MCID: HMP001
MIFTS: 47

Hemopericardium

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Hemopericardium

MalaCards integrated aliases for Hemopericardium:

Name: Hemopericardium 12 15 17 70
Pericardial Effusion 44 70
Haemopericardium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11482
ICD9CM 34 423.0
MeSH 44 D010490
NCIt 50 C111644
SNOMED-CT 67 155339006
ICD10 32 I31.2
UMLS 70 C0019064 C0031039

Summaries for Hemopericardium

Disease Ontology : 12 A pericardial effusion that results from blood in the pericardial sac.

MalaCards based summary : Hemopericardium, also known as pericardial effusion, is related to constrictive pericarditis and pericardial effusion. An important gene associated with Hemopericardium is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Collagen chain trimerization and Selenium Micronutrient Network. The drugs Diclofenac and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and myeloid, and related phenotypes are cardiovascular system and respiratory system

Wikipedia : 73 Hemopericardium refers to blood in the pericardial sac of the heart. It is clinically similar to a... more...

Related Diseases for Hemopericardium

Diseases related to Hemopericardium via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 858)
# Related Disease Score Top Affiliating Genes
1 constrictive pericarditis 30.6 TNNI3 CRP
2 pericardial effusion 30.5 TNNI3 F3 F2 CRP
3 pulmonary hypertension 30.4 PLG F3 F2 CRP
4 aortic dissection 30.3 FBN1 ELN CRP
5 inferior myocardial infarction 30.3 TNNI3 PLG
6 systemic scleroderma 30.3 FBN1 ELN CRP
7 pleural empyema 30.3 PLG F2 CRP
8 endocarditis 30.3 TNNI3 F2 CRP
9 mediastinitis 30.2 F3 F2 CRP
10 acquired von willebrand syndrome 30.2 F3 F2
11 infective endocarditis 30.2 TNNI3 F2 CRP
12 exanthem 30.2 F3 F2 CYP3A4 CRP
13 esophageal varix 30.1 F3 F2
14 heart aneurysm 30.1 PLG CRP
15 lateral myocardial infarction 30.1 TNNI3 PLG
16 acquired hemophilia 30.1 F9 F3
17 acquired hemophilia a 30.1 F9 F3
18 aortitis 30.0 ELN CRP
19 cardiac tamponade 30.0 TNNI3 PLG F9 F3 F2 CRP
20 anuria 30.0 F3 F2 CRP
21 hemolytic-uremic syndrome 30.0 PLG F3 F2
22 kwashiorkor 29.9 F2 CRP
23 liver cirrhosis 29.9 F3 F2 CYP3A4 CRP
24 hepatitis a 29.9 F3 F2 CYP3A4
25 vitamin k deficiency bleeding 29.9 F9 F3 F2
26 hydronephrosis 29.9 PLG FBN1 CRP
27 von willebrand's disease 29.8 F9 F3 F2
28 factor viii deficiency 29.8 F9 F3 F2
29 portal hypertension 29.8 F3 F2 ELN
30 facial paralysis 29.8 PLG CRP
31 thrombosis 29.8 PLG F9 F3 F2
32 coronary aneurysm 29.8 PLG CRP
33 pulmonary edema 29.8 TNNI3 F2 CRP
34 acute myocardial infarction 29.8 TNNI3 PLG F3 CRP
35 varicose veins 29.8 FBN1 F2 ELN
36 cellulitis 29.8 F3 F2 CRP
37 intermediate coronary syndrome 29.8 TNNI3 PLG F3 CRP
38 purpura 29.8 F3 F2 CRP
39 antiphospholipid syndrome 29.7 F3 F2 CRP
40 thrombocytosis 29.7 F3 F2 CRP
41 tricuspid valve insufficiency 29.7 TNNI3 FBN1 F3 F2 CRP
42 thrombophlebitis 29.7 PLG F3 F2 CRP
43 hellp syndrome 29.7 F3 F2 CRP
44 patent ductus arteriosus 1 29.6 FBN1 ELN CRP
45 acute myocarditis 29.6 TNNI3 CRP
46 nephrotic syndrome 29.6 PLG F9 F3 F2 CRP
47 atrial fibrillation 29.6 F9 F2 CRP
48 angina pectoris 29.6 TNNI3 F3 CRP
49 vascular disease 29.5 PLG F3 F2 ELN CRP
50 intracranial embolism 29.5 PLG F3 F2 CRP

Comorbidity relations with Hemopericardium via Phenotypic Disease Network (PDN):


Aortic Valve Disease 1 Familial Atrial Fibrillation
Heart Disease Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Hemopericardium:



Diseases related to Hemopericardium

Symptoms & Phenotypes for Hemopericardium

MGI Mouse Phenotypes related to Hemopericardium:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 CRP F2 F3 F9 FBN1 HEG1
2 respiratory system MP:0005388 9.1 F2 F3 FBN1 HEG1 PLG TNNI3

Drugs & Therapeutics for Hemopericardium

Drugs for Hemopericardium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2 Anti-Inflammatory Agents Phase 4
3 Cyclooxygenase Inhibitors Phase 4
4 Analgesics Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Analgesics, Non-Narcotic Phase 4
7
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
8
Colchicine Approved Phase 2, Phase 3 64-86-8 6167 2833
9 Fibrinolytic Agents Phase 3
10 Plasminogen Phase 3
11 Tissue Plasminogen Activator Phase 3
12 Anti-Bacterial Agents Phase 3
13 Antibiotics, Antitubercular Phase 3
14 Sclerosing Solutions Phase 3
15 Antirheumatic Agents Phase 2, Phase 3
16 Tubulin Modulators Phase 2, Phase 3
17 Antimitotic Agents Phase 2, Phase 3
18
Bevacizumab Approved, Investigational Phase 2 216974-75-3
19
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
20
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
21 Antineoplastic Agents, Immunological Phase 2
22 Angiogenesis Inhibitors Phase 2
23
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
24 Albumin-Bound Paclitaxel Phase 2
25 Protein Kinase Inhibitors Phase 2
26
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
27 Adjuvants, Immunologic Phase 1
28 Immunologic Factors Phase 1
29 Interleukin-12 Phase 1
30
Carbon monoxide Approved, Investigational 630-08-0 281
31
Nitric Oxide Approved 10102-43-9 145068
32
Aspirin Approved, Vet_approved 50-78-2 2244
33 Kava Approved, Investigational, Nutraceutical 9000-38-8
34 Brimonidine Tartrate 70359-46-5
35 Immunoglobulins
36 Antibodies
37 Antibodies, Monoclonal
38 Respiratory System Agents
39 Anticoagulants
40 Anesthetics
41 Tin Fluorides

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation Unknown status NCT02260206 Phase 4 Colchicine
2 Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters Unknown status NCT02808897 Phase 4
3 Cochicine Treatment for Post- Operative Pericardial Effusion: The POPE 2 Study A Multicenter, Double-blind, Randomized Trial Completed NCT01266694 Phase 4 Colchicines;Placebo
4 the Post Operative Pericardial Effusion (POPE) Treatment Study Completed NCT00247052 Phase 4 diclofenac;diclofenac;matching placebo
5 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial). Unknown status NCT01552187 Phase 3 Colchicine;Placebo
6 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
7 A Randomized Controlled Trial to Evaluate the Efficacy of Intra-pericardial Instillation of a Sclerosing Agent After Pericardial Drainage in Patients With Malignant Pericardial Effusion Associated With Lung Cancer (JCOG9811) Completed NCT00132613 Phase 3 Pericardial instillation of bleomycin after drainage
8 Colchicine in Postoperative Fontan Patients (CPFP) Terminated NCT03575572 Phase 2, Phase 3 Colchicine
9 Intrapleural Bevacizumab Injection for Treating Malignant Pleural or Pericardial Effusion in Non-small Cell Lung Cancer Completed NCT02054052 Phase 2 Bevacizumab
10 A Phase I/II Study to Investigate the Safety, Tolerability and Potential Activity of IPI-504 in Relapsed and / or Refractory Stage IIIb (With Malignant Pleural or Pericardial Effusion), or Stage IV NSCLC Patients Completed NCT00431015 Phase 1, Phase 2 IPI-504
11 A Phase II Randomized Study of OSI-774 (Erlotinib) (NSC #718781) With or Without Carboplatin/Paclitaxel in Patients With Previously Untreated Adenocarcinoma of the Lung Who Never Smoked or Were Former Light Smokers Completed NCT00126581 Phase 2 Carboplatin;Erlotinib;Erlotinib Hydrochloride;Paclitaxel
12 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
13 Drainage or Pericardiocentesis Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention. Unknown status NCT01665495
14 Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery: A Prospective Randomized Trial Completed NCT00684125
15 Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath Completed NCT02638649
16 The Clinical Impact of an Aggressive Approach Towards Pleural and Pericardial Effusions Following Open Heart Surgery: a Step Towards Standard Guidelines Completed NCT02045641
17 Feasibility and Accuracy of Focused Cardiac Ultrasound Using an FDA Approved Hand-held Ultrasound Device in Outpatient Setting in Our Institution. Completed NCT03887286
18 A Randomized Prospective Study of the Definitive Management of the Stable Haemopericardium Following Penetrating Cardiac Injury Utilising Subxyphoid Window and Drainage. Completed NCT00823160
19 Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP) - A Randomized Study Recruiting NCT04472468
20 Monitoring Patients With Acute Dyspnea With Serial Focused Ultrasound of the Heart and the Lungs Recruiting NCT04091334
21 Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers Recruiting NCT03902353
22 Establishment of Patient Derived Cancer Cell Models to Interrogate Novel Molecular Targets in Metastatic Cancer Recruiting NCT02646228
23 Diagnostic Value of Cell Block Immunohistochemistry in Effusion Cytology Recruiting NCT04279327
24 A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease Recruiting NCT04464655
25 Point-of-care Ultrasound in Finland Recruiting NCT03327688
26 Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding Not yet recruiting NCT04701749
27 Cardiovascular Manifestation of Inflamatory Bowel Disease Patient ( Tissue Doppler Echocardiography and Cardiac MRI ) Not yet recruiting NCT04656015
28 CancerCodeTM Informed, Molecularly Targeted Therapies in Non-small Cell Lung Cancer Terminated NCT02132884 targeted therapy
29 A Randomized, Prospective Study on Point-of-Care Focused Cardiac Ultrasound in Patients Presenting to the Emergency Department With Syncope Terminated NCT01671371

Search NIH Clinical Center for Hemopericardium

Cochrane evidence based reviews: pericardial effusion

Genetic Tests for Hemopericardium

Anatomical Context for Hemopericardium

MalaCards organs/tissues related to Hemopericardium:

40
Heart, Kidney, Myeloid, Lung, Pituitary, Thyroid, Liver

Publications for Hemopericardium

Articles related to Hemopericardium:

(show top 50) (show all 9507)
# Title Authors PMID Year
1
Pericardial effusion in anti-complement factor H antibody-associated atypical hemolytic uremic syndrome: two case reports. 61
33386505 2021
2
Diagnosis and categorization of malignant effusions: A 6-year review from a single academic institution. 61
32275354 2021
3
Cytohistological correlation in serous effusions using the newly proposed International System for Reporting Serous Fluid Cytopathology: Experience of an oncological center. 61
32339444 2021
4
Central venous-to-arterial CO2 difference is a poor tool to predict adverse outcomes after cardiac surgery: a retrospective study. 61
33403551 2021
5
Pericardial Involvement in Cancer. 61
33460602 2021
6
Hemopericardium in the acute clinical setting: Are we ready for a tailored management approach on the basis of MDCT findings? 61
33136215 2021
7
Pericarditis and Pericardial Effusion in a Patient with Tophaceous Gout. Infection or Complication Due to Deposit of Microcrystals? 61
31523032 2021
8
Myocarditis and intracardiac thrombus due to Henoch-Schönlein purpura: case report and literature review. 61
32789615 2021
9
Case 288: Uhl Anomaly. 61
33750225 2021
10
Cultural adaptation and validation of the Systemic Sclerosis Quality of Life questionnaire into Arabic language. 61
32918142 2021
11
Evaluation of a Focused Cardiac Ultrasound Protocol in a Pediatric Emergency Department. 61
29746359 2021
12
Pediatric multisystem SARS COV2 with versus without cardiac involvement: a multicenter study from Latin America. 61
33791862 2021
13
Primary splenic epithelioid hemangioendothelioma with diffuse metastases revealed by FDG PET/CT imaging: A case report. 61
33787588 2021
14
Acute Pericarditis: Aetiologic Diagnosis and Practical Aspect of the Management. 61
33412346 2021
15
Hemopericardium in an Infant. 61
33078284 2021
16
Left atrial appendage closure device complicated by late-onset pericardial effusion and tamponade: a case report. 61
33693307 2021
17
Pericardial effusion and COVID-19. 61
33597055 2021
18
Pericardial and pleural effusion in an elderly woman with Covid-19 pneumonia: CT findings. 61
33777279 2021
19
A case of Dressler's syndrome successfully treated with colchicine and acetaminophen. 61
33717379 2021
20
Spindle cell sarcoma of the right atrium causing right atrial pseudoaneurysm: a case report and review of the literature. 61
33741020 2021
21
Pericardial-Peritoneal Window as an Alternative Treatment for Large and Recurrent Pericardial Effusion Post-Pericardiotomy. 61
33656833 2021
22
Pericardial effusion uncovering underlying hypothyroidism. 61
33768953 2021
23
[Recurrent severe pericardial effusion and senile cardiac amyloidosis: Usefulness of balloon pericardiotomy]. 61
33775432 2021
24
Milk of calcium pericardial effusion confirmed with postmortem computed tomography and autopsy findings: A case report. 61
33429330 2021
25
Delayed pericardial effusion after left atrial appendage closure with the LAmbre device: importance of a fully open umbrella. 61
33783902 2021
26
A case of mistaken identity: pseudoaneurysm masquerading as pericardial effusion following premature ventricular contraction ablation. 61
33712821 2021
27
Triple Thoracic Injury Caused by Foreign Body Ingestion: A New Approach for Managing an Unusual Case. 61
33658476 2021
28
Delayed PET/CT of Pericardial Synovial Sarcoma. 61
33782303 2021
29
An evidence-based scoring system to diagnose acute rheumatic fever with carditis in children. 61
33667575 2021
30
[Isolated fetal pericardial effusion follow-up: Should we worry?] 61
33781717 2021
31
PIGA Mutations Can Mimic Neonatal Hemochromatosis. 61
33632934 2021
32
Efficacy, safety, and genetic analysis of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small-cell lung cancer: a phase 2b, multicentre, single-arm, open-label study. 61
33780662 2021
33
Management of patients with myocardial tuberculosis: A case series. 61
33166586 2021
34
Malaria and the Heart: JACC State-of-the-Art Review. 61
33632486 2021
35
A Pediatric Case Report of Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis With Pericardial Effusion and Multiple Coronary Artery Aneurysms. 61
31688637 2021
36
Tegafur-uracil-induced pericardial effusion during adjuvant chemotherapy for resected lung adenocarcinoma: A case report. 61
33463035 2021
37
Differences between diabetic and non-diabetic nephropathy patients in cardiac structure and function at the beginning of hemodialysis and their impact on the prediction of mortality. 61
33682505 2021
38
[A clinical analysis of pericardial effusion caused by central venous catheterization in preterm infants]. 61
33691919 2021
39
Resection of primary cardiac angiosarcoma infiltrating the right atrioventricular junction and tricuspid valve: a case report. 61
33743733 2021
40
[PIMS-a new pediatric challenge]. 61
33686311 2021
41
Clinical features of cardiac lymphoma: an analysis of 37 cases. 61
33752450 2021
42
Minimally invasive closure of transthoracic ventricular septal defect: postoperative complications and risk factors. 61
33741014 2021
43
[First Cases of Multisystem Inflammatory Syndrome following SARS-CoV-2 infection in Adults in Germany]. 61
33706390 2021
44
Atrial Wall Thickness and Risk of Hemopericardium in Elderly Women After Catheter Ablation for Atrial Fibrillation. 61
33657832 2021
45
Combined management of esophagopericardial fistula sustained after catheter ablation for atrial fibrillation. 61
33724615 2021
46
Cardiac Tamponade during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis and Anti-DNA Antibody Positivity. 61
33776015 2021
47
Phenotypic Diversity of Cardiomyopathy Caused by an MYBPC3 Frameshift Mutation in a Korean Family: A Case Report. 61
33803538 2021
48
A Fatal Case of Cardiac Contusion After Blunt Chest Injury. 61
32732593 2021
49
Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus. 61
33682659 2021
50
Dynamic monitoring of cardiac foreign body by perioperative echocardiography: A case study. 61
33644881 2021

Variations for Hemopericardium

Expression for Hemopericardium

Search GEO for disease gene expression data for Hemopericardium.

Pathways for Hemopericardium

GO Terms for Hemopericardium

Cellular components related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 PLG FBN1 F9 F3 F2 CRP
2 extracellular region GO:0005576 9.61 PLG HEG1 FBN1 F9 F3 F2
3 collagen-containing extracellular matrix GO:0062023 9.1 PLG FBN1 F9 F3 F2 ELN

Biological processes related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 PLG FBN1 F2
2 fibrinolysis GO:0042730 9.32 PLG F2
3 blood coagulation, intrinsic pathway GO:0007597 9.26 F9 F2
4 blood coagulation GO:0007596 9.26 PLG F9 F3 F2
5 negative regulation of fibrinolysis GO:0051918 9.16 PLG F2
6 hemostasis GO:0007599 8.92 PLG F9 F3 F2

Molecular functions related to Hemopericardium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.55 HEG1 FBN1 F9 F2 CRP
2 serine-type peptidase activity GO:0008236 9.43 PLG F9 F2
3 extracellular matrix constituent conferring elasticity GO:0030023 8.96 FBN1 ELN
4 serine-type endopeptidase activity GO:0004252 8.92 PLG F9 F3 F2

Sources for Hemopericardium

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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