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MCID: HMP001
MIFTS: 46

Hemopericardium

Categories: Blood diseases, Cardiovascular diseases
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Aliases & Classifications for Hemopericardium

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MalaCards integrated aliases for Hemopericardium:

Name: Hemopericardium 11 14 16 71 75 33
Pericardial Effusion 43 71
Haemopericardium 11 33
Haemorrhagic Pericarditis 33
Pericardium Haemorrhage 33
Pneumohemopericardium 33
Haematopericardium 33

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:11482
ICD9CM 34 423.0
MeSH 43 D010490
NCIt 49 C111644
SNOMED-CT 68 155339006
ICD10 31 I31.2
ICD11 33 304055010
UMLS 71 C0019064 C0031039
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Summaries for Hemopericardium

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Disease Ontology: 11 A pericardial effusion that results from blood in the pericardial sac.

MalaCards based summary: Hemopericardium, also known as pericardial effusion, is related to vitamin k deficiency bleeding and myocarditis. An important gene associated with Hemopericardium is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) and Syndecan-4-mediated signaling events. The drugs Colchicine and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and myeloid, and related phenotypes are muscle and cardiovascular system

Wikipedia: 75 Hemopericardium refers to blood in the pericardial sac of the heart. It is clinically similar to a... more...
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Related Diseases for Hemopericardium

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Diseases related to Hemopericardium via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1034)
# Related Disease Score Top Affiliating Genes
1 vitamin k deficiency bleeding 30.6 F3 F2
2 myocarditis 30.6 TNNI3 NPPB F3 F2
3 pericarditis 30.6 TNNI3 NPPB CRP
4 hypothyroidism 30.5 NPPB F3 F2 CYP3A4 CRP
5 mediastinitis 30.4 F3 F2 CRP
6 constrictive pericarditis 30.4 TNNI3 NPPB CRP
7 pericardial effusion 30.3 TNNI3 NPPB F3 F2 CRP
8 exanthem 30.3 F3 F2 CYP3A4 CRP
9 aortitis 30.2 FBN1 CRP
10 behcet syndrome 30.2 F3 F2 CRP
11 hypersensitivity vasculitis 30.2 F2 CRP
12 immunoglobulin light chain amyloidosis 30.2 TNNI3 NPPB
13 acquired von willebrand syndrome 30.2 F3 F2
14 heart cancer 30.2 TNNI3 CRP
15 aortic aneurysm 30.1 FBN1 F3 F2 CRP
16 anuria 30.1 F3 F2 CRP
17 atrioventricular block 30.1 TNNI3 NPPB CRP
18 nephrotic syndrome 30.1 PLG F3 F2 CRP
19 spontaneous tension pneumothorax 30.1 NPPB CRP
20 cardiogenic shock 30.0 PLAT NPPB
21 pleural empyema 30.0 PLG PLAT F2 CRP
22 kwashiorkor 30.0 F2 CRP
23 cardiac sarcoidosis 30.0 NPPB CRP
24 hemolytic-uremic syndrome 30.0 PLG F3 F2
25 endocarditis 30.0 TNNI3 PLAT F2 CRP
26 thrombophilia due to thrombin defect 29.9 PLAT F3 F2
27 diastolic heart failure 29.9 TNNI3 NPPB CRP
28 tricuspid valve stenosis 29.9 NPPB F3
29 third-degree atrioventricular block 29.9 TNNI3 NPPB CRP
30 esophageal varix 29.9 F3 F2 CRP
31 purpura 29.9 F3 F2 CRP
32 restrictive cardiomyopathy 29.9 TNNI3 NPPB CRP
33 cellulitis 29.9 F3 F2 CRP
34 pleural disease 29.9 F3 F2 CRP
35 cardiac arrest 29.9 TNNI3 NPPB CRP
36 thrombocytosis 29.9 F3 F2 CRP
37 heart aneurysm 29.9 NPPB F3 CRP
38 sickle cell anemia 29.9 F3 F2 CRP
39 thrombosis 29.8 PLG PLAT F3 F2
40 von willebrand's disease 29.8 PLAT F3 F2
41 cardiac tamponade 29.8 TNNI3 PLG PLAT NPPB F3 F2
42 hepatitis a 29.8 F3 F2 CYP3A4
43 varicose veins 29.8 PLAT FBN1 F2
44 vascular disease 29.8 PLAT FBN1 F3 F2 CRP
45 hypertensive heart disease 29.8 TNNI3 NPPB CRP
46 bacterial conjunctivitis 29.8 NPPB CRP
47 cardiac tuberculosis 29.8 NPPB CRP
48 hepatic veno-occlusive disease 29.8 PLG PLAT F3
49 urinary tract infection 29.8 F3 F2 CRP
50 respiratory failure 29.8 TNNI3 PLG NPPB F3 F2 CRP

Comorbidity relations with Hemopericardium via Phenotypic Disease Network (PDN):


Aortic Valve Disease 1 Familial Atrial Fibrillation
Heart Disease Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Hemopericardium:



Diseases related to Hemopericardium
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Symptoms & Phenotypes for Hemopericardium

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MGI Mouse Phenotypes related to Hemopericardium:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.76 CYP2J2 F2 F3 FBN1 HEG1 NPPB
2 cardiovascular system MP:0005385 9.65 CRP CYP2J2 F2 F3 FBN1 HEG1
3 respiratory system MP:0005388 9.17 F2 F3 FBN1 HEG1 PLAT PLG
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Drugs & Therapeutics for Hemopericardium

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Drugs for Hemopericardium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colchicine Approved Phase 4 64-86-8 2833 6167
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Cisatracurium Approved, Investigational Phase 4 96946-41-7 62887
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
8
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
9
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
10
Ranitidine Approved, Withdrawn Phase 4 66357-59-3, 82530-72-1, 66357-35-5 3001055 5039
11
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Atropine Approved, Vet_approved Phase 4 101-31-5, 5908-99-6, 51-55-8 3661 154417 174174
15
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
16 Antirheumatic Agents Phase 4
17 Antimitotic Agents Phase 4
18 Tubulin Modulators Phase 4
19 Cyclooxygenase Inhibitors Phase 4
20 Anti-Inflammatory Agents, Non-Steroidal Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Analgesics Phase 4
23 Anti-Inflammatory Agents Phase 4
24
Ranitidine bismuth citrate Phase 4
25 Anesthetics Phase 4
26 Tea Phase 4
27
Plasminogen Approved Phase 3 9001-91-6
28
Bleomycin Approved, Investigational Phase 3 9041-93-4, 11056-06-7 5360373
29 Fibrinolytic Agents Phase 3
30 Tissue Plasminogen Activator Phase 3
31 Anti-Bacterial Agents Phase 3
32 Antibiotics, Antitubercular Phase 3
33 Sclerosing Solutions Phase 3
34
Carboplatin Approved Phase 2 41575-94-4 10339178 38904
35
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
36
Erlotinib Approved, Investigational Phase 2 183319-69-9, 183321-74-6 176870
37
Bevacizumab Approved, Investigational Phase 2 216974-75-3 135329020
38 Albumin-Bound Paclitaxel Phase 2
39 Angiogenesis Inhibitors Phase 2
40 Antineoplastic Agents, Immunological Phase 2
41 Protein Kinase Inhibitors Phase 2
42
Trastuzumab Approved, Investigational Phase 1 180288-69-1
43 Adjuvants, Immunologic Phase 1
44 Interleukin-12 Phase 1
45 Immunologic Factors Phase 1
46 Immunoglobulins
47 Antibodies, Monoclonal
48 Antibodies
49
Brimonidine Tartrate 70359-46-5
50 Respiratory System Agents

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation Unknown status NCT02260206 Phase 4 Colchicine
2 Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters Unknown status NCT02808897 Phase 4
3 the Post Operative Pericardial Effusion (POPE) Treatment Study Completed NCT00247052 Phase 4 diclofenac;matching placebo
4 Cochicine Treatment for Post- Operative Pericardial Effusion: The POPE 2 Study A Multicenter, Double-blind, Randomized Trial Completed NCT01266694 Phase 4 Colchicines;Placebo
5 A Comparative Study Between Thoracic Epidural Anesthesia in Non-Intubated Video-Assisted Thoracoscopes and the Conventional General Anesthesia With One Lung Ventilation Active, not recruiting NCT05077111 Phase 4
6 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
7 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial). Unknown status NCT01552187 Phase 3 Colchicine;Placebo
8 A Randomized Controlled Trial to Evaluate the Efficacy of Intra-pericardial Instillation of a Sclerosing Agent After Pericardial Drainage in Patients With Malignant Pericardial Effusion Associated With Lung Cancer (JCOG9811) Completed NCT00132613 Phase 3 Pericardial instillation of bleomycin after drainage
9 A Phase II Randomized Study of OSI-774 (Erlotinib) (NSC #718781) With or Without Carboplatin/Paclitaxel in Patients With Previously Untreated Adenocarcinoma of the Lung Who Never Smoked or Were Former Light Smokers Completed NCT00126581 Phase 2 Carboplatin;Erlotinib;Erlotinib Hydrochloride;Paclitaxel
10 Intrapleural Bevacizumab Injection for Treating Malignant Pleural or Pericardial Effusion in Non-small Cell Lung Cancer Completed NCT02054052 Phase 2 Bevacizumab
11 A Phase I/II Study to Investigate the Safety, Tolerability and Potential Activity of IPI-504 in Relapsed and / or Refractory Stage IIIb (With Malignant Pleural or Pericardial Effusion), or Stage IV NSCLC Patients Completed NCT00431015 Phase 1, Phase 2 IPI-504
12 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
13 Diagnostic Value of Cell Block Immunohistochemistry in Effusion Cytology Unknown status NCT04279327
14 Drainage or Pericardiocentesis Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention. Unknown status NCT01665495
15 Feasibility and Accuracy of Focused Cardiac Ultrasound Using an FDA Approved Hand-held Ultrasound Device in Outpatient Setting in Our Institution. Completed NCT03887286
16 The Clinical Impact of an Aggressive Approach Towards Pleural and Pericardial Effusions Following Open Heart Surgery: a Step Towards Standard Guidelines Completed NCT02045641
17 Point-of-care Ultrasound in Finland Completed NCT03327688
18 Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery: A Prospective Randomized Trial Completed NCT00684125
19 Surgical Options for Management of Pericardial Effusion Completed NCT05061914
20 A Randomized Prospective Study of the Definitive Management of the Stable Haemopericardium Following Penetrating Cardiac Injury Utilising Subxyphoid Window and Drainage. Completed NCT00823160
21 Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP) - A Randomized Study Recruiting NCT04472468
22 Pericardial Effusion From Acute Myocardial Infarction: Contributing Factors and Prognosis at One Year (EPERICARDIM) Recruiting NCT05146492
23 A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease Recruiting NCT04464655
24 CancerCodeTM Informed, Molecularly Targeted Therapies in Non-small Cell Lung Cancer Terminated NCT02132884 targeted therapy

Search NIH Clinical Center for Hemopericardium

Cochrane evidence based reviews: pericardial effusion

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Genetic Tests for Hemopericardium

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Anatomical Context for Hemopericardium

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Organs/tissues related to Hemopericardium:

MalaCards : Heart, Lung, Myeloid, Lymph Node, Spinal Cord, Bone Marrow, Liver
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Publications for Hemopericardium

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Articles related to Hemopericardium:

(show top 50) (show all 1040)
# Title Authors PMID Year
1
Advances in Trauma Ultrasound. 62
36424037 2023
2
Patient Selection, Techniques, and Complication Mitigation for Epicardial Ventricular Tachycardia Ablation. 62
36396183 2022
3
Sex differences in outcomes of transvenous lead extraction: insights from National Readmission Database. 62
36445605 2022
4
Kissing Viabahn VBX stent graft reconstruction of thoracic central veins for management of superior vena cava syndrome. 62
35843595 2022
5
Transvenous Lead Extraction in Adult Patient with Leads Implanted in Childhood-Is That the Same Procedure as in Other Adult Patients? 62
36361474 2022
6
Postsurgical Left Atrial Compression due to Hemopericardium Resulting in Liver Failure: A Rare Cause of Cardiac Tamponade. 62
36451873 2022
7
Outcomes of Transvenous Extraction of Leads Older Than 20 and 30 Years-A Large Cohort Study. 62
36361063 2022
8
Report on an Italian survey of 72 stuck hemodialysis catheters. 62
36269492 2022
9
Surgical exploration for stable patients with penetrating cardiac box injuries: When and how? A cohort of 155 patients from Marseille area. 62
35125446 2022
10
Prehospital Ultrasound Use to Guide Resuscitative Thoracotomy in Blunt Traumatic Cardiac Arrest. 62
36153149 2022
11
Pericardial tamponade: A comprehensive emergency medicine and echocardiography review. 62
35696801 2022
12
Hemopericardium With Cardiac Tamponade After Percutaneous Vertebroplasty. 62
35929057 2022
13
An Analysis of Traumatic and Non-Traumatic Hemopericardium Using Autopsy Data From a County Medical Examiner. 62
35430907 2022
14
Delayed sternal closure for intractable bleeding after acute type A aortic dissection repair: outcomes and risk factors analyses. 62
35982501 2022
15
Post-mortem CT: A Useful Tool to Confirm a Case of Suspected Sudden Cardiac Death. 62
36134090 2022
16
Safety of Ultrasound-Guided Transversus Thoracis Plane Block in Pediatric Cardiac Surgery: A Retrospective Cohort Study. 62
34991956 2022
17
The Role of Pericardial Window Techniques in the Management of Penetrating Cardiac Injuries in the Hemodynamically Stable Patient: Where Does It Fit in the Current Trauma Algorithm? 62
35339780 2022
18
An abscess of mitral aortic intervalvular fibrosa mimicking an intracardiac mass. 62
35397124 2022
19
Coronary artery to pulmonary artery fistula: Catheter or scalpel? A case report. 62
35870213 2022
20
Disparities in transvenous lead extraction in young adults. 62
35689031 2022
21
Hemopericardium in the Setting of Direct Oral Anticoagulant Use: An Updated Systematic Review. 62
34607787 2022
22
Survivor of Right Atrial Appendage Rupture Following Blunt Chest Trauma. 62
35225003 2022
23
A giant left ventricular pseudo-pseudoaneurysm following myocardial infarction. 62
34982374 2022
24
Left ventricular free-wall rupture: An unusual presentation of non-bacterial thrombotic endocarditis. 62
35575314 2022
25
An Arrow Through the Heart. 62
35501114 2022
26
CT-guided transthoracic pulmonary artery catheterization: an experimental study in a porcine model. 62
35031843 2022
27
Management of massive hemopericardium in the electrophysiology laboratory: The double long sheath technique. 62
35262938 2022
28
Left hemothorax resulting from delayed right ventricular apical pacing lead perforation without hemopericardium, a case report. 62
35286979 2022
29
A Case of Chronic Aortic Dissection With Hemopericardium and Tamponade. 62
35530841 2022
30
Sub-therapeutic colchicine levels in a patient treated for acute pericarditis in the setting of carbamazepine use: A case report. 62
34671997 2022
31
Clinically Ambiguous Hemorrhagic Cardiac Tamponade Associated with Apixaban. 62
35607568 2022
32
Video-Assisted Thoracoscopic Surgery Management of Subacute Retained Blood Syndrome after Cardiac Surgery. 62
34690218 2022
33
Pericardiocentesis in children: 20-year experience at a tertiary children's hospital. 62
34304745 2022
34
Native Coronary Artery Pseudoaneurysm after Coronary Artery Bypass Grafting. 62
35486052 2022
35
Successful management of life-threatening cardiac tamponade by pericardial aspiration in a boy following blunt trauma to the chest. 62
35414577 2022
36
Automated Detection, Segmentation, and Classification of Pericardial Effusions on Chest CT Using a Deep Convolutional Neural Network. 62
35626201 2022
37
Can Milking-Like Effect Be the First Clue of a Ventricular Free Wall Rupture? 62
35419247 2022
38
Three-year extraction experience of a novel substernal extravascular defibrillation lead in sheep. 62
35048393 2022
39
Self-induced hemopericardium using a syringe needle: A rare method of suicide. 62
34991039 2022
40
Large hemopericardium and pericardial tamponade from presumed erosion of a Watchman 2.5 device 1-year postimplantation. 62
36304606 2022
41
Extracorporeal membrane oxygenation in the forensic setting: A series of 19 forensic cases. 62
34741312 2022
42
Hemopericardium with cardiac tamponade as a rare presentation of a massive aortic aneurysm in a young child with autosomal recessive cutis laxa. 62
34845761 2021
43
Association of thoracic cage fractures and pericardial effusion in blunt trauma. 62
34879494 2021
44
Nonskeletal injuries related to cardiopulmonary resuscitation: An autopsy study. 62
34250595 2021
45
Shark fin sign. 62
34621439 2021
46
Sudden death due to cardiac contusion: Forensic implications in a rare pediatric case. 62
33960426 2021
47
Hemopericardium and Cardiac Tamponade After Blunt Thoracic Trauma: A Case Series and the Essential Role of Cardiac Ultrasound. 62
34215473 2021
48
Nonpenetrating trauma resulting in hemopericardium presenting as syncope. 62
34456494 2021
49
A case of mediastinal mesenchymal tumor resembling hemopericardium. 62
34404995 2021
50
Managing Thrombosis and Hemorrhage in a Man with Myocardial Infarction and Traumatic Hemopericardium with Cardiac Tamponade. 62
34379771 2021
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Variations for Hemopericardium

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Expression for Hemopericardium

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Search GEO for disease gene expression data for Hemopericardium.
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Pathways for Hemopericardium

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Pathways related to Hemopericardium according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 66
Show member pathways
 11.92 PLG PLAT F3 F2
2
Syndecan-4-mediated signaling events 61
10.9 PLG F2
3
amb2 Integrin signaling 61
10.83 PLG PLAT
4
A-beta Plaque Formation and APP Metabolism 65
10.68 PLG PLAT
5
Dissolution of Fibrin Clot 66
10.37 PLG PLAT
6
COVID-19, thrombosis and anticoagulation 74
9.8 PLG F2
7
Regorafenib Pathway, Pharmacokinetics 60
9.23 CYP3A4 CYP2J2
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GO Terms for Hemopericardium

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Cellular components related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 PLG PLAT NPPB HEG1 FBN1 F3
2 collagen-containing extracellular matrix GO:0062023 9.28 PLG PLAT FBN1 F3 F2

Biological processes related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.76 PLG PLAT F3 F2
2 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.62 PLG PLAT
3 regulation of body fluid levels GO:0050878 9.54 HEG1 F2
4 hemostasis GO:0007599 9.43 PLG F3 F2
5 fibrinolysis GO:0042730 9.43 PLG PLAT F2
6 negative regulation of fibrinolysis GO:0051918 9.1 PLG PLAT F2

Molecular functions related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 9.26 PLG PLAT F2
2 serine-type endopeptidase activity GO:0004252 9.23 PLG PLAT F3 F2
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Sources for Hemopericardium

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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