MCID: HMR012
MIFTS: 60

Hemorrhagic Fever

Categories: Genetic diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Hemorrhagic Fever

Summaries for Hemorrhagic Fever

MedlinePlus : 44 Viral hemorrhagic fevers (VHFs) are a group of illnesses caused by four families of viruses. These include the Ebola and Marburg, Lassa fever, and yellow fever viruses. VHFs have common features: they affect many organs, they damage the blood vessels, and they affect the body's ability to regulate itself. Some VHFs cause mild disease, but some, like Ebola or Marburg, cause severe disease and death. VHFs are found around the world. Specific diseases are usually limited to areas where the animals that carry them live. For example, Lassa fever is limited to rural areas of West Africa where rats and mice carry the virus. The risk for travelers is low, but you should avoid visiting areas where there are disease outbreaks. Because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism. Centers for Disease Control and Prevention

MalaCards based summary : Hemorrhagic Fever, also known as hemorrhagic fevers, viral, is related to marburg hemorrhagic fever and hemorrhagic fever with renal syndrome, and has symptoms including fever and pruritus. An important gene associated with Hemorrhagic Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ketotifen and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and t cells, and related phenotypes are cardiovascular system and homeostasis/metabolism

CDC : 3 VHFs are caused by viruses of four distinct families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. Each of these families share a number of features:

Related Diseases for Hemorrhagic Fever

Diseases in the Hemorrhagic Fever family:

Viral Hemorrhagic Fever

Diseases related to Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 424)
# Related Disease Score Top Affiliating Genes
1 marburg hemorrhagic fever 33.9 CD209 F2 TNF
2 hemorrhagic fever with renal syndrome 32.7 ALB B2M HLA-DRB1 IL6 ITGB3 TFRC
3 dengue hemorrhagic fever 32.2 ALB CD209 F2 HLA-DRB1 IFNG IL10
4 dengue shock syndrome 31.0 HLA-DRB1 IL6 TNF
5 tick-borne encephalitis 30.2 ALB CD209 IL10
6 myocarditis 30.1 CD40LG IL6 TNF
7 severe acute respiratory syndrome 30.0 CD209 IFNG TNF
8 hemophagocytic lymphohistiocytosis 30.0 B2M IFNG IL10 TNF
9 scrub typhus 29.9 GPT IL10 TNF
10 acute liver failure 29.9 ALB F2 GPT
11 cholecystitis 29.8 ALB F2 GPT
12 chlamydia 29.6 IFNG IL10 IL6 TNF
13 leishmaniasis 29.6 HLA-DRB1 IFNG IL10 TNF
14 infantile liver failure syndrome 1 29.5 ALB F2 GPT
15 pneumonia 29.5 CD40LG IL10 IL6 TNF
16 brucellosis 29.4 CD40LG IFNG IL10 IL6 TNF
17 leptospirosis 29.4 F2 IFNG IL10 IL6 TNF
18 visceral leishmaniasis 29.3 ALB IFNG IL10 TNF
19 appendicitis 29.3 ALB IL10 IL6 TNF
20 arthritis 29.3 HLA-DRB1 IFNG IL10 IL6 TNF
21 kawasaki disease 29.3 ALB IL10 IL6 TNF
22 compartment syndrome 29.2 ALB F2 TNF
23 filariasis 29.1 ALB IFNG IL10 IL6 TNF
24 purpura 29.0 F2 IL6 ITGB3 SERPINC1 TNF
25 acquired immunodeficiency syndrome 28.7 ALB B2M IFNG IL10 IL6 TNF
26 hepatitis b 28.7 ALB F2 GPT IFNG TNF
27 typhoid fever 28.7 ALB F2 IFNG IL6 TNF
28 hepatitis a 28.5 ALB F2 GPT IFNG IL10 TNF
29 peritonitis 28.3 ALB B2M F2 IL10 IL6 TNF
30 malaria 28.1 ALB CD40LG HLA-DRB1 IFNG IL10 IL6
31 vascular disease 28.1 ALB F2 IL6 ITGB3 SERPINC1 TNF
32 myocardial infarction 27.4 ALB CD40LG F2 IL10 IL6 ITGB3
33 crimean-congo hemorrhagic fever 12.8
34 omsk hemorrhagic fever 12.7
35 argentine hemorrhagic fever 12.7
36 ebola hemorrhagic fever 12.7
37 bolivian hemorrhagic fever 12.6
38 venezuelan hemorrhagic fever 12.6
39 alkhurma hemorrhagic fever 12.6
40 lujo hemorrhagic fever 12.6
41 korean hemorrhagic fever 12.6
42 viral hemorrhagic fever 12.5
43 brazilian hemorrhagic fever 12.5
44 chapare hemorrhagic fever 12.5
45 whitewater arroyo hemorrhagic fever 12.4
46 balkan hemorrhagic fever 12.4
47 dengue disease 12.2
48 lassa fever 11.9
49 kyasanur forest disease 11.9
50 dengue virus 11.4

Graphical network of the top 20 diseases related to Hemorrhagic Fever:



Diseases related to Hemorrhagic Fever

Symptoms & Phenotypes for Hemorrhagic Fever

UMLS symptoms related to Hemorrhagic Fever:


fever, pruritus

MGI Mouse Phenotypes related to Hemorrhagic Fever:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 B2M CD40LG F2 IFNG IL10 IL6
2 homeostasis/metabolism MP:0005376 10.24 ALB B2M CD40LG F2 IFNG IL10
3 hematopoietic system MP:0005397 10.21 B2M CD40LG F2 IFNG IL10 IL6
4 cellular MP:0005384 10.2 ALB B2M CD40LG IFNG IL10 IL6
5 digestive/alimentary MP:0005381 10.19 ALB B2M F2 IFNG IL10 IL6
6 immune system MP:0005387 10.18 B2M CD40LG F2 IFNG IL10 IL6
7 mortality/aging MP:0010768 10.14 ALB B2M CD40LG F2 IFNG IL10
8 integument MP:0010771 10.11 B2M CD40LG F2 IFNG IL10 IL6
9 liver/biliary system MP:0005370 10.09 ALB B2M IFNG IL10 IL6 ITGB3
10 embryo MP:0005380 10.07 F2 IFNG IL10 ITGB3 SERPINC1 TFRC
11 nervous system MP:0003631 10.02 B2M CD40LG F2 IFNG IL10 IL6
12 neoplasm MP:0002006 9.91 ALB B2M IFNG IL10 IL6 ITGB3
13 reproductive system MP:0005389 9.81 B2M CD40LG F2 IFNG IL10 IL6
14 renal/urinary system MP:0005367 9.73 ALB CD40LG IFNG IL6 ITGB3 SERPINC1
15 respiratory system MP:0005388 9.43 F2 IFNG IL10 IL6 ITGB3 TNF
16 skeleton MP:0005390 9.23 CD40LG F2 GPT IFNG IL10 IL6

Drugs & Therapeutics for Hemorrhagic Fever

Drugs for Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 125)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
2
Histamine Approved, Investigational Phase 4 51-45-6 774
3
tannic acid Approved Phase 4,Phase 1,Phase 2 1401-55-4
4
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2 94-09-7, 1994-09-7 2337
5
Histamine Phosphate Phase 4 51-74-1 65513
6 Anti-Allergic Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Histamine H1 Antagonists Phase 4
9 Antipruritics Phase 4
10 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Histamine Antagonists Phase 4
12 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
13 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Vasoconstrictor Agents Phase 4
15
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 6474909
16
Coal tar Approved Phase 2, Phase 3,Phase 1 8007-45-2
17
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
19
Lactitol Investigational Phase 3 585-86-4, 585-88-6 493591
20 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Not Applicable
21 Antiparasitic Agents Phase 2, Phase 3,Phase 1
22 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
23 Protective Agents Phase 3,Phase 1
24 DEET Phase 3
25 Insect Repellents Phase 3
26 Antibodies Phase 3,Phase 1,Phase 2,Not Applicable
27 Immunoglobulins Phase 3,Phase 1,Phase 2,Not Applicable
28 Antibodies, Blocking Phase 3
29 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
30 polysaccharide-K Phase 3,Phase 2,Phase 1
31 Vitamins Phase 3,Phase 2
32 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
33 Keratolytic Agents Phase 2, Phase 3,Phase 1
34 Iron-Dextran Complex Phase 3
35 Nutrients Phase 3
36 retinol Phase 3
37 Trace Elements Phase 3
38 Antioxidants Phase 3
39 Retinol palmitate Phase 3
40 Micronutrients Phase 3
41
Ribavirin Approved Phase 2,Not Applicable 36791-04-5 37542
42
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
43
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
44
Azithromycin Approved Phase 1, Phase 2 83905-01-5 55185 447043
45
Sunitinib Approved, Investigational Phase 1, Phase 2 557795-19-4, 341031-54-7 5329102
46
Irbesartan Approved, Investigational Phase 1, Phase 2 138402-11-6 3749
47
Angiotensin II Approved, Investigational Phase 1, Phase 2 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
48
Atorvastatin Approved Phase 1, Phase 2 134523-00-5 60823
49
chloroquine Approved, Investigational, Vet_approved Phase 1, Phase 2 54-05-7 2719
50
Artemether Approved Phase 2 71963-77-4 119380 68911

Interventional clinical trials:

(show top 50) (show all 278)
# Name Status NCT ID Phase Drugs
1 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
2 High Frequency Ventilation During Off Pump Coronary Artery Bypass Graft (CABG) Completed NCT00863044 Phase 4
3 Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines Recruiting NCT03368495 Phase 4
4 Immunogenicity and Safety of the Yellow Fever Vaccine in HIV Infected Individuals Recruiting NCT03132311 Phase 4
5 Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines (YEFE) Recruiting NCT02991495 Phase 4
6 International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-Combi Active, not recruiting NCT03072030 Phase 4
7 Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study) Active, not recruiting NCT02555072 Phase 4
8 Immunogenicity of Fractional One-fifth and One-half Doses of Yellow Fever Vaccine Compared to Full Dose in Children 9-23 Months Old Not yet recruiting NCT03725618 Phase 4
9 Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) Unknown status NCT00966628 Phase 3 Hypertonic sodium lactate;Ringer's lactate
10 Efficacy and Safety of Ivermectin Against Dengue Infection Unknown status NCT02045069 Phase 2, Phase 3 2 days Ivermectin;3 days Ivermectin;Placebo
11 Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR Unknown status NCT00938379 Phase 3 20% deet insect repellent;placebo control
12 STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) Completed NCT02378753 Phase 2, Phase 3
13 Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia Completed NCT01254422 Phase 3
14 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
15 Emergency Evaluation of Convalescent Plasma for Ebola Viral Disease (EVD) in Guinea Completed NCT02342171 Phase 2, Phase 3
16 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed NCT01411241 Phase 3
17 Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia Completed NCT01134263 Phase 3
18 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Completed NCT01373281 Phase 3
19 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Completed NCT01374516 Phase 3
20 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed NCT01436396 Phase 3
21 Evaluation of the Safety and Immunogenicity of Three Consistency Lots and a High-Dose Lot of rVSV-ZEBOV-GP (V920 Ebola Vaccine) in Healthy Adults (V920-012) Completed NCT02503202 Phase 3
22 Providing Additional Information on the Safety and Effectiveness of an Ebola Vaccine Completed NCT03161366 Phase 3
23 Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue Completed NCT03423173 Phase 3
24 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) in Adolescents in Non-Endemic Area(s) Completed NCT03341637 Phase 3
25 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
26 The Yellow Fever Vaccine Immunity in HIV Infected Patients : Development of New Assays for Virological and Immunological Monitoring in HIV Infected Patient. Completed NCT01426243 Phase 3
27 Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo Recruiting NCT02661464 Phase 3
28 Investigational Therapeutics for the Treatment of People With Ebola Virus Disease Recruiting NCT03719586 Phase 2, Phase 3 ZMapp;Remdesivir;MAb114;REGN-EB3
29 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Administered With a Yellow Fever Vaccine in Adults Recruiting NCT03342898 Phase 3
30 Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine Recruiting NCT02406729 Phase 3
31 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Active, not recruiting NCT02992418 Phase 3
32 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Gardasil® Active, not recruiting NCT02993757 Phase 3
33 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Cervarix® Active, not recruiting NCT02979535 Phase 3
34 Staged Phase 3 Study to Assess the Safety and Immunogenicity of Ebola Candidate Vaccines Ad26.ZEBOV and MVA-BN-Filo During Implementation of Stages 1 and 2 Active, not recruiting NCT02509494 Phase 3
35 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Co-administered With an Hepatitis A Virus Vaccine Active, not recruiting NCT03525119 Phase 3
36 Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine. Active, not recruiting NCT02699099 Phase 3
37 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) at the End of Shelf Life in Healthy Adults Not yet recruiting NCT03771963 Phase 3
38 Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola) Withdrawn NCT02307591 Phase 2, Phase 3 Best Supportive Care;Best Supportive Care + Amiodarone
39 Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms Unknown status NCT01973855 Phase 2 Western Medicine;TCM and Western Medicine
40 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2 Ribavirin
41 Multiple Treatments for Ebola Virus Disease (EVD) Unknown status NCT02380625 Phase 1, Phase 2 Azithromycin;Sunitinib and Erlotinib;Atorvastatin and Irbesartan
42 The Effect of Chloroquine in the Treatment of Patients With Dengue Unknown status NCT00849602 Phase 1, Phase 2 Placebo;Chloroquine
43 Activated Recombinant Human Factor VII in Patients With Dengue Haemorrhagic Fever Completed NCT01601613 Phase 2 activated recombinant human factor VII;placebo
44 Safety, Tolerability and Immunogenicity Study of 2 Prime-boost Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo Completed NCT02598388 Phase 2
45 Safety, Tolerability and Immunogenicity Study of 3 Prime-boost Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo in Healthy Adults, Children and Human Immunodeficiency Virus Positive (HIV+) Adults Completed NCT02564523 Phase 2
46 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed NCT01187433 Phase 2
47 A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines Completed NCT01064141 Phase 2
48 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed NCT00617344 Phase 2
49 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed NCT01550289 Phase 2
50 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2

Search NIH Clinical Center for Hemorrhagic Fever

Genetic Tests for Hemorrhagic Fever

Anatomical Context for Hemorrhagic Fever

MalaCards organs/tissues related to Hemorrhagic Fever:

42
Testes, Endothelial, T Cells, Kidney, Liver, Monocytes, Pituitary

Publications for Hemorrhagic Fever

Articles related to Hemorrhagic Fever:

(show top 50) (show all 2392)
# Title Authors Year
1
Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea. ( 30915955 )
2019
2
Genetic diversity of Alkhurma hemorrhagic fever virus in Western Asia. ( 30779959 )
2019
3
Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever. ( 30465883 )
2019
4
An Emerging Biothreat: Crimean-Congo Hemorrhagic Fever Virus in Southern and Western Asia. ( 30652673 )
2019
5
Co-Delivery Effect of CD24 on the Immunogenicity and Lethal Challenge Protection of a DNA Vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus. ( 30658445 )
2019
6
Crimean-Congo hemorrhagic fever and expansion from endemic regions. ( 30660091 )
2019
7
Crimean-Congo Hemorrhagic Fever, Kosovo, 2013-2016. ( 30666932 )
2019
8
Crimean Congo hemorrhagic fever serosurvey in humans for identifying high-risk populations and high-risk areas in the endemic state of Gujarat, India. ( 30709372 )
2019
9
Immunoglobulin-like Domain of HsFcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies. ( 30709812 )
2019
10
Crimean Congo hemorrhagic fever virus nucleocapsid protein harbors distinct RNA binding sites in the stalk and head domains. ( 30723154 )
2019
11
Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR-/- Mice Models. ( 30857305 )
2019
12
Apoptosis and its relation with clinical course in patients with crimean-congo hemorrhagic fever. ( 30905066 )
2019
13
The pulmonary findings of Crimean-Congo hemorrhagic fever patients with chest X-ray assessments. ( 30911987 )
2019
14
Increased Carotid Intima-Media Thickness in Children with a History of Dengue Hemorrhagic Fever. ( 30675845 )
2019
15
The effectiveness of health education using audiovisual media on increasing family behavior in preventing dengue hemorrhagic fever (DHF). ( 30745163 )
2019
16
Genome-wide profiling of mRNA and lncRNA expression in dengue fever and dengue hemorrhagic fever. ( 30868055 )
2019
17
Aeromedical Transfer of Patients with Viral Hemorrhagic Fever. ( 30431424 )
2019
18
Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis. ( 30650570 )
2019
19
Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. ( 30735719 )
2019
20
Epidemiologic study on changes in occurrence of hemorrhagic fever with renal syndrome in Republic of Korea for 17 years according to age group: 2001-2017. ( 30760218 )
2019
21
Effects of climate factors on hemorrhagic fever with renal syndrome in Changchun, 2013 to 2017. ( 30817583 )
2019
22
Transmission routes of the virus causing viral hemorrhagic fever: Extreme precautions are prudent but high-quality evidence must be gathered. ( 30895919 )
2019
23
Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea. ( 30914905 )
2019
24
Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report. ( 29508304 )
2018
25
Second International Conference on Crimean-Congo Hemorrhagic Fever. ( 29199036 )
2018
26
Lethal infection of embryonated chicken eggs by Hazara virus, a model for Crimean-Congo hemorrhagic fever virus. ( 29030708 )
2018
27
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome. ( 29450213 )
2018
28
Impact of meteorological factors on hemorrhagic fever with renal syndrome in 19 cities in China, 2005-2014. ( 29913587 )
2018
29
Notes from the Field: Crimean-Congo Hemorrhagic Fever Outbreak - Central Uganda, August-September 2017. ( 29879093 )
2018
30
Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China. ( 29524182 )
2018
31
Meteorological factors and risk of hemorrhagic fever with renal syndrome in Guangzhou, southern China, 2006-2015. ( 29949572 )
2018
32
Analysis of codon usage bias of Crimean-Congo hemorrhagic fever virus and its adaptation to hosts. ( 29198972 )
2018
33
Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor. ( 29664386 )
2018
34
Structure-Function Assays for Crimean-Congo Hemorrhagic Fever Virus Polymerase. ( 28986838 )
2018
35
Platelet Count, D-Dimer, Component Therapy and Dengue Hemorrhagic Fever. ( 29622891 )
2018
36
Climate variability and dengue hemorrhagic fever in Southeast Sulawesi Province, Indonesia. ( 29549613 )
2018
37
Seroepidemiologic Survey of Crimean-Congo Hemorrhagic Fever Virus in Selected Risk Groups, South Africa. ( 29912704 )
2018
38
Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in I1-capture and IgG immune complex (IC) ELISA tests. ( 29579040 )
2018
39
Isolation and whole-genome sequencing of a Crimean-Congo hemorrhagic fever virus strain, Greece. ( 29525552 )
2018
40
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. ( 29760382 )
2018
41
Delayed Interferon Type 1-Induced Antiviral State Is a Potential Factor for Hemorrhagic Fever With Renal Syndrome Severity. ( 29281106 )
2018
42
Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29335595 )
2018
43
Murine Models for Viral Hemorrhagic Fever. ( 28986841 )
2018
44
A Primate Model for Viral Hemorrhagic Fever. ( 28986843 )
2018
45
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. ( 29319426 )
2018
46
A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies. ( 29330092 )
2018
47
Absence of a Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Yeoncheon Compared to Nationwide Korea. ( 29968979 )
2018
48
Prospective forecasts of annual dengue hemorrhagic fever incidence in Thailand, 2010-2014. ( 29463757 )
2018
49
Crimean-Congo hemorrhagic fever with hepatic impairment and vaginal hemorrhage: a case report. ( 29724249 )
2018
50
Phylodynamics of Crimean Congo hemorrhagic fever virus in South Russia. ( 29413882 )
2018

Variations for Hemorrhagic Fever

Expression for Hemorrhagic Fever

Search GEO for disease gene expression data for Hemorrhagic Fever.

Pathways for Hemorrhagic Fever

Pathways related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 B2M CD209 CD40LG HLA-DRB1 IFNG IL10
2
Show member pathways
13.24 B2M CD40LG HLA-DRB1 IFNG IL10 IL6
3
Show member pathways
12.74 B2M CD40LG HLA-DRB1 IFNG IL10 IL6
4
Show member pathways
12.58 CD40LG HLA-DRB1 IFNG IL10 TNF
5
Show member pathways
12.54 HLA-DRB1 IFNG IL10 IL6 TNF
6
Show member pathways
12.53 CD209 HLA-DRB1 IFNG IL6 TNF
7
Show member pathways
12.53 F2 IFNG IL10 IL6 TNF
8 12.49 B2M CD40LG IFNG IL10 TNF
9
Show member pathways
12.35 CD40LG IFNG IL10 IL6 TNF
10
Show member pathways
12.24 ALB F2 IFNG IL6 TNF
11
Show member pathways
12.19 IFNG IL10 IL6 TNF
12
Show member pathways
12.17 CD209 IL10 IL6 TNF
13
Show member pathways
12.16 CD40LG HLA-DRB1 IFNG IL10 TNF
14 12.1 CD209 HLA-DRB1 ITGB3 TFRC
15 12.05 CD209 HLA-DRB1 IFNG IL10 IL6 TNF
16 12.02 IFNG ITGB3 TNF
17
Show member pathways
12 IFNG IL10 IL6 TNF
18 11.98 IFNG ITGB3 TNF
19
Show member pathways
11.97 F2 IFNG IL6 TNF
20 11.95 IFNG IL6 TNF
21 11.92 IL10 IL6 TNF
22
Show member pathways
11.91 B2M HLA-DRB1 IFNG
23 11.85 IFNG IL6 TFRC
24 11.84 IFNG IL10 IL6 TNF
25 11.81 IFNG IL10 IL6
26 11.8 HLA-DRB1 IFNG IL6 TNF
27 11.79 HLA-DRB1 IL6 ITGB3 TFRC TNF
28 11.75 IFNG IL10 TNF
29
Show member pathways
11.73 CD40LG IFNG TNF
30 11.73 IL10 IL6 TNF
31 11.64 CD40LG IL10 ITGB3
32 11.64 CD209 IFNG IL10 IL6 TNF
33
Show member pathways
11.62 B2M IFNG TNF
34
Show member pathways
11.58 CD40LG IFNG IL6 TNF
35 11.53 IFNG IL6 TNF
36 11.51 IL10 IL6 TNF
37 11.51 IFNG IL10 IL6 ITGB3 TNF
38 11.5 CD209 IFNG IL10 IL6 ITGB3 TNF
39 11.47 IFNG IL6 TNF
40 11.45 ALB F2 TFRC
41 11.33 IL10 IL6 TNF
42 11.3 IFNG IL10 IL6 TNF
43 11.27 IFNG IL6 TNF
44 11.24 CD40LG IFNG IL10 IL6 TNF
45 11.18 CD40LG IL10 IL6 TNF
46 10.98 IL6 TNF
47 10.97 CD40LG IL10 IL6 ITGB3 TNF
48 10.48 HLA-DRB1 IFNG IL10 IL6 TNF

GO Terms for Hemorrhagic Fever

Cellular components related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ALB B2M CD209 CD40LG F2 IFNG
2 cell surface GO:0009986 9.8 B2M CD209 CD40LG HLA-DRB1 ITGB3 TFRC
3 endoplasmic reticulum lumen GO:0005788 9.72 ALB B2M F2 IL6 SERPINC1
4 blood microparticle GO:0072562 9.67 ALB F2 SERPINC1 TFRC
5 external side of plasma membrane GO:0009897 9.5 B2M CD209 CD40LG F2 HLA-DRB1 TFRC
6 HFE-transferrin receptor complex GO:1990712 9.43 B2M TFRC
7 extracellular space GO:0005615 9.36 ALB B2M CD40LG F2 GPT IFNG
8 extracellular exosome GO:0070062 10.01 ALB B2M F2 GPT HLA-DRB1 ITGB3

Biological processes related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CD40LG IL10 IL6 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.8 F2 IFNG ITGB3 TNF
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 IL10 IL6 TNF
4 interferon-gamma-mediated signaling pathway GO:0060333 9.74 B2M HLA-DRB1 IFNG
5 response to glucocorticoid GO:0051384 9.73 IL10 IL6 TNF
6 regulation of signaling receptor activity GO:0010469 9.73 CD40LG F2 IFNG IL10 IL6 TNF
7 cellular protein metabolic process GO:0044267 9.72 ALB B2M F2 IL6 SERPINC1
8 platelet activation GO:0030168 9.71 CD40LG F2 IL6 ITGB3
9 humoral immune response GO:0006959 9.7 IFNG IL6 TNF
10 viral entry into host cell GO:0046718 9.67 CD209 HLA-DRB1 ITGB3 TFRC
11 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
12 positive regulation of glial cell proliferation GO:0060252 9.62 IL6 TNF
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG TNF
14 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
16 regulation of blood coagulation GO:0030193 9.59 F2 SERPINC1
17 response to molecule of bacterial origin GO:0002237 9.58 B2M IL10
18 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 IL10 TNF
20 positive regulation of neuroinflammatory response GO:0150078 9.54 IL6 TNF
21 regulation of immunoglobulin secretion GO:0051023 9.51 CD40LG TNF
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG TNF
23 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
24 positive regulation of T cell proliferation GO:0042102 9.46 CD209 CD40LG IL6 TFRC
25 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 IFNG TNF
26 immune response GO:0006955 9.17 B2M CD40LG HLA-DRB1 IFNG IL10 IL6
27 negative regulation of lipid storage GO:0010888 9.13 IL6 ITGB3 TNF

Molecular functions related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 ALB B2M ITGB3 SERPINC1 TFRC TNF
2 protease binding GO:0002020 9.43 ITGB3 SERPINC1 TNF
3 virus receptor activity GO:0001618 9.26 CD209 HLA-DRB1 ITGB3 TFRC
4 cytokine activity GO:0005125 9.02 CD40LG IFNG IL10 IL6 TNF

Sources for Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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