MCID: HMR004
MIFTS: 61

Hemorrhagic Fever with Renal Syndrome

Categories: Infectious diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

MalaCards integrated aliases for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 12 76 44 15 73
Hantavirosis 59 73
Hemorrhagic Fever-Renal Syndrome 59
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hantavirus Fever 59
Hfrs 12

Characteristics:

Orphanet epidemiological data:

59
hemorrhagic fever-renal syndrome
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to acalculous cholecystitis and acute pancreatitis. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Antibodies and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and testes, and related phenotypes are renal insufficiency and proteinuria

Wikipedia : 76 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 acalculous cholecystitis 31.1 CD40LG CRP
2 acute pancreatitis 30.4 CRP IL10 IL6
3 guillain-barre syndrome 30.1 ALB CD40LG TNF
4 hemophagocytic lymphohistiocytosis 30.0 B2M IL10 TNF
5 scrub typhus 29.5 CD40LG CRP IL10 TNF
6 hemorrhagic fever 29.3 ALB CD40LG HLA-DRB1 IL10 IL6 ITGB3
7 leptospirosis 29.3 CD40LG CRP IL10 IL6 TNF
8 chlamydia 29.0 CD40LG CRP IL10 IL6 TNF
9 peritonitis 28.3 ALB B2M CRP IL10 IL6 TNF
10 myocardial infarction 27.7 ALB CD40LG CRP IL10 IL6 ITGB3
11 korean hemorrhagic fever 11.9
12 danubian endemic familial nephropathy 11.4
13 hantavirus pulmonary syndrome 11.4
14 pancreatitis, hereditary 11.0
15 balkan hemorrhagic fever 11.0
16 scorpion envenomation 10.9 IL6 TNF
17 leukomalacia 10.9 IL6 TNF
18 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL6 TNF
19 critical limb ischemia 10.9 IL6 TNF
20 extramedullary plasmacytoma 10.8 B2M IL6
21 streptococcal toxic-shock syndrome 10.8 IL6 TNF
22 sudden sensorineural hearing loss 10.8 IL6 ITGB3
23 null-cell leukemia 10.8 IL6 TNF
24 trench fever 10.8 CD40LG TNF
25 cold agglutinin disease 10.8 CRP IL6
26 encephalitozoonosis 10.8 CD40LG TNF
27 rheumatoid lung disease 10.8 CD40LG TNF
28 miller fisher syndrome 10.8 CD40LG TNF
29 retinitis pigmentosa 55 10.8 IL6 TNF
30 cryopyrin-associated periodic syndrome 10.7 CRP IL6
31 cardiogenic shock 10.7 CRP IL6
32 aids dementia complex 10.7 B2M TNF
33 acute cholangitis 10.7 CRP IL6
34 mononeuritis multiplex 10.7 CD40LG CRP
35 polyclonal hypergammaglobulinemia 10.7 CD40LG IL6
36 laryngitis 10.7 IL6 TNF
37 immunodeficiency 43 10.7 ALB B2M
38 neutrophilia, hereditary 10.7 CRP IL6
39 uremic pruritus 10.7 CRP IL6
40 colorado tick fever 10.7 ALB CD40LG
41 punctate inner choroidopathy 10.6 IL10 TNF
42 cork-handlers' disease 10.6 ALB CD40LG
43 melancholia 10.6 CRP TNF
44 spinal disease 10.6 CRP IL6
45 castleman disease 10.6 CRP IL6
46 tropical endomyocardial fibrosis 10.6 IL10 TNF
47 acute maxillary sinusitis 10.6 CD40LG CRP
48 plasmodium malariae malaria 10.6 ALB CD40LG
49 myelitis 10.6 IL6 ITGB3 TNF
50 japanese spotted fever 10.6 CD40LG CRP

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hemorrhagic Fever with Renal Syndrome

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

59 32 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0000083
2 proteinuria 59 32 frequent (33%) Frequent (79-30%) HP:0000093
3 conjunctivitis 59 32 frequent (33%) Frequent (79-30%) HP:0000509
4 myopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000545
5 photophobia 59 32 frequent (33%) Frequent (79-30%) HP:0000613
6 hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0000822
7 abnormal myocardium morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0001637
8 abnormal pericardium morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0001697
9 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
10 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
11 tubulointerstitial abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0001969
12 leukocytosis 59 32 frequent (33%) Frequent (79-30%) HP:0001974
13 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
14 migraine 59 32 frequent (33%) Frequent (79-30%) HP:0002076
15 respiratory insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0002093
16 hemoptysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002105
17 pulmonary infiltrates 59 32 frequent (33%) Frequent (79-30%) HP:0002113
18 intracranial hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002170
19 pleural effusion 59 32 frequent (33%) Frequent (79-30%) HP:0002202
20 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
21 hypotension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002615
22 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
23 elevated hepatic transaminases 59 32 frequent (33%) Frequent (79-30%) HP:0002910
24 hypoproteinemia 59 32 frequent (33%) Frequent (79-30%) HP:0003075
25 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
26 arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0011675
27 subconjunctival hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0011896
28 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
29 oliguria 59 32 frequent (33%) Frequent (79-30%) HP:0100520
30 amaurosis fugax 59 32 occasional (7.5%) Occasional (29-5%) HP:0100576
31 atelectasis 59 32 frequent (33%) Frequent (79-30%) HP:0100750
32 abnormality of the renal tubule 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 IL10 B2M IL6 CD163 CD40LG ITGB3
2 homeostasis/metabolism MP:0005376 10.11 ALB IL10 B2M IL6 CD163 CD40LG
3 hematopoietic system MP:0005397 10.1 IL10 B2M IL6 CD163 CD40LG ITGB3
4 immune system MP:0005387 10.02 IL10 B2M IL6 CD163 CD40LG ITGB3
5 digestive/alimentary MP:0005381 9.91 ALB IL10 B2M IL6 ITGB3 TNF
6 liver/biliary system MP:0005370 9.73 ALB IL10 B2M IL6 ITGB3 TNF
7 muscle MP:0005369 9.63 ALB IL10 CD163 IL6 ITGB3 TNF
8 neoplasm MP:0002006 9.43 ALB IL10 B2M IL6 ITGB3 TNF
9 skeleton MP:0005390 9.17 IL10 IL6 CD40LG ITGB3 HLA-DRB5 SEMA4D

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 3
2 Antibodies, Blocking Phase 3
3 Immunoglobulins Phase 3
4 Vaccines Phase 3,Phase 2,Phase 1
5
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
6
Racepinephrine Approved Phase 2,Phase 1 329-65-7 838
7
Ribavirin Approved Phase 2 36791-04-5 37542
8 Epinephryl borate Phase 2,Phase 1
9 Anti-Infective Agents Phase 2
10 Antimetabolites Phase 2
11 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

41
Kidney, T Cells, Testes, Endothelial, B Cells, Neutrophil, Liver

Publications for Hemorrhagic Fever with Renal Syndrome

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 402)
# Title Authors Year
1
Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report. ( 29508304 )
2018
2
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome. ( 29450213 )
2018
3
Impact of meteorological factors on hemorrhagic fever with renal syndrome in 19 cities in China, 2005-2014. ( 29913587 )
2018
4
Meteorological factors and risk of hemorrhagic fever with renal syndrome in Guangzhou, southern China, 2006-2015. ( 29949572 )
2018
5
Delayed Interferon Type 1-Induced Antiviral State Is a Potential Factor for Hemorrhagic Fever With Renal Syndrome Severity. ( 29281106 )
2018
6
Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29335595 )
2018
7
Absence of a Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Yeoncheon Compared to Nationwide Korea. ( 29968979 )
2018
8
Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome. ( 29373686 )
2018
9
Author Correction: Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29651028 )
2018
10
Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report. ( 29587642 )
2018
11
Landscape and rodent community composition are associated with risk of hemorrhagic fever with renal syndrome in two cities in China, 2006-2013. ( 29329512 )
2018
12
Study on expression of plasma sCD138 in patients with hemorrhagic fever with renal syndrome. ( 29490629 )
2018
13
A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome. ( 29563720 )
2018
14
High Serum Procalcitonin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome Caused by Hantaan Virus. ( 29868489 )
2018
15
Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. ( 29791494 )
2018
16
Involvement of CD8<sup>+</sup> T cells in the development of renal hemorrhage in a mouse model of hemorrhagic fever with renal syndrome. ( 29488118 )
2018
17
Relationship between circulating vascular endothelial growth factor and its soluble receptor in patients with hemorrhagic fever with renal syndrome. ( 29765019 )
2018
18
Expression of CD206 and CD163 on intermediate CD14<sup>++</sup>CD16<sup>+</sup> monocytes are increased in hemorrhagic fever with renal syndrome and are correlated with disease severity. ( 29857122 )
2018
19
Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study. ( 29020303 )
2018
20
Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study. ( 29184158 )
2017
21
Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome. ( 28804005 )
2017
22
Analysis of hemorrhagic fever with renal syndrome and its pathogenic gene sequence based on geographic information system. ( 28685549 )
2017
23
Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome. ( 28237172 )
2017
24
Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K<sup>b</sup>Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome. ( 29312318 )
2017
25
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. ( 28572804 )
2017
26
Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS. ( 28411480 )
2017
27
Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ( 28190175 )
2017
28
Anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome. ( 28141833 )
2017
29
Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women. ( 28504470 )
2017
30
The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. ( 28592316 )
2017
31
Prevalence of hemorrhagic fever with renal syndrome in Yiyuan County, China, 2005-2014. ( 26852019 )
2016
32
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. ( 27943332 )
2016
33
Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. ( 27842513 )
2016
34
Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. ( 27786303 )
2016
35
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China. ( 27706256 )
2016
36
Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). ( 27801870 )
2016
37
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 26870699 )
2016
38
Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. ( 26962084 )
2016
39
The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. ( 27824286 )
2016
40
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome. ( 28096800 )
2016
41
Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing. ( 27221218 )
2016
42
Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006-2014. ( 26812444 )
2016
43
History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. ( 26636561 )
2016
44
Corrigendum: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 27981038 )
2016
45
Epidemiological analysis of hemorrhagic fever with renal syndrome in China with the seasonal-trend decomposition method and the exponential smoothing model. ( 27976704 )
2016
46
Spatio-Temporal Pattern and Influencing Factors of Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China) between 2005 and 2014. ( 28030550 )
2016
47
Effects of Humidity Variation on the Hantavirus Infection and Hemorrhagic Fever with Renal Syndrome Occurrence in Subtropical China. ( 26711521 )
2016
48
Genovariation Study of Hantavirus in Main Endemic Areas of Hemorrhagic Fever with Renal Syndrome in Hebei Province, China. ( 27442527 )
2016
49
Changes in Plasma Adiponectin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome: An Observational Prospective Study. ( 26871804 )
2016
50
Modeling and predicting hemorrhagic Fever with renal syndrome trends based on meteorological factors in hu county, china. ( 25875211 )
2015

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for Hemorrhagic Fever with Renal Syndrome

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 B2M CD40LG CRP HLA-DRB1 HLA-DRB5 IL10
2
Show member pathways
13.14 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
3
Show member pathways
12.61 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
4 12.44 B2M CD40LG IL10 TNF
5
Show member pathways
12.33 HLA-DRB1 HLA-DRB5 IL10 IL6 TNF
6
Show member pathways
12.32 CD40LG IL10 IL6 TNF
7 12.31 HLA-DRB1 HLA-DRB5 IL6 TNF
8
Show member pathways
12.22 ALB CRP IL6 TNF
9
Show member pathways
12.07 CD40LG HLA-DRB1 HLA-DRB5 IL10 TNF
10 12.02 HLA-DRB1 HLA-DRB5 IL10 IL6 TNF
11 12 HLA-DRB1 HLA-DRB5 ITGB3
12 11.97 CD40LG HLA-DRB1 HLA-DRB5
13 11.87 IL10 IL6 TNF
14 11.78 IL10 IL6 TNF
15 11.73 HLA-DRB1 HLA-DRB5 IL6 TNF
16 11.67 IL10 IL6 TNF
17 11.63 CD163 IL10 IL6 TNF
18 11.62 CD163 IL10 IL6 ITGB3 TNF
19 11.57 CD40LG IL10 ITGB3
20
Show member pathways
11.57 CD40LG IL6 TNF
21 11.5 HLA-DRB1 HLA-DRB5 IL10
22 11.43 IL10 IL6 TNF
23 11.42 IL6 TNF VTN
24 11.26 IL10 IL6 TNF
25 11.25 CD40LG IL10 IL6 TNF
26 11.24 IL10 IL6 TNF
27 11.01 HLA-DRB1 HLA-DRB5 IL6 ITGB3 TNF
28 10.98 IL6 TNF
29 10.95 CRP IL6 TNF
30 10.73 HLA-DRB1 IL10 IL6 TNF

GO Terms for Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 ALB B2M CD163 CD40LG CRP IL10
2 cell surface GO:0009986 9.8 B2M CD40LG HLA-DRB1 ITGB3 TNF
3 endocytic vesicle membrane GO:0030666 9.54 CD163 HLA-DRB1 HLA-DRB5
4 ER to Golgi transport vesicle membrane GO:0012507 9.5 B2M HLA-DRB1 HLA-DRB5
5 MHC class II protein complex GO:0042613 9.43 HLA-DRB1 HLA-DRB5
6 external side of plasma membrane GO:0009897 9.35 B2M CD163 CD40LG HLA-DRB1 TNF
7 extracellular space GO:0005615 9.28 ALB B2M CD40LG CRP IL10 IL6
8 alphav-beta3 integrin-vitronectin complex GO:0071062 9.26 ITGB3 VTN

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 ALB CD40LG IL10 IL6 SEMA4D
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 CD40LG IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.8 IL10 IL6 TNF
4 platelet activation GO:0030168 9.78 CD40LG IL6 ITGB3
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.77 IL10 IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.73 CRP IL6 TNF
7 T cell costimulation GO:0031295 9.7 CD40LG HLA-DRB1 HLA-DRB5
8 interferon-gamma-mediated signaling pathway GO:0060333 9.67 B2M HLA-DRB1 HLA-DRB5
9 response to glucocorticoid GO:0051384 9.65 IL10 IL6 TNF
10 positive regulation of receptor-mediated endocytosis GO:0048260 9.64 B2M VTN
11 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
12 inflammatory response GO:0006954 9.63 CD163 CD40LG CRP IL10 IL6 TNF
13 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.62 ITGB3 VTN
14 cell adhesion mediated by integrin GO:0033627 9.61 ITGB3 VTN
15 negative regulation of growth of symbiont in host GO:0044130 9.6 IL10 TNF
16 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.58 HLA-DRB1 HLA-DRB5
17 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.58 CRP ITGB3
18 response to molecule of bacterial origin GO:0002237 9.57 B2M IL10
19 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 IL6 ITGB3 SEMA4D VTN
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.55 IL10 TNF
21 endothelial cell apoptotic process GO:0072577 9.54 IL10 TNF
22 acute-phase response GO:0006953 9.5 CD163 CRP IL6
23 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 IL10 TNF
24 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
25 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
26 negative regulation of alkaline phosphatase activity GO:0010693 9.37 SEMA4D TNF
27 immune response GO:0006955 9.28 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
28 negative regulation of lipid storage GO:0010888 9.26 CRP IL6 ITGB3 TNF

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 ALB B2M CRP ITGB3 TNF VTN
2 cytokine activity GO:0005125 8.92 CD40LG IL10 IL6 TNF

Sources for Hemorrhagic Fever with Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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