MCID: HMP018
MIFTS: 33

Hemophilic Arthropathy

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hemophilic Arthropathy

MalaCards integrated aliases for Hemophilic Arthropathy:

Name: Hemophilic Arthropathy 20 70

Classifications:



External Ids:

UMLS 70 C0263725

Summaries for Hemophilic Arthropathy

MalaCards based summary : Hemophilic Arthropathy is related to synovitis and arthropathy. An important gene associated with Hemophilic Arthropathy is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and TRAF Pathway. The drugs Ropivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 73 Haemophilia (also spelled hemophilia) is a mostly inherited genetic disorder that impairs the body's... more...

Related Diseases for Hemophilic Arthropathy

Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 synovitis 30.5 TNFSF11 TNFRSF11B COMP
2 arthropathy 29.9 TNFSF11 TNFRSF11B TNFRSF11A PTGS2 HFE COMP
3 ankylosis 29.9 TNFSF11 TNFRSF11B
4 bone resorption disease 29.5 TNFSF11 TNFRSF11B TNFRSF11A
5 osteoarthritis 29.5 TNFSF11 TNFRSF11B PTGS2 COMP
6 osteoporosis 29.1 TNFSF11 TNFRSF11B TNFRSF11A PTGS2
7 bone disease 28.9 TNFSF11 TNFRSF11B TNFRSF11A COMP
8 hemophilia 11.0
9 hemarthrosis 10.8
10 hemophilia a 10.7
11 factor viii deficiency 10.7
12 plica syndrome 10.7
13 hemophilia b 10.5
14 von willebrand's disease 10.3
15 bone mineral density quantitative trait locus 8 10.2
16 bone mineral density quantitative trait locus 15 10.2
17 b-lymphoblastic leukemia/lymphoma 10.1
18 chronic pain 10.1
19 periodontitis 10.0 TNFSF11 PTGS2
20 keratocystic odontogenic tumor 10.0 TNFSF11 PTGS2
21 polykaryocytosis inducer 10.0
22 osteoid osteoma 10.0
23 factor xi deficiency 10.0
24 bicipital tenosynovitis 10.0
25 chondromalacia 10.0
26 poliomyelitis 10.0
27 hemolytic anemia 10.0
28 acquired immunodeficiency syndrome 10.0
29 compartment syndrome 10.0
30 osgood-schlatter's disease 10.0
31 muscular atrophy 10.0
32 septic arthritis 10.0
33 tenosynovitis 10.0
34 prosthetic joint infection 10.0
35 chondroblastoma 9.9 TNFSF11 PTGS2
36 mineral metabolism disease 9.9 TNFSF11 HFE
37 aneurysmal bone cysts 9.9 TNFSF11 TNFRSF11A
38 giant cell reparative granuloma 9.9 TNFSF11 TNFRSF11A
39 tooth resorption 9.9 TNFSF11 TNFRSF11A
40 osteopetrosis, autosomal recessive 7 9.9 TNFSF11 TNFRSF11A
41 bone giant cell tumor 9.9 TNFSF11 TNFRSF11A
42 ischemic bone disease 9.9 TNFSF11 TNFRSF11A
43 fibrous dysplasia 9.9 TNFSF11 TNFRSF11A
44 periodontitis, chronic 9.8 TNFSF11 TNFRSF11B
45 multicentric reticulohistiocytosis 9.8 TNFSF11 TNFRSF11B
46 chronic apical periodontitis 9.8 TNFSF11 TNFRSF11B
47 chondrocalcinosis 9.8 TNFRSF11B HFE
48 glucocorticoid-induced osteoporosis 9.8 TNFSF11 TNFRSF11B
49 bone inflammation disease 9.8 TNFSF11 PTGS2 COMP
50 renal osteodystrophy 9.8 TNFSF11 TNFRSF11B

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to Hemophilic Arthropathy

Symptoms & Phenotypes for Hemophilic Arthropathy

MGI Mouse Phenotypes related to Hemophilic Arthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
2 growth/size/body region MP:0005378 9.8 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
3 immune system MP:0005387 9.73 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
4 limbs/digits/tail MP:0005371 9.55 COMP HFE TNFRSF11A TNFRSF11B TNFSF11
5 no phenotypic analysis MP:0003012 9.26 HFE PTGS2 TNFRSF11A TNFSF11
6 skeleton MP:0005390 9.1 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Hemophilic Arthropathy

Drugs for Hemophilic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
4 Hylan Phase 4
5 Triamcinolone hexacetonide Phase 4
6 Triamcinolone diacetate Phase 4
7 triamcinolone acetonide Phase 4
8
Rofecoxib Approved, Investigational, Withdrawn Phase 3 162011-90-7 5090
9 Antirheumatic Agents Phase 3
10 Cyclooxygenase 2 Inhibitors Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Analgesics Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 3
16 Soy Bean
17 Viscosupplements
18 Adjuvants, Immunologic
19 Protective Agents
20 Immunologic Factors
21 Fluorodeoxyglucose F18
22 Radiopharmaceuticals
23 Fluorides
24 Factor VIII

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
2 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase III Study With a Long-Term, Open-Label Extension to Evaluate the Efficacy and Safety of TRM-201 (Rofecoxib) in Patients With Hemophilic Arthropathy Not yet recruiting NCT04684511 Phase 3 TRM-201 (Rofecoxib);Placebo
3 A Proof-of-Concept Study of AC-201 Controlled-Release Tablet (CR Tablet) in Patients With Hemophilic Arthropathy Completed NCT02994147 Phase 2 Placebo;AC-201CR
4 Physiotherapy Protocol by Myofascial Therapy and Randomized Clinical Study in Patients With Hemophilic Arthropathy Unknown status NCT02433782
5 Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy Unknown status NCT02569359
6 Randomized Clinical Study on the Effectiveness of the Myofascial Therapy in the Treatment of the Hemophilic Arthropathy of Ankle Completed NCT02825667
7 Investigation of Effectiveness of Therapeutic Exercises on Target Joint Functions and Gait in Hemophilic Arthropathic Patients. Completed NCT04297696
8 Investigation of Effectiveness of Manual Therapy and Strengthening Exercises in Physiotherapy and Rehabilitation of Hemophilic Arthropathy of the Elbow Completed NCT04308876
9 External Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles. MRI Correlation. Completed NCT01232634
10 Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy Completed NCT02601170 Hyaluronic Acid Viscosupplementation
11 PET Imaging of Hemophilic Arthropathy Correlates With Clinical, Radiographic and Sonographic Assessments Completed NCT03485170
12 Physiotherapy in the Treatment of Elbow Hemophilic Arthropathy: Manual Therapy vs Educational Physiotherapy. A Pilot Sudy Completed NCT02198040
13 Effectiveness of Manual Therapy and Educational Physiotherapy in the Treatment of Hemophilic Arthropathy of the Knee. A Randomized Pilot Study Completed NCT02198014
14 Effects of COVID-19 Quarantine on the Musculoskeletal Status of Adult Hemophilia Patients. An Observational Study Recruiting NCT04491318
15 Safety and Effectiveness of a Physiotherapy Intervention Through Movement Visualization in the Approach of Pain in Patients With Hemophilic Arthropathy. Multicenter Randomized Clinical Study. Not yet recruiting NCT04237766
16 Efficacy of a Physiotherapy Intervention Through Movement Visualization in Pain Management in Patients With Hemophilic Arthropathy. Randomized Multicenter Clinical Study. Not yet recruiting NCT04549402
17 Relationship of Pain and Joint Status With the Perception of Psychosocial Factors in Patients With Hemophilic Arthropathy: A Multicenter Observational Study Not yet recruiting NCT04715100

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

Anatomical Context for Hemophilic Arthropathy

MalaCards organs/tissues related to Hemophilic Arthropathy:

40
Bone, Bone Marrow

Publications for Hemophilic Arthropathy

Articles related to Hemophilic Arthropathy:

(show top 50) (show all 455)
# Title Authors PMID Year
1
CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs. 61
31974191 2021
2
Editorial for "Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T2 Mapping". 61
33098133 2021
3
Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T2 Mapping. 61
33135834 2021
4
Manual therapy reduces the frequency of clinical hemarthrosis and improves range of motion and perceived disability in patients with hemophilic elbow arthropathy. A randomized, single-blind, clinical trial. 61
33684015 2021
5
Systemic vascular basement membrane markers linked to synovial vascular remodeling are biomarkers of hemarthrosis in patients with hemophilia. 61
33587779 2021
6
The Hemarthrosis-Simulating Knee Model: A Useful Tool for Individualized Education in Patients with Hemophilia (GEFACET Study). 61
33727876 2021
7
Ultrashort echo time quantitative susceptibility mapping (UTE-QSM) for detection of hemosiderin deposition in hemophilic arthropathy: A feasibility study. 61
32662904 2020
8
Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques. 61
33307179 2020
9
[Orthopedic treatment of musculoskeletal disorders in hemophilic patients]. 61
33333692 2020
10
Biochemical marker research in hemophilic arthropathy: A systematic review. 61
33277057 2020
11
Mid-to Long-Term Survival of Total Knee Arthroplasty in Hemophilic Arthropathy. 61
33050640 2020
12
Functionality and range of motion in patients with hemophilic ankle arthropathy treated with fascial therapy. A randomized clinical trial. 61
32861358 2020
13
The Progression of Hemophilic Arthropathy: The Role of Biomarkers. 61
33023246 2020
14
Complications of hemophilia in the elbow: current management. 61
32723183 2020
15
HJHS 2.1 and HEAD-US assessment in the hemophilic joints: How do their findings compare? 61
32815914 2020
16
Chronic pain in patients with hemophilia: is it preventable? 61
32815911 2020
17
[Virtual reality rehabilitation in paediatric patients with hemophilia. Retrospective study]. 61
33634633 2020
18
Comparison of Total Ankle Arthroplasty and Ankle Arthrodesis in End-Stage Hemophilic Arthropathy. 61
32538146 2020
19
Multislice spiral computed tomography imaging in evaluating hemophilic arthropathy. 61
32568879 2020
20
Total Knee Arthroplasty in Patients with Hemophilia: What Do We Know? 61
32884968 2020
21
Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice. 61
32613175 2020
22
EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice. 61
32294155 2020
23
Inherited coagulation disorders in Turkish children: A retrospective, single-center cohort study. 61
31980335 2020
24
A Blended Physiotherapy Intervention for Persons With Hemophilic Arthropathy: Development Study. 61
32558654 2020
25
The role of six biomarkers in diagnosis of hemophilic arthropathy: review of the literature. 61
32856434 2020
26
Serological biomarkers in hemophilic arthropathy: Can they be used to monitor bleeding and ongoing progression of blood-induced joint disease in patients with hemophilia? 61
31796337 2020
27
Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy. 61
32126380 2020
28
Yttrium-90 Synovectomy in Hemophilic Arthropathy: An Institutional Experience for 15 Years. 61
32351269 2020
29
Treatment with radiosynoviorthesis in hemophilic patients with and without inhibitor. 61
32312235 2020
30
Safety and effectiveness of fascial therapy in the treatment of adult patients with hemophilic elbow arthropathy: a pilot study. 61
32223585 2020
31
Total knee arthroplasty in hemophilia A. 61
32211475 2020
32
Muscle strength and joint health in children with hemophilia: a cross-sectional study. 61
32779413 2020
33
A case of arthroscopic ankle arthrodesis for hemophilic arthropathy of the bilateral ankles. 61
32896686 2020
34
Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis. 61
32884948 2020
35
Pathophysiological Role of Synovitis in Hemophilic Arthropathy Development: A Two-Hit Hypothesis. 61
32581836 2020
36
Joint scores in hemophilic arthropathy in children: Developing country perspectives. 61
31922470 2020
37
Corrigendum to "Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis". 61
33274241 2020
38
MRI predicts 5-year joint bleeding and development of arthropathy on radiographs in hemophilia. 61
31917842 2020
39
Curcumin: hopeful treatment of hemophilic arthropathy via inhibition of inflammation and angiogenesis. 61
31657968 2020
40
Total Ankle Replacement in Hemophilia. 61
31820705 2020
41
Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients. 61
32191714 2020
42
[Spatiotemporal regulation of thrombus formation and dissolution]. 61
33162535 2020
43
A Translational Study of TNF-Alpha Antagonists as an Adjunctive Therapy for Preventing Hemophilic Arthropathy. 61
31892201 2019
44
Genetic biomarkers related to hemarthrosis, inflammation, and cartilage structure in pediatric patients with hemophilic arthropathy. 61
31566926 2019
45
Establishing an online physical exercise program for people with hemophilia. 61
31535221 2019
46
Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice. 61
31301687 2019
47
Does Hemophilia Increase Risk of Adverse Outcomes Following Total Hip and Knee Arthroplasty? A Propensity Score-Matched Analysis of a Nationwide, Population-Based Study. 61
31337553 2019
48
TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding. 61
31465300 2019
49
Novel functions of inactive rhomboid proteins in immunity and disease. 61
31369701 2019
50
Limitations of prophylactic treatment in patients with hemophilia. 61
31157677 2019

Variations for Hemophilic Arthropathy

Expression for Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for Hemophilic Arthropathy

Pathways related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 TNFSF11 TNFRSF11B TNFRSF11A PTGS2
2
Show member pathways
12.14 TNFSF11 TNFRSF11B TNFRSF11A
3
Show member pathways
12.14 TNFSF11 TNFRSF11B TNFRSF11A PTGS2
4 12.09 TNFSF11 TNFRSF11A PTGS2
5 11.51 TNFSF11 TNFRSF11A PTGS2
6 11.46 TNFSF11 TNFRSF11A
7
Show member pathways
11.34 TNFSF11 TNFRSF11A
8
Show member pathways
11.25 TNFSF11 TNFRSF11B TNFRSF11A
9 10.79 TNFSF11 TNFRSF11B TNFRSF11A
10 10.51 TNFSF11 TNFRSF11B
11 10 TNFSF11 TNFRSF11B TNFRSF11A

GO Terms for Hemophilic Arthropathy

Biological processes related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.55 TNFSF11 TNFRSF11A
2 BMP signaling pathway GO:0030509 9.54 HFE COMP
3 response to cytokine GO:0034097 9.52 TNFRSF11A PTGS2
4 bone mineralization GO:0030282 9.51 PTGS2 COMP
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.5 TNFSF11 TNFRSF11B TNFRSF11A
6 monocyte chemotaxis GO:0002548 9.49 TNFSF11 TNFRSF11A
7 response to tumor necrosis factor GO:0034612 9.48 TNFRSF11A PTGS2
8 response to radiation GO:0009314 9.46 TNFRSF11A PTGS2
9 osteoclast differentiation GO:0030316 9.43 TNFSF11 TNFRSF11A
10 ossification GO:0001503 9.43 TNFSF11 TNFRSF11A COMP
11 positive regulation of bone resorption GO:0045780 9.4 TNFSF11 TNFRSF11A
12 mammary gland alveolus development GO:0060749 9.37 TNFSF11 TNFRSF11A
13 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFSF11 TNFRSF11A
14 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFSF11 TNFRSF11A
15 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.62 TNFSF11 TNFRSF11A

Sources for Hemophilic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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