MCID: HMP028
MIFTS: 26

Hemophagocytic Syndrome Associated with an Infection

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hemophagocytic Syndrome Associated with an Infection

MalaCards integrated aliases for Hemophagocytic Syndrome Associated with an Infection:

Name: Hemophagocytic Syndrome Associated with an Infection 60
Virus-Associated Hemophagocytic Syndrome 60
Iahs 60
Vahs 60

Classifications:

Orphanet: 60  
Rare immunological diseases


External Ids:

UMLS via Orphanet 75 C0019068
Orphanet 60 ORPHA158048

Summaries for Hemophagocytic Syndrome Associated with an Infection

MalaCards based summary : Hemophagocytic Syndrome Associated with an Infection, also known as virus-associated hemophagocytic syndrome, is related to right atrial isomerism and histiocytosis. The drugs Miconazole and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver.

Related Diseases for Hemophagocytic Syndrome Associated with an Infection

Diseases related to Hemophagocytic Syndrome Associated with an Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 right atrial isomerism 11.1
2 histiocytosis 10.4
3 malignant histiocytosis 10.4
4 polymorphic reticulosis 10.4
5 compartment syndrome 10.3
6 influenza 10.3
7 pfeiffer syndrome 10.2
8 hepatitis 10.1
9 burns 10.1
10 filariasis 10.1
11 filarial elephantiasis 10.1
12 pure red-cell aplasia 10.1
13 herpes simplex 10.1
14 virus associated hemophagocytic syndrome 10.1
15 systemic lupus erythematosus 10.1
16 hepatitis c virus 10.1
17 dengue virus 10.1
18 leukemia 10.1
19 lymphoma 10.1
20 lymphocytic leukemia 10.1
21 respiratory failure 10.1
22 hepatitis c 10.1
23 chronic active epstein-barr virus infection 10.1
24 kaposi sarcoma 9.9
25 thrombocytopenic purpura, autoimmune 9.9
26 chediak-higashi syndrome 9.9
27 fanconi anemia, complementation group a 9.9
28 hemophagocytic lymphohistiocytosis, familial, 1 9.9
29 aceruloplasminemia 9.9
30 leukemia, acute lymphoblastic 9.9
31 acute lymphocytic leukemia 9.9
32 hepatitis b 9.9
33 neutropenia 9.9
34 ulcerative colitis 9.9
35 swine influenza 9.9
36 epidemic typhus 9.9
37 colitis 9.9
38 multicentric castleman disease 9.9
39 castleman disease 9.9
40 mumps 9.9
41 sarcoma 9.9
42 hepatitis a 9.9
43 scrub typhus 9.9
44 severe acute respiratory syndrome 9.9
45 purpura 9.9
46 pneumonia 9.9
47 periodontitis 9.9
48 measles 9.9
49 rubella 9.9
50 encephalitis 9.9

Graphical network of the top 20 diseases related to Hemophagocytic Syndrome Associated with an Infection:



Diseases related to Hemophagocytic Syndrome Associated with an Infection

Symptoms & Phenotypes for Hemophagocytic Syndrome Associated with an Infection

Drugs & Therapeutics for Hemophagocytic Syndrome Associated with an Infection

Drugs for Hemophagocytic Syndrome Associated with an Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
2
Lenograstim Approved, Investigational Not Applicable 135968-09-1
3
Etoposide Approved Not Applicable 33419-42-0 36462
4
Busulfan Approved, Investigational Not Applicable 55-98-1 2478
5
leucovorin Approved Not Applicable 58-05-9 143 6006
6
Methotrexate Approved Not Applicable 1959-05-2, 59-05-2 126941
7
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
8
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
9
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
10
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
11
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
12
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
13
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
14
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
15 Folate Not Applicable
16 Nucleic Acid Synthesis Inhibitors Not Applicable
17 Immunosuppressive Agents Not Applicable
18 Antimetabolites Not Applicable
19 Folic Acid Antagonists Not Applicable
20 Immunologic Factors Not Applicable
21 Antirheumatic Agents Not Applicable
22 Anti-Infective Agents Not Applicable
23 Antifungal Agents Not Applicable
24 Dermatologic Agents Not Applicable
25 Topoisomerase Inhibitors Not Applicable
26 Vitamin B Complex Not Applicable
27 Antilymphocyte Serum Not Applicable
28 Antineoplastic Agents, Alkylating Not Applicable
29 Calcineurin Inhibitors Not Applicable
30 Antineoplastic Agents, Phytogenic Not Applicable
31 Antimetabolites, Antineoplastic Not Applicable
32 Alkylating Agents Not Applicable
33 Cyclosporins Not Applicable
34 Etoposide phosphate Not Applicable
35 Vitamin B9 Not Applicable
36 Gastrointestinal Agents Not Applicable
37 Hormones Not Applicable
38 glucocorticoids Not Applicable
39 Hormone Antagonists Not Applicable
40 Autonomic Agents Not Applicable
41 Methylprednisolone Acetate Not Applicable
42 Complement System Proteins Not Applicable
43 Prednisolone acetate Not Applicable
44 Protective Agents Not Applicable
45 Peripheral Nervous System Agents Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
47 Antineoplastic Agents, Hormonal Not Applicable
48 Antiemetics Not Applicable
49 Anti-Inflammatory Agents Not Applicable
50 Neuroprotective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders Unknown status NCT00006056 Not Applicable anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;filgrastim;methotrexate
2 Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies Terminated NCT00006054 Not Applicable anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;methotrexate;methylprednisolone;prednisone

Search NIH Clinical Center for Hemophagocytic Syndrome Associated with an Infection

Genetic Tests for Hemophagocytic Syndrome Associated with an Infection

Anatomical Context for Hemophagocytic Syndrome Associated with an Infection

MalaCards organs/tissues related to Hemophagocytic Syndrome Associated with an Infection:

42
Bone, Bone Marrow, Liver, Spleen, T Cells

Publications for Hemophagocytic Syndrome Associated with an Infection

Articles related to Hemophagocytic Syndrome Associated with an Infection:

(show top 50) (show all 92)
# Title Authors Year
1
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature. ( 30510942 )
2018
2
Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection. ( 27883370 )
2016
3
Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. ( 27496079 )
2016
4
Virus-associated hemophagocytic syndrome in renal transplant recipients: report of 2 cases from a single center. ( 25838952 )
2015
5
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome. ( 25941132 )
2015
6
BK virus-associated hemophagocytic syndrome in a renal transplant recipient. ( 24821160 )
2014
7
Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome. ( 23991898 )
2013
8
A case of novel swine influenza A (H1N1) pneumonia complicated with virus-associated hemophagocytic syndrome. ( 22286408 )
2012
9
Repeated Epstein-Barr virus-associated hemophagocytic syndrome in a lupus nephritis patient. ( 22185972 )
2012
10
Ocular findings in a patient with virus-associated hemophagocytic syndrome. ( 22486263 )
2012
11
Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. ( 21628863 )
2011
12
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection. ( 21366922 )
2011
13
Dengue virus associated hemophagocytic syndrome in children: a case report. ( 20853575 )
2010
14
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. ( 20348529 )
2010
15
Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case. ( 19795003 )
2009
16
Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome. ( 19571453 )
2009
17
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. ( 19640781 )
2009
18
Epstein-Barr virus-associated hemophagocytic syndrome mimicking severe sepsis. ( 19561991 )
2008
19
Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. ( 17456768 )
2007
20
Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. ( 17703994 )
2007
21
Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. ( 17893313 )
2007
22
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). ( 17106167 )
2006
23
Late-onset fatal Epstein-Barr virus-associated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia. ( 17189228 )
2006
24
Mumps virus-associated hemophagocytic syndrome. ( 15759337 )
2005
25
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with lupus nephritis. ( 15625619 )
2005
26
Cyclosporin neurotoxicity with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15753052 )
2005
27
Dengue virus-associated hemophagocytic syndrome and dyserythropoiesis: a case report. ( 15754587 )
2005
28
Virus-associated hemophagocytic syndrome in an international traveler as a differential diagnosis of SARS. ( 15897649 )
2005
29
Epstein-Barr virus-associated hemophagocytic syndrome as first presentation of Fanconi anemia. ( 15926162 )
2005
30
Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a non-compromised host; a case report of unusual entity. ( 15086189 )
2004
31
Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15465418 )
2004
32
Latency pattern of Epstein-Barr virus and methylation status in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12767005 )
2003
33
Unusual clinical manifestation of virus-associated hemophagocytic syndrome. ( 14708643 )
2003
34
Viral load in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12363023 )
2002
35
Sequential quantification of Epstein-Barr virus DNA in a case of Epstein-Barr virus-associated hemophagocytic syndrome. ( 12416743 )
2002
36
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura. ( 11475151 )
2001
37
Epstein-Barr virus-associated hemophagocytic syndrome masquerading as lymphoma: a case report. ( 11456362 )
2001
38
No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan. ( 11536244 )
2001
39
CNS involvement of virus-associated hemophagocytic syndrome: MR imaging appearance. ( 10954276 )
2000
40
Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection. ( 10367794 )
1999
41
Clinicopathological findings of virus-associated hemophagocytic syndrome in bone marrow: association with Epstein-Barr virus and apoptosis. ( 10469396 )
1999
42
Liver and spleen MRI findings in virus-associated hemophagocytic syndrome in a patient with acute lymphocytic leukemia. ( 9880630 )
1998
43
Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. ( 9766697 )
1998
44
Virus-associated hemophagocytic syndrome after hepatic resection: a case report. ( 9496516 )
1998
45
Therapy-related AML after successful chemotherapy with low dose etoposide for virus-associated hemophagocytic syndrome. ( 9846019 )
1998
46
Epstein-Barr virus--Associated hemophagocytic syndrome. A cause of fever of unknown origin in human immunodeficiency virus infection. ( 9278614 )
1997
47
Epstein Barr virus associated hemophagocytic syndrome--a case report. ( 9364304 )
1997
48
Epstein-Barr virus induced virus-associated hemophagocytic syndrome and monoclonal TCR-beta rearrangement: a case report. ( 9378473 )
1997
49
Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome. ( 9444599 )
1997
50
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults. ( 9498706 )
1997

Variations for Hemophagocytic Syndrome Associated with an Infection

Expression for Hemophagocytic Syndrome Associated with an Infection

Search GEO for disease gene expression data for Hemophagocytic Syndrome Associated with an Infection.

Pathways for Hemophagocytic Syndrome Associated with an Infection

GO Terms for Hemophagocytic Syndrome Associated with an Infection

Sources for Hemophagocytic Syndrome Associated with an Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
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35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
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45 MeSH
46 MESH via Orphanet
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50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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