MCID: HML002
MIFTS: 64

Hemolytic Anemia

Categories: Blood diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Hemolytic Anemia

MalaCards integrated aliases for Hemolytic Anemia:

Name: Hemolytic Anemia 39 12 30 6 15 64 17
Anemia, Hemolytic 45 41 74
Anemia Hemolytic 12 56

Classifications:



External Ids:

Disease Ontology 12 DOID:583
MeSH 45 D000743
NCIt 51 C34376
SNOMED-CT 69 61261009
ICD10 34 D55-D59
UMLS 74 C0002878

Summaries for Hemolytic Anemia

PubMed Health : 64 About hemolytic anemia: Hemolytic anemia (HEE-moh-lit-ick uh-NEE-me-uh) is a condition in which red blood cells are destroyed and removed from the bloodstream before their normal lifespan is over.Red blood cells are disc-shaped and look like doughnuts without holes in the center. These cells carry oxygen to your body. They also remove carbon dioxide (a waste product) from your body.Red blood cells are made in the bone marrow—a sponge-like tissue inside the bones. They live for about 120 days in the bloodstream and then die.White blood cells and platelets (PLATE-lets) also are made in the bone marrow. White blood cells help fight infections. Platelets stick together to seal small cuts or breaks on blood vessel walls and stop bleeding.When blood cells die, the body's bone marrow makes more blood cells to replace them. However, in hemolytic anemia, the bone marrow can't make red blood cells fast enough to meet the body's needs.Hemolytic anemia can lead to many health problems, such as fatigue (tiredness), pain, irregular heartbeats called arrhythmias (ah-RITH-me-ahs), an enlarged heart, and heart failure.

MalaCards based summary : Hemolytic Anemia, also known as anemia, hemolytic, is related to congenital nonspherocytic hemolytic anemia and pyruvate kinase deficiency of red cells, and has symptoms including icterus An important gene associated with Hemolytic Anemia is SPTB (Spectrin Beta, Erythrocytic), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Iron and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are no effect and Increased simian virus 40 (SV40) infection

Wikipedia : 77 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

Related Diseases for Hemolytic Anemia

Diseases in the Hemolytic Anemia family:

Anemia, Autoimmune Hemolytic Congenital Hemolytic Anemia
Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 627)
# Related Disease Score Top Affiliating Genes
1 congenital nonspherocytic hemolytic anemia 34.2 G6PD GPI NT5C3A PKLR
2 pyruvate kinase deficiency of red cells 34.0 G6PD PKLR
3 congenital hemolytic anemia 33.9 ANK1 G6PD GPI HBB PKLR SPTA1
4 hereditary spherocytosis 33.1 ANK1 EPB42 G6PD HBB PKLR SLC4A1
5 glucosephosphate dehydrogenase deficiency 33.0 G6PD HBB
6 pyropoikilocytosis, hereditary 33.0 SPTA1 SPTB
7 glucosephosphate isomerase deficiency 32.8 G6PD GPI
8 spherocytosis, type 3 32.6 HBB SPTA1
9 glutathione synthetase deficiency 32.6 G6PD GSS
10 beta-thalassemia 30.5 G6PD HBB SPTB
11 hereditary elliptocytosis 30.5 ANK1 SLC4A1 SPTA1 SPTB
12 malaria 30.4 ADAMTS13 G6PD HBB PKLR SLC4A1
13 kernicterus 30.0 G6PD SLC4A1
14 hemolytic anemia, nonspherocytic, due to hexokinase deficiency 12.7
15 uridine 5-prime monophosphate hydrolase deficiency, hemolytic anemia due to 12.7
16 gamma-glutamylcysteine synthetase deficiency, hemolytic anemia due to 12.7
17 adenylate kinase deficiency, hemolytic anemia due to 12.7
18 warm antibody hemolytic anemia 12.6
19 hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 12.6
20 renal tubular acidosis, distal, with hemolytic anemia 12.6
21 drug-induced autoimmune hemolytic anemia 12.5
22 glutathione synthetase deficiency of erythrocytes, hemolytic anemia due to 12.5
23 hemolytic anemia, congenital, x-linked 12.5
24 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 12.5
25 anemia, autoimmune hemolytic 12.5
26 mixed-type autoimmune hemolytic anemia 12.3
27 systemic lupus erythematosus with hemolytic anemia 1 12.3
28 autoimmune hemolytic anemia, warm type 12.3
29 thrombotic thrombocytopenic purpura, congenital 12.3
30 hemolytic anemia, lethal congenital nonspherocytic, with genital and other abnormalities 12.3
31 adenosine deaminase, elevated, hemolytic anemia due to 12.2
32 hemolytic anemia with thermal sensitivity of red cells 12.2
33 glut1 deficiency syndrome 2 12.2
34 triosephosphate isomerase deficiency 12.2
35 lymphopenic hypergammaglobulinemia, antibody deficiency, autoimmune hemolytic anemia, and glomerulonephritis 12.1
36 neonatal autoimmune hemolytic anemia 12.1
37 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 12.1
38 hemolytic anemia due to glutathione reductase deficiency 12.1
39 hemolytic anemia due to erythrocyte adenosine deaminase overproduction 12.1
40 anemia, nonspherocytic hemolytic, due to g6pd deficiency 12.1
41 paroxysmal cold hemoglobinuria 12.1
42 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.0
43 evans' syndrome 12.0
44 glucose phosphate isomerase deficiency 12.0
45 glutathione peroxidase deficiency 12.0
46 cold agglutinin disease 12.0
47 hemolytic-uremic syndrome 11.9
48 rh-null, regulator type 11.9
49 phosphoglycerate kinase deficiency 11.8
50 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.8

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to Hemolytic Anemia

Symptoms & Phenotypes for Hemolytic Anemia

UMLS symptoms related to Hemolytic Anemia:


icterus

GenomeRNAi Phenotypes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ADAMTS13 AK1 ALDOA ANK1 CD59 EPB42
2 Increased simian virus 40 (SV40) infection GR00356-A-2 9.13 HK1 PGK1 PKLR

MGI Mouse Phenotypes related to Hemolytic Anemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ADAMTS13 ANK1 CD59 EPB42 G6PD GPI
2 homeostasis/metabolism MP:0005376 9.8 ADAMTS13 AK1 ANK1 CD59 EPB42 G6PD
3 mortality/aging MP:0010768 9.4 ADAMTS13 ANK1 CD59 G6PD GCLC GPI

Drugs & Therapeutics for Hemolytic Anemia

PubMedHealth treatment related to Hemolytic Anemia: 64

Treatments for hemolytic anemia include blood transfusions, medicines, plasmapheresis (PLAZ-meh-feh-RE-sis), surgery, blood and marrow stem cell transplants, and lifestyle changes.People who have mild hemolytic anemia may not need treatment, as long as the condition doesn't worsen. People who have severe hemolytic anemia usually need ongoing treatment. Severe hemolytic anemia can be fatal if it's not properly treated.

Drugs for Hemolytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 525)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7439-89-6, 15438-31-0 27284 23925
2
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1 73590-58-6 4594
3
Hydroxyurea Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 127-07-1 3657
4
Deferiprone Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 30652-11-0 2972
5
Deferoxamine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 70-51-9 2973
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
7
Basiliximab Approved, Investigational Phase 4,Phase 2 179045-86-4, 152923-56-3
8
Mycophenolic acid Approved Phase 4,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
9
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
10
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
11
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Phase 1 10102-43-9 145068
12
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
13
Deferasirox Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 201530-41-8 5493381
14
Zoledronic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
15
Acetaminophen Approved Phase 4,Phase 2,Phase 1,Not Applicable 103-90-2 1983
16
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
17
Proguanil Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 500-92-5 4923
18
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1406-66-2 14986
19
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 53123-88-9 46835353 5284616 6436030
20
Everolimus Approved Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 159351-69-6 70789204 6442177
21
chloroquine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54-05-7 2719
22
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 6740-88-1 3821
23
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 93-14-1 3516
24
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2 198153-51-4 5360545
25
Ribavirin Approved Phase 4,Phase 3,Phase 2,Not Applicable 36791-04-5 37542
26
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
27
Prilocaine Approved Phase 4 721-50-6 4906
28
Mannitol Approved, Investigational Phase 4,Phase 3 69-65-8 6251 453
29
Racepinephrine Approved Phase 4 329-65-7 838
30
Sodium Citrate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 68-04-2
31
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
32
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 32051
33
Zinc sulfate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7733-02-0
34
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 466-99-9 5284570
35
Primaquine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90-34-6 4908
36
Sofosbuvir Approved Phase 4,Phase 2 1190307-88-0 45375808
37
Velpatasvir Approved, Investigational Phase 4 1377049-84-7 67683363
38
Ledipasvir Approved Phase 4,Phase 2 1256388-51-8 67505836
39
Dapsone Approved, Investigational Phase 4,Phase 3 80-08-0 2955
40
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
41
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 1 104987-11-3 6473866 445643 439492
42
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
43
Amodiaquine Approved, Investigational Phase 4,Phase 1,Phase 2 86-42-0 2165
44
Sulfadoxine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 2447-57-6 17134
45
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 58-14-0 4993
46
Warfarin Approved Phase 4,Phase 2,Phase 1,Not Applicable 81-81-2 54678486 6691
47
tannic acid Approved Phase 4,Phase 2,Phase 1,Not Applicable 1401-55-4
48
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
49
Codeine Approved, Illicit Phase 4,Phase 1,Phase 2 76-57-3 5284371
50
Metformin Approved Phase 4,Early Phase 1 657-24-9 14219 4091

Interventional clinical trials:

(show top 50) (show all 1103)
# Name Status NCT ID Phase Drugs
1 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
2 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
3 Mobile-Directly Observed Therapy on Adherence to Hydroxyurea Unknown status NCT02844673 Phase 4 Hydroxyurea
4 B Memory Cell Response to Vaccination With the 13-valent Pneumococcal Conjugate Vaccine in Asplenic Individuals Unknown status NCT01846923 Phase 4
5 The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study Unknown status NCT01323608 Phase 4 Vitamin D3;Placebo
6 Combined Chelation Treatment With Deferiprone and Deferoxamine in Thalassemia Major Unknown status NCT00103753 Phase 4 deferiprone
7 Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major Unknown status NCT02342145 Phase 4 Basiliximab,;cyclosporine A;Methotrexate;Mycophenolate mofetil
8 Retreatment of Dialysis Patients With Chronic Hepatitis C With Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin Completed NCT00491179 Phase 4 Pegylated interferon alfa-2a and ribavirin;Pegylated interferon alfa-2a and ribavirin
9 Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin for Treatment-Naïve Hemodialysis Patients With Chronic Hepatitis C Completed NCT00491244 Phase 4 Peginterferon alfa-2a and ribavirin;Peginterferon alfa-2a
10 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Genotype 1 and Human Immunodeficiency Virus-1 (HIV-1) Co-infection Completed NCT00353418 Phase 4 Peginterferon alfa-2a;Ribavirin;Ribavirin
11 Evaluation of Ureteral Patency in the Post-indigo Carmine Era Completed NCT02677623 Phase 4 Pyridium;Sodium Fluorescein;Mannitol
12 Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3 Completed NCT00056862 Phase 4 Peginterferon alfa-2a;Peginterferon alfa-2a;Ribavirin
13 Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C With and Without Kidney Disease Completed NCT00028093 Phase 4 Peginterferon alfa-2a with Ribavirin;Peginterferon alfa-2a
14 Long-Term Therapy With Ribavirin for Chronic Hepatitis C Completed NCT00001854 Phase 4 Ribavirin
15 Intranasal Fentanyl Versus Intravenous Morphine in the Treatment of Severe Painful Sickle Cell Crises in Children Completed NCT03682211 Phase 4 Fentanyl Citrate;Morphine sulphate
16 Zinc Supplementation on Cellular Immunity in Thalassemia Major Completed NCT03117192 Phase 4 Zinc Sulfate;Sucrose Syrup
17 Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions Completed NCT02731157 Phase 4 Rejuvesol
18 Efficacy and Safety Study of Deferasirox in Patients With Non-transfusion Dependent Thalassemia Completed NCT01709838 Phase 4 ICL670 deferasirox
19 Future of Spermatogenesis in Men With Sickle Cell Disease Medically Treated Completed NCT01609192 Phase 4 Hydrea® (hydroxyurea )
20 Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis Completed NCT01482091 Phase 4 Fentanyl Citrate;Normal Saline
21 Efficacy Study of the Use of Sequential DFP-DFO Versus DFP Completed NCT00733811 Phase 4 Deferiprone (DFP) and Deferoxamine (DFO);Deferiprone (DFP)
22 Evaluation of Efficacy of Zoledronic Acid in Patients With Haemoglobin Syndromes (Thalassemia and Sicle Cell Anaemia) and Risk of Skeletal Events Completed NCT00346242 Phase 4 Zoledronic Acid
23 Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in Indonesia Completed NCT03095326 Phase 4 Sucrose
24 Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH) Completed NCT02522104 Phase 4 Siklos
25 Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease Completed NCT02222246 Phase 4 Hydromorphone (Standardized, weight-based dosing);Morphine Sulfate (Standardized, weight-based dosing);Hydromorphone (Patient Specific dosing);Morphine Sulfate (Patient Specific dosing)
26 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
27 Post Hematopoietic Stem Cell Transplantation Completed NCT01610297 Phase 4 ICL670
28 Combo Chelation Trial Completed NCT00901199 Phase 4 Combo Chelation with Deferasirox (Exjade) and Desferal (DFO)
29 Pilot Study for Patients With Poor Response to Deferasirox Completed NCT00749515 Phase 4 Deferoxamine;Deferasirox
30 Safety and Tolerability of Low Dose Primaquine Completed NCT02434952 Phase 4 Dihydroartemisinin piperaquine (DHA PP);Primaquine
31 Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration) Completed NCT00171301 Phase 4 Deferasirox
32 Efficacy Study in Removing Excess Iron From the Heart Completed NCT00105495 Phase 4 Ferriprox (deferiprone);Desferal (deferoxamine)
33 Hyalornic Acid Level in β-Thalassemic Children Treated for Hepatitis C Virus Completed NCT03961828 Phase 4 Ledipasvir 90 MG / Sofosbuvir 400 MG [Harvoni]
34 Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major Completed NCT00800761 Phase 4 Deferoxamine and Deferiprone;Deferoxamine
35 Sofosbuvir/Ledipasvir for Hepatitis C Genotype 1-6 in Patients With Transfusion-Dependent Thalassemia: An Open Label Trial Completed NCT03032666 Phase 4 sofosbuvir/velpatasvir
36 This Study Will Evaluate Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndromes (MDS), Thalassemia and Rare Anemia Types Having Transfusion-induced Iron Overload. Completed NCT01250951 Phase 4 Deferasirox
37 Phase IV Study to Gather More Information About the Safety of ACZONE Gel, 5% in Treating Subjects With Acne Who Have G6PD Deficiency Completed NCT00243542 Phase 4 ACZONE Gel, 5%;Vehicle
38 Pegasys® Plus Ribavirin in Thalassemic Patients With Hepatitis C Virus Infection Completed NCT00707850 Phase 4 PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)
39 Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron Overload Completed NCT00564941 Phase 4 deferasirox
40 Eculizumab Pharmacokinetics/Pharmacodynamics Study in Pediatric/Adolescent Paroxysmal Nocturnal Hemoglobinuria (PNH) Completed NCT00867932 Phase 4 Eculizumab
41 The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Major Recruiting NCT02984475 Phase 4 Metformin
42 Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency) Recruiting NCT03374111 Phase 4 Colla corii asini;a Simulate Agent of Colla corii asini granule
43 Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises? Recruiting NCT03541980 Phase 4 Acetaminophen;Normal saline
44 Study on the Mechanism of Colla Corri Asini in the Treatment of Thalassemia Patients With Pregnancy Anemia Recruiting NCT03392298 Phase 4 Colla corii asini
45 Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major Recruiting NCT03171831 Phase 4 Busulfan;Cyclophosphamide;Fludarabine;Mycophenolate mofetil;Tacrolimus;Methotrexate;Thymoglobulin;Basiliximab
46 Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children Recruiting NCT03591575 Phase 4 Deferiprone oral solution;Placebo
47 Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias Recruiting NCT02041299 Phase 4 Deferiprone;Deferoxamine
48 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Recruiting NCT03178643 Phase 4 Proguanil Oral Tablet;Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ);Dihydroartemisinin-Piperaquine (DP)
49 L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension Recruiting NCT03402191 Phase 4 L-arginine;Sildenafil
50 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive

Search NIH Clinical Center for Hemolytic Anemia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: anemia, hemolytic

Genetic Tests for Hemolytic Anemia

Genetic tests related to Hemolytic Anemia:

# Genetic test Affiliating Genes
1 Hemolytic Anemia 30

Anatomical Context for Hemolytic Anemia

MalaCards organs/tissues related to Hemolytic Anemia:

42
Bone, Bone Marrow, T Cells, Liver, Heart, Kidney, Testes

Publications for Hemolytic Anemia

Articles related to Hemolytic Anemia:

(show top 50) (show all 3346)
# Title Authors Year
1
Etoricoxib-induced immune hemolytic anemia: first case presenting acute kidney failure. ( 30865300 )
2019
2
Severe hemolytic anemia due to combined α thalassemia and de novo Hemoglobin Sabine. ( 30673812 )
2019
3
Hot and Cold: A Concurrent Warm and Cold Autoimmune Hemolytic Anemia in B-cell Prolymphocytic Leukemia. ( 30947164 )
2019
4
Hemolytic Anemia of Malignancy: A Case Study Involving Signet Ring Cell Metastatic Breast Cancer with Severe Microangiopathic Hemolytic Anemia. ( 31043946 )
2019
5
High efficacy of eculizumab treatment for fulminant hemolytic anemia in primary cold agglutinin disease. ( 30324459 )
2019
6
Severe congenital hemolytic anemia caused by a novel compound heterozygous PKLR gene mutation in a Chinese boy. ( 30628965 )
2019
7
Aberrant splicing contributes to severe α-spectrin-linked congenital hemolytic anemia. ( 31038472 )
2019
8
Refractory immune hemolytic anemia in an immunocompetent infant with cytomegalovirus infection. ( 31045313 )
2019
9
Glucose Phosphate Isomerase Deficiency: High Prevalence of p.Arg347His Mutation in Indian Population Associated with Severe Hereditary Non-Spherocytic Hemolytic Anemia Coupled with Neurological Dysfunction. ( 31030358 )
2019
10
Abdominal pain in combination with an unexplained hemolytic anemia are crucial signs to test for paroxysmal nocturnal hemoglobinuria: A case report. ( 30656036 )
2019
11
Severe hemolytic anemia due to transient acquired G6PD deficiency after ingestion of sodium chlorite. ( 30231641 )
2019
12
A new onset of thrombocytopenia and microangiopathic hemolytic anemia in the healthcare setting: A challenge for diagnosis. ( 30264862 )
2019
13
Pertussis: An uncommon cause of microangiopathic hemolytic anemia in an infant. ( 30328133 )
2019
14
Autoimmune hemolytic anemia associated with the use of immune checkpoint inhibitors for cancer: 68 cases from the Food and Drug Administration database and review. ( 30347480 )
2019
15
Delayed Hemolytic Anemia after Treatment with Artesunate: Case Report and Literature Review. ( 30411691 )
2019
16
Presumptive Glucocorticoid-Induced Refractory Hypocalcemia in a Dog with Idiopathic Immune-Mediated Hypoparathyroidism, Thrombocytopenia, and Hemolytic Anemia. ( 30427709 )
2019
17
Vaccination and Associated Adverse Events in Dogs Previously Treated for Primary Immune-Mediated Hemolytic Anemia. ( 30427712 )
2019
18
Prognosis of autoimmune hemolytic anemia in critically ill patients. ( 30536106 )
2019
19
Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: A critical review of the literature. ( 30537439 )
2019
20
IgM-mediated Warm Autoimmune Hemolytic Anemia: An Autopsy Report. ( 30568122 )
2019
21
An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling. ( 30605837 )
2019
22
Ceftriaxone-induced immune hemolytic anemia in a case with large vestibular aqueduct syndrome after cochlear implant. ( 30628967 )
2019
23
Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker. ( 30658594 )
2019
24
The Case | A 78-year-old woman with acute kidney injury and hemolytic anemia. ( 30665579 )
2019
25
Low-dose rituximab in autoimmune hemolytic anemia: 10 years after. ( 30670440 )
2019
26
The first reported case of drug-induced hemolytic anemia caused by dimethyl fumarate in a patient with multiple sclerosis. ( 30702749 )
2019
27
A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura. ( 30733882 )
2019
28
Immunosensor for the Diagnostics of Autoimmune Hemolytic Anemia (AIHA) Based on Immobilization of a Monoclonal Antibody on a Layer of Silk Fibroin. ( 30764933 )
2019
29
Clinical and Laboratory Features of Autoimmune Hemolytic Anemia Associated with Immune Checkpoint Inhibitors. ( 30790338 )
2019
30
Efficacy of L-carnitine on ribavirin-induced hemolytic anemia in patients with hepatitis C virus infection. ( 30798587 )
2019
31
ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. ( 30806491 )
2019
32
Transient appearance of ring sideroblasts in peripheral blood in the acute phase of secondary hemolytic anemia. ( 30819781 )
2019
33
Pembrolizumab-induced Autoimmune Hemolytic Anemia and Hemophagocytic Lymphohistiocytosis in Non-small Cell Lung Cancer. ( 30828042 )
2019
34
Autoimmune Hemolytic Anemia, Erythrophagocytosis and Liver Dysfunction After Cefixime Use for Urinary Tract Infection in a Child. ( 30828180 )
2019
35
Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1). ( 30838143 )
2019
36
ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs. ( 30847984 )
2019
37
Infantile Pyknocytosis: An Uncommon Cause of Newborn Hemolytic Anemia. ( 30933020 )
2019
38
Autoimmune hemolytic anemia and ovarian dermoid cysts in pregnancy. ( 30957135 )
2019
39
The Case | Microangiopathic hemolytic anemia in a young female. ( 31010484 )
2019
40
Cardiac Prostheses-Related Hemolytic Anemia. ( 31039274 )
2019
41
Molecular diagnostic update in hereditary hemolytic anemia and neonatal hyperbilirubinemia. ( 31069991 )
2019
42
B-cell depletion induces prolonged remission in patients with giant cell hepatitis and autoimmune hemolytic anemia. ( 31076361 )
2019
43
A case series of pediatric patients with direct antiglobulin test negative autoimmune hemolytic anemia. ( 31111963 )
2019
44
Durable responses in refractory autoimmune hemolytic anemia with alemtuzumab. ( 29334337 )
2019
45
Molecular detection of Mycoplasma ovis in an outbreak of hemolytic anemia in sheep from Veracruz, Mexico. ( 29934796 )
2019
46
Ectopic expression of band 3 anion transport protein in colorectal cancer revealed in an autoimmune hemolytic anemia patient. ( 30063906 )
2019
47
Protective Role of Selenium Against Hemolytic Anemia Is Mediated Through Redox Modulation. ( 30151563 )
2019
48
Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly. ( 30527923 )
2018
49
Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature. ( 29269682 )
2018
50
Acute Brucellosis Presenting as an Autoimmune Hemolytic Anemia. ( 30498608 )
2018

Variations for Hemolytic Anemia

ClinVar genetic disease variations for Hemolytic Anemia:

6 (show top 50) (show all 140)
# Gene Variation Type Significance SNP ID Assembly Location
1 HBB NM_000518.5(HBB): c.127T> C (p.Phe43Leu) single nucleotide variant Pathogenic rs33924146 GRCh38 Chromosome 11, 5226765: 5226765
2 HBB NM_000518.5(HBB): c.127T> C (p.Phe43Leu) single nucleotide variant Pathogenic rs33924146 GRCh37 Chromosome 11, 5247995: 5247995
3 HBB NM_000518.4(HBB): c.127T> G (p.Phe43Val) single nucleotide variant Pathogenic rs33924146 GRCh37 Chromosome 11, 5247995: 5247995
4 HBB NM_000518.4(HBB): c.127T> G (p.Phe43Val) single nucleotide variant Pathogenic rs33924146 GRCh38 Chromosome 11, 5226765: 5226765
5 SLC4A1 NM_000342.3(SLC4A1): c.166A> G (p.Lys56Glu) single nucleotide variant Conflicting interpretations of pathogenicity rs5036 GRCh37 Chromosome 17, 42338945: 42338945
6 SLC4A1 NM_000342.3(SLC4A1): c.166A> G (p.Lys56Glu) single nucleotide variant Conflicting interpretations of pathogenicity rs5036 GRCh38 Chromosome 17, 44261577: 44261577
7 SLC4A1 NM_000342.3(SLC4A1): c.118G> A (p.Glu40Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs45562031 GRCh37 Chromosome 17, 42338993: 42338993
8 SLC4A1 NM_000342.3(SLC4A1): c.118G> A (p.Glu40Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs45562031 GRCh38 Chromosome 17, 44261625: 44261625
9 SLC4A1 NM_000342.3(SLC4A1): c.2561C> T (p.Pro854Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs2285644 GRCh37 Chromosome 17, 42328621: 42328621
10 SLC4A1 NM_000342.3(SLC4A1): c.2561C> T (p.Pro854Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs2285644 GRCh38 Chromosome 17, 44251253: 44251253
11 SLC4A1 NM_000342.3(SLC4A1): c.2701C> T (p.Arg901Trp) single nucleotide variant Uncertain significance rs201265160 GRCh37 Chromosome 17, 42327861: 42327861
12 SLC4A1 NM_000342.3(SLC4A1): c.2701C> T (p.Arg901Trp) single nucleotide variant Uncertain significance rs201265160 GRCh38 Chromosome 17, 44250493: 44250493
13 SLC4A1 NM_000342.3(SLC4A1): c.2712C> T (p.Tyr904=) single nucleotide variant Benign/Likely benign rs45519733 GRCh37 Chromosome 17, 42327850: 42327850
14 SLC4A1 NM_000342.3(SLC4A1): c.2712C> T (p.Tyr904=) single nucleotide variant Benign/Likely benign rs45519733 GRCh38 Chromosome 17, 44250482: 44250482
15 SLC4A1 NM_000342.3(SLC4A1): c.2688T> C (p.Asp896=) single nucleotide variant Benign/Likely benign rs45497993 GRCh37 Chromosome 17, 42327874: 42327874
16 SLC4A1 NM_000342.3(SLC4A1): c.2688T> C (p.Asp896=) single nucleotide variant Benign/Likely benign rs45497993 GRCh38 Chromosome 17, 44250506: 44250506
17 SLC4A1 NM_000342.3(SLC4A1): c.2584G> A (p.Val862Ile) single nucleotide variant Benign/Likely benign rs5026 GRCh37 Chromosome 17, 42328598: 42328598
18 SLC4A1 NM_000342.3(SLC4A1): c.2584G> A (p.Val862Ile) single nucleotide variant Benign/Likely benign rs5026 GRCh38 Chromosome 17, 44251230: 44251230
19 SLC4A1 NM_000342.3(SLC4A1): c.1953C> T (p.His651=) single nucleotide variant Benign/Likely benign rs5021 GRCh37 Chromosome 17, 42331968: 42331968
20 SLC4A1 NM_000342.3(SLC4A1): c.1953C> T (p.His651=) single nucleotide variant Benign/Likely benign rs5021 GRCh38 Chromosome 17, 44254600: 44254600
21 SLC4A1 NM_000342.3(SLC4A1): c.1770G> A (p.Lys590=) single nucleotide variant Benign/Likely benign rs35807245 GRCh38 Chromosome 17, 44255703: 44255703
22 SLC4A1 NM_000342.3(SLC4A1): c.1770G> A (p.Lys590=) single nucleotide variant Benign/Likely benign rs35807245 GRCh37 Chromosome 17, 42333071: 42333071
23 SLC4A1 NM_000342.3(SLC4A1): c.1323G> A (p.Leu441=) single nucleotide variant Benign/Likely benign rs5017 GRCh37 Chromosome 17, 42335135: 42335135
24 SLC4A1 NM_000342.3(SLC4A1): c.1323G> A (p.Leu441=) single nucleotide variant Benign/Likely benign rs5017 GRCh38 Chromosome 17, 44257767: 44257767
25 SLC4A1 NM_000342.3(SLC4A1): c.1249C> T (p.Leu417=) single nucleotide variant Benign/Likely benign rs5015 GRCh37 Chromosome 17, 42335387: 42335387
26 SLC4A1 NM_000342.3(SLC4A1): c.1249C> T (p.Leu417=) single nucleotide variant Benign/Likely benign rs5015 GRCh38 Chromosome 17, 44258019: 44258019
27 SLC4A1 NM_000342.3(SLC4A1): c.924G> A (p.Leu308=) single nucleotide variant Benign/Likely benign rs5013 GRCh37 Chromosome 17, 42335944: 42335944
28 SLC4A1 NM_000342.3(SLC4A1): c.924G> A (p.Leu308=) single nucleotide variant Benign/Likely benign rs5013 GRCh38 Chromosome 17, 44258576: 44258576
29 SLC4A1 NM_000342.3(SLC4A1): c.113A> C (p.Asp38Ala) single nucleotide variant Benign/Likely benign rs5035 GRCh37 Chromosome 17, 42338998: 42338998
30 SLC4A1 NM_000342.3(SLC4A1): c.113A> C (p.Asp38Ala) single nucleotide variant Benign/Likely benign rs5035 GRCh38 Chromosome 17, 44261630: 44261630
31 SLC4A1 NM_000342.3(SLC4A1): c.16-14G> A single nucleotide variant Benign/Likely benign rs145502796 GRCh38 Chromosome 17, 44262740: 44262740
32 SLC4A1 NM_000342.3(SLC4A1): c.16-14G> A single nucleotide variant Benign/Likely benign rs145502796 GRCh37 Chromosome 17, 42340108: 42340108
33 SLC4A1 NM_000342.3(SLC4A1): c.*1832G> A single nucleotide variant Uncertain significance rs886052988 GRCh37 Chromosome 17, 42325994: 42325994
34 SLC4A1 NM_000342.3(SLC4A1): c.*1832G> A single nucleotide variant Uncertain significance rs886052988 GRCh38 Chromosome 17, 44248626: 44248626
35 SLC4A1 NM_000342.3(SLC4A1): c.*1721G> A single nucleotide variant Likely benign rs62078947 GRCh37 Chromosome 17, 42326105: 42326105
36 SLC4A1 NM_000342.3(SLC4A1): c.*1721G> A single nucleotide variant Likely benign rs62078947 GRCh38 Chromosome 17, 44248737: 44248737
37 SLC4A1 NM_000342.3(SLC4A1): c.*1676A> G single nucleotide variant Uncertain significance rs745898810 GRCh37 Chromosome 17, 42326150: 42326150
38 SLC4A1 NM_000342.3(SLC4A1): c.*1676A> G single nucleotide variant Uncertain significance rs745898810 GRCh38 Chromosome 17, 44248782: 44248782
39 SLC4A1 NM_000342.3(SLC4A1): c.*1606_*1608dupAAA duplication Uncertain significance rs57466226 GRCh37 Chromosome 17, 42326218: 42326220
40 SLC4A1 NM_000342.3(SLC4A1): c.*1606_*1608dupAAA duplication Uncertain significance rs57466226 GRCh38 Chromosome 17, 44248850: 44248852
41 SLC4A1 NM_000342.3(SLC4A1): c.*1608delA deletion Uncertain significance rs57466226 GRCh37 Chromosome 17, 42326218: 42326218
42 SLC4A1 NM_000342.3(SLC4A1): c.*1608delA deletion Uncertain significance rs57466226 GRCh38 Chromosome 17, 44248850: 44248850
43 SLC4A1 NM_000342.3(SLC4A1): c.*1198A> T single nucleotide variant Uncertain significance rs886052992 GRCh38 Chromosome 17, 44249260: 44249260
44 SLC4A1 NM_000342.3(SLC4A1): c.*1198A> T single nucleotide variant Uncertain significance rs886052992 GRCh37 Chromosome 17, 42326628: 42326628
45 SLC4A1 NM_000342.3(SLC4A1): c.*897G> A single nucleotide variant Likely benign rs5030 GRCh38 Chromosome 17, 44249561: 44249561
46 SLC4A1 NM_000342.3(SLC4A1): c.*897G> A single nucleotide variant Likely benign rs5030 GRCh37 Chromosome 17, 42326929: 42326929
47 SLC4A1 NM_000342.3(SLC4A1): c.2210C> T (p.Ala737Val) single nucleotide variant Uncertain significance rs886052997 GRCh38 Chromosome 17, 44253219: 44253219
48 SLC4A1 NM_000342.3(SLC4A1): c.2210C> T (p.Ala737Val) single nucleotide variant Uncertain significance rs886052997 GRCh37 Chromosome 17, 42330587: 42330587
49 SLC4A1 NM_000342.3(SLC4A1): c.1637A> G (p.Asp546Gly) single nucleotide variant Uncertain significance rs886052998 GRCh38 Chromosome 17, 44255836: 44255836
50 SLC4A1 NM_000342.3(SLC4A1): c.1637A> G (p.Asp546Gly) single nucleotide variant Uncertain significance rs886052998 GRCh37 Chromosome 17, 42333204: 42333204

Expression for Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for Hemolytic Anemia

Pathways related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 AK1 ALDOA G6PD GCLC GPI GSS
2
Show member pathways
12.66 ALDOA G6PD GPI HK1 PGK1 PKLR
3
Show member pathways
12.44 ALDOA GPI HK1 PGK1 PKLR
4 12.33 ALDOA G6PD HBB HK1
5
Show member pathways
11.82 ANK1 SPTA1 SPTB
6
Show member pathways
11.76 ALDOA G6PD GPI HK1 PGK1 PKLR
7 11.7 ALDOA HK1 PGK1
8
Show member pathways
11.64 ALDOA HK1 PGK1 PKLR
9 11.48 ALDOA HK1 PGK1
10
Show member pathways
11.47 ALDOA G6PD GPI
11
Show member pathways
11.12 HBB RHAG SLC4A1
12 11.02 ANK1 SPTA1 SPTB
13
Show member pathways
10.66 PGK1 PKLR
14 10.13 G6PD GPI HK1 PGK1
15 10.11 G6PD GPI HK1

GO Terms for Hemolytic Anemia

Cellular components related to Hemolytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.96 AK1 ALDOA CD59 G6PD GPI GSS
2 ficolin-1-rich granule lumen GO:1904813 9.61 ALDOA GPI HBB
3 cytoplasmic side of plasma membrane GO:0009898 9.5 ANK1 G6PD SPTA1
4 spectrin GO:0008091 9.4 SPTA1 SPTB
5 intrinsic component of the cytoplasmic side of the plasma membrane GO:0031235 9.37 SPTA1 SPTB
6 cortical cytoskeleton GO:0030863 9.13 EPB42 SLC4A1 SPTA1
7 spectrin-associated cytoskeleton GO:0014731 8.8 ANK1 SPTA1 SPTB
8 cytosol GO:0005829 10 AK1 ALDOA ANK1 G6PD GCLC GPI

Biological processes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.76 G6PD GPI HK1 PKLR
2 regulation of cell shape GO:0008360 9.73 ALDOA EPB42 SPTA1
3 ER to Golgi vesicle-mediated transport GO:0006888 9.73 ANK1 CD59 SPTA1 SPTB
4 actin filament capping GO:0051693 9.54 SPTA1 SPTB
5 gluconeogenesis GO:0006094 9.54 ALDOA GPI PGK1
6 regulation of blood vessel size GO:0050880 9.52 GCLC HBB
7 glutathione biosynthetic process GO:0006750 9.51 GCLC GSS
8 bicarbonate transport GO:0015701 9.5 HBB RHAG SLC4A1
9 erythrocyte maturation GO:0043249 9.49 EPB42 G6PD
10 response to xenobiotic stimulus GO:0009410 9.48 GCLC GSS
11 response to cadmium ion GO:0046686 9.43 GCLC GPI GSS
12 cellular ion homeostasis GO:0006873 9.4 RHAG SLC4A1
13 glycolytic process GO:0006096 9.35 ALDOA GPI HK1 PGK1 PKLR
14 glucose 6-phosphate metabolic process GO:0051156 9.33 G6PD GPI HK1
15 muscle cell cellular homeostasis GO:0046716 9.25 ALDOA
16 canonical glycolysis GO:0061621 9.02 ALDOA GPI HK1 PGK1 PKLR

Molecular functions related to Hemolytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.87 AK1 EPB42 GCLC GSS HK1 PGK1
2 catalytic activity GO:0003824 9.67 ALDOA GCLC HK1 PKLR
3 magnesium ion binding GO:0000287 9.46 GCLC GSS NT5C3A PKLR
4 glucose binding GO:0005536 9.26 G6PD HK1
5 structural constituent of cytoskeleton GO:0005200 9.26 ANK1 EPB42 SPTA1 SPTB
6 ankyrin binding GO:0030506 8.8 RHAG SLC4A1 SPTB

Sources for Hemolytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
77