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MCID: HMR005
MIFTS: 51

Hemorrhoid

Categories: Cardiovascular diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hemorrhoid

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MalaCards integrated aliases for Hemorrhoid:

Name: Hemorrhoid 12 76 15
Hemorrhoids 43 44 73
Hemorrhoidal Disease 12
Rectal Diseases 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9746
ICD9CM 35 455
MeSH 44 D006484
NCIt 50 C26792
UMLS 73 C0019112
Sources

Summaries for Hemorrhoid

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MedlinePlus : 43 Hemorrhoids are swollen, inflamed veins around the anus or lower rectum. They are either inside the anus or under the skin around the anus. They often result from straining to have a bowel movement. Other factors include pregnancy, aging and chronic constipation or diarrhea. Hemorrhoids are very common in both men and women. About half of all people have hemorrhoids by age 50. The most common symptom of hemorrhoids inside the anus is bright red blood covering the stool, on toilet paper or in the toilet bowl. Symptoms usually go away within a few days. If you have rectal bleeding you should see a doctor. You need to make sure bleeding is not from a more serious condition such as colorectal or anal cancer. Treatment may include warm baths and a cream or other medicine. If you have large hemorrhoids, you may need surgery and other treatments. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hemorrhoid, also known as hemorrhoids, is related to internal hemorrhoid and spinal cord injury, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Endocytic Trafficking of EGFR and AGE/RAGE pathway. The drugs Lidocaine and Captopril have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related phenotypes are neoplasm and reproductive system

Disease Ontology : 12 A pelvic varix disease characterized by swollen, inflamed veins around the anus or lower rectum.

Wikipedia : 76 Hemorrhoids, also called piles, are vascular structures in the anal canal. In their normal state, they... more...

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Related Diseases for Hemorrhoid

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Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 internal hemorrhoid 33.5 MMP9 NOS2
2 spinal cord injury 29.1 MMP9 NOS2
3 perianal hematoma 11.5
4 varicose veins 11.2
5 constipation 11.2
6 rectal disease 11.2
7 anus disease 11.2
8 fecal incontinence 10.9
9 mycetoma 10.1 MMP9 NOS2
10 pelvic organ prolapse 10.0
11 coronary heart disease 1 9.9
12 heart disease 9.9
13 thrombosis 9.8
14 melanoma 9.8
15 proctitis 9.8
16 intestinal obstruction 9.8
17 radiation proctitis 9.8
18 colorectal cancer 9.7
19 renal cell carcinoma, nonpapillary 9.7
20 anus, imperforate 9.7
21 anal fistula 9.7
22 burns 9.7
23 hemangioma 9.7
24 mantle cell lymphoma 9.7
25 lymphoma 9.7
26 mucositis 9.7
27 portal hypertension 9.7
28 myiasis 9.7
29 tetanus 9.7
30 megacolon 9.7
31 urethritis 9.7
32 malignant anus melanoma 9.7
33 neuroendocrine tumor 9.7
34 angiodysplasia 9.7
35 endometriosis 9.7
36 cavernous hemangioma 9.7
37 anal neuroendocrine tumor 9.7
38 compartment syndrome 9.7
39 skin tag 9.7
40 peroneal nerve paralysis 9.7
41 thyroiditis 9.7
42 fournier gangrene 9.7
43 leukoplakia 9.7
44 coffin-lowry syndrome 9.5 RPS6KA1 RPS6KA3

Graphical network of the top 20 diseases related to Hemorrhoid:



Diseases related to Hemorrhoid
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Symptoms & Phenotypes for Hemorrhoid

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UMLS symptoms related to Hemorrhoid:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, rectal tenesmus, gastrointestinal gas, pruritus ani, rectal pain

MGI Mouse Phenotypes related to Hemorrhoid:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.46 MMP9 NOS2 RPS6KA3 SMAD9
2 reproductive system MP:0005389 9.35 KIAA1217 MMP9 NOS2 RPS6KA3 SMAD9
3 skeleton MP:0005390 9.02 KIAA1217 MMP9 NOS2 RPS6KA3 SMAD9
Sources

Drugs & Therapeutics for Hemorrhoid

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Drugs for Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 149)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 137-58-6 3676
2
Captopril Approved Phase 4 62571-86-2 44093
3
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
4
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
5
Nitrendipine Approved, Investigational Phase 4 39562-70-4 4507
6
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 51-43-4 5816
7
Racepinephrine Approved Phase 4,Phase 3,Not Applicable 329-65-7 838
8
Acetylcholine Approved Phase 4 51-84-3 187
9
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
10
Ketamine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 6740-88-1 3821
11
Morphine Approved, Investigational Phase 4 57-27-2 5288826
12
Metronidazole Approved Phase 4,Phase 3 443-48-1 4173
13
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
15
Prilocaine Approved Phase 4,Phase 3 721-50-6 4906
16
Lactulose Approved Phase 4 4618-18-2 11333
17 calcium channel blockers Phase 4,Not Applicable
18 diuretics Phase 4
19
protease inhibitors Phase 4,Not Applicable
20 Respiratory System Agents Phase 4,Phase 2,Phase 3,Not Applicable
21 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
22 Adjuvants, Anesthesia Phase 4,Not Applicable
23 Cholinergic Agents Phase 4,Not Applicable
24 Mydriatics Phase 4,Phase 2,Phase 3,Not Applicable
25 Natriuretic Agents Phase 4
26 Sodium Channel Blockers Phase 4,Phase 2,Phase 3
27 Sodium Chloride Symporter Inhibitors Phase 4
28 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
29 HIV Protease Inhibitors Phase 4,Not Applicable
30 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
31 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
32 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3
33 Angiotensin-Converting Enzyme Inhibitors Phase 4
34 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Not Applicable
35 Vasodilator Agents Phase 4
36 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
37 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
38 Epinephryl borate Phase 4,Phase 3,Not Applicable
39 Pharmaceutical Solutions Phase 4,Not Applicable
40 Antihypertensive Agents Phase 4
41 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
42 Bronchodilator Agents Phase 4,Phase 3,Not Applicable
43 Calcium, Dietary Phase 4,Not Applicable
44 Analgesics Phase 4,Phase 2,Not Applicable,Early Phase 1
45 abobotulinumtoxinA Phase 4
46 Adrenergic Agents Phase 4,Phase 2,Phase 3
47 Adrenergic Agonists Phase 4,Phase 2,Phase 3
48 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3
49 Adrenergic beta-Agonists Phase 4,Phase 3
50 Gastrointestinal Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
2 Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy Unknown status NCT01099605 Phase 4
3 Treatment of Hypertension in Tibetan Adult Population Unknown status NCT02217852 Phase 4 Nitrendipine;Hydrochlorothiazide;Captopril,Hydrochlorothiazide;Beijing hypotensive No.0
4 A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids Completed NCT01881282 Phase 4 Carraghenates Cream;Mayinglong Musk Hemorrhoid Ointment
5 Pain Relief for Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
6 Symptom Control 1-year After Circular Stapler Anopexy or Diathermy Excision for Prolapsed Haemorhoids Completed NCT00841620 Phase 4
7 Comparison Between Excisional Hemorrhoidectomy and Haemorrhoidal Dearterialisation With Anopexy Completed NCT01263431 Phase 4
8 Safety and Efficacy of the Addition of Morphine Chloride to a Low Dose of Bupivacaine as Intradural Anaesthetic for the Removal Surgery of the Hemorrhoids Completed NCT02046772 Phase 4 Bupivacaine low dose;Bupivacaine standard dose;Morphine Chloride
9 Effect of Perioperative i.v. Low-dose S(+) Ketamine Completed NCT00354029 Phase 4 S (+) Ketamine;Placebo
10 Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
11 Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
12 Irritation and Anal Bleeding in Patients Affected by Hemorrhoids. Recruiting NCT03569930 Phase 4 flavonoid-based supplements;Centella Complex
13 Calcium Dobesilate vs Flavonoids for the Treatment of Early Hemorrhoidal Disease Recruiting NCT02782455 Phase 4 Flavonoids;CDobi
14 Perianal Nerval Block in Proctological Interventions Recruiting NCT03405922 Phase 4 Placebo 40 mL Saline 0.9%;40 mL Ropivacain 0.5%
15 Topical Versus Oral Metronidazole Following Excisional Haemorrhoidectomy Not yet recruiting NCT03343509 Phase 4 Metronidazole Oral;Metronidazole Ointment;Placebo Oral Tablet;Placebo Ointment
16 Trial to Evaluate Effect of Lactulose on Hard Stools in Patients With Hemorrhoids or Anal Fissures Terminated NCT00160290 Phase 4 Lactulose;Plantago ovata
17 Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy Terminated NCT02104414 Phase 4 Exparel;Bupivacaine HCl with Epinephrine;Normal Saline
18 Local Versus General Anaesthesia in Stapled Hemorrhoidectomy Withdrawn NCT00512044 Phase 4
19 Multi-Drug Analgesia vs. Standard Solution for Anal Surgery Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
20 Hepatitis C Virus Post-Exposure Prophylaxis for Health Care Workers Withdrawn NCT01766115 Phase 4 Telaprevir
21 Topical 2% Lidocaine for the Treatment of Symptomatic Hemorrhoids Unknown status NCT01961739 Phase 2, Phase 3 2% lidocaine;placebo
22 Prospective Randomized Trial Comparing THD Versus Stapler Operation for 3rd Degree Hemorrhoids Unknown status NCT00823784 Phase 3
23 Clinical Efficacy and Safety Evaluation of the Drug Imescard Compound Water Smartweed Pills Unknown status NCT00861562 Phase 3 Imescard water smartweed composed pills;Placebo
24 Efficacy and Tolerability of the Use of Varicell Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
25 Efficacy and Safety Evaluation of the Imescard Compound Water Smartweed Ointment Unknown status NCT00935948 Phase 3 Imescard compound water smartweed ointment;Placebo
26 Diet and Lifestyle Intervention Study in Postpartum Women in China Unknown status NCT01039051 Phase 2, Phase 3
27 Safety and Short Term Effectiveness of EEA Versus PPH Stapler for III Degree Hemorrhoids Completed NCT01413867 Phase 3
28 Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
29 A Prospective, Randomized, Three Arms, Open Label Study Comparing the Safety and Efficacy of Two Formulations of PP110 to the Active Comparator Preparation-H® Cream in the Treatment of Bleeding Hemorrhoids Grades 2-3 Completed NCT02010099 Phase 2, Phase 3 PP110 Gel;PP110 Medicated wipes;Preparation-H Cream
30 Study About Patient Comfort and Long-term Outcome After Stapled Hemorrhoidopexy Completed NCT01533363 Phase 3
31 Study of Pain Control in Hemorrhoidectomy Completed NCT00890721 Phase 3 SKY0402;Placebo
32 Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy Completed NCT00744848 Phase 3 Bupivacaine HCl;SKY0402
33 Effectiveness of Metronidazole in Pain Control Posthemorrhoidectomy Completed NCT02328144 Phase 3 Metronidazole;Placebo
34 Randomized Controlled Trial Comparing Transanal Doppler-guided Arterial Ligation With Mucopexy and Stapled Haemorrhoidopexy Completed NCT01240772 Phase 3
35 Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
36 Evaluation of Allium Ampeloprasum Spp.Iranicum Cream Effect for the Management of Hemorrhoids Symptoms Unknown status NCT02301052 Phase 1, Phase 2 Leek topical cream;placebo topical cream;Anti-hemorrhoid topical cream
37 Efficacy Study of Iferanserin to Treat Hemorrhoids Completed NCT01483833 Phase 2 Iferanserin;Placebo
38 To Evaluate the Dose Response of 3 Doses of Euphorbia Prostrata in Patients With First and Second Degree Hemorrhoids Completed NCT01041911 Phase 2 Euphorbia tablets;Euphorbia tablets;Euphorbia tablets;Placebo tablets
39 Safety and Efficacy of Hydrocortisone and Lidocaine Treatment of Grade I and II Hemorrhoids Completed NCT02689856 Phase 2 Hydrocortisone acetate and lidocaine hydrochloride;Placebo control;Hydrocortisone acetate;Lidocaine hydrochloride
40 Safety and Efficacy Study of Anucort HC TM 25mg Rectal Suppositories to Treat Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
41 Study of a New Circular Anal Dilator Completed NCT00693459 Phase 1, Phase 2
42 Ticagrelor and Eptifibatide Bolus-Only Versus Ticagrelor and Eptifibatide Bolus Plus Abbreviated Infusion Completed NCT01919723 Phase 2 Ticagrelor;Eptifibatide
43 Occupational Therapy Modulates the Pain in Cancer Patient Under Palliative Care Completed NCT02102178 Phase 2
44 Efficacy and Safety of Armodafinil as Adjunctive Therapy in Schizophrenic Adults With Cognitive Deficits Completed NCT00487942 Phase 2 armodafinil;armodafinil;armodafinil;placebo
45 Posthemorrhoidectomy Pain Management With Electronic Bidet or Sitz Bath Enrolling by invitation NCT02353156 Phase 2
46 Study of the Safety and Efficacy of Hydrocortisone Acetate Suppositories, 25 mg in the Treatment of Symptomatic Internal Hemorrhoids Not yet recruiting NCT03335774 Phase 2 Hydrocortisone Acetate Suppository, 25 mg;Placebo (Vehicle) Suppository
47 Consolidation Therapy With Hu3S193 for Women With Ovarian, Primary Peritoneal or Fallopian Tube Cancer Terminated NCT01137071 Phase 2
48 Prevention and/or Reduction of Hemorrhoids and/or Thrombosed External Hemorrhoids Using the HEM-AVERT Perianal Stabilizer Instrument Completed NCT00487045 Phase 1
49 HET Bipolar System: Validation of Outpatient Hemorrhoid Treatment Unknown status NCT02773420 Not Applicable
50 The Relationship Between Haemorrhoids and Pelvic Vein Reflux Unknown status NCT02039570

Search NIH Clinical Center for Hemorrhoid

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hemorrhoids

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Genetic Tests for Hemorrhoid

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Anatomical Context for Hemorrhoid

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MalaCards organs/tissues related to Hemorrhoid:

41
Skin, Kidney, Testes, Brain, Bone, Heart, Liver
Sources

Publications for Hemorrhoid

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Articles related to Hemorrhoid:

(show top 50) (show all 126)
# Title Authors Year
1
Traditional and modern aspects of hemorrhoid treatment in Iran: a review. ( 29526242 )
2018
2
Endometriosis in the rectum accompanied by hemorrhoids leading to diagnostic pitfalls: a rare case report. ( 29973210 )
2018
3
Hemorrhoid, External ( 29763185 )
2018
4
The Clinical Efficacy of Infrared Photocoagulation Versus Closed Hemorrhoidectomy in Treatment of Hemorrhoid. ( 29399307 )
2018
5
Novel Nonsurgical Treatment of Intractable Bleeding in Hemorrhoid Patients on Anticoagulants. ( 29774789 )
2018
6
Hemorrhoid is associated with increased risk of peripheral artery occlusive disease: A nationwide cohort study. ( 28268046 )
2017
7
Association between hemorrhoid and risk of coronary heart disease: A nationwide population-based cohort study. ( 28767586 )
2017
8
Anal Melanoma in an Elderly Woman Masquerading as Hemorrhoid. ( 29387509 )
2017
9
Twenty Years of a Veterans' Spinal Cord Injury Colorectal Clinic: Flexible Sigmoidoscopy and Multiple Hemorrhoid Ligation. ( 28267007 )
2017
10
Selective embolization of the superior rectal artery: An alternative to hemorrhoid surgery? ( 29042023 )
2017
11
The Use of Fluorescence Angiography for Confirmation of Hemorrhoid Dearterialization. ( 28822382 )
2017
12
Anal Neuroendocrine Tumor Masquerading as External Hemorrhoids: A Case Report. ( 28270879 )
2017
13
Hemorrhoid Treatment Needs a Relook: More Room for Conservative Management Even in Advanced Grades of Hemorrhoids. ( 29217916 )
2017
14
Intestinal obstruction following a hemorrhoid laser procedure (HeLP). ( 27573196 )
2016
15
Hemorrhoid cushions for chondrodermatitis nodularis helicis (CNH): Piling off the pressure. ( 27444092 )
2016
16
OS 22-04 Impact of Hemorrhoid on Coronary Heart Disease Development with or without Concomitant Comorbidities: A Population Based Cohort Study. ( 27643033 )
2016
17
Biological findings from the PheWAS catalog: focus on connective tissue-related disorders (pelvic floor dysfunction, abdominal hernia, varicose veins and hemorrhoids). ( 27126235 )
2016
18
Colorectal cancer implant in an external hemorrhoidal skin tag. ( 27034567 )
2016
19
OS 22-04 Impact of Hemorrhoid on Coronary Heart Disease Development with or without Concomitant Comorbidities: A Population Based Cohort Study. ( 27754108 )
2016
20
Transanal hemorrhoid dearterialization is a safe and effective outpatient procedure for the treatment of hemorrhoidal disease. ( 27771095 )
2016
21
Intestinal obstruction requiring fecal diversion due to rectal hematoma following a hemorrhoid laser procedure (HeLP). ( 27189441 )
2016
22
Review of Hemorrhoid Disease: Presentation and Management. ( 26929748 )
2016
23
The Use of Transanal Hemorrhoidal Dearterialization for Treatment of Hemorrhoid Disease at a Single Institution. ( 28234178 )
2016
24
Hemorrhoid laser procedure for second- and third-degree hemorrhoids: results from a multicenter prospective study. ( 27164931 )
2016
25
Complete rectal prolapse vs prolapsed hemorrhoids: points to ponder. ( 27642427 )
2016
26
Rectal arterio-venous malformation (AVM) with bleeding of an internal hemorrhoid. ( 26879656 )
2016
27
A technical note regarding hemorrhoid banding. ( 26934458 )
2016
28
Psychodynamic and biodynamic analysis of treatment of outlet obstructive constipation (OOC) using Procedure for Prolapse and Hemorrhoids (PPH). ( 25892490 )
2015
29
Hemorrhoid, internal iliac vein reflux and peripheral varicose vein: Affecting each other or affected vessels? ( 25527517 )
2015
30
Clinical Outcome Following Hemorrhoid Surgery: a Narrative Review. ( 27011555 )
2015
31
Beneficial effects of Flavonoids after ambulatory therapy with Combined Hemorrhoidal Radiocoagulation (CHR). ( 25720723 )
2015
32
Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease. ( 26316703 )
2015
33
Hemorrhoid veins, the forgotten realm of the vascular surgeon. ( 26993194 )
2014
34
Perianal mantle cell lymphoma mimicking an external thrombosed hemorrhoid: a case report. ( 24499548 )
2014
35
Iatrogenic rectal diverticulum with pelvic-floor dysfunction in patients after a procedure for a prolapsed hemorrhoid. ( 24639972 )
2014
36
THD Doppler procedure for hemorrhoids: the surgical technique. ( 24026315 )
2014
37
Pyogenic liver abscess as a complication of internal hemorrhoid banding. ( 24480193 )
2014
38
Benign tailgut cyst masquerading as a hemorrhoid. ( 24729989 )
2014
39
Distal Hemorrhoidectomy With ALTA Injection: A New Method for Hemorrhoid Surgery. ( 24833156 )
2014
40
A prospective, randomized trial comparing the short- and long-term results of doppler-guided transanal hemorrhoid dearterialization with mucopexy versus excision hemorrhoidectomy for grade III hemorrhoids. ( 24509458 )
2014
41
Anorectal malignant melanoma in a hemorrhoidal nodule: a diagnostic and therapeutic problem. ( 24221054 )
2013
42
Pneumoretroperitoneum after procedure for prolapsed hemorrhoid. ( 24466542 )
2013
43
Rectal perforation caused by anal stricture after hemorrhoid treatment. ( 23586012 )
2013
44
Self-help steps to get through hemorrhoid flare-ups. Half of us develop hemorrhoids in our lifetimes, but these easy remedies help to soothe while you heal. ( 24396896 )
2013
45
Letter to the editor concerning: Hawkins M, Billingham R, Bastawrous A. Hemorrhoid management in patients with radiation proctitis. Int J Colorectal Dis. 2012 Jun 20. [Epub ahead of print]. ( 23011547 )
2013
46
Hemorrhoid management in patients with radiation proctitis. ( 22714783 )
2012
47
Intra-anal Iferanserin 10 mg BID for hemorrhoid disease: a prospective, randomized, double-blind, placebo-controlled trial. ( 22244049 )
2012
48
Unilateral mydriasis due to hemorrhoidal ointment. ( 19596177 )
2012
49
Randomized trial of the hemorrhoid laser procedure vs rubber band ligation: 6-month follow-up. ( 22426277 )
2012
50
Doppler-guided hemorrhoid artery ligation with Recto-Anal-Repair modification: functional evaluation and safety assessment of a new minimally invasive method of treatment of advanced hemorrhoidal disease. ( 22547979 )
2012
Sources

Variations for Hemorrhoid

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Expression for Hemorrhoid

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Search GEO for disease gene expression data for Hemorrhoid.
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Pathways for Hemorrhoid

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Pathways related to Hemorrhoid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Endocytic Trafficking of EGFR 64
Show member pathways
 11.21 RPS6KA1 RPS6KA3
2
AGE/RAGE pathway 1
11.08 MMP9 NOS2
3
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.96 MMP9 NOS2
4
FGF signaling pathway 1
10.63 MMP9 RPS6KA1
5
Melanocyte Development and Pigmentation 64
10.24 RPS6KA1 RPS6KA3
Sources

GO Terms for Hemorrhoid

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Biological processes related to Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell growth GO:0030307 9.32 RPS6KA1 RPS6KA3
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.26 RPS6KA1 RPS6KA3
3 positive regulation of cell differentiation GO:0045597 9.16 RPS6KA1 RPS6KA3
4 regulation of DNA-templated transcription in response to stress GO:0043620 8.96 RPS6KA1 RPS6KA3
5 regulation of translation in response to stress GO:0043555 8.62 RPS6KA1 RPS6KA3

Molecular functions related to Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 8.96 RPS6KA1 RPS6KA3
2 ribosomal protein S6 kinase activity GO:0004711 8.62 RPS6KA1 RPS6KA3
Sources

Sources for Hemorrhoid

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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