MCID: HMP007
MIFTS: 51

Hemophilia

Categories: Blood diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hemophilia

MalaCards integrated aliases for Hemophilia:

Name: Hemophilia 74 52 25 58 36 29 42 3 62 62
Hemophilia, Hereditary 25
Hemophilia, Familial 25
Hemophilia, Nos 71
Hemophilia a 71
Haemophilia 25

Characteristics:

Orphanet epidemiological data:

58
hemophilia
Inheritance: X-linked recessive; Age of onset: Infancy;

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

KEGG 36 H00219
UMLS via Orphanet 72 C0684275
Orphanet 58 ORPHA448
UMLS 71 C0019069 C0684275

Summaries for Hemophilia

Genetics Home Reference : 25 Hemophilia is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases of hemophilia, continuous bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms of hemophilia do not necessarily involve spontaneous bleeding, and the condition may not become apparent until abnormal bleeding occurs following surgery or a serious injury. The major types of this condition are hemophilia A (also known as classic hemophilia or factor VIII deficiency) and hemophilia B (also known as Christmas disease or factor IX deficiency). Although the two types have very similar signs and symptoms, they are caused by mutations in different genes. People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty.

MalaCards based summary : Hemophilia, also known as hemophilia, hereditary, is related to acquired hemophilia and acquired hemophilia a, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Hemophilia is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Complement and coagulation cascades and ECM-receptor interaction. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

NIH Rare Diseases : 52 Hemophilia is a bleeding disorder that slows the blood clotting process. People with this disorder experience prolonged bleeding following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or in the absence of injury. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs . The major types of this disorder are hemophilia A and hemophilia B . Although the two types have very similar signs and symptoms, they are caused by mutations in different genes . People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood, but have few bleeding problems after puberty. Another form of the disorder, acquired hemophilia , is not caused by inherited gene mutations.

MedlinePlus : 42 Hemophilia is a rare disorder in which the blood does not clot normally. It is usually inherited. Hemophilia usually occurs in males. If you have hemophilia, you have little or no clotting factor. Clotting factor is a protein needed for normal blood clotting. Without it, you may bleed for a long time after an injury or accident. You also may bleed into your knees, ankles, and elbows. Bleeding in the joints causes pain and, if not treated, can lead to arthritis. Bleeding in the brain, a very serious complication of hemophilia, requires emergency treatment. The main symptoms of hemophilia are excessive bleeding and easy bruising. Blood tests can tell if you have it. The main treatment is injecting the missing clotting factor into the bloodstream. You may need it on a regular basis, or just when bleeding occurs. NIH: National Heart, Lung, and Blood Institute

CDC : 3 Hemophilia is usually an inherited bleeding disorder in which the blood does not clot properly. People with hemophilia can live full lives and enjoy most of the activities that other people do. If you have hemophilia, or know someone who does, it's important to learn how to stay as healthy as possible.

KEGG : 36 Hemophilia A and B are X-linked recessive disorders which are the most common hereditary hemorrhagic disorders caused by a deficiency or dysfunction of blood coagulation factor VIII (FVIII) and factor IX (FIX), respectively. Von Willebrand disease is caused by quantitative and/or qualitative defects of von Willebrand factor and inherited in both autosomal dominant and recessive manner.

PubMed Health : 62 About hemophilia: Hemophilia (heem-o-FILL-ee-ah) is a rare bleeding disorder in which the blood doesn't clot normally. If you have hemophilia, you may bleed for a longer time than others after an injury. You also may bleed inside your body (internally), especially in your knees, ankles, and elbows. This bleeding can damage your organs and tissues and may be life threatening.

Wikipedia : 74 Haemophilia is a mostly inherited genetic disorder that impairs the body's ability to make blood clots,... more...

Related Diseases for Hemophilia

Diseases in the Hemophilia family:

Hemophilia a Hemophilia B
Acquired Hemophilia Acquired Hemophilia a

Diseases related to Hemophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 807, show less)
# Related Disease Score Top Affiliating Genes
1 acquired hemophilia 34.4 F9 F8
2 acquired hemophilia a 34.3 F9 F8
3 hemophilia b 34.2 F9 F8 F7
4 von willebrand's disease 33.4 F9 F8
5 factor viii deficiency 33.0 LOC106146150 F9 F8 F7
6 factor xi deficiency 32.6 F9 F8 F7
7 hemophilia a 32.3 LOC106146152 LOC106146150 LOC106146144 LOC106146143 F9 F8
8 hemarthrosis 32.2 F9 F8 F7
9 compartment syndrome 30.5 F8 F7
10 hemorrhagic disease 30.4 F9 F8 F7
11 factor vii deficiency 30.2 F9 F8 F7
12 pulmonary embolism 30.1 F9 F8
13 glanzmann thrombasthenia 30.0 F9 F8
14 thrombophilia 29.9 F9 F8 F7
15 thrombophlebitis 29.9 F8 F7
16 thrombophilia due to activated protein c resistance 29.7 F9 F8
17 cardiac tamponade 29.6 F9 F8 F7
18 vitamin k deficiency bleeding 29.6 F9 F8 F7
19 acquired von willebrand syndrome 29.5 F9 F8 F7
20 factor x deficiency 29.5 F9 F7
21 afibrinogenemia, congenital 29.4 F8 F7
22 prothrombin deficiency 29.4 F9 F8 F7
23 disseminated intravascular coagulation 29.3 TFPI F9 F7
24 x-linked recessive disease 29.3 F9 F8
25 thrombosis 29.2 TFPI F9 F8 F7
26 factor v deficiency 29.1 TFPI F9 F8 F7
27 blood coagulation disease 29.0 TFPI F9 F8 F7
28 carotid stenosis 28.8 TFPI F7
29 myocardial infarction 28.6 TFPI F9 F8 F7
30 hemophilia a with vascular abnormality 12.2
31 factor v and factor viii, combined deficiency of, 1 11.6
32 factor v and factor viii, combined deficiency of, 2 11.6
33 hepatitis c 11.5
34 von willebrand disease, type 1 11.5
35 von willebrand disease, type 3 11.5
36 von willebrand disease, type 2 11.5
37 arthropathy 10.8
38 hemophilic arthropathy 10.7
39 acquired immunodeficiency syndrome 10.7
40 human immunodeficiency virus type 1 10.6
41 immune deficiency disease 10.6
42 autoimmune disease 10.5
43 synovitis 10.5
44 hepatitis c virus 10.5
45 hepatitis 10.4
46 rare hemorrhagic disorder 10.4
47 thrombocytopenia 10.4
48 liver disease 10.4
49 purpura 10.3
50 thalassemia 10.3
51 hepatitis b 10.3
52 liver cirrhosis 10.3
53 thrombophilia due to thrombin defect 10.3
54 hepatitis a 10.3
55 chronic pain 10.3
56 bullous pemphigoid 10.2
57 sneddon syndrome 10.2 F9 F8
58 brachydactyly, type d 10.2 F9 F8
59 muscular dystrophy 10.2
60 lymphopenia 10.2
61 varicose veins 10.2
62 hydrocephalus 10.2
63 viral hepatitis 10.2
64 retinal artery occlusion 10.2 F9 F8
65 esophageal varix 10.2
66 nephrotic syndrome 10.2
67 leukemia 10.2
68 lupus erythematosus 10.2
69 kaposi sarcoma 10.1
70 systemic lupus erythematosus 10.1
71 rheumatoid arthritis 10.1
72 lymphocytic leukemia 10.1
73 arthritis 10.1
74 47,xyy 10.1
75 synovial angioma 10.1 F8 F7
76 hepatocellular carcinoma 10.1
77 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
78 lymphoma 10.1
79 thrombocytopenia due to platelet alloimmunization 10.1
80 duodenal ulcer 10.1
81 appendicitis 10.1
82 rapidly involuting congenital hemangioma 10.1
83 thrombotic microangiopathy 10.1
84 muscular dystrophy, duchenne type 10.1
85 leukemia, acute lymphoblastic 3 10.1
86 acute kidney failure 10.1
87 human immunodeficiency virus infectious disease 10.1
88 severe combined immunodeficiency 10.1
89 pemphigus 10.1
90 head injury 10.1
91 adhesive otitis media 10.1 F9 F7
92 leukemia, chronic lymphocytic 10.1
93 thrombocytopenic purpura, autoimmune 10.1
94 aging 10.1
95 deficiency anemia 10.1
96 hemoglobinopathy 10.1
97 hemolytic anemia 10.1
98 paraplegia 10.1
99 t-cell leukemia 10.1
100 septic arthritis 10.1
101 osteoarthritis 10.1
102 measles 10.1
103 vasculitis 10.1
104 splenomegaly 10.1
105 thrombasthenia 10.1
106 coronary heart disease 1 10.1
107 atherosclerosis susceptibility 10.0
108 nephrolithiasis, calcium oxalate 10.0
109 myeloma, multiple 10.0
110 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
111 exanthem 10.0
112 colitis 10.0
113 respiratory failure 10.0
114 hemopericardium 10.0
115 neutropenia 10.0
116 candidiasis 10.0
117 heart septal defect 10.0
118 ischemia 10.0
119 kidney disease 10.0
120 juvenile rheumatoid arthritis 10.0
121 chronic kidney disease 10.0
122 aneurysm 10.0
123 back pain 10.0
124 dysphagia 10.0
125 pik3ca-related overgrowth syndrome 10.0
126 bone disease 10.0
127 vein disease 10.0 F8 F7
128 sickle cell anemia 10.0
129 bone resorption disease 10.0
130 mumps 10.0
131 portal hypertension 10.0
132 arteriovenous malformation 10.0
133 tetanus 10.0
134 gonadal dysgenesis 10.0
135 ventricular septal defect 10.0
136 pneumonia 10.0
137 end stage renal failure 10.0
138 ulcerative colitis 10.0
139 cytokine deficiency 10.0
140 cytomegalovirus infection 10.0
141 overgrowth syndrome 10.0
142 body mass index quantitative trait locus 11 10.0
143 body mass index quantitative trait locus 9 10.0
144 body mass index quantitative trait locus 8 10.0
145 body mass index quantitative trait locus 4 10.0
146 body mass index quantitative trait locus 10 10.0
147 body mass index quantitative trait locus 7 10.0
148 body mass index quantitative trait locus 12 10.0
149 body mass index quantitative trait locus 14 10.0
150 body mass index quantitative trait locus 18 10.0
151 body mass index quantitative trait locus 19 10.0
152 body mass index quantitative trait locus 20 10.0
153 sexual disorder 10.0
154 impotence 10.0
155 creutzfeldt-jakob disease 9.9
156 myositis 9.9
157 osteoporosis 9.9
158 pemphigus vulgaris, familial 9.9
159 anemia, autoimmune hemolytic 9.9
160 cystic fibrosis 9.9
161 factor xii deficiency 9.9
162 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
163 bone mineral density quantitative trait locus 8 9.9
164 bone mineral density quantitative trait locus 15 9.9
165 beta-thalassemia 9.9
166 hyperlipoproteinemia, type iii 9.9
167 inflammatory bowel disease 9.9
168 atrial fibrillation 9.9
169 coronary artery anomaly 9.9
170 iron metabolism disease 9.9
171 idiopathic interstitial pneumonia 9.9
172 turner syndrome 9.9
173 pleural empyema 9.9
174 myositis ossificans 9.9
175 myeloid leukemia 9.9
176 neuropathy 9.9
177 rubella 9.9
178 acute myocardial infarction 9.9
179 sickle cell disease 9.9
180 coarctation of aorta 9.9
181 inflammatory spondylopathy 9.9
182 hemosiderosis 9.9
183 thrombocytosis 9.9
184 adenoma 9.9
185 spondylitis 9.9
186 periodontal ehlers-danlos syndrome 9.9
187 rare hereditary hemochromatosis 9.9
188 factor xiii deficiency 9.9 F9 F8 F7
189 inherited blood coagulation disease 9.9 F9 F8 F7
190 aortic aneurysm, familial abdominal, 1 9.9
191 arteries, anomalies of 9.9
192 burkitt lymphoma 9.9
193 colorectal cancer 9.9
194 esophageal cancer 9.9
195 intussusception 9.9
196 otitis media 9.9
197 prostate cancer 9.9
198 fragile x syndrome 9.9
199 taqi polymorphism 9.9
200 leukemia, acute myeloid 9.9
201 yemenite deaf-blind hypopigmentation syndrome 9.9
202 pulmonary hypertension 9.9
203 pain agnosia 9.9
204 scoliosis 9.9
205 osteonecrosis 9.9
206 hemiplegia 9.9
207 infant gynecomastia 9.9
208 pericardial effusion 9.9
209 hepatic coma 9.9
210 acute leukemia 9.9
211 gynecomastia 9.9
212 quadriplegia 9.9
213 hepatic encephalopathy 9.9
214 toxic shock syndrome 9.9
215 cholera 9.9
216 rheumatic disease 9.9
217 pneumothorax 9.9
218 vascular disease 9.9
219 cerebral palsy 9.9
220 dental caries 9.9
221 transient cerebral ischemia 9.9
222 ankylosis 9.9
223 hemangioma 9.9
224 aortic aneurysm 9.9
225 skin disease 9.9
226 syphilis 9.9
227 femoral neuropathy 9.9
228 pancreatitis 9.9
229 aortic valve insufficiency 9.9
230 combined t cell and b cell immunodeficiency 9.9
231 peroneal nerve paralysis 9.9
232 peptic ulcer disease 9.9
233 peritonitis 9.9
234 cataract 9.9
235 intestinal obstruction 9.9
236 ileus 9.9
237 lung disease 9.9
238 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.9
239 herpes simplex 9.9
240 intermediate coronary syndrome 9.9
241 intracranial hypertension 9.9
242 cholangitis 9.9
243 encephalitis 9.9
244 toxoplasmosis 9.9
245 48,xyyy 9.9
246 mallory-weiss syndrome 9.9
247 encephalopathy 9.9
248 posttransplant acute limbic encephalitis 9.9
249 rare surgical neurologic disease 9.9
250 rare coagulation disorder 9.9
251 bernard-soulier syndrome 9.8 F9 F8 F7
252 spondyloarthropathy 1 9.8
253 multiple sclerosis 9.8
254 temporal arteritis 9.8
255 late-onset retinal degeneration 9.8
256 diffuse large b-cell lymphoma 9.8
257 mantle cell lymphoma 9.8
258 ehlers-danlos syndrome 9.8
259 biliary atresia 9.8
260 autoimmune hepatitis 9.8
261 chronic granulomatous disease 9.8
262 pituitary adenoma 9.8
263 heart valve disease 9.8
264 depression 9.8
265 carpal tunnel syndrome 9.8
266 hemangioma-thrombocytopenia syndrome 9.8
267 renal cell carcinoma, nonpapillary 9.8
268 marfan syndrome 9.8
269 tetralogy of fallot 9.8
270 arachnoid cysts, intracranial 9.8
271 lung cancer 9.8
272 lymphoma, hodgkin, classic 9.8
273 myasthenia gravis 9.8
274 myelofibrosis 9.8
275 pancreatic cancer 9.8
276 adrenoleukodystrophy 9.8
277 lymphoma, non-hodgkin, familial 9.8
278 body mass index quantitative trait locus 1 9.8
279 gastrointestinal stromal tumor 9.8
280 bone mineral density quantitative trait locus 3 9.8
281 psoriatic arthritis 9.8
282 anxiety 9.8
283 intraocular pressure quantitative trait locus 9.8
284 acute promyelocytic leukemia 9.8
285 microvascular complications of diabetes 5 9.8
286 leukemia, acute lymphoblastic 9.8
287 gastric cancer 9.8
288 myelodysplastic syndrome 9.8
289 graft-versus-host disease 9.8
290 membranous nephropathy 9.8
291 dysfibrinogenemia, congenital 9.8
292 mucopolysaccharidosis-plus syndrome 9.8
293 peripheral vascular disease 9.8
294 autoimmune pancreatitis 9.8
295 autosomal recessive disease 9.8
296 peripheral artery disease 9.8
297 ischemic colitis 9.8
298 lymphoblastic lymphoma 9.8
299 neuroretinitis 9.8
300 osteomyelitis 9.8
301 endocarditis 9.8
302 rickets 9.8
303 thrombotic thrombocytopenic purpura 9.8
304 pneumocystosis 9.8
305 heart disease 9.8
306 chondrocalcinosis 9.8
307 portal vein thrombosis 9.8
308 iron deficiency anemia 9.8
309 pancytopenia 9.8
310 dilated cardiomyopathy 9.8
311 esophageal candidiasis 9.8
312 diarrhea 9.8
313 color blindness 9.8
314 squamous cell papilloma 9.8
315 oral candidiasis 9.8
316 sclerosing cholangitis 9.8
317 generalized anxiety disorder 9.8
318 hypothyroidism 9.8
319 urticaria 9.8
320 alcohol use disorder 9.8
321 cryptosporidiosis 9.8
322 pericarditis 9.8
323 cholecystitis 9.8
324 enthesopathy 9.8
325 pharyngitis 9.8
326 basal cell carcinoma 9.8
327 agammaglobulinemia 9.8
328 papilloma 9.8
329 epidermolysis bullosa 9.8
330 acute pancreatitis 9.8
331 glomerulonephritis 9.8
332 pulmonary tuberculosis 9.8
333 antiphospholipid syndrome 9.8
334 teratoma 9.8
335 fibrosarcoma 9.8
336 signet ring cell adenocarcinoma 9.8
337 retinitis 9.8
338 pulmonary fibrosis 9.8
339 gastritis 9.8
340 epidermolysis bullosa acquisita 9.8
341 hepatitis e 9.8
342 ludwig's angina 9.8
343 uremia 9.8
344 urinary tract obstruction 9.8
345 bronchitis 9.8
346 connective tissue disease 9.8
347 inherited metabolic disorder 9.8
348 cerebrovascular disease 9.8
349 active peptic ulcer disease 9.8
350 herpes zoster 9.8
351 chickenpox 9.8
352 learning disability 9.8
353 evans' syndrome 9.8
354 diabetes mellitus 9.8
355 stomatitis 9.8
356 hypereosinophilic syndrome 9.8
357 albinism 9.8
358 adrenomyeloneuropathy 9.8
359 aids dementia complex 9.8
360 fibromatosis 9.8
361 color vision deficiency 9.8
362 cerebral aneurysms 9.8
363 headache 9.8
364 argyria 9.8
365 rare disease in surgical orthopedic 9.8
366 alcohol dependence 9.7
367 cardiac arrhythmia 9.7
368 cerebral cavernous malformations 9.7
369 factors viii, ix and xi, combined deficiency of 9.7
370 noonan syndrome 1 9.7
371 pheochromocytoma 9.7
372 popliteal cyst 9.7
373 porphyria cutanea tarda 9.7
374 prader-willi syndrome 9.7
375 sarcoidosis 1 9.7
376 scleroderma, familial progressive 9.7
377 syringomyelia, noncommunicating isolated 9.7
378 torticollis 9.7
379 trigeminal neuralgia 9.7
380 triiodothyronine receptor auxiliary protein 9.7
381 vitiligo-associated multiple autoimmune disease susceptibility 6 9.7
382 enterocolitis 9.7
383 goodpasture syndrome 9.7
384 shwachman-diamond syndrome 1 9.7
385 wilson disease 9.7
386 x inactivation, familial skewed, 2 9.7
387 allan-herndon-dudley syndrome 9.7
388 aland island eye disease 9.7
389 thrombophilia, x-linked, due to factor ix defect 9.7
390 arts syndrome 9.7
391 46,xy sex reversal 1 9.7
392 retinitis pigmentosa 12 9.7
393 aneurysmal bone cysts 9.7
394 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7
395 hurler syndrome 9.7
396 mycobacterium tuberculosis 1 9.7
397 major depressive disorder 9.7
398 malaria 9.7
399 diabetes mellitus, ketosis-prone 9.7
400 prothrombin deficiency, congenital 9.7
401 protein z deficiency 9.7
402 human herpesvirus 8 9.7
403 leptin deficiency or dysfunction 9.7
404 melioidosis 9.7
405 thrombocytopenia 5 9.7
406 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.7
407 spastic cerebral palsy 9.7
408 chronic venous insufficiency 9.7
409 adrenal gland pheochromocytoma 9.7
410 gallbladder disease 9.7
411 anal fistula 9.7
412 physical disorder 9.7
413 non-alcoholic fatty liver disease 9.7
414 venous insufficiency 9.7
415 esophageal atresia 9.7
416 chronic pyelonephritis 9.7
417 chronic maxillary sinusitis 9.7
418 discitis 9.7
419 sarcoma 9.7
420 pertussis 9.7
421 primary hyperparathyroidism 9.7
422 dieulafoy lesion 9.7
423 dengue disease 9.7
424 acute kidney tubular necrosis 9.7
425 nephrocalcinosis 9.7
426 hereditary hemorrhagic telangiectasia 9.7
427 plasmodium vivax malaria 9.7
428 porphyria 9.7
429 pulmonary sarcoidosis 9.7
430 hyperparathyroidism 9.7
431 premature ejaculation 9.7
432 46 xy gonadal dysgenesis 9.7
433 disease of mental health 9.7
434 mental depression 9.7
435 cystitis 9.7
436 rectum cancer 9.7
437 exostosis 9.7
438 maxillary sinusitis 9.7
439 coagulation protein disease 9.7
440 nocardiosis 9.7
441 post-thrombotic syndrome 9.7
442 dermatitis 9.7
443 prostatic adenoma 9.7
444 endometriosis 9.7
445 membranoproliferative glomerulonephritis 9.7
446 kidney cortex necrosis 9.7
447 adenocarcinoma 9.7
448 glioblastoma multiforme 9.7
449 astrocytoma 9.7
450 papillary carcinoma 9.7
451 tracheal stenosis 9.7
452 rhabdomyosarcoma 9.7
453 syringomyelia 9.7
454 teratocarcinoma 9.7
455 cellulitis 9.7
456 plexopathy 9.7
457 spindle cell sarcoma 9.7
458 ulnar neuropathy 9.7
459 reactive arthritis 9.7
460 hyperthyroidism 9.7
461 perinatal necrotizing enterocolitis 9.7
462 pyomyositis 9.7
463 achalasia 9.7
464 fatty liver disease 9.7
465 fasciitis 9.7
466 necrotizing fasciitis 9.7
467 neurofibroma 9.7
468 hypermobile ehlers-danlos syndrome 9.7
469 47, xxy 9.7
470 aneurysm of sinus of valsalva 9.7
471 catastrophic antiphospholipid syndrome 9.7
472 chronic hiccups 9.7
473 double outlet left ventricle 9.7
474 eosinophilic cystitis 9.7
475 hemorrhagic shock and encephalopathy syndrome 9.7
476 neonatal stroke 9.7
477 plasmablastic lymphoma 9.7
478 pseudo-turner syndrome 9.7
479 foot drop 9.7
480 hypotonia 9.7
481 refractory anemia with excess blasts in transformation 9.7
482 obsolete: atypical teratoid/rhabdoid tumor 9.7
483 moyamoya angiopathy 9.7
484 neurofibromatosis, type ii 9.6
485 angioedema, hereditary, type i 9.6
486 aniridia 1 9.6
487 bladder cancer 9.6
488 breast cancer 9.6
489 cleft palate, isolated 9.6
490 fibromatosis, gingival, 1 9.6
491 fibrosis of extraocular muscles, congenital, 1 9.6
492 gray platelet syndrome 9.6
493 hair whorl 9.6
494 hashimoto thyroiditis 9.6
495 attention deficit-hyperactivity disorder 9.6
496 hypercholesterolemia, familial, 1 9.6
497 endosteal hyperostosis, autosomal dominant 9.6
498 hyperostosis cranialis interna 9.6
499 legg-calve-perthes disease 9.6
500 lipomatosis, multiple 9.6
501 meckel diverticulum 9.6
502 macrodactyly 9.6
503 ocular cicatricial pemphigoid 9.6
504 enchondromatosis, multiple, ollier type 9.6
505 pneumothorax, primary spontaneous 9.6
506 mccune-albright syndrome 9.6
507 immunoglobulin a deficiency 1 9.6
508 factor viii and factor ix, combined deficiency of 9.6
509 b-cell growth factor 9.6
510 proteus syndrome 9.6
511 pulmonary fibrosis, idiopathic 9.6
512 schizophrenia 9.6
513 small cell cancer of the lung 9.6
514 split-hand/foot malformation 1 9.6
515 spondylolisthesis 9.6
516 chromosome 2q35 duplication syndrome 9.6
517 digeorge syndrome 9.6
518 down syndrome 9.6
519 lipoid congenital adrenal hyperplasia 9.6
520 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 9.6
521 australia antigen 9.6
522 chondrosarcoma 9.6
523 complement component 2 deficiency 9.6
524 craniosynostosis with fibular aplasia 9.6
525 crigler-najjar syndrome, type i 9.6
526 dandy-walker syndrome 9.6
527 gaucher disease, type i 9.6
528 hemihyperplasia, isolated 9.6
529 moyamoya disease 1 9.6
530 mucopolysaccharidosis, type vii 9.6
531 multiple pterygium syndrome, lethal type 9.6
532 ocular motor apraxia 9.6
533 osteogenic sarcoma 9.6
534 polycythemia vera 9.6
535 pulmonic stenosis 9.6
536 retinitis pigmentosa 9.6
537 insulin-like growth factor i 9.6
538 sarcoma, synovial 9.6
539 coffin-lowry syndrome 9.6
540 incontinentia pigmenti 9.6
541 retinitis pigmentosa-deafness syndrome 9.6
542 retinitis pigmentosa 11 9.6
543 helicobacter pylori infection 9.6
544 stroke, ischemic 9.6
545 alpha-thalassemia 9.6
546 tricuspid atresia 9.6
547 meningioma, radiation-induced 9.6
548 pulmonary disease, chronic obstructive 9.6
549 allergic rhinitis 9.6
550 meningioma, familial 9.6
551 patent ductus arteriosus 1 9.6
552 ovarian hyperstimulation syndrome 9.6
553 aplastic anemia 9.6
554 retinal cone dystrophy 4 9.6
555 lung cancer susceptibility 3 9.6
556 microvascular complications of diabetes 3 9.6
557 microvascular complications of diabetes 4 9.6
558 microvascular complications of diabetes 6 9.6
559 microvascular complications of diabetes 7 9.6
560 hermansky-pudlak syndrome 6 9.6
561 aspergillosis 9.6
562 stickler syndrome, type iv 9.6
563 psoriasis 14, pustular 9.6
564 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.6
565 aortic valve disease 2 9.6
566 alacrima, achalasia, and mental retardation syndrome 9.6
567 cholangiocarcinoma 9.6
568 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.6
569 hydrops, lactic acidosis, and sideroblastic anemia 9.6
570 helix syndrome 9.6
571 angina pectoris 9.6
572 west syndrome 9.6
573 pemphigus gestationis 9.6
574 invasive aspergillosis 9.6
575 usher syndrome 9.6
576 adult t-cell leukemia 9.6
577 oculocutaneous albinism 9.6
578 chorioamnionitis 9.6
579 sleep apnea 9.6
580 ameloblastoma 9.6
581 interleukin-7 receptor alpha deficiency 9.6
582 immunoglobulin alpha deficiency 9.6
583 clostridium difficile colitis 9.6
584 porencephaly 9.6
585 persistent hyperplastic primary vitreous 9.6
586 persistent generalized lymphadenopathy 9.6
587 cardiac arrest 9.6
588 mastoiditis 9.6
589 gingival fibromatosis 9.6
590 lymphoproliferative syndrome 9.6
591 dextro-looped transposition of the great arteries 9.6
592 obstructive nephropathy 9.6
593 cytomegalovirus retinitis 9.6
594 chronic neutrophilic leukemia 9.6
595 chronic myelomonocytic leukemia 9.6
596 igg4-related disease 9.6
597 myxofibrosarcoma 9.6
598 hypogonadotropic hypogonadism 9.6
599 trypanosomiasis 9.6
600 pleomorphic lipoma 9.6
601 bacterial infectious disease 9.6
602 tonsillitis 9.6
603 nasopharyngitis 9.6
604 microinvasive gastric cancer 9.6
605 charcot-marie-tooth disease 9.6
606 protein-losing enteropathy 9.6
607 separation anxiety disorder 9.6
608 renal hypertension 9.6
609 gastric ulcer 9.6
610 tooth disease 9.6
611 cholesteatoma of middle ear 9.6
612 brucellosis 9.6
613 hydronephrosis 9.6
614 prostatic hypertrophy 9.6
615 t cell deficiency 9.6
616 rabies 9.6
617 spinal meningioma 9.6
618 pyelonephritis 9.6
619 diphtheria 9.6
620 constrictive pericarditis 9.6
621 horner's syndrome 9.6
622 suppurative otitis media 9.6
623 choledocholithiasis 9.6
624 clubfoot 9.6
625 mononeuropathy 9.6
626 ureteral benign neoplasm 9.6
627 esophagitis 9.6
628 conn's syndrome 9.6
629 allergic hypersensitivity disease 9.6
630 lymphocytic choriomeningitis 9.6
631 goiter 9.6
632 dengue hemorrhagic fever 9.6
633 hematocele of tunica vaginalis testis 9.6
634 graves' disease 9.6
635 bronchopneumonia 9.6
636 hemolytic-uremic syndrome 9.6
637 olecranon bursitis 9.6
638 pyloric stenosis 9.6
639 locked-in syndrome 9.6
640 telangiectasis 9.6
641 hereditary spherocytosis 9.6
642 dementia 9.6
643 acute cystitis 9.6
644 nodular goiter 9.6
645 mycoplasma pneumoniae pneumonia 9.6
646 pure red-cell aplasia 9.6
647 osteopetrosis 9.6
648 obstructive jaundice 9.6
649 facial paralysis 9.6
650 amenorrhea 9.6
651 alcoholic liver cirrhosis 9.6
652 obstructive hydrocephalus 9.6
653 frozen shoulder 9.6
654 chronic purulent otitis media 9.6
655 pemphigoid gestationis 9.6
656 dumping syndrome 9.6
657 papilledema 9.6
658 lymphangioma 9.6
659 leber congenital amaurosis 9.6
660 angioedema 9.6
661 communicating hydrocephalus 9.6
662 retinal vein occlusion 9.6
663 histoplasmosis 9.6
664 squamous cell carcinoma 9.6
665 factitious disorder 9.6
666 neuritis 9.6
667 epilepsy 9.6
668 atrial heart septal defect 9.6
669 gaucher's disease 9.6
670 giant cell tumor 9.6
671 hepatitis d 9.6
672 intestinal perforation 9.6
673 constipation 9.6
674 blood platelet disease 9.6
675 essential thrombocythemia 9.6
676 polyclonal hypergammaglobulinemia 9.6
677 arteriosclerosis 9.6
678 central retinal vein occlusion 9.6
679 angiodysplasia 9.6
680 opiate dependence 9.6
681 pigmented villonodular synovitis 9.6
682 acute interstitial pneumonia 9.6
683 hairy cell leukemia 9.6
684 cryoglobulinemia 9.6
685 bursitis 9.6
686 testicular cancer 9.6
687 breast ductal carcinoma 9.6
688 interstitial lung disease 9.6
689 gingivitis 9.6
690 lipid metabolism disorder 9.6
691 lysosomal storage disease 9.6
692 myelitis 9.6
693 vaccinia 9.6
694 carotid artery thrombosis 9.6
695 skin carcinoma 9.6
696 plague 9.6
697 gastric adenocarcinoma 9.6
698 hermansky-pudlak syndrome 9.6
699 pseudohermaphroditism 9.6
700 pancreatic adenocarcinoma 9.6
701 intracranial thrombosis 9.6
702 myopathy 9.6
703 radiculopathy 9.6
704 pustulosis of palm and sole 9.6
705 dyslexia 9.6
706 rhinitis 9.6
707 secretory meningioma 9.6
708 lymphoplasmacyte-rich meningioma 9.6
709 brain edema 9.6
710 intrahepatic cholangiocarcinoma 9.6
711 poliomyelitis 9.6
712 neurotic disorder 9.6
713 thyroid gland disease 9.6
714 ovarian cyst 9.6
715 infertility 9.6
716 hemangioblastoma 9.6
717 sleep disorder 9.6
718 volkmann contracture 9.6
719 eye disease 9.6
720 large intestine cancer 9.6
721 peripheral nervous system disease 9.6
722 anterolateral myocardial infarction 9.6
723 inferior myocardial infarction 9.6
724 congestive heart failure 9.6
725 cll/sll 9.6
726 pulmonary valve stenosis 9.6
727 progressive multifocal leukoencephalopathy 9.6
728 prion disease 9.6
729 spinal stenosis 9.6
730 b-cell lymphoma 9.6
731 thyroiditis 9.6
732 muscular atrophy 9.6
733 childhood leukemia 9.6
734 myocarditis 9.6
735 periodontitis 9.6
736 polycythemia 9.6
737 retinal degeneration 9.6
738 influenza 9.6
739 collagen disease 9.6
740 chronic fatigue syndrome 9.6
741 subacute delirium 9.6
742 bacterial pneumonia 9.6
743 erythema infectiosum 9.6
744 psoriasis 9.6
745 narcolepsy 9.6
746 hepatopulmonary syndrome 9.6
747 amyloidosis 9.6
748 gas gangrene 9.6
749 viral infectious disease 9.6
750 hypopituitarism 9.6
751 meningitis 9.6
752 episodic ataxia 9.6
753 pathologic nystagmus 9.6
754 hemorrhoid 9.6
755 polyarteritis nodosa 9.6
756 alopecia 9.6
757 villonodular synovitis 9.6
758 triple x syndrome 9.6
759 xq28 duplication syndrome, int22h1/int22h2 mediated 9.6
760 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.6
761 anca-associated vasculitis 9.6
762 autoimmune encephalitis 9.6
763 chronic graft versus host disease 9.6
764 dwarfism 9.6
765 eales disease 9.6
766 gardner-diamond syndrome 9.6
767 granulocytopenia 9.6
768 growth hormone deficiency 9.6
769 haemophilus influenzae 9.6
770 homologous wasting disease 9.6
771 mycobacterium avium complex infections 9.6
772 paraneoplastic neurologic disorders 9.6
773 pemphigus foliaceus 9.6
774 pustular psoriasis 9.6
775 pyogenic granuloma 9.6
776 slipped capital femoral epiphysis 9.6
777 soft tissue sarcoma 9.6
778 thrombotic thrombocytopenic purpura, acquired 9.6
779 transverse myelitis 9.6
780 undifferentiated connective tissue disease 9.6
781 hereditary hypophosphatemic rickets 9.6
782 paresthesia 9.6
783 shaken baby syndrome 9.6
784 syncope 9.6
785 whiplash 9.6
786 superficial fibromatosis 9.6
787 monosomy 21 9.6
788 acute transverse myelitis 9.6
789 mandibular arteriovenous malformation 9.6
790 isolated split hand-split foot malformation 9.6
791 anomaly of chromosome 10 9.6
792 solitary rectal ulcer syndrome 9.6
793 rare lymphatic malformation 9.6
794 lymphocytic hypereosinophilic syndrome 9.6
795 ring chromosome 9.6
796 juvenile nasopharyngeal angiofibroma 9.6
797 tafro syndrome 9.6
798 avascular necrosis 9.6
799 paraneoplastic pemphigus 9.6
800 diffuse alveolar hemorrhage 9.6
801 pemphigus erythematosus 9.6
802 cardiogenic shock 9.6
803 monosomy 22 9.6
804 red cell aplasia 9.6
805 thyroid carcinoma 9.6
806 alpha-2-plasmin inhibitor deficiency 9.5 TFPI F8 F7
807 pulmonary artery disease 9.5 TFPI F8 F7

Graphical network of the top 20 diseases related to Hemophilia:



Diseases related to Hemophilia

Symptoms & Phenotypes for Hemophilia

UMLS symptoms related to Hemophilia:


angina pectoris, edema, chest pain

Drugs & Therapeutics for Hemophilia

PubMed Health treatment related to Hemophilia: 62

The main treatment for hemophilia is called replacement therapy . Concentrates of clotting factor VIII (for hemophilia A) or clotting factor IX (for hemophilia B) are slowly dripped or injected into a vein . These infusions help replace the clotting factor that's missing or low. Clotting factor concentrates can be made from human blood . The blood is treated to prevent the spread of diseases, such as hepatitis . With the current methods of screening and treating donated blood, the risk of getting an infectious disease from human clotting factors is very small. To further reduce the risk, you or your child can take clotting factor concentrates that aren't made from human blood . These are called recombinant clotting factors . Clotting factors are easy to store, mix, and use at home—it only takes about 15 minutes to receive the factor. You may have replacement therapy on a regular basis to prevent bleeding . This is called preventive or prophylactic (PRO-fih-lac-tik) therapy. Or, you may only need replacement therapy to stop bleeding when it occurs. This use of the treatment , on an as-needed basis, is called demand therapy. Demand therapy is less intensive and expensive than preventive therapy. However, there's a risk that bleeding will cause damage before you receive the demand therapy.

Drugs for Hemophilia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 202, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
3
Zidovudine Approved Phase 4 30516-87-1 35370
4
Ribavirin Approved Phase 4 36791-04-5 37542
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
6
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
7
Didanosine Approved Phase 4 69655-05-6 50599
8
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
9
Zalcitabine Approved, Investigational Phase 4 7481-89-2 24066
10
Indinavir Approved Phase 4 150378-17-9 5362440
11
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
12
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
13
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
14
rituximab Approved Phase 4 174722-31-7 10201696
15
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
16
Anti-inhibitor coagulant complex Approved, Investigational Phase 4
17 Antithrombins Phase 4
18 Antithrombin III Phase 4
19 Hirudins Phase 4
20 Deamino Arginine Vasopressin Phase 4
21 Protective Agents Phase 4
22 Anti-Infective Agents Phase 4
23 Antimetabolites Phase 4
24 Anti-Retroviral Agents Phase 4
25 Antiviral Agents Phase 4
26 Reverse Transcriptase Inhibitors Phase 4
27 Anti-HIV Agents Phase 4
28 Arginine Vasopressin Phase 4
29 Natriuretic Agents Phase 4
30 Vasopressins Phase 4
31 Adjuvants, Immunologic Phase 4
32 Viscosupplements Phase 4
33 interferons Phase 4
34 Interferon-alpha Phase 4
35 Hylan Phase 4
36 Triamcinolone hexacetonide Phase 4
37 triamcinolone acetonide Phase 4
38 Triamcinolone diacetate Phase 4
39 Vasoconstrictor Agents Phase 4
40 Immunoglobulins Phase 4
41 Antibodies Phase 4
42 Immunologic Factors Phase 4
43 Antineoplastic Agents, Immunological Phase 4
44 Hormone Antagonists Phase 4
45 glucocorticoids Phase 4
46 Hormones Phase 4
47 Antibodies, Bispecific Phase 4
48 Antibodies, Monoclonal Phase 4
49 Antineoplastic Agents, Hormonal Phase 4
50 Vaccines Phase 4
51
Arginine Investigational, Nutraceutical Phase 4 74-79-3 6322
52
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
53
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
54
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
55 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
56
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
57
Polidocanol Approved Phase 2, Phase 3 9002-92-0
58
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
59
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
60 Immunoglobulin Fc Fragments Phase 3
61 HIV Antibodies Phase 3
62 BAX 855 Phase 3
63 Pharmaceutical Solutions Phase 2, Phase 3
64 Gastrointestinal Agents Phase 3
65 Antiemetics Phase 3
66 Methylprednisolone Acetate Phase 3
67 Autonomic Agents Phase 3
68 Neuroprotective Agents Phase 3
69 Thromboplastin Phase 3
70 Lipoprotein-associated coagulation inhibitor Phase 3
71 Cathartics Phase 2, Phase 3
72 Laxatives Phase 2, Phase 3
73 Sclerosing Solutions Phase 2, Phase 3
74 Alkylating Agents Phase 2, Phase 3
75 Immunosuppressive Agents Phase 2, Phase 3
76
Icodextrin Approved, Investigational Phase 2 337376-15-5
77
Oprelvekin Approved, Investigational Phase 2 145941-26-0
78
Ledipasvir Approved Phase 2 1256388-51-8 67505836
79
Sofosbuvir Approved Phase 2 1190307-88-0 45375808
80
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
81
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
82 Omega 3 Fatty Acid Phase 1, Phase 2
83 Liver Extracts Phase 1, Phase 2
84
Rivaroxaban Approved Phase 1 366789-02-8
85
Bevacizumab Approved, Investigational Phase 1 216974-75-3
86
Zinc Approved, Investigational Phase 1 7440-66-6 32051
87
Melphalan Approved Phase 1 148-82-3 4053 460612
88
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
89
Thrombin Approved, Investigational Phase 1
90
Warfarin Approved Phase 1 81-81-2 6691 54678486
91
Dabigatran Investigational Phase 1 211914-51-1
92 Chorionic Gonadotropin Phase 1
93 Poly I-C Phase 1
94 poly(I).poly(c12,U) Phase 1
95 Interferon Inducers Phase 1
96 Antidotes Phase 1
97 Angiogenesis Inhibitors Phase 1
98 Anticoagulants Phase 1
99
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
100
Azathioprine Approved 446-86-6 2265
101
Sulfamethazine Approved, Investigational, Vet_approved 57-68-1 5327
102
Ibuprofen Approved 15687-27-1 3672
103
Sodium citrate Approved, Investigational 68-04-2
104
Histamine Approved, Investigational 51-45-6 774
105
Cefepime Approved, Investigational 88040-23-7 5479537
106
Piperacillin Approved 66258-76-2 43672
107
Ciprofloxacin Approved, Investigational 85721-33-1 2764
108
Fosfomycin Approved 23155-02-4 446987
109
Amikacin Approved, Investigational, Vet_approved 37517-28-5 37768
110
Haloperidol Approved 52-86-8 3559
111
Labetalol Approved 36894-69-6 3869
112
Tobramycin Approved, Investigational 32986-56-4 5496 36294
113
Zolpidem Approved 82626-48-0 5732
114
Tazobactam Approved 89786-04-9 123630
115
Nifedipine Approved 21829-25-4 4485