MCID: HMR039
MIFTS: 57

Hemorrhage, Intracerebral

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Hemorrhage, Intracerebral

MalaCards integrated aliases for Hemorrhage, Intracerebral:

Name: Hemorrhage, Intracerebral 57
Hemorrhage, Intracerebral, Susceptibility to 57 29 13 6 40
Hemorrhagic Stroke 75 55 43
Ich 57 76 75
Stroke, Hemorrhagic, Susceptibility to 57 6
Intracerebral Hemorrhage 75 55
Stroke, Hemorrhagic 57
Cerebral Hemorrhage 44
Brain Hemorrhage 73

Classifications:



External Ids:

OMIM 57 614519
MeSH 44 D002543
UMLS 73 C0553692

Summaries for Hemorrhage, Intracerebral

MedlinePlus : 43 A stroke is a medical emergency. There are two types - ischemic and hemorrhagic. Hemorrhagic stroke is the less common type. It happens when a blood vessel breaks and bleeds into the brain. Within minutes, brain cells begin to die. Causes include a bleeding aneurysm, an arteriovenous malformation (AVM), or an artery wall that breaks open. Symptoms of stroke are Sudden numbness or weakness of the face, arm or leg (especially on one side of the body) Sudden confusion, trouble speaking or understanding speech Sudden trouble seeing in one or both eyes Sudden trouble walking, dizziness, loss of balance or coordination Sudden severe headache with no known cause It is important to treat strokes as quickly as possible. With a hemorrhagic stroke, the first steps are to find the cause of bleeding in the brain and then control it. Surgery may be needed. Post-stroke rehabilitation can help people overcome disabilities caused by stroke damage. National Institute of Neurological Disorders and Stroke

MalaCards based summary : Hemorrhage, Intracerebral, also known as hemorrhage, intracerebral, susceptibility to, is related to cerebral hemorrhage and cerebral amyloid angiopathy, cst3-related, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Hemorrhage, Intracerebral is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Neuroscience and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and eye, and related phenotypes are cardiovascular system and growth/size/body region

UniProtKB/Swiss-Prot : 75 Intracerebral hemorrhage: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.

Wikipedia : 76 Intracerebral hemorrhage (ICH), also known as cerebral bleed, is a type of intracranial bleed that... more...

Description from OMIM: 614519

Related Diseases for Hemorrhage, Intracerebral

Diseases related to Hemorrhage, Intracerebral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 cerebral hemorrhage 33.7 APP CST3
2 cerebral amyloid angiopathy, cst3-related 31.7 APOE APP CST3
3 cerebrovascular disease 30.3 ACE APOE APP COL4A1 PLAT
4 ischemic heart disease 29.7 ACE APOE
5 stroke, ischemic 27.8 ACE APOE HMGCR PLAT
6 heart disease 27.4 ACE APOE CST3 HMGCR
7 moyamoya disease 1 11.2
8 hyperaldosteronism, familial, type i 11.2
9 cerebral amyloid angiopathy, app-related 11.1
10 cerebral arteriosclerosis 10.9
11 familial porencephaly 10.7 COL4A1 COL4A2
12 porencephaly 1 10.7 COL4A1 COL4A2
13 angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 10.7 COL4A1 COL4A2
14 porencephaly 10.6 COL4A1 COL4A2
15 corneal dystrophy, posterior polymorphous, 3 10.5 COL4A1 COL4A2
16 coronary restenosis 10.5 ACE PLAT
17 intermediate coronary syndrome 10.4 ACE PLAT
18 hemiplegia 10.4 COL4A1 COL4A2
19 moderate and severe traumatic brain injury 10.4 ACE APOE
20 generalized atherosclerosis 10.4 ACE APOE
21 cerebral atherosclerosis 10.4 ACE APOE
22 intracranial vasospasm 10.3 APOE PLAT
23 hereditary cerebral amyloid angiopathy 10.3 APP CST3
24 senile plaque formation 10.3 APOE APP
25 aortic atherosclerosis 10.3 ACE APOE
26 hepatorenal syndrome 10.3 ACE CST3
27 systolic heart failure 10.3 ACE CST3
28 gait apraxia 10.3 APOE APP
29 familial idiopathic basal ganglia calcification 10.2 APOE APP
30 binswanger's disease 10.2 APOE APP
31 peripheral artery disease 10.2 ACE CST3
32 alzheimer disease 2 10.1 APOE APP
33 coronary stenosis 10.1 ACE APOE
34 aphasia 10.1 APOE APP
35 carotid artery disease 10.0 ACE APOE
36 marek disease 10.0 ACE HMGCR
37 pick disease of brain 10.0 APOE APP
38 carotid stenosis 10.0 ACE APOE
39 ischemia 9.9 ACE APP PLAT
40 arteries, anomalies of 9.9 ACE APOE PLAT
41 defective apolipoprotein b-100 9.8 APOE HMGCR
42 homozygous familial hypercholesterolemia 9.8 APOE HMGCR
43 aneurysm 9.8
44 hypertension, essential 9.7 ACE CST3 PLAT
45 xanthomatosis 9.7 APOE HMGCR
46 hyperlipoproteinemia, type iii 9.7 APOE HMGCR
47 amyloidosis 9.7 APOE APP CST3
48 smith-lemli-opitz syndrome 9.6 APOE HMGCR
49 brain injury 9.6
50 traumatic brain injury 9.6

Graphical network of the top 20 diseases related to Hemorrhage, Intracerebral:



Diseases related to Hemorrhage, Intracerebral

Symptoms & Phenotypes for Hemorrhage, Intracerebral

Clinical features from OMIM:

614519

UMLS symptoms related to Hemorrhage, Intracerebral:


angina pectoris, back pain, chest pain, edema, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Hemorrhage, Intracerebral:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 APP CCM2 COL4A1 COL4A2 CST3 PLAT
2 growth/size/body region MP:0005378 9.98 HMGCR PLAT ACE APOE APP CCM2
3 homeostasis/metabolism MP:0005376 9.97 PLAT ACE APOE APP CCM2 COL4A1
4 mortality/aging MP:0010768 9.97 ACE APOE APP CCM2 COL4A1 COL4A2
5 hematopoietic system MP:0005397 9.95 ACE APOE APP CCM2 COL4A1 COL4A2
6 muscle MP:0005369 9.73 APOE APP CCM2 COL4A1 CST3 PLAT
7 nervous system MP:0003631 9.7 APOE APP CCM2 COL4A1 COL4A2 CST3
8 reproductive system MP:0005389 9.43 ACE APOE APP COL4A1 CST3 PLAT
9 vision/eye MP:0005391 9.02 APOE CCM2 COL4A1 COL4A2 PLAT

Drugs & Therapeutics for Hemorrhage, Intracerebral

Drugs for Hemorrhage, Intracerebral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 357)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 4,Phase 3,Early Phase 1 55142-85-3 5472
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
3
Simvastatin Approved Phase 4,Phase 2,Not Applicable 79902-63-9 54454
4
Warfarin Approved Phase 4,Phase 3,Not Applicable 81-81-2 6691 54678486
5
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
6
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
7
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
8
Cisatracurium Approved Phase 4,Not Applicable 96946-41-7
9 Nadroparin Approved, Investigational Phase 4 9041-08-1
10
Probucol Approved, Investigational Phase 4 23288-49-5 4912
11
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
12
Nicardipine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 55985-32-5 4474
13
Cilostazol Approved, Investigational Phase 4,Phase 3,Not Applicable 73963-72-1 2754
14
Clevidipine Approved, Investigational Phase 4,Phase 3,Phase 2 167221-71-8
15
Dalteparin Approved Phase 4,Phase 2 9005-49-6
16
Enoxaparin Approved Phase 4,Phase 3 9005-49-6 772
17
Amlodipine Approved Phase 4 88150-42-9 2162
18
Ezetimibe Approved Phase 4 163222-33-1 150311
19
Mannitol Approved, Investigational Phase 4,Not Applicable 69-65-8 453 6251
20
Succinylcholine Approved Phase 4,Not Applicable 306-40-1 5314
21
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
22
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
23
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
24
Betamethasone Approved, Vet_approved Phase 4,Not Applicable 378-44-9 9782
25
Ethanol Approved Phase 4,Phase 1,Phase 2,Not Applicable 64-17-5 702
26
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
27
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
28
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
29
Ticagrelor Approved Phase 4 274693-27-5 9871419
30
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31
Etomidate Approved Phase 4,Not Applicable 33125-97-2 36339 667484
32
Indapamide Approved Phase 4 26807-65-8 3702
33
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
34
Losartan Approved Phase 4 114798-26-4 3961
35
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
36
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
37
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
38
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
39
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
40
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
41
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
42
Desflurane Approved Phase 4 57041-67-5 42113
43
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
44
Menadione Approved, Nutraceutical Phase 4,Phase 3,Not Applicable,Early Phase 1 58-27-5 4055
45 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
46
Phytonadione Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable,Early Phase 1 84-80-0 4812 5284607
47
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
48
Caffeine Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-08-2 2519
49
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
50
Butyric Acid Experimental, Investigational Phase 4,Phase 2,Not Applicable 107-92-6 264

Interventional clinical trials:

(show top 50) (show all 470)
# Name Status NCT ID Phase Drugs
1 Clinical Re-evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Unknown status NCT01918722 Phase 4 ICH-1(herbal medicine with Hirudo, Tabanus);placebo;ICH-2(herbal medicine without Hirudo, Tabanus)
2 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
3 Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage Unknown status NCT00699465 Phase 4 enoxaparin;enoxaparin placebo
4 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
5 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4 Nicardipine
6 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
7 ASCEND: A Study of Cardiovascular Events iN Diabetes Unknown status NCT00135226 Phase 4 aspirin;Omega-3-acid Ethyl Esters;Placebo Aspirin;Placebo omega-3-Ethyl Esters
8 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4 Recombinant tissue plasminogen activator (rt-PA);Low Molecular Weight Heparin
9 Clopidogrel for Acute Ischaemia of Recent Onset Unknown status NCT02776540 Phase 4 Clopidogrel;Aspirin
10 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
11 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
12 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4 Panax Notoginseng Saponins
13 Seizures Post Intracerebral Hemorrhage Completed NCT01115959 Phase 4 valproic acid;placebo bid
14 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4 Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
15 COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke Completed NCT00814268 Phase 4 Clopidogrel;Clopidogrel placebo;Aspirin
16 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed NCT00234065 Phase 4 Cilostazol;Aspirin
17 Temperature Control in Central Fever in the Neuro-ICU Completed NCT00751634 Phase 4
18 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
19 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed NCT00197392 Phase 4
20 Imaging Guided Patient Selection for Interventional Revascularization Therapy Completed NCT00963989 Phase 4
21 A Single-center, Prospective,Randomized Study of Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Dual Anti-platelet Therapy After Coronary Artery Bypass Grafting Completed NCT02330640 Phase 4 ticagrelor;clopidogrel;asprin
22 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
23 Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT) Completed NCT00301392 Phase 4 Life style interventions plus concomitant use of pitavastatin.
24 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
25 Study of Heart and Renal Protection Completed NCT00125593 Phase 4 Simvastatin 20 mg;Ezetimibe 10mg;Placebo
26 Danhong Injection in the Treatment of Chronic Stable Angina Completed NCT01681316 Phase 4 Danhong injection;Placebo
27 Clevidipine (Cleviprex®) Compared With Urapidil (Ebrantil®) Recruiting NCT03300479 Phase 4 Clevidipine;Urapidil
28 Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Recruiting NCT02699645 Phase 4 telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg;Placebo
29 The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris Recruiting NCT02870764 Phase 4 Dan-shen extract;Placebo
30 Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD Recruiting NCT03417388 Phase 4 High dose potent statin;PCSK9 Inhibitor;ACE-I (lisinopril) or ARB (losartan);Aspirin
31 Danhong Injection in the Treatment of Acute Ischemic Stroke Recruiting NCT01677208 Phase 4 Danhong injection;placebo
32 Shuxuetong for Prevention of Recurrence in Acute Cerebrovascular Events With Embolism Recruiting NCT03090113 Phase 4 Shuxuetong Injection;Placebo Injection
33 Study of Antithrombotic Treatment After Intracerebral Haemorrhage Not yet recruiting NCT03186729 Phase 4 Antithrombotic Agent
34 Clinical Evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Not yet recruiting NCT03354026 Phase 4 AICH-PXZY;AICH-without PXZY;AICH-placebo
35 Intervention for High-normal or Borderline-elevated Blood Pressure in Adults With Type 2 Diabetes Not yet recruiting NCT03264352 Phase 4 Allisartan Isoproxil;Amlodipine 5mg;Hydrochlorothiazide 25 mg;Allisartan Isoproxil placebo;Amlodipine placebo;Hydrochlorothiazide placebo
36 SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke Not yet recruiting NCT03263117 Phase 4 Sedation;General Anesthesia (GA)
37 Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
38 Forced Fluid Removal in High Risk Acute Kidney Injury Terminated NCT02458157 Phase 4 Furosemide (Furix)
39 The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy Withdrawn NCT01042574 Phase 4 Clevidipine butyrate
40 Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage Unknown status NCT00815737 Phase 2, Phase 3 rhubarb;Placebo
41 Pilot Study of Hypothermia for Intracerebral Hemorrhage in Croatia Unknown status NCT01221142 Phase 3
42 Edoxaban for TIA and Acute Minor Stroke Unknown status NCT02221102 Phase 2, Phase 3 Aspirin;edoxaban;placebo
43 Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events Unknown status NCT01923818 Phase 2, Phase 3 rivaroxaban;Aspirin;placebo
44 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
45 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
46 Cilostazol Stroke Prevention Study for Antiplatelet Combination Unknown status NCT01995370 Phase 3 aspirin;clopidogrel;cilostazol
47 Recombinant Factor VIIa in Acute Intracerebral Haemorrhage Completed NCT00127283 Phase 3 eptacog alfa (activated)
48 Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE) Completed NCT00666328 Phase 3 clevidipine
49 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
50 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed NCT00041938 Phase 3 aspirin;Warfarin

Search NIH Clinical Center for Hemorrhage, Intracerebral

Cochrane evidence based reviews: cerebral hemorrhage

Genetic Tests for Hemorrhage, Intracerebral

Genetic tests related to Hemorrhage, Intracerebral:

# Genetic test Affiliating Genes
1 Hemorrhage, Intracerebral, Susceptibility to 29 ACE COL4A1 COL4A2

Anatomical Context for Hemorrhage, Intracerebral

MalaCards organs/tissues related to Hemorrhage, Intracerebral:

41
Brain, Cortex, Eye, Heart, Testes, Lung, Kidney

Publications for Hemorrhage, Intracerebral

Articles related to Hemorrhage, Intracerebral:

(show top 50) (show all 105)
# Title Authors Year
1
Long-term projections of temperature-related mortality risks for ischemic stroke, hemorrhagic stroke, and acute ischemic heart disease under changing climate in Beijing, China. ( 29241068 )
2018
2
Long-term risk of hemorrhagic stroke in patients with infective endocarditis: a Danish nationwide cohort study. ( 29920590 )
2018
3
Obstructive Sleep Apnea: An Unusual Cause of Hemorrhagic Stroke. ( 29188162 )
2017
4
Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis. ( 29212462 )
2017
5
Relationship Between Bacteremia and Hemorrhagic Stroke in Patients With Continuous-Flow Left Ventricular Assist Device. ( 28943532 )
2017
6
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study. ( 28433996 )
2017
7
C-Reactive Protein Gene Contributes to the Genetic Susceptibility of Hemorrhagic Stroke in Men: a Case-Control Study in Chinese Han Population. ( 28721654 )
2017
8
Risk of Ischemic Stroke, Hemorrhagic Stroke, Bleeding, and Death in Patients Switching from Vitamin K Antagonist to Dabigatran after an Ablation. ( 27560967 )
2016
9
Influenza vaccination reduces hemorrhagic stroke risk in patients with atrial fibrillation: A population-based cohort study. ( 28089151 )
2016
10
Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population. ( 27329241 )
2016
11
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
12
Impact of systolic blood pressure on hemorrhagic stroke in patients with coronary artery disease during anti-platelet therapy: The Japanese Coronary Artery Disease (JCAD) study. ( 27648978 )
2016
13
Polymorphisms in three genes are associated with hemorrhagic stroke. ( 26664786 )
2015
14
The first documented case of hemorrhagic stroke caused by Group B streptococcal meningitis. ( 26793476 )
2015
15
Combined direct and indirect revascularization is associated with low rates of recurrent ischemic and hemorrhagic stroke in adult moyamoya disease. ( 25784009 )
2015
16
Imaging manifestations and diagnosis of a case of adult cerebral paragonimiasis with the initial symptom of hemorrhagic stroke. ( 26309598 )
2015
17
Higher ratio of ischemic stroke to hemorrhagic stroke in summer. ( 25855396 )
2015
18
Association of ACE gene I/D polymorphism and ACE levels with hemorrhagic stroke: comparison with ischemic stroke. ( 25015258 )
2015
19
Hemorrhagic stroke and cerebral paragonimiasis. ( 25270625 )
2014
20
Terson syndrome in subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury. ( 25173620 )
2014
21
Impact of proteinuria and glomerular filtration rate on risk of ischaemic and intracerebral hemorrhagic stroke: a result from the Kailuan study. ( 25346321 )
2014
22
Migraine and risk of hemorrhagic stroke: a study based on data from general practice. ( 25387444 )
2014
23
E-selectin gene (S128R) polymorphism in hemorrhagic stroke: comparison with ischemic stroke. ( 25168603 )
2014
24
Association of genetic polymorphisms at beta-adrenergic receptor with risk of intracerebral hemorrhagic stroke in North Indian population: a case control study. ( 24823730 )
2014
25
Visual disorders, the prosopometamorphopsia and prosopagnosia type in the early days after the onset of brain hemorrhagic stroke - a case report. ( 24592926 )
2014
26
Association of -1382A>G CCL11 gene variant with ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population. ( 25237944 )
2014
27
Progressive manifestations of reversible cerebral vasoconstriction syndrome presenting with subarachnoid hemorrhage, intracerebral hemorrhage, and cerebral infarction. ( 25535520 )
2014
28
CRP gene (1059G>C) polymorphism and its plasma levels in ischemic stroke and hemorrhagic stroke in a south Indian population. ( 24771073 )
2014
29
Functional electrical stimulation to ankle dorsiflexor and plantarflexor using single foot switch in patients with hemiplegia from hemorrhagic stroke. ( 25024953 )
2014
30
Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes. ( 24513482 )
2014
31
Mycotic brain aneurysm and cerebral hemorrhagic stroke: a pediatric case report. ( 23686512 )
2013
32
Prevention of venous thromboembolism in patients with hemorrhagic stroke. ( 23611851 )
2013
33
Factor XIII-A subunit Val34Leu polymorphism in fatal hemorrhagic stroke. ( 22909010 )
2013
34
Fatal hemorrhagic stroke in a Caucasian girl with moyamoya disease. ( 23549955 )
2013
35
Association of the C677T polymorphism in the MTHFR gene with hemorrhagic stroke: a meta-analysis. ( 23428159 )
2013
36
Microscopic Polyangiitis Presenting With Hemorrhagic Stroke. ( 23690295 )
2013
37
Anaplastic astrocytoma masquerading as hemorrhagic stroke. ( 23510543 )
2013
38
Migraine and hemorrhagic stroke: a meta-analysis. ( 24085027 )
2013
39
Quantitative assessment of the association between MTHFR C677T polymorphism and hemorrhagic stroke risk. ( 23184002 )
2013
40
Malignant paraganglioma presenting with hemorrhagic stroke in a child. ( 24276837 )
2013
41
Association of deep venous thrombosis with calf vein diameter in acute hemorrhagic stroke. ( 22424847 )
2013
42
Hemorrhage and risk of further hemorrhagic strokes following cerebral revascularization in Moyamoya disease: A review of the literature. ( 22937473 )
2012
43
MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke. ( 21707819 )
2012
44
BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF -196 G>A corresponds to early neurological deficit in hemorrhagic stroke. ( 22633192 )
2012
45
VAP-1/SSAO plasma activity and brain expression in human hemorrhagic stroke. ( 22133888 )
2012
46
COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke. ( 22209247 )
2012
47
Plasma I^-amyloid levels in cerebral amyloid angiopathy-associated hemorrhagic stroke. ( 22261638 )
2012
48
Endovascular cooling and endothelial activation in hemorrhagic stroke patients. ( 21380565 )
2012
49
Migraine with aura--indication of an increased risk of hemorrhagic stroke in women (Women's Health Study) and increased risk of overall death in an Icelandic population (Reykjavik Study). ( 21252164 )
2011
50
NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model. ( 21725748 )
2011

Variations for Hemorrhage, Intracerebral

UniProtKB/Swiss-Prot genetic disease variations for Hemorrhage, Intracerebral:

75
# Symbol AA change Variation ID SNP ID
1 COL4A1 p.Pro352Leu VAR_073810
2 COL4A1 p.Arg538Gly VAR_073811

ClinVar genetic disease variations for Hemorrhage, Intracerebral:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893
2 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh38 Chromosome 17, 63488531: 63488532
3 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh37 Chromosome 13, 111143601: 111143601
4 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh38 Chromosome 13, 110491254: 110491254
5 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant risk factor rs200786329 GRCh37 Chromosome 13, 110853814: 110853814
6 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant risk factor rs200786329 GRCh38 Chromosome 13, 110201467: 110201467
7 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh37 Chromosome 13, 110839601: 110839601
8 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh38 Chromosome 13, 110187254: 110187254

Expression for Hemorrhage, Intracerebral

Search GEO for disease gene expression data for Hemorrhage, Intracerebral.

Pathways for Hemorrhage, Intracerebral

GO Terms for Hemorrhage, Intracerebral

Cellular components related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.88 ACE APOE APP COL4A2 CST3 PLAT
2 extracellular region GO:0005576 9.87 ACE APOE APP COL4A1 COL4A2 CST3
3 basement membrane GO:0005604 9.54 COL4A1 COL4A2 CST3
4 extracellular space GO:0005615 9.5 ACE APOE APP COL4A1 COL4A2 CST3
5 extracellular matrix GO:0031012 9.46 APOE COL4A1 COL4A2 PLAT
6 collagen type IV trimer GO:0005587 9.26 COL4A1 COL4A2
7 endoplasmic reticulum lumen GO:0005788 9.02 APOE APP COL4A1 COL4A2 CST3

Biological processes related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 APOE APP CST3
2 extracellular matrix organization GO:0030198 9.58 APP COL4A1 COL4A2
3 response to oxidative stress GO:0006979 9.5 APOE APP CST3
4 visual learning GO:0008542 9.49 APP HMGCR
5 cholesterol biosynthetic process GO:0006695 9.48 APOE HMGCR
6 negative regulation of MAP kinase activity GO:0043407 9.46 APOE HMGCR
7 negative regulation of proteolysis GO:0045861 9.37 CST3 PLAT
8 cholesterol metabolic process GO:0008203 9.33 APOE APP HMGCR
9 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.26 COL4A1 COL4A2
10 negative regulation of long-term synaptic potentiation GO:1900272 8.96 APOE APP
11 positive regulation of amyloid fibril formation GO:1905908 8.62 APOE APP

Molecular functions related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.96 COL4A1 COL4A2
2 amyloid-beta binding GO:0001540 8.62 APOE CST3

Sources for Hemorrhage, Intracerebral

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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