MCID: HMG010
MIFTS: 30

Hemoglobinemia

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hemoglobinemia

MalaCards integrated aliases for Hemoglobinemia:

Name: Hemoglobinemia 54 56 74
Haemoglobinemia 54

Classifications:



External Ids:

UMLS 74 C0235573

Summaries for Hemoglobinemia

MalaCards based summary : Hemoglobinemia, also known as haemoglobinemia, is related to hemolytic anemia and hemoglobinuria. An important gene associated with Hemoglobinemia is HP (Haptoglobin), and among its related pathways/superpathways is Binding and Uptake of Ligands by Scavenger Receptors. The drugs Diclofenac and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and skin.

Wikipedia : 77 Hemoglobinemia (British Haemoglobinaemia) is a medical condition in which there is an excess of... more...

Related Diseases for Hemoglobinemia

Diseases related to Hemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 hemolytic anemia 30.1 HBB HP
2 hemoglobinuria 10.5
3 purpura 10.2
4 thrombocytopenic purpura, autoimmune 10.0
5 anemia, autoimmune hemolytic 10.0
6 sickle cell anemia 10.0
7 beta-thalassemia 10.0
8 thalassemia 10.0
9 hypophosphatemia 10.0
10 disseminated intravascular coagulation 10.0
11 ischemia 10.0
12 vein of galen aneurysm 10.0
13 hypoxia 10.0
14 glucosephosphate dehydrogenase deficiency 9.9 HBB HP
15 iron overload in africa 9.9 HBB HP
16 methemoglobinemia 9.9 HBB HP
17 hemoglobinopathy 9.9 HBB HP
18 congenital hemolytic anemia 9.9 HBB HP
19 plasmodium falciparum malaria 9.8 HBB HP
20 alpha-thalassemia 9.8 HBB HP
21 deficiency anemia 9.7 HBB HP
22 hemochromatosis, type 1 9.4 B2M HP

Graphical network of the top 20 diseases related to Hemoglobinemia:



Diseases related to Hemoglobinemia

Symptoms & Phenotypes for Hemoglobinemia

Drugs & Therapeutics for Hemoglobinemia

Drugs for Hemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2 Anti-Inflammatory Agents Phase 4
3 Analgesics Phase 4
4 Antirheumatic Agents Phase 4
5 Cyclooxygenase Inhibitors Phase 4
6 Anti-Inflammatory Agents, Non-Steroidal Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Peripheral Nervous System Agents Phase 4
9
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
10
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
11
Sulfamethoxazole Approved Phase 3 723-46-6 5329
12
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
13
leucovorin Approved Phase 3 58-05-9 143 6006
14
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
16 Antiparasitic Agents Phase 3
17 Antimalarials Phase 3
18 Anti-Infective Agents Phase 3
19 Anti-Infective Agents, Urinary Phase 3
20 Anti-Bacterial Agents Phase 3
21 Vitamin B Complex Phase 3
22 Fanasil, pyrimethamine drug combination Phase 3
23 Antiprotozoal Agents Phase 3
24 Folate Phase 3
25 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
26 Vitamin B9 Phase 3
27 Folic Acid Antagonists Phase 3
28 Renal Agents Phase 3
29 Angiogenesis Inhibitors Phase 2, Phase 3
30 Angiogenesis Modulating Agents Phase 2, Phase 3
31 Antineoplastic Agents, Immunological Phase 2, Phase 3
32
Heparin Approved, Investigational Not Applicable 9005-49-6 46507594 772
33
Sodium Citrate Approved, Investigational Not Applicable 68-04-2
34
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
35
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
36 Calamus Not Applicable
37 Vaccines
38 Anticoagulants Not Applicable
39 Pharmaceutical Solutions Not Applicable
40 Chelating Agents Not Applicable
41 Calcium, Dietary Not Applicable
42 calcium heparin Not Applicable
43 Citrate Not Applicable
44 Dialysis Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Non Steroidal Anti Inflammatory Treatment for Post Operative Pericardial Effusion Completed NCT00247052 Phase 4 diclofenac;diclofenac;matching placebo
2 Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum Unknown status NCT01746199 Phase 3 cotrimoxazole daily prophylaxis;sulphadoxine-pyrimethamine
3 Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Terminated NCT02106520 Phase 2, Phase 3 Bevacizumab;placebo
4 The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill Unknown status NCT03138200 Not Applicable
5 Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal Completed NCT01553552
6 The Effect of Citrate Dialysate on Clot Formation and Anemia in Hemodialysis Patients Completed NCT03470727 Not Applicable
7 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers Completed NCT01673412 Not Applicable
8 Efficiency of Lina LibrataTM System Recruiting NCT03670680 Not Applicable
9 Prevention of Maternal Hypothermia After Scheduled Caesarean Section Using Active Intravenous Warming Suspended NCT03581721 Not Applicable

Search NIH Clinical Center for Hemoglobinemia

Genetic Tests for Hemoglobinemia

Anatomical Context for Hemoglobinemia

MalaCards organs/tissues related to Hemoglobinemia:

42
Kidney, Prostate, Skin, Spleen

Publications for Hemoglobinemia

Articles related to Hemoglobinemia:

(show top 50) (show all 51)
# Title Authors Year
1
Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia. ( 24489894 )
2014
2
Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. ( 21334433 )
2011
3
Renal impairment, hemoglobinuria, and hemoglobinemia among patients with idiopathic thrombocytopenic purpura. ( 21786287 )
2011
4
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. ( 15878975 )
2005
5
Unstable hemoglobinemia, Hb Buenos Aires, Bryn Mawr, followed up for eighteen years. ( 15717496 )
2004
6
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. ( 10753830 )
2000
7
Hypophysectomy, high tumor necrosis factor levels, and hemoglobinemia in lethal endotoxemic shock. ( 9872677 )
1998
8
Hemoglobinemia and hemoglobinuria complicating concomitant use of a white cell filter and a pressure infusion device. ( 7825215 )
1995
9
Hemoglobinemia and renal failure from an intracerebral hematoma simulating a vein of Galen aneurysm. ( 3614590 )
1987
10
Bovine postparturient hemoglobinemia: hypophosphatemia and metabolic disorder in red blood cells. ( 3631722 )
1987
11
An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. ( 6438912 )
1984
12
Oxygen toxicity and hemoglobinemia in subjects from a highly polluted town. ( 6830313 )
1983
13
Hypoxia-induced hemoglobinemia: hypoxic threshold and pathogenic mechanism. ( 7461040 )
1980
14
Hemoglobinemia in rats exposed to high altitude is not due to an overload of catabolic mechanisms. ( 420674 )
1979
15
The experimental study on the mechanism of hemolysis on paroxysmal hemoglobinemia and hemoglobinuria in calves due to excessive water intake. ( 522335 )
1979
16
Hemoglobinemia in mice exposed to high altitude. ( 572040 )
1979
17
Hemoglobinemia in rats exposed to high altitude. ( 658174 )
1978
18
Letter: Coagulation studies during experimental hemoglobinemia. ( 989124 )
1976
19
Coagulation changes in baboons during acute experimental hemoglobinemia and dextran infusion. ( 804256 )
1975
20
Coagulation studies during experimental hemoglobinemia in humans. ( 1120740 )
1975
21
Hemoglobinemia in heroin overdose patients. ( 1212878 )
1975
22
Coagulation studies and correlative histology during experimental hemoglobinemia in rabbits. ( 4814901 )
1974
23
Autoimmune hemolytic anemia with hemoglobinemia and hemoglobinuria in the absence of a demonstrable hemolysin or complement-binding antibody. ( 5766098 )
1969
24
The effects of acut intravascular hemolysis on coagulation and fibrinolysis. II. March hemoglobinemia and hemoglobinuria. ( 5670600 )
1968
25
The effects of acute intravascular hemolysis on coagulation and fibrinolysis. 3. Hemoglobinemia casused by ingestion of strong acids. ( 5670601 )
1968
26
Autoradiographic demonstration of hemoglobin in lysosomes of rabbit proximal tubule cells during experimental hemoglobinemia. ( 5715761 )
1968
27
The renal lesion associated with hemoglobinemia: a study of the pathogenesis of the excretory defect in the rat. ( 6023773 )
1967
28
The renal lesion associated with hemoglobinemia. I. Its production and functional evolution in the rat. ( 5937060 )
1966
29
The renal lesion associated with hemoglobinemia. II. Its structural characteristics in the rat. ( 5937061 )
1966
30
Hemoglobinemia and the kidney. ( 5952424 )
1966
31
CONTROLLER-GENE DISEASES: THE OPERON MODEL AS APPLIED TO BETA-THALASSEMIA, FAMILIAL FETAL HEMOGLOBINEMIA AND THE NORMAL SWITCH FROM THE PRODUCTION OF FETAL HEMOGLOBIN TO THAT OF ADULT HEMOGLOBIN. ( 14149956 )
1964
32
The renal excretion of hemoglobin in sickle cell anemia, with observations on spontaneously occurring hemoglobinemia and methemalbuminemia. ( 14462673 )
1962
33
Fetomaternal ABO incompatibility: intravascular hemolysis, fetal hemoglobinemia, and fibrinogenopenia in maternal circulation. ( 13745908 )
1961
34
The role of acid hematin in the development of acute renal failure following hemoglobinemia. ( 13762779 )
1961
35
Experimental studies in hemoglobinuric nephrosis. II. The enhanced effect on the kidneys of glycerol-induced hemoglobinemia combined with unilateral nephrectomy. ( 13669985 )
1959
36
Experimental studies in hemoglobinuric nephrosis. Part 3. The effect of acute hemolytic anemia (hemoglobinemia) combined with ten minutes' unilateral renal ischemia on the morphology and function of the rabbit's kidneys. ( 13821371 )
1959
37
Studies on the serum haptoglobin level in hemoglobinemia and its influence on renal excretion of hemoglobin. ( 13436506 )
1957
38
Transient hemoglobinemia associated with hemoglobinuria and methemalbuminemia in the neonatal period. ( 13326382 )
1956
39
The relationship of thermally induced hemoglobinemia to volume of skin burn. ( 13337619 )
1956
40
The heat factor as a cause of hemoglobinemia in transurethral resections. ( 13000964 )
1953
41
Hemoglobinemia and lower nephron nephrosis following transurethral prostatic surgery. ( 14841851 )
1951
42
The significance of hemoglobinemia and associated hemosiderinuria, with particular reference to various types of hemolytic anemia. ( 14889070 )
1951
43
Hemoglobinemia and hemoglobinuric nephrosis complicating transurethral resection of the prostate. ( 18139135 )
1949
44
Hemoglobinemia accompanying transurethral resection of the prostate. ( 20259951 )
1947
45
Blood transfusion studies; the relationship of hemoglobinemia and of the pH of the urine to renal damage produced by injection of hemoglobin solutions into dogs. ( 20289794 )
1947
46
Studies of hemoglobinemia and its effect on kidney excretion. ( 20342795 )
1947
47
Hemoglobinemia and the hemoglobinurias. ( 21003944 )
1945
48
Hemoglobinemia and the hemoglobinurias. ( 21007432 )
1945
49
PHYSIOLOGICAL INTRAVASCULAR HEMOLYSIS OF EXERCISE. HEMOGLOBINEMIA AND HEMOGLOBINURIA FOLLOWING CROSS-COUNTRY RUNS. ( 16695071 )
1943
50
STUDIES OF HEMOGLOBINEMIA AND HEMOGLOBINURIA PRODUCED IN MAN BY INTRAVENOUS INJECTION OF HEMOGLOBIN SOLUTIONS. ( 16694823 )
1941

Variations for Hemoglobinemia

Expression for Hemoglobinemia

Search GEO for disease gene expression data for Hemoglobinemia.

Pathways for Hemoglobinemia

Pathways related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.64 HBB HP

GO Terms for Hemoglobinemia

Cellular components related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 B2M HBB HP
2 extracellular exosome GO:0070062 9.58 B2M HBB HP
3 extracellular space GO:0005615 9.54 B2M HBB HP
4 blood microparticle GO:0072562 9.32 HBB HP
5 specific granule lumen GO:0035580 9.26 B2M HP
6 endocytic vesicle lumen GO:0071682 9.16 HBB HP
7 haptoglobin-hemoglobin complex GO:0031838 8.96 HBB HP
8 tertiary granule lumen GO:1904724 8.8 B2M HBB HP

Biological processes related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.32 HBB HP
2 cellular oxidant detoxification GO:0098869 9.26 HBB HP
3 response to hydrogen peroxide GO:0042542 9.16 HBB HP
4 positive regulation of cell death GO:0010942 8.96 HBB HP
5 neutrophil degranulation GO:0043312 8.8 B2M HBB HP

Molecular functions related to Hemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin binding GO:0030492 8.62 HBB HP

Sources for Hemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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