MCID: HMG009
MIFTS: 21

Hemoglobin Zurich

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hemoglobin Zurich

MalaCards integrated aliases for Hemoglobin Zurich:

Name: Hemoglobin Zurich 20 6
Hb-Zurich 20

Classifications:



Summaries for Hemoglobin Zurich

GARD : 20 Hemoglobin (Hb) Zurich is an inherited blood disorder. People with Hb Zurich have an abnormal form of Hb, a red blood cell (RBC) protein that binds to oxygen in the lungs. This abnormal Hb more readily binds to carbon monoxide (producing carboxyhemoglobin or COHb). Normally the level of COHb is less than 1-2% in adults. People with Hb Zurich tend to have COHb levels above 3%. The health effects of Hb Zurich tend to be mild compared to other inherited blood cell disorders. Symptoms usually develop only when the body is stressed due to an infection or fever or when exposed to certain drugs. Symptoms develop as a result of the premature breakdown of RBC ( hemolytic anemia ). Click here to visit MedlinePlus.gov and view an illustration of hemoglobin.

MalaCards based summary : Hemoglobin Zurich, also known as hb-zurich, is related to hemoglobinopathy and beta-thalassemia. An important gene associated with Hemoglobin Zurich is HBA2 (Hemoglobin Subunit Alpha 2), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria.

Related Diseases for Hemoglobin Zurich

Diseases related to Hemoglobin Zurich via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 hemoglobinopathy 29.1 LOC107133510 LOC106099062 HBB HBA2
2 beta-thalassemia 29.0 LOC107133510 LOC106099062 HBB HBA2
3 alpha-thalassemia 28.4 LOC107133510 LOC106804612 LOC106099062 HBB HBA2
4 thalassemia 28.4 LOC107133510 LOC106804612 LOC106099062 HBB HBA2
5 deficiency anemia 28.3 LOC107133510 LOC106804612 LOC106099062 HBB HBA2
6 glutathione peroxidase deficiency 10.0 HBB HBA2
7 hydrops fetalis, nonimmune 10.0
8 lymphatic malformation 7 10.0
9 hypochromic microcytic anemia 9.9 HBB HBA2
10 hemoglobin d disease 9.9 LOC107133510 HBB
11 histiocytosis-lymphadenopathy plus syndrome 9.9 HBB HBA2
12 erythrocytosis, familial, 7 9.8 LOC106804612 HBA2
13 congenital hemolytic anemia 9.8 HBB HBA2
14 hemoglobin e-beta-thalassemia syndrome 9.7 LOC107133510 LOC106099062 HBB
15 polycythemia 9.7 HBB HBA2
16 splenomegaly 9.7 LOC106804612 HBA2
17 sickle cell disease and related diseases 9.7 LOC107133510 LOC106099062 HBB
18 beta-thalassemia intermedia 9.7 LOC107133510 LOC106099062 HBB
19 methemoglobinemia, beta type 9.7 LOC107133510 LOC106099062 HBB
20 beta-thalassemia, dominant inclusion body type 9.7 LOC107133510 LOC106099062 HBB
21 splenic infarction 9.6 LOC107133510 LOC106099062 HBB
22 hemoglobin c disease 9.6 LOC107133510 LOC106099062 HBB
23 beta-thalassemia major 9.6 LOC107133510 LOC106099062 HBB
24 hemoglobin e disease 9.6 LOC107133510 LOC106099062 HBB
25 fetal hemoglobin quantitative trait locus 1 9.6 LOC107133510 LOC106099062 HBB
26 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 9.6 LOC107133510 LOC106099062 HBB
27 erythrocytosis, familial, 6 9.6 LOC107133510 LOC106099062 HBB
28 hemoglobin se disease 9.6 LOC107133510 LOC106099062 HBB
29 hemoglobin h disease 9.5 LOC106804612 HBB HBA2
30 methemoglobinemia 9.4 LOC107133510 LOC106099062 HBB HBA2
31 methemoglobinemia, beta-globin type 9.4 LOC107133510 LOC106099062 HBB HBA2
32 thalassemia minor 9.4 LOC107133510 LOC106099062 HBB HBA2
33 sickle cell disease 9.4 LOC107133510 LOC106099062 HBB HBA2
34 sickle cell anemia 9.4 LOC107133510 LOC106099062 HBB HBA2
35 hemolytic anemia 9.4 LOC107133510 LOC106099062 HBB HBA2
36 malaria 9.3 LOC107133510 LOC106099062 HBB HBA2
37 heinz body anemias 9.0 LOC107133510 LOC106804612 LOC106099062 HBB HBA2

Graphical network of the top 20 diseases related to Hemoglobin Zurich:



Diseases related to Hemoglobin Zurich

Symptoms & Phenotypes for Hemoglobin Zurich

Drugs & Therapeutics for Hemoglobin Zurich

Search Clinical Trials , NIH Clinical Center for Hemoglobin Zurich

Genetic Tests for Hemoglobin Zurich

Anatomical Context for Hemoglobin Zurich

Publications for Hemoglobin Zurich

Articles related to Hemoglobin Zurich:

(show all 28)
# Title Authors PMID Year
1
A new form of thalassemia intermedia: Compound heterozygous beta thalassemia and hemoglobin Zurich. 61
30900795 2019
2
Severe anemia after trans-catheter arterial chemoembolization-an unusual presentation of hemoglobin Zurich. 61
29740684 2018
3
Hydrops Fetalis Associated with Compound Heterozygosity for Hb Zurich-Albisrieden (HBA2: C.178G > C) and the Southeast Asian (- -SEA/) Deletion. 61
27686733 2016
4
[Diagnosis and prenatal diagnosis to a family of hemoglobin variant with α-thalassemia]. 61
25863092 2015
5
The Hb H disease genotypes in Southern China. 61
24261598 2014
6
[Prevalence and molecular analysis of β-thalassemia in children of Han ethnicity in Chongqing city]. 61
24267133 2013
7
Mass spectrometry: a tool for enhanced detection of hemoglobin variants. 61
17932132 2008
8
A new highly unstable alpha chain variant causing alpha(+)-thalassemia: Hb Zurich Albisrieden [alpha59(E8)Gly-->Arg (alpha2)]. 61
15658192 2004
9
Detection of a novel variant human hemoglobin by electrospray ionization mass spectrometry. 61
11944920 2002
10
Hemoglobin Zurich and cardiopulmonary bypass. 61
11139114 2000
11
Distal His----Arg mutation in bovine myoglobin results in a ligand binding site similar to the abnormal beta site of hemoglobin Zurich (beta 63 His----Arg). 61
2912443 1989
12
Hemichrome formation during hemoglobin Zurich denaturation. 61
2854954 1988
13
Oxygen infrared spectra of oxyhemoglobins and oxymyoglobins. Evidence of two major liganded O2 structures. 61
3663620 1987
14
Isocyanide binding kinetics to monomeric hemoproteins. A study on the ligand partition between solvent and heme pocket. 61
3567310 1987
15
Mechanism of electron transfer to coordinated dioxygen of oxyhemoglobins to yield peroxide and methemoglobin. Protein control of electron donation by aquopentacyanoferrate(II). 61
3988729 1985
16
Studies on the oxidation of hemoglobin Zurich (beta 63 E7 Arg). 61
6096143 1984
17
Functional studies on hemoglobin opossum. Conclusions drawn regarding the role of the distal histidine. 61
7118915 1982
18
[Open heart surgery in a case of unstable hemoglobinopathy (Hb Zurich)]. 61
7175258 1982
19
Evidence from infrared and 13C NMR spectra for discrete rapidly interconverting conformers at the carbon monoxide binding sites of hemoglobins A and Zurich. 61
7462226 1981
20
Carboxyhemoglobin levels in an unstable hemoglobin disorder (Hb Zürich): effect on phenotypic expression. 61
7384813 1980
21
Cobalt-substituted hemoglobin Zürich (alpha 2 beta 263His leads Arg). Oxygen equilibria and EPR spectra. 61
232666 1979
22
Properties of hemoglobin A and hemoglobin Zurich (beta63 histidine replaced by arginine): quantitative evaluation of functional abnormalities in hemoglobins. 61
1267786 1976
23
A Swiss family with hemoglobin P Galveston beta117His leads to Arg, including two patients with hb P/beta thalassemia. 61
1164567 1975
24
Electron-spin resonance of nitrosyl haemoglobins: normal alpha and beta chains and mutants Hb M Iwate and Hb Zürich. 61
235432 1975
25
Hemoglobin Zurich. II. Physicochemical properties of the abnormal hemoglobin. 61
13863728 1962
26
Hemoglobin Zurich. I. A new hemoglobin anomaly associated with acute hemolytic episodes with inclusion bodies after sulfonamide therapy. 61
13895148 1962
27
[Hemoglobin-Zurich syndrome]. 61
13895149 1961
28
A new abnormal human hemoglobin-Hb: Zurich. 61
13716725 1961

Variations for Hemoglobin Zurich

ClinVar genetic disease variations for Hemoglobin Zurich:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 LOC106099062 , HBB , LOC107133510 NM_000518.4(HBB):c.191A>G (p.His64Arg) SNV other 15400 rs33985544 GRCh37: 11:5247931-5247931
GRCh38: 11:5226701-5226701

Expression for Hemoglobin Zurich

Search GEO for disease gene expression data for Hemoglobin Zurich.

Pathways for Hemoglobin Zurich

GO Terms for Hemoglobin Zurich

Cellular components related to Hemoglobin Zurich according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.26 HBB HBA2
2 endocytic vesicle lumen GO:0071682 9.16 HBB HBA2
3 hemoglobin complex GO:0005833 8.96 HBB HBA2
4 haptoglobin-hemoglobin complex GO:0031838 8.62 HBB HBA2

Biological processes related to Hemoglobin Zurich according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.4 HBB HBA2
2 cellular oxidant detoxification GO:0098869 9.37 HBB HBA2
3 response to hydrogen peroxide GO:0042542 9.32 HBB HBA2
4 positive regulation of cell death GO:0010942 9.26 HBB HBA2
5 bicarbonate transport GO:0015701 9.16 HBB HBA2
6 hydrogen peroxide catabolic process GO:0042744 8.96 HBB HBA2
7 oxygen transport GO:0015671 8.62 HBB HBA2

Molecular functions related to Hemoglobin Zurich according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.37 HBB HBA2
2 peroxidase activity GO:0004601 9.32 HBB HBA2
3 oxygen binding GO:0019825 9.26 HBB HBA2
4 oxygen carrier activity GO:0005344 9.16 HBB HBA2
5 organic acid binding GO:0043177 8.96 HBB HBA2
6 haptoglobin binding GO:0031720 8.62 HBB HBA2

Sources for Hemoglobin Zurich

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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