MCID: HMP018
MIFTS: 39

Hemophilic Arthropathy

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hemophilic Arthropathy

MalaCards integrated aliases for Hemophilic Arthropathy:

Name: Hemophilic Arthropathy 53 73

Classifications:



External Ids:

UMLS 73 C0263725

Summaries for Hemophilic Arthropathy

MalaCards based summary : Hemophilic Arthropathy is related to arthropathy and osteoporosis. An important gene associated with Hemophilic Arthropathy is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Endothelin-1/EDNRA signaling. The drugs Hyaluronic acid and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are growth/size/body region and behavior/neurological

Wikipedia : 76 Haemophilia is a mostly inherited genetic disorder that impairs the body''s ability to make blood clots,... more...

Related Diseases for Hemophilic Arthropathy

Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 arthropathy 31.3 COMP HFE TNFRSF11B TNFSF11
2 osteoporosis 29.9 TNFRSF11A TNFRSF11B TNFSF11
3 synovitis 29.9 COMP TNFRSF11B TNFSF11
4 bone resorption disease 29.8 TNFRSF11A TNFRSF11B TNFSF11
5 arthritis 29.6 PTGS2 TNFRSF11A TNFSF11
6 joint disorders 10.5
7 hemophilia 10.3
8 osteoarthritis 10.2
9 periodontitis 10.1 TNFRSF11B TNFSF11
10 osteoid osteoma 10.0
11 hemophilia a 10.0
12 leukemia 10.0
13 von willebrand's disease 10.0
14 poliomyelitis 10.0
15 human immunodeficiency virus infectious disease 10.0
16 hemarthrosis 10.0
17 septic arthritis 10.0
18 depression 10.0
19 multicentric reticulohistiocytosis 10.0 TNFRSF11B TNFSF11
20 kummell's disease 10.0 TNFRSF11B TNFSF11
21 periodontitis, chronic 10.0 TNFRSF11B TNFSF11
22 chronic apical periodontitis 10.0 TNFRSF11B TNFSF11
23 chondrocalcinosis 10.0 HFE TNFRSF11B
24 breast leiomyosarcoma 10.0 TNFRSF11A TNFSF11
25 glucocorticoid-induced osteoporosis 10.0 TNFRSF11B TNFSF11
26 osteopetrosis, autosomal recessive 7 10.0 TNFRSF11A TNFSF11
27 osteopetrosis 10.0 TNFRSF11A TNFSF11
28 osteopetrosis, autosomal recessive 2 10.0 TNFRSF11A TNFSF11
29 aneurysmal bone cysts 10.0 TNFRSF11A TNFSF11
30 endosteal hyperostosis, autosomal dominant 10.0 TNFRSF11B TNFSF11
31 osteonecrosis 9.9 TNFRSF11B TNFSF11
32 aortic valve disease 2 9.9 TNFRSF11B TNFSF11
33 chondroblastoma 9.9 PTGS2 TNFSF11
34 psoriatic arthritis 9.9 COMP TNFRSF11B TNFSF11
35 bone cancer 9.9 TNFRSF11A TNFSF11
36 keratocystic odontogenic tumor 9.9 PTGS2 TNFSF11
37 polyarticular onset juvenile idiopathic arthritis 9.8 TNFRSF11A TNFRSF11B TNFSF11
38 paget disease of bone 5, juvenile-onset 9.8 TNFRSF11A TNFRSF11B TNFSF11
39 familial expansile osteolysis 9.8 TNFRSF11A TNFRSF11B TNFSF11
40 multicentric carpotarsal osteolysis syndrome 9.8 TNFRSF11A TNFRSF11B TNFSF11
41 periapical periodontitis 9.8 TNFRSF11A TNFRSF11B TNFSF11
42 tooth resorption 9.8 TNFRSF11A TNFRSF11B TNFSF11
43 ischemic bone disease 9.8 TNFRSF11A TNFRSF11B TNFSF11
44 bone disease 9.8 TNFRSF11A TNFRSF11B TNFSF11
45 beta-thalassemia 9.8 HFE TNFRSF11B
46 root resorption 9.8 TNFRSF11A TNFRSF11B TNFSF11
47 bone remodeling disease 9.8 TNFRSF11A TNFRSF11B TNFSF11
48 giant cell tumor 9.8 TNFRSF11A TNFRSF11B TNFSF11
49 paget's disease of bone 9.8 TNFRSF11A TNFRSF11B TNFSF11
50 periodontal disease 9.8 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to Hemophilic Arthropathy

Symptoms & Phenotypes for Hemophilic Arthropathy

MGI Mouse Phenotypes related to Hemophilic Arthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
2 behavior/neurological MP:0005386 9.83 COMP HFE PTGS2 TNFRSF11A TNFSF11
3 cellular MP:0005384 9.8 COMP HFE PTGS2 TNFRSF11A TNFRSF11B
4 immune system MP:0005387 9.73 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
5 hematopoietic system MP:0005397 9.72 HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
6 limbs/digits/tail MP:0005371 9.55 COMP HFE TNFRSF11A TNFRSF11B TNFSF11
7 no phenotypic analysis MP:0003012 9.26 HFE PTGS2 TNFRSF11A TNFSF11
8 skeleton MP:0005390 9.1 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Hemophilic Arthropathy

Drugs for Hemophilic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
4 Factor VIII Phase 4,Not Applicable
5 triamcinolone acetonide Phase 4
6 Immunologic Factors Phase 4,Not Applicable
7 Hylan Phase 4
8 Triamcinolone diacetate Phase 4
9 Viscosupplements Phase 4,Not Applicable
10 Triamcinolone hexacetonide Phase 4
11 Protective Agents Phase 4,Not Applicable
12 Adjuvants, Immunologic Phase 4,Not Applicable
13
Thrombin Approved, Investigational Not Applicable
14 Soy Bean Not Applicable
15 Coagulants ,Not Applicable
16 Fluorodeoxyglucose F18 Not Applicable
17 Fluorides Not Applicable
18 Hemostatics Not Applicable
19 Complement System Proteins

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
2 A Proof-of-Concept Study of AC-201 Controlled-Release Tablet (CR Tablet) in Patients With Hemophilic Arthropathy Recruiting NCT02994147 Phase 2 Placebo;AC-201CR
3 Myofascial Therapy in Patients With Hemophilic Arthropathy Unknown status NCT02433782 Not Applicable
4 Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy Unknown status NCT02569359 Not Applicable
5 Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia Unknown status NCT02165592
6 Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A Patients Unknown status NCT02622646 Recombinant VIII factor
7 Effectiveness of the Myofascial Therapy in the Hemophilic Arthropathy of Ankle Completed NCT02825667 Not Applicable
8 Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy Completed NCT02601170 Not Applicable Hyaluronic Acid Viscosupplementation
9 Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles Completed NCT01232634
10 Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy Completed NCT02165462
11 Physiotherapy in the Haemophilic Arthropathy of the Elbow. Completed NCT02198040 Not Applicable
12 Manual Therapy in Haemophilic Arthropathy of the Knee Completed NCT02198014 Not Applicable
13 Gait Evaluation in Haemophiliac Patients Completed NCT00824798
14 Exploratory Pilot Study of Physical Activity Monitoring in Adult Patients With Haemophilia A by Means of Accelerometry Completed NCT02253693
15 Educational Physiotherapy in Haemophilia Completed NCT02825706 Not Applicable
16 PET Imaging of Hemophilic Arthropathy Recruiting NCT03485170 Not Applicable
17 Fascial Therapy in Elbow Hemophilic Arthropathy Recruiting NCT03009591 Not Applicable
18 TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia Recruiting NCT02781766 Not Applicable
19 Joint Outcome Study Continuation for Children With Severe Factor VIII Deficiency Enrolling by invitation NCT01000844
20 Pain in Patients With Congenital Coagulopathies Not yet recruiting NCT03499522
21 Osteoporosis and MRI Study in Hemophilia Terminated NCT01460147 Not Applicable

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

Anatomical Context for Hemophilic Arthropathy

MalaCards organs/tissues related to Hemophilic Arthropathy:

41
Brain, Bone, Testes

Publications for Hemophilic Arthropathy

Articles related to Hemophilic Arthropathy:

(show top 50) (show all 165)
# Title Authors Year
1
Range of motion after total knee arthroplasty in hemophilic arthropathy. ( 29788949 )
2018
2
Advanced Hemophilic Arthropathy: Sensitivity of Soft Tissue Discrimination With Musculoskeletal Ultrasound. ( 29363781 )
2018
3
Synovectomy using Samarium-153 Hydroxyapatite in the Elbows and Ankles of Patients with Hemophilic Arthropathy. ( 29398959 )
2018
4
Safety and effectiveness of fascial therapy in adult patients with hemophilic arthropathy. A pilot study. ( 29334292 )
2018
5
Joint lavage followed by intra-articular injection of hyaluronic acid and/or corticosteroids in patients with severe hemophilic arthropathy of the knee: Is this intervention really effective? ( 29722575 )
2018
6
Clinical and Radiological Evaluation After Chemical Synovectomy With Rifampicin in Hemophilic Arthropathy: Korean Experience With a 2-Week Interval Protocol. ( 29961743 )
2018
7
Safety of fascial therapy in adult patients with hemophilic arthropathy of ankle. A cohort study. ( 29550698 )
2018
8
Missing angiogenic factors in hemophilic arthropathy. ( 29103337 )
2018
9
Simultaneous bilateral total knee arthroplasty in patients with end-stage hemophilic arthropathy: a mean follow-up of 6 years. ( 29371670 )
2018
10
Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNFI+ pathway. ( 29776906 )
2018
11
Response to: missing angiogenic factors in hemophilic arthropathy. ( 29092644 )
2018
12
Hemophilic arthropathy in a patient with multi-joint replacement: A case report and literature review. ( 30024499 )
2018
13
Manual and educational therapy in the treatment of hemophilic arthropathy of the elbow: a randomized pilot study. ( 30176883 )
2018
14
Increased serum levels of progranulin (PGRN) in patients with hemophilic arthropathy. ( 30488982 )
2018
15
Management of Hemophilic Arthropathy of the Ankle. ( 28891453 )
2017
16
Ultrasound for Early Detection of Joint Disease in Patients with Hemophilic Arthropathy. ( 28758960 )
2017
17
Cytokines in the pathogenesis of hemophilic arthropathy. ( 29153709 )
2017
18
Pathophysiology of Hemophilic Arthropathy. ( 28672826 )
2017
19
A Combined Ultrasonographic and Conventional Radiographic Assessment of Hemophilic Arthropathy. ( 28824241 )
2017
20
Pathophysiology of hemophilic arthropathy and potential targets for therapy. ( 27890816 )
2017
21
Hemophilic Arthropathy. ( 28662249 )
2017
22
Synovium and cartilage biomarkers in hemophilic arthropathy. ( 26761216 )
2016
23
Intra-articular injections of mesenchymal stem cells (MSCs) as a treatment for hemophilic arthropathy. ( 27322636 )
2016
24
Assessment of Hemophilic Arthropathy by Ultrasound: Where Do We Stand? ( 27124619 )
2016
25
Advances and challenges in hemophilic arthropathy. ( 26805902 )
2016
26
Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy. ( 27861372 )
2016
27
Radiosynoviorthesis in hemophilic arthropathy: pathologic blood pool imaging on pre-therapeutic bone scintigraphy is not a predictor of treatment success. ( 27796541 )
2016
28
Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia. ( 27681457 )
2016
29
The F8(-/-) rat as a model of hemophilic arthropathy. ( 27060449 )
2016
30
Inflammation is key to hemophilic arthropathy. ( 26542253 )
2015
31
Diagnostic accuracy of ultrasound for assessment of hemophilic arthropathy: MRI correlation. ( 25714320 )
2015
32
Hemophilic arthropathy of the elbow: prophylaxis, imaging, and the role of invasiveA management. ( 26385390 )
2015
33
Total ankle replacement or ankle fusion in painful advanced hemophilic arthropathy of the ankle. ( 26358145 )
2015
34
Subjective results of joint lavage and viscosupplementation in hemophilic arthropathy. ( 26207096 )
2015
35
The long-term effects of radioactive phosphorous synoviorthesis on hemophilic arthropathy. ( 25976470 )
2015
36
Patient dissatisfaction after total knee arthroplasty for hemophilic arthropathy and osteoarthritis (non-hemophilia patients). ( 26561009 )
2015
37
Vascular remodeling underlies rebleeding in hemophilic arthropathy. ( 26257191 )
2015
38
Total Knee Arthroplasty in Hemophilic Arthropathy. ( 26665252 )
2015
39
Osteoid osteoma of the elbow mimicking hemophilic arthropathy. ( 24749122 )
2014
40
The Effectiveness of Tools for Monitoring Hemophilic Arthropathy. ( 25000469 )
2014
41
Manual therapy in the treatment of ankle hemophilic arthropathy. A randomized pilot study. ( 24678758 )
2014
42
Optimal management of hemophilic arthropathy and hematomas. ( 25378964 )
2014
43
Hemophilic arthropathy of shoulder joints: clinical, radiographic, and ultrasonographic characteristics of seventy patients. ( 23553306 )
2013
44
Hemophilic arthropathy: a review of imaging and staging. ( 24332203 )
2013
45
Outcome of Total Knee Arthroplasty in Hemophilic Arthropathy. ( 23958233 )
2013
46
Arthroscopic ankle arthrodesis in hemophilic arthropathy. ( 23478887 )
2013
47
Viscosupplementation in patients with hemophilic arthropathy. ( 24453636 )
2013
48
Osteoporosis/osteopenia and hemophilic arthropathy in severe hemophilic patients. ( 22292576 )
2012
49
Outcome of total knee arthroplasty combined patelloplasty for end-stage type A hemophilic arthropathy. ( 21342764 )
2012
50
Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factorA VIII-deficient mice. ( 22784361 )
2012

Variations for Hemophilic Arthropathy

Expression for Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for Hemophilic Arthropathy

Pathways related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 PTGS2 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.22 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.2 TNFRSF11A TNFRSF11B TNFSF11
4 12.12 PTGS2 TNFRSF11A TNFSF11
5
Show member pathways
11.85 PTGS2 TNFRSF11A TNFRSF11B TNFSF11
6 11.6 TNFRSF11A TNFRSF11B TNFSF11
7 11.48 TNFRSF11A TNFSF11
8 11.41 PTGS2 TNFRSF11A TNFSF11
9
Show member pathways
11.37 TNFRSF11A TNFSF11
10 10.88 TNFRSF11B TNFSF11
11 10.79 TNFRSF11A TNFRSF11B TNFSF11
12 10.51 TNFRSF11B TNFSF11
13 10 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Hemophilic Arthropathy

Cellular components related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 COMP HFE TNFRSF11B TNFSF11

Biological processes related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.54 COMP TNFSF11
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.52 TNFRSF11A TNFSF11
3 ossification GO:0001503 9.51 TNFRSF11A TNFSF11
4 response to cytokine GO:0034097 9.49 PTGS2 TNFRSF11A
5 monocyte chemotaxis GO:0002548 9.48 TNFRSF11A TNFSF11
6 response to radiation GO:0009314 9.46 PTGS2 TNFRSF11A
7 osteoclast differentiation GO:0030316 9.43 TNFRSF11A TNFSF11
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF11A TNFRSF11B TNFSF11
9 response to tumor necrosis factor GO:0034612 9.4 PTGS2 TNFRSF11A
10 positive regulation of bone resorption GO:0045780 9.37 TNFRSF11A TNFSF11
11 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
12 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
13 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFRSF11A TNFSF11
14 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.62 TNFRSF11A TNFSF11

Sources for Hemophilic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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