ICH
MCID: HMR039
MIFTS: 62

Hemorrhage, Intracerebral (ICH)

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Hemorrhage, Intracerebral

MalaCards integrated aliases for Hemorrhage, Intracerebral:

Name: Hemorrhage, Intracerebral 58
Hemorrhage, Intracerebral, Susceptibility to 58 30 13 6 41
Intracerebral Hemorrhage 76 56 17
Hemorrhagic Stroke 76 56 44
Ich 58 77 76
Stroke, Hemorrhagic, Susceptibility to 58 6
Stroke, Hemorrhagic 58
Cerebral Hemorrhage 45
Brain Hemorrhage 74

Classifications:



External Ids:

OMIM 58 614519
MeSH 45 D002543
UMLS 74 C0553692

Summaries for Hemorrhage, Intracerebral

MedlinePlus : 44 A stroke is a medical emergency. There are two types - ischemic and hemorrhagic. Hemorrhagic stroke is the less common type. It happens when a blood vessel breaks and bleeds into the brain. Within minutes, brain cells begin to die. Causes include a bleeding aneurysm, an arteriovenous malformation (AVM), or an artery wall that breaks open. Symptoms of stroke are Sudden numbness or weakness of the face, arm or leg (especially on one side of the body) Sudden confusion, trouble speaking or understanding speech Sudden trouble seeing in one or both eyes Sudden trouble walking, dizziness, loss of balance or coordination Sudden severe headache with no known cause It is important to treat strokes as quickly as possible. With a hemorrhagic stroke, the first steps are to find the cause of bleeding in the brain and then control it. Surgery may be needed. Post-stroke rehabilitation can help people overcome disabilities caused by stroke damage. National Institute of Neurological Disorders and Stroke

MalaCards based summary : Hemorrhage, Intracerebral, also known as hemorrhage, intracerebral, susceptibility to, is related to cerebral hemorrhage and cerebral amyloid angiopathy, app-related, and has symptoms including seizures, tremor and angina pectoris. An important gene associated with Hemorrhage, Intracerebral is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Neuroscience and Microglia Activation During Neuroinflammation: Overview. The drugs Aspirin and Probucol have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and eye, and related phenotypes are cardiovascular system and growth/size/body region

UniProtKB/Swiss-Prot : 76 Intracerebral hemorrhage: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.

Wikipedia : 77 The killdeer (Charadrius vociferus) is a large plover found in the Americas. It was described and given... more...

Description from OMIM: 614519

Related Diseases for Hemorrhage, Intracerebral

Diseases related to Hemorrhage, Intracerebral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 447)
# Related Disease Score Top Affiliating Genes
1 cerebral hemorrhage 33.8 APP CST3
2 cerebral amyloid angiopathy, app-related 33.6 APP CST3
3 familial porencephaly 32.0 COL4A1 COL4A2
4 amyloidosis 30.4 APOE APP CST3
5 porencephaly 29.9 COL4A1 COL4A2
6 ischemia 29.9 ACE APP PLAT
7 hereditary cerebral amyloid angiopathy 29.8 APP CST3
8 granulomatous angiitis 29.8 ACE CST3
9 hemiplegia 29.6 COL4A1 COL4A2
10 chronic kidney failure 29.6 ACE CST3 HMGCR
11 ischemic heart disease 29.6 ACE APOE
12 cerebral amyloid angiopathy, cst3-related 29.5 APOE APP CST3
13 kidney disease 29.4 ACE APOE CST3 HMGCR
14 carotid stenosis 29.3 ACE APOE
15 lipid metabolism disorder 29.3 ACE APOE HMGCR
16 coronary artery anomaly 29.3 ACE HMGCR PLAT
17 arteriosclerosis 29.3 ACE APOE HMGCR
18 hypertension, essential 29.3 ACE CST3 PLAT
19 arteries, anomalies of 29.2 ACE APOE PLAT
20 aphasia 29.2 APOE APP
21 cerebrovascular disease 29.0 ACE APOE APP COL4A1 PLAT
22 heart disease 28.9 ACE APOE CST3 PLAT
23 diabetes mellitus, noninsulin-dependent 28.9 ACE APOE HMGCR PLAT
24 myocardial infarction 28.8 ACE APOE CST3 HMGCR PLAT
25 vascular disease 28.6 ACE APOE CST3 HMGCR PLAT
26 stroke, ischemic 28.6 ACE APOE CST3 HMGCR PLAT
27 brain ischemia 11.5
28 eclampsia 11.4
29 factor vii deficiency 11.2
30 moyamoya disease 6 with or without achalasia 11.2
31 cerebral cavernous malformation, familial 11.2
32 brain small vessel disease 1 with or without ocular anomalies 11.0
33 cerebral cavernous malformations 2 11.0
34 cerebral cavernous malformations 3 11.0
35 cavernous hemangioma 11.0
36 cerebellar degeneration 11.0
37 col4a1-related brain small-vessel disease 11.0
38 vascular erectile tumor 11.0
39 cerebral arteriosclerosis 11.0
40 congenital vascular cavernous malformations 11.0
41 familial hemangioma 11.0
42 cerebral cavernous malformations 11.0
43 thrombocytopenia 1 11.0
44 angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 10.3 COL4A1 COL4A2
45 corneal dystrophy, posterior polymorphous, 3 10.2 COL4A1 COL4A2
46 anterolateral myocardial infarction 10.2 ACE PLAT
47 intermediate coronary syndrome 10.2 ACE PLAT
48 marek disease 10.2 ACE HMGCR
49 hepatorenal syndrome 10.2 ACE CST3
50 systolic heart failure 10.2 ACE CST3

Graphical network of the top 20 diseases related to Hemorrhage, Intracerebral:



Diseases related to Hemorrhage, Intracerebral

Symptoms & Phenotypes for Hemorrhage, Intracerebral

Clinical features from OMIM:

614519

UMLS symptoms related to Hemorrhage, Intracerebral:


seizures, tremor, angina pectoris, edema, back pain, pain, chest pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Hemorrhage, Intracerebral:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.08 ACE APOE APP CCM2 COL4A1 COL4A2
2 growth/size/body region MP:0005378 10.06 ACE APOE APP CCM2 COL4A1 COL4A2
3 homeostasis/metabolism MP:0005376 10.06 ACE APOE APP CCM2 COL4A1 COL4A2
4 hematopoietic system MP:0005397 9.98 ACE APOE APP CCM2 COL4A1 COL4A2
5 mortality/aging MP:0010768 9.97 ACE APOE APP CCM2 COL4A1 COL4A2
6 immune system MP:0005387 9.91 ACE APOE APP CCM2 COL4A1 COL4A2
7 muscle MP:0005369 9.8 APOE APP CCM2 COL4A1 COL4A2 CST3
8 nervous system MP:0003631 9.7 APOE APP CCM2 COL4A1 COL4A2 CST3
9 reproductive system MP:0005389 9.5 ACE APOE APP COL4A1 COL4A2 CST3
10 vision/eye MP:0005391 9.02 APOE CCM2 COL4A1 COL4A2 PLAT

Drugs & Therapeutics for Hemorrhage, Intracerebral

Drugs for Hemorrhage, Intracerebral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 375)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Probucol Approved, Investigational Phase 4 23288-49-5 4912
3
Cilostazol Approved, Investigational Phase 4,Not Applicable 73963-72-1 2754
4
Enoxaparin Approved Phase 4,Phase 3,Phase 2 9005-49-6 772
5
Nicardipine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 55985-32-5 4474
6
Dalteparin Approved Phase 4,Phase 2,Not Applicable 9005-49-6
7
Nadroparin Approved, Investigational Phase 4
8
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
9
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
10
Cisatracurium Approved Phase 4,Not Applicable 96946-41-7
11
Phylloquinone Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 84-80-0
12
Warfarin Approved Phase 4,Phase 3,Not Applicable 81-81-2 6691 54678486
13
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 1401-55-4
14
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
15
Simvastatin Approved Phase 4,Phase 2,Not Applicable 79902-63-9 54454
16
Clevidipine Approved, Investigational Phase 4,Phase 3,Phase 2 167221-71-8
17
Etomidate Approved Phase 4,Not Applicable 33125-97-2 36339 667484
18
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
19
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
20
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
21
Mannitol Approved, Investigational Phase 4,Not Applicable 69-65-8 453 6251
22
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
23
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
25
Caffeine Approved Phase 4,Phase 1,Phase 2 58-08-2 2519
26
Sodium Citrate Approved, Investigational Phase 4 68-04-2
27
Ticagrelor Approved Phase 4 274693-27-5 9871419
28
Amlodipine Approved Phase 4,Phase 3,Not Applicable 88150-42-9 2162
29
Angiotensin II Approved, Investigational Phase 4,Phase 3,Not Applicable 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
30
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 130881 158781
31
Pitavastatin Approved Phase 4 147526-32-7, 147511-69-1 6366718 5282452
32
Ethanol Approved Phase 4,Phase 1,Phase 2,Not Applicable 64-17-5 702
33
Ezetimibe Approved Phase 4 163222-33-1 150311
34
Succinylcholine Approved Phase 4,Not Applicable 306-40-1 5314
35
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
36
Atorvastatin Approved Phase 4,Not Applicable 134523-00-5 60823
37
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10102-43-9 145068
38
Esmolol Approved Phase 4,Phase 3,Not Applicable 103598-03-4, 81147-92-4 59768
39
Nitroprusside Approved, Investigational Phase 4,Phase 3,Not Applicable 15078-28-1 11963622
40
Betamethasone Approved, Vet_approved Phase 4,Not Applicable 378-44-9 9782
41
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
42
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
43
Desflurane Approved Phase 4 57041-67-5 42113
44
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
45
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
46
Losartan Approved Phase 4 114798-26-4 3961
47
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
48
Tirofiban Approved Phase 4 144494-65-5 60947
49
carbamide peroxide Approved Phase 4 124-43-6
50
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440

Interventional clinical trials:

(show top 50) (show all 535)
# Name Status NCT ID Phase Drugs
1 Clinical Re-evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Unknown status NCT01918722 Phase 4 ICH-1(herbal medicine with Hirudo, Tabanus);placebo;ICH-2(herbal medicine without Hirudo, Tabanus)
2 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
3 Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage Unknown status NCT00699465 Phase 4 enoxaparin;enoxaparin placebo
4 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
5 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4 Nicardipine
6 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
7 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4 Recombinant tissue plasminogen activator (rt-PA);Low Molecular Weight Heparin
8 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
9 The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris Unknown status NCT02870764 Phase 4 Dan-shen extract;Placebo
10 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
11 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4 Panax Notoginseng Saponins
12 Seizures Post Intracerebral Hemorrhage Completed NCT01115959 Phase 4 valproic acid;placebo bid
13 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4 Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
14 Low-dose Versus Standard Dose Alteplase in Acute Ischemic Stroke , 4 Monthes Prospective Study Completed NCT03847883 Phase 4 Intravenous Solution Ateplase
15 COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke Completed NCT00814268 Phase 4 Clopidogrel;Clopidogrel placebo;Aspirin
16 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed NCT00234065 Phase 4 Cilostazol;Aspirin
17 Temperature Control in Central Fever in the Neuro-ICU Completed NCT00751634 Phase 4
18 Clopidogrel for Acute Ischaemia of Recent Onset Completed NCT02776540 Phase 4 Clopidogrel;Aspirin
19 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
20 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed NCT00197392 Phase 4
21 Imaging Guided Patient Selection for Interventional Revascularization Therapy Completed NCT00963989 Phase 4
22 A Single-center, Prospective,Randomized Study of Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Dual Anti-platelet Therapy After Coronary Artery Bypass Grafting Completed NCT02330640 Phase 4 ticagrelor;clopidogrel;asprin
23 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
24 Cilostazol Stroke Prevention Study for Antiplatelet Combination Completed NCT01995370 Phase 4 aspirin;clopidogrel;cilostazol
25 Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT) Completed NCT00301392 Phase 4 Life style interventions plus concomitant use of pitavastatin.
26 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
27 Study of Heart and Renal Protection Completed NCT00125593 Phase 4 Simvastatin 20 mg;Ezetimibe 10mg;Placebo
28 Danhong Injection in the Treatment of Chronic Stable Angina Completed NCT01681316 Phase 4 Danhong injection;Placebo
29 Study of Antithrombotic Treatment After IntraCerebral Haemorrhage Recruiting NCT03186729 Phase 4 Antithrombotic Agent
30 Clevidipine (Cleviprex®) Compared With Urapidil (Ebrantil®) Recruiting NCT03300479 Phase 4 Clevidipine;Urapidil
31 Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial Recruiting NCT03772847 Phase 4 ginkgolide
32 Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke Recruiting NCT03661411 Phase 4 Aspirin;Clopidogrel 75mg;Alteplase
33 SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke Recruiting NCT03263117 Phase 4 Sedation;General Anesthesia (GA)
34 Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD Recruiting NCT03417388 Phase 4 High dose potent statin;ACE-I (lisinopril) or ARB (losartan);Aspirin
35 Danhong Injection in the Treatment of Acute Ischemic Stroke Recruiting NCT01677208 Phase 4 Danhong injection;placebo
36 Shuxuetong for Prevention of Recurrence in Acute Cerebrovascular Events With Embolism Recruiting NCT03090113 Phase 4 Shuxuetong Injection;Placebo Injection
37 ASCEND: A Study of Cardiovascular Events iN Diabetes Active, not recruiting NCT00135226 Phase 4 aspirin;Omega-3-acid Ethyl Esters;Placebo Aspirin;Placebo omega-3-Ethyl Esters
38 Clinical Evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Not yet recruiting NCT03354026 Phase 4 AICH-PXZY;AICH-without PXZY;AICH-placebo
39 Esmolol for the Treatment of Hypertension After Intracerebral Hemorrhage Study (ETHICHS) Not yet recruiting NCT03743103 Phase 4 Brevibloc, 10 Mg/mL Intravenous Solution;Nitroprusside, Sodium
40 Intervention for High-normal or Borderline-elevated Blood Pressure in Adults With Type 2 Diabetes Not yet recruiting NCT03264352 Phase 4 Allisartan Isoproxil;Amlodipine 5mg;Hydrochlorothiazide 25 mg;Allisartan Isoproxil placebo;Amlodipine placebo;Hydrochlorothiazide placebo
41 Early Initiation of Low Dose Tirofiban for Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction Not yet recruiting NCT03797729 Phase 4 Tirofiban;Normal saline
42 Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
43 Forced Fluid Removal in High Risk Acute Kidney Injury Terminated NCT02458157 Phase 4 Furosemide (Furix)
44 The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy Withdrawn NCT01042574 Phase 4 Clevidipine butyrate
45 Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage Unknown status NCT00815737 Phase 2, Phase 3 rhubarb;Placebo
46 Pilot Study of Hypothermia for Intracerebral Hemorrhage in Croatia Unknown status NCT01221142 Phase 3
47 Edoxaban for TIA and Acute Minor Stroke Unknown status NCT02221102 Phase 2, Phase 3 Aspirin;edoxaban;placebo
48 Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events Unknown status NCT01923818 Phase 2, Phase 3 rivaroxaban;Aspirin;placebo
49 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
50 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%

Search NIH Clinical Center for Hemorrhage, Intracerebral

Cochrane evidence based reviews: cerebral hemorrhage

Genetic Tests for Hemorrhage, Intracerebral

Genetic tests related to Hemorrhage, Intracerebral:

# Genetic test Affiliating Genes
1 Hemorrhage, Intracerebral, Susceptibility to 30

Anatomical Context for Hemorrhage, Intracerebral

MalaCards organs/tissues related to Hemorrhage, Intracerebral:

42
Brain, Cortex, Eye, Kidney, Heart, Bone, Testes

Publications for Hemorrhage, Intracerebral

Articles related to Hemorrhage, Intracerebral:

(show top 50) (show all 671)
# Title Authors Year
1
Non-Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Atrial Fibrillation Patients With Intracerebral Hemorrhage. ( 30869568 )
2019
2
Tolvaptan Attenuated Brain Edema in Experimental Intracerebral Hemorrhage. ( 30703371 )
2019
3
Lipoxin A4 Methyl Ester Reduces Early Brain Injury by Inhibition of the Nuclear Factor Kappa B (NF-κB)-Dependent Matrix Metallopeptidase 9 (MMP-9) Pathway in a Rat Model of Intracerebral Hemorrhage. ( 30855024 )
2019
4
Inhibition of EPAC2 Attenuates Intracerebral Hemorrhage-Induced Secondary Brain Injury via the p38/BIM/Caspase-3 Pathway. ( 30607901 )
2019
5
Silent Intracerebral Hemorrhage in Patients Randomized to Stenting or Endarterectomy for Symptomatic Carotid Stenosis. ( 30732448 )
2019
6
Original Intracerebral Hemorrhage Score for the Prediction of Short-Term Mortality in Cerebral Hemorrhage: Systematic Review and Meta-Analysis. ( 30889025 )
2019
7
Quality of life and depression 3 months after intracerebral hemorrhage. ( 30907075 )
2019
8
Progressive Cerebral Ischemia and Intracerebral Hemorrhage after Indirect Revascularization for a Patient with Cerebral Proliferative Angiopathy. ( 30737070 )
2019
9
Corrigendum to Intracerebral Hemorrhage in Multiple Sclerosis: A Retrospective Cohort Study [Journal of Stroke and Cerebrovascular Diseases Volume 28, Issue 2, February 2019, Pages 267-275]. ( 30745231 )
2019
10
Modulating acute neuroinflammation in intracerebral hemorrhage: the potential promise of currently approved medications for multiple sclerosis. ( 30702002 )
2019
11
Intracerebral Hemorrhage in Multiple Sclerosis: A Retrospective Cohort Study. ( 30385221 )
2019
12
Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: Large Prospective cohort and preliminary meta-analysis. ( 30785378 )
2019
13
New Silent Cerebral Infarction in Patients with Acute Non-Cerebral Amyloid Angiopathy Intracerebral Hemorrhage as a Predictor of Recurrent Cerebrovascular Events. ( 30640895 )
2019
14
Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis. ( 30744416 )
2019
15
Obesity Paradox in Intracerebral Hemorrhage. ( 30879440 )
2019
16
Angong Niuhuang Pill as adjuvant therapy for treating acute cerebral infarction and intracerebral hemorrhage: A meta-analysis of randomized controlled trials. ( 30910581 )
2019
17
Association of Diabetes and Glycated Hemoglobin With the Risk of Intracerebral Hemorrhage: A Population-Based Cohort Study. ( 30728223 )
2019
18
Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage. ( 30771300 )
2019
19
Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage. ( 30442557 )
2019
20
Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. ( 29755784 )
2018
21
Acute Kidney Injury Following Acute Ischemic Stroke and Intracerebral Hemorrhage: A Meta-Analysis of Prevalence Rate and Mortality Risk. ( 29176313 )
2018
22
Genetic Variations of COL4A1 Gene and Intracerebral Hemorrhage Outcome: A Cohort Study in a Chinese Han Population. ( 29477007 )
2018
23
Use of 4-phenylbutyrate to define therapeutic parameters for reducing intracerebral hemorrhage and myopathy in <i>Col4a1</i> mutant mice. ( 29895609 )
2018
24
Primary central nervous system lymphoma presenting as growing intracerebral hemorrhage. ( 29803066 )
2018
25
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage. ( 29432410 )
2018
26
Blossoming contusions: identifying factors contributing to the expansion of traumatic intracerebral hemorrhage. ( 29303442 )
2018
27
Atrial fibrillation after acute intracerebral hemorrhage: how would the insular cortex damage interact? Reply. ( 29913056 )
2018
28
Correction: Oral anticoagulant re-initiation following intracerebral hemorrhage in non-valvular atrial fibrillation: Global survey of the practices of neurologists, neurosurgeons and thrombosis experts. ( 29795666 )
2018
29
How do anticoagulated atrial fibrillation patients who suffer ischemic stroke or spontaneous intracerebral hemorrhage differ? ( 29745996 )
2018
30
Limitations of Cerebral Oximetry in a Patient With an Intracerebral Hemorrhage and Brain Edema on Extracorporeal Membrane Oxygenation: A Case Report. ( 30543539 )
2018
31
Detrimental Role of miRNA-144-3p in Intracerebral Hemorrhage Induced Secondary Brain Injury is Mediated by Formyl Peptide Receptor 2 Downregulation Both In Vivo and In Vitro. ( 30511586 )
2018
32
Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury. ( 30315404 )
2018
33
MiR-27a-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11. ( 30337368 )
2018
34
Eupatilin inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage. ( 30344678 )
2018
35
Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction. ( 30218674 )
2018
36
Genetic Deletion of PGF2α-FP Receptor Exacerbates Brain Injury Following Experimental Intracerebral Hemorrhage. ( 30233287 )
2018
37
Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage. ( 30171865 )
2018
38
MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression. ( 30190124 )
2018
39
Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage. ( 30205109 )
2018
40
A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase. ( 30142309 )
2018
41
Acute spontaneous intracerebral hemorrhage and traumatic brain injury are the most common causes of critical illness in the ICU and have high early mortality. ( 30149796 )
2018
42
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway. ( 30048803 )
2018
43
CD163, Hemoglobin, and Secondary Brain Injury After Intracerebral Hemorrhage. ( 30031186 )
2018
44
Overexpression of adiponectin alleviates intracerebral hemorrhage-induced brain injury in rats via suppression of oxidative stress. ( 29870775 )
2018
45
Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats. ( 29879529 )
2018
46
TAR DNA Binding Protein-43 Loss of Function Induced by Phosphorylation at S409/410 Blocks Autophagic Flux and Participates in Secondary Brain Injury After Intracerebral Hemorrhage. ( 29623031 )
2018
47
Treatment of secondary brain injury by perturbing postsynaptic density protein-95-NMDA receptor interaction after intracerebral hemorrhage in rats. ( 29513122 )
2018
48
PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro. ( 29541018 )
2018
49
Increased Expression of T Cell Immunoglobulin and Mucin Domain 3 on CD14+ Monocytes Is Associated with Systemic Inflammatory Reaction and Brain Injury in Patients with Spontaneous Intracerebral Hemorrhage. ( 29310959 )
2018
50
Mechanisms and Therapeutic Targets of Depression After Intracerebral Hemorrhage. ( 30618863 )
2018

Variations for Hemorrhage, Intracerebral

UniProtKB/Swiss-Prot genetic disease variations for Hemorrhage, Intracerebral:

76
# Symbol AA change Variation ID SNP ID
1 COL4A1 p.Pro352Leu VAR_073810 rs200786329
2 COL4A1 p.Arg538Gly VAR_073811 rs397514624

ClinVar genetic disease variations for Hemorrhage, Intracerebral:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor GRCh37 Chromosome 17, 61565892: 61565893
2 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor GRCh38 Chromosome 17, 63488531: 63488532
3 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh37 Chromosome 13, 111143601: 111143601
4 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh38 Chromosome 13, 110491254: 110491254
5 COL4A2 NM_001846.3(COL4A2): c.3448C> A (p.Gln1150Lys) single nucleotide variant Likely benign rs62621875 GRCh37 Chromosome 13, 111143681: 111143681
6 COL4A2 NM_001846.3(COL4A2): c.3448C> A (p.Gln1150Lys) single nucleotide variant Likely benign rs62621875 GRCh38 Chromosome 13, 110491334: 110491334
7 COL4A2 NM_001846.3(COL4A2): c.5068G> A (p.Ala1690Thr) single nucleotide variant Likely benign rs201105747 GRCh37 Chromosome 13, 111164467: 111164467
8 COL4A2 NM_001846.3(COL4A2): c.5068G> A (p.Ala1690Thr) single nucleotide variant Likely benign rs201105747 GRCh38 Chromosome 13, 110512120: 110512120
9 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant Uncertain significance rs200786329 GRCh37 Chromosome 13, 110853814: 110853814
10 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant Uncertain significance rs200786329 GRCh38 Chromosome 13, 110201467: 110201467
11 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh37 Chromosome 13, 110839601: 110839601
12 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh38 Chromosome 13, 110187254: 110187254

Expression for Hemorrhage, Intracerebral

Search GEO for disease gene expression data for Hemorrhage, Intracerebral.

Pathways for Hemorrhage, Intracerebral

GO Terms for Hemorrhage, Intracerebral

Cellular components related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 ACE APOE APP COL4A2 CST3 PLAT
2 extracellular region GO:0005576 9.7 ACE APOE APP COL4A1 COL4A2 CST3
3 extracellular matrix GO:0031012 9.58 APOE COL4A1 COL4A2
4 collagen-containing extracellular matrix GO:0062023 9.56 APOE COL4A1 COL4A2 PLAT
5 extracellular space GO:0005615 9.5 ACE APOE APP COL4A1 COL4A2 CST3
6 collagen type IV trimer GO:0005587 9.32 COL4A1 COL4A2
7 endoplasmic reticulum lumen GO:0005788 9.02 APOE APP COL4A1 COL4A2 CST3

Biological processes related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.69 APOE APP CST3
2 negative regulation of gene expression GO:0010629 9.61 ACE APOE APP
3 cellular protein metabolic process GO:0044267 9.58 APOE APP CST3
4 extracellular matrix organization GO:0030198 9.54 APP COL4A1 COL4A2
5 visual learning GO:0008542 9.49 APP HMGCR
6 cholesterol biosynthetic process GO:0006695 9.48 APOE HMGCR
7 negative regulation of MAP kinase activity GO:0043407 9.46 APOE HMGCR
8 negative regulation of proteolysis GO:0045861 9.32 CST3 PLAT
9 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.26 COL4A1 COL4A2
10 negative regulation of long-term synaptic potentiation GO:1900272 9.16 APOE APP
11 cholesterol metabolic process GO:0008203 9.13 APOE APP HMGCR
12 positive regulation of amyloid fibril formation GO:1905908 8.62 APOE APP

Molecular functions related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL4A1 COL4A2

Sources for Hemorrhage, Intracerebral

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
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35 ICD10 via Orphanet
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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