MCID: HMP006
MIFTS: 49

Hemiplegic Migraine

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hemiplegic Migraine

MalaCards integrated aliases for Hemiplegic Migraine:

Name: Hemiplegic Migraine 54 38 74
Migraine Hemiplegic 56

Classifications:



External Ids:

KEGG 38 H00775
UMLS 74 C0270862

Summaries for Hemiplegic Migraine

NIH Rare Diseases : 54 Hemiplegic migraine (HM) is a rare type of migraine with aura that occurs with motor weakness during the aura. There are two types of HM which are distinguished based on the family history: familial hemiplegic migraine (FHM, in which at least one other family member has the condition) and sporadic hemiplegic migraine (SHM, in which there is no family history). Signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. Severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. FHM may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner.

MalaCards based summary : Hemiplegic Migraine, also known as migraine hemiplegic, is related to sporadic hemiplegic migraine and familial or sporadic hemiplegic migraine. An important gene associated with Hemiplegic Migraine is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2), and among its related pathways/superpathways are MAPK signaling pathway and Calcium signaling pathway. The drugs Topiramate and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are Increased viability with SS1P at EC90 and behavior/neurological

Wikipedia : 77 Hemiplegic migraine or Hemiplegic migraine headache is a rare and serious subtype of classical migraine... more...

Related Diseases for Hemiplegic Migraine

Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 1 Migraine, Familial Hemiplegic, 2
Migraine, Familial Hemiplegic, 3 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 sporadic hemiplegic migraine 34.6 ATP1A2 CACNA1A SCN1A
2 familial or sporadic hemiplegic migraine 33.9 ATP1A2 CACNA1A PRRT2 SCN1A
3 familial hemiplegic migraine 33.0 ATP1A2 ATP1A3 CACNA1A CALCA NOTCH3 OPRM1
4 migraine with or without aura 1 32.0 ATP1A2 CACNA1A CALCA NOTCH3 PRRT2 SCN1A
5 episodic ataxia 30.9 ATP1A2 CACNA1A PRRT2
6 aceruloplasminemia 30.6 ATP1A3 CACNA1A SLC2A1
7 epilepsy 30.4 ATP1A2 ATP1A3 CACNA1A PRRT2 SCN1A SLC2A1
8 alternating hemiplegia of childhood 30.3 ATP1A2 ATP1A3 CACNA1A CALCA SLC2A1
9 headache 30.3 ATP1A2 CACNA1A SCN1A
10 hemiplegia 30.3 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A SLC2A1
11 torticollis 30.2 CACNA1A PRRT2
12 migraine with aura 30.1 ATP1A2 CACNA1A NOTCH3 PRRT2 SCN1A
13 dystonia 30.1 ATP1A3 GNB1 PRRT2 SLC2A1
14 migraine, familial hemiplegic, 1 12.5
15 migraine, familial hemiplegic, 2 12.5
16 migraine, familial hemiplegic, 3 12.4
17 alternating hemiplegia of childhood 1 11.4
18 convulsions, familial infantile, with paroxysmal choreoathetosis 11.3
19 alternating hemiplegia of childhood 2 11.3
20 phosphoglycerate kinase deficiency 11.3
21 depression 10.5
22 encephalopathy 10.4
23 generalized epilepsy with febrile seizures plus, type 2 10.3 LOC102724058 SCN1A
24 generalized epilepsy with febrile seizures plus, type 1 10.3 LOC102724058 SCN1A
25 migraine without aura 10.3 ATP1A2 CACNA1A SCN1A
26 episodic ataxia, type 2 10.2
27 spinocerebellar ataxia 6 10.2
28 sturge-weber syndrome 10.2
29 moyamoya disease 1 10.2
30 patent foramen ovale 10.2
31 autosomal dominant cerebellar ataxia 10.2
32 weber syndrome 10.2
33 glut1 deficiency syndrome 2 10.2 PRRT2 SLC2A1
34 paroxysmal choreoathetosis 10.2 PRRT2 SLC2A1
35 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.1
36 cystic fibrosis 10.1
37 retinal degeneration 10.1
38 dystonia, dopa-responsive 10.1 ATP1A3 PRRT2 SLC2A1
39 early onset absence epilepsy 10.1 PRRT2 SLC2A1
40 focal epilepsy 10.0 LOC102724058 SCN1A SLC2A1
41 cluster headache 10.0 CACNA1A CALCA
42 alacrima, achalasia, and mental retardation syndrome 10.0 CACNA1A GNB1 SCN1A SLC2A1
43 pulmonary hypertension, primary, 1 10.0
44 pulmonary arteriovenous fistulas 10.0
45 cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss 10.0
46 orthostatic intolerance 10.0
47 brain injury 10.0
48 traumatic brain injury 10.0
49 crest syndrome 10.0
50 arteriovenous malformation 10.0

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to Hemiplegic Migraine

Symptoms & Phenotypes for Hemiplegic Migraine

GenomeRNAi Phenotypes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with SS1P at EC90 GR00376-A-1 8.8 ATP1A3 GNAI2 GNB1

MGI Mouse Phenotypes related to Hemiplegic Migraine:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ATP1A2 ATP1A3 ATP1B2 CACNA1A GNAI2 GNB1
2 mortality/aging MP:0010768 10.07 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A GNAI2
3 nervous system MP:0003631 9.93 ATP1A2 ATP1A3 ATP1B2 CACNA1A GNAI2 GNB1
4 normal MP:0002873 9.56 ATP1A2 ATP1B1 CACNA1A GNAI2 NOTCH3 OPRM1
5 respiratory system MP:0005388 9.23 ATP1A2 ATP1A3 ATP1B1 CACNA1A GNAI2 GNB1

Drugs & Therapeutics for Hemiplegic Migraine

Drugs for Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 2, Phase 3 97240-79-4 5284627
2 Hypoglycemic Agents Phase 2, Phase 3
3 Anticonvulsants Phase 2, Phase 3
4
Nitroglycerin Approved, Investigational Not Applicable 55-63-0 4510
5
Salmon Calcitonin Approved, Investigational Not Applicable 47931-85-1 16129616
6
Pancrelipase Approved, Investigational 53608-75-6
7
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
8
Calcitonin gene-related peptide Investigational Not Applicable 83652-28-2
9 Vasodilator Agents Not Applicable
10 Bone Density Conservation Agents Not Applicable
11 Katacalcin Not Applicable
12 Hormones Not Applicable
13 calcitonin Not Applicable
14 Calcium, Dietary Not Applicable
15 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00131443 Phase 2, Phase 3 Topiramate
2 A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00158002 Phase 2 Topiramate
3 Continuous Treatment Study of Topiramate in Migraine Participants Completed NCT01799590 Phase 2 Topiramate
4 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Completed NCT00541736 Not Applicable Nitroglycerine
5 Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. Completed NCT00358839 Not Applicable CGRP
6 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 Completed NCT00257985 Not Applicable GTN
7 Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA) Completed NCT00687947 Not Applicable CGRP
8 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
9 Pilot Study of Acute Stroke Using the Brainpulse™ Recruiting NCT03235271

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

Anatomical Context for Hemiplegic Migraine

MalaCards organs/tissues related to Hemiplegic Migraine:

42
Brain, Bone, Testes, Trigeminal Ganglion, Smooth Muscle, Cerebellum, Cortex

Publications for Hemiplegic Migraine

Articles related to Hemiplegic Migraine:

(show top 50) (show all 441)
# Title Authors Year
1
Migrainous Infarction in a Patient With Sporadic Hemiplegic Migraine and Cystic Fibrosis: A 99mTc-HMPAO Brain SPECT Study. ( 30620050 )
2019
2
Familial hemiplegic migraine in a child with seizure disorder: clinical history is the key to diagnosis. ( 30914414 )
2019
3
The Effect of Onabotulinum Toxin on Aura Frequency and Severity in Patients With Hemiplegic Migraine - A Comment. ( 30575970 )
2019
4
The Effect of OnabotulinumtoxinA on Aura Frequency and Severity in Patients With Hemiplegic Migraine: Case Series of 11 Patients. ( 29762872 )
2018
5
A Novel ATP1A2 Gene Variant Associated With Pure Sporadic Hemiplegic Migraine Improved After Patent Foramen Ovale Closure: A Case Report. ( 29867740 )
2018
6
Ocular Dipping in a Patient With Hemiplegic Migraine. ( 29384561 )
2018
7
The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families. ( 29486580 )
2018
8
Pediatric sporadic hemiplegic migraine (ATP1A2 gene): a case report and brief literature review. ( 29904856 )
2018
9
Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation. ( 29343472 )
2018
10
Hemiplegic migraine and stroke in Mary Shelley. ( 29553379 )
2018
11
Smooth muscle Ca<sup>2+</sup> sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation. ( 29513112 )
2018
12
Gain of function of sporadic/familial hemiplegic migraine-causing SCN1A mutations: Use of an optimized cDNA. ( 29986598 )
2018
13
Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine. ( 30038559 )
2018
14
Multimodal imaging findings during severe attacks of familial hemiplegic migraine type 2. ( 30097147 )
2018
15
Ultrastructural changes in microvessels in familial hemiplegic migraine with CACNA1A mutation. ( 30148448 )
2018
16
Familial Hemiplegic Migraine Type 3 (FHM3) With an SCN1A Mutation in a Chinese Family: A Case Report. ( 30498473 )
2018
17
Hemiplegic Migraine as the Initial Presentation of Biopsy Positive Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy. ( 30027023 )
2018
18
Neuronal injuries evidenced by transient cortical magnetic resonance enhancement in hemiplegic migraine: A case report. ( 30092648 )
2018
19
Reversible cortical thickening in hemiplegic migraine. ( 28120619 )
2017
20
Ten years of follow-up in a large family with familial hemiplegic migraine type 1: Clinical course and implications for treatment. ( 28856914 )
2017
21
De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report. ( 28593511 )
2017
22
Familial Hemiplegic Migraine With Asymmetric Encephalopathy Secondary to ATP1A2 Mutation: A Case Series. ( 28445178 )
2017
23
The I+2I^2 isoform combination dominates the astrocytic Na(+) /K(+) -ATPase activity and is rendered nonfunctional by the I+2.G301R familial hemiplegic migraine type 2-associated mutation. ( 28787093 )
2017
24
The genetic relationship between epilepsy and hemiplegic migraine. ( 28479855 )
2017
25
Cerebellar Atrophy and Changes in Cytokines Associated with the CACNA1A R583Q Mutation in a Russian Familial Hemiplegic Migraine Type 1 Family. ( 28900389 )
2017
26
Two novel families with hemiplegic migraine caused by recurrent SCN1A mutation p.F1499L. ( 29145747 )
2017
27
Hyperpolarization-activated current Ih in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1. ( 28363781 )
2017
28
Acute Intravenous Calcium Antagonist for Suspected Hemiplegic Migraine - A Case Story. ( 28559833 )
2017
29
Mild Traumatic Brain Injury in a High School Football Player with Familial Hemiplegic Migraine: A Case Report. ( 28918117 )
2017
30
Brain atrophy following hemiplegic migraine attacks. ( 28750589 )
2017
31
First Episode of Hemiplegic Migraine. ( 28601240 )
2017
32
Enhanced susceptibility to cortical spreading depression in two types of Na<sup>+</sup>,K<sup>+</sup>-ATPase I+2 subunit-deficient mice as a model of familial hemiplegic migraine 2. ( 29041816 )
2017
33
Epilepsy in hemiplegic migraine: Genetic mutations and clinical implications. ( 28058944 )
2017
34
Stroke-like attack: first episode of sporadic hemiplegic migraine. ( 28527090 )
2017
35
Identification of the first in Poland CACNA1A gene mutation in familial hemiplegic migraine. Case report. ( 28169007 )
2017
36
Sulcal hyperintensity mimicking subarachnoid hemorrhage in the context of hemiplegic migraine. ( 29236896 )
2017
37
Erratum to: De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report. ( 28702766 )
2017
38
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation. ( 26763045 )
2016
39
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. ( 26911348 )
2016
40
Postoperative Hemiplegic Migraine After a Laparoscopic Cholecystectomy: A Case Report. ( 28045726 )
2016
41
Intermittent Theta Slowings in Contralateral Side of Weakness after Sleep Deprivation on Spot EEG in Sporadic Hemiplegic Migraine. ( 28101483 )
2016
42
A novel SCN1A mutation identified in a Chinese family with familial hemiplegic migraine: A case report. ( 27919014 )
2016
43
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. ( 27346147 )
2016
44
Hemiplegic migraine and late-onset photosensitive epileptic seizures. ( 27406575 )
2016
45
Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1. ( 27314908 )
2016
46
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation. ( 27226003 )
2016
47
A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine. ( 27062528 )
2016
48
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. ( 27354390 )
2016
49
Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack. ( 27155821 )
2016
50
Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report. ( 27790126 )
2016

Variations for Hemiplegic Migraine

Expression for Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for Hemiplegic Migraine

Pathways related to Hemiplegic Migraine according to KEGG:

38
# Name Kegg Source Accession
1 MAPK signaling pathway hsa04010
2 Calcium signaling pathway hsa04020
3 Cardiac muscle contraction hsa04260
4 Synaptic vesicle cycle hsa04721
5 Glutamatergic synapse hsa04724
6 Cholinergic synapse hsa04725
7 GABAergic synapse hsa04727
8 Dopaminergic synapse hsa04728
9 Long-term depression hsa04730

Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNB1 GNG2
2
Show member pathways
13.02 CACNA1A GNAI2 GNB1 GNG2 SCN1A SCN5A
3
Show member pathways
12.98 CACNA1A GNAI2 GNB1 GNG2 OPRM1 SCN1A
4 12.78 GNAI2 GNB1 GNG2 NOTCH3 SLC2A1
5
Show member pathways
12.78 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2 SCN5A
6
Show member pathways
12.77 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
7
Show member pathways
12.69 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
8
Show member pathways
12.56 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
9 12.54 CALCA NOTCH3 OPRM1 SCN1A SCN5A
10
Show member pathways
12.51 CACNA1A GNAI2 GNB1 GNG2 OPRM1
11
Show member pathways
12.47 GNAI2 GNB1 GNG2 OPRM1
12
Show member pathways
12.47 ATP1A2 ATP1A3 ATP1B1 ATP1B2
13 12.31 CACNA1A GNAI2 GNB1 GNG2
14
Show member pathways
12.3 CACNA1A GNAI2 GNB1 GNG2 SLC2A1
15 12.23 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
16
Show member pathways
12.16 GNAI2 GNB1 GNG2 SLC2A1
17
Show member pathways
12.09 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
18 12.07 CALCA GNAI2 GNB1 GNG2
19 12.03 GNAI2 GNB1 GNG2 NOTCH3
20
Show member pathways
11.99 GNAI2 GNB1 GNG2
21
Show member pathways
11.99 ATP1B1 ATP1B2 CACNA1A CALCA GNAI2 GNB1
22
Show member pathways
11.97 ATP1A2 ATP1A3 ATP1B1 ATP1B2
23 11.92 CACNA1A GNAI2 GNB1 GNG2
24 11.84 ATP1A2 ATP1A3 ATP1B1 ATP1B2
25 11.72 ATP1A2 ATP1A3 ATP1B1 ATP1B2
26 11.66 GNAI2 GNB1 GNG2
27 11.64 GNAI2 GNB1 GNG2
28 11.47 ATP1A2 ATP1A3 ATP1B1 ATP1B2
29 11.45 GNAI2 GNB1 GNG2
30 11.42 ATP1A2 ATP1A3 ATP1B1 ATP1B2
31 11.41 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SLC2A1
32 11.35 CACNA1A GNAI2 GNB1 GNG2
33 11.35 ATP1A2 ATP1A3 ATP1B1 ATP1B2
34 11.29 GNAI2 GNB1 GNG2
35 11.19 ATP1A2 ATP1A3 ATP1B1 ATP1B2
36 11.16 ATP1A2 ATP1A3 ATP1B1 ATP1B2 NOTCH3 SLC2A1
37 10.93 GNB1 GNG2
38 10.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
39 10.48 GNB1 GNG2

GO Terms for Hemiplegic Migraine

Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.85 ATP1A3 CALCA OPRM1 PRRT2 SCN1A SCN5A
2 Z disc GO:0030018 9.67 SCN1A SCN5A SLC2A1
3 sarcolemma GO:0042383 9.65 ATP1A2 ATP1B1 OPRM1 SCN5A SLC2A1
4 T-tubule GO:0030315 9.63 ATP1A2 SCN1A SCN5A
5 caveola GO:0005901 9.62 ATP1A2 ATP1B1 SCN5A SLC2A1
6 heterotrimeric G-protein complex GO:0005834 9.61 GNAI2 GNB1 GNG2
7 extracellular vesicle GO:1903561 9.55 ATP1A2 ATP1A3 ATP1B1 GNAI2 GNB1
8 voltage-gated sodium channel complex GO:0001518 9.48 SCN1A SCN5A
9 intercalated disc GO:0014704 9.35 ATP1A2 ATP1B1 SCN1A SCN5A SLC2A1
10 sodium:potassium-exchanging ATPase complex GO:0005890 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
11 plasma membrane GO:0005886 10.25 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.8 ATP1A2 ATP1A3 ATP1B1 ATP1B2
2 sodium ion transport GO:0006814 9.8 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
3 cardiac muscle contraction GO:0060048 9.71 ATP1A2 ATP1B1 SCN5A
4 potassium ion import across plasma membrane GO:1990573 9.71 ATP1A2 ATP1A3 ATP1B1 ATP1B2
5 cellular sodium ion homeostasis GO:0006883 9.67 ATP1A2 ATP1A3 ATP1B1 ATP1B2
6 membrane depolarization GO:0051899 9.64 CACNA1A SCN5A
7 response to pain GO:0048265 9.64 CACNA1A CALCA
8 negative regulation of adenylate cyclase activity GO:0007194 9.63 GNAI2 OPRM1
9 cellular response to prostaglandin E stimulus GO:0071380 9.63 GNB1 GNG2
10 membrane repolarization GO:0086009 9.63 ATP1A2 ATP1B1 ATP1B2
11 cardiac muscle cell action potential involved in contraction GO:0086002 9.62 SCN1A SCN5A
12 membrane depolarization during action potential GO:0086010 9.62 SCN1A SCN5A
13 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.61 GNAI2 GNB1
14 cellular response to steroid hormone stimulus GO:0071383 9.61 ATP1A2 ATP1A3
15 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.61 GNB1 GNG2 OPRM1
16 neuromuscular process controlling posture GO:0050884 9.6 PRRT2 SCN1A
17 regulation of cardiac muscle cell contraction GO:0086004 9.59 ATP1A2 SCN5A
18 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.58 ATP1A2 SCN5A
19 relaxation of cardiac muscle GO:0055119 9.58 ATP1A2 ATP1B1
20 cellular response to catecholamine stimulus GO:0071870 9.57 GNB1 GNG2
21 positive regulation of potassium ion import GO:1903288 9.56 ATP1B1 ATP1B2
22 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.56 ATP1A2 ATP1A3 ATP1B1 ATP1B2
23 positive regulation of potassium ion transmembrane transporter activity GO:1901018 9.55 ATP1B1 ATP1B2
24 positive regulation of sodium ion export across plasma membrane GO:1903278 9.52 ATP1B1 ATP1B2
25 response to glycoside GO:1903416 9.51 ATP1A2 ATP1A3
26 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.46 ATP1A2 ATP1A3 ATP1B1 ATP1B2
27 cellular potassium ion homeostasis GO:0030007 9.26 ATP1A2 ATP1A3 ATP1B1 ATP1B2
28 sodium ion export across plasma membrane GO:0036376 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
29 ion transport GO:0006811 10.02 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A SCN1A

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.58 CACNA1A SCN1A SCN5A
2 voltage-gated sodium channel activity GO:0005248 9.37 SCN1A SCN5A
3 G-protein beta-subunit binding GO:0031681 9.32 GNG2 OPRM1
4 potassium ion binding GO:0030955 9.26 ATP1A2 ATP1B1
5 sodium ion binding GO:0031402 9.16 ATP1A2 ATP1B1
6 steroid hormone binding GO:1990239 8.96 ATP1A2 ATP1A3
7 sodium:potassium-exchanging ATPase activity GO:0005391 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2

Sources for Hemiplegic Migraine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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