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MCID: HMP001
MIFTS: 43

Hemopericardium

Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hemopericardium

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MalaCards integrated aliases for Hemopericardium:

Name: Hemopericardium 12 15 73
Pericardial Effusion 44 73
Haemopericardium 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11482
ICD9CM 35 423.0
MeSH 44 D010490
NCIt 50 C111644
SNOMED-CT 68 23412002
ICD10 33 I31.2
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Summaries for Hemopericardium

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Disease Ontology : 12 A pericardial effusion that results from blood in the pericardial sac.

MalaCards based summary : Hemopericardium, also known as pericardial effusion, is related to pericardial effusion and pericardial effusion, chronic. An important gene associated with Hemopericardium is KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6), and among its related pathways/superpathways are Metformin Pathway, Pharmacodynamics and Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Hemopericardium refers to blood in the pericardial sac of the heart. It is clinically similar to a... more...

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Related Diseases for Hemopericardium

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Diseases related to Hemopericardium via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 327)
# Related Disease Score Top Affiliating Genes
1 pericardial effusion 13.0
2 pericardial effusion, chronic 12.5
3 cantu syndrome 11.5
4 lymphedema, hereditary, iii 11.4
5 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 11.3
6 pericardial tuberculosis 11.3
7 hereditary multiple osteochondromas 11.3
8 cardiac tamponade 10.5
9 hypothyroidism 10.5
10 myocardial infarction 10.5
11 pericarditis 10.4
12 constrictive pericarditis 10.4
13 lymphoma 10.4
14 myxedema 10.3
15 adenocarcinoma 10.3
16 down syndrome 10.2
17 leukemia 10.2
18 cardiac rupture 10.2
19 pulmonary hypertension, primary, 1 10.2
20 small cell cancer of the lung 10.2
21 myocarditis 10.2
22 acute myocardial infarction 10.2
23 scleroderma, familial progressive 10.2
24 endomyocardial fibrosis 10.2
25 pulmonary hypertension 10.1
26 hematopoietic stem cell transplantation 10.1
27 erdheim-chester disease 10.1
28 cardiac diverticulum 10.1
29 lipogranulomatosis 10.1
30 esophageal cancer 10.1
31 hemangioma 10.1
32 kidney disease 10.1
33 pericardial mesothelioma 10.1
34 lung cancer 10.1
35 endocarditis 10.1
36 yellow nail syndrome 10.1
37 myeloma, multiple 10.1
38 lymphocytic leukemia 10.1
39 churg-strauss syndrome 10.1
40 pneumonia 10.1
41 thyroiditis 10.1
42 allergic angiitis 10.1
43 hemangioendothelioma 10.1
44 behcet syndrome 10.0
45 breast cancer 10.0
46 hepatocellular carcinoma 10.0
47 temporal arteritis 10.0
48 lymphoma, hodgkin, classic 10.0
49 langerhans cell histiocytosis 10.0
50 anorexia nervosa 10.0

Comorbidity relations with Hemopericardium via Phenotypic Disease Network (PDN):


Aortic Valve Disease 1 Familial Atrial Fibrillation
Heart Disease Intermediate Coronary Syndrome
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Hemopericardium:



Diseases related to Hemopericardium
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Symptoms & Phenotypes for Hemopericardium

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GenomeRNAi Phenotypes related to Hemopericardium according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.61 SLC22A12
2 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.61 SLC22A12
3 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.61 CYP3A4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.61 CYP3A4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.61 CYP3A4 SLC22A12
6 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.61 CYP3A4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.61 CYP3A4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.61 SLC22A12
9 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00302-A 8.62 KCNK6 PLG
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Drugs & Therapeutics for Hemopericardium

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Drugs for Hemopericardium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
2
Dalteparin Approved Phase 4,Phase 3 9005-49-6
3
Warfarin Approved Phase 4,Not Applicable 81-81-2 6691 54678486
4
Rivaroxaban Approved Phase 4,Phase 3,Phase 2,Not Applicable 366789-02-8
5
Apixaban Approved Phase 4,Not Applicable 503612-47-3 10182969
6
Serine Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 56-45-1 5951
7 calcium heparin Phase 4,Phase 3
8 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable
9 Heparin, Low-Molecular-Weight Phase 4,Phase 3
10 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
11
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
12 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
13 Antithrombins Phase 4,Phase 3,Phase 2,Not Applicable
14 Serine Proteinase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
15 Antithrombin III Phase 4,Phase 3,Phase 2,Not Applicable
16 Dabigatran Phase 4,Not Applicable
17 Calcium, Dietary Phase 3
18 Factor Xa Inhibitors Phase 3,Phase 2,Not Applicable
19
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
20 Analgesics Phase 2
21 Anti-Inflammatory Agents Phase 2
22 Antirheumatic Agents Phase 2
23 Anti-Inflammatory Agents, Non-Steroidal Phase 2
24 Analgesics, Non-Narcotic Phase 2
25 Antipyretics Phase 2
26 Cyclooxygenase Inhibitors Phase 2
27 Peripheral Nervous System Agents Phase 2
28 Platelet Aggregation Inhibitors Phase 2
29 Edoxaban Approved Not Applicable 480449-70-5

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Evaluation of Dalteparin for Long-term (One Year) Treatment of Blood Clots in Subjects With Cancer Completed NCT00942968 Phase 4 dalteparin
2 Dabigatran in Patients With Atrial Fibrillation and Mitral Biological Prostheses Enrolling by invitation NCT03183843 Phase 4 Dabigatran Etexilate;Warfarin
3 Anticoagulation in AF Ablation and Effects on Neurocognitive Function Withdrawn NCT02120560 Phase 4
4 Cancer Associated Thrombosis, a Pilot Treatment Study Using Rivaroxaban Completed NCT02746185 Phase 3 rivaroxaban;Low-molecular-weight heparin
5 Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion Recruiting NCT03630055 Phase 3 Rivaroxaban 15 MG Oral Tablet [Xarelto]
6 Comparative Study of Prophylactic Agent for Venous Thromboembolism After Total Knee Arthroplasty Completed NCT02271399 Phase 2 acetylsalicylic acid;rivaroxaban
7 Temporary Pacemaker in Transcatheter Aortic Valve Implantation Patients Unknown status NCT02768064 Not Applicable
8 Surgical Management of Blood in the Pericardial Sac After Penetrating Trauma Completed NCT00823160 Not Applicable
9 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
10 REnal Sympathetic dEnervaTion as an a Adjunct to Catheter-based VT Ablation Completed NCT01858194 Not Applicable
11 AMPLATZER Cardiac Plug Clinical Trial Completed NCT01118299 Not Applicable
12 Safety and Efficacy of Apixaban in Severe Renal Impairment Recruiting NCT03399305
13 Tryptase Level as a Marker of Complications in Transcatheter Aortic Valve Replacement Recruiting NCT03047681
14 Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation Recruiting NCT03642509 Not Applicable NOAC
15 DANISH-CRT - Does Electric Targeted LV Lead Positioning Improve Outcome in Patients With Heart Failure and Prolonged QRS Recruiting NCT03280862 Not Applicable
16 Ventricular Tachycardia in Ischemic Cardiomyopathy; a Combined Endo-Epicardial Ablation Within the First Procedure Versus a Stepwise Approach Not yet recruiting NCT02358746 Not Applicable

Search NIH Clinical Center for Hemopericardium

Cochrane evidence based reviews: pericardial effusion

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Genetic Tests for Hemopericardium

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Anatomical Context for Hemopericardium

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MalaCards organs/tissues related to Hemopericardium:

41
Heart, Lung, T Cells, Kidney, Myeloid, Thyroid, Liver
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Publications for Hemopericardium

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Articles related to Hemopericardium:

(show top 50) (show all 1315)
# Title Authors Year
1
Pericardial effusion in infective endocarditis: The times they are a-changin'. ( 30301562 )
2019
2
Predictors of hospital discharge in cancer patients with pericardial effusion undergoing surgical pericardial drainage. ( 30466137 )
2019
3
Incidence of pericardial effusion after left atrial appendage closure: The impact of underlying heart rhythm-Data from the EWOLUTION study. ( 29722469 )
2018
4
Possible involvement of IL-6-producing tissue-resident macrophages in early-onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation. ( 29384263 )
2018
5
A Case Series of Two Patients Presenting With Pericardial Effusion as First Manifestation of Non-Small Cell Lung Cancer With <i>BRAF</i> Mutation and Expression Of PD-L1. ( 29760834 )
2018
6
Reply to the letter: &amp;quot;Pericardial effusion in community-acquired pneumonia: casuality or etiology?&amp;quot; ( 29735269 )
2018
7
Pericardial effusion following cardiac surgery. A single-center experience. ( 29171276 )
2018
8
Massive pleural and pericardial effusion due to hypothyroidism in a patient with a surgically treated thyroid-stimulating hormone-producing pituitary adenoma. ( 29757110 )
2018
9
Conservative management of nivolumab-induced pericardial effusion: a case report and review of literature. ( 29761026 )
2018
10
Relevant pericardial effusion caused by cytomegalovirus infection in an immunocompetent patient: a case report. ( 29347961 )
2018
11
Pericardial Effusion in Obstructive Sleep Apnea without Pulmonary Arterial Hypertension and Daily Hypoxemia - is it Unusual? ( 29808980 )
2018
12
Idiopathic Loculated and Septated Pericardial Effusion. ( 29871831 )
2018
13
Recurrent Pericardial Effusion While Receiving Nivolumab for Metastatic Lung Adenocarcinoma: Case Report and Review of the Literature. ( 29937384 )
2018
14
Pleural and pericardial effusion in a long-term PD patient - a defying diagnosisa8c. ( 29231161 )
2018
15
Morphology quiz: Pericardial effusion as first manifestation of malignancy. ( 29732625 )
2018
16
A Rare Case of Hemopericardium From a Ruptured Dissecting Pulmonary Artery Aneurysm: Postmortem Computed Tomography Scan and Autopsy Findings. ( 29120872 )
2018
17
Idiosyncratic Pericardial Effusion Associated With Minoxidil. ( 29746289 )
2018
18
Hemopericardium After TAVR: Assessment. ( 29706568 )
2018
19
Left Atrial Appendage Perforation Does Not Always Mean Pericardial Effusion. ( 29880108 )
2018
20
PCR evaluation of selected vector-borne pathogens in dogs with pericardial effusion. ( 29355984 )
2018
21
Systemic sclerosis: severe pulmonary arterial hypertension and pericardial effusion at diagnosis. ( 29764826 )
2018
22
Massive pericardial effusion without cardiac tamponade due to subclinical hypothyroidism (Hashimoto's disease). ( 29778090 )
2018
23
Treatable massive pericardial effusion and hypertrophic cardiomyopathy in an infant with a novel homozygous ACADVL mutation: A case report. ( 29768383 )
2018
24
Pericardial effusion unrelated to surgery is a predictor of mortality in heart transplant patients. ( 29341061 )
2018
25
Atypical Presentation of a Large Pericardial Effusion after Heart Transplantation in a Patient with Dilated Cardiomyopathy. ( 29429930 )
2018
26
Pericardial effusion as an atypical initial presentation of extra-gonadal nonseminomatous germ cell tumor: a case report and literature review. ( 29492268 )
2018
27
Cough as the sole manifestation of pericardial effusion. ( 29437733 )
2018
28
Massive Hemorrhagic Pericardial Effusion With Cardiac Tamponade as Initial Manifestation of Mixed Connective Tissue Disease. ( 29479391 )
2018
29
Non-small cell lung carcinoma metastatic cells in a pericardial effusion. ( 29714042 )
2018
30
Large pericardial effusion and tamponade in young male with Niemann-Pick disease type C. ( 29898264 )
2018
31
Pericardial effusion in community-acquired pneumonia: Casuality or etiology? ( 29859646 )
2018
32
A rare cause of pericardial effusion due to intracardiac cement embolism. ( 29718318 )
2018
33
Non-operative management is feasible for selected blunt trauma patients with pericardial effusion. ( 29191668 )
2018
34
Non-surgical management in hemodynamically unstable blunt traumatic pericardial effusion: A feasible option for treatment. ( 29980487 )
2018
35
The Intra-Pericardial Paraganglioma Presenting as Ascites and Hemopericardium with Impending Tamponade. ( 29681569 )
2018
36
Safety-pin Induced Hemopericardium and Cardiac Tamponade in an Infant. ( 29978823 )
2018
37
First reported case series in the United States of hemopericardium in patients on apixaban. ( 29876295 )
2018
38
Acute Decompensation after Hemodialysis in a Patient with Pericardial Effusion. ( 29714100 )
2018
39
Autosomal Dominant Polycystic Kidney Disease and Pericardial Effusion. ( 30210723 )
2018
40
Pericardial Effusion due to Infliximab Therapy for Ulcerative Colitis. ( 30533230 )
2018
41
Risk factors of pericardial effusion in native valve infective endocarditis and its influence on outcome: A multicenter prospective cohort study. ( 30122503 )
2018
42
Risk factors for pericardial effusion after chemoradiotherapy for thoracic esophageal cancer-comparison of four-field technique and traditional two opposed fields technique. ( 29659940 )
2018
43
Predictors and Outcome of Pericardial Effusion After Hematopoietic Stem Cell Transplantation in Children. ( 29058031 )
2018
44
Incidence and Management of Hemopericardium: Impact of Changing Trends in Invasive Cardiology. ( 30077202 )
2018
45
Delayed hemopericardium due to non-penetrating chest trauma: a report of new case and literature review. ( 30094767 )
2018
46
Selective use of pericardial window and drainage as sole treatment for hemopericardium from penetrating chest trauma. ( 30234166 )
2018
47
Organized Hemopericardium Mimicking Malignant Tumor: A Case of Spontaneous Pericardial Hematoma In a 23-Year-Old Young Male. ( 30311894 )
2018
48
A case of hypertensive emergency, primary hypothyroidism and large pericardial effusion with early tamponade. ( 30279905 )
2018
49
Massive pericardial effusion caused by hypothyroidism. ( 29636960 )
2018
50
Pericardial effusion as first presentation of disseminated non-Hodgkin's lymphoma. ( 30287628 )
2018
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Variations for Hemopericardium

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Expression for Hemopericardium

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Search GEO for disease gene expression data for Hemopericardium.
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Pathways for Hemopericardium

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Pathways related to Hemopericardium according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metformin Pathway, Pharmacodynamics 61
10.51 CYP3A4 RPTOR
2
Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics 61
9.8 CYP3A4 RPTOR
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GO Terms for Hemopericardium

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Sources for Hemopericardium

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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