MCID: HMP018
MIFTS: 23

Hemophilic Arthropathy

Categories: Blood diseases, Rare diseases
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Aliases & Classifications for Hemophilic Arthropathy

MalaCards integrated aliases for Hemophilic Arthropathy:

Name: Hemophilic Arthropathy 19 75 71 75

Classifications:



External Ids:

UMLS 71 C0263725

Summaries for Hemophilic Arthropathy

GARD: 19 A form of arthritis that affects hemophiliacs, which is characterized by bleeding into the joint space.

MalaCards based summary: Hemophilic Arthropathy is related to arthropathy and osteoarthritis. The drugs Ropivacaine and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone.

Wikipedia: 75 Haemophilia, or hemophilia (from Ancient Greek αἷμα (haîma) 'blood', and φιλία (philía) 'love of'), is a... more...

Related Diseases for Hemophilic Arthropathy

Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 arthropathy 11.2
2 osteoarthritis 11.2
3 hemophilia 11.0
4 factor viii deficiency 10.8
5 hemarthrosis 10.8
6 hemophilia a 10.8
7 synovitis 10.7
8 hemophilia b 10.5
9 cartilage disease 10.3
10 von willebrand's disease 10.3
11 osteoporosis 10.2
12 bone mineral density quantitative trait locus 8 10.2
13 bone mineral density quantitative trait locus 15 10.2
14 ankylosis 10.2
15 chronic pain 10.2
16 immune deficiency disease 10.1
17 leukemia, acute lymphoblastic 3 10.1
18 bone resorption disease 10.1
19 b-lymphoblastic leukemia/lymphoma 10.1
20 vascular disease 10.1
21 osseous heteroplasia, progressive 10.0
22 polycystic liver disease 1 with or without kidney cysts 10.0
23 polykaryocytosis inducer 10.0
24 rheumatoid arthritis 10.0
25 thrombophilia due to thrombin defect 10.0
26 osteoid osteoma 10.0
27 rhabdomyosarcoma 2 10.0
28 thoracoabdominal syndrome 10.0
29 factor xi deficiency 10.0
30 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 10.0
31 bone disease 10.0
32 bicipital tenosynovitis 10.0
33 chondromalacia 10.0
34 poliomyelitis 10.0
35 hemolytic anemia 10.0
36 acquired immunodeficiency syndrome 10.0
37 compartment syndrome 10.0
38 osgood-schlatter's disease 10.0
39 muscular atrophy 10.0
40 septic arthritis 10.0
41 arthritis 10.0
42 tenosynovitis 10.0
43 prosthetic joint infection 10.0

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to Hemophilic Arthropathy

Symptoms & Phenotypes for Hemophilic Arthropathy

Drugs & Therapeutics for Hemophilic Arthropathy

Drugs for Hemophilic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4 Hylan Phase 4
5
Triamcinolone hexacetonide Phase 4
6
Triamcinolone diacetate Phase 4
7
Triamcinolone Acetonide Phase 4 6436
8
Rofecoxib Approved, Investigational, Withdrawn Phase 3 162011-90-7 5090
9 Cyclooxygenase Inhibitors Phase 3
10 Cyclooxygenase 2 Inhibitors Phase 3
11 Antirheumatic Agents Phase 3
12 Anti-Inflammatory Agents, Non-Steroidal Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Analgesics Phase 3
16
Cholecalciferol Approved, Nutraceutical, Vet_approved 67-97-0, 1406-16-2 5280795 10883523
17 Radiopharmaceuticals
18 Fluorodeoxyglucose F18
19 Fluorides
20 Adjuvants, Immunologic
21 Protective Agents
22 Viscosupplements
23 Immunologic Factors
24 Calciferol
25 Vitamins
26 Factor VIII
27 Soy Bean

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
2 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase III Study With a Long-Term, Open-Label Extension to Evaluate the Efficacy and Safety of TRM-201 (Rofecoxib) in Patients With Hemophilic Arthropathy Recruiting NCT04684511 Phase 3 TRM-201 (Rofecoxib);Placebo
3 A Proof-of-Concept Study of AC-201 Controlled-Release Tablet (CR Tablet) in Patients With Hemophilic Arthropathy Completed NCT02994147 Phase 2 Placebo;AC-201CR
4 Safety and Effectiveness of a Physiotherapy Intervention Through Movement Visualization in the Approach of Pain in Patients With Hemophilic Arthropathy. Multicenter Randomized Clinical Study. Unknown status NCT04237766
5 Physiotherapy Protocol by Myofascial Therapy and Randomized Clinical Study in Patients With Hemophilic Arthropathy Unknown status NCT02433782
6 PET Imaging of Hemophilic Arthropathy Correlates With Clinical, Radiographic and Sonographic Assessments Completed NCT03485170
7 External Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles. MRI Correlation. Completed NCT01232634
8 Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy Completed NCT02601170 Hyaluronic Acid Viscosupplementation
9 Randomized Clinical Study on the Effectiveness of the Myofascial Therapy in the Treatment of the Hemophilic Arthropathy of Ankle Completed NCT02825667
10 Investigation of Effectiveness of Manual Therapy and Strengthening Exercises in Physiotherapy and Rehabilitation of Hemophilic Arthropathy of the Elbow Completed NCT04308876
11 Physiotherapy in the Treatment of Elbow Hemophilic Arthropathy: Manual Therapy vs Educational Physiotherapy. A Pilot Sudy Completed NCT02198040
12 Effectiveness of Manual Therapy and Educational Physiotherapy in the Treatment of Hemophilic Arthropathy of the Knee. A Randomized Pilot Study Completed NCT02198014
13 Investigation of Effectiveness of Therapeutic Exercises on Target Joint Functions and Gait in Hemophilic Arthropathic Patients. Completed NCT04297696
14 Sarcopenia and Osteoporosis in the Patients With Hemophilia Completed NCT04535180
15 Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic Arthropathy Recruiting NCT05187936
16 Association of Vitamin D Deficiency, Sarcopenia, Body Composition, Osteoporosis and Hemophilic Arthropathy in the Patients With Hemophilia Recruiting NCT05517070
17 Efficacy of a Physiotherapy Intervention Through Movement Visualization in Pain Management in Patients With Hemophilic Arthropathy. Randomized Multicenter Clinical Study. Recruiting NCT04549402
18 Relationship of Pain and Joint Status With the Perception of Psychosocial Factors in Patients With Hemophilic Arthropathy: A Multicenter Observational Study Active, not recruiting NCT04715100
19 Effectiveness of Physiotherapy Intervention by Restricting Blood Flow in Improving Muscle Strength in Patients With Hemophilic Arthropathy. Randomized Multicenter Clinical Study. Not yet recruiting NCT05039008
20 Analysis of Clinical, Functional and Musculoskeletal Variables Between Adult Patients With Hemophilic Arthropathy of the Knee and Ankle and Their Healthy Peers. A Case-control Study Not yet recruiting NCT05589662
21 Safety and Efficacy of Manual Therapy in the Treatment of Hemophilic Arthropathy of the Ankle. A Pilot Study Not yet recruiting NCT05549843
22 Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy Terminated NCT02569359

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

Anatomical Context for Hemophilic Arthropathy

Organs/tissues related to Hemophilic Arthropathy:

MalaCards : Brain, Bone Marrow, Bone

Publications for Hemophilic Arthropathy

Articles related to Hemophilic Arthropathy:

(show top 50) (show all 493)
# Title Authors PMID Year
1
Joint status and related risk factors in patients with severe hemophilia A: a single-center cross-sectional study. 62
34964431 2022
2
[Study on the Therapeutic Effect of Lenalidomide on Hemophilic Arthropathy]. 62
36208264 2022
3
Hemophilia in the south of Tunisia. 62
35867935 2022
4
Clinical Evaluation of Balance in Children With Hemophilic Arthropathy. 62
36258722 2022
5
Exploring a potential role for selective COX-2 inhibitors for the prevention of hemophilic arthropathy. 62
36097142 2022
6
The potential role of protease systems in hemophilic arthropathy. 62
35580335 2022
7
The Correlation Between the HEAD-US-C Score and HJHS in Hemophilic Arthropathy of the Knee. 62
35920366 2022
8
Screening of behavioral disorders in children with hemophilia. 62
35635071 2022
9
Manual therapy reduces the frequency of clinical hemarthrosis and improves range of motion and perceived disability in patients with hemophilic elbow arthropathy. A randomized, single-blind, clinical trial. 62
33684015 2022
10
Perioperative blood loss during joint replacement: comparison between patients with and without hemophilia. 62
35729653 2022
11
Blocking hemophilic arthropathy. 62
35511191 2022
12
Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice. 62
35143636 2022
13
How much preoperative flexion contracture is a predictor for residual flexion contracture after total knee arthroplasty in hemophilic arthropathy and rheumatoid arthritis? 62
35395934 2022
14
Postoperative bleeding complications in patients with hemophilia undergoing major orthopedic surgery: A prospective multicenter observational study. 62
35080347 2022
15
Total Knee Arthroplasty in Hemophilia: Survivorship and Outcomes-A Systematic Review and Meta-Analysis. 62
34756977 2022
16
The mid-term clinical outcomes of total knee arthroplasty in the management of end-stage hemophilic arthropathy. 62
35416159 2022
17
Current and Emerging Approaches for Pain Management in Hemophilic Arthropathy. 62
35020184 2022
18
The Application of Focused Medium-Energy Extracorporeal Shockwave Therapy in Hemophilic A Arthropathy. 62
35206968 2022
19
Safety and effectiveness of fascial therapy in the treatment of adult patients with hemophilic elbow arthropathy: a pilot study. 62
32223585 2022
20
Total knee replacement for patients with severe hemophilic arthropathy in Taiwan: A nationwide population-based retrospective study. 62
34698692 2022
21
Contrasting Patterns of Hemarthroses in Different Joints After Development of Hemophilic Arthropathy in a Severe Type A Hemophiliac: An Autobiographical Case Report. 62
35154927 2022
22
Comorbidities, Health-Related Quality of Life, Health-care Utilization in Older Persons with Hemophilia-Hematology Utilization Group Study Part VII (HUGS VII). 62
35585877 2022
23
Multidisciplinary Team Care of Patients with Hemophilic Arthropathy: A Qualitative Assessment of Contemporary Practice in the UK and Canada : Canada/UK: MDT Practices for Hemophilia. 62
35060765 2022
24
Artificial Intelligence Algorithm-Based Magnetic Resonance Imaging to Evaluate the Effect of Radiation Synovectomy for Hemophilic Arthropathy. 62
35360269 2022
25
Anatomical bone structure differences in patients with hemophilic arthropathy of the knee. 62
36128354 2022
26
Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential. 62
34606985 2021
27
Hemophilic arthropathy: a teaching approach devoted to hemophilia treaters in under-development countries. 62
34482789 2021
28
One Session Effects of Knee Motion Visualization Using Immersive Virtual Reality in Patients with Hemophilic Arthropathy. 62
34682847 2021
29
Hemophilic arthropathy: Current knowledge and future perspectives. 62
34197690 2021
30
Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence. 62
34318359 2021
31
Musculoskeletal Changes in Hemophilia Patients Subsequent to COVID-19 Lockdown. 62
34207821 2021
32
Pain management in people with hemophilia in childhood and young adulthood. 62
34042011 2021
33
Soft tissue releasing and serial casting for management of flexion contracture after primary total knee arthroplasty in a patient with hemophilia. 62
34049178 2021
34
Biochemical marker research in hemophilic arthropathy: A systematic review. 62
33277057 2021
35
Systemic vascular basement membrane markers linked to synovial vascular remodeling are biomarkers of hemarthrosis in patients with hemophilia. 62
33587779 2021
36
Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques. 62
33307179 2021
37
Editorial for "Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T2 Mapping". 62
33098133 2021
38
CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs. 62
31974191 2021
39
Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T2 Mapping. 62
33135834 2021
40
Ankle hemophilic arthropathy: literature review. 62
34322283 2021
41
Consensus on hemophilia in Mexico. 62
33819260 2021
42
Asymptomatic Joint Bleeding and Joint Health in Hemophilia: A Review of Variables, Methods, and Biomarkers. 62
33833602 2021
43
The Hemarthrosis-Simulating Knee Model: A Useful Tool for Individualized Education in Patients with Hemophilia (GEFACET Study). 62
33727876 2021
44
Correlation between Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score and Hemophilia Joint Health Score (HJHS) in patients with hemophilic arthropathy. 62
33826621 2021
45
Management of Musculoskeletal Complications in Patients with Hemophilia: Literature Review and Expert Recommendations. 62
33906595 2021
46
Quality of Life, Perception of Disease and Coping Strategies in Patients with Hemophilia in Spain and El Salvador: A Comparative Study. 62
34456562 2021
47
Ultrashort echo time quantitative susceptibility mapping (UTE-QSM) for detection of hemosiderin deposition in hemophilic arthropathy: A feasibility study. 62
32662904 2020
48
[Orthopedic treatment of musculoskeletal disorders in hemophilic patients]. 62
33333692 2020
49
Mid-to Long-Term Survival of Total Knee Arthroplasty in Hemophilic Arthropathy. 62
33050640 2020
50
Functionality and range of motion in patients with hemophilic ankle arthropathy treated with fascial therapy. A randomized clinical trial. 62
32861358 2020

Variations for Hemophilic Arthropathy

Expression for Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for Hemophilic Arthropathy

GO Terms for Hemophilic Arthropathy

Sources for Hemophilic Arthropathy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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