Hemoglobin E Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HMG003 MIFTS: 43	Hemoglobin E Disease Categories: Blood diseases, Endocrine diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Hemoglobin E Disease

MalaCards integrated aliases for Hemoglobin E Disease:

Name: Hemoglobin E Disease ¹² ⁷⁴ ⁵² ⁵⁸ ²⁹ ⁶ ¹⁵ ⁷¹

Hemoglobin E ²⁹ ⁶

Hb-E Disease ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁸

hemoglobin e disease
Inheritance: Autosomal recessive; Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Blood diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³² ³³

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Haemolytic anaemias

Other hereditary haemolytic anaemias

Other haemoglobinopathies

Orphanet: ⁵⁸

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:5379

NCIt ⁴⁹ C35287

SNOMED-CT ⁶⁷ 25065001

ICD10 ³² D58.2

ICD10 via Orphanet ³³ D58.2

UMLS via Orphanet ⁷² C0238159

Orphanet ⁵⁸ ORPHA2133

UMLS ⁷¹ C0238159

Sources

Summaries for Hemoglobin E Disease

NIH Rare Diseases : ⁵² Hemoglobin E (HbE) disease is a mild, inherited blood disorder characterized by an abnormal form of hemoglobin , called hemoglobin E. People with this condition may have very mild anemia , but the condition typically does not cause any symptoms. It is inherited in an autosomal recessive manner and is caused by a mutation in the HBB gene . The mutation that causes hemoglobin E disease primarily occurs in Southeast Asian populations, and rarely in Chinese populations. Most people with HbE disease do not need any treatment.

MalaCards based summary : Hemoglobin E Disease, also known as hemoglobin e, is related to glucosephosphate dehydrogenase deficiency and splenic sequestration. An important gene associated with Hemoglobin E Disease is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord.

Wikipedia : ⁷⁴ Hemoglobin E (HbE) is an abnormal hemoglobin with a single point mutation in the ? chain. At position 26... more...

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Related Diseases for Hemoglobin E Disease

Diseases in the Hemoglobin H Disease family:

Hemoglobin C Disease	Hemoglobin D Disease
Hemoglobin E Disease	Hemoglobin Se Disease

Diseases related to Hemoglobin E Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)

#	Related Disease	Score	Top Affiliating Genes
1	glucosephosphate dehydrogenase deficiency	30.2	HBE1 HBB
2	splenic sequestration	30.1	HBB F2
3	intracranial thrombosis	30.0	F5 F2
4	methemoglobinemia	30.0	LOC107133510 LOC106099062 HBB
5	priapism	29.9	HBB F5
6	placental abruption	29.8	F5 F2
7	mitral valve stenosis	29.8	SERPINA3 F2
8	beta-thalassemia	29.7	HBE1 HBD HBB F2
9	von willebrand's disease	29.6	F5 F2
10	sickle cell disease	29.6	HBD HBB
11	hereditary elliptocytosis	29.3	HBE1 HBB
12	cerebrovascular disease	29.2	SERPINA3 F5 F2
13	fetal hemoglobin quantitative trait locus 1	28.8	LOC107133510 LOC106099062 HBD HBB
14	thalassemia	28.8	LOC106099062 HBQ1 HBE1 HBD HBB F2
15	hemoglobin h disease	28.5	HBQ1 HBE1 HBD HBB
16	hemoglobinopathy	28.0	LOC107133510 LOC106099062 HBQ1 HBE1 HBD HBB
17	alpha-thalassemia	27.7	LOC107133510 LOC106099062 HBQ1 HBE1 HBD HBB
18	hemoglobin se disease	11.7
19	methemoglobinemia, beta-globin type	10.3	LOC107133510 HBB
20	paracetamol poisoning	10.2	F5 F2
21	spinal cord infarction	10.2	F5 F2
22	sudden sensorineural hearing loss	10.2	F5 F2
23	arteritic anterior ischemic optic neuropathy	10.2	F5 F2
24	cryptogenic cirrhosis	10.2	F5 F2
25	splenomegaly	10.2
26	prothrombin deficiency, congenital	10.2	F5 F2
27	cerebral sinovenous thrombosis	10.2	F5 F2
28	sagittal sinus thrombosis	10.2	F5 F2
29	mediastinitis	10.2	F5 F2
30	thrombasthenia	10.2	F5 F2
31	post-thrombotic syndrome	10.2	F5 F2
32	sneddon syndrome	10.2	F5 F2
33	factor x deficiency	10.2	F5 F2
34	peripheral vertigo	10.2	F5 F2
35	porencephaly	10.2	F5 F2
36	factor v deficiency	10.2	F5 F2
37	thrombophilia due to activated protein c resistance	10.2	F5 F2
38	ischemic colitis	10.1	F5 F2
39	dysfibrinogenemia, congenital	10.1	F5 F2
40	factor xiii deficiency	10.1	F5 F2
41	purpura fulminans	10.1	F5 F2
42	antithrombin iii deficiency	10.1	F5 F2
43	factor viii deficiency	10.1	F5 F2
44	thrombophlebitis	10.1	F5 F2
45	retinal vascular occlusion	10.1	F5 F2
46	gastroschisis	10.1	F5 F2
47	central retinal vein occlusion	10.1	F5 F2
48	retinal vein occlusion	10.1	F5 F2
49	factor xi deficiency	10.1	F5 F2
50	inherited blood coagulation disease	10.1	F5 F2

Graphical network of the top 20 diseases related to Hemoglobin E Disease:

Sources

Symptoms & Phenotypes for Hemoglobin E Disease

Sources

Drugs & Therapeutics for Hemoglobin E Disease

Drugs for Hemoglobin E Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Immunologic Factors

Phase 2

Immunoglobulins

Phase 2

Immunoglobulin Fc Fragments

Phase 2

Antibodies

Phase 2

Acetylcysteine

Approved, Investigational

616-91-1

12035

Synonyms:

(2R)-2-acetylamino-3-Sulfanylpropanoate

(2R)-2-acetylamino-3-sulfanylpropanoic acid

(2R)-2-acetylamino-3-Sulfanylpropanoic acid

(2R)-2-acetylamino-3-Sulphanylpropanoate

(2R)-2-acetylamino-3-Sulphanylpropanoic acid

(R)-2-acetylamino-3-Mercaptopropanoate

(R)-2-acetylamino-3-mercaptopropanoic acid

(R)-2-acetylamino-3-Mercaptopropanoic acid

(R)-Mercaptate

(R)-Mercaptic acid

(R)-mercapturic acid

(R)-Mercapturic acid

2-acetylamino-3-mercapto-Propionate

2-acetylamino-3-mercapto-Propionic acid

Ac pharma brand OF acetylcysteine

ACC

Acebraus

Acemuc

Acetabs

Acetadote

Acetilcisteina

Acetylcystein al

Acetylcystein atid

Acetylcystein heumann

Acetylcystein trom

Acetylcystein, mentopin

Acetylcysteine

Acetylcysteine ac-pharma brand

Acetylcysteine alcon brand

Acetylcysteine aluid brand

Acetylcysteine atid brand

Acetylcysteine azupharma brand

Acetylcysteine betapharm brand

Acetylcysteine bioiberica brand

Acetylcysteine bouchara brand

Acetylcysteine centrafarm brand

Acetylcysteine disphar brand

Acetylcysteine farmasan brand

Acetylcysteine fresenius brand

Acetylcysteine génévrier brand

Acétylcystéine GNR

Acetylcysteine GNR-pharma brand

Acetylcysteine guerbet brand

Acetylcysteine hermes brand

Acetylcysteine heumann brand

Acetylcysteine hydrochloride

Acetylcysteine inpharzam brand

Acetylcysteine intra brand

Acetylcysteine klinge brand

Acetylcysteine krewel brand

Acetylcysteine lichtenstein brand

Acetylcysteine lindopharm brand

Acetylcysteine merck brand

Acetylcysteine oberlin brand

Acetylcysteine pfleger brand

Acetylcysteine pharbita brand

Acetylcysteine roberts brand

Acetylcysteine sodium

Acetylcysteine temmler brand

Acetylcysteine teva brand

Acetylcysteine thiemann brand

Acetylcysteine trommsdorff brand

Acetylcysteine upsa brand

Acetylcysteine whitehall brand

Acetylcysteine zambon brand

Acetylcysteine zinc

Acetylcysteine zyma brand

Acetylcysteine, (D)-isomer

Acetylcysteine, (DL)-isomer

Acetylcysteine, monoammonium salt

Acetylcysteine, monosodium salt

Acetylcysteinum

Acetylin

Acetyst

Acid, mercapturic

Ac-pharma brand OF acetylcysteine

Airbron

Alcon brand OF acetylcysteine

Allen and hanburys brand OF acetylcysteine

Aluid brand OF acetylcysteine

Alveolex

Atid brand OF acetylcysteine

Azubronchin

Azupharma brand OF acetylcysteine

Betapharm brand OF acetylcysteine

Bioiberica brand OF acetylcysteine

Bisolvon nac

Boehringer ingelheim brand OF acetylcysteine

Bouchara brand OF acetylcysteine

Bristol myers squibb brand OF acetylcysteine

Bristol myers squibb brand OF acetylcysteine sodium salt

Bristol-myers squibb brand OF acetylcysteine

Bristol-myers squibb brand OF acetylcysteine sodium salt

Bromuc

broncho Fips

broncho-Fips

BronchoFips

Broncholysin

Broncoclar

Centrafarm brand OF acetylcysteine

Codotussyl

Cystamucil

dampo Mucopect

Dey brand OF acetylcysteine sodium salt

Disphar brand OF acetylcysteine

Durabronchal

Eurespiran

Exomuc

Fabrol

Farmasan brand OF acetylcysteine

Fluimicil infantil

Fluimucetin

Fluimucil

Flumucetin

Fluprowit

Frekatuss

Fresenius brand OF acetylcysteine

Genac

Génévrier brand OF acetylcysteine

GNR Pharma brand OF acetylcysteine

GNR-Pharma brand OF acetylcysteine

Guerbet brand OF acetylcysteine

Hermes brand OF acetylcysteine

Heumann brand OF acetylcysteine

Hoestil

Hustengetränk, optipect

Hydrochloride, acetylcysteine

Ilube

Inpharzam brand OF acetylcysteine

Intra brand OF acetylcysteine

Jenacystein

Jenapharm

Klinge brand OF acetylcysteine

Krewel brand OF acetylcysteine

L-a-acetamido-b-Mercaptopropionate

L-a-acetamido-b-Mercaptopropionic acid

L-acetylcysteine

L-Acetylcysteine

L-alpha-acetamido-beta-Mercaptopropionate

L-alpha-acetamido-beta-Mercaptopropionic acid

Lantamed

Larylin nac

Lichtenstein brand OF acetylcysteine

Lindocetyl

Lindopharm brand OF acetylcysteine

Lysox

L-α-acetamido-β-mercaptopropionate

L-α-acetamido-β-mercaptopropionic acid

m Pectil

Mentopin acetylcystein

Mercaptate

Mercaptic acid

Mercapturic acid

Merck brand OF acetylcysteine

Monoammonium salt acetylcysteine

Monosodium salt acetylcysteine

m-Pectil

MPectil

Muciteran

muco Sanigen

Mucolysin

Mucomyst

Mucopect, dampo

Mucosil

Mucosol

Mucosolvin

N Acetyl L cysteine

N Acetylcysteine

NAC

NAC al

NAC zambon

NAC, bisolvon

N-Acetyl-3-mercaptoalanine

N-acetylcysteine

N-Acetylcysteine

N-Acety-L-cysteine

N-acetyl-L-(+)-cysteine

N-Acetyl-L-(+)-cysteine

N-acetyl-L-cysteine

Oberlin brand OF acetylcysteine

Optipect hustengetränk

Parvolex

Pfleger brand OF acetylcysteine

Pharbita brand OF acetylcysteine

Produpharm lappe brand OF acetylcysteine

Roberts brand OF acetylcysteine

Roche nicholas brand OF acetylcysteine

Sanigen, muco

Siccoral

Siran

Sodium 2-acetamido-3-mercaptopropionate

Sodium, acetylcysteine

Solmucol

Temmler brand OF acetylcysteine

Teva brand OF acetylcysteine

Thiemann brand OF acetylcysteine

Trommsdorff brand OF acetylcysteine

UPSA brand OF acetylcysteine

Whitehall brand OF acetylcysteine

Zambon brand OF acetylcysteine

Zambon, nac

Zinc, acetylcysteine

Zyma brand OF acetylcysteine

Tocopherol

Approved, Investigational

1406-66-2, 54-28-4

14986

Synonyms:

3,4-dihydro-2,7,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol

7,8-Dimethyltocol

7,8-dimethyltocolo-Xylotocopherol

Abortosan

adisseo Brand OF tocopherol

Alcala brand OF tocopherol acetate

Aliud brand OF tocopherol

Antioxidans e-hevert

Aquasol e

Arkopharma brand OF tocopherol acetate

AstraZeneca brand OF tocopherol acetate

Atarost brand OF tocopherol acetate

Ausrichter brand OF tocopherol

Auxina e

Balkanpharma brand OF tocopherol

Bayer brand OF tocopherol acetate

bio e

Biocur brand OF tocopherol acetate

biopto-e

Biosan

Bioweyxin

Blackmores brand OF tocopherol

Bottger brand OF tocopherol acetate

Cambridge laboratories brand OF tocopherol actetate

Dal e

Dal vita brand OF vitamin e succinate

Dal-e

Dal-vita brand OF vitamin e succinate

Davitamon

Dermorelle

Detulin

D-gamma-Tocopherol

DL-alpha-Tocopherol

DL-a-Tocopherol

DL-α-tocopherol

Dragees, vitamin-e

e Ferol

e Mulsin

e Vicotrat

e Vitamin e

Ecoro

e-Ferol

Elex verla

Embial

e-Mulsin

Ephynal

Eplonat

Equivit e

Eu rho brand OF tocopherol

EUNOVA vitamin e

Eusovit

e-Vicotrat

EVI-mirale, vitamin-e

Evion

e-Vitamin-ratiopharm

GNR Pharma brand OF tocopherol actetate

GNR-Pharma brand OF tocopherol actetate

Grace brand OF tocopherol

Grunwalder brand OF tocopherol

g-Tocopherol

Hervert brand OF tocopherol acetate

Heyl brand OF tocopherol acetate

Hydrovit e

ICN brand OF tocopherol acetate

Infirmarius rovit brand OF tocopherol

Infirmarius-rovit brand OF tocopherol

Internation animal health brand OF tocopherol acetate

Jenapharm brand OF tocopherol

Kentucky brand OF tocopherol

Kohler brand OF tocopherol

Lasar

Malton e

medphano Brand OF tocopherol acetate

Merck brand OF tocopherol acetate

Methyltocols

Micorvit e

MIP brand OF tocopherol acetate

Mowivit vitamin e

Mucos brand OF tocopherol acetate

Organon brand OF tocopherol acetate

O-Xylotocopherol

puncto e

Ratiopharm brand OF tocopherol

Richelet brand OF tocopherol acetate

Richtavit e

Riemser brand OF tocopherol

Roche nicholas brand OF tocopherol acetate

Rodisma med brand OF tocopherol

Rodisma-med brand OF tocopherol

Sanavitan S

Sanum kehlbeck brand OF tocopherol actetate

Sanum-kehlbeck brand OF tocopherol actetate

Schwarzhaupt brand OF tocopherol acetate

Sciencex brand OF tocopherol acetate

Scot tussin brand OF tocopherol acetate

Scot-tussin brand OF tocopherol acetate

Snow-e muscle, energy and feritility

Spondyvit

Stadapharm brand OF tocopherol

Steigerwald brand OF tocopherol acetate

Strathmann brand OF tocopherol

tocoferol

tocoferoles

Tocolion

Tocopa

Tocopharm

Tocopherol

tocophérol

Tocopherol ausrichter brand

Tocopherol balkanpharma brand

Tocopherol bayer

Tocopherol grace brand

Tocopherol grunwalder brand

Tocopherol infirmarius-rovit brand

Tocopherol kentucky brand

Tocopherol ratiopharm brand

Tocopherol rodisma-med brand

Tocopherol stadapharm brand

Tocopherol togal brand

Tocopherol twardy brand

Tocopherol verla brand

Tocopherol wiedemann brand

Tocopherol worwag brand

Tocopherols

Tocovital

Togal brand OF tocopherol

Togasan vitamin e

Troyapharm brand OF tocopherol acetate

Twardy brand OF tocopherol

Unique e

uno Vit

uno-Vit

UnoVit

Verla brand OF tocopherol

Veyx brand OF tocopherol

Vibolex

Vit e hydrosol

Vit. e stada

Vita e

Vita plus e

Vita-e

VitaE

Vitagutt vitamin e

Vitamin e al

Vitamin e dragees

Vitamin e evi mirale

Vitamin e gamma

Vitamin e MP

Vitamin e natur

Vitamin e sanum

Vitamin e suspension

Vitamin e, mowivit

Vitamin e, togasan

Vitamin e, vitagutt

Vitamin emp

Vitamin e-MP

Vitamin-e dragees

Vitamine e GNR

Vitamin-e evi-mirale

Vita-plus e

VitaPlus e

Vitazell

Wiedemann brand OF tocopherol

Wiedemann brand OF vitamin e succinate

Woelm brand OF tocopherol acetate

Worwag brand OF tocopherol

γ-tocopherol

Iron

Approved, Experimental

7439-89-6, 15438-31-0

23925 27284

Synonyms:

02583_FLUKA

12310_ALDRICH

12310_RIEDEL

129048-51-7

14067-02-8

161135-39-3

190454-13-8

195161-83-2

199281-22-6

209309_ALDRICH

209309_SIAL

255637_ALDRICH

266213_ALDRICH

266256_ALDRICH

267945_ALDRICH

267953_ALDRICH

26Fe

338141_ALDRICH

356808_ALDRICH

356824_ALDRICH

356832_ALDRICH

39344-71-3

3ZhP

413054_ALDRICH

443783-52-6

44890_ALDRICH

44890_FLUKA

675141-17-0

70884-35-4

73135-38-3

7439-89-6

8011-79-8

8053-60-9

AC1L2N38

Ancor B

Ancor en 80/150

armco Iron

Armco iron

Atomel 28

Atomel 300M200

Atomel 500M

Atomel 95

Atomiron 44MR

Atomiron 5M

Atomiron AFP 25

Atomiron AFP 5

ATW 230

ATW 432

C00023

C3518_SIAL

C3518_SIGMA

Carbonyl iron

CCRIS 1580

CHEBI:18248

CID23925

Copy Powder CS 105-175

D007501

DB01592

Diseases (animal), iron overload

Diseases, iron overload

DSP 1000

DSP 128B

DSP 135

DSP 135C

DSP 138

Ed-In-Sol

EF 1000

EF 250

EFV 200/300

EFV 250

EFV 250/400

EINECS 231-096-4

Eisen

Electrolytic iron

F 60 (metal)

FE (II) ion

Fe(2+)

Fe(II)

Fe1+

Fe2+

Fe-40

fer

Feronate

Ferretts

Ferro-Caps

Ferro-Time

Ferrous ion

ferrous iron

Ferrousal

Ferrovac e

Ferrovac E

Ferrum

Ferrum metallicum

FT 3 (element)

GS 6

Hematite

Hemocyte

HF 2 (element)

hierro

Hierro

HL (iron)

Hoeganaes ATW 230

Hoeganaes EH

HQ (metal)

HS (iron)

HS 4849

HSDB 604

Infed

IRMM524A_FLUKA

IRMM524B_FLUKA

IRON

Iron (Fe)

Iron (Fe1+)

Iron ion (Fe+)

Iron ion(1+)

Iron ion(2+)

Iron monocation

Iron powder

Iron standard for AAS

Iron(1+)

Iron(1+) ion

Iron(2+)

Iron(2+) ion

Iron(II) ion

Iron(III) nitrate solution

Iron, carbonyl

Iron, electrolytic

Iron, elemental

Iron, ion (Fe1+)

Iron, ion (Fe1+) (8CI,9CI)

Iron, ion (Fe2+)

Iron, reduced

Limonite

LOHA

LS-3196

Magnetite

Malleable iron

Metopirone

Metyrapone

MolPort-003-925-001

NC 100

PZh1M1

PZh-1M3

PZh-2

PZh2M

PZH2m

PZh2M1

PZh2M2

PZh3

PZh3M

PZh4M

PZhO

PZHO

Reduced iron

Remko

Siderol

Suy-b 2

SUY-B 2

Taconite

UNII-E1UOL152H7

Venofer

Vitedyn-Slo

Wrought iron

Yieronia

Deferiprone

Approved

30652-11-0

2972

Artesunate

Approved, Investigational

88495-63-0

6917864 5464098

Synonyms:

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate

112346-66-4

182824-33-5

252637-87-9

4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano(4,3-j)-1,2-benzodioxepin-10-yl hydrogen butanedioate

4-oxo-4-{[(3r,5as,6r,8as,9r,10r,12r,12ar)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid

4-oxo-4-{[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid

83507-69-1

88495-63-0

91487-94-4

AC1L23PW

AC1L2XWW

AC1L4FU0

AC1Q5VRV

AKOS004119951

Ambap88495-63-0

Arinate

Arsumax

Arsumax (TN)

Artesunate

Artesunate (superseded RN)

Artesunate (USAN)

artesunato

Artesunato

Artesunato [INN-Spanish]

artesunatum

Artesunatum

Artesunatum [INN-Latin]

artesunic acid

Artesunic acid

Artsuna

BB_NC-1045

Butanedioate, 1-[(3R,5as,6R,8as,9R,10S,12R,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-J]-1,2-benzodioxepin-10-yl] ester

Butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester

butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester

Butanedioic acid, 1-[(3R,5as,6R,8as,9R,10S,12R,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-J]-1,2-benzodioxepin-10-yl] ester

Butanedioic acid, mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester

C19H28O8

CHEMBL218601

CHEMBL258608

CID105031

CID11520210

CID11988384

CID156252

CID5464098

CID65664

CID6917864

CID9821433

CPD000466336

D02482

Dihydroartemisinine-12-alpha-succinate

Dihydroqinghaosusuccinate

dihydroqinghasu hemsuccinate

Dihydroqinghasu hemsuccinate

Dihydroqinghasu hemsuccinic acid

FT-0082543

HMS2051I14

HMS2090L16

HSDB 7458

I06-0204

LS-177760

LS-187735

Malacef

Malartin

MLS000759445

MLS001424053

MolPort-001-732-325

MolPort-006-392-384

NCI60_039350

NSC712571

Nuartez

Plasmotrim

Plasmotrin

Qinghaozhi

Quinghaosu reduced succinate ester

S2265_Selleck

SAM001246628

SM 804

SMR000466336

Sodium artesunate

STK801911

Succinyl dihydroartemisinin

UNII-60W3249T9M

WR 256283

WR-256283

Mefloquine

Approved, Investigational

53230-10-7

4046

Synonyms:

(-)-(11S,2'R)-erythro-Mefloquine

(-)-Mefloquine

(-)-Threo-Mefloquine

(+)-(11R,2'S)-erythro-Mefloquine

(+)-Mefloquine

(+)-Threo-Mefloquine

(DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

(R)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol

(R)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol

[(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol

[2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol

49752-90-1

51688-68-7

51742-87-1

51744-84-4

51744-85-5

53230-10-7

68682-27-9

a-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

AB00052310

AC1L1HAJ

AC1L249S

AC1L9UO6

AC1MHD7J

AC1MHD7O

AC1Q4K1I

alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

alpha-2-Piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol

AR-1G4597

BIDD:GT0596

BIDD:PXR0166

BPBio1_000190

BRD-A89585551-003-03-4

BSPBio_000172

C07633

C17H16F6N2O

CAS-51773-92-3

CHEBI:151162

CHEBI:403542

CHEMBL411329

CHEMBL411685

CHEMBL411686

CHEMBL416956

CID3000506

CID3000516

CID4046

CID40692

CID456309

D04895

DB00358

DivK1c_000790

EINECS 256-468-3

Erthro-.alpha.-[2-piperidyl]-2,8-bis[trifluoromethyl]-4-quinolinemethanol

HMS1922C09

HMS502H12

Hoffmann la roche brand OF mefloquine hydrochloride

Hoffmann-la roche brand OF mefloquine hydrochloride

HSDB 6853

IDI1_000790

KBio1_000790

KBio2_001792

KBio2_004360

KBio2_006928

KBio3_002046

KBioGR_001392

KBioSS_001792

Lariam

Lariam (Hydrochloride)

LS-142023

LS-187797

Mefloquin

Mefloquina

Mefloquina [INN-Spanish]

mefloquine

Mefloquine

Méfloquine

Mefloquine (USAN/INN)

Mefloquine [USAN:INN:BAN]

Mefloquine aziridine

Mefloquine HCL

Mefloquine hydrochloride

Mefloquinone

Mefloquinum

Mefloquinum [INN-Latin]

Mephloquine

MolPort-003-981-155

NCGC00016864-01

NCGC00094994-01

NCGC00094994-02

NCGC00094994-03

NCGC00094994-04

NCGC00161831-01

NCGC00161831-02

nchembio.215-comp3

nchembio.87-comp20

NINDS_000790

NSC157387

Prestwick0_000126

Prestwick1_000126

Prestwick2_000126

Prestwick3_000126

Racemic mefloquine

RO 13-7224

RO 13-7225

Ro 215998

Ro 21-5998

Ro 21-5998 (Hydrochloride)

Ro-21-5998-001

Roche brand OF mefloquine hydrochloride

RTI1169-1-1

RTI1172-1-1

RTI1173-1-1

RTI1174-1-1

RTI1188-1-1

RTI1189-1-1

SPB-80406

SPBio_001591

SPBio_002111

Spectrum_001312

SPECTRUM1503070

Spectrum2_001516

Spectrum3_000953

Spectrum4_001066

Spectrum5_001122

UNII-TML814419R

WR 142490

WR-142,490

WR-142490

WR-177,602

α-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

Vitamin E

Approved, Nutraceutical, Vet_approved

59-02-9

14985

Synonyms:

(+)-alpha-Tocopherol

(+)-a-Tocopherol

(+)-α-tocopherol

(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL

(2R)-3,4-dihydro-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol

(2R,4'r,8'r)-alpha-Tocopherol

(2R,4'r,8'r)-a-Tocopherol

(2R,4'r,8'r)-α-tocopherol

(2R,4'R,8'R)-α-tocopherol

(R,R,R)-alpha-Tocopherol

(R,R,R)-a-Tocopherol

(R,R,R)-α-tocopherol

5,7,8-trimethyltocol

5,7,8-Trimethyltocol

a-D-Tocopherol

alpha-delta-Tocopherol

alpha-tocopherol

alpha-Tocopherol

Amino-Opti-E

Aquasol E

a-Tocopherol

D-alpha-Tocopherol

Daltose

D-a-Tocopherol

delta-alpha-Tocopherol

Denamone

d-α-tocopherol

D-α-tocopherol

E-200 I.U. Softgels

E-Complex-600

E-Ferol

Eprolin

E-Vitamin succinate

Gordo-Vite E

Phytogermin

Phytogermine

RRR-alpha-Tocopherol

RRR-alpha-Tocopheryl

Tocopherol

Vitamin e

Vitamin ea

Vitamin Plus E Softgells

Vitec

α-tocopherol

Tocotrienol

Investigational

6829-55-6

Piperaquine

Experimental, Investigational

4085-31-8

5079497

Synonyms:

1,3-bis(1-(7-chloro-4'-quinolyl)-4'-piperazinyl)propane

1,3-bis(4-(7'-chloro-4'-quinoline)-1-piperazine)

1,3-bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane

4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline)

4085-31-8

5-23-03-00072 (Beilstein Handbook Reference)

7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline

83764-65-2

AC1L3UA1

AC1Q3T7B

AR-1F7471

BRN 0905079

C29H32Cl2N6

CHEMBL303933

CID122262

FT-0082661

I06-1673

LS-142194

piperaquine

Piperaquinoline

Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro- (9CI)

Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-)

ST51053186

Vitamins

Micronutrients

Trace Elements

Respiratory System Agents

Tocopherols

Anti-Infective Agents

Antioxidants

Nutrients

Free Radical Scavengers

Tocotrienols

N-monoacetylcystine

Antiviral Agents

Chelating Agents

Iron Chelating Agents

Protective Agents

Antidotes

Expectorants

Artemisinins

Antiparasitic Agents

Antiprotozoal Agents

Antimalarials

Artemisinine

Anthelmintics

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Multi-National, Blinded, Placebo-Controlled, Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HQK-1001 in Subjects With Beta Thalassemia Intermedia, Including Hemoglobin E Beta Thalassemia	Completed	NCT00790127	Phase 1, Phase 2	HQK-1001;Placebo
2	An Open Label Academic Phase 2 Study of SDMB in Subjects in Thailand With Beta Thalassemia Intermedia	Completed	NCT01609595	Phase 2	sodium 2,2 dimethylbutyrate
3	A Phase 2A Open-label Multicenter Study to Evaluate the Safety and Pharmacokinetics of Luspatercept in Pediatric Subjects Who Require Regular Red Blood Cell Transfusions Due to B-Thalassemia	Not yet recruiting	NCT04143724	Phase 2	ACE-536;ACE-536
4	Compassionate Use of Catheter Thrombectomy (Aspirex 11F) in Patients With Massive Pulmonary Embolism	Terminated	NCT00314002	Phase 1, Phase 2
5	Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E Patients	Completed	NCT01597765		curcuminoids, N-acetylcysteine, deferiprone and vitamin E;Curcuminoids and alpha-tocopherol
6	Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern Cambodia	Completed	NCT01240603
7	Studies of P. Vivax and P. Falciparum Malaria in Cambodia	Completed	NCT00663546
8	Multidisciplinary Studies of Severe Malaria and Antimalarial Drug Resistance in Cambodia	Completed	NCT00341003

Search NIH Clinical Center for Hemoglobin E Disease

Sources

Genetic Tests for Hemoglobin E Disease

Genetic tests related to Hemoglobin E Disease:

#	Genetic test	Affiliating Genes
1	Hemoglobin E ²⁹
2	Hemoglobin E Disease ²⁹

Sources

Anatomical Context for Hemoglobin E Disease

MalaCards organs/tissues related to Hemoglobin E Disease:

⁴⁰

Bone, Testes, Spinal Cord, Heart, Endothelial, Bone Marrow, Colon

Sources

Publications for Hemoglobin E Disease

Articles related to Hemoglobin E Disease:

(show top 50) (show all 567)

#	Title	Authors	PMID	Year
1	Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. ⁶¹ ⁶	Ohashi J...Tokunaga K	15114532	2004
2	The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): hematologic and evolutionary implications. ⁶¹ ⁶	Premawardhena A...Weatherall DJ	12850492	2003
3	Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria. ⁶¹ ⁶	Chotivanich K...White N	12149194	2002
4	Interaction of hemoglobin E and pyrimidine 5' nucleotidase deficiency. ⁶¹ ⁶	Rees DC...Weatherall DJ	8839873	1996
5	Sickle cell-hemoglobin E disease: clinical findings and implications. ⁶¹ ⁶	Rey KS...Miller ST	1960615	1991
6	Homozygous hemoglobin E mimics beta-thalassemia minor without anemia or hemolysis: hematologic, functional, and biosynthetic studies of first North American cases. ⁶¹ ⁶	Fairbanks VF...Fiester RF	7395858	1980
7	Interaction of malaria with a common form of severe thalassemia in an Asian population. ⁶	O'Donnell A...Weatherall DJ	19841268	2009
8	Global epidemiology of haemoglobin disorders and derived service indicators. ⁶	Modell B...Darlison M	18568278	2008
9	Hyperbilirubinemia in homozygous HbE disease is associated with the UGT1A1 gene polymorphism. ⁶	Edison ES...Chandy M	16114182	2005
10	Genotypes and phenotypes--another lesson from the hemoglobinopathies. ⁶	Benz EJ	15470211	2004
11	The 'hot-spot' of Hb E [beta26(B8)Glu-->Lys] in Southeast Asia: beta-globin anomalies in the Lao Theung population of southern Laos. ⁶	Flatz G...Horst J	15481886	2004
12	Homozygosity for Hb E-Saskatoon [beta22(B4)Glu-->Lys] in a Turkish patient. ⁶	Birben E...Altay C	11791874	2001
13	Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia. ⁶	Premawardhena A...Weatherall DJ	11425418	2001
14	Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? ⁶	Beutler E...Demina A	9653159	1998
15	The first case of Hb E-Saskatoon [alpha 2 beta(2)22(B4)Glu-->Lys] in a Japanese male in Asia. ⁶	Igarashi Y...Fushitani K	8718699	1995
16	Compound heterozygosity for Hb E-Saskatoon or alpha 2 beta 2(22)(B4)Glu----Lys and beta-thalassemia type IVS-I-6 (T----C) ⁶	Gurgey A...Aksoy M	2283299	1990
17	Direct detection of haemoglobin E with MnlI. ⁶	Thein SL...Weatherall DJ	3031297	1987
18	Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. ⁶	Orkin SH...Giardina PJ	6280057	1982
19	Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster. ⁶	Antonarakis SE...Kazazian HH	6275383	1982
20	A genetically determined disorder with features both of thalassaemia and congenital dyserythropoietic anaemia. ⁶	Weatherall DJ...Temperley IJ	4351905	1973
21	Hemoglobin variant common to Chinese and North American Indians: alpha-2-beta-22 Glu-Ala. ⁶	Blackwell RW...Huang JT	5658717	1968
22	Hemoglobin G Saskatoon: beta-22Glu--Ala. ⁶	Vella F...Lehmann H	6021187	1967
23	Abnormal human haemoglobins. VI. The chemical difference between haemoglobins A and E. ⁶	HUNT JA...INGRAM VM	13716853	1961
24	Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population. ⁶¹	Noor FA...Mannoor K	31941534	2020
25	[Hematological and genotypic features of 100 patients with hemoglobin E disorders from Yunnan Province]. ⁶¹	Yang J...Wang K	31922592	2020
26	A novel SNP rs11759328 on Rho GTPase-activating protein 18 gene is associated with the expression of Hb F in hemoglobin E-related disorders. ⁶¹	Jomoui W...Fucharoen S	31776727	2020
27	Comparison Between Three Molecular Diagnostics for the Identification of Heterozygous Hemoglobin E. ⁶¹	Arif AA...Handayani NSN	31930879	2020
28	Pharmacokinetics and pharmacodynamics of single dose of inhaled nebulized sodium nitrite in healthy and hemoglobin E/β-thalassemia subjects. ⁶¹	Sirirat K...Sibmooh N	31513867	2019
29	Interactions of unstable hemoglobin Rush with thalassemia and hemoglobin E result in thalassemia intermedia. ⁶¹	Huang K...Yang Z	31124399	2019
30	Differentially expressed plasma proteins of β-thalassemia/hemoglobin E patients in response to curcuminoids/vitamin E antioxidant cocktails. ⁶¹	Panachan J...Kalpravidh RW	30661467	2019
31	Undiagnosed Hemoglobinopathies: A potential threat to the premarital screening program. ⁶¹	Hamali HA...Saboor M	31777502	2019
32	Determination of Normal HbA1C Levels in Non-Diabetic Patients with Hemoglobin E. ⁶¹	Pongudom S...Chinthammitr Y	31882432	2019
33	Prevalence of left ventricular diastolic dysfunction by cardiac magnetic resonance imaging in thalassemia major patients with normal left ventricular systolic function. ⁶¹	Chinprateep B...Krittayaphong R	31694552	2019
34	[Phenotype Analysis of 78 Cases of Abnormal Hemoglobin E Homozygotes]. ⁶¹	Pan YH...Yang ZQ	31607315	2019
35	Molecular prevalence of thalassemia and hemoglobinopathies among the Lao Loum Group in the Lao People's Democratic Republic. ⁶¹	Phanmany S...Leecharoenkiat K	31271507	2019
36	A case of compound heterozygous hemoglobin Köln/hemoglobin E in an Indian family. ⁶¹	Mittal N...Agarwal S	31424305	2019
37	Validation of Microarray for the Simultaneous Detection of Common α- and β-Thalassemia Gene Mutations. ⁶¹	Pornprasert S...Pongpunyayuen P	30806653	2019
38	Differentiation of homozygous hemoglobin E and hemoglobin E-β0 -thalassemia in children. ⁶¹	Arong A...Fucharoen S	30582675	2019
39	The first report of hemoglobin E in combination with the highly unstable alpha-globin variant Hb Adana: The importance of molecular confirmation. ⁶¹	Achour A...Harteveld CL	30663218	2019
40	Blood transfusion therapy for β-thalassemia major and hemoglobin E β-thalassemia: Adequacy, trends, and determinants in Sri Lanka. ⁶¹	Mettananda S...Premawardhena A	30697927	2019
41	A Formula to Identify Potential Cases of β-Thalassemia/HbE Disease Among Patients With Absent HbA, HbE >75% and HbF Between 5 and 15. ⁶¹	Pornprasert S...Kongthai K	30239825	2019
42	Hemoglobin A1c Levels Are Slightly but Significantly Lower in Normoglycemic Subjects With the Hemoglobin E Phenotype. ⁶¹	Pratumvinit B...Loh TP	30430785	2019
43	Comparative Proteome-Wide Analysis of Bone Marrow Microenvironment of β-Thalassemia/Hemoglobin E. ⁶¹	Ponnikorn S...Hongeng S	30813444	2019
44	Vascular and hemostatic alterations associated with pulmonary hypertension in β-thalassemia hemoglobin E patients receiving regular transfusion and iron chelation. ⁶¹	Uaprasert N...Rojnuckarin P	30584959	2019
45	Molecular Analysis of Non-Transfusion Dependent Thalassemia Associated with Hemoglobin E-β-Thalassemia Disease without α-Thalassemia. ⁶¹	Phanrahan P...Fucharoen S	31308914	2019
46	The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen-matched red blood cells for thalassemia transfusions: a 10-year experience at a tertiary care hospital. ⁶¹	Romphruk AV...Puapairoj C	30443908	2019
47	A nationwide survey of hospital-based thalassemia patients and standards of care and a preliminary assessment of the national prevention program in Sri Lanka. ⁶¹	Premawardhana AP...Oliveri NF	31419232	2019
48	Hemoglobin E, malaria and natural selection. ⁶¹	Ha J...Nishi A	31890210	2019
49	Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center. ⁶¹	Satirapod C...Hongeng S	31751397	2019
50	Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border. ⁶¹	Deng Z...Cui L	29964138	2018

Sources

Genes for Hemoglobin E Disease

Genes related to Hemoglobin E Disease (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	HBB	Hemoglobin Subunit Beta	Protein Coding	773.07	Pathogenic ⁶ Causative germline mutation ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	8839873 8718699 5658717 (more) 4351905 7395858 16114182 6021187 11425418 15114532 11791874 12149194 13716853 3031297 1960615 6280057 15470211 6275383 9653159 2283299 15481886 12850492 18568278 19841268
2	F2	Coagulation Factor II, Thrombin	Protein Coding	11.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	HBE1	Hemoglobin Subunit Epsilon 1	Protein Coding	9.27	DISEASES inferred ¹⁵
4	SERPINA3	Serpin Family A Member 3	Protein Coding	7.74	DISEASES inferred ¹⁵ ¹⁵
5	HBD	Hemoglobin Subunit Delta	Protein Coding	7.57	DISEASES inferred ¹⁵
6	LOC106099062	HBB Recombination Region	Biological Region	7.48	GeneCards inferred via : Variants (show sections)
7	LOC107133510	Origin Of Replication At HBB	Biological Region	7.48	GeneCards inferred via : Variants (show sections)
8	HBQ1	Hemoglobin Subunit Theta 1	Protein Coding	7.42	DISEASES inferred ¹⁵
9	F5	Coagulation Factor V	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)

Sources

Variations for Hemoglobin E Disease

ClinVar genetic disease variations for Hemoglobin E Disease:

⁶ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	HBB	NM_000518.5(HBB):c.79G>A (p.Glu27Lys)	SNV	Pathogenic	15161	rs33950507	11:5248173-5248173	11:5226943-5226943
2	HBB	NM_000518.4(HBB):c.67G>A (p.Glu23Lys)	SNV	Uncertain significance	15162	rs33959855	11:5248185-5248185	11:5226955-5226955

Sources

Expression for Hemoglobin E Disease

Search GEO for disease gene expression data for Hemoglobin E Disease.

Sources

Pathways for Hemoglobin E Disease

Pathways related to Hemoglobin E Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	12.18	SERPINA3 HBE1 HBD HBB F5 F2
2	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.66	SERPINA3 HBB F2
3	Factors involved in megakaryocyte development and platelet production ⁶⁵	11.33	HBE1 HBD HBB

Sources

GO Terms for Hemoglobin E Disease

Cellular components related to Hemoglobin E Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood microparticle	GO:0072562	9.55	SERPINA3 HBE1 HBD HBB F2
2	platelet alpha granule lumen	GO:0031093	9.26	SERPINA3 F5
3	hemoglobin complex	GO:0005833	9.26	HBQ1 HBE1 HBD HBB
4	haptoglobin-hemoglobin complex	GO:0031838	8.92	HBQ1 HBE1 HBD HBB

Biological processes related to Hemoglobin E Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular oxidant detoxification	GO:0098869	9.56	HBQ1 HBE1 HBD HBB
2	blood coagulation	GO:0007596	9.55	HBE1 HBD HBB F5 F2
3	hemostasis	GO:0007599	9.37	F5 F2
4	acute-phase response	GO:0006953	9.32	SERPINA3 F2
5	hydrogen peroxide catabolic process	GO:0042744	9.26	HBQ1 HBE1 HBD HBB
6	oxygen transport	GO:0015671	8.92	HBQ1 HBE1 HBD HBB

Molecular functions related to Hemoglobin E Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.71	HBQ1 HBE1 HBD HBB
2	peroxidase activity	GO:0004601	9.62	HBQ1 HBE1 HBD HBB
3	oxygen binding	GO:0019825	9.56	HBQ1 HBE1 HBD HBB
4	hemoglobin alpha binding	GO:0031721	9.54	HBE1 HBD HBB
5	oxygen carrier activity	GO:0005344	9.46	HBQ1 HBE1 HBD HBB
6	organic acid binding	GO:0043177	9.26	HBQ1 HBE1 HBD HBB
7	haptoglobin binding	GO:0031720	8.92	HBQ1 HBE1 HBD HBB

Sources

Sources for Hemoglobin E Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia