HDFN
MCID: HML054
MIFTS: 22

Hemolytic Disease Due to Fetomaternal Alloimmunization (HDFN)

Categories: Blood diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Hemolytic Disease Due to Fetomaternal Alloimmunization

MalaCards integrated aliases for Hemolytic Disease Due to Fetomaternal Alloimmunization:

Name: Hemolytic Disease Due to Fetomaternal Alloimmunization 58
Hemolytic Disease of the Fetus and Newborn 58
Hdfn 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 32 P55 P55.9
ICD10 via Orphanet 33 P55.0 P55.1 P55.8 more
Orphanet 58 ORPHA275938

Summaries for Hemolytic Disease Due to Fetomaternal Alloimmunization

MalaCards based summary : Hemolytic Disease Due to Fetomaternal Alloimmunization, also known as hemolytic disease of the fetus and newborn, is related to retinohepatoendocrinologic syndrome and blood group, gerbich system. An important gene associated with Hemolytic Disease Due to Fetomaternal Alloimmunization is SLC29A1 (Solute Carrier Family 29 Member 1 (Augustine Blood Group)). The drugs Darbepoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and monocytes.

Related Diseases for Hemolytic Disease Due to Fetomaternal Alloimmunization

Diseases related to Hemolytic Disease Due to Fetomaternal Alloimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 retinohepatoendocrinologic syndrome 11.6
2 blood group, gerbich system 11.4
3 fetal erythroblastosis 11.3
4 hydrops fetalis, nonimmune 10.4
5 bilirubin metabolic disorder 10.2
6 posttransplant acute limbic encephalitis 10.2
7 kernicterus 10.1
8 blood group--kell system 10.0
9 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.0
10 yemenite deaf-blind hypopigmentation syndrome 10.0
11 branchiootic syndrome 1 10.0
12 blood group, junior system 10.0
13 deficiency anemia 10.0
14 exanthem 10.0
15 respiratory failure 10.0
16 opioid abuse 10.0
17 thrombocytopenia 10.0
18 cerebral palsy 10.0
19 purpura 10.0
20 hemolytic anemia 10.0
21 hypoglycemia 10.0

Graphical network of the top 20 diseases related to Hemolytic Disease Due to Fetomaternal Alloimmunization:



Diseases related to Hemolytic Disease Due to Fetomaternal Alloimmunization

Symptoms & Phenotypes for Hemolytic Disease Due to Fetomaternal Alloimmunization

Drugs & Therapeutics for Hemolytic Disease Due to Fetomaternal Alloimmunization

Drugs for Hemolytic Disease Due to Fetomaternal Alloimmunization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
2 Hematinics Phase 2, Phase 3
3 Immunoglobulins Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial on the Use of EPO to Reduce Top-up Transfusions in Neonates With Red Blood Cell Alloimmunization Treated With Intrauterine Transfusions Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
2 A Multicenter, Open-label Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Pregnant Women at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn (HDFN) Recruiting NCT03842189 Phase 2 M281
3 Clinical Professor of Shanghai Tongji Hospital Approved for marketing NCT02969174
4 A Multicenter, Prospective Observational Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn Recruiting NCT03755128

Search NIH Clinical Center for Hemolytic Disease Due to Fetomaternal Alloimmunization

Genetic Tests for Hemolytic Disease Due to Fetomaternal Alloimmunization

Anatomical Context for Hemolytic Disease Due to Fetomaternal Alloimmunization

MalaCards organs/tissues related to Hemolytic Disease Due to Fetomaternal Alloimmunization:

40
Testes, Breast, Monocytes, Kidney, B Cells

Publications for Hemolytic Disease Due to Fetomaternal Alloimmunization

Articles related to Hemolytic Disease Due to Fetomaternal Alloimmunization:

(show top 50) (show all 248)
# Title Authors PMID Year
1
Anti-RhD antibody therapy modulates human natural killer cell function. 61
32467141 2020
2
IgG3 anti-Kell allotypic variation results in differential antigen binding and phagocytosis. 61
31930726 2020
3
Impact of intrauterine transfusion on fetal coagulation physiology by thromboelastography. 61
31994748 2020
4
Frequency and clinical significance of red cell antibodies in pregnancy - A prospective study from India. 61
32317523 2020
5
The contribution of iron deficiency to the risk of peripartum transfusion: a retrospective case control study. 61
32252681 2020
6
Resolving Blocked Antigen Phenomenon in Hemolytic Disease of the Fetus and Newborn Due to Anti-K. 61
32209273 2020
7
Next Generation Sequencing-Based Fetal ABO Blood Group Prediction by Analysis of Cell-Free DNA from Maternal Plasma. 61
32110193 2020
8
Potential of Next-Generation Sequencing in Noninvasive Fetal Molecular Blood Group Genotyping. 61
32110190 2020
9
Fatal hemolytic disease of the fetus and newborn caused by anti-Jra antibody: A case report and literature review. 61
31324575 2020
10
Diagnostic value of laboratory monitoring to predict severe hemolytic disease of the fetus and newborn in non-D and non-K-alloimmunized pregnancies. 61
31867744 2020
11
The use of IVIg in fetal and neonatal alloimmune thrombocytopenia- Principles and mechanisms. 61
31926738 2020
12
A case of mild HDFN caused by anti-C, anti-D, and anti-G: Diagnostic strategy and clinical significance of distinguishing anti-G from anti-D and anti-C. 61
31303507 2020
13
Rhesus D alloimmunization in pregnancy from 1996 to 2015 in Iceland: a nation-wide population study prior to routine antenatal anti-D prophylaxis. 61
31850521 2020
14
Clinical value of different anti-D immunoglobulin strategies for preventing Rh hemolytic disease of the fetus and newborn: A network meta-analysis. 61
32163467 2020
15
Suppression of compensatory erythropoiesis in hemolytic disease of the fetus and newborn due to intrauterine transfusions. 61
31978433 2020
16
Cold reacting anti-M causing delayed hemolytic disease of the newborn. 61
31670408 2019
17
Clinical approach after identification of a rare anti-Ena in a prenatal sample. 61
31935334 2019
18
Acute hemolytic transfusion reaction associated with anti-Mta : case report and review of the literature. 61
31503331 2019
19
Coordinating Care Across the Perinatal Continuum in Hemolytic Disease of the Fetus and Newborn: The Timely Handoff of a Positive Maternal Anti-Erythrocyte Antibody Screen. 61
31451186 2019
20
The prenatal intervention of pregnancy complicated with anti-Kell isoimmunization: a review. 61
31571493 2019
21
Blood Donation During Pregnancy Due to Anti-Ku Hemolytic Disease of the Fetus and Newborn. 61
31089725 2019
22
Amplicon Sequencing-Based Noninvasive Fetal Genotyping for RHD-Positive D Antigen-Negative Alleles. 61
31488553 2019
23
Conservative Management of Hyperferritinemia in Hemolytic Disease of the Fetus and Newborn: A Case Report and Review of the Literature. 61
31460887 2019
24
Anemic Disease of the Newborn With Little Increase in Hemolysis and Erythropoiesis Due to Maternal Anti-Jra: A Case Study and Review of the Literature. 61
31227265 2019
25
Heat elution: a modification of the Landsteiner-Miller method. 61
31246486 2019
26
Prevention of hemolytic transfusion reactions with intravenous immunoglobulin prophylaxis in U- patients with anti-U. 61
30861151 2019
27
Transfusion-related red blood cell alloantibodies: induction and consequences. 61
30808636 2019
28
Molecular Detection of Glycophorins A and B Variant Phenotypes and their Clinical Relevance. 61
30910255 2019
29
Identification of red blood cell antibodies in maternal breast milk implicated in prolonged hemolytic disease of the fetus and newborn. 61
30720868 2019
30
Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies. 61
30872329 2019
31
Postponing early intrauterine transfusion with intravenous immunoglobulin treatment: the PETIT study on severe hemolytic disease of the fetus and newborn. 61
30837065 2019
32
Hemolytic disease of the fetus and newborn due to alloanti-M: three Chinese case reports and a review of the literature. 61
30520533 2019
33
Prevalence and specificity of clinically significant red cell alloantibodies in pregnant women - a study from a tertiary care hospital in Southeast Michigan. 61
31692490 2019
34
Bombay phenotype (Oh ) and high-titer anti-H in pregnancy: two case reports and a review of the literature. 61
30260479 2018
35
Sulfhydryl treatment of serum or plasma for the reduction of IgM antibodies. 61
30624946 2018
36
The first case of severe acute hemolytic transfusion reaction caused by anti-Sc2. 61
30299537 2018
37
Neonatal Alloimmune Neutropenia. 61
31049048 2018
38
Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD*148+1T (RHD*01EL.31). 61
30222865 2018
39
Red Blood Cell Alloimmunization in the Pregnant Patient. 61
30097223 2018
40
Predicting anti-Kell-mediated hemolytic disease of the fetus and newborn: diagnostic accuracy of laboratory management. 61
30063902 2018
41
Postponing Early intrauterine Transfusion with Intravenous immunoglobulin Treatment; the PETIT study on severe hemolytic disease of the fetus and newborn. 61
29902448 2018
42
Determination of fetal RHD type in plasma of RhD negative pregnant women. 61
29869532 2018
43
Clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems. 61
30295501 2018
44
Clinical significance of antibodies to antigens in the Scianna, Dombrock, Colton, Landsteiner-Weiner, Chido/Rodgers, H, Kx, Cromer, Gerbich, Knops, Indian, and Ok blood group systems. 61
30295505 2018
45
Frequency of Red Cell Alloantibodies in Pregnant Females of Navsari District: An Experience that Favours Inclusion of Screening for Irregular Erythrocyte Antibody in Routine Antenatal Testing Profile. 61
30065546 2018
46
Predicted S and s phenotypes from genotyping results among Thai populations to prevent transfusion-induced alloimmunization risks. 61
30078741 2018
47
ABO incompatibility and RhIG immunoprophylaxis protect against non-D alloimmunization by pregnancy. 61
29624682 2018
48
Transfusions of least-incompatible blood with intravenous immunoglobulin plus steroids cover in two patients with rare antibody. 61
29732576 2018
49
Clinical significance of antibodies to antigens in the International Society of Blood Transfusion collections, 700 series of low-incidence antigens, and 901 series of high-incidence antigens. 61
29989417 2018
50
Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn. 61
29469208 2018

Variations for Hemolytic Disease Due to Fetomaternal Alloimmunization

ClinVar genetic disease variations for Hemolytic Disease Due to Fetomaternal Alloimmunization:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 SLC29A1 NM_001078177.2(SLC29A1):c.1159A>C (p.Thr387Pro)SNV Pathogenic 429191 rs1131690802 6:44200643-44200643 6:44232906-44232906

Expression for Hemolytic Disease Due to Fetomaternal Alloimmunization

Search GEO for disease gene expression data for Hemolytic Disease Due to Fetomaternal Alloimmunization.

Pathways for Hemolytic Disease Due to Fetomaternal Alloimmunization

GO Terms for Hemolytic Disease Due to Fetomaternal Alloimmunization

Sources for Hemolytic Disease Due to Fetomaternal Alloimmunization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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