Hemorrhoid (PILES)

Categories: Cardiovascular diseases, Gastrointestinal diseases, Skin diseases
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Aliases & Classifications for Hemorrhoid

Summaries for Hemorrhoid

MedlinePlus: 41 What are hemorrhoids? Hemorrhoids are swollen, inflamed veins around your anus or the lower part of your rectum. There are two types: External hemorrhoids, which form under the skin around your anus Internal hemorrhoids, which form in the lining of your anus and lower rectum What causes hemorrhoids? Hemorrhoids happen when there is too much pressure on the veins around the anus. This can be caused by: Straining during bowel movements Sitting on the toilet for long periods of time Chronic constipation or diarrhea A low-fiber diet Weakening of the supporting tissues in your anus and rectum. This can happen with aging and pregnancy. Frequently lifting heavy objects What are the symptoms of hemorrhoids? The symptoms of hemorrhoids depend on which type you have: With external hemorrhoids, you may have: Anal itching One or more hard, tender lumps near your anus Anal pain, especially when sitting Too much straining, rubbing, or cleaning around your anus may make your symptoms worse. For many people, the symptoms of external hemorrhoids go away within a few days. With internal hemorrhoids, you may have: Bleeding from your rectum - you would see bright red blood in your stool, on toilet paper, or in the toilet bowl after a bowel movement Prolapse, which is a hemorrhoid that has fallen through your anal opening Internal hemorrhoids are usually not painful unless they are prolapsed. Prolapsed internal hemorrhoids may cause pain and discomfort. How can I treat hemorrhoids at home? You can most often treat your hemorrhoids at home by: Eating foods that are high in fiber Taking a stool softener or a fiber supplement Drinking enough fluids every day Not straining during bowel movements Not sitting on the toilet for long periods of time Taking over-the-counter pain relievers Taking warm baths several times a day to help relieve pain. This could be a regular bath or a sitz bath. With a sitz bath, you use a special plastic tub that allows you to sit in a few inches of warm water. Using over-the-counter hemorrhoid creams, ointments, or suppositories to relieve mild pain, swelling, and itching of external hemorrhoids When do I need to see a health care provider for hemorrhoids? You should see your health care provider if you: Still have symptoms after 1 week of at-home treatment Have bleeding from your rectum. Hemorrhoids are a common cause of bleeding, but other conditions can also cause bleeding. They include Crohn's disease, ulcerative colitis, colorectal cancer, and anal cancer. So it's important to see your provider to find the cause of the bleeding. How are hemorrhoids diagnosed? To make a diagnosis, your health care provider: Will ask about your medical history Will do a physical exam. Often providers can diagnose external hemorrhoids by looking at the area around your anus. Will do a digital rectal exam to check for internal hemorrhoids. For this, the provider will insert a lubricated, gloved finger into the rectum to feel for anything that is abnormal. May do procedures such as an anoscopy to check for internal hemorrhoids What are the treatments for hemorrhoids? If at-home treatments for hemorrhoids don't help you, you may need a medical procedure. There are several different procedures that your provider can do in the office. These procedures use different techniques to cause scar tissue to form in the hemorrhoids. This cuts off the blood supply, which usually shrinks the hemorrhoids. In severe cases, you may need surgery. Can hemorrhoids be prevented? You can help prevent hemorrhoids by: Eating foods that are high in fiber Taking a stool softener or a fiber supplement Drinking enough fluids every day Not straining during bowel movements Not sitting on the toilet for long periods of time NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary: Hemorrhoid, also known as hemorrhoids, is related to mucormycosis and internal hemorrhoid, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Hemorrhoid is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Menthol and Glycerin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and spinal cord, and related phenotypes are neoplasm and muscle

Disease Ontology: 11 A pelvic varices that is characterized by swollen, inflamed veins around the anus or lower rectum.

Wikipedia: 75 Hemorrhoids (or haemorrhoids), also known as piles, are vascular structures in the anal canal. In their... more...

Related Diseases for Hemorrhoid

Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1146)
# Related Disease Score Top Affiliating Genes
1 mucormycosis 31.6 TNF INS IL6 CRP
2 internal hemorrhoid 30.9 MLANA KRT7 KRT20 F2 CRP CEACAM5
3 proctitis 30.4 TNF KLK3 CRP
4 portal hypertension 30.4 TNF GPT F2 ALB
5 renal hypertension 30.3 INS CRP ALB
6 colorectal adenoma 30.2 IL6 CEACAM5 APC
7 giardiasis 30.2 ATP4A ATP12A ALB
8 dieulafoy lesion 30.2 F2 ATP4A ATP12A
9 varicose veins 30.2 TNF IL6 F2
10 varicocele 30.1 TNF IL6 ALB
11 intussusception 30.1 IL6 CRP CEACAM5 ALB
12 rectal disease 30.1 TNF KRT7 KLK3 IL6 IL1B GPT
13 bacteriuria 30.0 IL6 CRP ALB
14 thrombophlebitis 30.0 F3 F2 CRP ALB
15 irritable bowel syndrome 30.0 TNF IL6 IL1B CRP
16 post-traumatic stress disorder 30.0 IL6 IL1B CRP
17 hernia, hiatus 30.0 INS CRP ATP4A ATP12A ALB
18 dental caries 30.0 IL6 IL1B CRP ALB
19 common cold 29.9 TNF IL6 IL1B CRP
20 angiodysplasia 29.9 F3 F2 ATP4A ATP12A
21 tetanus 29.9 TNF IL6 IL1B CRP ALB
22 cervicitis 29.9 TNF IL6 IL1B
23 vaginitis 29.9 TNF IL6 IL1B
24 gastritis 29.8 TNF IL6 IL1B ATP4A
25 cholelithiasis 29.8 INS GPT CRP ALB
26 inflammatory bowel disease 1 29.8 TNF IL6 IL1B
27 gastroschisis 29.8 IL6 IL1B F2
28 gastroenteritis 29.8 TNF IL6 IL1B CRP ALB
29 crohn's disease 29.8 TNF IL6 IL1B CRP ALB
30 acquired immunodeficiency syndrome 29.8 TNF IL6 IL1B CRP ALB
31 viral infectious disease 29.8 TNF IL6 IL1B GPT
32 acute kidney failure 29.8 IL6 GPT F2 ALB
33 carbuncle 29.7 TNF IL6 IL1B ALB
34 urolithiasis 29.7 IL6 IL1B F2 ALB
35 spondylitis 29.7 TNF IL6 IL1B CRP
36 plague 29.7 TNF IL6 IL1B ALB
37 cavernous hemangioma 29.7 F3 F2 CEACAM5 ALB
38 rectal benign neoplasm 29.7 KRT7 KRT20 CEACAM5
39 diarrhea 29.7 TNF IL6 IL1B GPT ALB
40 arteriovenous malformation 29.7 F3 F2 ALB
41 pleural empyema 29.7 IL6 GPT F2 CRP ALB
42 hemolytic uremic syndrome, atypical 1 29.7 F3 F2 CRP ALB
43 paine syndrome 29.7 TNF IL6 IL1B ATP4A ATP12A
44 prostatitis 29.7 TNF KLK3 IL6 IL1B
45 pain agnosia 29.7 TNF INS IL6 IL1B CRP ALB
46 endocarditis 29.7 TNF IL6 F2 CRP ALB
47 aortic valve insufficiency 29.7 F3 F2 CRP ALB
48 bronchitis 29.6 TNF IL6 IL1B CRP ALB
49 cholera 29.6 TNF INS IL6 IL1B
50 nutritional deficiency disease 29.6 IL6 F2 CRP ATP4A ATP12A ALB

Graphical network of the top 20 diseases related to Hemorrhoid:

Diseases related to Hemorrhoid

Symptoms & Phenotypes for Hemorrhoid

UMLS symptoms related to Hemorrhoid:

nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; rectal tenesmus; heartburn; pruritus ani; gastrointestinal gas; rectal pain

MGI Mouse Phenotypes related to Hemorrhoid:

# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.86 ALB APC ATP4A CEACAM5 F3 IL1B
2 muscle MP:0005369 9.81 ALB APC CEACAM5 F2 F3 IL6
3 digestive/alimentary MP:0005381 9.65 ALB APC ATP12A ATP4A CEACAM5 F2
4 cardiovascular system MP:0005385 9.36 ALB APC CEACAM5 CRP F2 F3

Drugs & Therapeutics for Hemorrhoid

Drugs for Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 161)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Menthol Approved, Experimental Phase 4 1490-04-6, 2216-51-5, 15356-60-2 1254 16666 165675
Glycerin Approved, Investigational Phase 4 56-81-5 753
Borage oil Approved, Investigational Phase 4
Prilocaine Approved Phase 4 721-50-6 4906
Metronidazole Approved Phase 4 443-48-1, 69198-10-3 4173
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
Acetaminophen Approved Phase 4 103-90-2 1983
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Magnesium oxide Approved Phase 4 1309-48-4 14792
Magnesium hydroxide Approved, Investigational Phase 4 1309-42-8
Ibuprofen Approved Phase 4 15687-27-1 3672
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
Lactulose Approved Phase 4 4618-18-2 11333
Lecithin Approved, Experimental, Investigational, Nutraceutical Phase 4 8002-43-5, 1446756-47-3, 18656-38-7 26197 9547096 6323481
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
26 Aloe Phase 4
27 Devil's Claw Phase 4
28 Arnica Phase 4
29 Soy Bean Phase 4
30 Borage Phase 4
31 Gotu Kola Phase 4
32 Anti-Inflammatory Agents Phase 4
33 Anesthetics, General Phase 4
34 Anti-Bacterial Agents Phase 4
35 Anti-Infective Agents Phase 4
36 Antiprotozoal Agents Phase 4
37 Antiparasitic Agents Phase 4
38 Antirheumatic Agents Phase 4
39 Cyclooxygenase Inhibitors Phase 4
40 Anti-Inflammatory Agents, Non-Steroidal Phase 4
41 Analgesics, Non-Narcotic Phase 4
42 Calcium Dobesilate Phase 4
43 Cholinergic Agents Phase 4
abobotulinumtoxinA Phase 4
45 Botulinum Toxins, Type A Phase 4
46 Botulinum Toxins Phase 4
47 Excitatory Amino Acid Antagonists Phase 4
48 Anesthetics, Intravenous Phase 4
49 Anesthetics, Dissociative Phase 4
50 Cathartics Phase 4

Interventional clinical trials:

(show top 50) (show all 187)
# Name Status NCT ID Phase Drugs
1 Irritation and Anal Bleeding in Patients Affected by Hemorrhoids: Comparative Evaluation of Three Different Treatments. Unknown status NCT03569930 Phase 4 flavonoid-based supplements;Centella Complex
2 A Multicenter Prospective Clinical Study of Endoscopic Foam Sclerotherapy for Internal Hemorrhoids Unknown status NCT04398823 Phase 4 Sclerosing foam of Lauromacrogol;Sclersing liqiud of Lauromacrogol
3 Prospective and Randomized Trial Comparing Dopplper-Guided Transanal Hemorrhoid Artery Ligation With Recto-anal Repair (HAL-RAR) Versus Excisional Hemorrhoidectomy for the Treatment of Grade III-IV Hemorrhoids Unknown status NCT02216305 Phase 4
4 Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy: A Randomized Double-blind Controlled Trial Unknown status NCT01099605 Phase 4
5 A Comparative Clinical Research on Therapeutic Effect and Safety of Compound Carraghenates Cream Versus Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids Completed NCT01881282 Phase 4 Carraghenates Cream;Mayinglong Musk Hemorrhoid Ointment
6 Prospective Randomized Trial on Surgical Treatment of Grade 3 Hemorrhoids: Hemorrhoidectomy Versus Doppler-guided Transanal Haemorrhoidal Dearterialisation and Anopexy Completed NCT01263431 Phase 4
7 A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Versus Oral Metronidazole in Reducing Post-Operative Pain Following Excisional Haemorrhoidectomy Completed NCT03343509 Phase 4 Metronidazole Oral;Metronidazole Ointment;Placebo Oral Tablet;Placebo Ointment
8 Assessment of the Analgesic Efficacy of Morphine Chloride in Addition to a Low Dose Solution of Spinal Anaesthetic in Hemorrhoidectomy Compared to a Standard Dose of Spinal Local Anaesthetic. Simple Blind, Randomized, With Blinded Evaluation by Third Parties Clinical Trial. Completed NCT02046772 Phase 4 Bupivacaine low dose;Bupivacaine standard dose;Morphine Chloride
9 Double-blinded Multicenter Randomized Clinical Trial to Evaluate the Efficacy and Safety of CLIFE1 and CLIFE2 Gels in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
10 Symptom Control 1-year After Circular Stapler Anopey or Diathermy Excision for Prolapsed Haemorrhoids: an International Randomsed Trial (the STOPP-trial Completed NCT00841620 Phase 4
11 Calcium Dobesilate vs Flavonoids for the Treatment of Early Hemorrhoidal Disease a Randomised Triple Blind Controlled Trial Completed NCT02782455 Phase 4 Flavonoids;CDobi
12 Perianal Nerval Block in Proctological Interventions: a Prospective Randomized Double Blinded Study Completed NCT03405922 Phase 4 Placebo 40 mL Saline 0.9%;40 mL Ropivacain 0.5%
13 Effect of Perioperative i.v. Low-dose S(+) Ketamine in Patients Undergoing Hemorrhoidectomy Completed NCT00354029 Phase 4 S (+) Ketamine;Placebo
14 Randomized Clinical Trial of Botulinum Toxin Injection for Pain Relief in Patients With Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
15 The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
16 Comparing the Effects of Levobupivacaine and Bupivacaine in Anorectal Surgery Under Saddle Spinal Anesthesia Completed NCT04245774 Phase 4 Levobupivacaine (as Levobupivacaine Hydrochloride) 75 Mg/10 mL Solution for Injection Ampoule;Bupivacaine/Dextrose
17 Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial. Recruiting NCT04248205 Phase 4 Ketamine
18 Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery Recruiting NCT03738904 Phase 4
19 Evaluation of the Value of Perianal Infiltration During Thermodestruction of Haemorrhoidal Disease by Radiofrequency Not yet recruiting NCT05519189 Phase 4 Ropivacaine
20 An Open, Randomized, Parallel Group, Single Center Study to Investigate the Effect of Lactulose Versus Plantago Ovate on the Quality of Life of Patients With Hard Stools and Hemorrhoids or Anal Fissure Terminated NCT00160290 Phase 4 Lactulose;Plantago ovata
21 Comparison of Rectal Infiltration of Exparel vs. 0.25% Bupivacaine With Epinephrine vs. Placebo for Analgesic Benefit Following Hemorrhoidectomy Terminated NCT02104414 Phase 4 Exparel;Bupivacaine HCl with Epinephrine;Normal Saline
22 Multi-drug Analgesia Versus Standard Solution for Perianal Block - A Prospective Study to Determine the Efficacy, Cost and Narcotic Consumption in the Post-operative Period Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
23 Local vs General Anaesthesia in Stapled Hemorrhoidectomy: A Multicentric Controlled Randomized Trial Withdrawn NCT00512044 Phase 4
24 Topical Endorectal Vietamin E Ovules for the Treatment of Grade 2 and 3 Hemorrhoids Unknown status NCT04362384 Phase 3 Vitamin E ovules;Prednisolone ointment
25 Double Blinded Randomized Clinical Trial of the Efficacy of Topical 2% Lidocaine for the Treatment of Symptomatic Hemorrhoids Unknown status NCT01961739 Phase 2, Phase 3 2% lidocaine;placebo
26 Prospective Randomized Trial Comparing Transanal Doppler de-Arterialization (THD) Versus Stapler Operation for 3rd Degree Hemorrhoids Unknown status NCT00823784 Phase 3
27 Sclerotherapy With Polidocanol Foam In The Management Of First, Second And Third-Grade Hemorrhoidal Disease In Patients With Bleeding Disorders: A Prospective Cohort Study Unknown status NCT04188171 Phase 2, Phase 3
28 Clinical Efficacy and Safety Evaluation of the Drug Imescard Compound Water Smartweed Pills Unknown status NCT00861562 Phase 3 Imescard water smartweed composed pills;Placebo
29 Randomized Controlled Trials of Diet and Lifestyle Intervention to Promote Chinese Postpartum Women's Health Unknown status NCT01039051 Phase 2, Phase 3
30 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
31 Phase 3 Clinical Trial - Efficacy and Safety Evaluation of the Drug Imescard Compound Water Smartweed, Adrenalin and Hamamelis Ointment Unknown status NCT00935948 Phase 3 Imescard compound water smartweed ointment;Placebo
32 Topical Anesthesia Versus Placebo to Decrease Post Procedure Pain in Rubber Band Ligation for the Treatment of Grade I - III Symptomatic Internal Hemorrhoids. A Single Institution, Double Blinded, Placebo Controlled Trial. Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
33 A Prospective, Randomized, Three Arms, Open Label Study Comparing the Safety and Efficacy of Two Formulations of PP110 to the Active Comparator Preparation-H® Cream in the Treatment of Bleeding Hemorrhoids Grades 2-3 Completed NCT02010099 Phase 2, Phase 3 PP110 Gel;PP110 Medicated wipes;Preparation-H Cream
34 Phase 3, Multicenter, Randomized, Double-Blind, Parallel-group, Active-control Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy Completed NCT00744848 Phase 3 Bupivacaine HCl;SKY0402
35 A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Metronidazole, Diltiazem and Lidocaine on Post-Operative Pain Following Excisional Haemorrhoidectomy Completed NCT04276298 Phase 2, Phase 3 Metronidazole cream;Metronidazole and Diltiazem cream;Metronidazole and Lidocaine cream;Metronidazole, Diltiazem and Lidocaine cream
36 Sclerotherapy With Polidocanol Foam Versus Hemorrhoidal Artery Ligation With Recto Anal Repair in the Treatment of Second and Third-grade Hemorrhoidal Disease: a Prospective Study Completed NCT04675177 Phase 2, Phase 3 Polidocanol foam sclerotherapy
37 Effectiveness of Metronidazole Versus Homologated Placebo in Pain Control Posthemorrhoidectomy Completed NCT02328144 Phase 3 Metronidazole;Placebo
38 A Randomized, Placebo- and Benchmark-controlled, Double-blind Clinical Trial of Anusol Topical Ointment to Evaluate Symptom Relief in Patients With Haemorrhoids Completed NCT05157711 Phase 3 Anusol;Relief [Name];Placebo
39 Safety and Short Term Effectiveness of EEA Stapler vs PPH Stapler in the Treatment of III Degree Haemorrhoids. Prospective Randomized Controlled Trial Completed NCT01413867 Phase 3
40 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
41 A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy Completed NCT00890721 Phase 3 SKY0402;Placebo
42 A Randomised Controlled Trial Comparing Conventional Open Haemorrhoidectomy and Laser Haemorrhoidoplasty in the Treatment of Symptomatic Haemorrhoids: COHLAH Trial Recruiting NCT04329364 Phase 2, Phase 3
43 Assessment of Efficacy and Side Effects of Dlitiazem Ointment With Lidocaine vs. Diltiazem Ointment With Lidocaine for Treatment of Chronic Anal Fissure: Randomized Clinical Trial Not yet recruiting NCT04887818 Phase 2, Phase 3 2% Diltiazem ointment with 1.5% lidocaine;0.3% Nifedipine ointment with 1.5% lidocaine
44 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of Intra-Anal Application of Iferanserin (10 mg) as a 0.5% Ointment in Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
45 Double Blind Randomized Placebo-control Trial of Allium Ampeloprasum Spp.Iranicum Cream Effect for the Management of Hemorrhoids Symptoms Unknown status NCT02301052 Phase 1, Phase 2 Leek topical cream;placebo topical cream;Anti-hemorrhoid topical cream
46 Single Blind, Randomized Controlled, Multicenter Study to Evaluate the Efficacy and Convenience of Electronic Bidet With Very Low Force Flow Fountain System for Pain Control and Wound Healing After Operation for Anal Disease, Compared to Conventional Sitz Bath Unknown status NCT02353156 Phase 2
47 Is Greater Downstaging and Tumour Regression Observed When Surgery is Delayed to 12 Weeks After Completion of Chemoradiotherapy vs 6 Weeks? Unknown status NCT01037049 Phase 2
48 A Randomized, Double-Blind, Vehicle-Controlled, Multicenter Study to Evaluate Safety and Efficacy of Anucort HC TM (Hydrocortisone Acetate) 25mg Rectal Suppositories in the Treatment of Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
49 A Randomized, Dose-Ranging, Double Blind Study of Lidocaine Hydrochloride and/or Hydrocortisone Acetate (Alone or in Combination) in the 14-Day Twice-Daily Treatment of Grade I or II Hemorrhoids Completed NCT02689856 Phase 2 Hydrocortisone acetate and lidocaine hydrochloride;Placebo control;Hydrocortisone acetate;Lidocaine hydrochloride
50 A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel Group Study to Evaluate Safety and Efficacy of 25 mg Hydrocortisone Acetate Suppositories in the Treatment of Symptomatic Internal Hemorrhoids. Completed NCT03335774 Phase 2 Hydrocortisone Acetate Suppository, 25 mg (Nivagen);Placebo (Vehicle) Suppository (Nivagen)

Search NIH Clinical Center for Hemorrhoid

Inferred drug relations via UMLS 71 / NDF-RT 50 :

hydrocortisone acetate
Hydrocortisone butyrate
hydrocortisone cypionate
hydrocortisone probutate
Hydrocortisone sodium phosphate
Hydrocortisone sodium succinate
hydrocortisone valerate
Phenylephrine bitartrate
Phenylephrine Hydrochloride
Phenylephrine Tannate
Pramoxine hydrochloride
Witch Hazel

Cochrane evidence based reviews: hemorrhoids

Genetic Tests for Hemorrhoid

Anatomical Context for Hemorrhoid

Organs/tissues related to Hemorrhoid:

MalaCards : Skin, Kidney, Spinal Cord, Colon, Prostate, Liver, Smooth Muscle

Publications for Hemorrhoid

Articles related to Hemorrhoid:

(show top 50) (show all 5438)
# Title Authors PMID Year
Risk factors of delayed hemorrhage after LigaSure hemorrhoidectomy. 62 41
36229826 2022
36449865 2022
Study on time effect of residual pressure and bearing characteristics of jacked pile in saturated silt foundation. 41
36443442 2022
Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study. 62
36306933 2023
Cytotoxicity and antimicrobial activity of isolated compounds from Monsonia angustifolia and Dodonaea angustifolia. 62
35358625 2023
Effect of acetone fraction of Ottelia alismoides on the G2/M cell cycle arrest and apoptosis in the human carcinoma cell lines. 62
36162544 2023
Insights into the characteristics and mechanism of vacuum drying technology for municipal sludge processing. 62
36252900 2023
Ethnobotany, botany, phytochemistry and ethnopharmacology of the genus Thalictrum L. (Ranunculaceae): A review. 62
36470306 2022
Milligan-Morgan hemorrhoidectomy vs. hemorrhoid artery ligation and recto-anal repair: a comparative study. 62
36474223 2022
How to manage lower gastrointestinal bleeding in 2022? 62
36379842 2022
Laser hemorrhoidoplasty for hemorrhoidal disease: a systematic review and meta-analysis. 62
36094598 2022
Hemorrhoids and Hogwarts. 62
36194664 2022
Addition of carbon sources and nutrient salts can inhibit gangue acidification by changing microbial community structure. 62
35864391 2022
Cap-assisted endoscopic sclerotherapy is effective for rectal mucosal prolapse associated outlet obstructive constipation. 62
36379860 2022
Citroflavonoids as Promising Agents for Drug Discovery in Diabetes and Hypertension: A Systematic Review of Experimental Studies. 62
36432034 2022
Prevalent Technique and Results of Hemorrhoidal Embolization. 62
36431108 2022
The necessity of preoperative enema preparation for hemorrhoidal surgery: a single-center comparative study. 62
35729398 2022
Outcome of a modified Park's submucosal hemorrhoidectomy versus Milligan-Morgan for grade III-IV circumferential prolapsed hemorrhoids. 62
34840045 2022
The Phytochemical Profile and Biological Activity of Malva neglecta Wallr. in Surgically Induced Endometriosis Model in Rats. 62
36431970 2022
The impact of transvaginal, mesh-augmented level one apical repair on anorectal dysfunction due to pelvic organ prolapse. 62
35347368 2022
Topical Versus Oral Metronidazole After Excisional Hemorrhoidectomy: A Double-Blind Randomized Controlled Trial. 62
34897211 2022
[Expert consensus on clinical application of Fufang Jingjie for Fumigation and Washing]. 62
36472015 2022
Krimighna (anthelmintic) role of Neem Oil (medicated oil of Azadirachta indica Linn.) and adjuvant Ayurvedic therapies in the management of anal myiasis: A case report. 62
36399960 2022
The role of the Rafaelo procedure in the management of hemorrhoidal disease: a systematic review and meta-analysis. 62
36371772 2022
A case of acute superior mesenteric artery embolism caused by constipation after hemorrhoid surgery. 62
35644701 2022
Regional Differences in Procedural Care of Hemorrhoid Management in Medicare Patients; Unwarranted Variation in Clinical Practice for a Medical-First Problem. 62
36446250 2022
A Non-Flat Terrain Biped Gait Planner Based on DIRCON. 62
36412731 2022
Physico-chemical assessment of on-farm bioconversion of organic waste in dairy farms in context to sustainability and circular bioeconomy. 62
36377556 2022
Recurrence Rates and Pharmacological Treatment for Hemorrhoidal Disease: A Systematic Review. 62
36331754 2022
Emission of volatile sulphur compounds during swine manure composting: Source identification, odour mitigation and assessment. 62
36088860 2022
Rectal Artery Embolization for Hemorrhoidal Disease: Anatomy, Evaluation, and Treatment Techniques. 62
36318493 2022
i-CLIMATE: a "clinical climate informatics" action framework to reduce environmental pollution from healthcare. 62
35997550 2022
Sugar beet root storage properties are unaffected by Cercospora leaf spot. 62
36415894 2022
Core fungal species strengthen microbial cooperation in a food-waste composting process. 62
36157338 2022
Invited Commentary: Rectal Artery Embolization for Treatment of Symptomatic Hemorrhoidal Disease-Opportunity for Multidisciplinary Collaboration. 62
36190871 2022
Using Smartphones to Locate Trapped Victims in Disasters. 62
36236601 2022
Identifying important conceptual areas in a nursing education programme to meet future demands, using group concept mapping. 62
35932493 2022
Rectal Artery Embolization for Hemorrhoidal Disease: Anatomy, Evaluation, and Treatment Techniques. 62
36190848 2022
Hemorrhoid Disorder and Anal Intercourse: Is There a Solution? 62
35939158 2022
Clinical study of Huaiqin ointment in the treatment of anal edema after hemorrhoid operation. 62
34790930 2022
Long-term efficacy and safety of cap-assisted endoscopic sclerotherapy with long injection needle for internal hemorrhoids. 62
36386396 2022
What can patients expect in the long term from radiofrequency thermocoagulation of hemorrhoids on bleeding, prolapse, quality of life, and recurrence: "no pain, no gain" or "no pain but a gain"? 62
36217810 2022
ENSEAL® Hemorrhoidectomy, a Novel Technique, Versus Conventional Open Method for the Management of Grade III and IV Hemorrhoids. 62
36407175 2022
Prevalence of constipation in patients undergoing chemotherapy and the effect of constipation on quality of life. 62
35761103 2022
Water, Sanitation, and Hygiene Practices and Their Association With Childhood Diarrhoea in Rural Households of Mayurbhanj District, Odisha, India. 62
36348870 2022
The in vitro and in vivo antibacterial activities of uniflorous honey from a medicinal plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS. 62
35752262 2022
Most children experience resolution of idiopathic pediatric rectal prolapse with bowel management alone. 62
34872729 2022
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Variations for Hemorrhoid

Expression for Hemorrhoid

Search GEO for disease gene expression data for Hemorrhoid.

Pathways for Hemorrhoid

Pathways related to Hemorrhoid according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.24 KLK3 IL6 F2 ALB
Show member pathways
11.67 TNF IL1B F3
4 11.64 TNF IL6 IL1B
5 11.62 TNF IL6 IL1B
6 11.59 TNF IL6 CRP
Show member pathways
11.52 TNF IL6 IL1B
8 11.51 TNF IL6 IL1B
9 11.49 TNF IL6 IL1B
10 11.35 IL1B KLK3 TNF
11 11.33 TNF IL6 IL1B
12 11.3 TNF INS IL6
13 11.26 TNF IL6 IL1B
Show member pathways
11.21 INS F2 ALB
15 11.09 TNF IL6 IL1B
16 11 TNF IL6 IL1B
17 10.91 TNF IL6 IL1B
18 10.79 TNF IL6 IL1B
19 10.58 TNF IL6 IL1B
Show member pathways
10.21 TNF IL6
21 10.08 TNF IL6 CRP

GO Terms for Hemorrhoid

Cellular components related to Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.64 TNF KLK3 INS IL6 IL1B GPT

Biological processes related to Hemorrhoid according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.14 TNF IL6 IL1B CRP
2 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10 TNF IL6 F2
3 positive regulation of mitotic nuclear division GO:0045840 9.97 IL1B INS TNF
4 positive regulation of interleukin-8 production GO:0032757 9.97 TNF IL6 IL1B F3
5 negative regulation of neurogenesis GO:0050768 9.93 TNF IL6 IL1B
6 negative regulation of lipid catabolic process GO:0050995 9.91 IL1B INS TNF
7 positive regulation of glial cell proliferation GO:0060252 9.88 IL1B IL6 TNF
8 positive regulation of fever generation GO:0031622 9.85 TNF IL1B
9 sequestering of triglyceride GO:0030730 9.81 TNF IL1B
10 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.78 TNF IL1B
11 positive regulation of neuroinflammatory response GO:0150078 9.73 IL1B IL6 TNF
12 regulation of protein secretion GO:0050708 9.72 TNF KRT20 INS
13 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
14 acute-phase response GO:0006953 9.56 INS IL6 F2 CRP
15 vascular endothelial growth factor production GO:0010573 9.1 TNF IL6 IL1B

Molecular functions related to Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type potassium transmembrane transporter activity GO:0008556 8.96 ATP4A ATP12A
2 P-type potassium:proton transporter activity GO:0008900 8.92 ATP4A ATP12A

Sources for Hemorrhoid

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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