MCID: HMR012
MIFTS: 57

Hemorrhagic Fever

Categories: Genetic diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Hemorrhagic Fever

MalaCards integrated aliases for Hemorrhagic Fever:

Name: Hemorrhagic Fever 53 55
Hemorrhagic Fevers, Viral 73
Hemorrhagic Fevers 43

Classifications:



External Ids:

ICD10 33 A98.5
UMLS 73 C0019104

Summaries for Hemorrhagic Fever

MedlinePlus : 43 Viral hemorrhagic fevers (VHFs) are a group of illnesses caused by four families of viruses. These include the Ebola and Marburg, Lassa fever, and yellow fever viruses. VHFs have common features: they affect many organs, they damage the blood vessels, and they affect the body's ability to regulate itself. Some VHFs cause mild disease, but some, like Ebola or Marburg, cause severe disease and death. VHFs are found around the world. Specific diseases are usually limited to areas where the animals that carry them live. For example, Lassa fever is limited to rural areas of West Africa where rats and mice carry the virus. The risk for travelers is low, but you should avoid visiting areas where there are disease outbreaks. Because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism. Centers for Disease Control and Prevention

MalaCards based summary : Hemorrhagic Fever, also known as hemorrhagic fevers, viral, is related to marburg hemorrhagic fever and crimean-congo hemorrhagic fever, and has symptoms including fever and pruritus. An important gene associated with Hemorrhagic Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Influenza A. The drugs Ketotifen and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and t cells, and related phenotypes are cardiovascular system and homeostasis/metabolism

CDC : 3 VHFs are caused by viruses of five distinct families: Arenaviridae, Bunyaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae. Each of these families share a number of features:

Related Diseases for Hemorrhagic Fever

Diseases in the Hemorrhagic Fever family:

Viral Hemorrhagic Fever

Diseases related to Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 434)
# Related Disease Score Top Affiliating Genes
1 marburg hemorrhagic fever 34.0 CD209 F2 TNF
2 crimean-congo hemorrhagic fever 33.7 F3 IL6 TNF
3 hemorrhagic fever with renal syndrome 33.5 ALB B2M HLA-DRB1 IL6 TFRC TNF
4 korean hemorrhagic fever 33.4 F2 F3 SERPINC1
5 dengue hemorrhagic fever 32.4 ALB CD209 F2 F3 HLA-DRB1 IFNG
6 hemophagocytic lymphohistiocytosis 31.8 B2M IFNG IL10 TNF
7 dengue shock syndrome 30.8 HLA-DRB1 IL6 TNF
8 viral infectious disease 30.2 CD209 CD40LG GPT IFNG IL10 IL6
9 tick-borne encephalitis 30.1 ALB CD209 IL10
10 acute liver failure 30.1 ALB F2 GPT
11 myocarditis 30.1 CD40LG IL6 TNF
12 cholecystitis 30.1 ALB F2 GPT
13 infantile liver failure syndrome 1 29.8 ALB F2 GPT
14 severe acute respiratory syndrome 29.8 CD209 IFNG TNF
15 disseminated intravascular coagulation 29.7 F2 F3 SERPINC1
16 compartment syndrome 29.7 ALB F2 TNF
17 leptospirosis 29.7 F2 IFNG IL10 IL6 TNF
18 chlamydia 29.5 IFNG IL10 IL6 TNF
19 brucellosis 29.5 CD40LG IFNG IL10 IL6 TNF
20 pneumonia 29.5 CD40LG IL10 IL6 TNF
21 appendicitis 29.4 ALB IL10 IL6 TNF
22 visceral leishmaniasis 29.4 ALB IFNG IL10 TNF
23 kawasaki disease 29.4 ALB IL10 IL6 TNF
24 arthritis 29.4 HLA-DRB1 IFNG IL10 IL6 TNF
25 leishmaniasis 29.4 HLA-DRB1 IFNG IL10 IL6 TNF
26 scrub typhus 29.3 F3 GPT IL10 TNF
27 filariasis 29.3 ALB IFNG IL10 IL6 TNF
28 hemorrhagic disease 29.2 F2 F3 SERPINC1
29 purpura 29.1 F2 F3 IL6 SERPINC1 TNF
30 purpura fulminans 29.1 F2 F3 SERPINC1
31 typhoid fever 29.1 ALB F2 IFNG IL6 TNF
32 hepatitis b 29.1 ALB F2 GPT IFNG TNF
33 acquired immunodeficiency syndrome 29.0 ALB B2M IFNG IL10 IL6 TNF
34 hepatitis a 29.0 ALB F2 GPT IFNG IL10 TNF
35 peritonitis 28.9 ALB B2M F2 IL10 IL6 TNF
36 vascular disease 28.6 ALB F2 F3 IL6 SERPINC1 TNF
37 malaria 28.4 ALB CD40LG F3 HLA-DRB1 IFNG IL10
38 myocardial infarction 28.2 ALB CD40LG F2 F3 IL10 IL6
39 omsk hemorrhagic fever 12.7
40 argentine hemorrhagic fever 12.7
41 bolivian hemorrhagic fever 12.6
42 ebola hemorrhagic fever 12.6
43 venezuelan hemorrhagic fever 12.6
44 alkhurma hemorrhagic fever 12.6
45 lujo hemorrhagic fever 12.5
46 viral hemorrhagic fever 12.5
47 brazilian hemorrhagic fever 12.5
48 chapare hemorrhagic fever 12.4
49 whitewater arroyo hemorrhagic fever 12.3
50 balkan hemorrhagic fever 12.3

Graphical network of the top 20 diseases related to Hemorrhagic Fever:



Diseases related to Hemorrhagic Fever

Symptoms & Phenotypes for Hemorrhagic Fever

UMLS symptoms related to Hemorrhagic Fever:


fever, pruritus

MGI Mouse Phenotypes related to Hemorrhagic Fever:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.24 B2M CD40LG F2 F3 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.2 ALB B2M CD40LG F2 F3 IFNG
3 cellular MP:0005384 10.18 ALB B2M CD40LG F3 IFNG IL10
4 hematopoietic system MP:0005397 10.18 B2M CD40LG F2 F3 IFNG IL10
5 immune system MP:0005387 10.13 B2M CD40LG F2 F3 IFNG IL10
6 digestive/alimentary MP:0005381 10.11 ALB B2M F2 IFNG IL10 IL6
7 integument MP:0010771 10.06 B2M CD40LG F2 F3 IFNG IL10
8 mortality/aging MP:0010768 10.06 ALB B2M CD40LG F2 F3 IFNG
9 embryo MP:0005380 10.04 F2 F3 IFNG IL10 SERPINC1 TFRC
10 liver/biliary system MP:0005370 9.97 ALB B2M IFNG IL10 IL6 SERPINC1
11 nervous system MP:0003631 9.85 B2M CD40LG F2 F3 IFNG IL10
12 neoplasm MP:0002006 9.8 ALB B2M F3 IFNG IL10 IL6
13 reproductive system MP:0005389 9.56 B2M CD40LG F2 IFNG IL10 IL6
14 respiratory system MP:0005388 9.1 F2 F3 IFNG IL10 IL6 TNF

Drugs & Therapeutics for Hemorrhagic Fever

Drugs for Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
2
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
3 tannic acid Approved Phase 4,Phase 1,Phase 2
4
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2 94-09-7, 1994-09-7 2337
5 Anti-Allergic Agents Phase 4
6
Histamine Phosphate Phase 4 51-74-1 65513
7 Antipruritics Phase 4
8 Histamine H1 Antagonists Phase 4
9 Neurotransmitter Agents Phase 4
10 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Histamine Antagonists Phase 4
12 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Vasoconstrictor Agents Phase 4
15
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 6474909
16
Coal tar Approved Phase 2, Phase 3,Phase 1 8007-45-2
17
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
19
Lactitol Investigational Phase 3 585-86-4 3871
20 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Not Applicable
21 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
22 Antiparasitic Agents Phase 2, Phase 3,Phase 1
23 DEET Phase 3
24 Insect Repellents Phase 3
25 Protective Agents Phase 3,Phase 1
26 Antibodies Phase 3,Phase 1,Phase 2,Not Applicable
27 Immunoglobulins Phase 3,Phase 1,Phase 2,Not Applicable
28 Antibodies, Blocking Phase 3
29 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
30 Krestin Phase 3,Phase 2,Phase 1
31 Vitamins Phase 3,Phase 2
32 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
33 Keratolytic Agents Phase 2, Phase 3,Phase 1
34 Iron-Dextran Complex Phase 3
35 Retinol palmitate Phase 3
36 Antioxidants Phase 3
37 Micronutrients Phase 3
38 retinol Phase 3
39 Trace Elements Phase 3
40
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
41
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
42
Ribavirin Approved Phase 2,Not Applicable 36791-04-5 37542
43
Angiotensin II Approved, Investigational Phase 1, Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
44
Irbesartan Approved, Investigational Phase 1, Phase 2 138402-11-6 3749
45
Azithromycin Approved Phase 1, Phase 2 83905-01-5 55185 447043
46
Sunitinib Approved, Investigational Phase 1, Phase 2 557795-19-4, 341031-54-7 5329102
47
chloroquine Approved, Investigational, Vet_approved Phase 1, Phase 2 54-05-7 2719
48
Lumefantrine Approved Phase 2 82186-77-4 6437380
49
Artemether Approved Phase 2 71963-77-4 119380 68911
50
Neomycin Approved, Vet_approved Phase 1, Phase 2,Phase 2 1404-04-2 8378

Interventional clinical trials:

(show top 50) (show all 270)
# Name Status NCT ID Phase Drugs
1 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
2 High Frequency Ventilation During Off Pump Coronary Artery Bypass Graft (CABG) Completed NCT00863044 Phase 4
3 International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-Combi Recruiting NCT03072030 Phase 4
4 Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines Recruiting NCT03368495 Phase 4
5 Immunogenicity and Safety of the Yellow Fever Vaccine in HIV Infected Individuals Recruiting NCT03132311 Phase 4
6 Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines (YEFE) Active, not recruiting NCT02991495 Phase 4
7 Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study) Active, not recruiting NCT02555072 Phase 4
8 Immunogenicity of Fractional One-fifth and One-half Doses of Yellow Fever Vaccine Compared to Full Dose in Children 9-23 Months Old Not yet recruiting NCT03725618 Phase 4
9 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Unknown status NCT01374516 Phase 3
10 Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) Unknown status NCT00966628 Phase 3 Hypertonic sodium lactate;Ringer's lactate
11 Efficacy and Safety of Ivermectin Against Dengue Infection Unknown status NCT02045069 Phase 2, Phase 3 2 days Ivermectin;3 days Ivermectin;Placebo
12 Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR Unknown status NCT00938379 Phase 3 20% deet insect repellent;placebo control
13 STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) Completed NCT02378753 Phase 2, Phase 3
14 Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia Completed NCT01254422 Phase 3
15 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
16 Emergency Evaluation of Convalescent Plasma for Ebola Viral Disease (EVD) in Guinea Completed NCT02342171 Phase 2, Phase 3
17 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed NCT01411241 Phase 3
18 Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia Completed NCT01134263 Phase 3
19 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Completed NCT01373281 Phase 3
20 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed NCT01436396 Phase 3
21 Evaluation of the Safety and Immunogenicity of Three Consistency Lots and a High-Dose Lot of rVSV-ZEBOV-GP (V920 Ebola Vaccine) in Healthy Adults (V920-012) Completed NCT02503202 Phase 3
22 Providing Additional Information on the Safety and Effectiveness of an Ebola Vaccine Completed NCT03161366 Phase 3
23 Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue Completed NCT03423173 Phase 3
24 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
25 The Yellow Fever Vaccine Immunity in HIV Infected Patients : Development of New Assays for Virological and Immunological Monitoring in HIV Infected Patient. Completed NCT01426243 Phase 3
26 Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo Recruiting NCT02661464 Phase 3
27 Investigational Therapeutics for the Treatment of People With Ebola Virus Disease Recruiting NCT03719586 Phase 2, Phase 3 ZMapp;Remdesivir;MAb114;REGN-EB3
28 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Administered With a Yellow Fever Vaccine in Adults Recruiting NCT03342898 Phase 3
29 Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine Recruiting NCT02406729 Phase 3
30 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Active, not recruiting NCT02992418 Phase 3
31 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Gardasil® Active, not recruiting NCT02993757 Phase 3
32 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Cervarix® Active, not recruiting NCT02979535 Phase 3
33 Staged Phase 3 Study to Assess the Safety and Immunogenicity of Ebola Candidate Vaccines Ad26.ZEBOV and MVA-BN-Filo During Implementation of Stages 1 and 2 Active, not recruiting NCT02509494 Phase 3
34 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) in Adolescents in Non-Endemic Area(s) Active, not recruiting NCT03341637 Phase 3
35 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Co-administered With an Hepatitis A Virus Vaccine Active, not recruiting NCT03525119 Phase 3
36 Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine. Active, not recruiting NCT02699099 Phase 3
37 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) at the End of Shelf Life in Healthy Adults Not yet recruiting NCT03771963 Phase 3
38 Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola) Withdrawn NCT02307591 Phase 2, Phase 3 Best Supportive Care;Best Supportive Care + Amiodarone
39 Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms Unknown status NCT01973855 Phase 2 Western Medicine;TCM and Western Medicine
40 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2 Ribavirin
41 Multiple Treatments for Ebola Virus Disease (EVD) Unknown status NCT02380625 Phase 1, Phase 2 Azithromycin;Sunitinib and Erlotinib;Atorvastatin and Irbesartan
42 The Effect of Chloroquine in the Treatment of Patients With Dengue Unknown status NCT00849602 Phase 1, Phase 2 Placebo;Chloroquine
43 Activated Recombinant Human Factor VII in Patients With Dengue Haemorrhagic Fever Completed NCT01601613 Phase 2 activated recombinant human factor VII;placebo
44 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed NCT01187433 Phase 2
45 A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines Completed NCT01064141 Phase 2
46 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed NCT00617344 Phase 2
47 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed NCT01550289 Phase 2
48 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2
49 Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects Completed NCT00730288 Phase 2
50 Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America Completed NCT00993447 Phase 2

Search NIH Clinical Center for Hemorrhagic Fever

Genetic Tests for Hemorrhagic Fever

Anatomical Context for Hemorrhagic Fever

MalaCards organs/tissues related to Hemorrhagic Fever:

41
Testes, Endothelial, T Cells, Kidney, Liver, Heart, Monocytes

Publications for Hemorrhagic Fever

Articles related to Hemorrhagic Fever:

(show top 50) (show all 2107)
# Title Authors Year
1
Aeromedical Transfer of Patients with Viral Hemorrhagic Fever. ( 30431424 )
2019
2
Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report. ( 29508304 )
2018
3
Second International Conference on Crimean-Congo Hemorrhagic Fever. ( 29199036 )
2018
4
Lethal infection of embryonated chicken eggs by Hazara virus, a model for Crimean-Congo hemorrhagic fever virus. ( 29030708 )
2018
5
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome. ( 29450213 )
2018
6
Impact of meteorological factors on hemorrhagic fever with renal syndrome in 19 cities in China, 2005-2014. ( 29913587 )
2018
7
Notes from the Field: Crimean-Congo Hemorrhagic Fever Outbreak - Central Uganda, August-September 2017. ( 29879093 )
2018
8
Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China. ( 29524182 )
2018
9
Meteorological factors and risk of hemorrhagic fever with renal syndrome in Guangzhou, southern China, 2006-2015. ( 29949572 )
2018
10
Analysis of codon usage bias of Crimean-Congo hemorrhagic fever virus and its adaptation to hosts. ( 29198972 )
2018
11
Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor. ( 29664386 )
2018
12
Structure-Function Assays for Crimean-Congo Hemorrhagic Fever Virus Polymerase. ( 28986838 )
2018
13
Platelet Count, D-Dimer, Component Therapy and Dengue Hemorrhagic Fever. ( 29622891 )
2018
14
Climate variability and dengue hemorrhagic fever in Southeast Sulawesi Province, Indonesia. ( 29549613 )
2018
15
Seroepidemiologic Survey of Crimean-Congo Hemorrhagic Fever Virus in Selected Risk Groups, South Africa. ( 29912704 )
2018
16
Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in I1-capture and IgG immune complex (IC) ELISA tests. ( 29579040 )
2018
17
Isolation and whole-genome sequencing of a Crimean-Congo hemorrhagic fever virus strain, Greece. ( 29525552 )
2018
18
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. ( 29760382 )
2018
19
Delayed Interferon Type 1-Induced Antiviral State Is a Potential Factor for Hemorrhagic Fever With Renal Syndrome Severity. ( 29281106 )
2018
20
Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29335595 )
2018
21
Murine Models for Viral Hemorrhagic Fever. ( 28986841 )
2018
22
A Primate Model for Viral Hemorrhagic Fever. ( 28986843 )
2018
23
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. ( 29319426 )
2018
24
A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies. ( 29330092 )
2018
25
Absence of a Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Yeoncheon Compared to Nationwide Korea. ( 29968979 )
2018
26
Prospective forecasts of annual dengue hemorrhagic fever incidence in Thailand, 2010-2014. ( 29463757 )
2018
27
Crimean-Congo hemorrhagic fever with hepatic impairment and vaginal hemorrhage: a case report. ( 29724249 )
2018
28
Phylodynamics of Crimean Congo hemorrhagic fever virus in South Russia. ( 29413882 )
2018
29
Complete Genome Sequence of Dengue Virus Serotype 2, Asian/American Genotype, Isolated from the Urine of a Venezuelan Child with Hemorrhagic Fever in 2016. ( 29903824 )
2018
30
Host preferences support the prominent role of Hyalomma ticks in the ecology of Crimean-Congo hemorrhagic fever. ( 29420542 )
2018
31
The Autoimmune Mechanism in Dengue Hemorrhagic Fever. ( 29686179 )
2018
32
Crimean-Congo Hemorrhagic Fever Virus and <i>Borrelia burgdorferi</i> sensu lato in Ticks from Kosovo and Albania. ( 29560357 )
2018
33
Dynamics of viral load in Crimean Congo hemorrhagic fever. ( 29091325 )
2018
34
Culture-positive unilateral panophthalmitis in a serology-positive case of dengue hemorrhagic fever. ( 29941760 )
2018
35
Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome. ( 29373686 )
2018
36
Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient With CCHF Infection. ( 29584885 )
2018
37
Spatial-Temporal Analysis of Dengue Fever and Hemorrhagic Fever in Mexico from 1995-2015. ( 29402463 )
2018
38
Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China. ( 29520745 )
2018
39
The role of T<sub>reg</sub> population in pathogenesis of Crimean Congo hemorrhagic fever. ( 29625147 )
2018
40
The Development of a Novel Diagnostic Assay That Utilizes a Pseudotyped Vesicular Stomatitis Virus for the Detection of Neutralizing Activity against Crimean-Congo Hemorrhagic Fever Virus. ( 29709967 )
2018
41
Erratum for Madelain et al., &amp;quot;Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses&amp;quot;. ( 29269432 )
2018
42
Author Correction: Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29651028 )
2018
43
Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report. ( 29587642 )
2018
44
Landscape and rodent community composition are associated with risk of hemorrhagic fever with renal syndrome in two cities in China, 2006-2013. ( 29329512 )
2018
45
Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon. ( 29625611 )
2018
46
Study on expression of plasma sCD138 in patients with hemorrhagic fever with renal syndrome. ( 29490629 )
2018
47
A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome. ( 29563720 )
2018
48
Comparative genome analysis of Alkhumra hemorrhagic fever virus with Kyasanur forest disease and tick-borne encephalitis viruses by the in silico approach. ( 29745301 )
2018
49
Effective Population Size Differences in <i>Calomys musculinus</i>, the Host of JunA-n Virus: Its Relationship with the Epidemiological History of Argentine Hemorrhagic Fever. ( 29893205 )
2018
50
Characteristics of headache and its relationship with disease severity in patients with Crimean-Congo hemorrhagic fever. ( 29450871 )
2018

Variations for Hemorrhagic Fever

Expression for Hemorrhagic Fever

Search GEO for disease gene expression data for Hemorrhagic Fever.

Pathways for Hemorrhagic Fever

Pathways related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 B2M CD40LG HLA-DRB1 IFNG IL10 IL6
2
Show member pathways
12.74 CD209 HLA-DRB1 IFNG IL6 TNF
3
Show member pathways
12.69 B2M CD40LG HLA-DRB1 IFNG IL10 IL6
4
Show member pathways
12.57 CD40LG HLA-DRB1 IFNG IL10 TNF
5
Show member pathways
12.53 HLA-DRB1 IFNG IL10 IL6 TNF
6
Show member pathways
12.52 F2 IFNG IL10 IL6 TNF
7 12.48 B2M CD40LG IFNG IL10 TNF
8
Show member pathways
12.33 CD40LG IFNG IL10 IL6 TNF
9 12.25 B2M HLA-DRB1 IL6 TNF
10
Show member pathways
12.23 ALB F2 IFNG IL6 TNF
11
Show member pathways
12.19 IFNG IL10 IL6 TNF
12
Show member pathways
12.17 CD209 IL10 IL6 TNF
13
Show member pathways
12.13 CD40LG HLA-DRB1 IFNG IL10 TNF
14
Show member pathways
11.99 IFNG IL10 IL6 TNF
15
Show member pathways
11.96 F2 IFNG IL6 TNF
16 11.94 IFNG IL6 TNF
17 11.92 IL10 IL6 TNF
18
Show member pathways
11.91 B2M HLA-DRB1 IFNG
19 11.89 CD209 HLA-DRB1 IFNG IL10 IL6 TNF
20 11.85 IFNG IL6 TFRC
21 11.84 F3 IL6 TNF
22 11.84 HLA-DRB1 IL6 TFRC TNF
23 11.83 CD209 IFNG IL10 IL6 TNF
24 11.82 IFNG IL10 IL6 TNF
25 11.81 IFNG IL10 IL6
26 11.77 HLA-DRB1 IFNG IL6 TNF
27 11.75 IFNG IL10 TNF
28
Show member pathways
11.72 CD40LG IFNG TNF
29 11.72 IL10 IL6 TNF
30 11.63 IFNG IL10 IL6 TNF
31
Show member pathways
11.62 B2M IFNG TNF
32 11.53 IFNG IL6 TNF
33
Show member pathways
11.53 CD40LG IFNG IL6 TNF
34 11.52 CD209 IFNG IL10 IL6 TNF
35 11.5 IL10 IL6 TNF
36 11.45 IFNG IL6 TNF
37 11.44 ALB F2 TFRC
38 11.33 IL10 IL6 TNF
39 11.27 IFNG IL6 TNF
40 11.17 CD40LG IL10 IL6 TNF
41 11.17 IFNG IL10 IL6 TNF
42 11.04 CD40LG IFNG IL10 IL6 TNF
43 10.97 IL6 TNF
44 10.48 HLA-DRB1 IFNG IL10 IL6 TNF

GO Terms for Hemorrhagic Fever

Cellular components related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 B2M CD209 CD40LG F3 HLA-DRB1 TFRC
2 extracellular region GO:0005576 9.73 ALB B2M CD209 CD40LG F2 F3
3 endoplasmic reticulum lumen GO:0005788 9.72 ALB B2M F2 IL6 SERPINC1
4 external side of plasma membrane GO:0009897 9.7 B2M CD209 CD40LG F2 HLA-DRB1 TFRC
5 blood microparticle GO:0072562 9.67 ALB F2 SERPINC1 TFRC
6 HFE-transferrin receptor complex GO:1990712 9.4 B2M TFRC
7 extracellular space GO:0005615 9.4 ALB B2M CD40LG F2 F3 GPT

Biological processes related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CD40LG IL10 IL6 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.88 F3 IL10 IL6 TNF
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 IL10 IL6 TNF
4 platelet activation GO:0030168 9.77 CD40LG F2 IL6
5 viral entry into host cell GO:0046718 9.74 CD209 HLA-DRB1 TFRC
6 interferon-gamma-mediated signaling pathway GO:0060333 9.71 B2M HLA-DRB1 IFNG
7 response to glucocorticoid GO:0051384 9.7 IL10 IL6 TNF
8 humoral immune response GO:0006959 9.65 IFNG IL6 TNF
9 cellular protein metabolic process GO:0044267 9.65 ALB B2M F2 IL6 SERPINC1
10 positive regulation of glial cell proliferation GO:0060252 9.63 IL6 TNF
11 hemostasis GO:0007599 9.63 F2 F3 SERPINC1
12 regulation of signaling receptor activity GO:0010469 9.63 CD40LG F2 IFNG IL10 IL6 TNF
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG TNF
14 negative regulation of growth of symbiont in host GO:0044130 9.62 IL10 TNF
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
16 regulation of blood coagulation GO:0030193 9.59 F2 SERPINC1
17 response to molecule of bacterial origin GO:0002237 9.58 B2M IL10
18 negative regulation of lipid storage GO:0010888 9.56 IL6 TNF
19 endothelial cell apoptotic process GO:0072577 9.55 IL10 TNF
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 IL10 TNF
21 positive regulation of neuroinflammatory response GO:0150078 9.49 IL6 TNF
22 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
24 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
25 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
26 positive regulation of T cell proliferation GO:0042102 9.26 CD209 CD40LG IL6 TFRC
27 immune response GO:0006955 9.17 B2M CD40LG HLA-DRB1 IFNG IL10 IL6

Molecular functions related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 F3 SERPINC1 TNF
2 virus receptor activity GO:0001618 9.13 CD209 HLA-DRB1 TFRC
3 cytokine activity GO:0005125 9.02 CD40LG IFNG IL10 IL6 TNF

Sources for Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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