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MCID: HMP001
MIFTS: 47

Hemopericardium

Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hemopericardium

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MalaCards integrated aliases for Hemopericardium:

Name: Hemopericardium 12 15 17 71
Pericardial Effusion 44 71
Haemopericardium 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11482
ICD9CM 34 423.0
MeSH 44 D010490
NCIt 50 C111644
SNOMED-CT 67 155339006
ICD10 32 I31.2
UMLS 71 C0019064 C0031039
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Summaries for Hemopericardium

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Disease Ontology : 12 A pericardial effusion that results from blood in the pericardial sac.

MalaCards based summary : Hemopericardium, also known as pericardial effusion, is related to constrictive pericarditis and pericardial effusion. An important gene associated with Hemopericardium is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drugs Diclofenac and Colchicine have been mentioned in the context of this disorder. Affiliated tissues include breast, heart and myeloid, and related phenotypes are cardiovascular system and respiratory system

Wikipedia : 74 Hemopericardium refers to blood in the pericardial sac of the heart. It is clinically similar to a... more...

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Related Diseases for Hemopericardium

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Diseases related to Hemopericardium via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 845)
# Related Disease Score Top Affiliating Genes
1 constrictive pericarditis 30.4 TNNI3 CRP
2 pericardial effusion 30.3 TNNI3 F3 F2 CRP
3 inferior myocardial infarction 30.3 TNNI3 PLG
4 thrombosis 30.2 PLG F3 F2
5 acquired von willebrand syndrome 30.2 F3 F2
6 cardiac tamponade 30.2 TNNI3 PLG F3 F2 CRP
7 esophageal varix 30.1 F3 F2
8 pleural empyema 30.1 PLG F2 CRP
9 aortic dissection 30.1 FBN1 ELN CRP
10 lateral myocardial infarction 30.0 TNNI3 PLG
11 systemic scleroderma 30.0 FBN1 ELN CRP
12 mediastinitis 30.0 F3 F2 CRP
13 endocarditis 30.0 TNNI3 F2 CRP
14 infective endocarditis 29.9 TNNI3 F2 CRP
15 heart aneurysm 29.9 PLG CRP
16 exanthem 29.9 F3 F2 CYP3A4 CRP
17 chronic kidney disease 29.8 TNNI3 F3 ELN CRP
18 hepatitis a 29.8 F3 F2 CYP3A4
19 anuria 29.8 F3 F2 CRP
20 hemophilia b 29.8 FBN1 F3 F2
21 aortitis 29.8 ELN CRP
22 kwashiorkor 29.8 F2 CRP
23 portal hypertension 29.7 F3 F2 ELN
24 aortic aneurysm 29.7 FBN1 ELN CRP
25 varicose veins 29.7 FBN1 F2 ELN
26 facial paralysis 29.7 PLG CRP
27 coronary aneurysm 29.6 PLG CRP
28 pulmonary edema 29.6 TNNI3 F2 CRP
29 cellulitis 29.6 F3 F2 CRP
30 purpura 29.6 F3 F2 CRP
31 antiphospholipid syndrome 29.5 F3 F2 CRP
32 thrombocytosis 29.5 F3 F2 CRP
33 acute myocardial infarction 29.5 TNNI3 PLG F3 CRP
34 hellp syndrome 29.5 F3 F2 CRP
35 intermediate coronary syndrome 29.5 TNNI3 PLG F3 CRP
36 thrombophlebitis 29.5 PLG F3 F2 CRP
37 acute myocarditis 29.5 TNNI3 CRP
38 tricuspid valve insufficiency 29.5 TNNI3 FBN1 F3 F2 CRP
39 pulmonary embolism 29.5 TNNI3 F3 F2 CRP
40 liver cirrhosis 29.5 F3 F2 CYP3A4 CRP
41 hydronephrosis 29.4 PLG FBN1 CRP
42 patent ductus arteriosus 1 29.4 FBN1 ELN CRP
43 essential thrombocythemia 29.3 F3 F2 CRP
44 angina pectoris 29.3 TNNI3 F3 CRP
45 pulmonary hypertension 29.3 TNNI3 PLG F3 F2 ELN CRP
46 intracranial embolism 29.3 PLG F3 F2 CRP
47 dilated cardiomyopathy 29.3 TNNI3 FBN1 F2 ELN CRP
48 vascular disease 29.2 PLG F3 F2 ELN CRP
49 atherosclerosis susceptibility 29.2 F3 ELN CRP
50 thrombocytopenia 29.2 PLG F3 F2 CRP

Comorbidity relations with Hemopericardium via Phenotypic Disease Network (PDN):


Aortic Valve Disease 1 Familial Atrial Fibrillation
Heart Disease Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Hemopericardium:



Diseases related to Hemopericardium
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Symptoms & Phenotypes for Hemopericardium

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MGI Mouse Phenotypes related to Hemopericardium:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CRP F2 F3 FBN1 HEG1 PLG
2 respiratory system MP:0005388 9.1 F2 F3 FBN1 HEG1 PLG TNNI3
Sources

Drugs & Therapeutics for Hemopericardium

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Drugs for Hemopericardium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Colchicine Approved Phase 4 64-86-8 6167 2833
3 Anti-Inflammatory Agents Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Analgesics Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Antimitotic Agents Phase 4
9 Antirheumatic Agents Phase 4
10 Tubulin Modulators Phase 4
11
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
12 Fibrinolytic Agents Phase 3
13 Plasminogen Phase 3
14 Tissue Plasminogen Activator Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Sclerosing Solutions Phase 3
17 Anti-Bacterial Agents Phase 3
18
Bevacizumab Approved, Investigational Phase 2 216974-75-3
19
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
20
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
21 Angiogenesis Inhibitors Phase 2
22 Antineoplastic Agents, Immunological Phase 2
23
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
24 Albumin-Bound Paclitaxel Phase 2
25 Protein Kinase Inhibitors Phase 2
26
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
27 Adjuvants, Immunologic Phase 1
28 Immunologic Factors Phase 1
29 Interleukin-12 Phase 1
30
Carbon monoxide Approved, Investigational 630-08-0 281
31
Nitric Oxide Approved 10102-43-9 145068
32
Aspirin Approved, Vet_approved 50-78-2 2244
33 Kava Approved, Investigational, Nutraceutical 9000-38-8
34 Brimonidine Tartrate 70359-46-5
35 Immunoglobulins
36 Antibodies
37 Antibodies, Monoclonal
38 Respiratory System Agents
39 Anesthetics
40 Tin Fluorides
41 Anticoagulants

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters Unknown status NCT02808897 Phase 4
2 the Post Operative Pericardial Effusion (POPE) Treatment Study Completed NCT00247052 Phase 4 diclofenac;diclofenac;matching placebo
3 Cochicine Treatment for Post- Operative Pericardial Effusion: The POPE 2 Study A Multicenter, Double-blind, Randomized Trial Completed NCT01266694 Phase 4 Colchicines;Placebo
4 Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation Recruiting NCT02260206 Phase 4 Colchicine
5 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial). Unknown status NCT01552187 Phase 3 Colchicine;Placebo
6 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
7 A Randomized Controlled Trial to Evaluate the Efficacy of Intra-pericardial Instillation of a Sclerosing Agent After Pericardial Drainage in Patients With Malignant Pericardial Effusion Associated With Lung Cancer (JCOG9811) Completed NCT00132613 Phase 3 Pericardial instillation of bleomycin after drainage
8 Colchicine in Postoperative Fontan Patients (CPFP) Recruiting NCT03575572 Phase 2, Phase 3 Colchicine
9 Intrapleural Bevacizumab Injection for Treating Malignant Pleural or Pericardial Effusion in Non-small Cell Lung Cancer Completed NCT02054052 Phase 2 Bevacizumab
10 A Phase I/II Study to Investigate the Safety, Tolerability and Potential Activity of IPI-504 in Relapsed and / or Refractory Stage IIIb (With Malignant Pleural or Pericardial Effusion), or Stage IV NSCLC Patients Completed NCT00431015 Phase 1, Phase 2 IPI-504
11 A Phase II Randomized Study of OSI-774 (Erlotinib) (NSC #718781) With or Without Carboplatin/Paclitaxel in Patients With Previously Untreated Adenocarcinoma of the Lung Who Never Smoked or Were Former Light Smokers Completed NCT00126581 Phase 2 Carboplatin;Erlotinib;Erlotinib Hydrochloride;Paclitaxel
12 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
13 Drainage or Pericardiocentesis Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention. Unknown status NCT01665495
14 Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery: A Prospective Randomized Trial Completed NCT00684125
15 Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath Completed NCT02638649
16 The Clinical Impact of an Aggressive Approach Towards Pleural and Pericardial Effusions Following Open Heart Surgery: a Step Towards Standard Guidelines Completed NCT02045641
17 Feasibility and Accuracy of Focused Cardiac Ultrasound Using an FDA Approved Hand-held Ultrasound Device in Outpatient Setting in Our Institution. Completed NCT03887286
18 A Randomized Prospective Study of the Definitive Management of the Stable Haemopericardium Following Penetrating Cardiac Injury Utilising Subxyphoid Window and Drainage. Completed NCT00823160
19 Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP) - A Randomized Study Recruiting NCT04472468
20 Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers Recruiting NCT03902353
21 Monitoring Patients With Acute Dyspnea With Serial Focused Ultrasound of the Heart and the Lungs Recruiting NCT04091334
22 Establishment of Patient Derived Cancer Cell Models to Interrogate Novel Molecular Targets in Metastatic Cancer Recruiting NCT02646228
23 Diagnostic Value of Cell Block Immunohistochemistry in Effusion Cytology Recruiting NCT04279327
24 A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease Recruiting NCT04464655
25 Point-of-care Ultrasound in Finland Recruiting NCT03327688
26 Cardiovascular Manifestation of Inflamatory Bowel Disease Patient ( Tissue Doppler Echocardiography and Cardiac MRI ) Not yet recruiting NCT04656015
27 Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding Not yet recruiting NCT04701749
28 CancerCodeTM Informed, Molecularly Targeted Therapies in Non-small Cell Lung Cancer Terminated NCT02132884 targeted therapy
29 A Randomized, Prospective Study on Point-of-Care Focused Cardiac Ultrasound in Patients Presenting to the Emergency Department With Syncope Terminated NCT01671371

Search NIH Clinical Center for Hemopericardium

Cochrane evidence based reviews: pericardial effusion

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Genetic Tests for Hemopericardium

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Anatomical Context for Hemopericardium

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MalaCards organs/tissues related to Hemopericardium:

40
Breast, Heart, Myeloid, Kidney, Thyroid, Bone Marrow, Brain
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Publications for Hemopericardium

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Articles related to Hemopericardium:

(show top 50) (show all 9375)
# Title Authors PMID Year
1
Acute Pericarditis: Aetiologic Diagnosis and Practical Aspect of the Management. 61
33412346 2021
2
A Pediatric Case Report of Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis With Pericardial Effusion and Multiple Coronary Artery Aneurysms. 61
31688637 2021
3
Cardiac Magnetic Resonance Imaging in Coronavirus Disease 2019 (COVID-19): A Systematic Review of Cardiac Magnetic Resonance Imaging Findings in 199 Patients. 61
33306666 2021
4
Milk of calcium pericardial effusion confirmed with postmortem computed tomography and autopsy findings: A case report. 61
33429330 2021
5
A Fatal Case of Cardiac Contusion After Blunt Chest Injury. 61
32732593 2021
6
Age- and sex-based differences in patients with acute pericarditis. 61
32857868 2021
7
Long-term outcomes with conventional fractionated and stereotactic radiotherapy for suspected heart-base tumours in dogs. 61
33135852 2021
8
Management of patients with myocardial tuberculosis: A case series. 61
33166586 2021
9
Purulent pericarditis-induced intracardiac perforation and infective endocarditis due to Parvimonas micra: a case report. 61
33598614 2021
10
Surgical treatment of a primary cardiac lymphoma presenting with cardiac tamponade. 61
32749598 2021
11
Pericardial effusion and COVID-19. 61
33597055 2021
12
Acute pericarditis revealing COVID-19 infection: Case report. 61
33520219 2021
13
Left ventricular systolic dysfunction with concomitant bradyarrhythmia in a patient with POEMS syndrome: a case report. 61
33598607 2021
14
A staged surgical strategy for cardiogenic shock and iatrogenic ventricular septal perforation due to a malpositioned catheter. 61
32632758 2021
15
Catheter Ablation in Patients With Neuroendocrine (Carcinoid) Tumors and Carcinoid Heart Disease: Outcomes, Peri-Procedural Complications, and Management Strategies. 61
33602395 2021
16
IgA vasculitis presenting as recurrent hemopericardium. 61
32901253 2021
17
Intracardial PMMA bone cement embolism after kyphoplasty-an unusual cause for sudden chest pain, hemothorax and hemopericardium. 61
32607594 2021
18
The role of point-of-care ultrasound in the diagnosis of pericardial effusion: a single academic center retrospective study. 61
33538920 2021
19
Successful Conservative Treatment of Cardiac Rupture Associated with Takotsubo Syndrome. 61
33551402 2021
20
Sinus node disfunction in an adolescent with systemic lupus erythematosus. 61
33215560 2021
21
Frequency and characterization of ancillary chest CT findings in COVID-19 pneumonia. 61
33471553 2021
22
Single center experience of pediatric percutaneous balloon pericardiotomy. 61
33140718 2021
23
[Delayed tamponade: Four cases of rare complication of blunt chest trauma]. 61
33039115 2021
24
Signs of early cardiac tamponade induced by Minoxidil. 61
32778436 2021
25
Cardiac Manifestations, Treatment Characteristics, and Outcomes of Paediatric Inflammatory Multisystem Syndrome Temporally Associated with Severe Acute Respiratory Syndrome Coronavirus-2: systematic review of case reports and case series. 61
33584087 2021
26
Utilization and procedural adverse outcomes associated with Watchman device implantation. 61
32929501 2021
27
Treatment of Metastatic Carcinoma of an Unknown Primary to the Heart with Checkpoint Inhibitor Therapy. 61
33561858 2021
28
Pivotal Study of a Novel Motor Driven Endoscopic Ablation System. 61
33570423 2021
29
[Pericarditis is inflammation of the pericardium, which rheumatologists should know]. 61
33216192 2021
30
Ablation of mitral annular flutter ablation utilizing a left atrial anterior line versus a lateral mitral isthmus line: a systematic review and meta-analysis. 61
33538952 2021
31
Exophytic cavernous hemangioma arising from the right ventricle: Report of a rare case. 61
33559333 2021
32
Transcatheter Embolic Coils to Treat Peri-Device Leaks after Left Atrial Appendage Closure. 61
33549807 2021
33
Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors. 61
33608377 2021
34
Transseptal Puncture Learning Curve for Transcatheter Edge-to-Edge Mitral Valve Repair. 61
33570438 2021
35
Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients With Coronavirus Disease 2019 (from the Yale COVID-19 Cardiovascular Registry). 61
33539857 2021
36
Utility of a Deep-Learning Algorithm to Guide Novices to Acquire Echocardiograms for Limited Diagnostic Use. 61
33599681 2021
37
Complete heart block as a herald sign for cardiac lymphoma. 61
33431472 2021
38
A rare case of anaerobic streptococci endocarditis in a young female with bicuspid aortic valve: case report. 61
33554013 2021
39
Tegafur-uracil-induced pericardial effusion during adjuvant chemotherapy for resected lung adenocarcinoma: A case report. 61
33463035 2021
40
Role of multimodality imaging in evaluation of cardiovascular involvement in COVID-19. 61
33065315 2021
41
Uncommon cause of cardiac tamponade in a young man. 61
33472808 2021
42
Haemophilus influenzae purulent pericarditis in an immunocompetent individual. 61
33552427 2021
43
Pericardial Involvement in Cancer. 61
33460602 2021
44
Preprocedure CT Findings of Right Heart Failure as a Predictor of Mortality After Transcatheter Aortic Valve Replacement. 61
33170737 2021
45
Effusive-constrictive pericarditis in the spectrum of pericardial compressive syndromes. 61
33452122 2021
46
Squamous Cell Carcinoma of Thymus Presenting as Constrictive Pericarditis Diagnosed With 18F-FDG PET/CT. 61
32701799 2021
47
COVID-19 myopericarditis with cardiac tamponade in the absence of respiratory symptoms: a case report. 61
33494822 2021
48
Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe. 61
33166189 2021
49
An atypical chronic neutrophilic leukemia patient harboring ASXL1 and NRAS mutations associated with monoclonal plasma cell dyscrasia presenting as hemopericardium. 61
32052135 2021
50
Central venous-to-arterial CO2 difference is a poor tool to predict adverse outcomes after cardiac surgery: a retrospective study. 61
33403551 2021
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Variations for Hemopericardium

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Expression for Hemopericardium

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Search GEO for disease gene expression data for Hemopericardium.
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Pathways for Hemopericardium

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Pathways related to Hemopericardium according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 11.77 PLG F2 CRP
2
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.33 PLG F3 F2
3
Cell adhesion_Cell-matrix glycoconjugates 23
10.96 PLG ELN
4
Complement and coagulation cascades 36 1
10.96 PLG F3 F2
5
Syndecan-4-mediated signaling events 1
10.81 PLG F2
6
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 65
10.48 PLG F2
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GO Terms for Hemopericardium

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Cellular components related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 PLG HEG1 FBN1 F3 F2 EMCN
2 collagen-containing extracellular matrix GO:0062023 9.02 PLG FBN1 F3 F2 ELN

Biological processes related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.54 TNNI3 HEG1 FBN1
2 cellular protein metabolic process GO:0044267 9.5 PLG FBN1 F2
3 blood coagulation GO:0007596 9.43 PLG F3 F2
4 acute-phase response GO:0006953 9.4 F2 CRP
5 fibrinolysis GO:0042730 9.16 PLG F2
6 negative regulation of fibrinolysis GO:0051918 8.96 PLG F2
7 hemostasis GO:0007599 8.8 PLG F3 F2

Molecular functions related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 PLG F3 F2
2 extracellular matrix constituent conferring elasticity GO:0030023 8.62 FBN1 ELN
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Sources for Hemopericardium

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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