MCID: HMG010
MIFTS: 30

Hemoglobinemia

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Hemoglobinemia

MalaCards integrated aliases for Hemoglobinemia:

Name: Hemoglobinemia 53 55 73
Haemoglobinemia 53

Classifications:



External Ids:

UMLS 73 C0235573

Summaries for Hemoglobinemia

MalaCards based summary : Hemoglobinemia, also known as haemoglobinemia, is related to hemolytic anemia and hemoglobinuria. An important gene associated with Hemoglobinemia is HP (Haptoglobin), and among its related pathways/superpathways is Binding and Uptake of Ligands by Scavenger Receptors. The drugs Diclofenac and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and prostate.

Wikipedia : 76 Hemoglobinemia (British Haemoglobinaemia) is a medical condition in which there is an excess of... more...

Related Diseases for Hemoglobinemia

Diseases related to Hemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 hemolytic anemia 28.9 HBB HP
2 hemoglobinuria 10.3
3 prostatitis 10.0
4 purpura 10.0
5 glucosephosphate dehydrogenase deficiency 9.8 HBB HP
6 thrombocytopenic purpura, autoimmune 9.8
7 anemia, autoimmune hemolytic 9.8
8 sickle cell anemia 9.8
9 beta-thalassemia 9.8
10 burns 9.8
11 thalassemia 9.8
12 hypophosphatemia 9.8
13 disseminated intravascular coagulation 9.8
14 ischemia 9.8
15 vein of galen aneurysm 9.8
16 aneurysm 9.8
17 hypoxia 9.8
18 hemoglobinopathy 9.8 HBB HP
19 congenital hemolytic anemia 9.7 HBB HP
20 plasmodium falciparum malaria 9.7 HBB HP
21 alpha-thalassemia 9.6 HBB HP
22 deficiency anemia 9.5 HBB HP
23 hemochromatosis, type 1 8.8 B2M HBB HP

Graphical network of the top 20 diseases related to Hemoglobinemia:



Diseases related to Hemoglobinemia

Symptoms & Phenotypes for Hemoglobinemia

Drugs & Therapeutics for Hemoglobinemia

Drugs for Hemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2 Analgesics Phase 4
3 Cyclooxygenase Inhibitors Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Peripheral Nervous System Agents Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Antirheumatic Agents Phase 4
9
Sulfamethoxazole Approved Phase 3 723-46-6 5329
10
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
11
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
12
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
13
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
14
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
16 Renal Agents Phase 3
17 Folic Acid Antagonists Phase 3
18 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
19 Anti-Bacterial Agents Phase 3
20 Vitamin B Complex Phase 3
21 Fanasil, pyrimethamine drug combination Phase 3
22 Anti-Infective Agents Phase 3
23 Antiparasitic Agents Phase 3
24 Antiprotozoal Agents Phase 3
25 Antimalarials Phase 3
26 Angiogenesis Inhibitors Phase 2, Phase 3
27 Angiogenesis Modulating Agents Phase 2, Phase 3
28 Folate Nutraceutical Phase 3
29 Vitamin B9 Nutraceutical Phase 3
30 Vaccines
31 Calamus Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Non Steroidal Anti Inflammatory Treatment for Post Operative Pericardial Effusion Completed NCT00247052 Phase 4 diclofenac;diclofenac;matching placebo
2 Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum Unknown status NCT01746199 Phase 3 cotrimoxazole daily prophylaxis;sulphadoxine-pyrimethamine
3 Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Terminated NCT02106520 Phase 2, Phase 3 Bevacizumab;placebo
4 Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal Completed NCT01553552
5 The Effect of Citrate Dialysate on Clot Formation and Anemia in Hemodialysis Patients Completed NCT03470727 Not Applicable
6 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers Completed NCT01673412 Not Applicable
7 The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill Recruiting NCT03138200 Not Applicable
8 Prevention of Maternal Hypothermia After Scheduled Caesarean Section Using Active Intravenous Warming Not yet recruiting NCT03581721 Not Applicable

Search NIH Clinical Center for Hemoglobinemia

Genetic Tests for Hemoglobinemia

Anatomical Context for Hemoglobinemia

MalaCards organs/tissues related to Hemoglobinemia:

41
Lung, Kidney, Prostate, Spleen, Skin

Publications for Hemoglobinemia

Articles related to Hemoglobinemia:

(show all 50)
# Title Authors Year
1
Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia. ( 24489894 )
2014
2
Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. ( 21334433 )
2011
3
Renal impairment, hemoglobinuria, and hemoglobinemia among patients with idiopathic thrombocytopenic purpura. ( 21786287 )
2011
4
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. ( 15878975 )
2005
5
Unstable hemoglobinemia, Hb Buenos Aires, Bryn Mawr, followed up for eighteen years. ( 15717496 )
2004
6
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. ( 10753830 )
2000
7
Hypophysectomy, high tumor necrosis factor levels, and hemoglobinemia in lethal endotoxemic shock. ( 9872677 )
1998
8
Hemoglobinemia and hemoglobinuria complicating concomitant use of a white cell filter and a pressure infusion device. ( 7825215 )
1995
9
Bovine postparturient hemoglobinemia: hypophosphatemia and metabolic disorder in red blood cells. ( 3631722 )
1987
10
Hemoglobinemia and renal failure from an intracerebral hematoma simulating a vein of Galen aneurysm. ( 3614590 )
1987
11
An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. ( 6438912 )
1984
12
Oxygen toxicity and hemoglobinemia in subjects from a highly polluted town. ( 6830313 )
1983
13
Hypoxia-induced hemoglobinemia: hypoxic threshold and pathogenic mechanism. ( 7461040 )
1980
14
Hemoglobinemia in mice exposed to high altitude. ( 572040 )
1979
15
Hemoglobinemia in rats exposed to high altitude is not due to an overload of catabolic mechanisms. ( 420674 )
1979
16
The experimental study on the mechanism of hemolysis on paroxysmal hemoglobinemia and hemoglobinuria in calves due to excessive water intake. ( 522335 )
1979
17
Hemoglobinemia in rats exposed to high altitude. ( 658174 )
1978
18
Letter: Coagulation studies during experimental hemoglobinemia. ( 989124 )
1976
19
Coagulation changes in baboons during acute experimental hemoglobinemia and dextran infusion. ( 804256 )
1975
20
Hemoglobinemia in heroin overdose patients. ( 1212878 )
1975
21
Coagulation studies during experimental hemoglobinemia in humans. ( 1120740 )
1975
22
Coagulation studies and correlative histology during experimental hemoglobinemia in rabbits. ( 4814901 )
1974
23
Autoimmune hemolytic anemia with hemoglobinemia and hemoglobinuria in the absence of a demonstrable hemolysin or complement-binding antibody. ( 5766098 )
1969
24
Autoradiographic demonstration of hemoglobin in lysosomes of rabbit proximal tubule cells during experimental hemoglobinemia. ( 5715761 )
1968
25
The effects of acut intravascular hemolysis on coagulation and fibrinolysis. II. March hemoglobinemia and hemoglobinuria. ( 5670600 )
1968
26
The effects of acute intravascular hemolysis on coagulation and fibrinolysis. 3. Hemoglobinemia casused by ingestion of strong acids. ( 5670601 )
1968
27
The renal lesion associated with hemoglobinemia: a study of the pathogenesis of the excretory defect in the rat. ( 6023773 )
1967
28
The renal lesion associated with hemoglobinemia. II. Its structural characteristics in the rat. ( 5937061 )
1966
29
The renal lesion associated with hemoglobinemia. I. Its production and functional evolution in the rat. ( 5937060 )
1966
30
CONTROLLER-GENE DISEASES: THE OPERON MODEL AS APPLIED TO BETA-THALASSEMIA, FAMILIAL FETAL HEMOGLOBINEMIA AND THE NORMAL SWITCH FROM THE PRODUCTION OF FETAL HEMOGLOBIN TO THAT OF ADULT HEMOGLOBIN. ( 14149956 )
1964
31
The renal excretion of hemoglobin in sickle cell anemia, with observations on spontaneously occurring hemoglobinemia and methemalbuminemia. ( 14462673 )
1962
32
The role of acid hematin in the development of acute renal failure following hemoglobinemia. ( 13762779 )
1961
33
Fetomaternal ABO incompatibility: intravascular hemolysis, fetal hemoglobinemia, and fibrinogenopenia in maternal circulation. ( 13745908 )
1961
34
Experimental studies in hemoglobinuric nephrosis. Part 3. The effect of acute hemolytic anemia (hemoglobinemia) combined with ten minutes' unilateral renal ischemia on the morphology and function of the rabbit's kidneys. ( 13821371 )
1959
35
Experimental studies in hemoglobinuric nephrosis. II. The enhanced effect on the kidneys of glycerol-induced hemoglobinemia combined with unilateral nephrectomy. ( 13669985 )
1959
36
Studies on the serum haptoglobin level in hemoglobinemia and its influence on renal excretion of hemoglobin. ( 13436506 )
1957
37
Transient hemoglobinemia associated with hemoglobinuria and methemalbuminemia in the neonatal period. ( 13326382 )
1956
38
The relationship of thermally induced hemoglobinemia to volume of skin burn. ( 13337619 )
1956
39
The heat factor as a cause of hemoglobinemia in transurethral resections. ( 13000964 )
1953
40
The significance of hemoglobinemia and associated hemosiderinuria, with particular reference to various types of hemolytic anemia. ( 14889070 )
1951
41
Hemoglobinemia and lower nephron nephrosis following transurethral prostatic surgery. ( 14841851 )
1951
42
Hemoglobinemia and hemoglobinuric nephrosis complicating transurethral resection of the prostate. ( 18139135 )
1949
43
Studies of hemoglobinemia and its effect on kidney excretion. ( 20342795 )
1947
44
Blood transfusion studies; the relationship of hemoglobinemia and of the pH of the urine to renal damage produced by injection of hemoglobin solutions into dogs. ( 20289794 )
1947
45
Hemoglobinemia accompanying transurethral resection of the prostate. ( 20259951 )
1947
46
Hemoglobinemia and the hemoglobinurias. ( 21003944 )
1945
47
Hemoglobinemia and the hemoglobinurias. ( 21007432 )
1945
48
PHYSIOLOGICAL INTRAVASCULAR HEMOLYSIS OF EXERCISE. HEMOGLOBINEMIA AND HEMOGLOBINURIA FOLLOWING CROSS-COUNTRY RUNS. ( 16695071 )
1943
49
STUDIES OF HEMOGLOBINEMIA AND HEMOGLOBINURIA PRODUCED IN MAN BY INTRAVENOUS INJECTION OF HEMOGLOBIN SOLUTIONS. ( 16694823 )
1941
50
THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : II. THE RELATION OF HEMOGLOBINEMIA TO HEMOGLOBINURIA AND JAUNDICE IN NORMAL AND SPLENECTOMIZED ANIMALS. ( 19867581 )
1912

Variations for Hemoglobinemia

Expression for Hemoglobinemia

Search GEO for disease gene expression data for Hemoglobinemia.

Pathways for Hemoglobinemia

Pathways related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.64 HBB HP

GO Terms for Hemoglobinemia

Cellular components related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.58 B2M HBB HP
2 extracellular space GO:0005615 9.54 B2M HBB HP
3 blood microparticle GO:0072562 9.32 HBB HP
4 specific granule lumen GO:0035580 9.26 B2M HP
5 endocytic vesicle lumen GO:0071682 9.16 HBB HP
6 haptoglobin-hemoglobin complex GO:0031838 8.96 HBB HP
7 tertiary granule lumen GO:1904724 8.8 B2M HBB HP

Biological processes related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.32 HBB HP
2 cellular oxidant detoxification GO:0098869 9.26 HBB HP
3 response to hydrogen peroxide GO:0042542 9.16 HBB HP
4 positive regulation of cell death GO:0010942 8.96 HBB HP
5 neutrophil degranulation GO:0043312 8.8 B2M HBB HP

Molecular functions related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin binding GO:0030492 8.62 HBB HP

Sources for Hemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....