Aliases & Classifications for Hemorrhagic Cystitis

MalaCards integrated aliases for Hemorrhagic Cystitis:

Name: Hemorrhagic Cystitis 12 55 15 73

External Ids:

Disease Ontology 12 DOID:0050859
UMLS 73 C0085692

Summaries for Hemorrhagic Cystitis

MalaCards based summary : Hemorrhagic Cystitis is related to cystitis and hematopoietic stem cell transplantation. An important gene associated with Hemorrhagic Cystitis is IL11 (Interleukin 11), and among its related pathways/superpathways are BMP Pathway and TRAF Pathway. The drugs Cyclophosphamide and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and t cells.

Wikipedia : 76 Hemorrhagic cystitis or Haemorrhagic cystitis is defined by lower urinary tract symptoms that include... more...

Related Diseases for Hemorrhagic Cystitis

Graphical network of the top 20 diseases related to Hemorrhagic Cystitis:



Diseases related to Hemorrhagic Cystitis

Symptoms & Phenotypes for Hemorrhagic Cystitis

Drugs & Therapeutics for Hemorrhagic Cystitis

Drugs for Hemorrhagic Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
2
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
3 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
9 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
10 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
11 Hormones Phase 4,Phase 2,Phase 3,Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
13 Immunoglobulin A Phase 4,Phase 3
14 Angiotensin-Converting Enzyme Inhibitors Phase 4
15
Fludarabine Approved Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
16
Vidarabine Approved, Investigational Phase 3,Phase 1,Phase 2 24356-66-9 32326 21704
17
Azathioprine Approved Phase 2, Phase 3,Phase 3 446-86-6 2265
18
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3,Phase 3 83-43-2 6741
19
Prednisolone Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-24-8 5755
20
rituximab Approved Phase 2, Phase 3,Phase 3 174722-31-7 10201696
21
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
22
Mesna Approved, Investigational Phase 3,Phase 2,Phase 1 3375-50-6 598
23
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
24
Busulfan Approved, Investigational Phase 3,Phase 1,Phase 2 55-98-1 2478
25
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
26
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
28
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
29 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
30 Antilymphocyte Serum Phase 3,Phase 2
31 Antimetabolites Phase 3,Phase 2,Phase 1
32 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
33 Antiviral Agents Phase 3,Phase 2,Phase 1,Not Applicable
34 Antiemetics Phase 2, Phase 3,Phase 3,Phase 1
35 Autonomic Agents Phase 2, Phase 3,Phase 3,Phase 1
36 Gastrointestinal Agents Phase 2, Phase 3,Phase 3,Phase 1
37 Methylprednisolone acetate Phase 2, Phase 3,Phase 3
38 Methylprednisolone Hemisuccinate Phase 2, Phase 3,Phase 3
39 Neuroprotective Agents Phase 2, Phase 3,Phase 3
40 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Phase 1
41 Prednisolone acetate Phase 2, Phase 3,Phase 3
42 Prednisolone hemisuccinate Phase 2, Phase 3,Phase 3
43 Prednisolone phosphate Phase 2, Phase 3,Phase 3
44 Protective Agents Phase 2, Phase 3,Phase 3
45 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
46 Antineoplastic Agents, Phytogenic Phase 3,Phase 1
47 Etoposide phosphate Phase 3,Phase 1
48 Topoisomerase Inhibitors Phase 3,Phase 1
49 Antibodies Phase 3,Phase 1,Phase 2
50 gamma-Globulins Phase 3

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Extended Follow-up of Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT03218852 Phase 4 prednisone and cyclophosphamide;prednisone alone
2 Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT01758120 Phase 4 prednisone plus cyclophosphamide;Prednisone alone
3 Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
4 Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis Completed NCT00104299 Phase 2, Phase 3 Rituximab plus cyclophosphamide placebo (rituximab group);Cyclophosphamide plus rituximab placebo (control group);Azathioprine;Methylprednisolone (or other glucocorticoid);Prednisone
5 Cyclophosphamide for Acute Exacerbation of Idiopathic Pulmonary Fibrosis Recruiting NCT02460588 Phase 3 Cyclophosphamide;Placebo;Corticosteroid (prednisolone)
6 Maximizing Outcome of Multiple Sclerosis Transplantation Recruiting NCT03342638 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF
7 Rituximab in Eosinophilic Granulomatosis With Polyangiitis Recruiting NCT02807103 Phase 3 Rituximab;Placebo-rituximab;Cyclophosphamide;Placebo-cyclophosphamide
8 Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial Recruiting NCT01445821 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;Filgrastim;Fludarabine
9 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
10 A Double Blind Randomized Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis Unknown status NCT02174536 Phase 2
11 Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS) Unknown status NCT02444091 Phase 2 Cyclophosphamide
12 A Pilot Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis Completed NCT02172963 Phase 1, Phase 2
13 Efficacy and Safety of Activated Recombinant Human Factor VII in Refractory Haemorrhagic Cystitis Completed NCT01561352 Phase 2 activated recombinant human factor VII
14 Total Body Irradiation/Fludarabine Based Ablative Haploidentical Transplant for Hematologic Diseases Completed NCT01336712 Phase 2
15 Third Party Anti-Viral Cytotoxic T-Cells Recruiting NCT02532452 Phase 2
16 Anti-viral Treatment Following Bone Marrow Transplant Recruiting NCT02048332 Phase 1, Phase 2
17 GVHD Prophylaxis With Post-transplantation Bendamustine in Refractory Leukemia Recruiting NCT02799147 Phase 1, Phase 2 Fludarabine monophosphate;Busulfan;Bendamustine
18 Trial of GVHD Prophylasxis With PTCy or Thymoglobulin in Unrelated SCT Recruiting NCT02627573 Phase 2 Busulfan;Fludarabine monophosphate;Tacrolimus;Mycophenolate mofetil;Cyclophosphamide;Thymoglobulin
19 Ruxolitinib for Steroid-refractory GVHD Recruiting NCT02997280 Phase 2 Ruxolitinib Oral Tablet
20 Stem Cell Transplantation for Stiff Person Syndrome (SPS) Recruiting NCT02282514 Phase 1, Phase 2 Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF;Rituxan
21 HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide Recruiting NCT02793544 Phase 2 Fludarabine;Cyclophosphamide 14.5 mg/kg/day IV on Days -6, -5;Busulfan;Cyclophosphamide 50mg/kg/day IV on Days -2,-1;Cyclophosphamide 50mg/kg/day IV on Days -5,-4;Post-HCT Cyclophosphamide 50mg/kg IV on Day+3, +4;Sirolimus;Mycophenolate mofetil;G-CSF;Pre-HCT Mesna on Days -6 and -5;Pre-HCT Mesna on Days -2 and -1;Pre-HCT Mesna on Days -5 and -4;Post-HCT Mesna
22 Cidofovir Versus Best Supportive Care for Hemorrhagic Cystitis Active, not recruiting NCT01295645 Phase 2 Cidofovir
23 PTCy and Ruxolitinib GVHD Prophylaxis in Myelofibrosis Active, not recruiting NCT02806375 Phase 1, Phase 2 Busulfan;Fludarabine monophosphate;Cyclophosphamide;Ruxolitinib;Ruxolitinib
24 The Safety, Tolerability and Efficacy of LP-10 With Placebo in Subjects With Refractory Moderate to Severe Hemorrhagic Cystitis Not yet recruiting NCT03129126 Phase 2 Placebo;LP-10
25 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
26 Liver Transplantation With Tregs at MGH Not yet recruiting NCT03577431 Phase 1, Phase 2 cyclophosphamide;mesna;everolimus
27 BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance Terminated NCT02029638 Phase 2 Fludarabine;Low dose Pre-transplant cyclophosphamide;Acetaminophen;Diphenhydramine;Methylprednisolone;MESNA;Mycophenolate mofetil (MMF);Prednisone;Filgrastim;High dose post-transplant cyclophosphamide
28 Intravesical Cidofovir for Hemorrhagic Cystitis Completed NCT01816646 Phase 1 Cidofovir;Probenecid
29 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
30 Study of KIR-Ligand Mismatched Haplo-Identical Natural Killer Cells Transfused Before Autologous Stem Cell Transplant Completed NCT00089453 Phase 1 Dexamethasone;Cyclophosphamide;Melphalan;Fludarabine;Bortezomide;Interleukin
31 Involvement of Polyomaviruses in the Pathogenesis of Autoimmune Thyroiditis and Goitrigenesis. Recruiting NCT03103776 Not Applicable
32 Autologous Transplant Using Dose-Escalated Total Body Irradiation & Cyclophosphamide & Palifermin for NHL Recruiting NCT03042585 Not Applicable
33 Cidofovir Instillation in Hematopoietic Stem Cell Transplant (HSCT) Recipients With Hemorrhagic Cystitis Withdrawn NCT00956176 Not Applicable Cidofovir

Search NIH Clinical Center for Hemorrhagic Cystitis

Genetic Tests for Hemorrhagic Cystitis

Anatomical Context for Hemorrhagic Cystitis

MalaCards organs/tissues related to Hemorrhagic Cystitis:

41
Bone Marrow, Bone, T Cells, Liver, Brain, Spinal Cord, Thyroid

Publications for Hemorrhagic Cystitis

Articles related to Hemorrhagic Cystitis:

(show top 50) (show all 178)
# Title Authors Year
1
Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis. ( 29654564 )
2018
2
BK Viremia as a Predictor of Hemorrhagic Cystitis in Adults During the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplantation. ( 29880378 )
2018
3
Alleviation of Cyclophosphamide-induced Hemorrhagic Cystitis by Dietary Pomegranate: A Comparative Experimental Study With Mesna. ( 29734214 )
2018
4
Severe BK polyomavirus-induced hemorrhagic cystitis in a kidney transplant recipient with the absence of renal allograft involvement. ( 29143415 )
2018
5
Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis. ( 29569791 )
2018
6
Hemorrhagic cystitis associated with gefitinib treatment: a case report. ( 29958970 )
2018
7
Placenta-Derived Decidua Stromal Cells for Hemorrhagic Cystitis after Stem Cell Transplantation. ( 29408819 )
2018
8
Comparison of intravenous or intravesical cidofovir in the treatment of BK polyomavirus-associated hemorrhagic cystitis following adult allogeneic stem cell transplantation-A systematic review. ( 29797613 )
2018
9
Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant. ( 29388318 )
2018
10
Treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: the role of corticosteroids. ( 29532160 )
2018
11
High incidence of BK virus-associated hemorrhagic cystitis in children after second or third allogeneic hematopoietic stem cell transplantation. ( 29654658 )
2018
12
Hemorrhagic cystitis after hematopoietic stem cell transplantation: A challenge for the pediatric urologist. ( 29776868 )
2018
13
Equine idiopathic hemorrhagic cystitis: Clinical features and comparison with bladder neoplasia. ( 29604121 )
2018
14
Efficacy of Cidofovir in Treatment of BK Virus-Induced Hemorrhagic Cystitis in Allogeneic Hematopoietic Cell Transplant Recipients. ( 29679772 )
2018
15
Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis. ( 29613835 )
2018
16
Successful induction of therapeutic urinary concentration by intravenous ganciclovir and oral valganciclovir with remission of adenoviral hemorrhagic cystitis after cord blood transplantation. ( 29885009 )
2018
17
Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide: A Case Report. ( 29780148 )
2018
18
Re: Safety and Efficacy of Intravesical Alum for Intractable Hemorrhagic Cystitis: A Contemporary Evaluation. ( 29783557 )
2018
19
Successful Treatment of BK Virus Hemorrhagic Cystitis (HC) Post Allogenic Hematopoietic Stem Cell Transplantation with Low Dose Cidofovir. ( 28598058 )
2017
20
Hemorrhagic Cystitis in a Liver Transplant Recipient Secondary to BK Virus. ( 28516112 )
2017
21
Safety and Side Effects of Using Placenta-Derived Decidual Stromal Cells for Graft-versus-Host Disease and Hemorrhagic Cystitis. ( 28744284 )
2017
22
Conjugated Estrogen in Late-Onset Hemorrhagic Cystitis Associated with Hematopoietic Stem Cell Transplantation. ( 28286609 )
2017
23
Incidence and risk factor of hemorrhagic cystitis after allogeneic transplantation with fludarabine, busulfan, and anti-thymocyte globulin myeloablative conditioning. ( 28199755 )
2017
24
Nosocomial BK Polyomavirus Infection Causing Hemorrhagic Cystitis Among Patients With Hematological Malignancies After Hematopoietic Stem Cell Transplantation. ( 28295968 )
2017
25
Treatment of a Pediatric Case of Severe Hemorrhagic Cystitis: Case Report and Review of Literature. ( 29198679 )
2017
26
BK Virus-associated Hemorrhagic Cystitis in Patients with Allogeneic Hematopoietic Cell Transplantation: Report of Three Cases. ( 28702160 )
2017
27
Interventions to treat hemorrhagic cystitis: a systematic review and meta-analysis. ( 28462435 )
2017
28
Viral-induced Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplant. ( 28559150 )
2017
29
The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation. ( 28744217 )
2017
30
Bladder Rupture After Chronic Hemorrhagic Cystitis in a Stem Cell Transplantation Recipient. ( 28471873 )
2017
31
Rare Cyclophosphamide-Induced Hemorrhagic Cystitis in a Chinese Population with Rheumatic Diseases. ( 28646351 )
2017
32
Dynamics of BKPyV reactivation and risk of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. ( 28401591 )
2017
33
Nationwide survey of BK polyomavirus associated hemorrhagic cystitis in adult allogeneic stem cell transplantation among haematologists and urologists. ( 28160087 )
2017
34
Intravesical formalin for hemorrhagic cystitis: A contemporary cohort. ( 28360951 )
2017
35
Treatment of Severe Refractory Hematuria due to Radiation-Induced Hemorrhagic Cystitis with Dexamethasone. ( 28713429 )
2017
36
Viral-specific T-cell response in hemorrhagic cystitis after haploidentical donor stem cell transplantation. ( 28865164 )
2017
37
Hemorrhagic cystitis in pregnancy: CaseA report and review of the literature. ( 28854509 )
2017
38
Intravesical silver nitrate for refractory hemorrhagic cystitis. ( 27635296 )
2016
39
Evaluation of Hyperbaric Oxygen Therapy in the Treatment of Radiation-induced Hemorrhagic Cystitis. ( 27364865 )
2016
40
Re: A Novel Approach for the Treatment of Radiation-Induced Hemorrhagic Cystitis with the GreenLighta8c XPS Laser. ( 27597093 )
2016
41
Studies of human polyomaviruses, with HPyV7, BKPyV, and JCPyV present in urine of allogeneic hematopoietic stem cell transplanted patients with or without hemorrhagic cystitis. ( 26809742 )
2016
42
Hemostatic Efficacy and Histopathological Effects of Ankaferd Blood Stopper(Ar) in an Experimental Rat Model of Cyclophosphamide-Induced Hemorrhagic Cystitis. ( 27215482 )
2016
43
A retrospective study of treatment and prophylaxis of ifosfamide-induced hemorrhagic cystitis in pediatric and adolescent and young adult (AYA) patients with solid tumors. ( 27380806 )
2016
44
Successful treatment with intravesical cidofovir for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: A case report and a review of the literature. ( 26898668 )
2016
45
Re: Fibrin Glue Therapy for Severe Hemorrhagic Cystitis after Allogeneic Hematopoietic Stem Cell Transplantation. ( 26887714 )
2016
46
Review of Advances in Uroprotective Agents for Cyclophosphamide- and Ifosfamide-induced Hemorrhagic Cystitis. ( 27566144 )
2016
47
Incidence of sterile hemorrhagic cystitis in tumor-bearing dogs concurrently treated with oral metronomic cyclophosphamide chemotherapy and furosemide: 55 cases (2009-2015). ( 27901449 )
2016
48
Risk Factors Associated with Severity and Outcomes in Pediatric Patients with Hemorrhagic Cystitis. ( 26926552 )
2016
49
A case of BK virus nephropathy without hemorrhagic cystitis after hematopoietic stem cell transplantation. ( 27278550 )
2016
50
Re: Yildiz et al: Evaluation of Hyperbaric Oxygen Therapy in the Treatment of Radiation-induced Hemorrhagic Cystitis (Urology 2016;doi:10.1016/j.urology.2016.05.063). ( 27369819 )
2016

Variations for Hemorrhagic Cystitis

Expression for Hemorrhagic Cystitis

Search GEO for disease gene expression data for Hemorrhagic Cystitis.

Pathways for Hemorrhagic Cystitis

Pathways related to Hemorrhagic Cystitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 CYCS JUN PARP1
2
Show member pathways
12.11 CYCS JUN TLR4
3
Show member pathways
11.94 IL11 JUN TLR4
4
Show member pathways
11.93 CYCS JUN TLR4
5
Show member pathways
11.76 IL11 JUN TLR4
6
Show member pathways
11.76 CYCS JUN PARP1
7 11.31 CYCS TLR4
8
Show member pathways
11.23 CYCS PARP1
9 11.09 IL11 JUN TLR4
10 11.08 HMOX1 TLR4
11 11.06 HMOX1 JUN
12 10.96 CYCS JUN
13 10.84 HMOX1 JUN
14 10.79 CYCS PARP1
15 10.75 CYCS JUN PARP1
16 10.34 JUN TLR4
17 9.23 CYCS PARP1

GO Terms for Hemorrhagic Cystitis

Biological processes related to Hemorrhagic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.37 HMOX1 JUN
2 cellular response to cadmium ion GO:0071276 9.32 HMOX1 JUN
3 negative regulation of DNA binding GO:0043392 9.26 HMOX1 JUN
4 regulation of DNA binding transcription factor activity GO:0051090 9.16 HMOX1 JUN
5 positive regulation of transcription by RNA polymerase II GO:0045944 9.02 IL11 JUN MYSM1 PARP1 TLR4
6 cellular response to amyloid-beta GO:1904646 8.96 PARP1 TLR4

Molecular functions related to Hemorrhagic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 R-SMAD binding GO:0070412 8.62 JUN PARP1

Sources for Hemorrhagic Cystitis

3 CDC
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34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
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44 MeSH
45 MESH via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
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74 UMLS via Orphanet
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