ICH
MCID: HMR039
MIFTS: 59

Hemorrhage, Intracerebral (ICH)

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Hemorrhage, Intracerebral

MalaCards integrated aliases for Hemorrhage, Intracerebral:

Name: Hemorrhage, Intracerebral 57
Hemorrhage, Intracerebral, Susceptibility to 57 29 13 6 40
Hemorrhagic Stroke 75 55 43
Ich 57 76 75
Stroke, Hemorrhagic, Susceptibility to 57 6
Intracerebral Hemorrhage 75 55
Stroke, Hemorrhagic 57
Cerebral Hemorrhage 44
Brain Hemorrhage 73

Classifications:



External Ids:

OMIM 57 614519
MeSH 44 D002543
UMLS 73 C0553692

Summaries for Hemorrhage, Intracerebral

MedlinePlus : 43 A stroke is a medical emergency. There are two types - ischemic and hemorrhagic. Hemorrhagic stroke is the less common type. It happens when a blood vessel breaks and bleeds into the brain. Within minutes, brain cells begin to die. Causes include a bleeding aneurysm, an arteriovenous malformation (AVM), or an artery wall that breaks open. Symptoms of stroke are Sudden numbness or weakness of the face, arm or leg (especially on one side of the body) Sudden confusion, trouble speaking or understanding speech Sudden trouble seeing in one or both eyes Sudden trouble walking, dizziness, loss of balance or coordination Sudden severe headache with no known cause It is important to treat strokes as quickly as possible. With a hemorrhagic stroke, the first steps are to find the cause of bleeding in the brain and then control it. Surgery may be needed. Post-stroke rehabilitation can help people overcome disabilities caused by stroke damage. National Institute of Neurological Disorders and Stroke

MalaCards based summary : Hemorrhage, Intracerebral, also known as hemorrhage, intracerebral, susceptibility to, is related to cerebral hemorrhage and cerebral amyloid angiopathy, app-related, and has symptoms including seizures, tremor and angina pectoris. An important gene associated with Hemorrhage, Intracerebral is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Neuroscience and Microglia Activation During Neuroinflammation: Overview. The drugs Cilostazol and Probucol have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related phenotypes are cardiovascular system and growth/size/body region

UniProtKB/Swiss-Prot : 75 Intracerebral hemorrhage: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.

Wikipedia : 76 Jean Baptiste Point du Sable (before 1750 ? 1818) is honored as the first permanent non-Native-American... more...

Description from OMIM: 614519

Related Diseases for Hemorrhage, Intracerebral

Diseases related to Hemorrhage, Intracerebral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 405)
# Related Disease Score Top Affiliating Genes
1 cerebral hemorrhage 33.7 APP CST3
2 cerebral amyloid angiopathy, app-related 33.5 APP CST3
3 familial porencephaly 31.8 COL4A1 COL4A2
4 amyloidosis 30.5 APOE APP CST3
5 ischemia 29.9 ACE APP PLAT
6 hereditary cerebral amyloid angiopathy 29.8 APP CST3
7 granulomatous angiitis 29.7 ACE CST3
8 porencephaly 29.7 COL4A1 COL4A2
9 hemiplegia 29.6 COL4A1 COL4A2
10 cerebral amyloid angiopathy, cst3-related 29.6 APOE APP CST3
11 ischemic heart disease 29.5 ACE APOE
12 kidney disease 29.4 ACE APOE CST3 HMGCR
13 coronary artery anomaly 29.3 ACE HMGCR PLAT
14 arteries, anomalies of 29.3 ACE APOE PLAT
15 cerebrovascular disease 29.3 ACE APOE APP COL4A1 PLAT
16 hypertension, essential 29.3 ACE CST3 PLAT
17 aphasia 29.3 APOE APP
18 heart disease 29.1 ACE APOE CST3 PLAT
19 myocardial infarction 29.1 ACE APOE CST3 HMGCR PLAT
20 vascular disease 29.0 ACE APOE CST3 HMGCR PLAT
21 stroke, ischemic 29.0 ACE APOE CST3 HMGCR PLAT
22 brain ischemia 11.5
23 eclampsia 11.3
24 hyperaldosteronism, familial, type i 11.3
25 factor vii deficiency 11.2
26 moyamoya disease 6 with or without achalasia 11.2
27 cerebral cavernous malformation, familial 11.1
28 cerebral cavernous malformations 2 11.0
29 brain small vessel disease with or without ocular anomalies 11.0
30 cavernous hemangioma 11.0
31 cerebellar degeneration 11.0
32 col4a1-related brain small-vessel disease 11.0
33 vascular erectile tumor 11.0
34 cerebral arteriosclerosis 11.0
35 congenital vascular cavernous malformations 11.0
36 familial hemangioma 11.0
37 cerebral cavernous malformations 11.0
38 thrombocytopenia 1 11.0
39 porencephaly 1 10.2 COL4A1 COL4A2
40 angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 10.2 COL4A1 COL4A2
41 corneal dystrophy, posterior polymorphous, 3 10.2 COL4A1 COL4A2
42 anterolateral myocardial infarction 10.2 ACE PLAT
43 alzheimer disease 10.1
44 intermediate coronary syndrome 10.1 ACE PLAT
45 marek disease 10.1 ACE HMGCR
46 hepatorenal syndrome 10.1 ACE CST3
47 thrombosis 10.1
48 angina pectoris 10.1 ACE PLAT
49 systolic heart failure 10.1 ACE CST3
50 moderate and severe traumatic brain injury 10.1 ACE APOE

Graphical network of the top 20 diseases related to Hemorrhage, Intracerebral:



Diseases related to Hemorrhage, Intracerebral

Symptoms & Phenotypes for Hemorrhage, Intracerebral

Clinical features from OMIM:

614519

UMLS symptoms related to Hemorrhage, Intracerebral:


seizures, tremor, angina pectoris, edema, back pain, pain, chest pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Hemorrhage, Intracerebral:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.08 ACE APOE APP CCM2 COL4A1 COL4A2
2 growth/size/body region MP:0005378 10.06 ACE APOE APP CCM2 COL4A1 COL4A2
3 homeostasis/metabolism MP:0005376 10.06 ACE APOE APP CCM2 COL4A1 COL4A2
4 hematopoietic system MP:0005397 9.98 ACE APOE APP CCM2 COL4A1 COL4A2
5 mortality/aging MP:0010768 9.97 ACE APOE APP CCM2 COL4A1 COL4A2
6 immune system MP:0005387 9.91 ACE APOE APP CCM2 COL4A1 COL4A2
7 muscle MP:0005369 9.8 APOE APP CCM2 COL4A1 COL4A2 CST3
8 nervous system MP:0003631 9.7 APOE APP CCM2 COL4A1 COL4A2 CST3
9 reproductive system MP:0005389 9.5 ACE APOE APP COL4A1 COL4A2 CST3
10 vision/eye MP:0005391 9.02 APOE CCM2 COL4A1 COL4A2 PLAT

Drugs & Therapeutics for Hemorrhage, Intracerebral

Drugs for Hemorrhage, Intracerebral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 370)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4,Phase 3,Not Applicable 73963-72-1 2754
2
Probucol Approved, Investigational Phase 4 23288-49-5 4912
3
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
4
Enoxaparin Approved Phase 4,Phase 3,Phase 2 9005-49-6 772
5
Nicardipine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 55985-32-5 4474
6
Nadroparin Approved, Investigational Phase 4
7
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
8
Dalteparin Approved Phase 4,Phase 2 9005-49-6
9
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
10
Cisatracurium Approved Phase 4,Not Applicable 96946-41-7
11
Warfarin Approved Phase 4,Phase 3,Not Applicable 81-81-2 6691 54678486
12
Phytonadione Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 84-80-0 4812 5284607
13 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
14
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
15
Simvastatin Approved Phase 4,Phase 2,Not Applicable 79902-63-9 54454
16
Clevidipine Approved, Investigational Phase 4,Phase 3,Phase 2 167221-71-8
17
Mannitol Approved, Investigational Phase 4,Not Applicable 69-65-8 453 6251
18
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
19
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 113665-84-2, 120202-66-6 60606
21
Ticlopidine Approved Phase 4,Phase 3,Early Phase 1 55142-85-3 5472
22
Caffeine Approved Phase 4,Phase 1,Phase 2 58-08-2 2519
23
Ticagrelor Approved Phase 4 274693-27-5 9871419
24
Olmesartan Approved, Investigational Phase 4 144689-63-4, 144689-24-7 158781 130881
25
Angiotensin II Approved, Investigational Phase 4,Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
26
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
27
Ethanol Approved Phase 4,Phase 1,Phase 2,Not Applicable 64-17-5 702
28
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 5282452 6366718
29
Ezetimibe Approved Phase 4 163222-33-1 150311
30
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
31
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
32
Succinylcholine Approved Phase 4,Not Applicable 306-40-1 5314
33
Betamethasone Approved, Vet_approved Phase 4,Not Applicable 378-44-9 9782
34
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
35
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
36
Desflurane Approved Phase 4 57041-67-5 42113
37
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
38
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
39
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
40
Etomidate Approved Phase 4,Not Applicable 33125-97-2 667484 36339
41
Losartan Approved Phase 4 114798-26-4 3961
42
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
43
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
44
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
45
Menadione Approved, Nutraceutical Phase 4,Phase 3,Not Applicable,Early Phase 1 58-27-5 4055
46
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
47
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
48 Urapidil Investigational Phase 4,Phase 3,Not Applicable 34661-75-1
49 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
50 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 518)
# Name Status NCT ID Phase Drugs
1 Clinical Re-evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Unknown status NCT01918722 Phase 4 ICH-1(herbal medicine with Hirudo, Tabanus);placebo;ICH-2(herbal medicine without Hirudo, Tabanus)
2 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
3 Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage Unknown status NCT00699465 Phase 4 enoxaparin;enoxaparin placebo
4 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
5 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4 Nicardipine
6 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
7 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4 Recombinant tissue plasminogen activator (rt-PA);Low Molecular Weight Heparin
8 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
9 The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris Unknown status NCT02870764 Phase 4 Dan-shen extract;Placebo
10 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
11 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4 Panax Notoginseng Saponins
12 Seizures Post Intracerebral Hemorrhage Completed NCT01115959 Phase 4 valproic acid;placebo bid
13 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4 Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
14 COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke Completed NCT00814268 Phase 4 Clopidogrel;Clopidogrel placebo;Aspirin
15 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed NCT00234065 Phase 4 Cilostazol;Aspirin
16 Temperature Control in Central Fever in the Neuro-ICU Completed NCT00751634 Phase 4
17 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
18 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed NCT00197392 Phase 4
19 Imaging Guided Patient Selection for Interventional Revascularization Therapy Completed NCT00963989 Phase 4
20 A Single-center, Prospective,Randomized Study of Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Dual Anti-platelet Therapy After Coronary Artery Bypass Grafting Completed NCT02330640 Phase 4 ticagrelor;clopidogrel;asprin
21 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
22 Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT) Completed NCT00301392 Phase 4 Life style interventions plus concomitant use of pitavastatin.
23 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
24 Study of Heart and Renal Protection Completed NCT00125593 Phase 4 Simvastatin 20 mg;Ezetimibe 10mg;Placebo
25 Danhong Injection in the Treatment of Chronic Stable Angina Completed NCT01681316 Phase 4 Danhong injection;Placebo
26 Clevidipine (Cleviprex®) Compared With Urapidil (Ebrantil®) Recruiting NCT03300479 Phase 4 Clevidipine;Urapidil
27 Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial Recruiting NCT03772847 Phase 4 ginkgolide
28 Clopidogrel for Acute Ischaemia of Recent Onset Recruiting NCT02776540 Phase 4 Clopidogrel;Aspirin
29 Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke Recruiting NCT03661411 Phase 4 Aspirin;Clopidogrel 75mg;Alteplase
30 SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke Recruiting NCT03263117 Phase 4 Sedation;General Anesthesia (GA)
31 Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD Recruiting NCT03417388 Phase 4 High dose potent statin;ACE-I (lisinopril) or ARB (losartan);Aspirin
32 Danhong Injection in the Treatment of Acute Ischemic Stroke Recruiting NCT01677208 Phase 4 Danhong injection;placebo
33 Shuxuetong for Prevention of Recurrence in Acute Cerebrovascular Events With Embolism Recruiting NCT03090113 Phase 4 Shuxuetong Injection;Placebo Injection
34 ASCEND: A Study of Cardiovascular Events iN Diabetes Active, not recruiting NCT00135226 Phase 4 aspirin;Omega-3-acid Ethyl Esters;Placebo Aspirin;Placebo omega-3-Ethyl Esters
35 Study of Antithrombotic Treatment After Intracerebral Haemorrhage Not yet recruiting NCT03186729 Phase 4 Antithrombotic Agent
36 Clinical Evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Not yet recruiting NCT03354026 Phase 4 AICH-PXZY;AICH-without PXZY;AICH-placebo
37 Esmolol for the Treatment of Hypertension After Intracerebral Hemorrhage Study (ETHICHS) Not yet recruiting NCT03743103 Phase 4 Brevibloc, 10 Mg/mL Intravenous Solution;Nitroprusside, Sodium
38 Intervention for High-normal or Borderline-elevated Blood Pressure in Adults With Type 2 Diabetes Not yet recruiting NCT03264352 Phase 4 Allisartan Isoproxil;Amlodipine 5mg;Hydrochlorothiazide 25 mg;Allisartan Isoproxil placebo;Amlodipine placebo;Hydrochlorothiazide placebo
39 OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial Not yet recruiting NCT03759938 Phase 4 Direct oral anticoagulant (DOAC)
40 Early Initiation of Low Dose Tirofiban for Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction Not yet recruiting NCT03797729 Phase 4 Tirofiban;Normal saline
41 Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
42 Forced Fluid Removal in High Risk Acute Kidney Injury Terminated NCT02458157 Phase 4 Furosemide (Furix)
43 The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy Withdrawn NCT01042574 Phase 4 Clevidipine butyrate
44 Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage Unknown status NCT00815737 Phase 2, Phase 3 rhubarb;Placebo
45 Pilot Study of Hypothermia for Intracerebral Hemorrhage in Croatia Unknown status NCT01221142 Phase 3
46 Edoxaban for TIA and Acute Minor Stroke Unknown status NCT02221102 Phase 2, Phase 3 Aspirin;edoxaban;placebo
47 Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events Unknown status NCT01923818 Phase 2, Phase 3 rivaroxaban;Aspirin;placebo
48 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
49 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
50 Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants Unknown status NCT03024814 Phase 3 Acetaminophen;Dextrose 5

Search NIH Clinical Center for Hemorrhage, Intracerebral

Cochrane evidence based reviews: cerebral hemorrhage

Genetic Tests for Hemorrhage, Intracerebral

Genetic tests related to Hemorrhage, Intracerebral:

# Genetic test Affiliating Genes
1 Hemorrhage, Intracerebral, Susceptibility to 29 ACE COL4A1 COL4A2

Anatomical Context for Hemorrhage, Intracerebral

MalaCards organs/tissues related to Hemorrhage, Intracerebral:

41
Brain, Eye, Cortex, Heart, Kidney, Bone, Testes

Publications for Hemorrhage, Intracerebral

Articles related to Hemorrhage, Intracerebral:

(show top 50) (show all 131)
# Title Authors Year
1
Long-term projections of temperature-related mortality risks for ischemic stroke, hemorrhagic stroke, and acute ischemic heart disease under changing climate in Beijing, China. ( 29241068 )
2018
2
Hemorrhagic Stroke and Cerebral Venous Thrombosis: Rare Neurological Sequelae of Chickenpox Infection. ( 30258269 )
2018
3
Long-term risk of hemorrhagic stroke in patients with infective endocarditis: a Danish nationwide cohort study. ( 29920590 )
2018
4
Pediatric Hemorrhagic Stroke Complicates Interventions for Congenital Heart Disease: Experiences from Two Centers. ( 30511690 )
2018
5
Relation of CHA2DS2VASC Score With Hemorrhagic Stroke and Mortality in Patients Undergoing Fibrinolytic Therapy for ST Elevation Myocardial Infarction. ( 30415795 )
2018
6
Cerebral Paragonimiasis With Hemorrhagic Stroke in a Developed Country. ( 30031686 )
2018
7
Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study. ( 30271630 )
2018
8
Use of Tranexamic Acid in an Uncommon Triad: Hemorrhagic Stroke, Sickle Cell Disease and Severe Coagulopathy. ( 30299352 )
2018
9
New approaches to genetic predisposition for hemorrhagic stroke in sickle cell disease. ( 29806147 )
2018
10
Impact of Interethnic Difference of Collateral Angioarchitectures on Prevalence of Hemorrhagic Stroke in Moyamoya Disease. ( 29889273 )
2018
11
Association Between Champagne Bottle Neck Sign of Internal Carotid Artery and Ipsilateral Hemorrhagic Stroke in Patients with Moyamoya Disease. ( 29913294 )
2018
12
Assessing the Pharmacological and Therapeutic Efficacy of Traditional Chinese Medicine Liangxue Tongyu Prescription for Intracerebral Hemorrhagic Stroke in Neurological Disease Models. ( 30459599 )
2018
13
Acute Effects of Particulate Air Pollution on Ischemic Stroke and Hemorrhagic Stroke Mortality. ( 30333790 )
2018
14
Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T and A1298C) and Hemorrhagic Stroke in Moroccan Patients. ( 29555401 )
2018
15
Obstructive Sleep Apnea: An Unusual Cause of Hemorrhagic Stroke. ( 29188162 )
2017
16
Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis. ( 29212462 )
2017
17
Relationship Between Bacteremia and Hemorrhagic Stroke in Patients With Continuous-Flow Left Ventricular Assist Device. ( 28943532 )
2017
18
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study. ( 28433996 )
2017
19
Rare but critical: Postpartum eclampsia presenting as hemorrhagic stroke. ( 28549627 )
2017
20
Herpes zoster and the risk of ischemic and hemorrhagic stroke: A systematic review and meta-analysis. ( 28178287 )
2017
21
Hyperglycemia and diabetes have different impacts on outcome of ischemic and hemorrhagic stroke. ( 28144261 )
2017
22
Risks of newly onset hemorrhagic stroke in patients with neovascular age-related macular degeneration. ( 28856767 )
2017
23
An Uncommon Cause of Hemorrhagic Stroke: The Marchiafava-Micheli Disease. ( 27564565 )
2017
24
C-Reactive Protein Gene Contributes to the Genetic Susceptibility of Hemorrhagic Stroke in Men: a Case-Control Study in Chinese Han Population. ( 28721654 )
2017
25
A Therapeutic Target of Cerebral Hemorrhagic Stroke: Matrix Metalloproteinase- 9. ( 28460607 )
2017
26
Role of TLR4 (C1196T) and CD14 (C-260T) Polymorphisms in Development of Ischemic Stroke, Its Subtypes and Hemorrhagic Stroke. ( 28963650 )
2017
27
Risk of Ischemic Stroke, Hemorrhagic Stroke, Bleeding, and Death in Patients Switching from Vitamin K Antagonist to Dabigatran after an Ablation. ( 27560967 )
2016
28
Influenza vaccination reduces hemorrhagic stroke risk in patients with atrial fibrillation: A population-based cohort study. ( 28089151 )
2016
29
Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population. ( 27329241 )
2016
30
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
31
Impact of systolic blood pressure on hemorrhagic stroke in patients with coronary artery disease during anti-platelet therapy: The Japanese Coronary Artery Disease (JCAD) study. ( 27648978 )
2016
32
Coexistence of Deep Vein Thrombosis, Heterotopic Ossification, and Complex Regional Pain Syndrome due to Hemorrhagic Stroke. ( 26774869 )
2016
33
Effect of stress hyperglycemia and intensive rehabilitation therapy in non-diabetic hemorrhagic stroke: Korean Stroke Cohort for Functioning and Rehabilitation. ( 27444813 )
2016
34
Honeycomb-like appearance in the brain of a former boxer with hyperhomocysteinemia, severe carotid disease and hemorrhagic stroke. ( 26763038 )
2016
35
Hemorrhagic Stroke Resulting From Venous Malformation at 20 Weeks of Pregnancy. ( 27999514 )
2016
36
Polymorphisms in three genes are associated with hemorrhagic stroke. ( 26664786 )
2015
37
The first documented case of hemorrhagic stroke caused by Group B streptococcal meningitis. ( 26793476 )
2015
38
Combined direct and indirect revascularization is associated with low rates of recurrent ischemic and hemorrhagic stroke in adult moyamoya disease. ( 25784009 )
2015
39
Imaging manifestations and diagnosis of a case of adult cerebral paragonimiasis with the initial symptom of hemorrhagic stroke. ( 26309598 )
2015
40
Higher ratio of ischemic stroke to hemorrhagic stroke in summer. ( 25855396 )
2015
41
Hemorrhagic stroke, cerebral amyloid angiopathy, Down syndrome and the Boston criteria. ( 26048609 )
2015
42
Combined Direct and Indirect Revascularization is Associated With Low Rates of Recurrent Ischemic and Hemorrhagic Stroke in Adult Moyamoya Disease. ( 28171614 )
2015
43
Structural causes of ischemic and hemorrhagic stroke in children: moyamoya and arteriovenous malformations. ( 26474344 )
2015
44
Association of ACE gene I/D polymorphism and ACE levels with hemorrhagic stroke: comparison with ischemic stroke. ( 25015258 )
2015
45
Hemorrhagic stroke and cerebral paragonimiasis. ( 25270625 )
2014
46
Terson syndrome in subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury. ( 25173620 )
2014
47
Impact of proteinuria and glomerular filtration rate on risk of ischaemic and intracerebral hemorrhagic stroke: a result from the Kailuan study. ( 25346321 )
2014
48
Migraine and risk of hemorrhagic stroke: a study based on data from general practice. ( 25387444 )
2014
49
E-selectin gene (S128R) polymorphism in hemorrhagic stroke: comparison with ischemic stroke. ( 25168603 )
2014
50
Association of genetic polymorphisms at beta-adrenergic receptor with risk of intracerebral hemorrhagic stroke in North Indian population: a case control study. ( 24823730 )
2014

Variations for Hemorrhage, Intracerebral

UniProtKB/Swiss-Prot genetic disease variations for Hemorrhage, Intracerebral:

75
# Symbol AA change Variation ID SNP ID
1 COL4A1 p.Pro352Leu VAR_073810
2 COL4A1 p.Arg538Gly VAR_073811 rs397514624

ClinVar genetic disease variations for Hemorrhage, Intracerebral:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893
2 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh38 Chromosome 17, 63488531: 63488532
3 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh37 Chromosome 13, 111143601: 111143601
4 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh38 Chromosome 13, 110491254: 110491254
5 COL4A2 NM_001846.3(COL4A2): c.3448C> A (p.Gln1150Lys) single nucleotide variant Likely benign rs62621875 GRCh37 Chromosome 13, 111143681: 111143681
6 COL4A2 NM_001846.3(COL4A2): c.3448C> A (p.Gln1150Lys) single nucleotide variant Likely benign rs62621875 GRCh38 Chromosome 13, 110491334: 110491334
7 COL4A2 NM_001846.3(COL4A2): c.5068G> A (p.Ala1690Thr) single nucleotide variant Likely benign rs201105747 GRCh37 Chromosome 13, 111164467: 111164467
8 COL4A2 NM_001846.3(COL4A2): c.5068G> A (p.Ala1690Thr) single nucleotide variant Likely benign rs201105747 GRCh38 Chromosome 13, 110512120: 110512120
9 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant Uncertain significance rs200786329 GRCh37 Chromosome 13, 110853814: 110853814
10 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant Uncertain significance rs200786329 GRCh38 Chromosome 13, 110201467: 110201467
11 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh37 Chromosome 13, 110839601: 110839601
12 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh38 Chromosome 13, 110187254: 110187254

Expression for Hemorrhage, Intracerebral

Search GEO for disease gene expression data for Hemorrhage, Intracerebral.

Pathways for Hemorrhage, Intracerebral

GO Terms for Hemorrhage, Intracerebral

Cellular components related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 ACE APOE APP COL4A2 CST3 PLAT
2 extracellular region GO:0005576 9.7 ACE APOE APP COL4A1 COL4A2 CST3
3 extracellular matrix GO:0031012 9.58 APOE COL4A1 COL4A2
4 collagen-containing extracellular matrix GO:0062023 9.56 APOE COL4A1 COL4A2 PLAT
5 extracellular space GO:0005615 9.5 ACE APOE APP COL4A1 COL4A2 CST3
6 collagen type IV trimer GO:0005587 9.32 COL4A1 COL4A2
7 endoplasmic reticulum lumen GO:0005788 9.02 APOE APP COL4A1 COL4A2 CST3

Biological processes related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.69 APOE APP CST3
2 negative regulation of gene expression GO:0010629 9.61 ACE APOE APP
3 cellular protein metabolic process GO:0044267 9.58 APOE APP CST3
4 extracellular matrix organization GO:0030198 9.54 APP COL4A1 COL4A2
5 visual learning GO:0008542 9.49 APP HMGCR
6 cholesterol biosynthetic process GO:0006695 9.48 APOE HMGCR
7 negative regulation of MAP kinase activity GO:0043407 9.46 APOE HMGCR
8 negative regulation of proteolysis GO:0045861 9.32 CST3 PLAT
9 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.26 COL4A1 COL4A2
10 negative regulation of long-term synaptic potentiation GO:1900272 9.16 APOE APP
11 cholesterol metabolic process GO:0008203 9.13 APOE APP HMGCR
12 positive regulation of amyloid fibril formation GO:1905908 8.62 APOE APP

Molecular functions related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL4A1 COL4A2

Sources for Hemorrhage, Intracerebral

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