MCID: HML002
MIFTS: 62

Hemolytic Anemia

Categories: Blood diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Hemolytic Anemia

MalaCards integrated aliases for Hemolytic Anemia:

Name: Hemolytic Anemia 12 29 6 15 37 62 17
Anemia, Hemolytic 44 39 70
Anemia Hemolytic 12 54

Classifications:



External Ids:

Disease Ontology 12 DOID:583
MeSH 44 D000743
NCIt 50 C34376
SNOMED-CT 67 61261009
ICD10 32 D55-D59
UMLS 70 C0002878

Summaries for Hemolytic Anemia

PubMed Health : 62 About hemolytic anemia: Hemolytic anemia (HEE-moh-lit-ick uh-NEE-me-uh) is a condition in which red blood cells are destroyed and removed from the bloodstream before their normal lifespan is over. Red blood cells are disc-shaped and look like doughnuts without holes in the center. These cells carry oxygen to your body. They also remove carbon dioxide (a waste product) from your body. Red blood cells are made in the bone marrow—a sponge-like tissue inside the bones. They live for about 120 days in the bloodstream and then die. White blood cells and platelets (PLATE-lets) also are made in the bone marrow. White blood cells help fight infections. Platelets stick together to seal small cuts or breaks on blood vessel walls and stop bleeding. When blood cells die, the body's bone marrow makes more blood cells to replace them. However, in hemolytic anemia, the bone marrow can't make red blood cells fast enough to meet the body's needs. Hemolytic anemia can lead to many health problems, such as fatigue (tiredness), pain, irregular heartbeats called arrhythmias (ah-RITH-me-ahs), an enlarged heart, and heart failure.

MalaCards based summary : Hemolytic Anemia, also known as anemia, hemolytic, is related to congenital hemolytic anemia and hereditary spherocytosis, and has symptoms including icterus An important gene associated with Hemolytic Anemia is SPTB (Spectrin Beta, Erythrocytic), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Tacrolimus and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and spleen, and related phenotypes are Decreased simian virus 40 (SV40) infection and hematopoietic system

Wikipedia : 73 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

Related Diseases for Hemolytic Anemia

Diseases in the Hemolytic Anemia family:

Anemia, Autoimmune Hemolytic Congenital Hemolytic Anemia
Rare Acquired Hemolytic Anemia Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction
Hemolytic Anemia Due to an Erythrocyte Nucleotide Metabolism Disorder Hemolytic Anemia Due to a Disorder of Glycolytic Enzymes
Hemolytic Anemia Due to Hexose Monophosphate Shunt and Glutathione Metabolism Anomalies Rare Hemolytic Anemia

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1037)
# Related Disease Score Top Affiliating Genes
1 congenital hemolytic anemia 33.5 SPTB SPTA1 SLC4A1 PKLR HBB GPI
2 hereditary spherocytosis 33.4 SPTB SPTA1 SLC4A1 RHAG PKLR HBB
3 glucosephosphate dehydrogenase deficiency 33.3 SLC4A1 PKLR HBB G6PD
4 congenital nonspherocytic hemolytic anemia 33.2 PKLR PGK1 NT5C3A GPI G6PD
5 pyruvate kinase deficiency of red cells 33.2 PKLR G6PD
6 deficiency anemia 33.1 SPTB SPTA1 SLC4A1 PKLR PGK1 LOC107133510
7 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 33.0 SPTA1 SLC4A1 RHAG EPB42
8 glutamate-cysteine ligase deficiency 33.0 SPTA1 SLC4A1 RHAG PKLR GCLC
9 heinz body anemias 32.7 LOC107133510 LOC106099062 HBB
10 pyropoikilocytosis, hereditary 32.7 SPTB SPTA1
11 hereditary elliptocytosis 32.5 SPTB SPTA1 SLC4A1 RHAG HBB G6PD
12 glutathione synthetase deficiency 32.5 GSS G6PD
13 hemoglobin zurich 32.3 LOC107133510 LOC106099062 HBB
14 spherocytosis, type 2 32.3 SPTB SPTA1 HBB
15 cryohydrocytosis 32.3 SLC4A1 RHAG
16 thalassemia 32.0 LOC107133510 LOC106099062 HBB G6PD
17 methemoglobinemia 31.8 LOC107133510 LOC106099062 HBB G6PD
18 hemoglobinopathy 31.7 LOC107133510 LOC106099062 HBB G6PD
19 sickle cell disease 31.6 LOC107133510 LOC106099062 HBB G6PD
20 beta-thalassemia 31.6 SPTB SPTA1 SLC4A1 LOC107133510 LOC106099062 HBB
21 neonatal jaundice 31.5 SPTA1 PKLR G6PD ADAMTS13
22 glucosephosphate isomerase deficiency 31.5 GPI G6PD
23 sickle cell anemia 31.5 LOC107133510 LOC106099062 HBB G6PD
24 malaria 31.4 SPTA1 SLC4A1 PKLR LOC107133510 LOC106099062 HBB
25 splenic sequestration 31.2 HBB ADAMTS13
26 hereditary stomatocytosis 31.1 SLC4A1 RHAG
27 splenic infarction 31.1 LOC107133510 LOC106099062 HBB
28 beta-thalassemia major 31.0 LOC107133510 LOC106099062 HBB
29 alpha-thalassemia 31.0 LOC107133510 LOC106099062 HBB G6PD
30 beta-thalassemia intermedia 30.9 LOC107133510 LOC106099062 HBB
31 thalassemia minor 30.9 LOC107133510 LOC106099062 HBB
32 hemoglobin c disease 30.8 LOC107133510 LOC106099062 HBB
33 hemoglobin e disease 30.8 LOC107133510 LOC106099062 HBB
34 blood group incompatibility 30.7 SLC4A1 G6PD
35 beta-thalassemia, dominant inclusion body type 30.5 LOC107133510 LOC106099062 HBB
36 hemoglobin h disease 30.5 HBB G6PD AK1
37 fetal hemoglobin quantitative trait locus 1 30.5 LOC107133510 LOC106099062 HBB
38 hemoglobin d disease 30.4 LOC107133510 HBB
39 anemia, autoimmune hemolytic 12.0
40 hemolytic anemia, nonspherocytic, due to hexokinase deficiency 11.7
41 uridine 5-prime monophosphate hydrolase deficiency, hemolytic anemia due to 11.7
42 thrombotic thrombocytopenic purpura, hereditary 11.7
43 gamma-glutamylcysteine synthetase deficiency, hemolytic anemia due to 11.7
44 adenylate kinase deficiency, hemolytic anemia due to 11.7
45 warm antibody hemolytic anemia 11.7
46 glutathione synthetase deficiency of erythrocytes, hemolytic anemia due to 11.7
47 hemolytic anemia, congenital, x-linked 11.6
48 anemia, nonspherocytic hemolytic, due to g6pd deficiency 11.6
49 glut1 deficiency syndrome 2 11.6
50 hemolytic anemia due to glutathione reductase deficiency 11.6

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to Hemolytic Anemia

Symptoms & Phenotypes for Hemolytic Anemia

UMLS symptoms related to Hemolytic Anemia:


icterus

GenomeRNAi Phenotypes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased simian virus 40 (SV40) infection GR00356-A-2 8.32 PGK1

MGI Mouse Phenotypes related to Hemolytic Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 ADAMTS13 ALDOA CD59 EPB42 G6PD GPI
2 homeostasis/metabolism MP:0005376 9.44 ADAMTS13 AK1 CD59 EPB42 G6PD GCLC

Drugs & Therapeutics for Hemolytic Anemia

PubMed Health treatment related to Hemolytic Anemia: 62

Treatments for hemolytic anemia include blood transfusions , medicines, plasmapheresis (PLAZ-meh-feh-RE-sis), surgery , blood and marrow stem cell transplants , and lifestyle changes. People who have mild hemolytic anemia may not need treatment , as long as the condition doesn't worsen. People who have severe hemolytic anemia usually need ongoing treatment. Severe hemolytic anemia can be fatal if it's not properly treated.

Drugs for Hemolytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
2 Immunologic Factors Phase 4
3 Immunosuppressive Agents Phase 4
4 Calcineurin Inhibitors Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
8
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
9
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
10
alemtuzumab Approved, Investigational Phase 2, Phase 3 216503-57-0
11
Ribavirin Approved Phase 3 36791-04-5 37542
12
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
13 Antirheumatic Agents Phase 3
14 Methylprednisolone Acetate Phase 3
15 glucocorticoids Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Anti-Infective Agents Phase 3
19 Antineoplastic Agents, Immunological Phase 2, Phase 3
20 Protective Agents Phase 3
21 Neuroprotective Agents Phase 3
22 Antiviral Agents Phase 3
23 Antimetabolites Phase 3
24 interferons Phase 3
25 Interferon-alpha Phase 3
26 Immunoglobulins Phase 3
27 Antibodies Phase 3
28 Autoantibodies Phase 3
29 pyruvate Phase 3
30 Pharmaceutical Solutions Phase 3
31 Agglutinins Phase 3
32
Levamisole Approved, Investigational, Vet_approved, Withdrawn Phase 2 14769-73-4 26879
33
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
34
Aldesleukin Approved Phase 1, Phase 2 110942-02-4, 85898-30-2
35
Lactitol Approved, Investigational Phase 1, Phase 2 585-86-4 157355
36
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
37
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
38
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
39
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
40
Lenograstim Approved, Investigational Phase 2 135968-09-1
41
Iron Approved Phase 2 7439-89-6 23925 29936
42
Acyclovir Approved Phase 2 59277-89-3 2022
43
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381 214348
44
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
45
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
46
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
47
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
48
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030
49
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
50
Diphenhydramine Approved, Investigational Phase 1, Phase 2 147-24-0, 58-73-1 3100

Interventional clinical trials:

(show top 50) (show all 77)
# Name Status NCT ID Phase Drugs
1 Tacrolimus Treatment for Refractory Autoimmune Cytopenia Recruiting NCT03918265 Phase 4 Tacrolimus
2 Anti-CD20 Antibody Rituximab in Addition to Prednisolone in Treatment of Warm Antibody Related Autoimmune Hemolytic Anemia. A Randomised Danish Multicenter Trial. Completed NCT01134432 Phase 3 prednisolone + mabthera;Prednisolone
3 Rituximab in Adult's Warm Auto-Immune Hemolytic Anemia : a Phase III, Double-bind, Randomised Placebo-controlled Trial Completed NCT01181154 Phase 3 rituximab (Mabthera®);Placebo
4 Low Doses of Alemtuzumab and Rituximab in the Treatment of Refractory Autoimmune Cytopenias Completed NCT00749112 Phase 2, Phase 3 Alemtuzumab, Rituximab
5 An Open-Label Study To Evaluate the Efficacy and Safety of AG-348 in Regularly Transfused Adult Subjects With Pyruvate Kinase (PK) Deficiency Completed NCT03559699 Phase 3 AG-348
6 A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Subjects With Pyruvate Kinase Deficiency Completed NCT03548220 Phase 3 AG-348;Placebo
7 Combination of Alpha Interferon With Long Term Ribavirin Therapy for Patients With Chronic Hepatitis C Completed NCT00001729 Phase 3 Ribavirin
8 A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia Recruiting NCT03764618 Phase 3 Fostamatinib disodium;Placebo
9 Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia: A Multicenter, Randomized, Double-blind, Placebo-controlled Study With a Long-term Open-label Extension Recruiting NCT04119050 Phase 2, Phase 3 M281;Placebo
10 A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia Active, not recruiting NCT04138927 Phase 3 Fostamatinib disodium
11 An Open-Label, Multicenter, Extension Study of AG-348 in Adult Subjects With Pyruvate Kinase Deficiency Previously Enrolled in AG-348 Studies Active, not recruiting NCT03853798 Phase 3 AG-348
12 A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Sutimlimab in Patients With Primary Cold Agglutinin Disease Without a Recent History of Blood Transfusion Active, not recruiting NCT03347422 Phase 3 sutimlimab (BIVV009);placebo
13 A Phase 3, Pivotal, Open-label, Multicenter Study to Assess the Efficacy and Safety of Sutimlimab in Patients With Primary Cold Agglutinin Disease Who Have a Recent History of Blood Transfusion Active, not recruiting NCT03347396 Phase 3 Sutimlimab
14 Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. Unknown status NCT01579110 Phase 2 levamisole;Prednisone
15 Phase II Study of the Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria Unknown status NCT01642979 Phase 2 Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
16 Phase II Study of the Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013) Unknown status NCT01760096 Phase 2 Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
17 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2 prednisone, low dose rituximab
18 " Anemil Trial ": Phase I/II Clinical Trial Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Completed NCT02389231 Phase 1, Phase 2 Interleukine-2
19 The CAD5 Study::Therapy for Chronic Cold Agglutinin Disease: A Prospective, Non-randomized International Multicenter Trial on the Safety and Efficacy of Bendamustine and Rituximab Combination Therapy Completed NCT02689986 Phase 2 Bendamustine, Rituximab
20 CHOP Plus Rituximab (CHOP-R) in Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL) or CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT) Completed NCT00309881 Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
21 Sirolimus for Patients With Chronic and/or Refractory Autoimmune Cytopenias: A Pilot Series Completed NCT00392951 Phase 1, Phase 2 sirolimus
22 Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease Completed NCT00010387 Phase 2 cyclophosphamide;filgrastim
23 Short Course of Bortezomib in Anemic Patients With Refractory Cold Agglutinin Disease Completed NCT01696474 Phase 2 Bortezomib
24 Therapy for Chronic Cold Agglutinin Disease: A Prospective, Non-Randomized Multi-Center Study Demonstrating the Efficacy of Terminal Complement Inhibition in Patients With Cold Agglutinin Disease Using Eculizumab Completed NCT01303952 Phase 2 Eculizumab
25 A Randomized, Open-label, Multi-center, Phase II Study to Evaluate the Safety and Efficacy of Deferasirox (ICL670) 20 mg/kg/Day Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients With Iron Overload From Repeated Blood Transfusions Completed NCT00110617 Phase 2 Deferasirox (ICL670);Deferoxamine (DFO)
26 Therapy for Chronic Cold Agglutinin Disease: A Prospective, Non-randomized International Multicentre Study on the Safety and Efficacy of Rituximab in Combination With Fludarabine. Completed NCT00373594 Phase 2 Rituximab;Fludarabine
27 A Phase 2, Open-Label Study of INCB050465 in Participants With Autoimmune Hemolytic Anemia Recruiting NCT03538041 Phase 2 Parsaclisib
28 An Open, One-arm, Prospective Study of a Single Dose Anti-CD20 Monoclonal Antibody Combined With Bortezomib for Treatment of Relapsed Refractory Autoimmune Hemolytic Anemia Recruiting NCT04083014 Phase 2 combination of a single dose anti-CD20 antibody and bortezomib
29 A Phase 2 Trial of Acalabrutinib for the Treatment of Relapsed/Refractory Autoimmune Hemolytic Anemia Recruiting NCT04657094 Phase 2 Acalabrutinib
30 A Phase II, Single-Center, Open-label Trial to Determine the Safety and Efficacy of Ibrutinib in Refractory/Relapsed Autoimmune Hemolytic Recruiting NCT04398459 Phase 2 Ibrutinib
31 Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia Recruiting NCT00061568 Phase 1, Phase 2 Alemtuzumab;Sirolimus
32 Daily Vitamin D for Sickle-cell Respiratory Complications Recruiting NCT04170348 Phase 2 Daily oral vitamin D3, 3,333 IU;Bolus oral vitamin D3, 100,000 IU;Placebo oral tablet
33 Evaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat Recruiting NCT04610866 Phase 1, Phase 2 Mitapivat
34 A Phase 2, Multi-Center, Open Label, Simon Two-Stage Study to Evaluate the Safety and Efficacy of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia Active, not recruiting NCT02612558 Phase 2 Fostamatinib 150 mg bid
35 Ibrutinib in Steroid Refractory Autoimmune Hemolytic Anemia: ELaboration of Treatment Approach Active, not recruiting NCT03827603 Phase 2 Ibrutinib
36 An Open Label, Prospective, Study to Assess the Safety, Tolerability, Efficacy and Pharmacokinetics of APL-2 in Patients With Warm Type Autoimmune Hemolytic Anemia (wAIHA) or Cold Agglutinin Disease (CAD) Active, not recruiting NCT03226678 Phase 2 APL-2
37 A Phase 2, Open Label, Randomized, Dose Ranging, Safety, Efficacy, Pharmacokinetic and Pharmacodynamic Study of AG-348 in Adult Patients With Pyruvate Kinase Deficiency Active, not recruiting NCT02476916 Phase 2 AG-348
38 A Phase 2, Open-Label, Repeat Dose Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Intravenous ANX005 in Subjects With Warm Autoimmune Hemolytic Anemia (wAIHA) Not yet recruiting NCT04691570 Phase 2 ANX005
39 A Multicenter, Open-label, Non-randomized, Phase 1b/2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Subcutaneous Isatuximab in Adults With Warm Autoimmune Hemolytic Anemia Not yet recruiting NCT04661033 Phase 1, Phase 2 Isatuximab SAR650984;Diphenhydramine;Famotidine;Acetaminophen;Montelukast
40 An Explananatory, Proof-of-concept Study of Senicapoc in Patients With Familial Dehydrated Stomatocytosis Caused by the V282M Mutation in the Gardos (KCNN4) Channel Not yet recruiting NCT04372498 Phase 1, Phase 2 Senicapoc (synonyms: ICA-17043; 2,2-bis-(4-fluorophenyl)-2-phenylacetamide)
41 A Phase 2, Multicenter, Non-Randomized, Open-Label Study of RVT-1401 for the Treatment of Patients With Warm Autoimmune Hemolytic Anemia Suspended NCT04253236 Phase 2 RVT-1401 680 mg/weekly;RVT-1401 340 mg/weekly
42 A Phase 1B/2, Multicenter, Open-Label, Safety, Tolerability, and Activity Study of SYNT001 in Patients With Warm Autoimmune Hemolytic Anemia (WAIHA) Terminated NCT03075878 Phase 1, Phase 2 ALXN1830
43 A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Study of ALXN1830 in Patients With Warm Autoimmune Hemolytic Anemia Withdrawn NCT04256148 Phase 2
44 A Phase 2 Randomized, Dose-blind, Multicenter Study to Evaluate the Safety and Efficacy of KZR-616 in the Treatment of Patients With Autoimmune Hemolytic Anemia (AIHA) and Immune Thrombocytopenia (ITP) Withdrawn NCT04039477 Phase 2 KZR-616
45 A Prospective Open-label Trial to Assess the Efficacy and Safety of Ixazomib and Dexamethasone in Patients With Refractory Autoimmune Cytopenia Withdrawn NCT03965624 Phase 2 Ninlaro
46 High-Dose Cyclophosphamide With CD34+ Selected Autologous Hematopoietic Cell Support for Treatment of Refractory Chronic Autoimmune Thrombocytopenia Completed NCT00001630 Phase 1
47 Gene Therapy for Pyruvate Kinase Deficiency (PKD): A Phase I Clinical Trial to Evaluate the Safety of the Infusion of Autologous CD34+ Cells Transduced With a Lentiviral Vector Carrying the Codon Optimized Red Cell Pyruvate Kinase (coRPK) Gene in Adult and Pediatric Subjects With PKD Recruiting NCT04105166 Phase 1
48 A Multicenter, Phase 1b, Open Label, Nonrandomized, Single Dose Study Evaluating the Safety, Tolerability and Activity of BIVV020 in Adults With Cold Agglutinin Disease Recruiting NCT04269551 Phase 1 BIVV020
49 An Open Label, Long Term, Safety and Tolerability Study of Patients With Cold Agglutinin Disease Previously Treated With BIVV020 Recruiting NCT04802057 Phase 1 BIVV020
50 Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement-mediated Disorders. A Single/Multiple Ascending Dose Phase 1 Study. Active, not recruiting NCT02502903 Phase 1 BIV009

Search NIH Clinical Center for Hemolytic Anemia

Inferred drug relations via UMLS 70 / NDF-RT 51 :


alpha-Tocopherol Acetate
d-alpha-Tocopheryl Acetate
dl-alpha tocopheryl acetate
Tocopherol Acetate
TOCOPHEROL,DL-ALPHA
Tocopherols
TOCOPHERYL ACID SUCCINATE
TOCOPHERYL ACID SUCCINATE,D-ALPHA
Vitamin E

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: anemia, hemolytic

Genetic Tests for Hemolytic Anemia

Genetic tests related to Hemolytic Anemia:

# Genetic test Affiliating Genes
1 Hemolytic Anemia 29

Anatomical Context for Hemolytic Anemia

MalaCards organs/tissues related to Hemolytic Anemia:

40
Bone Marrow, Bone, Spleen, Heart, Liver, Myeloid, Endothelial

Publications for Hemolytic Anemia

Articles related to Hemolytic Anemia:

(show top 50) (show all 13634)
# Title Authors PMID Year
1
Hemoglobin Sendagi (beta 42 Phe----Val): a new unstable hemoglobin variant having an amino acid substitution at CD1 of the beta-chain. 6 61
3781864 1986
2
Hemoglobin Louisville (beta-42 (CD1) phe-leu): an unstable variant causing mild hemolytic anemia. 6 61
5096522 1971
3
Whole-genome sequencing of patients with rare diseases in a national health system. 6
32581362 2020
4
Hb south Milwaukee [beta 105 (G7) Leu----Phe]: a newly-identified hemoglobin variant with high oxygen affinity. 6
2363414 1990
5
A new Spanish family with Hb Louisville. 6
2705488 1989
6
Haemoglobin Buccureşti 42(CD1) Phe-Leu, a cause of unstable haemoglobin haemolytic anaemia. 6
5133275 1971
7
Gastrointestinal and hepatic complications of sickle cell disease. 54 61
20215064 2010
8
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt. 54 61
20426517 2010
9
Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole. 61 54
20065266 2010
10
Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians. 61 54
20007901 2009
11
Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. 54 61
19755962 2009
12
Adenosine deaminase-adenosine pathway in hemolysis-associated pulmonary hypertension. 54 61
19237250 2009
13
Early erythropoietin reduced the need for red blood cell transfusion in childhood hemolytic uremic syndrome: a randomized prospective pilot trial. 61 54
19085014 2009
14
Sickle cell anemia in northern Israel: screening and prevention. 61 54
19603597 2009
15
A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency. Vicia sativa (Vetch). 54 61
19198723 2009
16
Brucellosis triggering hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency. 54 61
19494543 2009
17
A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica. 54 61
19340395 2009
18
A novel G6PD mutation leading to chronic hemolytic anemia. 61 54
18677765 2008
19
Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia. 54 61
18983524 2008
20
Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case. 61 54
18823322 2008
21
Hematological abnormalities in patients with distal renal tubular acidosis and hemoglobinopathies. 54 61
18266205 2008
22
Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology. 54 61
18458110 2008
23
Complement factor H deficiency and posttransplantation glomerulonephritis with isolated C3 deposits. 61 54
18371543 2008
24
Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold. 54 61
18182167 2008
25
Chronic non-spherocytic hemolytic anemia associated with severe neurological disease due to gamma-glutamylcysteine synthetase deficiency in a patient of Moroccan origin. 54 61
18024385 2007
26
Altered expression of PGK1 in a family with phosphoglycerate kinase deficiency. 61 54
17661373 2007
27
Restoration of the balanced alpha/beta-globin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach. 54 61
17716993 2007
28
Point mutations involved in red cell stomatocytosis convert the electroneutral anion exchanger 1 to a nonselective cation conductance. 54 61
17554061 2007
29
Seven different glucose-6-phosphate dehydrogenase variants including a new variant distributed in Lam Dong Province in southern Vietnam. 54 61
17726510 2007
30
Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency. 61 54
17550844 2007
31
In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach. 54 61
17547515 2007
32
Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia. 54 61
17056673 2007
33
Inborn errors in the metabolism of glutathione. 54 61
17397529 2007
34
Thrombotic microangiopathy in a sirolimus-treated renal transplant patient receiving gemcitabine for lung cancer. 61 54
17338432 2007
35
Glucose-6-phosphate dehydrogenase--from oxidative stress to cellular functions and degenerative diseases. 61 54
17623517 2007
36
Improved quantitative method for G6PD deficiency detection. 61 54
17385678 2007
37
Red cell glucose phosphate isomerase (GPI): a molecular study of three novel mutations associated with hereditary nonspherocytic hemolytic anemia. 54 61
17041899 2006
38
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder. 54 61
16956825 2006
39
Monoclonal anti-double-stranded DNA antibodies cross-react with phosphoglycerate kinase 1 and inhibit the expression and production of IL-2 in activated Jurkat T cell line. 61 54
16857429 2006
40
Haptoglobin levels are associated with haptoglobin genotype and alpha+ -Thalassemia in a malaria-endemic area. 54 61
16760505 2006
41
G6PD deficiency with hemolytic anemia due to a rare gene deletion--a report of the first case in Malaysia. 54 61
16753852 2006
42
Reactivity of blood samples spotted onto filter papers in the WST-8 method for screening of G6PD deficiency. 61 54
16680190 2006
43
Rh proteins: key structural and functional components of the red cell membrane. 61 54
15961204 2006
44
Hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency: a biochemical, genetic and clinical overview. 61 54
16522554 2006
45
New insights into paroxysmal nocturnal hemoglobinuria. 54 61
17124035 2006
46
Hemolysis and methemoglobinemia secondary to rasburicase administration. 61 54
16204390 2005
47
Complications related to dapsone use for Pneumocystis jirovecii pneumonia prophylaxis in solid organ transplant recipients. 61 54
16212642 2005
48
An adult with acute poststreptococcal glomerulonephritis complicated by hemolytic uremic syndrome and nephrotic syndrome. 54 61
16183409 2005
49
Life-threatening nonspherocytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression. 54 61
15870173 2005
50
Two new glucose-6-phosphate dehydrogenase mutations causing chronic hemolysis. 54 61
16079115 2005

Variations for Hemolytic Anemia

ClinVar genetic disease variations for Hemolytic Anemia:

6 (show top 50) (show all 141)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 LOC106099062 , HBB , LOC107133510 NM_000518.5(HBB):c.127T>C (p.Phe43Leu) SNV Pathogenic 15251 rs33924146 GRCh37: 11:5247995-5247995
GRCh38: 11:5226765-5226765
2 LOC106099062 , HBB , LOC107133510 NM_000518.4(HBB):c.127T>G (p.Phe43Val) SNV Pathogenic 15347 rs33924146 GRCh37: 11:5247995-5247995
GRCh38: 11:5226765-5226765
3 SPTB NM_001355436.2(SPTB):c.5794_5798+6del Deletion Pathogenic 523359 rs1555367318 GRCh37: 14:65237597-65237607
GRCh38: 14:64770879-64770889
4 PKLR NM_000298.6(PKLR):c.1291G>A (p.Ala431Thr) SNV Likely pathogenic 812888 rs762591322 GRCh37: 1:155263113-155263113
GRCh38: 1:155293322-155293322
5 SPTA1 NM_003126.4(SPTA1):c.6549-12G>A SNV Likely pathogenic 258955 rs857716 GRCh37: 1:158587390-158587390
GRCh38: 1:158617600-158617600
6 SPTA1 NM_003126.4(SPTA1):c.6531-12C>T SNV Likely pathogenic 258954 rs28525570 GRCh37: 1:158587858-158587858
GRCh38: 1:158618068-158618068
7 SPTA1 NM_003126.4(SPTA1):c.5572C>G (p.Leu1858Val) SNV Likely pathogenic 258948 rs3737515 GRCh37: 1:158597507-158597507
GRCh38: 1:158627717-158627717
8 SPTA1 NM_003126.4(SPTA1):c.4177C>T (p.Gln1393Ter) SNV Likely pathogenic 812889 rs1571436535 GRCh37: 1:158614995-158614995
GRCh38: 1:158645205-158645205
9 SPTA1 NM_003126.4(SPTA1):c.2353C>T (p.Arg785Ter) SNV Likely pathogenic 812891 rs2022057 GRCh37: 1:158632603-158632603
GRCh38: 1:158662813-158662813
10 GPI NM_000175.5(GPI):c.572A>G (p.His191Arg) SNV Likely pathogenic 811712 rs758281551 GRCh37: 19:34868725-34868725
GRCh38: 19:34377820-34377820
11 SLC4A1 NM_000342.4(SLC4A1):c.2701C>T (p.Arg901Trp) SNV Uncertain significance 64423 rs201265160 GRCh37: 17:42327861-42327861
GRCh38: 17:44250493-44250493
12 SLC4A1 NM_000342.4(SLC4A1):c.173A>G (p.Tyr58Cys) SNV Uncertain significance 323520 rs368863744 GRCh37: 17:42338179-42338179
GRCh38: 17:44260811-44260811
13 SLC4A1 NM_000342.4(SLC4A1):c.202G>A (p.Glu68Lys) SNV Uncertain significance 323519 rs13306787 GRCh37: 17:42338150-42338150
GRCh38: 17:44260782-44260782
14 SLC4A1 NM_000342.4(SLC4A1):c.*351G>T SNV Uncertain significance 323495 rs138242019 GRCh37: 17:42327475-42327475
GRCh38: 17:44250107-44250107
15 SLC4A1 NM_000342.4(SLC4A1):c.*977G>A SNV Uncertain significance 323489 rs886052993 GRCh37: 17:42326849-42326849
GRCh38: 17:44249481-44249481
16 SLC4A1 NM_000342.4(SLC4A1):c.*1596A>C SNV Uncertain significance 323480 rs886052990 GRCh37: 17:42326230-42326230
GRCh38: 17:44248862-44248862
17 SLC4A1 NM_000342.4(SLC4A1):c.876+14G>A SNV Uncertain significance 323513 rs571092411 GRCh37: 17:42336517-42336517
GRCh38: 17:44259149-44259149
18 SLC4A1 NM_000342.4(SLC4A1):c.*1606_*1608dup Duplication Uncertain significance 323478 rs57466226 GRCh37: 17:42326217-42326218
GRCh38: 17:44248849-44248850
19 SLC4A1 NM_000342.4(SLC4A1):c.*1608dup Duplication Uncertain significance 323477 rs57466226 GRCh37: 17:42326217-42326218
GRCh38: 17:44248849-44248850
20 SLC4A1 NM_000342.4(SLC4A1):c.*872G>C SNV Uncertain significance 323492 rs886052994 GRCh37: 17:42326954-42326954
GRCh38: 17:44249586-44249586
21 SLC4A1 NM_000342.4(SLC4A1):c.2482-9C>T SNV Uncertain significance 323502 rs886052995 GRCh37: 17:42328709-42328709
GRCh38: 17:44251341-44251341
22 SLC4A1 NM_000342.4(SLC4A1):c.*1273G>T SNV Uncertain significance 323484 rs769140134 GRCh37: 17:42326553-42326553
GRCh38: 17:44249185-44249185
23 SLC4A1 NM_000342.4(SLC4A1):c.2630T>C (p.Ile877Thr) SNV Uncertain significance 323501 rs765911147 GRCh37: 17:42328552-42328552
GRCh38: 17:44251184-44251184
24 SLC4A1 NM_000342.4(SLC4A1):c.*1316C>T SNV Uncertain significance 323482 rs886052991 GRCh37: 17:42326510-42326510
GRCh38: 17:44249142-44249142
25 SLC4A1 NM_000342.4(SLC4A1):c.1637A>G (p.Asp546Gly) SNV Uncertain significance 323507 rs886052998 GRCh37: 17:42333204-42333204
GRCh38: 17:44255836-44255836
26 SLC4A1 NM_000342.4(SLC4A1):c.1225G>A (p.Val409Ile) SNV Uncertain significance 323511 rs201821517 GRCh37: 17:42335411-42335411
GRCh38: 17:44258043-44258043
27 SLC4A1 NM_000342.4(SLC4A1):c.*1198A>T SNV Uncertain significance 323487 rs886052992 GRCh37: 17:42326628-42326628
GRCh38: 17:44249260-44249260
28 SLC4A1 NM_000342.4(SLC4A1):c.-65C>A SNV Uncertain significance 323523 rs886053001 GRCh37: 17:42340299-42340299
GRCh38: 17:44262931-44262931
29 SLC4A1 NM_000342.4(SLC4A1):c.*1676A>G SNV Uncertain significance 323476 rs745898810 GRCh37: 17:42326150-42326150
GRCh38: 17:44248782-44248782
30 SLC4A1 NM_000342.4(SLC4A1):c.2208C>T (p.Asn736=) SNV Uncertain significance 323505 rs766674440 GRCh37: 17:42330589-42330589
GRCh38: 17:44253221-44253221
31 SLC4A1 NM_000342.4(SLC4A1):c.636A>G (p.Ser212=) SNV Uncertain significance 323515 rs886053000 GRCh37: 17:42336923-42336923
GRCh38: 17:44259555-44259555
32 SLC4A1 NM_000342.4(SLC4A1):c.2210C>T (p.Ala737Val) SNV Uncertain significance 323504 rs886052997 GRCh37: 17:42330587-42330587
GRCh38: 17:44253219-44253219
33 SLC4A1 NM_000342.4(SLC4A1):c.697C>G (p.Arg233Gly) SNV Uncertain significance 323514 rs779054292 GRCh37: 17:42336710-42336710
GRCh38: 17:44259342-44259342
34 SLC4A1 NM_000342.4(SLC4A1):c.*1832G>A SNV Uncertain significance 323474 rs886052988 GRCh37: 17:42325994-42325994
GRCh38: 17:44248626-44248626
35 SLC4A1 NM_000342.4(SLC4A1):c.*1273del Deletion Uncertain significance 323483 rs768606768 GRCh37: 17:42326553-42326553
GRCh38: 17:44249185-44249185
36 SLC4A1 NM_000342.4(SLC4A1):c.*1608del Deletion Uncertain significance 323479 rs57466226 GRCh37: 17:42326218-42326218
GRCh38: 17:44248850-44248850
37 SLC4A1 NM_000342.4(SLC4A1):c.2243G>A (p.Gly748Glu) SNV Uncertain significance 323503 rs886052996 GRCh37: 17:42330554-42330554
GRCh38: 17:44253186-44253186
38 SLC4A1 NM_000342.4(SLC4A1):c.1431+15G>T SNV Uncertain significance 323508 rs886052999 GRCh37: 17:42335012-42335012
GRCh38: 17:44257644-44257644
39 SLC4A1 NM_000342.4(SLC4A1):c.1431+13T>G SNV Uncertain significance 323509 rs747632229 GRCh37: 17:42335014-42335014
GRCh38: 17:44257646-44257646
40 G6PD NM_001360016.2(G6PD):c.1096A>G (p.Lys366Glu) SNV Uncertain significance 374205 rs1057518975 GRCh37: X:153760973-153760973
GRCh38: X:154532758-154532758
41 SLC4A1 NM_000342.4(SLC4A1):c.*1693G>A SNV Uncertain significance 889077 GRCh37: 17:42326133-42326133
GRCh38: 17:44248765-44248765
42 SLC4A1 NM_000342.4(SLC4A1):c.*753C>T SNV Uncertain significance 889211 GRCh37: 17:42327073-42327073
GRCh38: 17:44249705-44249705
43 SLC4A1 NM_000342.4(SLC4A1):c.2401A>C (p.Ser801Arg) SNV Uncertain significance 889392 GRCh37: 17:42328867-42328867
GRCh38: 17:44251499-44251499
44 SLC4A1 NM_000342.4(SLC4A1):c.1928C>T (p.Ser643Phe) SNV Uncertain significance 889445 GRCh37: 17:42331993-42331993
GRCh38: 17:44254625-44254625
45 SLC4A1 NM_000342.4(SLC4A1):c.1202T>G (p.Phe401Cys) SNV Uncertain significance 889517 GRCh37: 17:42335434-42335434
GRCh38: 17:44258066-44258066
46 SLC4A1 NM_000342.4(SLC4A1):c.719C>T (p.Pro240Leu) SNV Uncertain significance 889578 GRCh37: 17:42336688-42336688
GRCh38: 17:44259320-44259320
47 SLC4A1 NM_000342.4(SLC4A1):c.706T>G (p.Phe236Val) SNV Uncertain significance 889579 GRCh37: 17:42336701-42336701
GRCh38: 17:44259333-44259333
48 SLC4A1 NM_000342.4(SLC4A1):c.697C>T (p.Arg233Cys) SNV Uncertain significance 889580 GRCh37: 17:42336710-42336710
GRCh38: 17:44259342-44259342
49 SLC4A1 NM_000342.4(SLC4A1):c.*1609C>T SNV Uncertain significance 889776 GRCh37: 17:42326217-42326217
GRCh38: 17:44248849-44248849
50 SLC4A1 NM_000342.4(SLC4A1):c.*1047T>C SNV Uncertain significance 889828 GRCh37: 17:42326779-42326779
GRCh38: 17:44249411-44249411

Expression for Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for Hemolytic Anemia

Pathways related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 SLC4A1 RHAG PKLR PGK1 NT5C3A HK1
2
Show member pathways
12.63 PKLR PGK1 HK1 GPI G6PD ALDOA
3
Show member pathways
12.49 PKLR PGK1 HK1 GPI ALDOA
4 12.31 HK1 HBB G6PD ALDOA
5
Show member pathways
11.96 PKLR GSS GCLC AK1
6
Show member pathways
11.76 PKLR PGK1 HK1 GPI G6PD ALDOA
7 11.75 PGK1 HK1 ALDOA
8
Show member pathways
11.57 PKLR PGK1 HK1 ALDOA
9
Show member pathways
11.48 GPI G6PD ALDOA
10 11.47 PGK1 HK1 ALDOA
11
Show member pathways
11.09 SLC4A1 RHAG HBB
12
Show member pathways
10.66 PKLR PGK1
13 10.13 PGK1 HK1 GPI G6PD
14 10.11 HK1 GPI G6PD

GO Terms for Hemolytic Anemia

Cellular components related to Hemolytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.13 SPTB SPTA1 PKLR PGK1 NT5C3A HK1
2 extracellular exosome GO:0070062 9.65 SLC4A1 PKLR PGK1 HBB GSS GPI
3 ficolin-1-rich granule lumen GO:1904813 9.61 HBB GPI ALDOA
4 cytoplasmic side of plasma membrane GO:0009898 9.43 SPTA1 SLC4A1 G6PD
5 spectrin GO:0008091 9.4 SPTB SPTA1
6 spectrin-associated cytoskeleton GO:0014731 9.37 SPTB SPTA1
7 intrinsic component of the cytoplasmic side of the plasma membrane GO:0031235 9.16 SPTB SPTA1
8 cortical cytoskeleton GO:0030863 8.8 SPTA1 SLC4A1 EPB42

Biological processes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.76 PKLR HK1 GPI G6PD
2 blood coagulation GO:0007596 9.73 SLC4A1 HBB CD59 ADAMTS13
3 actin filament capping GO:0051693 9.54 SPTB SPTA1
4 gluconeogenesis GO:0006094 9.54 PGK1 GPI ALDOA
5 ion homeostasis GO:0050801 9.52 SLC4A1 EPB42
6 glutathione biosynthetic process GO:0006750 9.51 GSS GCLC
7 bicarbonate transport GO:0015701 9.5 SLC4A1 RHAG HBB
8 erythrocyte maturation GO:0043249 9.49 G6PD EPB42
9 response to xenobiotic stimulus GO:0009410 9.48 GSS GCLC
10 response to cadmium ion GO:0046686 9.43 GSS GPI GCLC
11 cellular ion homeostasis GO:0006873 9.4 SLC4A1 RHAG
12 glycolytic process GO:0006096 9.35 PKLR PGK1 HK1 GPI ALDOA
13 glucose 6-phosphate metabolic process GO:0051156 9.33 HK1 GPI G6PD
14 canonical glycolysis GO:0061621 9.02 PKLR PGK1 HK1 GPI ALDOA

Molecular functions related to Hemolytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.91 PKLR PGK1 HK1 GSS GCLC EPB42
2 structural constituent of cytoskeleton GO:0005200 9.5 SPTB SPTA1 EPB42
3 magnesium ion binding GO:0000287 9.46 PKLR NT5C3A GSS GCLC
4 glucose binding GO:0005536 9.26 HK1 G6PD
5 hemoglobin binding GO:0030492 8.96 SLC4A1 HBB
6 ankyrin binding GO:0030506 8.8 SPTB SLC4A1 RHAG

Sources for Hemolytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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