MCID: HMP006
MIFTS: 48

Hemiplegic Migraine

Categories: Rare diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Hemiplegic Migraine

MalaCards integrated aliases for Hemiplegic Migraine:

Name: Hemiplegic Migraine 53 73
Migraine Hemiplegic 55

Classifications:



External Ids:

UMLS 73 C0270862

Summaries for Hemiplegic Migraine

NIH Rare Diseases : 53 Hemiplegic migraine (HM) is a rare type of migraine with aura that occurs with motor weakness during the aura. There are two types of HM which are distinguished based on the family history: familial hemiplegic migraine (FHM, in which at least one other family member has the condition) and sporadic hemiplegic migraine (SHM, in which there is no family history). Signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. Severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. FHM may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner.

MalaCards based summary : Hemiplegic Migraine, also known as migraine hemiplegic, is related to sporadic hemiplegic migraine and familial or sporadic hemiplegic migraine. An important gene associated with Hemiplegic Migraine is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. The drugs Topiramate and Neuroprotective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are Increased viability with SS1P at EC90 and behavior/neurological

Related Diseases for Hemiplegic Migraine

Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 1 Migraine, Familial Hemiplegic, 2
Migraine, Familial Hemiplegic, 3 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 sporadic hemiplegic migraine 34.9 ATP1A2 CACNA1A SCN1A
2 familial or sporadic hemiplegic migraine 34.0 ATP1A2 CACNA1A PRRT2 SCN1A
3 familial hemiplegic migraine 32.1 ATP1A2 ATP1A3 CACNA1A CALCA GNAI2 NOTCH3
4 episodic ataxia 31.2 ATP1A2 CACNA1A PRRT2
5 headache 30.6 ATP1A2 CACNA1A SCN1A
6 aceruloplasminemia 30.5 ATP1A3 CACNA1A SLC2A1
7 torticollis 30.4 CACNA1A PRRT2
8 migraine with aura 30.1 ATP1A2 CACNA1A NOTCH3 PRRT2 SCN1A
9 alternating hemiplegia of childhood 29.9 ATP1A2 ATP1A3 CACNA1A CALCA SLC2A1
10 hemiplegia 29.7 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A SLC2A1
11 dystonia 29.4 ATP1A3 GNB1 PRRT2 SLC2A1
12 migraine with or without aura 1 29.2 ATP1A2 ATP1A3 CACNA1A CALCA MGR5 MGR6
13 migraine, familial hemiplegic, 1 12.2
14 migraine, familial hemiplegic, 2 12.2
15 migraine, familial hemiplegic, 3 12.0
16 alternating hemiplegia of childhood 1 11.2
17 convulsions, familial infantile, with paroxysmal choreoathetosis 11.1
18 alternating hemiplegia of childhood 2 11.1
19 phosphoglycerate kinase deficiency 11.1
20 generalized epilepsy with febrile seizures plus, type 2 10.8 LOC102724058 SCN1A
21 generalized epilepsy with febrile seizures plus, type 1 10.6 LOC102724058 SCN1A
22 migraine without aura 10.6 ATP1A2 CACNA1A SCN1A
23 myoclonic astatic epilepsy 10.4 SCN1A SLC2A1
24 cerebritis 10.4
25 glut1 deficiency syndrome 2 10.4 PRRT2 SLC2A1
26 neuronitis 10.4
27 depression 10.4
28 epilepsy 10.4
29 central nervous system disease 10.3 CACNA1A NOTCH3 SCN1A
30 cluster headache 10.3 CACNA1A CALCA
31 ataxia-oculomotor apraxia 3 10.3
32 encephalopathy 10.3
33 paroxysmal choreoathetosis 10.2 PRRT2 SLC2A1
34 dystonia, dopa-responsive 10.2 ATP1A3 PRRT2 SLC2A1
35 early onset absence epilepsy 10.2 PRRT2 SLC2A1
36 spinocerebellar ataxia 6 10.1
37 sturge-weber syndrome 10.1
38 moyamoya disease 1 10.1
39 patent foramen ovale 10.1
40 autosomal dominant cerebellar ataxia 10.1
41 weber syndrome 10.1
42 alacrima, achalasia, and mental retardation syndrome 10.0 CACNA1A GNB1 SLC2A1
43 episodic ataxia, type 2 10.0
44 retinitis 10.0
45 retinal degeneration 10.0
46 meningitis 10.0
47 juvenile retinoschisis 10.0 ATP1A3 ATP1B2
48 epilepsy, idiopathic generalized 9.9 CACNA1A OPRM1 SCN1A SLC2A1
49 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.8
50 hemifacial atrophy, progressive 9.8

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to Hemiplegic Migraine

Symptoms & Phenotypes for Hemiplegic Migraine

GenomeRNAi Phenotypes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with SS1P at EC90 GR00376-A-1 8.8 ATP1A3 GNAI2 GNB1

MGI Mouse Phenotypes related to Hemiplegic Migraine:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 PRRT2 ATP1B2 SCN1A CACNA1A SCN5A GNAI2
2 mortality/aging MP:0010768 10.07 PRKCSH ATP1B1 ATP1B2 SCN1A CACNA1A SCN5A
3 nervous system MP:0003631 9.93 PRRT2 ATP1B2 SCN1A CACNA1A SCN5A GNAI2
4 normal MP:0002873 9.56 ATP1B1 SCN1A CACNA1A SCN5A GNAI2 ATP1A2
5 respiratory system MP:0005388 9.23 SCN1A CACNA1A GNAI2 GNB1 ATP1A2 NOTCH3

Drugs & Therapeutics for Hemiplegic Migraine

Drugs for Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 2, Phase 3 97240-79-4 5284627
2 Neuroprotective Agents Phase 2, Phase 3
3 Anticonvulsants Phase 2, Phase 3
4 Anti-Obesity Agents Phase 2, Phase 3
5 Protective Agents Phase 2, Phase 3
6
Nitroglycerin Approved, Investigational Not Applicable 55-63-0 4510
7
Salmon Calcitonin Approved, Investigational Not Applicable 47931-85-1 16129616
8
Pancrelipase Approved, Investigational 53608-75-6
9
Calcitonin gene-related peptide Investigational Not Applicable 83652-28-2
10 calcitonin Not Applicable
11 Vasodilator Agents Not Applicable
12 Bone Density Conservation Agents Not Applicable
13 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00131443 Phase 2, Phase 3 Topiramate
2 A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00158002 Phase 2 Topiramate
3 Continuous Treatment Study of Topiramate in Migraine Participants Completed NCT01799590 Phase 2 Topiramate
4 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Completed NCT00541736 Not Applicable Nitroglycerine
5 Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. Completed NCT00358839 Not Applicable CGRP
6 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 Completed NCT00257985 Not Applicable GTN
7 Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA) Completed NCT00687947 Not Applicable CGRP
8 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
9 Pilot Study of Acute Stroke Using the Brainpulse™ Recruiting NCT03235271

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

Anatomical Context for Hemiplegic Migraine

MalaCards organs/tissues related to Hemiplegic Migraine:

41
Brain, Bone, Testes, Trigeminal Ganglion, Thalamus, Tongue, Smooth Muscle

Publications for Hemiplegic Migraine

Articles related to Hemiplegic Migraine:

(show top 50) (show all 426)
# Title Authors Year
1
The Effect of OnabotulinumtoxinA on Aura Frequency and Severity in Patients With Hemiplegic Migraine: Case Series of 11 Patients. ( 29762872 )
2018
2
A Novel ATP1A2 Gene Variant Associated With Pure Sporadic Hemiplegic Migraine Improved After Patent Foramen Ovale Closure: A Case Report. ( 29867740 )
2018
3
Ocular Dipping in a Patient With Hemiplegic Migraine. ( 29384561 )
2018
4
The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families. ( 29486580 )
2018
5
Pediatric sporadic hemiplegic migraine (ATP1A2 gene): a case report and brief literature review. ( 29904856 )
2018
6
Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation. ( 29343472 )
2018
7
Hemiplegic migraine and stroke in Mary Shelley. ( 29553379 )
2018
8
Smooth muscle Ca<sup>2+</sup> sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation. ( 29513112 )
2018
9
Reversible cortical thickening in hemiplegic migraine. ( 28120619 )
2017
10
Ten years of follow-up in a large family with familial hemiplegic migraine type 1: Clinical course and implications for treatment. ( 28856914 )
2017
11
De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report. ( 28593511 )
2017
12
Familial Hemiplegic Migraine With Asymmetric Encephalopathy Secondary to ATP1A2 Mutation: A Case Series. ( 28445178 )
2017
13
The I+2I^2 isoform combination dominates the astrocytic Na(+) /K(+) -ATPase activity and is rendered nonfunctional by the I+2.G301R familial hemiplegic migraine type 2-associated mutation. ( 28787093 )
2017
14
The genetic relationship between epilepsy and hemiplegic migraine. ( 28479855 )
2017
15
Cerebellar Atrophy and Changes in Cytokines Associated with the CACNA1A R583Q Mutation in a Russian Familial Hemiplegic Migraine Type 1 Family. ( 28900389 )
2017
16
Two novel families with hemiplegic migraine caused by recurrent SCN1A mutation p.F1499L. ( 29145747 )
2017
17
Hyperpolarization-activated current Ih in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1. ( 28363781 )
2017
18
Acute Intravenous Calcium Antagonist for Suspected Hemiplegic Migraine - A Case Story. ( 28559833 )
2017
19
Mild Traumatic Brain Injury in a High School Football Player with Familial Hemiplegic Migraine: A Case Report. ( 28918117 )
2017
20
Brain atrophy following hemiplegic migraine attacks. ( 28750589 )
2017
21
First Episode of Hemiplegic Migraine. ( 28601240 )
2017
22
Enhanced susceptibility to cortical spreading depression in two types of Na<sup>+</sup>,K<sup>+</sup>-ATPase I+2 subunit-deficient mice as a model of familial hemiplegic migraine 2. ( 29041816 )
2017
23
Epilepsy in hemiplegic migraine: Genetic mutations and clinical implications. ( 28058944 )
2017
24
Stroke-like attack: first episode of sporadic hemiplegic migraine. ( 28527090 )
2017
25
Identification of the first in Poland CACNA1A gene mutation in familial hemiplegic migraine. Case report. ( 28169007 )
2017
26
Sulcal hyperintensity mimicking subarachnoid hemorrhage in the context of hemiplegic migraine. ( 29236896 )
2017
27
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation. ( 26763045 )
2016
28
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. ( 26911348 )
2016
29
Postoperative Hemiplegic Migraine After a Laparoscopic Cholecystectomy: A Case Report. ( 28045726 )
2016
30
Intermittent Theta Slowings in Contralateral Side of Weakness after Sleep Deprivation on Spot EEG in Sporadic Hemiplegic Migraine. ( 28101483 )
2016
31
A novel SCN1A mutation identified in a Chinese family with familial hemiplegic migraine: A case report. ( 27919014 )
2016
32
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. ( 27346147 )
2016
33
Hemiplegic migraine and late-onset photosensitive epileptic seizures. ( 27406575 )
2016
34
Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1. ( 27314908 )
2016
35
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation. ( 27226003 )
2016
36
A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine. ( 27062528 )
2016
37
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. ( 27354390 )
2016
38
Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack. ( 27155821 )
2016
39
Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report. ( 27790126 )
2016
40
Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation. ( 27818813 )
2016
41
Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide. ( 27538634 )
2016
42
Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine. ( 27175010 )
2016
43
Prevalence of lifetime depression in a large hemiplegic migraine cohort. ( 27807184 )
2016
44
CAPOS syndrome and hemiplegic migraine in a novel pedigree with the specific ATP1A3 mutation. ( 26453127 )
2015
45
Biphasic neurovascular changes in prolonged migraine aura in familial hemiplegic migraine type 2. ( 25411546 )
2015
46
P068. A suggestive case of hemiplegic migraine: a diagnostic challenge. ( 28132306 )
2015
47
Novel frameshift mutation in the CACNA1A gene causing a mixed phenotype of episodic ataxia and familiar hemiplegic migraine. ( 25468264 )
2015
48
Cortical spreading depression and familial hemiplegic migraine 2015. ( 28132368 )
2015
49
Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report. ( 26087244 )
2015
50
Sporadic hemiplegic migraine and giant tumefactive perivascular space: Is there an association? ( 26696413 )
2015

Variations for Hemiplegic Migraine

Expression for Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for Hemiplegic Migraine

Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNB1 GNG2
2
Show member pathways
12.98 CACNA1A GNAI2 GNB1 GNG2 OPRM1 SCN1A
3
Show member pathways
12.97 CACNA1A GNAI2 GNB1 GNG2 SCN1A SCN5A
4
Show member pathways
12.93 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2 SCN5A
5 12.78 GNAI2 GNB1 GNG2 NOTCH3 SLC2A1
6
Show member pathways
12.77 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
7
Show member pathways
12.68 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
8
Show member pathways
12.55 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
9 12.54 CALCA NOTCH3 OPRM1 SCN1A SCN5A
10
Show member pathways
12.51 CACNA1A GNAI2 GNB1 GNG2 OPRM1
11
Show member pathways
12.47 GNAI2 GNB1 GNG2 OPRM1
12
Show member pathways
12.47 ATP1A2 ATP1A3 ATP1B1 ATP1B2
13 12.31 CACNA1A GNAI2 GNB1 GNG2
14
Show member pathways
12.3 CACNA1A GNAI2 GNB1 GNG2 SLC2A1
15
Show member pathways
12.21 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
16
Show member pathways
12.16 GNAI2 GNB1 GNG2 SLC2A1
17 12.07 CALCA GNAI2 GNB1 GNG2
18
Show member pathways
12.07 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
19 12.03 GNAI2 GNB1 GNG2 NOTCH3
20
Show member pathways
11.99 ATP1B1 ATP1B2 CACNA1A CALCA GNAI2 GNB1
21
Show member pathways
11.97 ATP1A2 ATP1A3 ATP1B1 ATP1B2
22 11.91 CACNA1A GNAI2 GNB1 GNG2
23 11.83 ATP1A2 ATP1A3 ATP1B1 ATP1B2
24
Show member pathways
11.81 GNAI2 GNB1 GNG2
25 11.69 ATP1A2 ATP1A3 ATP1B1 ATP1B2
26 11.66 GNAI2 GNB1 GNG2
27 11.64 GNAI2 GNB1 GNG2
28 11.45 GNAI2 GNB1 GNG2
29 11.44 ATP1A2 ATP1A3 ATP1B1 ATP1B2
30 11.4 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SLC2A1
31 11.38 ATP1A2 ATP1A3 ATP1B1 ATP1B2
32 11.31 ATP1A2 ATP1A3 ATP1B1 ATP1B2
33 11.29 GNAI2 GNB1 GNG2
34 11.19 ATP1A2 ATP1A3 ATP1B1 ATP1B2
35 11.16 ATP1A2 ATP1A3 ATP1B1 ATP1B2 NOTCH3 SLC2A1
36 10.93 GNB1 GNG2
37 10.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
38 10.48 GNB1 GNG2

GO Terms for Hemiplegic Migraine

Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.78 ATP1A3 CALCA OPRM1 SCN1A
2 Z disc GO:0030018 9.67 SCN1A SCN5A SLC2A1
3 sarcolemma GO:0042383 9.65 ATP1A2 ATP1B1 OPRM1 SCN5A SLC2A1
4 caveola GO:0005901 9.62 ATP1A2 ATP1B1 SCN5A SLC2A1
5 T-tubule GO:0030315 9.61 ATP1A2 SCN1A SCN5A
6 heterotrimeric G-protein complex GO:0005834 9.58 GNAI2 GNB1 GNG2
7 extracellular vesicle GO:1903561 9.55 ATP1A2 ATP1A3 ATP1B1 GNAI2 GNB1
8 voltage-gated sodium channel complex GO:0001518 9.46 SCN1A SCN5A
9 intercalated disc GO:0014704 9.35 ATP1A2 ATP1B1 SCN1A SCN5A SLC2A1
10 sodium:potassium-exchanging ATPase complex GO:0005890 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
11 plasma membrane GO:0005886 10.21 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.95 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A SCN1A
2 protein folding GO:0006457 9.9 GNAI2 GNB1 GNG2 PRKCSH
3 potassium ion transport GO:0006813 9.85 ATP1A2 ATP1A3 ATP1B1 ATP1B2
4 regulation of cardiac conduction GO:1903779 9.8 ATP1A2 ATP1A3 ATP1B1 ATP1B2
5 sodium ion transport GO:0006814 9.8 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
6 cardiac muscle contraction GO:0060048 9.74 ATP1A2 ATP1B1 SCN5A
7 potassium ion import GO:0010107 9.73 ATP1A2 ATP1A3 ATP1B1 ATP1B2
8 membrane depolarization during action potential GO:0086010 9.7 CACNA1A SCN1A SCN5A
9 cellular sodium ion homeostasis GO:0006883 9.67 ATP1A2 ATP1A3 ATP1B1 ATP1B2
10 response to pain GO:0048265 9.65 CACNA1A CALCA
11 cellular response to prostaglandin E stimulus GO:0071380 9.65 GNB1 GNG2
12 membrane repolarization GO:0086009 9.65 ATP1A2 ATP1B1 ATP1B2
13 cardiac muscle cell action potential involved in contraction GO:0086002 9.64 SCN1A SCN5A
14 G-protein coupled acetylcholine receptor signaling pathway GO:0007213 9.64 GNAI2 GNB1
15 cellular response to steroid hormone stimulus GO:0071383 9.63 ATP1A2 ATP1A3
16 regulation of cardiac muscle cell contraction GO:0086004 9.63 ATP1A2 SCN5A
17 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.63 GNB1 GNG2 OPRM1
18 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.62 ATP1A2 SCN5A
19 relaxation of cardiac muscle GO:0055119 9.62 ATP1A2 ATP1B1
20 neuromuscular process controlling posture GO:0050884 9.61 PRRT2 SCN1A
21 potassium ion import across plasma membrane GO:1990573 9.61 ATP1A2 ATP1B1
22 cellular response to catecholamine stimulus GO:0071870 9.59 GNB1 GNG2
23 positive regulation of potassium ion transmembrane transporter activity GO:1901018 9.58 ATP1B1 ATP1B2
24 response to glycoside GO:1903416 9.58 ATP1A2 ATP1A3
25 positive regulation of sodium ion export across plasma membrane GO:1903278 9.56 ATP1B1 ATP1B2
26 cellular potassium ion homeostasis GO:0030007 9.56 ATP1A2 ATP1A3 ATP1B1 ATP1B2
27 positive regulation of potassium ion import GO:1903288 9.54 ATP1B1 ATP1B2
28 sodium ion export across plasma membrane GO:0036376 9.46 ATP1A2 ATP1A3 ATP1B1 ATP1B2
29 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP1A2 ATP1A3 ATP1B1 ATP1B2
30 cell communication by electrical coupling involved in cardiac conduction GO:0086064 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
31 ion transport GO:0006811 10.05 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A SCN1A

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.58 CACNA1A SCN1A SCN5A
2 potassium ion binding GO:0030955 9.37 ATP1A2 ATP1B1
3 cation channel activity GO:0005261 9.33 CACNA1A SCN1A SCN5A
4 sodium ion binding GO:0031402 9.32 ATP1A2 ATP1B1
5 G-protein beta-subunit binding GO:0031681 9.26 GNG2 OPRM1
6 steroid hormone binding GO:1990239 8.96 ATP1A2 ATP1A3
7 sodium:potassium-exchanging ATPase activity GO:0005391 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2

Sources for Hemiplegic Migraine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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