MCID: HNC001
MIFTS: 56

Henoch-Schoenlein Purpura

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Henoch-Schoenlein Purpura

MalaCards integrated aliases for Henoch-Schoenlein Purpura:

Name: Henoch-Schoenlein Purpura 12 15 17 70
Henoch-Schonlein Purpura 12 20 58 54
Immunoglobulin a Vasculitis 20 58
Anaphylactoid Purpura 20 58
Purpura Rheumatica 58 70
Rheumatoid Purpura 58 70
Allergic Purpura 12 32
Iga Vasculitis 58 36
Immunoglobulin-a Vasculitis 20
Purpura, Schoenlein-Henoch 44
Purpura, Schönlein-Henoch 73
Purpura, Schonlein-Henoch 20
Henoch-Sch@nlein Purpura 12
Henoch-Schönlein Purpura 73
Henoch Schonlein Purpura 20
Henoch-Schnlein Purpura 12
Henoch-Scholein Purpura 12
Purpura, Autoimmune 12
Autoimmune Purpura 12
Vascular Purpura 20

Characteristics:

Orphanet epidemiological data:

58
immunoglobulin a vasculitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: any age;

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare renal diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases


Summaries for Henoch-Schoenlein Purpura

GARD : 20 Henoch-Schonlein purpura (HSP), also called immunoglobulin A vasculitis (IgAV), is a vascular disease that primarily affects small blood vessels. The disease is characterized by abnormal deposits of immunoglobulin A (an antibody ) in the blood vessels, leading to their inflammation (vasculitis). The small vessels of the skin, joints, kidneys, and digestive organs are particularly involved. Signs and symptoms usually begin suddenly (and progress over days) and may include purple-colored spots on the skin (purpura); joint pain; and gastrointestinal problems such as abdominal pain, nausea, bloody stools, and rarely, severe complications requiring surgery. People with HSP may also develop glomerulonephritis (injury to the kidneys caused by inflammation) and poor kidney function, which may result in swelling of parts of the body or face ( edema ), and blood and protein in the urine ( hematuria and proteinuria ). Most cases of HSP occur in children and go away without causing serious or long-term health problems. Less commonly, the disease affects adults and may be more severe, leading to chronic kidney disease and kidney failure. The cause of HSP is not completely understood, but research indicates that genes (especially those involved in regulating the immune system ) may play a key role in predisposing a person to HSP, as well as its severity. However, while genes may increase the risk of developing the disease (and in some cases more than one family member has HSP), the disease itself is not inherited. Environmental "triggers" such as foods, infections, or medications may also play a role in the onset of the disease. The diagnosis of HSP may be made based on symptoms, blood and urine tests, imaging studies, and/or a biopsy of the skin or kidney. Most cases go away within several weeks without treatment. When needed, treatment aims to relieve symptoms and may include medications for pain and inflammation. People with chronic kidney involvement or advanced kidney disease may require immunosuppressive medications, hemodialysis, or kidney transplantation. The long-term outlook depends on the extent of kidney involvement. Rarely, HSP is fatal due to kidney complications. In some cases, the disease recurs, sometimes more than once.

MalaCards based summary : Henoch-Schoenlein Purpura, also known as henoch-schonlein purpura, is related to purpura and brucellosis. An important gene associated with Henoch-Schoenlein Purpura is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and Selenium Micronutrient Network. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, neutrophil and heart, and related phenotypes are nausea and vomiting and hematuria

Disease Ontology : 12 A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection.

KEGG : 36 IgA vasculitis (IgAV), also known as Henoch-Schonlein purpura (HSP), is the most common systemic small vessel vasculitis in childhood with clinical characteristics of non-thrombocytopenic palpable purpura, arthritis, and involvement of internal organs such as gastrointestine (GI) and kidney. IgAV has been associated with a history of preceding infections, especially upper respiratory tract infection. In addition, other characteristics of IgAV include the deposition of IgA and C3 in small vessel walls, polymorphonuclear neutrophil infiltration around the vessel and in vessel walls, and increased serum levels of IgA and proinflammatory cytokines at the acute stage. Combined, IgAV is regarded as a specific immune-mediated entity induced by environmental factors, particularly infections. Clinically, since there are no disease-specific laboratory abnormalities, IgAV is currently diagnosed based on symptoms and signs and histopathological findings. Treatment is supportive because IgAV is usually self-limiting except for serious GI or renal involvement.

Wikipedia : 73 Henoch-Schönlein purpura (HSP), also known as IgA vasculitis, is a disease of the skin, mucous... more...

Related Diseases for Henoch-Schoenlein Purpura

Diseases related to Henoch-Schoenlein Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 770)
# Related Disease Score Top Affiliating Genes
1 purpura 31.4 MEFV CRP CD79A C3 ACE
2 brucellosis 31.0 MPO MEFV CRP
3 ulcerative colitis 30.9 PRTN3 MPO ICAM1 CRP
4 proteinuria, chronic benign 30.9 CD79A ALB ACE
5 glomerular disease 30.8 CD79A ALB ACE
6 acalculous cholecystitis 30.8 CRP ALB
7 crescentic glomerulonephritis 30.8 VCAM1 PRTN3 MPO ICAM1
8 allergic cutaneous vasculitis 30.7 PRTN3 MPO
9 amebiasis 30.7 ICAM1 CD79A ALB
10 granulomatosis with polyangiitis 30.7 PRTN3 MPO ICOSLG CRP
11 homocysteinemia 30.7 VCAM1 CRP ALB
12 takayasu arteritis 30.6 VCAM1 ICAM1 CRP
13 allergic rhinitis 30.6 VCAM1 RNASE3 MPO ICAM1
14 mononeuropathy 30.6 PRTN3 MPO CRP ALB
15 intestinal perforation 30.5 SERPINA3 CRP ALB
16 subacute bacterial endocarditis 30.5 PRTN3 MPO CRP
17 rhinitis 30.5 VCAM1 RNASE3 ICOSLG ICAM1
18 amyloidosis aa 30.5 MEFV CRP
19 peritonitis 30.5 PRTN3 MPO MEFV ICAM1 CRP ALB
20 autoimmune vasculitis 30.5 PRTN3 MPO CRP
21 epidural abscess 30.5 CRP ALB
22 churg-strauss syndrome 30.5 RNASE3 PRTN3 MPO
23 pericarditis 30.5 MEFV CRP ALB ACE
24 proctitis 30.5 RNASE3 MPO CRP
25 anca-associated vasculitis 30.5 PRTN3 MPO C3
26 endocarditis 30.4 VCAM1 CRP ALB
27 appendicitis 30.4 MPO CRP ALB
28 antiphospholipid syndrome 30.4 VCAM1 CRP CD79A C3
29 immunoglobulin alpha deficiency 30.4 ICOSLG FCAR CD79A
30 pyelonephritis 30.4 CRP ALB ACE
31 pleurisy 30.4 MPO MEFV ICAM1 CRP
32 urinary tract infection 30.4 CRP ACE
33 duodenal obstruction 30.4 CRP ALB
34 anuria 30.4 CRP ALB ACE
35 drug allergy 30.4 CRP ALB ACE
36 fabry disease 30.4 VCAM1 MPO ICAM1 CRP
37 chickenpox 30.4 ICOSLG CRP ALB
38 mononeuritis multiplex 30.3 PRTN3 MPO CRP ACE
39 lung abscess 30.3 PRTN3 CRP ALB
40 cellulitis 30.3 RNASE3 CRP ALB
41 bacterial infectious disease 30.3 SERPINA3 ICOSLG CRP CFHR2
42 dermatitis, atopic 30.3 VCAM1 SERPINA3 RNASE3 ICOSLG ICAM1
43 common cold 30.3 RNASE3 ICOSLG ICAM1 ALB
44 rheumatic fever 30.3 ICAM1 ALB ACE
45 macular retinal edema 30.3 ICAM1 ALB ACE
46 pyuria 30.3 PRTN3 CRP C3 ALB
47 goodpasture syndrome 30.2 VCAM1 PRTN3 MPO ALB
48 lymphadenitis 30.2 SERPINA3 ICOSLG ICAM1 CRP
49 spondyloarthropathy 1 30.2 PRTN3 ICOSLG FCAR CRP CFHR2
50 acute poststreptococcal glomerulonephritis 30.2 CFHR2 CD79A C3 ALB

Comorbidity relations with Henoch-Schoenlein Purpura via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Henoch-Schoenlein Purpura:



Diseases related to Henoch-Schoenlein Purpura

Symptoms & Phenotypes for Henoch-Schoenlein Purpura

Human phenotypes related to Henoch-Schoenlein Purpura:

58 31 (show all 36)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 31 hallmark (90%) Very frequent (99-80%) HP:0002017
2 hematuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000790
3 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002027
4 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
5 purpura 58 31 hallmark (90%) Very frequent (99-80%) HP:0000979
6 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
7 bruising susceptibility 58 31 hallmark (90%) Very frequent (99-80%) HP:0000978
8 vasculitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002633
9 gastrointestinal infarctions 58 31 hallmark (90%) Very frequent (99-80%) HP:0005244
10 pustule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200039
11 encephalitis 58 31 frequent (33%) Frequent (79-30%) HP:0002383
12 arthritis 58 31 frequent (33%) Frequent (79-30%) HP:0001369
13 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
14 skin ulcer 58 31 frequent (33%) Frequent (79-30%) HP:0200042
15 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
16 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
17 migraine 58 31 frequent (33%) Frequent (79-30%) HP:0002076
18 erythema 58 31 frequent (33%) Frequent (79-30%) HP:0010783
19 orchitis 58 31 frequent (33%) Frequent (79-30%) HP:0100796
20 muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001324
21 optic atrophy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000648
22 proteinuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000093
23 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
24 hemiplegia/hemiparesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004374
25 glomerulopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100820
26 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
27 macule 58 31 occasional (7.5%) Occasional (29-5%) HP:0012733
28 urticaria 58 31 occasional (7.5%) Occasional (29-5%) HP:0001025
29 episcleritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100534
30 angioedema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100665
31 restrictive ventilatory defect 31 occasional (7.5%) HP:0002091
32 seizure 31 occasional (7.5%) HP:0001250
33 seizures 58 Occasional (29-5%)
34 vascular skin abnormality 58 Frequent (79-30%)
35 edema 58 Occasional (29-5%)
36 restrictive deficit on pulmonary function testing 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Henoch-Schoenlein Purpura:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 ACE ALB C3 CD79A CRP ICAM1

Drugs & Therapeutics for Henoch-Schoenlein Purpura

Drugs for Henoch-Schoenlein Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
8
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
9
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
10
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11 Gastrointestinal Agents Phase 4
12 Hormones Phase 4
13 Antiemetics Phase 4
14 Hormone Antagonists Phase 4
15 glucocorticoids Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Neuroprotective Agents Phase 4
19 Methylprednisolone Acetate Phase 4
20 Protective Agents Phase 4
21 Calcineurin Inhibitors Phase 4
22 Cyclosporins Phase 4
23 Antifungal Agents Phase 4
24 Dermatologic Agents Phase 4
25
Colchicine Approved Phase 3 64-86-8 6167 2833
26 Antirheumatic Agents Phase 3
27 Immunoglobulin A Phase 3
28 Antimitotic Agents Phase 3
29 Tubulin Modulators Phase 3
30
Dipyridamole Approved Phase 1, Phase 2 58-32-2 3108
31
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
32
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
33
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
34
Mycophenolic acid Approved Phase 2 24280-93-1 446541
35
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
36
Benazepril Approved, Investigational Phase 2 86541-75-5 5362124
37
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
38
Azathioprine Approved Phase 2 446-86-6 2265
39
Dapsone Approved, Investigational Phase 2 80-08-0 2955
40
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
41 Tripterygium Phase 1, Phase 2
42 Antihypertensive Agents Phase 1, Phase 2
43 Vasodilator Agents Phase 1, Phase 2
44 Fibrinolytic Agents Phase 1, Phase 2
45 Skullcap Phase 1, Phase 2
46 Phosphodiesterase Inhibitors Phase 1, Phase 2
47 Platelet Aggregation Inhibitors Phase 1, Phase 2
48 Pharmaceutical Solutions Phase 1, Phase 2
49 Cardiac Glycosides Phase 1, Phase 2
50 Astragalus Phase 1, Phase 2

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Off-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and Safety Completed NCT03222687 Phase 4 tacrolimus;prednisone
2 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
3 Evaluation of Efficacy of Colchicine to Prevent Skin Relapses in Adult's IgA Vasculitis Not yet recruiting NCT04008316 Phase 3 Colchicine
4 Demonstrated Study on Children Henoch-Schönlein Purpura Nephritis With Multistep Treatment of Traditional Chinese Medicine Combined Disease and Syndrome Differentiation Unknown status NCT03591471 Phase 1, Phase 2 Glycosides Of Tripterygium Wilfordii Hook(GTW);Sulfotanshinone Sodium Injection;Chinese herbs based on syndrome differentiation;Prednisone Acetate Tablets;Benazepril Hydrochloride Tablets;Low Molecular Weight Heparin Calcium Injection;Dipyridamole Tab 25 MG;Chinese medicine placebo
5 Research on the Blood- Cooling - Toxin - Removing - Stasis - Dispersing Protocol Evaluation of Hench-schonlein Purpura Unknown status NCT01104428 Phase 2 Placebo;"ziying" granules
6 The Research of Standard Diagnosis and Treatment for Severe Henoch-Schonlein Purpura in Children Recruiting NCT02540720 Phase 2 Dexamethasone;Gamma globulin
7 The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis in Children Recruiting NCT02532777 Phase 2 Prednisone;Cyclophosphamide(CTX);Mycophenolate mofetil(MMF);Leflunomide(LEF);Angiotensin-converting enzyme inhibitor(ACEI);Methylprednisolone
8 The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis With Mild Proteinuria in Children Recruiting NCT02532790 Phase 2 Prednisone;ACEI
9 A Randomized Multicenter Study for Isolated Skin Vasculitis Recruiting NCT02939573 Phase 2 Colchicine;Dapsone;Azathioprine
10 Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura Unknown status NCT01610830
11 Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis Unknown status NCT02878018 Qi-Ji Shen-Kang formula; Zhu-Bai formula; Yu-Shen formula;angiotensin-converting enzyme (ACE) inhibitor; adrenergic receptor binder (ARB); adrenal cortical hormone; Tripterygium wilfordii polyglycosidium; immunosuppressant
12 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
13 Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis Unknown status NCT02811770
14 MMF Versus Intravenous CTX Pulses in the Treatment of Adult Severe Henoch-Schonlein Purpura Nephritis Completed NCT00301613 Mycophenolate mofetil
15 CESAR (Randomized Therapeutic Study of Steroid vs. Steroid Plus Cyclosphosphamide for Severe Viscera Henoch-Schoenlein Purpura) Completed NCT00190229 Cyclophosphamide
16 Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura Completed NCT02317133
17 Impact of Vasculitis on Employment and Income. An Online Survey of Participants in the VCRC Patient Contact Registry Completed NCT02476292
18 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
19 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
20 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
21 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
22 The Therapeutic Value and Mechanism of Recombinant Human Interleukin-2 in Children With Henoch-schönlein Purpura Recruiting NCT04387942 IL-2
23 Clinical Study on Strategy for Refractory Henoch-Schönlein Purpura Recruiting NCT03647852 Methylprednisolone;IVIG;other basic supportive treatment
24 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
25 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068
26 Recherche d'un Marqueur Pronostique de l'Atteinte rénale du Purpura Rhumatoïde de l'Enfant. Validation de la méthode de détection Des IgA1 Avec Gradient de la Glycosylation Par spectrométrie de Masse Active, not recruiting NCT04655378
27 A Single Center Randomized Controlled Clinical Study on the Treatment of Children With Purpura Nephritis With Huaiqihuang Granules Not yet recruiting NCT04623866 Early Phase 1 Huaiqinhuang;valsartan

Search NIH Clinical Center for Henoch-Schoenlein Purpura

Cochrane evidence based reviews: purpura, schoenlein-henoch

Genetic Tests for Henoch-Schoenlein Purpura

Anatomical Context for Henoch-Schoenlein Purpura

MalaCards organs/tissues related to Henoch-Schoenlein Purpura:

40
Kidney, Neutrophil, Heart, Lung, Skin, Endothelial, Bone

Publications for Henoch-Schoenlein Purpura

Articles related to Henoch-Schoenlein Purpura:

(show top 50) (show all 875)
# Title Authors PMID Year
1
Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis. 20
30454736 2019
2
IgA Vasculitis: Genetics and Clinical and Therapeutic Management. 20
29611051 2018
3
Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review. 20
29353097 2018
4
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). 20
29037908 2017
5
Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura. 61 54
20056836 2010
6
Vasculitic IgA nephropathy: prognosis and outcome. 54 61
19342865 2009
7
Pathogenesis-related adhesion molecules in Henoch-Schonlein vasculitis. 61 54
17701178 2008
8
Cardiac manifestations of Henoch-Schoenlein purpura: IgA mediated vasculitis or Rheumatic fever? 54 61
17047991 2007
9
Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis. 54 61
17347555 2007
10
[Role of mast cells and eosinophil cationic protein in the pathogenesis of Henoch-Schonlein purpura nephritis]. 61 54
16836844 2006
11
[Anti-mesangial cell autoantibodies and their target antigens in lupus nephritis]. 54 61
14728876 2003
12
Circulating soluble selectins in Kawasaki disease. 54 61
9182890 1997
13
[Diagnostic value of serum IGA-fibronectin aggregates to IGA nephropathy]. 61 54
9812564 1997
14
Recurrence of immunoglobulin A nephropathy with immunoglobulin A antineutrophil cytoplasmic antibodies following renal transplantation. 54 61
9002541 1997
15
IgA deposition in the skin of patients with alcoholic liver disease. 54 61
8720981 1996
16
von Willebrand factor and factor XIII in children with Henoch-Schonlein purpura. 61 54
8580019 1995
17
Henoch-Schoenlein purpura due to streptokinase. 54 61
8288725 1993
18
Autoimmunity to glomerular antigens in Henoch-Schoenlein nephritis. 54 61
1327645 1992
19
Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis. 54 61
1682080 1991
20
Clinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch-Schonlein Purpura: a meta-analysis. 61
33412982 2021
21
Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): a prospective, multicentre cohort study. 61
33186517 2021
22
Diagnosis and management of leukocytoclastic vasculitis. 61
33713282 2021
23
Pulmonary Manifestations of Systemic Vasculitis in Children. 61
33228930 2021
24
Mediterranean spotted fever associated with leucocytoclastic vasculitis and acute pancraeatitis. 61
33622746 2021
25
Meta-analysis of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Henoch-Schonlein purpura and its complications. 61
33588173 2021
26
MicroRNA profiling in Chinese children with Henoch-Schonlein purpura and association between selected microRNAs and inflammatory biomarkers. 61
33533510 2021
27
Purpurona: A Novel Report of COVID-19-Related Henoch-Schonlein Purpura in a Child. 61
33201063 2021
28
Scabies, incomplete lupus erythematosus and Henoch-Schonlein purpura. 61
33747295 2021
29
Effects of dexamethasone and gamma globulin combined with prednisone on the therapeutic effect and immune function of Henoch-Schonlein purpura nephritis in children. 61
33174652 2021
30
A child with Henoch-Schonlein purpura secondary to a COVID-19 infection. 61
33408113 2021
31
EPSTEIN-BARR VIRUS-ASSOCIATED HAEMORRHAGIC BULLOUS HENOCH-SCHONLEIN PURPURA. 61
33351245 2020
32
Obesity is associated with severe clinical course in children with Henoch-Schonlein purpura. 61
32613276 2020
33
Value of electron microscopy in the pathological diagnosis of native kidney biopsies in children. 61
32620982 2020
34
Immunoglobulin A Nephropathy, Celiac Disease, and Immune Complex Pneumonitis: A Rare Case Report of an Immunoglobulin A-Associated Pathologic Trifecta. 61
33482964 2020
35
Acne fulminans concomitant with vasculitis-like symptoms mimicking Henoch-Schoenlein purpura. 61
33006150 2020
36
Factor XIII as a potential predictor of severe gastrointestinal involvement in Henoch Schoenlein purpura: A case study research. 61
32297405 2020
37
Complementary Use of U.S. FDA's Adverse Event Reporting System and Sentinel System to Characterize Direct Oral Anticoagulants-Associated Cutaneous Small Vessel Vasculitis. 61
33090530 2020
38
An Unusual Clinical Presentation of Immunoglobulin A Vasculitis in an Elderly Patient. 61
33200059 2020
39
Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients. 61
33036556 2020
40
Posterior reversible encephalopathy syndrome associated with Henoch Schonlein Purpura in a pediatric patient. 61
33097321 2020
41
A Modified Regimen of Methylprednisolone, Cyclophosphamide, and Mycophenolic Acid for Severe IgA Vasculitis with Nephritis in a Child. 61
33229778 2020
42
Effect observation of individualized graded nursing on blood coagulation function in children with henoch schonlein purpura nephritis. 61
32942831 2020
43
Positive effect of individualized grading nursing on blood coagulation function in children with henoch schonlein purpura nephritis. 61
32880421 2020
44
[Clinical efficacy and safety of acupuncture combined with western medicine in treatment of children with abdominal Henoch-Schonlein purpura with spleen-stomach damp-heat syndrome]. 61
32869580 2020
45
Serosal surface small vessel vasculitis in Henoch-Schonlein purpura. 61
32037185 2020
46
Hypertension in the absence of urinary abnormalities - An unusual presentation of anaphylactoid purpura. 61
32724011 2020
47
Active Surveillance of Adverse Events Following Human Papillomavirus Vaccination: Feasibility Pilot Study Based on the Regional Health Care Information Platform in the City of Ningbo, China. 61
32234696 2020
48
Clostridioides difficile infection in a patient with immunoglobulin A vasculitis: a triggering factor or a rare complication of the disease? A case-based review. 61
32318801 2020
49
Low Back Pain and Swelling as an Atypical Presentation of IgA Vasculitis. 61
32426683 2020
50
Crescentic glomerulonephritis in children. 61
32052153 2020

Variations for Henoch-Schoenlein Purpura

Copy number variations for Henoch-Schoenlein Purpura from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 210503 6 30400000 36600000 Copy number C4B Henoch-schoenlein purpura

Expression for Henoch-Schoenlein Purpura

Search GEO for disease gene expression data for Henoch-Schoenlein Purpura.

Pathways for Henoch-Schoenlein Purpura

Pathways related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 VCAM1 SERPINA3 RNASE3 PRTN3 MPO MEFV
2
Show member pathways
11.69 SERPINA3 MPO ICAM1 CRP ALB
3 11.25 VCAM1 ICOSLG ICAM1
4 10 VCAM1 MPO ICAM1

GO Terms for Henoch-Schoenlein Purpura

Cellular components related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 SERPINA3 RNASE3 PRTN3 MPO LGALS3BP FCAR
2 extracellular exosome GO:0070062 9.93 VCAM1 SERPINA3 PRTN3 MPO MEST LGALS3BP
3 external side of plasma membrane GO:0009897 9.77 VCAM1 ICOSLG ICAM1 CD79A ACE
4 blood microparticle GO:0072562 9.62 SERPINA3 LGALS3BP C3 ALB
5 extracellular space GO:0005615 9.4 VCAM1 SERPINA3 RNASE3 PRTN3 MPO MIR98
6 azurophil granule lumen GO:0035578 9.35 SERPINA3 RNASE3 PRTN3 MPO C3

Biological processes related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.5 MPO LTC4S ALB
2 neutrophil mediated immunity GO:0002446 9.26 FCAR ACE
3 membrane to membrane docking GO:0022614 9.16 VCAM1 ICAM1
4 cellular response to amyloid-beta GO:1904646 9.13 VCAM1 MIR98 ICAM1
5 neutrophil degranulation GO:0043312 9.1 SERPINA3 RNASE3 PRTN3 MPO FCAR C3

Sources for Henoch-Schoenlein Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
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54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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