MCID: HMR046
MIFTS: 28

Hemorrhagic Fever-Renal Syndrome

Categories: Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Hemorrhagic Fever-Renal Syndrome

MalaCards integrated aliases for Hemorrhagic Fever-Renal Syndrome:

Name: Hemorrhagic Fever-Renal Syndrome 58
Hantavirus Fever 58
Hantavirosis 58

Characteristics:

Orphanet epidemiological data:

58
hemorrhagic fever-renal syndrome
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Hemorrhagic Fever-Renal Syndrome

MalaCards based summary : Hemorrhagic Fever-Renal Syndrome, also known as hantavirus fever, is related to korean hemorrhagic fever and hantavirus hemorrhagic fever with renal syndrome. An important gene associated with Hemorrhagic Fever-Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Immune response NFAT in immune response and NF-kappaB Signaling. Related phenotypes are fatigue and fever

Related Diseases for Hemorrhagic Fever-Renal Syndrome

Diseases related to Hemorrhagic Fever-Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 korean hemorrhagic fever 9.9
2 hantavirus hemorrhagic fever with renal syndrome 9.9
3 pulmonary edema 9.9
4 crimean-congo hemorrhagic fever 9.9
5 hantavirus pulmonary syndrome 9.9
6 leptospirosis 9.9
7 c1q nephropathy 9.9 CD79A CD40LG
8 cryofibrinogenemia 9.9 CD79A CD40LG
9 immunoglobulin g deficiency 9.9 CD79A CD40LG
10 ocular toxoplasmosis 9.9 CD79A CD40LG
11 toxoplasmosis 9.9 CD79A CD40LG
12 respiratory papillomatosis, juvenile recurrent, congenital 9.9 CD79A CD40LG
13 congenital syphilis 9.9 CD79A CD40LG
14 syphilis 9.9 CD79A CD40LG
15 secondary syphilis 9.8 CD79A CD40LG
16 immunoglobulin a deficiency 1 9.8 CD79A CD40LG
17 pustulosis palmaris et plantaris 9.8 CD79A CD40LG
18 calciphylaxis 9.8 CD79A CD40LG
19 sporotrichosis 9.8 CD79A CD40LG
20 congenital toxoplasmosis 9.8 CD79A CD40LG
21 persistent generalized lymphadenopathy 9.8 CD79A CD40LG
22 cryptosporidiosis 9.8 CD79A CD40LG
23 immunoglobulin alpha deficiency 9.8 CD79A CD40LG
24 lymphoplasmacytic lymphoma 9.8 CD79A CD40LG
25 bacteriuria 9.8 CD79A CD40LG
26 immunodeficiency with hyper-igm, type 1 9.8 CD79A CD40LG
27 cryoglobulinemia 9.8 CD79A CD40LG
28 meningoencephalitis 9.8 CD79A CD40LG
29 marginal zone b-cell lymphoma 9.8 CD79A CD40LG
30 agammaglobulinemia, x-linked 9.8 CD79A CD40LG
31 agammaglobulinemia 9.8 CD79A CD40LG
32 immunodeficiency-centromeric instability-facial anomalies syndrome 9.8 CD79A CD40LG
33 antiphospholipid syndrome 9.8 CD79A CD40LG
34 sjogren syndrome 9.8 CD79A CD40LG
35 iga glomerulonephritis 9.8 CD79A CD40LG
36 glomerulonephritis 9.8 CD79A CD40LG
37 tetanus 9.8 CD79A CD40LG
38 acquired immunodeficiency syndrome 9.8 CD79A CD40LG
39 vasculitis 9.7 CD79A CD40LG
40 chronic granulomatous disease 9.7 CD79A CD40LG
41 primary biliary cholangitis 9.7 CD79A CD40LG
42 common variable immunodeficiency 9.7 CD79A CD40LG
43 immune deficiency disease 9.7 CD79A CD40LG
44 autoimmune disease 9.6 CD79A CD40LG
45 leukemia, chronic lymphocytic 9.6 CD79A CD40LG
46 thrombocytopenia 9.5 CD79A CD40LG

Graphical network of the top 20 diseases related to Hemorrhagic Fever-Renal Syndrome:



Diseases related to Hemorrhagic Fever-Renal Syndrome

Symptoms & Phenotypes for Hemorrhagic Fever-Renal Syndrome

Human phenotypes related to Hemorrhagic Fever-Renal Syndrome:

58 31 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 respiratory insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002093
4 proteinuria 58 31 frequent (33%) Frequent (79-30%) HP:0000093
5 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
6 renal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0000083
7 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
8 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
9 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
10 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
11 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
12 atelectasis 58 31 frequent (33%) Frequent (79-30%) HP:0100750
13 migraine 58 31 frequent (33%) Frequent (79-30%) HP:0002076
14 conjunctivitis 58 31 frequent (33%) Frequent (79-30%) HP:0000509
15 pleural effusion 58 31 frequent (33%) Frequent (79-30%) HP:0002202
16 pulmonary infiltrates 58 31 frequent (33%) Frequent (79-30%) HP:0002113
17 oliguria 58 31 frequent (33%) Frequent (79-30%) HP:0100520
18 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
19 hypoproteinemia 58 31 frequent (33%) Frequent (79-30%) HP:0003075
20 subconjunctival hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0011896
21 abnormal tubulointerstitial morphology 31 frequent (33%) HP:0001969
22 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
23 hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0000822
24 myopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000545
25 abnormal myocardium morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001637
26 arrhythmia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011675
27 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
28 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
29 intracranial hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002170
30 abnormal pericardium morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001697
31 amaurosis fugax 58 31 occasional (7.5%) Occasional (29-5%) HP:0100576
32 abnormality of the renal tubule 58 Frequent (79-30%)
33 tubulointerstitial abnormality 58 Frequent (79-30%)

Drugs & Therapeutics for Hemorrhagic Fever-Renal Syndrome

Search Clinical Trials , NIH Clinical Center for Hemorrhagic Fever-Renal Syndrome

Genetic Tests for Hemorrhagic Fever-Renal Syndrome

Anatomical Context for Hemorrhagic Fever-Renal Syndrome

Publications for Hemorrhagic Fever-Renal Syndrome

Articles related to Hemorrhagic Fever-Renal Syndrome:

(show all 25)
# Title Authors PMID Year
1
Sociocultural determinants of adoption of preventive practices for hantavirus: A knowledge, attitudes, and practices survey in Tonosí, Panama. 61
32107494 2020
2
Characterization of Biomarker Levels in Crimean-Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome. 61
31357521 2019
3
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. 61
27943332 2017
4
'Bedside assessment' of acute hantavirus infections and their possible classification into the spectrum of haemophagocytic syndromes. 61
27101352 2016
5
Serological survey of Seewis virus antibodies in patients suspected for hantavirus infection in Finland; a cross-reaction between Puumala virus antiserum with Seewis virus N protein? 61
25787939 2015
6
Animal models for some important RNA viruses of public health concern in SEARO countries: viral hemorrhagic fever. 61
25815861 2015
7
Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain. 61
24937036 2014
8
Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained? 61
24440318 2014
9
Hantavirus fever without pulmonary syndrome in Panama. 61
23836565 2013
10
[Study on hemorrhagic fever renal syndrome from 1983-2003 in Zibo, Shandong province]. 61
17649702 2007
11
[Surveillance on hemorrhagic fever renal syndrome from 1995 to 2004 in Jinan]. 61
17343192 2006
12
[Serological surveillance on vaccine against hemorrhagic fever with renal syndrome]. 61
15231163 2004
13
[Using recombinant antigens of Hantavirus to study the kinetics of serum IgA, IgG, IgM antibodies in the acute-phase of hemorrhagic fever renal syndrome]. 61
15340571 2003
14
[Serum antibody response and Hantavirus RNA sequencing in patients with hemorrhagic fever renal syndrome in Yantai areas]. 61
12869991 2003
15
[Study on using colloidal gold immuno-dot assay to detect special antibody of hemorrhagic fever renal syndrome]. 61
12575393 2001
16
[Structural protein of hemorrhagic fever renal syndrome virus in uric fusion cells in hemorrhagic fever renal syndrome]. 61
8100735 1993
17
[Sero-types in the hemorrhagic fever renal syndrome: I. An identification of sero-types of HFRS by hemagglutination inhibition assay]. 61
2874886 1986
18
[Main reservoirs of infection of the hemorrhagic fever renal syndrome in endemic areas of Anhui Province]. 61
2862997 1985
19
[Relationship between hosts and hemorrhagic fever renal syndrome in Chang-an County, Shan-xi Province]. 61
2862998 1985
20
[Morphological study of two strains of hemorrhagic fever renal syndrome virus isolated from patients]. 61
2861905 1985
21
[Distribution of rodents in an endemic area of hemorrhagic fever renal syndrome infection in Chen-qiao District, Ying-shang County, Anhui Province]. 61
2859925 1985
22
[Cases of hemorrhagic fever renal syndrome in 3 counties of the Guang Xi Zhuang Tribe Autonomous Region for the first time with the recovery of hemorrhagic fever viral agents from infected rodents]. 61
2859926 1985
23
[Survey on the reservior for hemorrhagic fever-renal syndrome in Yingshang County, Anhui Province]. 61
6146404 1984
24
[Survey on serum hemorrhagic fever-renal syndrome antibody in normal population of Zhenjiang Prefecture]. 61
6147237 1984
25
[Identification of hemorrhagic fever-renal syndrome virus isolated from different areas in China by immuno-enzyme electron microscopy--morphological study on various virulent strains]. 61
6233018 1983

Variations for Hemorrhagic Fever-Renal Syndrome

Expression for Hemorrhagic Fever-Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever-Renal Syndrome.

Pathways for Hemorrhagic Fever-Renal Syndrome

Pathways related to Hemorrhagic Fever-Renal Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CD79A CD40LG
2 11.47 CD79A CD40LG
3 10.2 CD79A CD40LG

GO Terms for Hemorrhagic Fever-Renal Syndrome

Cellular components related to Hemorrhagic Fever-Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD79A CD40LG

Biological processes related to Hemorrhagic Fever-Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD79A CD40LG
2 B cell proliferation GO:0042100 8.62 CD79A CD40LG

Sources for Hemorrhagic Fever-Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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