HSES
MCID: HMR014
MIFTS: 19

Hemorrhagic Shock and Encephalopathy Syndrome (HSES)

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hemorrhagic Shock and Encephalopathy Syndrome

MalaCards integrated aliases for Hemorrhagic Shock and Encephalopathy Syndrome:

Name: Hemorrhagic Shock and Encephalopathy Syndrome 20
Hses 20

Classifications:



Summaries for Hemorrhagic Shock and Encephalopathy Syndrome

GARD : 20 Hemorrhagic shock and encephalopathy syndrome (HSES) is a rare disease that occurs suddenly in previously healthy children. This condition is characterized by severe shock, impairment of the blood's ability to clot (coagulopathy), abnormal brain function or structure (encephalopathy), and liver and kidney dysfunction. Most cases of HSES occur in infants from age 3 to 8 months of age, although it can also occur in older children. Individuals with HSES have extremely high body temperatures and multiple organ failures. This condition often causes long term neurological problems or death. The cause of the HSES is unknown. There is no cure for HSES; however, different methods can be used to try to manage associated symptoms.

MalaCards based summary : Hemorrhagic Shock and Encephalopathy Syndrome, also known as hses, is related to encephalopathy and metabolic acidosis. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and colon.

Related Diseases for Hemorrhagic Shock and Encephalopathy Syndrome

Diseases related to Hemorrhagic Shock and Encephalopathy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 encephalopathy 10.9
2 metabolic acidosis 10.5
3 ocular motor apraxia 10.4
4 disseminated intravascular coagulation 10.4
5 brain edema 10.3
6 influenza 10.3
7 diarrhea 10.2
8 acute diarrhea 10.1
9 respiratory failure 10.1
10 pancytopenia 10.1
11 quadriplegia 10.1
12 thrombocytopenia 10.1
13 encephalomalacia 10.1
14 hypoglycemia 10.1
15 cytokine deficiency 10.1

Graphical network of the top 20 diseases related to Hemorrhagic Shock and Encephalopathy Syndrome:



Diseases related to Hemorrhagic Shock and Encephalopathy Syndrome

Symptoms & Phenotypes for Hemorrhagic Shock and Encephalopathy Syndrome

Drugs & Therapeutics for Hemorrhagic Shock and Encephalopathy Syndrome

Drugs for Hemorrhagic Shock and Encephalopathy Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 3 59277-89-3 2022
2 Anti-Infective Agents Phase 3
3 valacyclovir Phase 3
4 Antiviral Agents Phase 3
5
Nicotine Approved 54-11-5 942 89594
6
Metronidazole Approved 443-48-1 4173

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Double-Blind, Placebo-Controlled Trial of Long Term Therapy of Herpes Simplex Encephalitis (HSE): An Evaluation of Valacyclovir (CASG-204) Completed NCT00031486 Phase 3 Valacyclovir;Placebo
2 Behavioral Activation for Smoking Cessation in Veterans With PTSD Completed NCT01995123
3 The Effect of an E-learning Proficiency Based Progression Training Programme for Clinical Communication on ISBAR Performance Completed NCT02937597
4 Effects of an Evidence Service on Health System Policymakers' Use of Research Evidence Withdrawn NCT01307228

Search NIH Clinical Center for Hemorrhagic Shock and Encephalopathy Syndrome

Genetic Tests for Hemorrhagic Shock and Encephalopathy Syndrome

Anatomical Context for Hemorrhagic Shock and Encephalopathy Syndrome

MalaCards organs/tissues related to Hemorrhagic Shock and Encephalopathy Syndrome:

40
Skin, Bone, Colon, Breast, Eye, Kidney, Ovary

Publications for Hemorrhagic Shock and Encephalopathy Syndrome

Articles related to Hemorrhagic Shock and Encephalopathy Syndrome:

(show top 50) (show all 381)
# Title Authors PMID Year
1
Immortalized keratinocytes cells generates an effective model of Epidermal Human Equivalent for irritation and corrosion tests. 61
33309870 2021
2
Molecular characterization of Hsf1 as a master regulator of heat shock response in the thermotolerant methylotrophic yeast Ogataea parapolymorpha. 61
33527316 2021
3
A comparison of the in vitro permeation of 3-O-ethyl-l-ascorbic acid in human skin and in a living skin equivalent (LabSkin™). 61
33238056 2021
4
Elevated cytokine, chemokine, and growth and differentiation factor-15 levels in hemorrhagic shock and encephalopathy syndrome: A retrospective observational study. 61
33032108 2021
5
Dysfunctional family functioning in high socioeconomic status families as a risk factor for the development of psychiatric disorders in adoptees: the Finnish Adoptive Family Study of Schizophrenia. 61
33398497 2021
6
A Novel Three-Dimensional Skin Disease Model to Assess Macrophage Function in Diabetes. 61
33280487 2021
7
Evolution of chaperome gene expression and regulatory elements in the antarctic notothenioid fishes. 61
33149264 2020
8
The soybean gene GmHsp22.4 is involved in the resistance response to Meloidogyne javanica in Arabidopsis thaliana. 61
33234121 2020
9
Synthesis of Steryl Hydroxycinnamates to Enhance Antioxidant Activity of Rapeseed Oil and Emulsions. 61
33066089 2020
10
Successful Outcome in an Adult Patient with Influenza-associated Hemorrhagic Shock and Encephalopathy Syndrome. 61
32522919 2020
11
A solid doxycycline HP-β-CD formulation for reconstitution (i.v. bolus) prepared by scaled-up electrospinning. 61
32534161 2020
12
A human skin equivalent burn model to study the effect of a nanocrystalline silver dressing on wound healing. 61
32830005 2020
13
The multimorbidity profile of South African women newly diagnosed with breast cancer. 61
31600408 2020
14
A Comparative Study of Engineered Dermal Templates for Skin Wound Repair in a Mouse Model. 61
32630398 2020
15
A Simple Method for the Production of Human Skin Equivalent in 3D, Multi-Cell Culture. 61
32629914 2020
16
Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues. 61
31705627 2020
17
A Flexible Ceramic/Polymer Hybrid Solid Electrolyte for Solid-State Lithium Metal Batteries. 61
32173931 2020
18
Access and Outcomes Among Hypertrophic Cardiomyopathy Patients in a Large Integrated Health System. 61
31973610 2020
19
Basal hsp70 expression levels do not explain adaptive variation of the warm- and cold-climate O3 + 4 + 7 and OST gene arrangements of Drosophila subobscura. 61
32005133 2020
20
Optical investigation of three-dimensional human skin equivalents: A pilot study. 61
31593618 2020
21
Physiological Functions of Heat Shock Proteins. 61
31713482 2020
22
Varying Architecture of Heat Shock Elements Contributes to Distinct Magnitudes of Target Gene Expression and Diverged Biological Pathways in Heat Stress Response of Bread Wheat. 61
32117446 2020
23
Diversification of the Caenorhabditis heat shock response by Helitron transposable elements. 61
31825311 2019
24
Contribution of Palmitic Acid to Epidermal Morphogenesis and Lipid Barrier Formation in Human Skin Equivalents. 61
31810180 2019
25
CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells. 61
31818947 2019
26
Cloning and Expression Analysis of the BocMBF1c Gene Involved in Heat Tolerance in Chinese Kale. 61
31718028 2019
27
Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents. 61
31321505 2019
28
Remodeling of the Caenorhabditis elegans non-coding RNA transcriptome by heat shock. 61
31396626 2019
29
Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study. 61
31533688 2019
30
Reconstructing the late-accretion history of the Moon. 61
31292556 2019
31
Characterization of human skin equivalents developed at body's core and surface temperatures. 61
30945465 2019
32
Human skin equivalents cultured under hypoxia display enhanced epidermal morphogenesis and lipid barrier formation. 61
31127151 2019
33
Shedding light on the effects of 1,25-dihydroxyvitamin D3 on epidermal lipid barrier formation in three-dimensional human skin equivalents. 61
30711472 2019
34
Influenza A with hemorrhagic shock and encephalopathy syndrome in an adult: A case report. 61
30946330 2019
35
Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues. 61
30568176 2019
36
3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components. 61
29709325 2019
37
A nationwide survey of norovirus-associated encephalitis/encephalopathy in Japan. 61
30798941 2019
38
Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup. 61
29412486 2019
39
Prevention of Surgical Infections: Building or Renovating a New Intensive Care Unit. 61
30489217 2019
40
Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility. 61
31148082 2019
41
Human Skin Equivalents Demonstrate Need for Neuro-Immuno-Cutaneous System. 61
32627348 2019
42
Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome. 61
30332327 2018
43
Regulatory motifs found in the small heat shock protein (sHSP) gene family in tomato. 61
30537925 2018
44
Is it really "all in their heads"? How self-esteem predicts partner responsiveness. 61
29315572 2018
45
Heat shock transcription factor 3 regulates plant immune response through modulation of salicylic acid accumulation and signalling in cassava. 61
29660238 2018
46
Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1). 61
29661622 2018
47
Induction of ubiquitin C (UBC) gene transcription is mediated by HSF1: role of proteotoxic and oxidative stress. 61
30186748 2018
48
Multiple Modes of Adaptation: Regulatory and Structural Evolution in a Small Heat Shock Protein Gene. 61
30020488 2018
49
Homogenization of Amorphous Solid Dispersions Prepared by Electrospinning in Low-Dose Tablet Formulation. 61
30072667 2018
50
Type IV collagen aggregates promote keratinocyte proliferation and formation of epidermal layer in human skin equivalents. 61
28266764 2018

Variations for Hemorrhagic Shock and Encephalopathy Syndrome

Expression for Hemorrhagic Shock and Encephalopathy Syndrome

Search GEO for disease gene expression data for Hemorrhagic Shock and Encephalopathy Syndrome.

Pathways for Hemorrhagic Shock and Encephalopathy Syndrome

GO Terms for Hemorrhagic Shock and Encephalopathy Syndrome

Sources for Hemorrhagic Shock and Encephalopathy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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