MCID: HMG009
MIFTS: 23

Hemoglobin Zurich

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hemoglobin Zurich

MalaCards integrated aliases for Hemoglobin Zurich:

Name: Hemoglobin Zurich 53 6
Hb-Zurich 53

Classifications:



Summaries for Hemoglobin Zurich

NIH Rare Diseases : 53 Hemoglobin (Hb) Zurich is an inheritedblood disorder. People with Hb Zurich have an abnormal form of Hb, a red blood cell (RBC) protein that binds to oxygen in the lungs. This abnormal Hb more readily binds to carbon monoxide (producing carboxyhemoglobin or COHb). Normally the level of COHb is less than 1-2% in adults. People with Hb Zurich tend to have COHb levels above 3%. The health effects of Hb Zurich tend to be mild compared to other inherited blood cell disorders. Symptoms usually develop only when the body is stressed due to an infection or fever or when exposed to certain drugs. Symptoms develop as a result of the premature breakdown of RBC (hemolytic anemia). Click here to visit MedlinePlus.gov and view an illustration of hemoglobin.

MalaCards based summary : Hemoglobin Zurich, also known as hb-zurich, is related to thalassemia and alpha-thalassemia. An important gene associated with Hemoglobin Zurich is HBA2 (Hemoglobin Subunit Alpha 2), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria. Affiliated tissues include lung.

Related Diseases for Hemoglobin Zurich

Graphical network of the top 20 diseases related to Hemoglobin Zurich:



Diseases related to Hemoglobin Zurich

Symptoms & Phenotypes for Hemoglobin Zurich

Drugs & Therapeutics for Hemoglobin Zurich

Search Clinical Trials , NIH Clinical Center for Hemoglobin Zurich

Genetic Tests for Hemoglobin Zurich

Anatomical Context for Hemoglobin Zurich

MalaCards organs/tissues related to Hemoglobin Zurich:

41
Lung

Publications for Hemoglobin Zurich

Articles related to Hemoglobin Zurich:

(show all 22)
# Title Authors Year
1
Severe anemia after trans-catheter arterial chemoembolization-an unusual presentation of hemoglobin Zurich. ( 29740684 )
2018
2
Thalassemia major phenotype caused by HB Zürich-Albisrieden [α2 59(E8) Gly > Arg (HBA2:C.178G > C)] in a Brazilian child. ( 30151892 )
2018
3
Hemoglobin Zurich and cardiopulmonary bypass. ( 11139114 )
2000
4
Molecular diagnosis and characterization of Hb Zürich [beta63(E7)His-->Arg]] carriers in a Kentucky family. ( 9859934 )
1998
5
Hb Zürich [beta 63(E7)His-->Arg] found in a Japanese woman. ( 8936468 )
1996
6
Identification of Hb Zürich [alpha 2 beta 2(63)(E7)His-->Arg] by DNA analysis in a Brazilian family. ( 7852089 )
1994
7
Distal His----Arg mutation in bovine myoglobin results in a ligand binding site similar to the abnormal beta site of hemoglobin Zurich (beta 63 His----Arg). ( 2912443 )
1989
8
Hemichrome formation during hemoglobin Zurich denaturation. ( 2854954 )
1988
9
Studies on the oxidation of hemoglobin Zurich (beta 63 E7 Arg). ( 6096143 )
1984
10
Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro. ( 6859031 )
1983
11
First Japanese family with the unstable hemoglobin Zürich [beta 63(e7) His leads to Arg]. ( 6175783 )
1982
12
Carboxyhemoglobin levels in an unstable hemoglobin disorder (Hb Zürich): effect on phenotypic expression. ( 7384813 )
1980
13
Observations on the rate and mechanism of hemolysis in individuals with Hb Zürich [His E7(63)beta leads to Arg]: II. Thermal denaturation of hemoglobin as a cause of anemia during fever. ( 439565 )
1979
14
Observations on the rate and mechanism of hemolysis in individuals with Hb Zürich [His E7 (63)beta leads to Arg]: I. Concentrations of haptoglobin and hemopexin in the serum. ( 762915 )
1979
15
Binding of carbon monoxide to hemoglobin Zürich. Proposal for a kinetic model. ( 862620 )
1977
16
Properties of hemoglobin A and hemoglobin Zurich (beta63 histidine replaced by arginine): quantitative evaluation of functional abnormalities in hemoglobins. ( 1267786 )
1976
17
Subunit interactions in abnormal hemoglobins (Hb Zürich and Hb Abruzzo). ( 955098 )
1976
18
Electron-spin resonance of nitrosyl haemoglobins: normal alpha and beta chains and mutants Hb M Iwate and Hb Zürich. ( 235432 )
1975
19
A resonance Raman study on Hb M Iwate (alpha87His leads to Tyr beta)2, and Hb Zürich (alpha beta 63 His-Arg). 2. ( 4430367 )
1974
20
Hemoglobin Zurich. I. A new hemoglobin anomaly associated with acute hemolytic episodes with inclusion bodies after sulfonamide therapy. ( 13895148 )
1962
21
Hemoglobin Zurich. II. Physicochemical properties of the abnormal hemoglobin. ( 13863728 )
1962
22
A new abnormal human hemoglobin-Hb: Zurich. ( 13716725 )
1961

Variations for Hemoglobin Zurich

ClinVar genetic disease variations for Hemoglobin Zurich:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HBB NM_000518.4(HBB): c.191A> G (p.His64Arg) single nucleotide variant other rs33985544 GRCh37 Chromosome 11, 5247931: 5247931
2 HBB NM_000518.4(HBB): c.191A> G (p.His64Arg) single nucleotide variant other rs33985544 GRCh38 Chromosome 11, 5226701: 5226701

Expression for Hemoglobin Zurich

Search GEO for disease gene expression data for Hemoglobin Zurich.

Pathways for Hemoglobin Zurich

GO Terms for Hemoglobin Zurich

Cellular components related to Hemoglobin Zurich according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.26 HBA2 HBB
2 endocytic vesicle lumen GO:0071682 9.16 HBA2 HBB
3 hemoglobin complex GO:0005833 8.96 HBA2 HBB
4 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA2 HBB

Biological processes related to Hemoglobin Zurich according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.43 HBA2 HBB
2 cellular oxidant detoxification GO:0098869 9.4 HBA2 HBB
3 protein heterooligomerization GO:0051291 9.37 HBA2 HBB
4 response to hydrogen peroxide GO:0042542 9.32 HBA2 HBB
5 positive regulation of cell death GO:0010942 9.26 HBA2 HBB
6 bicarbonate transport GO:0015701 9.16 HBA2 HBB
7 hydrogen peroxide catabolic process GO:0042744 8.96 HBA2 HBB
8 oxygen transport GO:0015671 8.62 HBA2 HBB

Molecular functions related to Hemoglobin Zurich according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.37 HBA2 HBB
2 oxygen binding GO:0019825 9.32 HBA2 HBB
3 peroxidase activity GO:0004601 9.26 HBA2 HBB
4 oxygen carrier activity GO:0005344 9.16 HBA2 HBB
5 organic acid binding GO:0043177 8.96 HBA2 HBB
6 haptoglobin binding GO:0031720 8.62 HBA2 HBB

Sources for Hemoglobin Zurich

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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