Hemoglobin D Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Hemoglobin D Disease

MalaCards integrated aliases for Hemoglobin D Disease:

Name: Hemoglobin D Disease ¹² ⁵⁹ ¹⁵ ⁷³

Hb-D Disease ¹²

Hemoglobin D ⁶

Characteristics:

Orphanet epidemiological data:

⁵⁹

hemoglobin d disease
Age of onset: Childhood;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Blood diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Haemolytic anaemias

Other hereditary haemolytic anaemias

Other haemoglobinopathies

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:5378

ICD10 ³³ D58.2

NCIt ⁵⁰ C35344

SNOMED-CT ⁶⁸ 66729008

Orphanet ⁵⁹ ORPHA90039

UMLS via Orphanet ⁷⁴ C0272080

ICD10 via Orphanet ³⁴ D58.2

UMLS ⁷³ C0272080

Sources

Summaries for Hemoglobin D Disease

MalaCards based summary : Hemoglobin D Disease, also known as hb-d disease, is related to sickle cell - hemoglobin d disease and acute chest syndrome. An important gene associated with Hemoglobin D Disease is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways is Factors involved in megakaryocyte development and platelet production.

Sources

Related Diseases for Hemoglobin D Disease

Diseases in the Hemoglobin H Disease family:

Hemoglobin C Disease	Hemoglobin D Disease
Hemoglobin E Disease	Hemoglobin Se Disease

Diseases related to Hemoglobin D Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)

#	Related Disease	Score	Top Affiliating Genes
1	sickle cell - hemoglobin d disease	12.3
2	acute chest syndrome	9.7
3	hemoglobin lepore-beta-thalassemia syndrome	9.6	HBB HBD
4	malignant secondary hypertension	9.6	HBB HBD
5	hemoglobin e disease	9.6	HBB HBD
6	hemoglobin c disease	9.6	HBB HBD
7	osgood-schlatter's disease	9.5	HBB HBD
8	fetal hemoglobin quantitative trait locus 1	9.5	HBB HBD
9	kluver-bucy syndrome	9.5	HBB HBD
10	malignant essential hypertension	9.5	HBB HBD
11	pleuropneumonia	9.5	HBB HBD
12	hemoglobin h disease	9.4	HBB HBD
13	hemoglobinopathy	9.4	HBB HBD
14	sickle cell disease	9.4	HBB HBD
15	congenital hemolytic anemia	9.3	HBB HBD
16	autosomal genetic disease	9.2	HBB HBD
17	thalassemia	9.1	HBB HBD
18	beta-thalassemia	8.9	HBB HBD

Graphical network of the top 20 diseases related to Hemoglobin D Disease:

Sources

Symptoms & Phenotypes for Hemoglobin D Disease

Sources

Drugs & Therapeutics for Hemoglobin D Disease

Search Clinical Trials , NIH Clinical Center for Hemoglobin D Disease

Sources

Genetic Tests for Hemoglobin D Disease

Sources

Anatomical Context for Hemoglobin D Disease

Sources

Publications for Hemoglobin D Disease

Articles related to Hemoglobin D Disease:

#	Title	Authors	Year
1	Pulmonary thromboembolism in a child with sickle cell hemoglobin d disease in the setting of acute chest syndrome. ( 24159402 )	Villanueva H....Sedrak A.	2013
2	First report of successful stem cell transplantation in a patient with sickle cell hemoglobin D disease. ( 20502357 )	Hamidieh A.A....Ghavamzadeh A.	2010
3	Hematological malignancy in hemoglobin D disease. ( 3162650 )	Dash S....Dash R.J.	1988
4	Sickle cell hemoglobin D disease: first reported case in Iran. ( 754514 )	Aflatouni M.M....Malek M.	1978
5	The diagnosis of homozygous hemoglobin D disease. ( 5047609 )	Ringelhann B.	1972
6	Hemoglobin D disease: report of a case. ( 5556213 )	Jain R.C.	1971
7	SICKLE CELL HEMOGLOBIN D DISEASE IN A NEGRO COLOMBIAN PATIENT. ( 14295513 )	Restrepo A.M....LONDONO O.G.	1965

Sources

Genes for Hemoglobin D Disease

Genes related to Hemoglobin D Disease (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HBB	Hemoglobin Subunit Beta	Protein Coding	365.67	Causative germline mutation ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	HBD	Hemoglobin Subunit Delta	Protein Coding	16.48	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	HBQ1	Hemoglobin Subunit Theta 1	Protein Coding	6.5	DISEASES inferred ¹⁵

Sources

Variations for Hemoglobin D Disease

Sources

Expression for Hemoglobin D Disease

Search GEO for disease gene expression data for Hemoglobin D Disease.

Sources

Pathways for Hemoglobin D Disease

Pathways related to Hemoglobin D Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Factors involved in megakaryocyte development and platelet production ⁶⁶	10.82	HBB HBD

Sources

GO Terms for Hemoglobin D Disease

Cellular components related to Hemoglobin D Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood microparticle	GO:0072562	8.96	HBB HBD
2	hemoglobin complex	GO:0005833	8.8	HBB HBD HBQ1

Biological processes related to Hemoglobin D Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:0007596	8.96	HBB HBD
2	oxygen transport	GO:0015671	8.8	HBB HBD HBQ1

Molecular functions related to Hemoglobin D Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	iron ion binding	GO:0005506	9.43	HBB HBD HBQ1
2	heme binding	GO:0020037	9.33	HBB HBD HBQ1
3	oxygen binding	GO:0019825	9.13	HBB HBD HBQ1
4	oxygen carrier activity	GO:0005344	8.8	HBB HBD HBQ1

Sources

Sources for Hemoglobin D Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia