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MCID: HMR005
MIFTS: 49

Hemorrhoid

Categories: Cardiovascular diseases, Gastrointestinal diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hemorrhoid

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MalaCards integrated aliases for Hemorrhoid:

Name: Hemorrhoid 12 73 15 17
Hemorrhoids 42 44 15 70
Hemorrhoidal Disease 12
Rectal Diseases 70

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Gastrointestinal diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9746
ICD9CM 34 455
MeSH 44 D006484
NCIt 50 C26792
SNOMED-CT 67 70153002
UMLS 70 C0019112 C0034882
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Summaries for Hemorrhoid

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MedlinePlus : 42 What are hemorrhoids? Hemorrhoids are swollen, inflamed veins around your anus or the lower part of your rectum. There are two types: External hemorrhoids, which form under the skin around your anus Internal hemorrhoids, which form in the lining of your anus and lower rectum What causes hemorrhoids? Hemorrhoids happen when there is too much pressure on the veins around the anus. This can be caused by Straining during bowel movements Sitting on the toilet for long periods of time Chronic constipation or diarrhea A low-fiber diet Weakening of the supporting tissues in your anus and rectum. This can happen with aging and pregnancy. Frequently lifting heavy objects What are the symptoms of hemorrhoids? The symptoms of hemorrhoids depend on which type you have: With external hemorrhoids, you may have Anal itching One or more hard, tender lumps near your anus Anal pain, especially when sitting Too much straining, rubbing, or cleaning around your anus may make your symptoms worse. For many people, the symptoms of external hemorrhoids go away within a few days. With internal hemorrhoids, you may have Bleeding from your rectum - you would see bright red blood in your stool, on toilet paper, or in the toilet bowl after a bowel movement Prolapse, which is a hemorrhoid that has fallen through your anal opening Internal hemorrhoids are usually not painful unless they are prolapsed. Prolapsed internal hemorrhoids may cause pain and discomfort. How can I treat hemorrhoids at home? You can most often treat your hemorrhoids at home by Eating foods that are high in fiber Taking a stool softener or a fiber supplement Drinking enough fluids every day Not straining during bowel movements Not sitting on the toilet for long periods of time Taking over-the-counter pain relievers Taking warm baths several times a day to help relieve pain. This could be a regular bath or a sitz bath. With a sitz bath, you use a special plastic tub that allows you to sit in a few inches of warm water. Using over-the-counter hemorrhoid creams, ointments, or suppositories to relieve mild pain, swelling, and itching of external hemorrhoids When do I need to see a health care provider for hemorrhoids? You should see your health care provider if you Still have symptoms after 1 week of at-home treatment Have bleeding from your rectum. Hemorrhoids are a common cause of bleeding, but other conditions can also cause bleeding. They include Crohn's disease, ulcerative colitis, colorectal cancer, and anal cancer. So it's important to see your provider to find the cause of the bleeding. How are hemorrhoids diagnosed? To make a diagnosis, your health care provider Will ask about your medical history Will do a physical exam. Often providers can diagnose external hemorrhoids by looking at the area around your anus. Will do a digital rectal exam to check for internal hemorrhoids. For this, the provider will insert a lubricated, gloved finger into the rectum to feel for anything that is abnormal. May do procedures such as an anoscopy to check for internal hemorrhoids What are the treatments for hemorrhoids? If at-home treatments for hemorrhoids don't help you, you may need a medical procedure. There are several different procedures that your provider can do in the office. These procedures use different techniques to cause scar tissue to form in the hemorrhoids. This cuts off the blood supply, which usually shrinks the hemorrhoids. In severe cases, you may need surgery. Can hemorrhoids be prevented? You can help prevent hemorrhoids by Eating foods that are high in fiber Taking a stool softener or a fiber supplement Drinking enough fluids every day Not straining during bowel movements Not sitting on the toilet for long periods of time NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hemorrhoid, also known as hemorrhoids, is related to internal hemorrhoid and anus disease, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Folate Metabolism and Photodynamic therapy-induced NF-kB survival signaling. The drugs Glycerol and Menthol have been mentioned in the context of this disorder. Affiliated tissues include colon, prostate and spinal cord, and related phenotype is digestive/alimentary.

Disease Ontology : 12 A pelvic varices that is characterized by swollen, inflamed veins around the anus or lower rectum.

Wikipedia : 73 Hemorrhoids, also spelled haemorrhoids, are vascular structures in the anal canal. In their normal... more...

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Related Diseases for Hemorrhoid

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Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 594)
# Related Disease Score Top Affiliating Genes
1 internal hemorrhoid 31.4 NOS2 MMP9 F2 CRP ATP4A ATP12A
2 anus disease 31.1 TNF CRP CEACAM5 ALB
3 rectal disease 30.8 TNF KLK3 CRP CEACAM5 ALB
4 functional diarrhea 30.2 ATP4A ATP12A
5 hernia, hiatus 30.1 CRP ATP4A ATP12A
6 giardiasis 30.0 ATP4A ATP12A ALB
7 varicocele 29.9 TNF NOS2 ALB
8 spinal cord injury 29.9 TNF NOS2 MMP9
9 proctitis 29.9 TNF KLK3 CRP
10 anal fistula 29.9 TNF MMP9 MIR6086 MIR1185-1 CRP
11 thrombophlebitis 29.7 F2 CRP ALB
12 lactose intolerance 29.7 CRP ATP4A ATP12A ALB
13 gastroenteritis 29.7 TNF MMP9 CRP ALB
14 acquired immunodeficiency syndrome 29.7 TNF NOS2 CRP ALB
15 dieulafoy lesion 29.7 F2 ATP4A ATP12A
16 constipation 29.6 NOS2 GPT CRP ATP4A ATP12A ALB
17 cholelithiasis 29.6 GPT CRP ALB
18 scarlet fever 29.6 TNF CRP ALB
19 varicose veins 29.6 TNF MMP9 F2
20 chronic venous insufficiency 29.5 MMP9 F2 CRP
21 venous insufficiency 29.5 MMP9 F2 CRP
22 bronchitis 29.5 TNF MMP9 CRP ALB
23 portal hypertension 29.5 TNF GPT F2 ALB
24 meningitis 29.5 TNF MMP9 CRP ALB
25 aortic aneurysm, familial abdominal, 1 29.5 TNF MMP9 CRP ALB
26 pulmonary disease, chronic obstructive 29.4 TNF MMP9 CRP ALB
27 acute kidney failure 29.2 GPT F2 ALB
28 volvulus of midgut 29.2 GPT CRP ATP4A ATP12A ALB
29 infective endocarditis 29.2 TNF F2 CRP
30 disease by infectious agent 29.1 TNF GPT CRP ALB
31 esophageal varix 29.1 GPT F2 ATP4A ATP12A ALB
32 pleural empyema 29.0 GPT F2 CRP ALB
33 liver cirrhosis 29.0 TNF GPT F2 CRP ALB
34 endocarditis 29.0 TNF F2 CRP ALB
35 intestinal obstruction 28.8 TNF GPT CRP CEACAM5 ATP4A ATP12A
36 inflammatory bowel disease 28.7 TNF NOS2 MMP9 F2 CRP ALB
37 vascular disease 28.6 TNF NOS2 MMP9 F2 CRP ALB
38 compartment syndrome 28.6 TNF GPT F2 CRP ALB
39 migraine with or without aura 1 28.5 TNF F2 CRP ATP4A ATP12A ALB
40 respiratory failure 28.5 TNF GPT F2 CRP ALB
41 exanthem 28.2 TNF GPT F2 CRP ATP4A ATP12A
42 malaria 28.2 TNF NOS2 MMP9 GPT F2 CRP
43 deficiency anemia 28.1 TNF GPT F2 CRP ATP4A ATP12A
44 type 2 diabetes mellitus 28.1 TNF NOS2 MMP9 GPT F2 CRP
45 diabetes mellitus 27.9 TNF NOS2 MMP9 KLK3 GPT F2
46 perianal hematoma 10.9
47 vagus nerve disease 10.4 ATP4A ATP12A
48 scalp dermatosis 10.4 ATP4A ATP12A
49 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
50 acquired gastric outlet stenosis 10.4 ATP4A ATP12A

Graphical network of the top 20 diseases related to Hemorrhoid:



Diseases related to Hemorrhoid
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Symptoms & Phenotypes for Hemorrhoid

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UMLS symptoms related to Hemorrhoid:


nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; rectal tenesmus; heartburn; pruritus ani; gastrointestinal gas; rectal pain

MGI Mouse Phenotypes related to Hemorrhoid:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 ALB ATP12A ATP4A F2 KIAA1217 MMP9
Sources

Drugs & Therapeutics for Hemorrhoid

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Drugs for Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4 56-81-5 753
2
Menthol Approved Phase 4 2216-51-5 16666
3
Borage oil Approved, Investigational Phase 4
4
Prilocaine Approved Phase 4 721-50-6 4906
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
7
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
8
Metronidazole Approved Phase 4 443-48-1 4173
9
Morphine Approved, Investigational Phase 4 57-27-2 5288826
10
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
11
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
14
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
15
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
16
tannic acid Approved Phase 4 1401-55-4
17
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
18
Magnesium oxide Approved Phase 4 1309-48-4 14792
19
Magnesium hydroxide Approved, Investigational Phase 4 1309-42-8
20
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
21
Ibuprofen Approved Phase 4 15687-27-1 3672
22
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
23
Ethanol Approved Phase 4 64-17-5 702
24
Estazolam Approved, Illicit Phase 4 29975-16-4 3261
25
Lactulose Approved Phase 4 4618-18-2 11333
26
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
27
Lecithin Experimental Phase 4 8002-43-5
28 Aloe Phase 4
29 Soy Bean Phase 4
30 Devil's Claw Phase 4
31 Borage Phase 4
32 Gotu Kola Phase 4
33 Arnica Phase 4
34 Anti-Arrhythmia Agents Phase 4
35 Sodium Channel Blockers Phase 4
36 Diuretics, Potassium Sparing Phase 4
37 Anti-Bacterial Agents Phase 4
38 Calcium Dobesilate Phase 4
39 Analgesics, Non-Narcotic Phase 4
40 Antirheumatic Agents Phase 4
41 Anti-Inflammatory Agents Phase 4
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4
43 abobotulinumtoxinA Phase 4
44 Cholinergic Agents Phase 4
45 Botulinum Toxins Phase 4
46 Botulinum Toxins, Type A Phase 4
47 Antiparasitic Agents Phase 4
48 Antiprotozoal Agents Phase 4
49 Anti-Infective Agents Phase 4
50 Cyclooxygenase Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 168)
# Name Status NCT ID Phase Drugs
1 Prospective and Randomized Trial Comparing Dopplper-Guided Transanal Hemorrhoid Artery Ligation With Recto-anal Repair (HAL-RAR) Versus Excisional Hemorrhoidectomy for the Treatment of Grade III-IV Hemorrhoids Unknown status NCT02216305 Phase 4
2 Irritation and Anal Bleeding in Patients Affected by Hemorrhoids: Comparative Evaluation of Three Different Treatments. Unknown status NCT03569930 Phase 4 flavonoid-based supplements;Centella Complex
3 Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy: A Randomized Double-blind Controlled Trial Unknown status NCT01099605 Phase 4
4 Effect of Perioperative i.v. Low-dose S(+) Ketamine in Patients Undergoing Hemorrhoidectomy Completed NCT00354029 Phase 4 S (+) Ketamine;Placebo
5 Calcium Dobesilate vs Flavonoids for the Treatment of Early Hemorrhoidal Disease a Randomised Triple Blind Controlled Trial Completed NCT02782455 Phase 4 Flavonoids;CDobi
6 A Comparative Clinical Research on Therapeutic Effect and Safety of Compound Carraghenates Cream Versus Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids Completed NCT01881282 Phase 4 Carraghenates Cream;Mayinglong Musk Hemorrhoid Ointment
7 The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
8 Randomized Clinical Trial of Botulinum Toxin Injection for Pain Relief in Patients With Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
9 Prospective Randomized Trial on Surgical Treatment of Grade 3 Hemorrhoids: Hemorrhoidectomy Versus Doppler-guided Transanal Haemorrhoidal Dearterialisation and Anopexy Completed NCT01263431 Phase 4
10 Symptom Control 1-year After Circular Stapler Anopey or Diathermy Excision for Prolapsed Haemorrhoids: an International Randomsed Trial (the STOPP-trial Completed NCT00841620 Phase 4
11 Assessment of the Analgesic Efficacy of Morphine Chloride in Addition to a Low Dose Solution of Spinal Anaesthetic in Hemorrhoidectomy Compared to a Standard Dose of Spinal Local Anaesthetic. Simple Blind, Randomized, With Blinded Evaluation by Third Parties Clinical Trial. Completed NCT02046772 Phase 4 Bupivacaine low dose;Bupivacaine standard dose;Morphine Chloride
12 A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Versus Oral Metronidazole in Reducing Post-Operative Pain Following Excisional Haemorrhoidectomy Completed NCT03343509 Phase 4 Metronidazole Oral;Metronidazole Ointment;Placebo Oral Tablet;Placebo Ointment
13 Comparing the Effects of Levobupivacaine and Bupivacaine in Anorectal Surgery Under Saddle Spinal Anesthesia Completed NCT04245774 Phase 4 Levobupivacaine (as Levobupivacaine Hydrochloride) 75 Mg/10 mL Solution for Injection Ampoule;Bupivacaine/Dextrose
14 Double-blinded Multicenter Randomized Clinical Trial to Evaluate the Efficacy and Safety of CLIFE1 and CLIFE2 Gels in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
15 Perianal Nerval Block in Proctological Interventions: a Prospective Randomized Double Blinded Study Completed NCT03405922 Phase 4 Placebo 40 mL Saline 0.9%;40 mL Ropivacain 0.5%
16 A Multicenter Prospective Clinical Study of Endoscopic Foam Sclerotherapy for Internal Hemorrhoids Recruiting NCT04398823 Phase 4 Sclerosing foam of Lauromacrogol;Sclersing liqiud of Lauromacrogol
17 Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial. Recruiting NCT04248205 Phase 4 Ketamine
18 Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery Recruiting NCT03738904 Phase 4
19 The First Affiliated Hospital of Guangzhou University of Chinese Medicine Active, not recruiting NCT03997058 Phase 4 Oral estazolam medication
20 An Open, Randomized, Parallel Group, Single Center Study to Investigate the Effect of Lactulose Versus Plantago Ovate on the Quality of Life of Patients With Hard Stools and Hemorrhoids or Anal Fissure Terminated NCT00160290 Phase 4 Lactulose;Plantago ovata
21 Comparison of Rectal Infiltration of Exparel vs. 0.25% Bupivacaine With Epinephrine vs. Placebo for Analgesic Benefit Following Hemorrhoidectomy Terminated NCT02104414 Phase 4 Exparel;Bupivacaine HCl with Epinephrine;Normal Saline
22 Multi-drug Analgesia Versus Standard Solution for Perianal Block - A Prospective Study to Determine the Efficacy, Cost and Narcotic Consumption in the Post-operative Period Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
23 Local vs General Anaesthesia in Stapled Hemorrhoidectomy: A Multicentric Controlled Randomized Trial Withdrawn NCT00512044 Phase 4
24 Phase 3 Clinical Trial - Efficacy and Safety Evaluation of the Drug Imescard Compound Water Smartweed, Adrenalin and Hamamelis Ointment Unknown status NCT00935948 Phase 3 Imescard compound water smartweed ointment;Placebo
25 Prospective Randomized Trial Comparing Transanal Doppler de-Arterialization (THD) Versus Stapler Operation for 3rd Degree Hemorrhoids Unknown status NCT00823784 Phase 3
26 Clinical Efficacy and Safety Evaluation of the Drug Imescard Compound Water Smartweed Pills Unknown status NCT00861562 Phase 3 Imescard water smartweed composed pills;Placebo
27 Double Blinded Randomized Clinical Trial of the Efficacy of Topical 2% Lidocaine for the Treatment of Symptomatic Hemorrhoids Unknown status NCT01961739 Phase 2, Phase 3 2% lidocaine;placebo
28 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
29 Randomized Controlled Trials of Diet and Lifestyle Intervention to Promote Chinese Postpartum Women's Health Unknown status NCT01039051 Phase 2, Phase 3
30 Topical Anesthesia Versus Placebo to Decrease Post Procedure Pain in Rubber Band Ligation for the Treatment of Grade I - III Symptomatic Internal Hemorrhoids. A Single Institution, Double Blinded, Placebo Controlled Trial. Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
31 Safety and Short Term Effectiveness of EEA Stapler vs PPH Stapler in the Treatment of III Degree Haemorrhoids. Prospective Randomized Controlled Trial Completed NCT01413867 Phase 3
32 Phase 3, Multicenter, Randomized, Double-Blind, Parallel-group, Active-control Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy Completed NCT00744848 Phase 3 Bupivacaine HCl;SKY0402
33 Sclerotherapy With Polidocanol Foam Versus Hemorrhoidal Artery Ligation With Recto Anal Repair in the Treatment of Second and Third-grade Hemorrhoidal Disease: a Prospective Study Completed NCT04675177 Phase 2, Phase 3 Polidocanol foam sclerotherapy
34 A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy Completed NCT00890721 Phase 3 SKY0402;Placebo
35 A Prospective, Randomized, Three Arms, Open Label Study Comparing the Safety and Efficacy of Two Formulations of PP110 to the Active Comparator Preparation-H® Cream in the Treatment of Bleeding Hemorrhoids Grades 2-3 Completed NCT02010099 Phase 2, Phase 3 PP110 Gel;PP110 Medicated wipes;Preparation-H Cream
36 Effectiveness of Metronidazole Versus Homologated Placebo in Pain Control Posthemorrhoidectomy Completed NCT02328144 Phase 3 Metronidazole;Placebo
37 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
38 Pudendal Nerve Block in Patient Treated for Hemorrhoidectomy Under Spinal Anaesthesia: Prospective Randomized Double-blind Controlled Trial Completed NCT04251884 Phase 3
39 A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Metronidazole, Diltiazem and Lidocaine on Post-Operative Pain Following Excisional Haemorrhoidectomy Recruiting NCT04276298 Phase 2, Phase 3 Metronidazole cream;Metronidazole and Diltiazem cream;Metronidazole and Lidocaine cream;Metronidazole, Diltiazem and Lidocaine cream
40 A Randomised Controlled Trial Comparing Conventional Open Haemorrhoidectomy and Laser Haemorrhoidoplasty in the Treatment of Symptomatic Haemorrhoids: COHLAH Trial Recruiting NCT04329364 Phase 2, Phase 3
41 Sclerotherapy With Polidocanol Foam In The Management Of First, Second And Third-Grade Hemorrhoidal Disease In Patients With Bleeding Disorders: A Prospective Cohort Study Active, not recruiting NCT04188171 Phase 2, Phase 3
42 Topical Endorectal Vietamin E Ovules for the Treatment of Grade 2 and 3 Hemorrhoids Not yet recruiting NCT04362384 Phase 3 Vitamin E ovules;Prednisolone ointment
43 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of Intra-Anal Application of Iferanserin (10 mg) as a 0.5% Ointment in Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
44 Double Blind Randomized Placebo-control Trial of Allium Ampeloprasum Spp.Iranicum Cream Effect for the Management of Hemorrhoids Symptoms Unknown status NCT02301052 Phase 1, Phase 2 Leek topical cream;placebo topical cream;Anti-hemorrhoid topical cream
45 Is Greater Downstaging and Tumour Regression Observed When Surgery is Delayed to 12 Weeks After Completion of Chemoradiotherapy vs 6 Weeks? Unknown status NCT01037049 Phase 2
46 Sclerotherapy With Polidocanol Foam Versus Rubber Band Ligation in the Treatment of First, Second and Third-Grade Hemorrhoidal Disease: a Randomized, Controlled Trial Completed NCT04091763 Phase 2 Polidocanol Injectable Foam
47 Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease Completed NCT03791775 Phase 2 Polidocanol foam (Atossisclerol® 3%)
48 Double-blind, Randomized, Placebo-controlled, Dose Response Study to Evaluate the Safety and Efficacy of Three Doses of Euphorbia Prostrata Dry Extract Tablets in Patients of Hemorrhoids Completed NCT01041911 Phase 2 Euphorbia tablets;Euphorbia tablets;Euphorbia tablets;Placebo tablets
49 Protocol for the Study of the Effects of S-MPEC (Iferanserin) in Patients With Hemorrhoids Completed NCT01483833 Phase 2 Iferanserin;Placebo
50 A Randomized, Dose-Ranging, Double Blind Study of Lidocaine Hydrochloride and/or Hydrocortisone Acetate (Alone or in Combination) in the 14-Day Twice-Daily Treatment of Grade I or II Hemorrhoids Completed NCT02689856 Phase 2 Hydrocortisone acetate and lidocaine hydrochloride;Placebo control;Hydrocortisone acetate;Lidocaine hydrochloride

Search NIH Clinical Center for Hemorrhoid

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Benzocaine
BENZOCAINE PWDR
Hydrocortisone
hydrocortisone acetate
HYDROCORTISONE ACETATE PWDR
HYDROCORTISONE ACETONIDE
Hydrocortisone butyrate
hydrocortisone cypionate
hydrocortisone probutate
HYDROCORTISONE PWDR
Hydrocortisone sodium phosphate
Hydrocortisone sodium succinate
hydrocortisone valerate
HYDROCORTISONE,NONSTERILE PWDR
Phenylephrine
Phenylephrine bitartrate
Phenylephrine Hydrochloride
Phenylephrine Tannate
pramoxine
Pramoxine hydrochloride
Psyllium
PSYLLIUM HYDROCOLLOID
Witch Hazel

Cochrane evidence based reviews: hemorrhoids

Sources

Genetic Tests for Hemorrhoid

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Anatomical Context for Hemorrhoid

About this section

MalaCards organs/tissues related to Hemorrhoid:

40
Colon, Prostate, Spinal Cord, Liver, Endothelial, Smooth Muscle, Appendix
Sources

Publications for Hemorrhoid

About this section

Articles related to Hemorrhoid:

(show top 50) (show all 3298)
# Title Authors PMID Year
1
Belgian consensus guideline on the management of hemorrhoidal disease. 61 42
33639701 2021
2
Colonoscopy findings in lower gastrointestinal bleeding in Lagos: A comparative study based on age. 61 42
33355817 2020
3
Tissue selecting technique mega-window stapler combined with anal canal epithelial preservation operation for the treatment of severe prolapsed hemorrhoids: A study protocol for a randomized controlled trial. 61 42
33157990 2020
4
Laparoscopic anterior resection for rectal stenosis caused by ALTA injection for internal hemorrhoids: A case report. 61
32789974 2021
5
SICCR web-educational colorectal meeting "Hemorrhoids and fissures": Congress report. 61
33687581 2021
6
A national evaluation of opioid prescribing and persistent use after ambulatory anorectal surgery. 61
33288211 2021
7
Clinical Outcomes and Effectiveness of Laser Treatment for Hemorrhoids: A Systematic Review. 61
33469736 2021
8
Analysis of risk factors for delayed bleeding after semi-closed hemorrhoidectomy. 61
33661360 2021
9
Clinical study of use of large C suture in procedure for prolapse and hemorrhoids for treatment of mixed hemorrhoids. 61
33682485 2021
10
Rubber band ligation of symptomatic hemorrhoids: an old solution to an everyday problem. 61
33751210 2021
11
Anal squamous cell carcinoma incidentally found at hemorrhoidectomy. 61
33004218 2021
12
Phytochemical and biological activities of Pinus halepensis mill., and their ethnomedicinal use. 61
33276057 2021
13
A synchronous fluorescence spectrofluorometric method for the simultaneous determination of policresulen and cinchocaine hydrochloride in ointment and suppositories. 61
33744839 2021
14
Review on pharmacological and phytochemical prospects of traditional medicinal plant: Persicaria hydropiper (Smartweed). 61
33655861 2021
15
Anorectal Melanoma as an Unexpected Diagnosis for a Pigmented Mass Resembling a Thrombosed Hemorrhoid. 61
31786326 2021
16
A comprehensive review on the ethnopharmacology, phytochemistry, ‎pharmacology, and toxicology of the Mandragora genus; from folk ‎medicine to the modern. 61
33535944 2021
17
Pudendal Nerve Block In Hemorrhoid Surgery: A Systematic Review and Meta-analysis. 61
33591044 2021
18
Efficacy and safety of pudendal nerve block for postoperative analgesia of hemorrhoids: a systematic review of 7 randomized controlled trials. 61
33549027 2021
19
Protective role of rutin against combined exposure to lipopolysaccharide and D-galactosamine-induced dysfunctions in liver, kidney, and brain: Hematological, biochemical, and histological evidences. 61
33433008 2021
20
Study of Flebogrif®-A New Tool for Mechanical Sclerotherapy-Effectiveness Assessment Based on Animal Model. 61
33669987 2021
21
Detection of Somatic Mutations with ddPCR from Liquid Biopsy of Colorectal Cancer Patients. 61
33669856 2021
22
MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14. 61
33708859 2021
23
Use of ultrasound for intersphincteric plane anesthesia in hemorrhoids surgeries. 61
33075635 2021
24
Efficacy of modified rubber band ligation in the treatment of grade III internal hemorrhoids. 61
33081476 2021
25
Successful endoscopic management of 3 cases of translocated intrauterine devices: a case report. 61
33615801 2021
26
Venous Lakes of the Lips Successfully Treated With a Sclerosing Agent 1% polidocanol: analysis of 25 report cases. 61
33373920 2021
27
The clinical features of chronic intestinal schistosomiasis-related intestinal lesions. 61
33407185 2021
28
Ethnobotanical characterization of medicinal plants used in Kisantu and Mbanza-Ngungu territories, Kongo-Central Province in DR Congo. 61
33485383 2021
29
Postoperative Complications in Hemorrhoidal Disease and Special Conditions. 61
32250228 2021
30
Evaluation of a Minimally Invasive Bipolar Coagulation System for the Treatment of Grade I and II Internal Hemorrhoids. 61
33496474 2021
31
Management of Hemorrhoidal Disease in Special Conditions: A Word of Caution. 61
32250231 2021
32
Ligasure Hemorrhoidectomy: Updates on Complications After an 18-Year Experience. 61
33023436 2021
33
Opioid Consumption Patterns After Anorectal Operations: Development of an Institutional Prescribing Guideline. 61
33306536 2021
34
Internal hemorrhoid harboring adenocarcinoma: A case report. 61
33510851 2021
35
Estimates of Alpha/Beta (α/β) Ratios for Individual Late Rectal Toxicity Endpoints: An Analysis of the CHHiP Trial. 61
33412260 2021
36
Evaluation of clinical efficacy of suture-fixation mucopexy in the treatment of prolapsed hemorrhoid. 61
33433071 2021
37
Hemorrhoid laser procedure (HeLP) for second- and third-degree hemorrhoids: results from a long-term follow-up analysis. 61
33439376 2021
38
Doppler-guided hemorrhoidal dearterialization with laser (HeLP): indications and clinical outcome in the long-term. Results of a multicenter trial. 61
33415419 2021
39
Outcome of Stapled Hemorrhoidopexy: Experience of 90 Cases. 61
33397868 2021
40
Superior rectal artery embolization for bleeding internal hemorrhoids. 61
32712932 2021
41
Management of intractable pain in patients treated with hemorrhoidectomy for mixed hemorrhoids. 61
33545778 2021
42
Do We Have Another Option to Treat Bleeding Hemorrhoids? The Emborrhoid Technique: Experience in 16 Patients. 61
32167429 2021
43
Modified procedure for prolapse and hemorrhoids: Lower recurrence, higher satisfaction. 61
33511170 2021
44
Embolization of the superior rectal artery: another management option for hemorrhoids. 61
33156412 2021
45
A flexible silicone patch for treatment of hemorrhoids after birth: a pilot study of HEMOCIN® Patch. 61
33392664 2021
46
Sclerotherapy with 3% polidocanol foam for third- and fourth-degree hemorrhoids as "bridge treatment" during the COVID-19 pandemic in Italy. 61
33452908 2021
47
Conservative Treatment of Hemorrhoidal Disease. 61
33087033 2021
48
The Management of Acute Hemorrhoidal Disease. 61
32223737 2021
49
Topical Diltiazem Ointment For Post- Hemorrhoidectomy Pain. 61
33774968 2021
50
Hemorrhoidal Laser Procedure (HeLP) and Hemorrhoidal Laser Procedure + Mucopexy (HeLPexx) and Other Emerging Technologies. 61
32250230 2021
Sources

Variations for Hemorrhoid

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Expression for Hemorrhoid

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Search GEO for disease gene expression data for Hemorrhoid.
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Pathways for Hemorrhoid

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Pathways related to Hemorrhoid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 11.79 TNF F2 CRP ALB
2
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.93 TNF NOS2 MMP9
3
MSP-RON Signaling 63
10.48 TNF NOS2 KLK3
Sources

GO Terms for Hemorrhoid

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Cellular components related to Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF MMP9 KLK3 GPT F2 CRP

Biological processes related to Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion export across plasma membrane GO:0036376 9.32 ATP4A ATP12A
2 cellular potassium ion homeostasis GO:0030007 9.26 ATP4A ATP12A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP4A ATP12A
4 negative regulation of lipid storage GO:0010888 8.96 TNF CRP
5 leukocyte migration GO:0050900 8.92 TNF MMP9 F2 CEACAM5

Molecular functions related to Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
Sources

Sources for Hemorrhoid

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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