MCID: HMR023
MIFTS: 43

Hemorrhagic Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Hemorrhagic Cystitis

MalaCards integrated aliases for Hemorrhagic Cystitis:

Name: Hemorrhagic Cystitis 12 54 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050859
UMLS 70 C0085692

Summaries for Hemorrhagic Cystitis

Disease Ontology : 12 A cystitis that is characterized by dysuria, hematuria and hemorrhage located in the lower urinary tract.

MalaCards based summary : Hemorrhagic Cystitis is related to cystitis and graft-versus-host disease. An important gene associated with Hemorrhagic Cystitis is IL11 (Interleukin 11), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Fludarabine and Sargramostim have been mentioned in the context of this disorder. Affiliated tissues include lower urinary tract, bone marrow and kidney, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Hemorrhagic cystitis or haemorrhagic cystitis is an inflammation of the bladder defined by lower urinary... more...

Related Diseases for Hemorrhagic Cystitis

Diseases related to Hemorrhagic Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 480)
# Related Disease Score Top Affiliating Genes
1 cystitis 31.8 TNF TLR4 JUN IL2
2 graft-versus-host disease 30.9 TNF IL2 HLA-A
3 acute graft versus host disease 30.8 TNF IL2 CSF3
4 pulmonary edema 30.3 TNF HMOX1 CSF3
5 acute cystitis 30.1 TNF TLR4 EPRS1 CD4
6 conjunctivitis 30.1 TNF TLR4 IL2
7 pyelonephritis 29.9 TNF TLR4 CSF3
8 acute leukemia 29.9 IL2 CSF3 CD8A CD34
9 bacterial infectious disease 29.8 TNF TLR4 CSF3 CD4
10 granulomatosis with polyangiitis 29.7 TNF TLR4 CD4 CD34
11 pancytopenia 29.7 CSF3 CD8A CD4 CD34
12 leukemia, acute lymphoblastic 29.6 TOP1 JUN IL2 CSF3 CD8A CD4
13 urethritis 29.6 TNF TLR4 CD8A CD4
14 bronchopneumonia 29.6 TNF TLR4 CD8A CD4
15 aplastic anemia 29.6 TNF IL2 IL11 HLA-A CSF3 CD4
16 keratitis, hereditary 29.6 TNF TLR4 CD8A CD4
17 testicular disease 29.6 TNF IL2 CD8A CD4
18 stomatitis 29.5 TNF IL2 CSF3 CD4
19 acute promyelocytic leukemia 29.4 TNF PARP1 JUN CSF3 CD34
20 respiratory failure 29.4 TNF TLR4 JUN CD8A CD4
21 deficiency anemia 29.3 TNF IL11 HMOX1 CSF3 CD8A CD4
22 neutropenia 29.3 TOP1 TNF IL2 IL11 CYP2B6 CSF3
23 pneumocystosis 29.1 TNF IL2 CSF3 CD8A CD4
24 human immunodeficiency virus infectious disease 29.1 TNF IL2 HLA-A CD8A CD4
25 progressive multifocal leukoencephalopathy 29.0 TNF LINC01194 IL2 CD8A CD4
26 thrombocytopenia 29.0 TOP1 TNF TLR4 IL2 IL11 HLA-A
27 leukemia, acute myeloid 28.8 TOP1 TNF JUN IL2 HLA-A CSF3
28 myeloma, multiple 28.7 TNF JUN IL2 CSF3 CD8A CD4
29 disease by infectious agent 28.7 TNF TLR4 PPIG IL2 EPRS1 CD8A
30 myelodysplastic syndrome 28.7 TOP1 TNF IL2 IL11 HLA-A CSF3
31 immune deficiency disease 28.4 TNF JUN IL2 HMOX1 HLA-A EPRS1
32 lymphoma, non-hodgkin, familial 28.3 TOP1 LINC01194 IL2 HLA-A CSF3 CD8A
33 radiation cystitis 10.4
34 urinary tract infection 10.4
35 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.3
36 hydronephrosis 10.3
37 riedel's fibrosing thyroiditis 10.3 CD4 CD34
38 third ventricle chordoid glioma 10.3 CD4 CD34
39 caplan's syndrome 10.3 HLA-A CD4
40 urinary tract obstruction 10.3
41 pyomyositis 10.3 CSF3 CD4
42 splenic abscess 10.2 CSF3 CD4
43 cork-handlers' disease 10.2 CD8A CD4
44 necrotic uveal melanoma 10.2 CD8A CD4
45 bacillary angiomatosis 10.2 CD4 CD34
46 hypersplenism 10.2 TLR4 CSF3 CD4
47 mental retardation, autosomal dominant 40 10.2 HLA-A CSF3 CD34
48 ventilation pneumonitis 10.2 CD8A CD4
49 pouchitis 10.2 TNF TLR4
50 spondylarthropathy 10.2 TNF TLR4

Graphical network of the top 20 diseases related to Hemorrhagic Cystitis:



Diseases related to Hemorrhagic Cystitis

Symptoms & Phenotypes for Hemorrhagic Cystitis

MGI Mouse Phenotypes related to Hemorrhagic Cystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 CD34 CD4 CD8A CSF3 HLA-A HMOX1
2 immune system MP:0005387 9.73 CD34 CD4 CD8A CSF3 HLA-A HMOX1
3 no phenotypic analysis MP:0003012 9.17 CD4 HLA-A IL2 JUN MAPK8IP2 PARP1

Drugs & Therapeutics for Hemorrhagic Cystitis

Drugs for Hemorrhagic Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
2
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
3
Mesna Approved, Investigational Phase 3 3375-50-6 598
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
7
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
8
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
9
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
10
Lenograstim Approved, Investigational Phase 3 135968-09-1
11
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
12
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
13
Busulfan Approved, Investigational Phase 3 55-98-1 2478
14
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
15
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
16
Etoposide Approved Phase 3 33419-42-0 36462
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
18
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
19 Antirheumatic Agents Phase 3
20 Immunosuppressive Agents Phase 3
21 Hormones Phase 3
22 Methylprednisolone Acetate Phase 3
23 Gastrointestinal Agents Phase 3
24 polysaccharide-K Phase 3
25 Neuroprotective Agents Phase 3
26 Protective Agents Phase 3
27 Antiemetics Phase 3
28 glucocorticoids Phase 3
29 Alkylating Agents Phase 3
30 Antineoplastic Agents, Hormonal Phase 3
31 Hormone Antagonists Phase 3
32 Antilymphocyte Serum Phase 3
33 Antibodies Phase 3
34 Immunologic Factors Phase 3
35 Anti-Inflammatory Agents Phase 3
36 Immunoglobulins Phase 3
37 Thymoglobulin Phase 3
38 Antifungal Agents Phase 3
39 Vitamin B9 Phase 3
40 Folic Acid Antagonists Phase 3
41 Etoposide phosphate Phase 3
42 Folate Phase 3
43 Cyclosporins Phase 3
44 Calcineurin Inhibitors Phase 3
45 Dermatologic Agents Phase 3
46 Antimetabolites Phase 3
47 Vitamin B Complex Phase 3
48
Bilirubin Phase 3 635-65-4 5280352
49 Immunoglobulin A Phase 3
50 Rho(D) Immune Globulin Phase 3

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Phase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym-M (ALVR105) for the Treatment of Patients With Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant (HCT) Recruiting NCT04390113 Phase 3
2 Randomized Study of Different Non-myeloablative Conditioning Regimens With Hematopoietic Stem Cell Support in Patients With Scleroderma (Autologous Systemic Sclerosis Immune Suppression Trial - II ASSIST-IIb) Terminated NCT01445821 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;Filgrastim;Fludarabine
3 Randomized Trial of Busulfan or Total Body Irradiation Conditioning Regimens for Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
4 Maximizing Outcome of Multiple Sclerosis Transplantation: "MOST" Trial Terminated NCT03342638 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF
5 A Double Blind Randomized Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis Unknown status NCT02174536 Phase 2
6 A Multi-Center, Phase II Trial of HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide for Patients With Hematologic Malignancies Completed NCT02793544 Phase 2 Fludarabine;Cyclophosphamide 14.5 mg/kg/day IV on Days -6, -5;Busulfan;Cyclophosphamide 50mg/kg/day IV on Days -2,-1;Cyclophosphamide 50mg/kg/day IV on Days -5,-4;Post-HCT Cyclophosphamide 50mg/kg IV on Day+3, +4;Sirolimus;Mycophenolate mofetil;G-CSF;Pre-HCT Mesna on Days -6 and -5;Pre-HCT Mesna on Days -2 and -1;Pre-HCT Mesna on Days -5 and -4;Post-HCT Mesna
7 A Pilot Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis Completed NCT02172963 Phase 1, Phase 2
8 An Open Label Pilot Study to Test the Efficacy and Safety of Recombinant Factor VIIa (rFVIIa, NovoSeven®) in the Treatment of Refractory Hemorrhagic Cystitis Following High Dose Chemotherapy Completed NCT01561352 Phase 2 activated recombinant human factor VII
9 A Phase I/II Drug Withdrawal Study of Alloantigen-Specific Tregs in Liver Transplantation Recruiting NCT03654040 Phase 1, Phase 2 cyclophosphamide;mesna;everolimus
10 A Phase I/II Drug Withdrawal Study of Alloantigen-Specific Tregs in Liver Transplantation (ITN073ST) Recruiting NCT03577431 Phase 1, Phase 2 cyclophosphamide;mesna;everolimus
11 Third Party Viral Specific T-cells (VSTs) for Treatment of Viral Infections in Immunocompromised Patients Recruiting NCT02532452 Phase 2
12 Donor-Derived Viral Specific T-cells (VSTs) for Treatment of Viral Infections After Allogeneic Stem Cell Transplant Recruiting NCT02048332 Phase 1, Phase 2
13 A Multicenter, Dose-Ranging, Placebo Controlled Trial Evaluating the Safety, Tolerability and Efficacy of LP-10 in Subjects With Refractory Moderate to Severe Hemorrhagic Cystitis Recruiting NCT03129126 Phase 2 LP-10
14 A Phase II Randomized Study of Cidofovir Versus Best Supportive Care for Polyomavirus Hominis Type I (BK) Virus Related Hemorrhagic Cystitis After Stem Cell Transplant Active, not recruiting NCT01295645 Phase 2 Cidofovir
15 Non-myeloablative Hematopoietic Stem Cell Transplantation for Stiff Person Syndrome (SPS) and Anti-GAD Antibody Variants: Progressive Encephalomyelitis With Rigidity and Myoclonus (PERM), and Adult Onset Autoimmune Anti-GAD Positive Cerebellar Ataxia Terminated NCT02282514 Phase 1, Phase 2 Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF;Rituxan
16 UARK 2003-18, A Phase II Study of KIR-Ligand Mismatched Haplo-Identical Natural Killer Cells Transfused Before Autologous Stem Cell Transplant in Relapsed Multiple Myeloma Completed NCT00089453 Phase 1 Dexamethasone;Cyclophosphamide;Melphalan;Fludarabine;Bortezomide;Interleukin
17 Intravesical Cidofovir Instillation in HSCT Recipients With Hemorrhagic Cystitis: A Single Dose Pharmacokinetic Study Completed NCT01816646 Phase 1 Cidofovir;Probenecid
18 Renal Allograft Tolerance Through Mixed Chimerism - SMC/MGH Not yet recruiting NCT04540380 Phase 1 Rituximab, Fludarabine, Cyclophosphamide, Thymic irradiation and Thymoglobulin
19 Hyperbaric Oxygen Therapy for the Treatment of Hemorrhagic Cystitis Post Allogeneic Hematopoietic Stem Cell Transplantation Recruiting NCT04502628
20 Multicenter Clinical Study of the Efficacy and Tolerability of INSTYLAN (Sodium Hyaluronate 80mg/50ml) in Patients With Early or Late Symptoms of Moderate to Severe Hemorrhagic Cystitis Caused by Pelvic Radiation Therapy and/or Chemotherapy Recruiting NCT04696666
21 Intravesical Cidofovir Instillation in HSCT Recipients With Hemorrhagic Cystitis: A Single Dose Pharmacokinetic Study Withdrawn NCT00956176 Cidofovir

Search NIH Clinical Center for Hemorrhagic Cystitis

Genetic Tests for Hemorrhagic Cystitis

Anatomical Context for Hemorrhagic Cystitis

The Foundational Model of Anatomy Ontology organs/tissues related to Hemorrhagic Cystitis:

19
Lower Urinary Tract

MalaCards organs/tissues related to Hemorrhagic Cystitis:

40
Bone Marrow, Kidney, Placenta, Lung, Myeloid, Liver, Skin

Publications for Hemorrhagic Cystitis

Articles related to Hemorrhagic Cystitis:

(show top 50) (show all 1453)
# Title Authors PMID Year
1
Re: Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. 61 54
18199361 2007
2
Re: Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. 61 54
18199362 2007
3
Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. 54 61
17980069 2007
4
Intravesical Instillation of Kangfuxin Liquid Combined with Thrombin and Epidermal Growth Factor for Radiation-induced Hemorrhagic Cystitis in Patients with Cervical Cancer: A report of 34 cases. 61
33645436 2021
5
Loss of Fibroblast Growth Factor Receptor 2 (FGFR2) Leads to Defective Bladder Urothelial Regeneration after Cyclophosphamide Injury. 61
33385344 2021
6
Ifosfamide-related encephalopathy with severe clinical presentations in children with cancer. 61
33779369 2021
7
Comparison of Total Body Irradiation-based Versus Chemotherapy-based Conditionings for Early Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Children With ALL. 61
33625092 2021
8
Prospective analysis of BKV hemorrhagic cystitis in children and adolescents undergoing hematopoietic cell transplantation. 61
33661334 2021
9
Endovascular Interventional Radiology of the Urogenital Tract. 61
33802895 2021
10
BK polyomavirus-pathogen, paradigm and puzzle. 61
31891401 2021
11
Incidence of hemorrhagic cystitis after cyclophosphamide therapy with or without mesna: A cohort study and comprehensive literature review. 61
32356687 2021
12
Risk Factors of BK Viral Hemorrhagic Cystitis in Allogenic Hematopoietic Stem Cell Transplantation. 61
33724650 2021
13
Possible nosocomial transmission of virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. 61
33439306 2021
14
Hemorrhagic cystitis: A successful outcome for a challenging complication in stem cell transplant. 61
33747409 2021
15
Effectiveness of hyperbaric oxygen therapy for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. 61
33728556 2021
16
Downregulation of redox imbalance and iNOS/NF-ĸB/caspase-3 signalling with zinc supplementation prevents urotoxicity of cyclophosphamide-induced hemorrhagic cystitis in rats. 61
33333050 2021
17
Economic and Clinical Burden of Virus-Associated Hemorrhagic Cystitis in Patients following Allogeneic Hematopoietic Stem Cell Transplantation in the United States. 61
33775616 2021
18
Protective and therapeutic effect of Hydrogen sulfide on hemorrhagic cystitis and testis dysfunction induced with Cyclophosphamide. 61
33550762 2021
19
Superselective Vesical Artery Embolization for Intractable Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation: A Single-Center Retrospective Study in 26 Patients. 61
33608760 2021
20
Adenovirus causing hepatic abscess formation and unexplained fever in adult liver transplant recipients. 61
32748558 2021
21
Outcome of a 980-nm diode laser coagulation in women with radiation-induced hemorrhagic cystitis: a single-center retrospective study. 61
32304002 2021
22
Outcome of pulse oral cyclophosphamide therapy in scleroderma interstitial lung disease. 61
32519048 2021
23
BK Polyomavirus Genotypes in Two Patients after Hematopoietic Cell Transplant. 61
33446585 2021
24
Double benefit of metformin treatment: improved bladder function in cyclophosphamide-induced cystitis and enhanced cytotoxicity in cancer cells. 61
33512558 2021
25
The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china. 61
33437210 2021
26
BK Virus Epidemiology, Risk Factors, and Clinical Outcomes: An Analysis of Hematopoietic Stem Cell Transplant Patients at Texas Children's Hospital. 61
33416086 2021
27
Super selective arterial embolization to treat radiation-induced hemorrhagic gastritis: a case report and review of the literature. 61
33380231 2021
28
The utility of hyperbaric oxygen therapy in post-transplant cyclophosphamide-induced hemorrhagic cystitis: a case report and review of the literature. 61
33397476 2021
29
Tisagenlecleucel infusion in patients with relapsed/refractory ALL and concurrent serious infection. 61
33472856 2021
30
BK Virus-Associated Urothelial Carcinoma in a Patient with Peripheral Blood Stem Cell Transplantation for Acute Lymphoblastic Leukemia: A Case Report. 61
33613235 2021
31
The Natural History of BK Polyomavirus and the Host Immune Response After Stem Cell Transplantation. 61
31851312 2020
32
Fluoroquinolones for BK viral complication after transplantation: Meta-analysis. 61
32744404 2020
33
Survey of BK Virus in Renal Transplant Recipients in Iran: A Systematic Review and Meta-Analysis. 61
33333504 2020
34
Hematopoietic Stem Cell Transplantation in Thalassemia Patients: a Jordanian Single Centre Experience. 61
33628130 2020
35
High dose cyclophosphamide for cytoreduction in patients with acute myeloid leukemia with hyperleukocytosis or leukostasis. 61
33325761 2020
36
Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients. 61
32153257 2020
37
Correction to: α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice. 61
33064165 2020
38
Multivariate analysis of factors predicting surgical intervention for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. 61
33278099 2020
39
Haploidentical stem cell transplant with post-transplantation cyclophosphamide and mini-dose methotrexate in children. 61
32224144 2020
40
First Reported Case of Hyperchloremic Non-Anion Gap Metabolic Acidosis in a Patient Undergoing Continuous Bladder Irrigation for Hemorrhagic Cystitis. 61
33489544 2020
41
Control of Archetype BK Polyomavirus MicroRNA Expression. 61
33115878 2020
42
Outcome of Canine Multicentric Lymphoma after Single or Divided Treatment with Cyclophosphamide in Multidrug Chemotherapy. 61
32823160 2020
43
Multivariate analysis of factors for failed continuous bladder irrigation in hemorrhagic cystitis patients after hematopoietic stem cell transplantation. 61
33172460 2020
44
Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. 61
33216887 2020
45
Hyperbaric oxygen for radiation-induced cystitis: A long-term follow-up. 61
32736899 2020
46
Patterns of infection and infectious-related mortality in patients receiving post-transplant high dose cyclophosphamide as graft-versus-host-disease prophylaxis: impact of HLA donor matching. 61
33106541 2020
47
α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice. 61
32415495 2020
48
BK virus infection in allogeneic hematopoietic cell transplantation: An update on pathogenesis, immune responses, diagnosis and treatments. 61
32526327 2020
49
Literature review of allograft adenovirus nephritis and a case presenting as mass lesions in a transplanted kidney without symptoms of urinary tract infection or acute kidney injury. 61
32945064 2020
50
The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis. 61
32615180 2020

Variations for Hemorrhagic Cystitis

Expression for Hemorrhagic Cystitis

Search GEO for disease gene expression data for Hemorrhagic Cystitis.

Pathways for Hemorrhagic Cystitis

Pathways related to Hemorrhagic Cystitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR4 JUN IL2 IL11 HMOX1
2
Show member pathways
13.34 TNF TLR4 MAPK8IP2 IL2 IL11 CSF3
3
Show member pathways
13.28 TNF IL2 IL11 HMOX1 HLA-A CSF3
4
Show member pathways
12.78 TNF IL2 HLA-A CD8A CD4
5
Show member pathways
12.75 TNF TLR4 JUN IL2 HLA-A
6
Show member pathways
12.51 TNF TLR4 JUN IL2 CD4
7
Show member pathways
12.5 TNF TLR4 JUN IL2 CD8A CD4
8 12.47 TNF IL2 HMOX1 CD8A CD34
9 12.23 TNF JUN IL2 HLA-A CD4
10
Show member pathways
12.11 TOP1 TNF PARP1 JUN
11
Show member pathways
12.1 TNF TLR4 JUN IL11
12 12.04 HLA-A CD8A CD4 CD34
13
Show member pathways
11.91 JUN IL2 HLA-A CD8A CD4
14 11.87 TNF TLR4 JUN IL2 CD8A CD4
15 11.81 TLR4 PARP1 IL2
16 11.78 TNF TLR4 JUN IL11
17 11.73 TNF IL2 CD8A CD4 CD34
18 11.69 TNF TLR4 JUN
19
Show member pathways
11.69 TNF JUN IL2
20
Show member pathways
11.68 TNF TLR4 JUN IL2 CD4
21 11.64 TNF IL2 CD8A CD4 CD34
22 11.63 TNF IL11 CSF3 CD8A CD4 CD34
23
Show member pathways
11.59 TNF JUN IL2
24 11.59 TNF HMOX1 CSF3
25
Show member pathways
11.5 TNF JUN IL2 HLA-A CD8A
26 11.49 TNF JUN IL2
27 11.47 TNF TLR4 CSF3
28 11.45 TNF JUN IL2
29 11.26 TNF TLR4 HMOX1
30 11.23 TNF IL2 IL11 CSF3 CD8A CD4
31 11.15 JUN IL2 CD4
32 10.96 TNF JUN IL2 IL11 CSF3
33 10.82 TNF IL2 IL11 CSF3 CD4
34 10.73 TLR4 JUN

GO Terms for Hemorrhagic Cystitis

Cellular components related to Hemorrhagic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 TNF TLR4 CD8A CD4 CD34

Biological processes related to Hemorrhagic Cystitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 TNF TLR4 PARP1 JUN IL2 IL11
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 IL11 CSF3 CD4
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.65 TNF IL11 CSF3
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.62 TNF TLR4 HMOX1 CD4
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 TNF JUN HMOX1
6 positive regulation of monocyte differentiation GO:0045657 9.46 JUN CD4
7 positive regulation of interferon-gamma production GO:0032729 9.46 TNF TLR4 IL2 HLA-A
8 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.43 TNF TLR4
9 positive regulation of chemokine production GO:0032722 9.43 TNF TLR4 HMOX1
10 cytokine-mediated signaling pathway GO:0019221 9.43 TNF IL2 IL11 HMOX1 CSF3 CD4
11 immune response GO:0006955 9.17 TNF TLR4 IL2 HLA-A CSF3 CD8A

Molecular functions related to Hemorrhagic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL2 IL11 CSF3
2 enzyme binding GO:0019899 9.02 PARP1 JUN HMOX1 CSF3 CD4

Sources for Hemorrhagic Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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