Hemophilia a (HEMA)

Categories: Blood diseases, Genetic diseases, Immune diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hemophilia a

MalaCards integrated aliases for Hemophilia a:

Name: Hemophilia a 57 73 25 20 58 72 13 54 6 39 70
Factor Viii Deficiency 25 20 58 72 70
Hemophilia, Classic 57 20
Factor 8 Deficiency 20 72
Classic Hemophilia 20 72
Mild Hemophilia a 58 6
Hema 57 72
Symptomatic Form of Hemophilia a in Female Carriers 58
Severe Hereditary Factor Viii Deficiency Disease 70
Mild Hereditary Factor Viii Deficiency Disease 70
Moderately Severe Factor Viii Deficiency 58
Moderately Severe Hemophilia a 58
Severe Factor Viii Deficiency 58
Mild Factor Viii Deficiency 58
Hemophilia a, Congenital 20
Classical Hemophilia 20
Severe Hemophilia a 58
Fviii Deficiency 58
Haemophilia a 20
Hem a 20


Orphanet epidemiological data:

hemophilia a
Inheritance: X-linked recessive; Prevalence: 1-9/100000 (France),1-9/100000 (Europe); Age of onset: Infancy,Neonatal;
mild hemophilia a
Inheritance: X-linked recessive; Age of onset: Infancy,Neonatal;
severe hemophilia a
Inheritance: X-linked recessive; Age of onset: Infancy,Neonatal;
moderately severe hemophilia a
Inheritance: X-linked recessive; Age of onset: Infancy,Neonatal;
symptomatic form of hemophilia a in female carriers
Inheritance: X-linked recessive;


57 (Updated 20-May-2021)
persistent bleeding after trauma
partial factor viii deficiency in heterozygous carriers

x-linked recessive


hemophilia a:
Inheritance x-linked recessive inheritance


Penetrance All males with an f8 pathogenic variant will be affected and will have approximately the same severity of disease as other affected males in the family. however, other genetic and environmental effects may modify the clinical severity to some extent....


Orphanet: 58  
Rare haematological diseases

Summaries for Hemophilia a

GARD : 20 Hemophilia A is an inherited bleeding disorder in which the blood does not clot normally. People with hemophilia A will bleed more than normal after an injury, surgery, or dental procedure. This disorder can be severe, moderate, or mild. In severe cases, heavy bleeding occurs after minor injury or even when there is no injury (spontaneous bleeding). Bleeding into the joints, muscles, brain, or organs can cause pain and other serious complications. In milder forms, there is no spontaneous bleeding, and the disorder might only be diagnosed after a surgery or serious injury. Hemophilia A is caused by having low levels of a protein called factor VIII. Factor VIII is needed to form blood clots. The disorder is inherited in an X-linked recessive manner and is caused by changes ( mutations ) in the F8 gene. The diagnosis of hemophilia A is made through clinical symptoms and specific laboratory tests to measure the amount of clotting factors in the blood. The main treatment is replacement therapy, during which clotting factor VIII is dripped or injected slowly into a vein. Hemophilia A mainly affects males. With treatment, most people with this disorder do well. Some people with severe hemophilia A may have a shortened lifespan due to the presence of other health conditions and rare complications of the disorder.

MalaCards based summary : Hemophilia a, also known as factor viii deficiency, is related to von willebrand disease, type 3 and von willebrand disease, type 2. An important gene associated with Hemophilia a is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Iron and Ferrous fumarate have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and heart, and related phenotypes are arthralgia and joint swelling

OMIM® : 57 Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency in the activity of coagulation factor VIII. The disorder is clinically heterogeneous with variable severity, depending on the plasma levels of coagulation factor VIII: mild, with levels 6 to 30% of normal; moderate, with levels 2 to 5% of normal; and severe, with levels less than 1% of normal. Patients with mild hemophilia usually bleed excessively only after trauma or surgery, whereas those with severe hemophilia have an annual average of 20 to 30 episodes of spontaneous or excessive bleeding after minor trauma, particularly into joints and muscles. These symptoms differ substantially from those of bleeding disorders due to platelet defects or von Willebrand disease (193400), in which mucosal bleeding predominates (review by Mannucci and Tuddenham, 2001). (306700) (Updated 20-May-2021)

UniProtKB/Swiss-Prot : 72 Hemophilia A: A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery.

Wikipedia : 73 Haemophilia A (or hemophilia A) is a genetic deficiency in clotting factor VIII, which causes increased... more...

GeneReviews: NBK1404

Related Diseases for Hemophilia a

Diseases in the Hemophilia family:

Hemophilia a Hemophilia B
Acquired Hemophilia Acquired Hemophilia a

Diseases related to Hemophilia a via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 649)
# Related Disease Score Top Affiliating Genes
1 von willebrand disease, type 3 31.7 VWF F8
2 von willebrand disease, type 2 31.7 VWF F8
3 von willebrand disease, type 1 31.7 VWF F8
4 acquired hemophilia a 31.3 F9 F8A1 F8 F5 F3
5 hemophilia 31.3 LOC106146152 LOC106146151 LOC106146150 LOC106146144 LOC106146143 F9
6 hemophilia b 31.0 VWF F9 F8 F7 F3
7 factor v and factor viii, combined deficiency of, 2 30.8 F8 F5
8 thrombotic microangiopathy 30.5 VWF F3
9 acquired hemophilia 30.4 F9 F8A1 F8 F5 F3
10 compartment syndrome 30.3 F8 F7 F3
11 factor viii deficiency 30.3 VWF LOC106146150 FUNDC2 F9 F8A1 F8
12 von willebrand's disease 30.2 VWF F9 F8 F7 F3
13 hemarthrosis 30.0 VWF F9 F8 F7 F3
14 hemopericardium 30.0 F9 F3
15 aortic valve insufficiency 29.8 VWF F3
16 carotid artery thrombosis 29.7 VWF F3
17 factor vii deficiency 29.6 F9 F8 F7 F3
18 angiodysplasia 29.6 VWF F8 F3
19 intermediate coronary syndrome 29.5 VWF F3
20 acute myocardial infarction 29.5 VWF F7 F3
21 thrombophilia due to thrombin defect 29.5 VWF F8 F5 F3
22 active peptic ulcer disease 29.5 VWF F7 F3
23 x-linked recessive disease 29.5 VWF F9 F8 F3
24 portal vein thrombosis 29.5 F7 F5
25 pulmonary embolism 29.4 VWF F9 F8 F5 F3
26 intracranial hypertension 29.4 F9 F5 F3
27 vascular disease 29.4 VWF F8 F5 F3
28 cardiac tamponade 29.3 F9 F8 F7 F3
29 moyamoya disease 1 29.3 VWF FUNDC2 F3
30 acquired von willebrand syndrome 29.3 VWF F8 F7 F3
31 peripheral vascular disease 29.3 VWF F5 F3
32 afibrinogenemia, congenital 29.3 VWF F8 F7 F3
33 thrombocytopenia 29.3 VWF F9 F8 F7 F5 F3
34 thrombosis 29.2 VWF F9 F8 F7 F5 F3
35 hemorrhagic disease 29.2 VWF F9 F8 F7 F5 F3
36 intracranial thrombosis 29.2 VWF F8 F5 F3
37 thrombophilia due to activated protein c resistance 29.2 VWF F8 F5 F3
38 blood platelet disease 29.1 VWF F8 F7 F3
39 disseminated intravascular coagulation 29.0 VWF F9 F7 F5 F3
40 cerebrovascular disease 29.0 VWF F8 F7 F5
41 factor x deficiency 28.9 F9 F7 F5 F3
42 thrombophilia 28.8 VWF F9 F8 F7 F5 F3
43 factor xii deficiency 28.8 VWF F9 F7 F5 F3
44 myocardial infarction 28.8 VWF F9 F8 F7 F5 F3
45 blood coagulation disease 28.7 VWF F9 F8 F7 F5 F3
46 thrombophlebitis 28.7 VWF F8 F7 F5 F3
47 stroke, ischemic 28.5 VWF F9 F7 F5 F3
48 factor v deficiency 28.4 VWF F9 F8 F7 F5 F3
49 factor xi deficiency 28.4 VWF F9 F8 F7 F5 F3
50 immunodeficiency 32a 11.5

Comorbidity relations with Hemophilia a via Phenotypic Disease Network (PDN):

Deficiency Anemia

Graphical network of the top 20 diseases related to Hemophilia a:

Diseases related to Hemophilia a

Symptoms & Phenotypes for Hemophilia a

Human phenotypes related to Hemophilia a:

58 31 (show all 46)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 58 31 occasional (7.5%) Very frequent (99-80%),Frequent (79-30%),Occasional (29-5%) HP:0002829
2 joint swelling 58 31 frequent (33%) Very frequent (99-80%),Occasional (29-5%),Frequent (79-30%) HP:0001386
3 bruising susceptibility 58 31 frequent (33%) Very frequent (99-80%),Frequent (79-30%) HP:0000978
4 bleeding with minor or no trauma 58 31 frequent (33%) Very frequent (99-80%),Frequent (79-30%) HP:0011889
5 reduced factor viii activity 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%),Very frequent (99-80%),Very frequent (99-80%) HP:0003125
6 prolonged partial thromboplastin time 58 31 hallmark (90%) Very frequent (99-80%),Occasional (29-5%),Very frequent (99-80%) HP:0003645
7 epistaxis 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0000421
8 gingival bleeding 58 31 frequent (33%) Frequent (79-30%) HP:0000225
9 spontaneous hematomas 58 31 very rare (1%) Frequent (79-30%),Very rare (<4-1%),Very rare (<4-1%) HP:0007420
10 poor wound healing 58 31 frequent (33%) Frequent (79-30%) HP:0001058
11 thromboembolism 58 31 frequent (33%) Frequent (79-30%) HP:0001907
12 menorrhagia 58 31 occasional (7.5%) Frequent (79-30%),Occasional (29-5%) HP:0000132
13 post-partum hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0011891
14 oral cavity bleeding 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0030140
15 intramuscular hematoma 58 31 occasional (7.5%) Occasional (29-5%),Frequent (79-30%),Occasional (29-5%) HP:0012233
16 joint hemorrhage 58 31 frequent (33%) Occasional (29-5%),Frequent (79-30%),Occasional (29-5%),Frequent (79-30%) HP:0005261
17 persistent bleeding after trauma 58 31 frequent (33%) Frequent (79-30%) HP:0001934
18 prolonged bleeding after dental extraction 58 31 occasional (7.5%) Occasional (29-5%),Frequent (79-30%) HP:0006298
19 prolonged bleeding after surgery 58 31 frequent (33%) Occasional (29-5%),Frequent (79-30%),Frequent (79-30%) HP:0004846
20 anemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001903
21 hematuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000790
22 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%),Occasional (29-5%) HP:0002239
23 abnormality of the elbow 58 31 occasional (7.5%) Occasional (29-5%) HP:0009811
24 headache 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0002315
25 limitation of joint mobility 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0001376
26 cartilage destruction 58 31 occasional (7.5%) Occasional (29-5%) HP:0100773
27 synovitis 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0100769
28 arthropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0003040
29 macroscopic hematuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0012587
30 cephalohematoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0012541
31 intraventricular hemorrhage 58 31 very rare (1%) Occasional (29-5%),Very rare (<4-1%) HP:0030746
32 prolonged bleeding following circumcision 58 31 occasional (7.5%) Occasional (29-5%) HP:0030137
33 limb joint contracture 58 31 occasional (7.5%) Occasional (29-5%) HP:0003121
34 epidural hemorrhage 58 31 occasional (7.5%) Very rare (<4-1%),Occasional (29-5%) HP:0100310
35 subdural hemorrhage 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0100309
36 progressive joint destruction 58 31 occasional (7.5%) Occasional (29-5%) HP:0005187
37 reduced von willebrand factor activity 58 31 occasional (7.5%) Occasional (29-5%) HP:0008330
38 hip contracture 58 31 very rare (1%) Very rare (<4-1%) HP:0003273
39 splenic rupture 58 31 very rare (1%) Very rare (<4-1%) HP:0012223
40 seizure 31 very rare (1%) HP:0001250
41 seizures 58 Very rare (<4-1%)
42 intracranial hemorrhage 58 Very rare (<4-1%),Occasional (29-5%),Occasional (29-5%)
43 osteoarthritis 31 HP:0002758
44 subcutaneous hemorrhage 58 Frequent (79-30%)
45 abnormal bleeding 58 Very frequent (99-80%),Frequent (79-30%)
46 prolonged bleeding following procedure 58 Frequent (79-30%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Laboratory Abnormalities:
factor viii deficiency
platelet count normal
ptt prolonged
pt normal
bleeding time normal
Skeletal Limbs:
degenerative joint disease

Skin Nails Hair Skin:
ecchymoses common
petechiae and purpura do not occur

Clinical features from OMIM®:

306700 (Updated 20-May-2021)

Drugs & Therapeutics for Hemophilia a

Drugs for Hemophilia a (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 274)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Iron Approved Phase 4 7439-89-6 23925 29936
Ferrous fumarate Approved Phase 4 141-01-5
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
Ribavirin Approved Phase 4 36791-04-5 37542
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
Zidovudine Approved Phase 4 30516-87-1 35370
Didanosine Approved Phase 4 69655-05-6 50599
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
Indinavir Approved Phase 4 150378-17-9 5362440
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
Zalcitabine Approved, Investigational Phase 4 7481-89-2 24066
Voriconazole Approved Phase 4 137234-62-9 71616
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
21 Micronutrients Phase 4
22 Trace Elements Phase 4
23 Chelating Agents Phase 4
24 Iron Supplement Phase 4
25 Iron Chelating Agents Phase 4
26 Vasopressins Phase 4
27 Arginine Vasopressin Phase 4
28 Deamino Arginine Vasopressin Phase 4
29 HIV Protease Inhibitors Phase 4
protease inhibitors Phase 4
31 Antifungal Agents Phase 4
32 Anti-Infective Agents Phase 4
33 Antimetabolites Phase 4
34 Hormones Phase 4
35 Hormone Antagonists Phase 4
36 Antiviral Agents Phase 4
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38 interferons Phase 4
39 Interferon-alpha Phase 4
40 Hylan Phase 4
41 Triamcinolone hexacetonide Phase 4
42 Triamcinolone diacetate Phase 4
43 triamcinolone acetonide Phase 4
44 Reverse Transcriptase Inhibitors Phase 4
45 Anti-HIV Agents Phase 4
46 Anti-Retroviral Agents Phase 4
47 Cytochrome P-450 CYP3A Inhibitors Phase 4
48 Antibodies, Bispecific Phase 4
49 Hemostatics Phase 4
50 BAX 855 Phase 4

Interventional clinical trials:

(show top 50) (show all 724)
# Name Status NCT ID Phase Drugs
1 DDAVP vs Exercise in Patients With Mild Hemophilia A - Which is Better and do They Work Synergistically in Improving Hemostasis? Unknown status NCT03136003 Phase 4 DDAVP
2 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
4 Hematology Oncology Center Unknown status NCT02999308 Phase 4
5 Beijing Children's Hospital, Capital Medical University Unknown status NCT03598725 Phase 4 Coagulation Factor VIII;Prednisone;Rituximab
6 Amino Acid Chelated Iron Versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia With Pregnancy: Randomized Controlled Trial Unknown status NCT03830034 Phase 4 Amino Acid chelated iron tab 15 mg;Ferrous Fumarate tab 350 mg( 115 mg elemental iron)
8 Antihemophilic Factor (Recombinant) Plasma/Albumin-Free Method (rAHF PFM): A Phase 3/4, Prospective, Controlled, Randomized, Multi-Center Study to Compare the Efficacy and Safety of Continuous Infusion (CI) Versus Intermittent Bolus Infusion (BI) in Subjects With Severe or Moderately Severe Hemophilia A Undergoing Major Orthopedic Surgery Completed NCT00357656 Phase 4 Recombinant Protein-Free Factor VIII (rAHF-PFM);Recombinant Protein-Free Factor VIII (rAHF-PFM)
9 Advate Antihemophilic Factor (Recombinant), Plasma/Albumin Free Method (ADVATE rAHF-PFM): A Phase 4 Study Comparing Two Prophylactic Regimens in Subjects With Severe or Moderately Severe Hemophilia A Completed NCT00243386 Phase 4 Antihemophilic factor, recombinant, manufactured protein-free;Antihemophilic factor, recombinant, manufactured protein-free
10 Whole Blood Clot Stability and Thrombin Generating Capacity Following Treatment With Bypassing Agents (BPA) With and Without and Tranexamic Acid (TXA) in Haemophilia A Patients With inhibitor-an In-vivo Prospective Crossover Study Completed NCT01800435 Phase 4 aPCC, aPCC + TXA;rFVIIa, rFVIIa + TXA
12 Moderate Term Musculoskeletal Outcomes With Escalating Dose Prophylaxis: the Canadian Hemophilia Prophylaxis Study Follow-up Study Completed NCT01085344 Phase 4
13 An Open-Label, Randomized, Parallel, Multicenter Trial Comparing the Safety and Efficacy of rFVIIa When Administered as i.v. Bolus or i.v. Continuous Infusion to Hemophiliacs With Inhibitors During and After Major Surgery Completed NCT01561391 Phase 4 activated recombinant human factor VII;activated recombinant human factor VII;factor VIII
14 Exercise Versus DDAVP in Patients With Mild Hemophilia A - is One Non-inferior to the Other and do They Work Additively in Improving Hemostasis? Completed NCT03379974 Phase 4 DDAVP Inhalant Product
15 A Non-randomized, Open-label Study To Evaluate The Pharmacokinetics, Safety And Efficacy Of Refacto Af In Previously Treated Pediatric Subjects Less Than Twelve Years Of Age With Severe Hemophilia A (Fviii:c <1%). Completed NCT00914459 Phase 4
16 Comparison of Different Prophylaxis Regimens for Moderate to Severe Hemophilia A Pediatric Patients Completed NCT02727647 Phase 4 FVIII;FVIII
17 Pharmacokinetic Comparison of 3000 IU Advate (rAHF-PFM) (Using One 3000 IU Potency Vial) With 3000 IU Advate (rAHF PFM) (Using Two 1500 IU Potency Vials) in Previously Treated Patients With Severe Hemophilia A: a Phase 4, Open-label, Prospective, Randomized, Controlled, Crossover, Multiple Center Study Completed NCT00916032 Phase 4
18 Pharmacokinetic Comparison of Advate rAHF-PFM With Recombinate rAHF in Patients With Severe Hemophilia A: a Phase IV, Prospective, Randomized, Controlled, Cross-over, Single Center Study Completed NCT00666406 Phase 4 Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM);Recombinant Factor VIII (rAHF)
19 A Diagnostic Interventional, Controlled, Cross-sectional Evaluation of Joint Status Using Magnetic Resonance Imaging in Subjects With Severe Hemophilia A Treated With Primary Prophylaxis, Secondary Prophylaxis, or On-demand Therapy Completed NCT00927667 Phase 4
20 Combination Therapy of Low Doses of rFVIIa and FEIBA for Severe Hemophilia A Patients With an Inhibitor to Factor VIII Completed NCT00284193 Phase 4 rFVIIa-FEIBA therapy for hemophilia A inhibitors;FEIBA- Activated Prothrombin Complexes
21 Advate Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (ADVATE rAHF-PFM): A Phase 4 Study to Determine the Pharmacokinetic Response of Patients Diagnosed With Severe Hemophilia A to Different Doses of ADVATE rAHF-PFM Completed NCT00289536 Phase 4
22 Routine Prophylaxis Treatment Versus On-demand Treatment for Children With Severe Hemophilia A: Comparison of All Bleeding Events in Chinese Hemophilia Patients Completed NCT01810666 Phase 4
23 A Non-controlled, Open-Label, Multicenter, Study of Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Subjects With Inhibitors Undergoing the First ITI Treatment Completed NCT03093480 Phase 4
24 Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy Completed NCT00638001 Phase 4
25 Efficacy and Cost Effectiveness of Standard Versus Pharmacokinetic Dosing During Factor VIII Prophylaxis in Adult Patients With Severe Haemophilia A Completed NCT02697370 Phase 4 Pharmacokinetic based dosage change
26 A Prospective Controlled Study on the Effect on Bleeding Events and Joint Function in Young Adults With Severe Hemophilia A After a 6 Month Prophylaxis Treatment Compared to on Demand Treatment Completed NCT00586521 Phase 4 Kogenate (BAY14-2222)
27 A Non-Controlled, Open-Label, Multicenter, Study of Immune Tolerance Induction Performed With rFVIIIFc Within a Timeframe of 60 Weeks in Severe Haemophilia A Patients With Inhibitors Who Have Failed Previous Immune Tolerance Induction Therapies Completed NCT03103542 Phase 4
28 Safety of Turoctocog Alfa for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Patients With Moderate or Severe Haemophilia A in India Completed NCT03449342 Phase 4 turoctocog alfa
29 rFVIIa (NovoSeven®) for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors: A Double-blind Study of a Single High Dose Versus Standard Multiple Doses of rFVIIa Completed NCT00571584 Phase 4 activated recombinant human factor VII
30 Post Marketing Study in Haemophilia B Patients Using Nonafact® 100 IU/ml Powder and Solvent for Solution for Injection(Human Coagulation Factor IX)(Human Plasma Derived Factor IX Product, Freeze Dried) Completed NCT00139828 Phase 4 human coagulation Factor IX
31 NovoSeven® (rFVIIa) by Single Dose for Home Treatment of Joint Bleeds in Haemophilia Patients With Inhibitors: A Pilot, Double-Blind Study Versus Standard Multiple Doses of NovoSeven® and Open-Label FEIBA® Completed NCT00108797 Phase 4 eptacog alfa (activated);Feiba VH
32 A Prospective Study to Evaluate the Effect of rFVIII-FS in Different Prophylactic Regimens on Bleeding Events Frequency and Development of Arthropathy in Previously Treated and Minimally Treated Hemophilia A Pediatric Population. Completed NCT00632814 Phase 4 rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week;rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg);rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
34 An Open-label, Single-arm, Post- Authorization Pragmatic Clinical Trial On The Safety And Efficacy Of Xyntha (Moroctocog-alfa (Af-cc), Recombinant Fviii) In Subjects With Hemophilia A In Usual Care Settings In China Completed NCT02492984 Phase 4 Intravenous infusions of Xyntha
35 Inhibitor Development in Previously Untreated Patients (PUPs) or Minimally Blood Component-Treated Patients (MBCTPs) When Exposed to Plasma-derived Von Willebrand Factor-Containing Factor VIII (VWF/FVIII) Concentrates and to Recombinant Factor VIII (rFVIII) Concentrates: An Independent, International, Multicentre, Prospective, Controlled, Randomised, Open Label, Clinical Trial Completed NCT01064284 Phase 4 PLASMA DERIVED Factor VIII;Recombinant FVIII
36 A Phase IV Study of the Safety and Efficacy of ReFacto® (Moroctocog Alfa, B-Domain Deleted Recombinant Factor VIII) in Subjects With Hemophilia A Undergoing Major Surgery Monitored Using the Chromogenic Substrate Assay at the Local Laboratory Completed NCT00092976 Phase 4 ReFacto
37 Study to Evaluate Efficacy and Safety of ADVATE in the Treatment of Previously Treated Patients With Hemophilia A Completed NCT02170402 Phase 4
38 A Study on PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin) in Iranian Hemophilic Patients With Chronic Hepatitis C Infection Completed NCT00707772 Phase 4 PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin);PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)
39 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
40 IMMUNINE - Purified Factor IX Concentrate Virus-Inactivated: A Phase 4, Prospective, Open-label Multicenter Study to Prospectively Document the Exposure of IMMUNINE and to Monitor FIX Inhibitors in Previously Treated Patients With Severe (FIX Level < 1%) or Moderately Severe (FIX Level <= 2%) Hemophilia B Who Are Planned to Enter BAX 326 Study 250901 to Investigate a New Recombinant FIX Concentrate Completed NCT01128881 Phase 4
41 Reformulated BeneFIX Efficacy and Safety After Conversion From a pdFIX Completed NCT00749476 Phase 4
42 Evaluation of Efficacy and Safety of Benefix®- Coagulation Factor ix, Recombinant, in Previously Treated Patients With Hemophilia b. Completed NCT00581126 Phase 4 Recombinant Factor IX Coagulation
43 An Open-label, Single-arm, Post-authorization Pragmatic Clinical Trial On The Safety And Efficacy Of Benefix (Nonacog Alfa, Recombinant Factor Ix) In Subjects With Hemophilia B In Usual Care Settings In China Completed NCT02336178 Phase 4 Benefix
44 A Multiclinic, Open Pilot Study to Investigate the Effect of Combination Antiretroviral Therapy Including Indinavir Sulfate on Coagulation Factors, on Platelet Aggregation, and on Factor VIII/IX Half-Life in HIV-1 Seropositive Patients With Hemophilia A or B Completed NCT00002386 Phase 4 Indinavir sulfate;Lamivudine;Stavudine;Zidovudine;Zalcitabine;Didanosine
45 Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex (Humate-P®) Using Individualized Dosing in Pediatric and Adult Surgical Subjects With Von Willebrand's Disease. Completed NCT00168090 Phase 4 Blood coagulation Factor VIII and vWF, human
46 A Randomized Controlled Trial of the Effect of Cytochrome P450 2C19 Genotype-Specific Dosing Plus TDM vs. TDM Alone on Reaching Therapeutic Voriconazole Blood Levels Completed NCT03731169 Phase 4 Standard of Care
47 An Open Label Study to Evaluate the Safety and Effect on Sustained Virological Response of PEGASYS Plus Ribavirin in Patients With Hemophilia A and Chronic Hepatitis C Completed NCT00475072 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin
48 A Post Approval Commitment Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of KOVALTRY in Chinese Children, Adolescents /Adults With Severe Hemophilia A Recruiting NCT04565236 Phase 4
49 The Effectiveness of Recombinant Fusion Protein Linking Coagulation Factor IX With Recombinant Albumin (rIX-FP) in Severe Hemophilia B Patients Switching From Previous Factor IX Treatment Recruiting NCT04108260 Phase 4 Albutrepenonacog Alfa 1 UNT [IDELVION]
50 A Multicenter, Open, Extension Trial to Evaluate Safety and Efficacy of Recombinant Human Coagulation Factor VIII (SCT800) During Long Term Treatment in Previously Treated Patients With Severe Haemophilia A . Recruiting NCT03947567 Phase 4 Recombinant Human Coagulation FVIII

Search NIH Clinical Center for Hemophilia a

Inferred drug relations via UMLS 70 / NDF-RT 51 :

antihemophilic factor, human
Antihemophilic Factor, Human Recombinant
Antihemophilic factor, porcine
Factor VIII
nonacog alfa
recombinant FVIIa

Genetic Tests for Hemophilia a

Anatomical Context for Hemophilia a

MalaCards organs/tissues related to Hemophilia a:

Bone, Liver, Heart, Endothelial, Kidney, T Cells, Lung

Publications for Hemophilia a

Articles related to Hemophilia a:

(show top 50) (show all 5541)
# Title Authors PMID Year
Inhibitors of factor VIII in black patients with hemophilia. 25 6 57 61
19369668 2009
Somatic mosaicism in hemophilia A: a fairly common event. 61 6 57 25
11410838 2001
Molecular and phenotypic determinants of the response to desmopressin in adult patients with mild hemophilia A. 61 54 25 6
19719828 2009
Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction of hemophilia A patients with high-responding inhibitors. 61 54 6 25
19740093 2009
Identification of 217 unreported mutations in the F8 gene in a group of 1,410 unselected Italian patients with hemophilia A. 61 6 57
18217193 2008
Detection of 95 novel mutations in coagulation factor VIII gene F8 responsible for hemophilia A: results from a single institution. 61 6 57
16786531 2006
Factor VIII deficiency not induced by FVIII gene mutation in a female first cousin of two brothers with haemophilia A. 61 57 6
12406074 2002
The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion. 61 57 6
12242334 2002
Skewed X-chromosome inactivation in monochorionic diamniotic twin sisters results in severe and mild hemophilia A. 61 57 6
12351418 2002
The identification and classification of 41 novel mutations in the factor VIII gene (F8C). 61 57 6
11857744 2002
An Alu insert as the cause of a severe form of hemophilia A. 6 57 61
11713379 2001
De novo factor VIII gene intron 22 inversion in a female carrier presents as a somatic mosaicism. 61 6 57
11023529 2000
Characterization of the factor VIII defect in 147 patients with sporadic hemophilia A: family studies indicate a mutation type-dependent sex ratio of mutation frequencies. 61 6 57
8644728 1996
Factor VIII gene inversions in severe hemophilia A: results of an international consortium study. 61 6 57
7662970 1995
Molecular etiology of factor VIII deficiency in hemophilia A. 61 57 6
7728145 1995
Three missense mutations in Arg codons of the factor VIII genes of mild to moderately severe hemophilia A patients. 61 6 57
1412186 1992
A directed search for mutations in hemophilia A using restriction enzyme analysis and denaturing gradient gel electrophoresis. A study of seven exons in the factor VIII gene of 170 cases. 61 57 6
1523102 1992
Mutations and a polymorphism in the factor VIII gene discovered by denaturing gradient gel electrophoresis. 61 6 57
2107542 1990
Molecular analysis of hemophilia A mutations in the Finnish population. 57 6 61
2104741 1990
Nonsense and missense mutations in hemophilia A: estimate of the relative mutation rate at CG dinucleotides. 61 57 6
2833855 1988
Characterization of five partial deletions of the factor VIII gene. 57 6 61
3035554 1987
Hemophilia A. Detection of molecular defects and of carriers by DNA analysis. 61 6 57
2993888 1985
Novel approach to genetic analysis and results in 3000 hemophilia patients enrolled in the My Life, Our Future initiative. 6 25 61
29296726 2017
Molecular mechanisms underlying hemophilia A phenotype in seven females. 25 6 61
19302446 2009
Haemophilia A mutations in the UK: results of screening one-third of the population. 57 6
18691168 2008
Bleeding in carriers of hemophilia. 57 25 61
16551972 2006
Familial nonrandom inactivation linked to the X inactivation centre in heterozygotes manifesting haemophilia A. 6 57
15741993 2005
Characteristic mRNA abnormality found in half the patients with severe haemophilia A is due to large DNA inversions. 6 57
8281136 1993
Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A. 6 57
8275087 1993
Analysis of factor VIII mRNA reveals defects in everyone of 28 haemophilia A patients. 6 57
8490618 1993
Factor VIII gene explains all cases of haemophilia A. 57 6
1357455 1992
Factor VIII gene deletions in haemophilia A patients in Czechoslovakia. 6 57
1643024 1992
Detection of three novel mutations in two haemophilia A patients by rapid screening of whole essential region of factor VIII gene. 57 6
1671991 1991
A transcribed gene in an intron of the human factor VIII gene. 57 6
2110545 1990
A recurrent missense mutation (Arg----Gln) and a partial deletion in factor VIII gene causing severe haemophilia A. 57 6
2493803 1989
Maternal duplication associated with gene deletion in sporadic hemophilia. 57 6
2901224 1988
Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man. 6 57
2831458 1988
A somatic mosaic for haemophilia A detected at the DNA level. 6 57
3131627 1988
A novel missense mutation in the factor VIII gene identified by analysis of amplified hemophilia DNA sequences. 6 57
3122181 1987
Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots. 6 57
3097553 1986
Detection and sequence of mutations in the factor VIII gene of haemophiliacs. 6 57
2987704 1985
Genetic mapping and diagnosis of haemophilia A achieved through a BclI polymorphism in the factor VIII gene. 57 6
2986011 1985
Hemophilia in the female dog. 57 6
15431070 1950
Factor 8 (F8) gene mutation profile of Turkish hemophilia A patients with inhibitors. 61 54 6
18600086 2008
The Italian AICE-Genetics hemophilia A database: results and correlation with clinical phenotype. 6 54 61
18387975 2008
Factor VIII (FVIII) gene mutations in 120 patients with hemophilia A: detection of 26 novel mutations and correlation with FVIII inhibitor development. 6 61 54
17445092 2007
F8 gene mutation profile and ITT response in a cohort of Italian haemophilia A patients with inhibitors. 25 6
17610549 2007
Spectrum of molecular defects and mutation detection rate in patients with mild and moderate hemophilia A. 61 54 6
16972227 2007
Sequencing of the factor 8(F8) coding regions in 10 Turkish hemophilia A patients reveals three novel pathological mutations, and one rediagnosis of von Willebrand's disease type 2N. 61 6 54
16834740 2006
Aminoglycoside suppression of nonsense mutations in severe hemophilia. 57 54 61
16051741 2005

Variations for Hemophilia a

ClinVar genetic disease variations for Hemophilia a:

6 (show top 50) (show all 474)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 F8 NM_000132.3(F8):c.6976C>T (p.Arg2326Ter) SNV Pathogenic 10085 rs137852354 GRCh37: X:154065952-154065952
GRCh38: X:154837677-154837677
2 F8 NM_000132.3(F8):c.6682C>T (p.Arg2228Ter) SNV Pathogenic 10086 rs137852355 GRCh37: X:154090034-154090034
GRCh38: X:154861759-154861759
3 F8 F8, EX26DEL Deletion Pathogenic 10087 GRCh37:
4 F8 NM_000132.3(F8):c.6403C>T (p.Arg2135Ter) SNV Pathogenic 10088 rs137852356 GRCh37: X:154124378-154124378
GRCh38: X:154896103-154896103
5 F8 F8, EX6DEL Deletion Pathogenic 10089 GRCh37:
6 F8 F8, EX14DEL Deletion Pathogenic 10090 GRCh37:
7 F8 F8, EX24-25DEL Deletion Pathogenic 10091 GRCh37:
8 F8 F8, EX23-25DEL Deletion Pathogenic 10092 GRCh37:
9 F8 F8, EX22DEL Deletion Pathogenic 10093 GRCh37:
10 F8 F8, EX26DEL Deletion Pathogenic 10094 GRCh37:
11 F8 F8, EX1DEL Deletion Pathogenic 10095 GRCh37:
12 F8 NM_000132.3(F8):c.6496C>T (p.Arg2166Ter) SNV Pathogenic 10096 rs137852357 GRCh37: X:154091436-154091436
GRCh38: X:154863161-154863161
13 F8 NM_000132.3(F8):c.601+1632G>A SNV Pathogenic 10097 rs387906429 GRCh37: X:154219579-154219579
GRCh38: X:154991304-154991304
14 F8 NM_000132.3(F8):c.6683G>A (p.Arg2228Gln) SNV Pathogenic 10098 rs137852358 GRCh37: X:154090033-154090033
GRCh38: X:154861758-154861758
15 F8 NM_000132.3(F8):c.872A>G (p.Glu291Gly) SNV Pathogenic 10099 rs137852359 GRCh37: X:154197743-154197743
GRCh38: X:154969468-154969468
16 F8 F8, EX2-3DEL Deletion Pathogenic 10100 GRCh37:
17 F8 F8, EX3-13DEL Deletion Pathogenic 10101 GRCh37:
18 F8 F8, EX4-25DEL Deletion Pathogenic 10102 GRCh37:
19 F8 F8, EX7-14DEL Deletion Pathogenic 10103 GRCh37:
20 F8 F8, EX26DEL Deletion Pathogenic 10105 GRCh37:
21 F8 F8, LINE INS, EX14 Insertion Pathogenic 10106 GRCh37:
22 F8 F8, EX15DEL Deletion Pathogenic 10107 GRCh37:
23 F8 F8, 2-BP DEL, EX8 Deletion Pathogenic 10108 GRCh37:
24 F8 NM_000132.3(F8):c.6977G>T (p.Arg2326Leu) SNV Pathogenic 10109 rs137852360 GRCh37: X:154065951-154065951
GRCh38: X:154837676-154837676
25 F8 NM_000132.3(F8):c.5879G>A (p.Arg1960Gln) SNV Pathogenic 10110 rs28937294 GRCh37: X:154132300-154132300
GRCh38: X:154904025-154904025
26 F8 NM_000132.3(F8):c.5113C>T (p.Gln1705Ter) SNV Pathogenic 10112 rs137852361 GRCh37: X:154156952-154156952
GRCh38: X:154928677-154928677
27 F8 F8, EX14DEL Deletion Pathogenic 10113 GRCh37:
28 F8 NM_000132.3(F8):c.5096A>T (p.Tyr1699Phe) SNV Pathogenic 10115 rs28935203 GRCh37: X:154156969-154156969
GRCh38: X:154928694-154928694
29 F8 NM_000132.3(F8):c.5183A>G (p.Tyr1728Cys) SNV Pathogenic 10116 rs137852362 GRCh37: X:154156882-154156882
GRCh38: X:154928607-154928607
30 F8 F8, EX11-18DEL Deletion Pathogenic 10117 GRCh37:
31 F8 NM_000132.3(F8):c.5878C>T (p.Arg1960Ter) SNV Pathogenic 10118 rs137852363 GRCh37: X:154132301-154132301
GRCh38: X:154904026-154904026
32 F8 F8, EX3DEL Deletion Pathogenic 10119 GRCh37:
33 F8 F8, EX1-5DEL Deletion Pathogenic 10121 GRCh37:
34 F8 F8, EX1-22DEL Deletion Pathogenic 10122 GRCh37:
35 F8 F8, EX26DEL Deletion Pathogenic 10123 GRCh37:
36 F8 F8, EX1-26DEL Deletion Pathogenic 10124 GRCh37:
37 F8 NM_000132.3(F8):c.1171C>T (p.Arg391Cys) SNV Pathogenic 10125 rs137852364 GRCh37: X:154194801-154194801
GRCh38: X:154966526-154966526
38 F8 NM_000132.3(F8):c.6977G>A (p.Arg2326Gln) SNV Pathogenic 10126 rs137852360 GRCh37: X:154065951-154065951
GRCh38: X:154837676-154837676
39 F8 NM_000132.3(F8):c.6554T>C (p.Leu2185Ser) SNV Pathogenic 10127 rs137852365 GRCh37: X:154091378-154091378
GRCh38: X:154863103-154863103
40 F8 NM_000132.3(F8):c.6404G>C (p.Arg2135Pro) SNV Pathogenic 10128 rs137852366 GRCh37: X:154124377-154124377
GRCh38: X:154896102-154896102
41 F8 NM_000132.3(F8):c.566C>T (p.Ser189Leu) SNV Pathogenic 10129 rs137852367 GRCh37: X:154221246-154221246
GRCh38: X:154992971-154992971
42 F8 F8, EX15-18DEL Deletion Pathogenic 10130 GRCh37:
43 F8 NM_000132.3(F8):c.2114-?_5219+?del (p.?) Deletion Pathogenic 10131 GRCh37: X:154134848-154175973
GRCh38: X:154906573-154947698
44 F8 F8, EX23-25DEL Deletion Pathogenic 10132 GRCh37:
45 F8 F8, EX14DEL Deletion Pathogenic 10133 GRCh37:
46 F8 F8, EX7-9DEL Deletion Pathogenic 10134 GRCh37:
47 F8 F8, EX5DEL Deletion Pathogenic 10135 GRCh37:
48 F8 F8, EX5DEL Deletion Pathogenic 10136 GRCh37:
49 F8 F8, EX5DEL Deletion Pathogenic 10137 GRCh37:
50 F8 F8, EX5-6 DEL Deletion Pathogenic 10138 GRCh37:

UniProtKB/Swiss-Prot genetic disease variations for Hemophilia a:

72 (show top 50) (show all 472)
# Symbol AA change Variation ID SNP ID
1 F8 p.Leu26Arg VAR_001045 rs137852377
2 F8 p.Glu30Val VAR_001046 rs137852378
3 F8 p.Gly41Cys VAR_001047 rs137852379
4 F8 p.Arg48Cys VAR_001048
5 F8 p.Gly89Asp VAR_001050 rs137852380
6 F8 p.Gly89Val VAR_001051
7 F8 p.Val99Asp VAR_001052 rs137852382
8 F8 p.Val104Asp VAR_001053 rs137852383
9 F8 p.Lys108Thr VAR_001054 rs137852384
10 F8 p.Met110Val VAR_001055 rs137852385
11 F8 p.Leu117Arg VAR_001056 rs137852386
12 F8 p.Glu129Val VAR_001057
13 F8 p.Gly130Arg VAR_001058 rs137852387
14 F8 p.Glu132Asp VAR_001059 rs137852388
15 F8 p.Tyr133Cys VAR_001060 rs137852389
16 F8 p.Asp135Gly VAR_001061 rs137852390
17 F8 p.Thr137Ile VAR_001062 rs137852391
18 F8 p.Gly164Val VAR_001063 rs137852392
19 F8 p.Pro165Ser VAR_001064 rs137852393
20 F8 p.Val181Met VAR_001065 rs137852394
21 F8 p.Lys185Thr VAR_001066 rs137852395
22 F8 p.Ser189Leu VAR_001067 rs137852367
23 F8 p.Asp222Val VAR_001068 rs137852396
24 F8 p.Gly224Trp VAR_001069 rs137852397
25 F8 p.Val253Phe VAR_001070
26 F8 p.Gly266Glu VAR_001071 rs137852398
27 F8 p.Gly278Arg VAR_001072 rs137852399
28 F8 p.Val285Gly VAR_001073 rs137852400
29 F8 p.Glu291Gly VAR_001074 rs137852359
30 F8 p.Thr294Ile VAR_001075 rs137852401
31 F8 p.Asn299Ile VAR_001076 rs137852402
32 F8 p.Arg301His VAR_001077 rs137852403
33 F8 p.Arg301Leu VAR_001078 rs137852403
34 F8 p.Ser308Leu VAR_001079 rs137852404
35 F8 p.Phe312Ser VAR_001080 rs137852405
36 F8 p.Thr314Ala VAR_001081 rs137852406
37 F8 p.Thr314Ile VAR_001082
38 F8 p.Leu327Pro VAR_001083 rs137852407
39 F8 p.Ile331Val VAR_001084
40 F8 p.Val345Leu VAR_001085 rs137852371
41 F8 p.Cys348Arg VAR_001086 rs137852370
42 F8 p.Cys348Ser VAR_001087 rs137852410
43 F8 p.Cys348Tyr VAR_001088
44 F8 p.Arg391Cys VAR_001089 rs137852364
45 F8 p.Arg391His VAR_001090 rs28935499
46 F8 p.Arg391Pro VAR_001091
47 F8 p.Ser392Leu VAR_001092 rs28933668
48 F8 p.Ser392Pro VAR_001093 rs28933669
49 F8 p.Ile405Ser VAR_001094 rs28933670
50 F8 p.Glu409Gly VAR_001095 rs28933671

Copy number variations for Hemophilia a from CNVD:

# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 260219 X 146900000 154913754 Deletion F8 Hemophilia A
2 260222 X 146900000 154913754 Deletion MPP1 Hemophilia A
3 260242 X 146900000 154913754 Inversion F8 Hemophilia A

Expression for Hemophilia a

Search GEO for disease gene expression data for Hemophilia a.

Pathways for Hemophilia a

GO Terms for Hemophilia a

Cellular components related to Hemophilia a according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 VWF F9 F8 F7 F5 F3
2 collagen-containing extracellular matrix GO:0062023 9.62 VWF F9 F7 F3
3 endoplasmic reticulum lumen GO:0005788 9.46 F9 F8 F7 F5
4 COPII-coated ER to Golgi transport vesicle GO:0030134 9.4 F8 F5
5 platelet alpha granule GO:0031091 9.26 VWF F5
6 platelet alpha granule lumen GO:0031093 9.13 VWF F8 F5
7 serine-type peptidase complex GO:1905286 8.62 F7 F3

Biological processes related to Hemophilia a according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.67 F9 F8 F7 F5
2 platelet degranulation GO:0002576 9.61 VWF F8 F5
3 blood coagulation GO:0007596 9.43 VWF F9 F8 F7 F5 F3
4 positive regulation of positive chemotaxis GO:0050927 9.4 F7 F3
5 blood coagulation, intrinsic pathway GO:0007597 9.33 VWF F9 F8
6 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.32 F7 F3
7 blood coagulation, extrinsic pathway GO:0007598 9.26 F7 F3
8 hemostasis GO:0007599 9.1 VWF F9 F8 F7 F5 F3

Molecular functions related to Hemophilia a according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F9 F7 F3

Sources for Hemophilia a

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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