HFRS
MCID: HMR004
MIFTS: 61

Hemorrhagic Fever with Renal Syndrome (HFRS)

Categories: Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

MalaCards integrated aliases for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 12 76 44 15 73
Hantavirosis 59 73
Hemorrhagic Fever-Renal Syndrome 59
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hantavirus Fever 59
Hfrs 12

Characteristics:

Orphanet epidemiological data:

59
hemorrhagic fever-renal syndrome
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to hemophagocytic lymphohistiocytosis and hemorrhagic fever. An important gene associated with Hemorrhagic Fever with Renal Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Antibodies, Blocking and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and t cells, and related phenotypes are hypertension and respiratory insufficiency

Wikipedia : 76 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis 32.4 B2M CXCL8 TNF
2 hemorrhagic fever 31.2 ALB B2M HLA-DRB1 IL6 TFRC TNF
3 viral infectious disease 30.7 CXCL8 IL6 TNF
4 acute pancreatitis 30.4 CRP CXCL8 IL6
5 leptospirosis 30.2 CRP CXCL8 IL6 TNF
6 acute respiratory distress syndrome 29.9 CXCL8 IL6 TNF
7 chlamydia 29.8 CRP CXCL8 IL6 TNF
8 myocardial infarction 29.8 ALB CRP IL6 ITGB3 TNF
9 myeloma, multiple 29.6 ALB B2M CRP CXCL8 IL6 TNF
10 korean hemorrhagic fever 12.1
11 danubian endemic familial nephropathy 11.5
12 hantavirus pulmonary syndrome 11.5
13 balkan hemorrhagic fever 11.1
14 aids dementia complex 10.3 B2M TNF
15 extramedullary plasmacytoma 10.3 B2M IL6
16 retinitis pigmentosa 55 10.3 IL6 TNF
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
18 critical limb ischemia 10.3 IL6 TNF
19 juvenile ankylosing spondylitis 10.3 IL6 TNF
20 glossitis 10.3 IL6 TNF
21 laryngitis 10.3 IL6 TNF
22 null-cell leukemia 10.3 IL6 TNF
23 leukomalacia 10.3 IL6 TNF
24 cardiogenic shock 10.3 IL6 TNF
25 burns 10.3 CRP TNF
26 melancholia 10.3 CRP TNF
27 neutrophilia, hereditary 10.3 CRP IL6
28 salpingitis 10.3 CRP TNF
29 sudden sensorineural hearing loss 10.3 IL6 ITGB3
30 acute cholangitis 10.3 CRP IL6
31 cold agglutinin disease 10.3 CRP IL6
32 cryopyrin-associated periodic syndrome 10.3 CRP IL6
33 uremic pruritus 10.3 CRP IL6
34 immunodeficiency 43 10.3 ALB B2M
35 macrophage activation syndrome 10.3 CD163 TNF
36 diffuse glomerulonephritis 10.3 ALB B2M
37 orthostatic proteinuria 10.3 ALB B2M
38 chronic graft versus host disease 10.3 ALB TNF
39 abdominal tuberculosis 10.3 ALB CRP
40 gastrointestinal tuberculosis 10.3 ALB CRP
41 decubitus ulcer 10.3 ALB CRP
42 beryllium disease 10.2 HLA-DRB1 TNF
43 chronic beryllium disease 10.2 HLA-DRB1 TNF
44 tungiasis 10.2 CXCL8 TNF
45 trichuriasis 10.2 CXCL8 TNF
46 cardiac sarcoidosis 10.2 CXCL8 TNF
47 opisthorchiasis 10.2 CXCL8 TNF
48 funisitis 10.2 CXCL8 IL6
49 recurrent corneal erosion 10.2 CXCL8 IL6
50 denture stomatitis 10.2 CXCL8 IL6

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hemorrhagic Fever with Renal Syndrome

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

59 32 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0000822
2 respiratory insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0002093
3 hypotension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002615
4 renal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0000083
5 proteinuria 59 32 frequent (33%) Frequent (79-30%) HP:0000093
6 photophobia 59 32 frequent (33%) Frequent (79-30%) HP:0000613
7 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
8 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
9 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
10 arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0011675
11 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
12 myopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000545
13 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
14 tubulointerstitial abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0001969
15 migraine 59 32 frequent (33%) Frequent (79-30%) HP:0002076
16 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
17 amaurosis fugax 59 32 occasional (7.5%) Occasional (29-5%) HP:0100576
18 abnormal myocardium morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0001637
19 hemoptysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002105
20 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
21 atelectasis 59 32 frequent (33%) Frequent (79-30%) HP:0100750
22 leukocytosis 59 32 frequent (33%) Frequent (79-30%) HP:0001974
23 conjunctivitis 59 32 frequent (33%) Frequent (79-30%) HP:0000509
24 intracranial hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002170
25 pleural effusion 59 32 frequent (33%) Frequent (79-30%) HP:0002202
26 pulmonary infiltrates 59 32 frequent (33%) Frequent (79-30%) HP:0002113
27 abnormal pericardium morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0001697
28 oliguria 59 32 frequent (33%) Frequent (79-30%) HP:0100520
29 hypoproteinemia 59 32 frequent (33%) Frequent (79-30%) HP:0003075
30 subconjunctival hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0011896
31 elevated hepatic transaminases 59 Frequent (79-30%)
32 abnormality of the renal tubule 59 Frequent (79-30%)
33 elevated hepatic transaminase 32 frequent (33%) HP:0002910

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 B2M CD163 CRP IL6 ITGB3 SEMA4D
2 hematopoietic system MP:0005397 9.91 B2M CD163 HLA-DRB5 IL6 ITGB3 SEMA4D
3 homeostasis/metabolism MP:0005376 9.85 ALB B2M CD163 CRP IL6 ITGB3
4 digestive/alimentary MP:0005381 9.8 ALB B2M IL6 ITGB3 TFRC TNF
5 immune system MP:0005387 9.61 B2M CD163 CRP HLA-DRB5 IL6 ITGB3
6 liver/biliary system MP:0005370 9.1 ALB B2M IL6 ITGB3 TFRC TNF

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 3
2 Antibodies Phase 3
3 Vaccines Phase 3,Phase 2,Phase 1
4 Immunoglobulins Phase 3
5
Racepinephrine Approved Phase 2,Phase 1 329-65-7 838
6
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
7
Ribavirin Approved Phase 2 36791-04-5 37542
8 Immunologic Factors Phase 2,Phase 1
9 Epinephryl borate Phase 2,Phase 1
10 Antiviral Agents Phase 2
11 Antimetabolites Phase 2
12 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

41
Kidney, Testes, T Cells, Lung, Liver, Heart, Bone

Publications for Hemorrhagic Fever with Renal Syndrome

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 418)
# Title Authors Year
1
Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report. ( 29508304 )
2018
2
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome. ( 29450213 )
2018
3
Impact of meteorological factors on hemorrhagic fever with renal syndrome in 19 cities in China, 2005-2014. ( 29913587 )
2018
4
Meteorological factors and risk of hemorrhagic fever with renal syndrome in Guangzhou, southern China, 2006-2015. ( 29949572 )
2018
5
Delayed Interferon Type 1-Induced Antiviral State Is a Potential Factor for Hemorrhagic Fever With Renal Syndrome Severity. ( 29281106 )
2018
6
Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29335595 )
2018
7
Absence of a Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Yeoncheon Compared to Nationwide Korea. ( 29968979 )
2018
8
Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome. ( 29373686 )
2018
9
Author Correction: Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29651028 )
2018
10
Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report. ( 29587642 )
2018
11
Landscape and rodent community composition are associated with risk of hemorrhagic fever with renal syndrome in two cities in China, 2006-2013. ( 29329512 )
2018
12
Study on expression of plasma sCD138 in patients with hemorrhagic fever with renal syndrome. ( 29490629 )
2018
13
A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome. ( 29563720 )
2018
14
High Serum Procalcitonin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome Caused by Hantaan Virus. ( 29868489 )
2018
15
Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. ( 29791494 )
2018
16
Involvement of CD8<sup>+</sup> T cells in the development of renal hemorrhage in a mouse model of hemorrhagic fever with renal syndrome. ( 29488118 )
2018
17
Relationship between circulating vascular endothelial growth factor and its soluble receptor in patients with hemorrhagic fever with renal syndrome. ( 29765019 )
2018
18
Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study. ( 29020303 )
2018
19
Expression of CD206 and CD163 on intermediate CD14++CD16+ monocytes are increased in hemorrhagic fever with renal syndrome and are correlated with disease severity. ( 29857122 )
2018
20
Platelet Distribution Width at First Day of Hospital Admission in Patients with Hemorrhagic Fever with Renal Syndrome Caused by Hantaan Virus May Predict Disease Severity and Critical Patients' Survival. ( 30018676 )
2018
21
Spatiotemporal analysis and forecasting model of hemorrhagic fever with renal syndrome in mainland China. ( 30078384 )
2018
22
Two cases of imported hemorrhagic fever with renal syndrome and systematic review of literature. ( 30114480 )
2018
23
Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001-2016. ( 30133872 )
2018
24
Environmental Determinants of Hemorrhagic Fever with Renal Syndrome in High-Risk Counties in China: A Time Series Analysis (2002-2012). ( 30226151 )
2018
25
There is Still Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Gyeonggi Province. ( 30270589 )
2018
26
Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells. ( 30283445 )
2018
27
Spatial heterogeneity of hemorrhagic fever with renal syndrome is driven by environmental factors and rodent community composition. ( 30356291 )
2018
28
A new Seasonal Difference Space-Time Autoregressive Integrated Moving Average (SD-STARIMA) model and spatiotemporal trend prediction analysis for Hemorrhagic Fever with Renal Syndrome (HFRS). ( 30475830 )
2018
29
Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study. ( 29184158 )
2017
30
Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome. ( 28804005 )
2017
31
Analysis of hemorrhagic fever with renal syndrome and its pathogenic gene sequence based on geographic information system. ( 28685549 )
2017
32
Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome. ( 28237172 )
2017
33
Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K<sup>b</sup>Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome. ( 29312318 )
2017
34
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. ( 28572804 )
2017
35
Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS. ( 28411480 )
2017
36
Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ( 28190175 )
2017
37
Anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome. ( 28141833 )
2017
38
Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women. ( 28504470 )
2017
39
The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. ( 28592316 )
2017
40
Prevalence of hemorrhagic fever with renal syndrome in Yiyuan County, China, 2005-2014. ( 26852019 )
2016
41
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. ( 27943332 )
2016
42
Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. ( 27842513 )
2016
43
Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. ( 27786303 )
2016
44
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China. ( 27706256 )
2016
45
Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). ( 27801870 )
2016
46
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 26870699 )
2016
47
Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. ( 26962084 )
2016
48
The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. ( 27824286 )
2016
49
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome. ( 28096800 )
2016
50
Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing. ( 27221218 )
2016

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for Hemorrhagic Fever with Renal Syndrome

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 B2M CRP CXCL8 HLA-B HLA-DRB1 HLA-DRB5
2
Show member pathways
13.14 B2M CXCL8 HLA-B HLA-DRB1 HLA-DRB5 IL6
3
Show member pathways
12.89 B2M CXCL8 HLA-B IL6 ITGB3 TNF
4
Show member pathways
12.88 HLA-B IL6 ITGB3 TNF VTN
5
Show member pathways
12.65 B2M CXCL8 HLA-B HLA-DRB1 HLA-DRB5 IL6
6
Show member pathways
12.62 CXCL8 HLA-B HLA-DRB1 HLA-DRB5 IL6 TNF
7
Show member pathways
12.49 HLA-DRB1 HLA-DRB5 IL6 TNF
8
Show member pathways
12.42 B2M HLA-B HLA-DRB1 HLA-DRB5
9 12.28 HLA-B HLA-DRB1 HLA-DRB5 IL6 TNF
10
Show member pathways
12.23 ALB CRP IL6 TNF
11
Show member pathways
12.16 CXCL8 HLA-B IL6 TNF
12 12.09 HLA-DRB1 HLA-DRB5 IL6 TNF
13 12 HLA-B HLA-DRB1 HLA-DRB5
14 11.94 B2M HLA-B HLA-DRB1 HLA-DRB5 IL6 TNF
15 11.91 CXCL8 IL6 TNF
16 11.9 HLA-B HLA-DRB1 HLA-DRB5 ITGB3 TFRC
17 11.89 CXCL8 IL6 TNF
18 11.86 CD163 IL6 ITGB3 TNF
19 11.84 CXCL8 IL6 VTN
20 11.8 CXCL8 IL6 TNF
21 11.78 CXCL8 IL6 TNF
22 11.67 CXCL8 IL6 TNF
23 11.66 CD163 IL6 TNF
24 11.61 CXCL8 HLA-DRB1 HLA-DRB5 IL6 TNF
25 11.58 CXCL8 IL6 TNF
26
Show member pathways
11.57 CXCL8 IL6 TNF
27 11.56 CD163 IL6 ITGB3 TNF
28 11.49 CXCL8 IL6 TNF
29 11.43 CXCL8 IL6 TNF
30 11.42 CXCL8 IL6 TNF
31 11.4 IL6 TNF VTN
32 11.15 HLA-DRB1 IL6 TNF
33 11.09 HLA-DRB1 HLA-DRB5 IL6 ITGB3 TFRC TNF
34 10.54 CRP CXCL8 IL6 TNF

GO Terms for Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 ALB B2M CD163 CRP CXCL8 IL6
2 external side of plasma membrane GO:0009897 9.77 B2M CD163 HLA-DRB1 TFRC TNF
3 endocytic vesicle membrane GO:0030666 9.63 CD163 HLA-DRB1 HLA-DRB5
4 cell surface GO:0009986 9.63 B2M HLA-B HLA-DRB1 ITGB3 TFRC TNF
5 extracellular space GO:0005615 9.61 ALB B2M CRP CXCL8 IL6 SEMA4D
6 MHC class II protein complex GO:0042613 9.51 HLA-DRB1 HLA-DRB5
7 MHC class I protein complex GO:0042612 9.49 B2M HLA-B
8 HFE-transferrin receptor complex GO:1990712 9.48 B2M TFRC
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.43 HLA-B HLA-DRB1 HLA-DRB5
10 alphav-beta3 integrin-vitronectin complex GO:0071062 9.4 ITGB3 VTN
11 ER to Golgi transport vesicle membrane GO:0012507 8.92 B2M HLA-B HLA-DRB1 HLA-DRB5
12 extracellular exosome GO:0070062 10.03 ALB B2M HLA-B HLA-DRB1 HLA-DRB5 ITGB3
13 integral component of plasma membrane GO:0005887 10 CD163 HLA-B ITGB3 SEMA4D TFRC TNF

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CD163 CRP CXCL8 IL6 TNF
2 receptor-mediated endocytosis GO:0006898 9.76 ALB CD163 TFRC VTN
3 defense response to Gram-positive bacterium GO:0050830 9.7 CRP IL6 TNF
4 viral entry into host cell GO:0046718 9.69 HLA-DRB1 ITGB3 TFRC
5 antigen processing and presentation GO:0019882 9.61 HLA-B HLA-DRB1 HLA-DRB5
6 positive regulation of chemokine production GO:0032722 9.59 IL6 TNF
7 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 ITGB3 VTN
8 embryonic digestive tract development GO:0048566 9.58 CXCL8 TNF
9 positive regulation of glial cell proliferation GO:0060252 9.57 IL6 TNF
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.56 HLA-DRB1 HLA-DRB5
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 IL6 ITGB3 SEMA4D VTN
12 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.55 CRP ITGB3
13 response to molecule of bacterial origin GO:0002237 9.54 B2M CXCL8
14 acute-phase response GO:0006953 9.5 CD163 CRP IL6
15 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.49 B2M HLA-B
16 positive regulation of neuroinflammatory response GO:0150078 9.48 IL6 TNF
17 interferon-gamma-mediated signaling pathway GO:0060333 9.46 B2M HLA-B HLA-DRB1 HLA-DRB5
18 negative regulation of alkaline phosphatase activity GO:0010693 9.37 SEMA4D TNF
19 immune response GO:0006955 9.28 B2M CXCL8 HLA-B HLA-DRB1 HLA-DRB5 IL6
20 negative regulation of lipid storage GO:0010888 9.26 CRP IL6 ITGB3 TNF

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.33 HLA-DRB1 ITGB3 TFRC
2 identical protein binding GO:0042802 9.17 ALB B2M CRP ITGB3 TFRC TNF
3 peptide antigen binding GO:0042605 9.13 HLA-B HLA-DRB1 HLA-DRB5

Sources for Hemorrhagic Fever with Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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