MCID: HMR046
MIFTS: 29

Hemorrhagic Fever-Renal Syndrome

Categories: Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Hemorrhagic Fever-Renal Syndrome

MalaCards integrated aliases for Hemorrhagic Fever-Renal Syndrome:

Name: Hemorrhagic Fever-Renal Syndrome 58
Hantavirus Fever 58
Hantavirosis 58

Characteristics:

Orphanet epidemiological data:

58
hemorrhagic fever-renal syndrome
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Hemorrhagic Fever-Renal Syndrome

MalaCards based summary : Hemorrhagic Fever-Renal Syndrome, also known as hantavirus fever, is related to korean hemorrhagic fever and viral pneumonia. An important gene associated with Hemorrhagic Fever-Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Immune response NFAT in immune response and NF-kappaB Signaling. Affiliated tissues include brain, and related phenotypes are fatigue and fever

Related Diseases for Hemorrhagic Fever-Renal Syndrome

Diseases related to Hemorrhagic Fever-Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 korean hemorrhagic fever 10.0
2 viral pneumonia 10.0
3 hantavirus hemorrhagic fever with renal syndrome 10.0
4 pulmonary edema 10.0
5 crimean-congo hemorrhagic fever 10.0
6 hantavirus pulmonary syndrome 10.0
7 leptospirosis 10.0
8 c1q nephropathy 9.8 CD79A CD40LG
9 hilar lung carcinoma 9.8 CD79A CD40LG
10 lung hilum cancer 9.8 CD79A CD40LG
11 immunoglobulin g deficiency 9.8 CD79A CD40LG
12 cryofibrinogenemia 9.8 CD79A CD40LG
13 monoclonal paraproteinemia 9.8 CD79A CD40LG
14 ocular toxoplasmosis 9.8 CD79A CD40LG
15 toxoplasmosis 9.8 CD79A CD40LG
16 cerebral lymphoma 9.8 CD79A CD40LG
17 selective igg deficiency disease 9.8 CD79A CD40LG
18 alpha chain disease 9.8 CD79A CD40LG
19 congenital syphilis 9.8 CD79A CD40LG
20 syphilis 9.8 CD79A CD40LG
21 anisakiasis 9.8 CD79A CD40LG
22 secondary syphilis 9.8 CD79A CD40LG
23 heavy chain disease 9.8 CD79A CD40LG
24 immunoglobulin a deficiency 1 9.8 CD79A CD40LG
25 pustulosis palmaris et plantaris 9.8 CD79A CD40LG
26 parotitis 9.8 CD79A CD40LG
27 calciphylaxis 9.8 CD79A CD40LG
28 pleural empyema 9.8 CD79A CD40LG
29 sporotrichosis 9.8 CD79A CD40LG
30 dysgammaglobulinemia 9.8 CD79A CD40LG
31 waldenstroem's macroglobulinemia 9.8 CD79A CD40LG
32 acute poststreptococcal glomerulonephritis 9.8 CD79A CD40LG
33 glomerulonephritis 9.8 CD79A CD40LG
34 congenital toxoplasmosis 9.8 CD79A CD40LG
35 persistent generalized lymphadenopathy 9.8 CD79A CD40LG
36 spleen cancer 9.8 CD79A CD40LG
37 giardiasis 9.8 CD79A CD40LG
38 henoch-schoenlein purpura 9.8 CD79A CD40LG
39 purpura 9.8 CD79A CD40LG
40 hypersensitivity reaction type iii disease 9.8 CD79A CD40LG
41 amebiasis 9.8 CD79A CD40LG
42 mesangial proliferative glomerulonephritis 9.8 CD79A CD40LG
43 cryptosporidiosis 9.8 CD79A CD40LG
44 immunoglobulin alpha deficiency 9.8 CD79A CD40LG
45 bacteriuria 9.8 CD79A CD40LG
46 protein-losing enteropathy 9.8 CD79A CD40LG
47 lipoid nephrosis 9.8 CD79A CD40LG
48 immunodeficiency with hyper-igm, type 1 9.8 CD79A CD40LG
49 guillain-barre syndrome 9.8 CD79A CD40LG
50 dermatitis herpetiformis 9.8 CD79A CD40LG

Graphical network of the top 20 diseases related to Hemorrhagic Fever-Renal Syndrome:



Diseases related to Hemorrhagic Fever-Renal Syndrome

Symptoms & Phenotypes for Hemorrhagic Fever-Renal Syndrome

Human phenotypes related to Hemorrhagic Fever-Renal Syndrome:

58 31 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 proteinuria 58 31 frequent (33%) Frequent (79-30%) HP:0000093
4 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
5 renal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0000083
6 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
7 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
8 pulmonary infiltrates 58 31 frequent (33%) Frequent (79-30%) HP:0002113
9 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
10 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
11 respiratory insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002093
12 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
13 atelectasis 58 31 frequent (33%) Frequent (79-30%) HP:0100750
14 migraine 58 31 frequent (33%) Frequent (79-30%) HP:0002076
15 conjunctivitis 58 31 frequent (33%) Frequent (79-30%) HP:0000509
16 pleural effusion 58 31 frequent (33%) Frequent (79-30%) HP:0002202
17 oliguria 58 31 frequent (33%) Frequent (79-30%) HP:0100520
18 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
19 hypoproteinemia 58 31 frequent (33%) Frequent (79-30%) HP:0003075
20 subconjunctival hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0011896
21 abnormal tubulointerstitial morphology 31 frequent (33%) HP:0001969
22 arrhythmia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011675
23 abnormal myocardium morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001637
24 abnormal pericardium morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001697
25 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
26 hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0000822
27 myopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000545
28 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
29 intracranial hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002170
30 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
31 amaurosis fugax 58 31 occasional (7.5%) Occasional (29-5%) HP:0100576
32 abnormality of the renal tubule 58 Frequent (79-30%)
33 tubulointerstitial abnormality 58 Frequent (79-30%)

Drugs & Therapeutics for Hemorrhagic Fever-Renal Syndrome

Search Clinical Trials , NIH Clinical Center for Hemorrhagic Fever-Renal Syndrome

Genetic Tests for Hemorrhagic Fever-Renal Syndrome

Anatomical Context for Hemorrhagic Fever-Renal Syndrome

MalaCards organs/tissues related to Hemorrhagic Fever-Renal Syndrome:

40
Brain

Publications for Hemorrhagic Fever-Renal Syndrome

Articles related to Hemorrhagic Fever-Renal Syndrome:

(show all 26)
# Title Authors PMID Year
1
Sociocultural determinants of adoption of preventive practices for hantavirus: A knowledge, attitudes, and practices survey in Tonosí, Panama. 61
32107494 2020
2
Characterization of Biomarker Levels in Crimean-Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome. 61
31357521 2019
3
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. 61
27943332 2017
4
'Bedside assessment' of acute hantavirus infections and their possible classification into the spectrum of haemophagocytic syndromes. 61
27101352 2016
5
Serological survey of Seewis virus antibodies in patients suspected for hantavirus infection in Finland; a cross-reaction between Puumala virus antiserum with Seewis virus N protein? 61
25787939 2015
6
Animal models for some important RNA viruses of public health concern in SEARO countries: viral hemorrhagic fever. 61
25815861 2015
7
Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain. 61
24937036 2014
8
Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained? 61
24440318 2014
9
Hantavirus fever without pulmonary syndrome in Panama. 61
23836565 2013
10
[Study on hemorrhagic fever renal syndrome from 1983-2003 in Zibo, Shandong province]. 61
17649702 2007
11
[Surveillance on hemorrhagic fever renal syndrome from 1995 to 2004 in Jinan]. 61
17343192 2006
12
[Serological surveillance on vaccine against hemorrhagic fever with renal syndrome]. 61
15231163 2004
13
[Using recombinant antigens of Hantavirus to study the kinetics of serum IgA, IgG, IgM antibodies in the acute-phase of hemorrhagic fever renal syndrome]. 61
15340571 2003
14
[Serum antibody response and Hantavirus RNA sequencing in patients with hemorrhagic fever renal syndrome in Yantai areas]. 61
12869991 2003
15
[Study on using colloidal gold immuno-dot assay to detect special antibody of hemorrhagic fever renal syndrome]. 61
12575393 2001
16
[Hemorrhagic fever renal syndrome-associated virus]. 61
8650366 1996
17
[Structural protein of hemorrhagic fever renal syndrome virus in uric fusion cells in hemorrhagic fever renal syndrome]. 61
8100735 1993
18
[Sero-types in the hemorrhagic fever renal syndrome: I. An identification of sero-types of HFRS by hemagglutination inhibition assay]. 61
2874886 1986
19
[Main reservoirs of infection of the hemorrhagic fever renal syndrome in endemic areas of Anhui Province]. 61
2862997 1985
20
[Relationship between hosts and hemorrhagic fever renal syndrome in Chang-an County, Shan-xi Province]. 61
2862998 1985
21
[Morphological study of two strains of hemorrhagic fever renal syndrome virus isolated from patients]. 61
2861905 1985
22
[Distribution of rodents in an endemic area of hemorrhagic fever renal syndrome infection in Chen-qiao District, Ying-shang County, Anhui Province]. 61
2859925 1985
23
[Cases of hemorrhagic fever renal syndrome in 3 counties of the Guang Xi Zhuang Tribe Autonomous Region for the first time with the recovery of hemorrhagic fever viral agents from infected rodents]. 61
2859926 1985
24
[Survey on the reservior for hemorrhagic fever-renal syndrome in Yingshang County, Anhui Province]. 61
6146404 1984
25
[Survey on serum hemorrhagic fever-renal syndrome antibody in normal population of Zhenjiang Prefecture]. 61
6147237 1984
26
[Identification of hemorrhagic fever-renal syndrome virus isolated from different areas in China by immuno-enzyme electron microscopy--morphological study on various virulent strains]. 61
6233018 1983

Variations for Hemorrhagic Fever-Renal Syndrome

Expression for Hemorrhagic Fever-Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever-Renal Syndrome.

Pathways for Hemorrhagic Fever-Renal Syndrome

Pathways related to Hemorrhagic Fever-Renal Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CD79A CD40LG
2 11.47 CD79A CD40LG
3 10.2 CD79A CD40LG

GO Terms for Hemorrhagic Fever-Renal Syndrome

Cellular components related to Hemorrhagic Fever-Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD79A CD40LG

Biological processes related to Hemorrhagic Fever-Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD79A CD40LG
2 B cell proliferation GO:0042100 8.62 CD79A CD40LG

Sources for Hemorrhagic Fever-Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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