MCID: HMP020
MIFTS: 1

Hemiplegia Alterans

Aliases & Classifications for Hemiplegia Alterans

MalaCards integrated aliases for Hemiplegia Alterans:

Name: Hemiplegia Alterans 54

Summaries for Hemiplegia Alterans

NINDS : 54 Alternating hemiplegia is a rare neurological disorder that develops in childhood, most often before the child is 18 months old. The disorder is characterized by recurrent episodes of paralysis that involve one or both sides of the body, multiple limbs, or a single limb. The paralysis may affect different parts of the body at different times and may be brief or last for several days. Oftentimes these episodes will resolve after sleep. Affected children may also have abnormal movements involving stiffening or "dance-like" movements of a limb, as well as walking and balance problems. Some children have seizures. Children may have normal or delayed development. There are both benign and more serious forms of the disorder. Alternating hemiplegia is primarily caused by mutations in the ATP1A3 gene. Occasionally, a mutation in the ATP1A2 gene is involved in the condition. These genes provide instructions for making very similar proteins. Mutations in these genes reduce the activity of an enzyme called Na+/K+ ATPase, which affects the signals that control muscle movement. However, it not yet clear how the reduced enzyme activity leads to the symptoms of the disorder.

MalaCards based summary : Hemiplegia Alterans

Related Diseases for Hemiplegia Alterans

Symptoms & Phenotypes for Hemiplegia Alterans

Drugs & Therapeutics for Hemiplegia Alterans

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Genetic Tests for Hemiplegia Alterans

Anatomical Context for Hemiplegia Alterans

Publications for Hemiplegia Alterans

Variations for Hemiplegia Alterans

Expression for Hemiplegia Alterans

Search GEO for disease gene expression data for Hemiplegia Alterans.

Pathways for Hemiplegia Alterans

GO Terms for Hemiplegia Alterans

Sources for Hemiplegia Alterans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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