MCID: HNC001
MIFTS: 47

Henoch-Schoenlein Purpura

Categories: Rare diseases, Immune diseases, Blood diseases, Cardiovascular diseases

Aliases & Classifications for Henoch-Schoenlein Purpura

MalaCards integrated aliases for Henoch-Schoenlein Purpura:

Name: Henoch-Schoenlein Purpura 12 15 73
Henoch-Schonlein Purpura 12 53 55
Purpura, Schoenlein-Henoch 44
Purpura, Schonlein-Henoch 53
Henoch-Sch@nlein Purpura 12
Henoch Schonlein Purpura 53
Henoch-Schnlein Purpura 12
Henoch-Scholein Purpura 12
Anaphylactoid Purpura 53
Purpura, Autoimmune 12
Autoimmune Purpura 12
Allergic Purpura 12
Vascular Purpura 53

Classifications:



External Ids:

Disease Ontology 12 DOID:11123
ICD10 33 D69.0
ICD9CM 35 287.0
MeSH 44 D011695
NCIt 50 C34963
UMLS 73 C0034152

Summaries for Henoch-Schoenlein Purpura

NIH Rare Diseases : 53 Henoch-Schonlein purpura (HSP) is a disease that involves purple spots on the skin (purpura), joint pain, digestive problems, and glomerulonephritis (a type of kidney disorder). While the cause of this condition is not fully understood, it may develop as an immune response to an infection. HSP is usually seen in children, but it may affect people of any age. Most cases go away on their own without treatment. For those cases which require treatment, the main goal is to relieve symptoms such as joint pain, abdominal pain, or swelling. In many cases, over-the-counter medicines can be used. In some patients with severe arthritis, prednisone, a steroid medicine, may be prescribed.

MalaCards based summary : Henoch-Schoenlein Purpura, also known as henoch-schonlein purpura, is related to rapidly progressive glomerulonephritis and crescentic glomerulonephritis. An important gene associated with Henoch-Schoenlein Purpura is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Prednisone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and t cells, and related phenotype is immune system.

Related Diseases for Henoch-Schoenlein Purpura

Diseases related to Henoch-Schoenlein Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 30.6 CD79A ICAM1 MPO
2 crescentic glomerulonephritis 30.5 ICAM1 MPO VCAM1
3 vasculitis 28.7 CD40LG CD79A ICAM1 MEFV MPO VCAM1
4 glomerulonephritis 28.0 C3 CD40LG CD79A ICAM1 MPO VCAM1
5 systemic lupus erythematosus 27.7 C3 CD40LG CD79A ICAM1 MPO VCAM1
6 hypersensitivity vasculitis 27.4 C3 CD40LG CD79A HSP90AA1 MEFV MPO
7 thrombocytopenic purpura, autoimmune 12.4
8 immunoglobulin a vasculitis 11.4
9 immunodeficiency, common variable, 8, with autoimmunity 11.1
10 thrombocytopenia due to platelet alloimmunization 11.1
11 purpura 11.0
12 goodpasture syndrome 10.7 CD79A MPO
13 lymphocytic vasculitis 10.7 ICAM1 VCAM1
14 cortical thymoma 10.7 ICAM1 VCAM1
15 mooren's ulcer 10.7 ICAM1 VCAM1
16 hymenolepiasis 10.7 CD79A ICAM1
17 subendocardial myocardial infarction 10.6 ICAM1 VCAM1
18 actinic prurigo 10.6 ICAM1 VCAM1
19 amebiasis 10.6 CD79A ICAM1
20 rheumatoid vasculitis 10.6 ICAM1 VCAM1
21 anisakiasis 10.6 CD79A RNASE3
22 limbal stem cell deficiency 10.6 ICAM1 VCAM1
23 ulcerative stomatitis 10.6 CD79A MPO
24 cow milk allergy 10.6 CD79A RNASE3
25 shwartzman phenomenon 10.5 ICAM1 VCAM1
26 gastrointestinal allergy 10.5 CD79A RNASE3
27 selective igg deficiency disease 10.5 CD40LG CD79A
28 erythema multiforme 10.5 CD79A ICAM1
29 c1q nephropathy 10.5 CD40LG CD79A
30 meningovascular neurosyphilis 10.5 CD40LG CD79A
31 alpha chain disease 10.5 CD40LG CD79A
32 brill-zinsser disease 10.5 CD40LG CD79A
33 exudative glomerulonephritis 10.5 CD40LG CD79A
34 cork-handlers' disease 10.5 CD40LG CD79A
35 salpingo-oophoritis 10.5 CD40LG CD79A
36 early yaws 10.5 CD40LG CD79A
37 ventilation pneumonitis 10.5 CD40LG CD79A
38 axillary adenitis 10.5 CD40LG CD79A
39 cryofibrinogenemia 10.5 CD40LG CD79A
40 trichostrongyloidiasis 10.5 CD40LG CD79A
41 subacute bacterial endocarditis 10.5 CD40LG CD79A
42 immunoglobulin g deficiency 10.5 CD40LG CD79A
43 orbital granuloma 10.5 CD40LG CD79A
44 epidermolysis bullosa acquisita 10.5 CD79A HSP90AA1
45 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
46 hyperglobulinemic purpura 10.5 CD40LG CD79A
47 gastroduodenitis 10.5 CD40LG CD79A
48 bacterial conjunctivitis 10.5 CD40LG CD79A
49 heavy chain disease 10.5 CD40LG CD79A
50 ophthalmia neonatorum 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Henoch-Schoenlein Purpura:



Diseases related to Henoch-Schoenlein Purpura

Symptoms & Phenotypes for Henoch-Schoenlein Purpura

MGI Mouse Phenotypes related to Henoch-Schoenlein Purpura:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 C3 CD40LG CD79A HSP90AA1 ICAM1 LTC4S

Drugs & Therapeutics for Henoch-Schoenlein Purpura

Drugs for Henoch-Schoenlein Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 53-03-2 5865
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 83-43-2 6741
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
4
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-24-8 5755
5
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
6 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
7 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Not Applicable
8 Calcineurin Inhibitors Phase 4,Not Applicable
9 glucocorticoids Phase 4,Phase 2,Not Applicable
10 Hormone Antagonists Phase 4,Phase 2,Not Applicable
11 Hormones Phase 4,Phase 2,Not Applicable
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
13 Immunosuppressive Agents Phase 4,Phase 2,Not Applicable
14 Antiemetics Phase 4,Phase 2,Not Applicable
15 Antifungal Agents Phase 4,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
17 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
18 Autonomic Agents Phase 4,Phase 2,Not Applicable
19 Cyclosporins Phase 4,Not Applicable
20 Dermatologic Agents Phase 4,Not Applicable
21 Gastrointestinal Agents Phase 4,Phase 2,Not Applicable
22 Methylprednisolone acetate Phase 4,Phase 2,Not Applicable
23 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Not Applicable
24 Neuroprotective Agents Phase 4,Phase 2,Not Applicable
25 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
26 Prednisolone acetate Phase 4,Phase 2,Not Applicable
27 Prednisolone hemisuccinate Phase 4,Phase 2,Not Applicable
28 Prednisolone phosphate Phase 4,Phase 2,Not Applicable
29 Protective Agents Phase 4,Phase 2,Not Applicable
30 Omega 3 Fatty Acid Nutraceutical Phase 4
31
Cyclophosphamide Approved, Investigational Phase 2,Not Applicable 50-18-0, 6055-19-2 2907
32
Mycophenolate mofetil Approved, Investigational Phase 2,Not Applicable 128794-94-5 5281078
33
Mycophenolic acid Approved Phase 2,Not Applicable 24280-93-1 446541
34
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
35
Benazepril Approved, Investigational Phase 2 86541-75-5 5362124
36
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
37
Azathioprine Approved Phase 2 446-86-6 2265
38
Colchicine Approved Phase 2 64-86-8 6167 2833
39
Dapsone Approved, Investigational Phase 2 80-08-0 2955
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
41
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
42 Antibodies Phase 2
43 Immunoglobulins Phase 2
44 Alkylating Agents Phase 2,Not Applicable
45 Antineoplastic Agents, Alkylating Phase 2,Not Applicable
46 Anti-Bacterial Agents Phase 2,Not Applicable
47 Antibiotics, Antitubercular Phase 2,Not Applicable
48 Antitubercular Agents Phase 2,Not Applicable
49 BB 1101 Phase 2
50 Dexamethasone acetate Phase 2 1177-87-3

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
2 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
3 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
4 Research on the Blood- Cooling - Toxin - Removing - Stasis - Dispersing Protocol Evaluation of Hench-schonlein Purpura Unknown status NCT01104428 Phase 2 Placebo;"ziying" granules
5 The Research of Standard Diagnosis and Treatment for Severe HSP in Children Recruiting NCT02540720 Phase 2 Dexamethasone;Gamma globulin
6 The Research of Standard Diagnosis and Treatment for HSPN in Children Recruiting NCT02532777 Phase 2 Prednisone;Cyclophosphamide(CTX);Mycophenolate mofetil(MMF);Leflunomide(LEF);Angiotensin-converting enzyme inhibitor(ACEI);Methylprednisolone
7 The Research of Standard Diagnosis and Treatment for HSPN With Mild Proteinuria in Children Recruiting NCT02532790 Phase 2 Prednisone;ACEI
8 A Randomized Multicenter Study for Isolated Skin Vasculitis Recruiting NCT02939573 Phase 2 Colchicine;Dapsone;Azathioprine
9 Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura Unknown status NCT01610830
10 Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis Unknown status NCT02811770
11 IgA-positive Versus IgA-negative Immune Complex Vasculitis Unknown status NCT01815190
12 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
13 Efficacy of Steroid Versus Steroid Plus Cyclophosphamide for Severe Henoch-Schoenlein Purpura Completed NCT00190229 Not Applicable Cyclophosphamide
14 Mycophenolate Mofetil (MMF) Versus Intravenous CTX Pulses in the Treatment of Adult Severe HSPN Completed NCT00301613 Not Applicable Mycophenolate mofetil
15 Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies. Completed NCT01715623
16 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
17 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
18 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
19 Impact of Vasculitis on Employment and Income Completed NCT02476292
20 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
21 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
22 Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura Recruiting NCT02317133
23 VCRC Tissue Repository Recruiting NCT02967068
24 Vasculitis Pregnancy Registry Recruiting NCT02593565
25 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Recruiting NCT02374450 Not Applicable
26 Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis Enrolling by invitation NCT02878018 Qi-Ji Shen-Kang formula; Zhu-Bai formula; Yu-Shen formula;angiotensin-converting enzyme (ACE) inhibitor; adrenergic receptor binder (ARB); adrenal cortical hormone; Tripterygium wilfordii polyglycosidium; immunosuppressant

Search NIH Clinical Center for Henoch-Schoenlein Purpura

Cochrane evidence based reviews: purpura, schoenlein-henoch

Genetic Tests for Henoch-Schoenlein Purpura

Anatomical Context for Henoch-Schoenlein Purpura

MalaCards organs/tissues related to Henoch-Schoenlein Purpura:

41
Skin, Kidney, T Cells, Colon, B Cells, Monocytes

Publications for Henoch-Schoenlein Purpura

Articles related to Henoch-Schoenlein Purpura:

(show top 50) (show all 71)
# Title Authors Year
1
A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. ( 27030970 )
2016
2
Screening of celiac disease in children with Henoch-Schoenlein purpura. ( 26792132 )
2016
3
Plasma gelsolin as a potential biomarker for Henoch- Schoenlein purpura. ( 27575439 )
2016
4
Application value of laboratory indexes in the differential diagnosis of Henoch-Schoenlein purpura. ( 27444626 )
2016
5
Clinico-pathological association of Henoch-Schoenlein purpura nephritis and IgA nephropathy in children. ( 26045740 )
2015
6
HLA-B35, a common genetic trait, in a familial case of Henoch-Schoenlein purpura and Berger's disease. ( 24782055 )
2014
7
Expression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients. ( 23795260 )
2013
8
Gastrointestinal manifestations of Henoch-Schoenlein purpura. ( 22451115 )
2013
9
Association of henoch-schoenlein purpura with hepatitis a. ( 23429757 )
2012
10
Methylprednisolone pulse plus mizoribine in children with Henoch-Schoenlein purpura nephritis. ( 20844911 )
2011
11
Predictive factor of severe renal involvement in children with Henoch-Schoenlein purpura. ( 22043777 )
2011
12
Re: steroids in haemorrhagic bullous Henoch-Schoenlein purpura. ( 21129013 )
2011
13
Systemic lupus erythematosus with severe nephritis that mimicked Henoch-Schoenlein purpura. ( 22026341 )
2011
14
A case of Henoch-Schoenlein purpura nephritis recurring after 3 years remission. ( 21485656 )
2010
15
MPO-ANCA- and IgA-positive systemic vasculitis: a possibly overlapping syndrome of microscopic polyangiitis and Henoch-Schoenlein purpura. ( 19586496 )
2009
16
[Relationship between leukotrienes and clinical, pathological features of Henoch-Schoenlein purpura nephritis in children]. ( 19099729 )
2008
17
Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis. ( 17347555 )
2007
18
Cardiac manifestations of Henoch-Schoenlein purpura: IgA mediated vasculitis or Rheumatic fever? ( 17047991 )
2007
19
Severe coronary artery disease in the setting of Henoch-Schoenlein purpura. ( 17023082 )
2007
20
Severe coronary artery disease in Henoch-Schoenlein purpura: superimposition of antiphospholipid or polyangitis overlap syndrome? ( 17363087 )
2007
21
IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. ( 17495451 )
2007
22
Severe gastrointestinal vasculitis in Henoch-Schoenlein purpura: pathophysiologic mechanisms, the diagnostic value of factor XIII, and therapeutic options. ( 17333275 )
2007
23
Koebner's phenomenon in Henoch Schoenlein purpura and role of pressure in its causation. ( 17498445 )
2007
24
Recurrence of Henoch-Schoenlein purpura nephritis after long-term remission in a 15-year-old girl. ( 16721585 )
2006
25
Decreased factor XIII activity during severe Henoch-Schoenlein purpura -- does it play a role? ( 16688675 )
2006
26
Streptococcal origin of a case of Henoch-Schoenlein purpura nephritis. ( 16509462 )
2006
27
Successful treatment of crescentic glomerulonephritis associated with adult-onset Henoch-Schoenlein purpura by double-filtration plasmapheresis. ( 15077873 )
2004
28
Clinical and pathological features of children with Henoch-Schoenlein purpura nephritis: risk factors associated with poor prognosis. ( 14524577 )
2003
29
Glomerulocystic kidney disease (GCKD) associated with Henoch-Schoenlein purpura: a case report and a review of adult cases of GCKD. ( 12036200 )
2002
30
Henoch-Schoenlein purpura with nephritis in two siblings following infectious mononucleosis. ( 12369497 )
2002
31
Severe glomerulonephritis and isolated ileitis in adult Henoch-Schoenlein purpura. ( 11770802 )
2001
32
Glomerulonephritis and Henoch-Schoenlein purpura associated with acute parvovirus B19 infection. ( 10749307 )
2000
33
Elevated levels of circulating immunostimulatory 90K in Henoch-Schoenlein purpura. ( 10226889 )
1999
34
High levels of IgA anticardiolipin antibodies in patients with systemic lupus erythematosus, Henoch-Schoenlein purpura, Sneddon's syndrome and recurrent pregnancy loss. ( 10613673 )
1999
35
Acute renal failure in an adult patient with Henoch-Schoenlein purpura after episode of macroscopic hematuria. ( 10048122 )
1999
36
Evolution of IgA nephropathy into Henoch-Schoenlein purpura in an adult. ( 9524783 )
1998
37
Response of crescentic Henoch-Schoenlein purpura nephritis to corticosteroid and azathioprine therapy. ( 9491279 )
1998
38
Henoch-Schoenlein purpura and acute interstitial nephritis after intravenous vancomycin administration in a patient with a staphylococcal infection. ( 9645421 )
1998
39
Atypical presentation of Henoch-Schoenlein purpura in two children. ( 9217530 )
1997
40
Bilateral ureteral obstruction associated with Henoch-Schoenlein purpura. ( 9203189 )
1997
41
Pulmonary hemorrhage: an often fatal complication of Henoch-Schoenlein purpura. ( 9263314 )
1997
42
[Henoch-Schoenlein purpura-nephritis followed by IgA-nephritis in 3 children]. ( 8720706 )
1996
43
Rapidly progressive glomerulonephritis in a patient with Henoch-Schoenlein purpura. Spontaneous recovery of renal function after six months of maintenance hemodialysis. ( 7606884 )
1995
44
Henoch-Schoenlein purpura and angiotensin-converting enzyme inhibitors. ( 8052354 )
1994
45
Henoch-Schoenlein purpura due to streptokinase. ( 8288725 )
1993
46
Henoch-Schoenlein purpura. ( 1626007 )
1992
47
Skin necrosis following venepuncture in a child with Henoch-Schoenlein purpura. ( 1959550 )
1991
48
Serum IgG subclasses and IgM imbalances in adult IgA mesangial glomerulonephritis and idiopathic Henoch-Schoenlein purpura. ( 2702774 )
1989
49
Monocyte infiltration and cross-linked fibrin deposition in IgA nephritis and Henoch-Schoenlein purpura nephritis. ( 2791360 )
1989
50
Recurrence of Henoch Schoenlein purpura nephritis associated with tuberculous pleuritis. ( 3216550 )
1988

Variations for Henoch-Schoenlein Purpura

Copy number variations for Henoch-Schoenlein Purpura from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 210503 6 30400000 36600000 Copy number C4B Henoch-schoenlein purpura

Expression for Henoch-Schoenlein Purpura

Search GEO for disease gene expression data for Henoch-Schoenlein Purpura.

Pathways for Henoch-Schoenlein Purpura

GO Terms for Henoch-Schoenlein Purpura

Cellular components related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 C3 CD40LG ICAM1 MPO RNASE3 VCAM1
2 azurophil granule lumen GO:0035578 9.13 C3 MPO RNASE3
3 external side of plasma membrane GO:0009897 8.92 CD40LG CD79A ICAM1 VCAM1

Biological processes related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.62 C3 HSP90AA1 MPO RNASE3
2 response to lipopolysaccharide GO:0032496 9.54 ICAM1 MPO VCAM1
3 B cell differentiation GO:0030183 9.43 CD40LG CD79A VCAM1
4 B cell proliferation GO:0042100 9.4 CD40LG CD79A
5 regulation of immune response GO:0050776 9.26 C3 CD40LG ICAM1 VCAM1
6 membrane to membrane docking GO:0022614 9.16 ICAM1 VCAM1
7 leukocyte cell-cell adhesion GO:0007159 8.8 CD40LG ICAM1 VCAM1

Sources for Henoch-Schoenlein Purpura

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19 FMA
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74 UMLS via Orphanet
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