplegia and Paresthesia with Left Facial Hemiplegia Associated with Antibodies to Galactocerebroside and Phosphatidic Acid. ( 28966341 )
2017

Variations for Hemiplegia

ClinVar genetic disease variations for Hemiplegia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh37 Chromosome 19, 42474436: 42474436
2 ATP1A3 NM_152296.4(ATP1A3): c.2443G> A (p.Glu815Lys) single nucleotide variant Pathogenic rs387907281 GRCh38 Chromosome 19, 41970284: 41970284
3 ATP1A3 NM_152296.4(ATP1A3): c.2839G> A (p.Gly947Arg) single nucleotide variant Pathogenic rs398122887 GRCh37 Chromosome 19, 42471896: 42471896
4 ATP1A3 NM_152296.4(ATP1A3): c.2839G> A (p.Gly947Arg) single nucleotide variant Pathogenic rs398122887 GRCh38 Chromosome 19, 41967744: 41967744
5 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh37 Chromosome 14, 23856794: 23856794
6 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh38 Chromosome 14, 23387585: 23387585
7 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh37 Chromosome 19, 42489105: 42489105
8 ATP1A3 NM_152296.4(ATP1A3): c.958G> C (p.Ala320Pro) single nucleotide variant Likely pathogenic rs879255368 GRCh38 Chromosome 19, 41984953: 41984953

Expression for Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for Hemiplegia

Pathways related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 ACTA2 ADCY5 CACNA1A GUCY1A1 SCN1A
2
Show member pathways
12.41 ACTA2 ADCY5 ATP1A2 ATP1A3 GUCY1A1
3
Show member pathways
12.14 ACTA2 ADCY5 CACNA1A CALCA GUCY1A1
4
Show member pathways
12.1 ACTA2 ADCY5 CACNA1A COL4A1 COL4A2 GUCY1A1
5
Show member pathways
12.02 ACTA2 ADCY5 ATP1A2 ATP1A3 SCN1A TAC1
6 11.9 ATP1A3 SLC1A3 TAC1
7
Show member pathways
11.84 ADCY5 ATP1A2 ATP1A3 GUCY1A1
8 11.7 ATP1A2 ATP1A3 SLC2A1
9
Show member pathways
11.67 ATP1A2 CACNA1A SLC1A3
10 11.56 ADCY5 ATP1A2 ATP1A3
11 11.31 ADCY5 ATP1A2 ATP1A3 SLC2A1
12 10.86 ATP1A2 ATP1A3

GO Terms for Hemiplegia

Cellular components related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.62 ATP1A3 CALCA SCN1A TAC1
2 guanylate cyclase complex, soluble GO:0008074 9.37 ADCY5 GUCY1A1
3 sodium:potassium-exchanging ATPase complex GO:0005890 9.26 ATP1A2 ATP1A3
4 collagen type IV trimer GO:0005587 9.16 COL4A1 COL4A2
5 intercalated disc GO:0014704 9.13 ATP1A2 SCN1A SLC2A1
6 neuronal cell body GO:0043025 9.1 ATP1A3 CACNA1A CALCA SCN1A SLC1A3 TAC1

Biological processes related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.91 ATP1A2 ATP1A3 CACNA1A SCN1A SLC1A3
2 aging GO:0007568 9.77 BGLAP CALCA COL4A2
3 sodium ion transport GO:0006814 9.75 ATP1A2 ATP1A3 SCN1A
4 ion transmembrane transport GO:0034220 9.73 ATP1A2 ATP1A3 CACNA1A SCN1A
5 membrane depolarization during action potential GO:0086010 9.62 CACNA1A SCN1A
6 adult walking behavior GO:0007628 9.61 CACNA1A SCN1A
7 ATP hydrolysis coupled proton transport GO:0015991 9.61 ATP1A2 ATP1A3
8 cellular response to amyloid-beta GO:1904646 9.59 ATP1A3 CACNA1A
9 cGMP biosynthetic process GO:0006182 9.58 ADCY5 GUCY1A1
10 cyclic nucleotide biosynthetic process GO:0009190 9.57 ADCY5 GUCY1A1
11 cellular sodium ion homeostasis GO:0006883 9.56 ATP1A2 ATP1A3
12 positive regulation of ossification GO:0045778 9.55 CALCA TAC1
13 cellular potassium ion homeostasis GO:0030007 9.54 ATP1A2 ATP1A3
14 sodium ion export across plasma membrane GO:0036376 9.52 ATP1A2 ATP1A3
15 cellular response to steroid hormone stimulus GO:0071383 9.49 ATP1A2 ATP1A3
16 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.48 ATP1A2 ATP1A3
17 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.46 ATP1A2 ATP1A3
18 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 ADCY5 CACNA1A CALCA TAC1
19 neuromuscular process controlling balance GO:0050885 9.43 ADCY5 CACNA1A SLC1A3
20 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.4 COL4A1 COL4A2
21 response to glycoside GO:1903416 9.37 ATP1A2 ATP1A3
22 neurotransmitter uptake GO:0001504 9.32 ATP1A2 SLC1A3
23 response to pain GO:0048265 9.13 CACNA1A CALCA TAC1
24 regulation of blood pressure GO:0008217 9.02 ACTA2 ATP1A2 CALCA GUCY1A1 TAC1

Molecular functions related to Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorus-oxygen lyase activity GO:0016849 9.32 ADCY5 GUCY1A1
2 adenylate cyclase activity GO:0004016 9.26 ADCY5 GUCY1A1
3 guanylate cyclase activity GO:0004383 9.16 ADCY5 GUCY1A1
4 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP1A2 ATP1A3
5 steroid hormone binding GO:1990239 8.62 ATP1A2 ATP1A3

Sources for Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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