MCID: HNC001
MIFTS: 54

Henoch-Schoenlein Purpura

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Henoch-Schoenlein Purpura

MalaCards integrated aliases for Henoch-Schoenlein Purpura:

Name: Henoch-Schoenlein Purpura 12 15 17 71
Henoch-Schonlein Purpura 12 52 58 54
Immunoglobulin a Vasculitis 52 58
Anaphylactoid Purpura 52 58
Allergic Purpura 12 32
Iga Vasculitis 58 36
Immunoglobulin-a Vasculitis 52
Purpura, Schoenlein-Henoch 43
Purpura, Schönlein-Henoch 74
Purpura, Schonlein-Henoch 52
Henoch-Sch@nlein Purpura 12
Henoch-Schönlein Purpura 74
Henoch Schonlein Purpura 52
Henoch-Schnlein Purpura 12
Henoch-Scholein Purpura 12
Purpura, Autoimmune 12
Autoimmune Purpura 12
Purpura Rheumatica 58
Rheumatoid Purpura 58
Vascular Purpura 52

Characteristics:

Orphanet epidemiological data:

58
immunoglobulin a vasculitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: any age;

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare renal diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases


Summaries for Henoch-Schoenlein Purpura

NIH Rare Diseases : 52 Henoch-Schonlein purpura (HSP), also called immunoglobulin A vasculitis (IgAV), is a vascular disease that primarily affects small blood vessels. The disease is characterized by abnormal deposits of immunoglobulin A (an antibody ) in the blood vessels, leading to their inflammation (vasculitis). The small vessels of the skin, joints, kidneys, and digestive organs are particularly involved. Signs and symptoms usually begin suddenly (and progress over days) and may include purple-colored spots on the skin (purpura); joint pain; and gastrointestinal problems such as abdominal pain, nausea, bloody stools, and rarely, severe complications requiring surgery. People with HSP may also develop glomerulonephritis (injury to the kidneys caused by inflammation) and poor kidney function, which may result in swelling of parts of the body or face (edema ), and blood and protein in the urine (hematuria and proteinuria ). Most cases of HSP occur in children and go away without causing serious or long-term health problems. Less commonly, the disease affects adults and may be more severe, leading to chronic kidney disease and kidney failure. The cause of HSP is not completely understood, but research indicates that genes (especially those involved in regulating the immune system ) may play a key role in predisposing a person to HSP, as well as its severity. However, while genes may increase the risk of developing the disease (and in some cases more than one family member has HSP), the disease itself is not inherited . Environmental "triggers" such as foods, infections, or medications may also play a role in the onset of the disease. The diagnosis of HSP may be made based on symptoms, blood and urine tests, imaging studies, and/or a biopsy of the skin or kidney. Most cases go away within several weeks without treatment. When needed, treatment aims to relieve symptoms and may include medications for pain and inflammation. People with chronic kidney involvement or advanced kidney disease may require immunosuppressive medications, hemodialysis , or kidney transplantation . The long-term outlook depends on the extent of kidney involvement. Rarely, HSP is fatal due to kidney complications. In some cases, the disease recurs, sometimes more than once.

MalaCards based summary : Henoch-Schoenlein Purpura, also known as henoch-schonlein purpura, is related to purpura and iga glomerulonephritis. An important gene associated with Henoch-Schoenlein Purpura is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and Folate Metabolism. The drugs Prednisone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and neutrophil, and related phenotypes are nausea and vomiting and arthralgia

Disease Ontology : 12 A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection.

KEGG : 36 IgA vasculitis (IgAV), also known as Henoch-Schonlein purpura (HSP), is the most common systemic small vessel vasculitis in childhood with clinical characteristics of non-thrombocytopenic palpable purpura, arthritis, and involvement of internal organs such as gastrointestine (GI) and kidney. IgAV has been associated with a history of preceding infections, especially upper respiratory tract infection. In addition, other characteristics of IgAV include the deposition of IgA and C3 in small vessel walls, polymorphonuclear neutrophil infiltration around the vessel and in vessel walls, and increased serum levels of IgA and proinflammatory cytokines at the acute stage. Combined, IgAV is regarded as a specific immune-mediated entity induced by environmental factors, particularly infections. Clinically, since there are no disease-specific laboratory abnormalities, IgAV is currently diagnosed based on symptoms and signs and histopathological findings. Treatment is supportive because IgAV is usually self-limiting except for serious GI or renal involvement.

Wikipedia : 74 Henoch-Schonlein purpura (HSP), also known as IgA vasculitis, is a disease of the skin, mucous... more...

Related Diseases for Henoch-Schoenlein Purpura

Diseases related to Henoch-Schoenlein Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 669)
# Related Disease Score Top Affiliating Genes
1 purpura 31.7 MEFV CRP CD79A CD40LG
2 iga glomerulonephritis 31.4 CFHR2 CD79A CD40LG
3 cryofibrinogenemia 31.1 CD79A CD40LG
4 c1q nephropathy 30.9 CD79A CD40LG
5 membranoproliferative glomerulonephritis 30.9 ICAM1 CFHR2 CD79A
6 amebiasis 30.8 ICAM1 CD79A CD40LG
7 acalculous cholecystitis 30.8 CRP CD40LG
8 anca-associated vasculitis 30.8 PRTN3 MPO
9 pericarditis 30.8 MEFV CRP CD40LG
10 crescentic glomerulonephritis 30.7 VCAM1 PRTN3 MPO ICAM1
11 acute poststreptococcal glomerulonephritis 30.7 CFHR2 CD79A CD40LG
12 periodontitis 30.6 MPO ICAM1 CRP
13 amyloidosis aa 30.6 MEFV CRP
14 glomerulonephritis 30.6 VCAM1 PRTN3 MPO ICAM1 CD79A CD40LG
15 allergic rhinitis 30.6 VCAM1 RNASE3 MPO ICAM1
16 brucellosis 30.5 MEFV CRP CD40LG
17 ulcerative colitis 30.5 PRTN3 MPO ICAM1 CRP
18 exanthem 30.5 PRTN3 MEFV CRP CD40LG
19 antiphospholipid syndrome 30.5 VCAM1 CRP CD40LG
20 ileus 30.5 ICAM1 CRP CD79A
21 pneumonia 30.5 MPO ICAM1 CRP CD40LG
22 cervical adenitis 30.4 MEFV CRP CD40LG
23 angioedema 30.4 LTC4S CRP CD40LG
24 pharyngitis 30.4 MEFV CRP CD40LG
25 erysipelas 30.3 MEFV CRP CD40LG
26 peritonitis 30.3 PRTN3 MPO MEFV ICAM1 CRP
27 proctitis 30.3 RNASE3 MPO CRP
28 spondyloarthropathy 1 30.3 PRTN3 CRP CD40LG
29 cat-scratch disease 30.3 CRP CD40LG
30 immune-complex glomerulonephritis 30.3 VCAM1 MPO ICAM1 CFHR2 CD40LG
31 pyuria 30.3 PRTN3 CRP CD40LG
32 chlamydia 30.3 CRP CD79A CD40LG
33 coronary artery anomaly 30.3 VCAM1 ICAM1 CRP CD40LG
34 granulomatosis with polyangiitis 30.3 PRTN3 MPO CRP CD40LG
35 toxocariasis 30.2 RNASE3 CRP CD40LG
36 takayasu arteritis 30.2 VCAM1 ICAM1 CRP CD40LG
37 pleurisy 30.2 MPO MEFV ICAM1 CRP
38 mononeuropathy 30.2 PRTN3 MPO CRP CD40LG
39 lipoid nephrosis 30.2 SERPINA3 CD79A CD40LG
40 central retinal artery occlusion 30.2 PRTN3 CRP CD40LG
41 mononeuritis multiplex 30.2 PRTN3 MPO CRP CD40LG
42 cellulitis 30.1 RNASE3 CRP CD40LG
43 urticaria 30.1 RNASE3 LTC4S CRP CD40LG
44 goodpasture syndrome 30.1 VCAM1 PRTN3 MPO CD40LG
45 vascular disease 30.1 VCAM1 MPO ICAM1 CRP CD40LG
46 lung abscess 30.1 PRTN3 CRP CD40LG
47 churg-strauss syndrome 30.1 RNASE3 PRTN3 MPO CD40LG
48 bronchitis 30.0 RNASE3 MPO CRP CD40LG
49 alpha-1-antitrypsin deficiency 30.0 SERPINA3 PRTN3 MPO
50 lymphadenitis 30.0 SERPINA3 ICAM1 CRP

Graphical network of the top 20 diseases related to Henoch-Schoenlein Purpura:



Diseases related to Henoch-Schoenlein Purpura

Symptoms & Phenotypes for Henoch-Schoenlein Purpura

Human phenotypes related to Henoch-Schoenlein Purpura:

58 31 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 31 hallmark (90%) Very frequent (99-80%) HP:0002017
2 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
3 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002027
4 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
5 hematuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000790
6 purpura 58 31 hallmark (90%) Very frequent (99-80%) HP:0000979
7 bruising susceptibility 58 31 hallmark (90%) Very frequent (99-80%) HP:0000978
8 vasculitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002633
9 gastrointestinal infarctions 58 31 hallmark (90%) Very frequent (99-80%) HP:0005244
10 pustule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200039
11 encephalitis 58 31 frequent (33%) Frequent (79-30%) HP:0002383
12 arthritis 58 31 frequent (33%) Frequent (79-30%) HP:0001369
13 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
14 erythema 58 31 frequent (33%) Frequent (79-30%) HP:0010783
15 skin ulcer 58 31 frequent (33%) Frequent (79-30%) HP:0200042
16 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
17 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
18 migraine 58 31 frequent (33%) Frequent (79-30%) HP:0002076
19 orchitis 58 31 frequent (33%) Frequent (79-30%) HP:0100796
20 seizures 58 31 occasional (7.5%) Occasional (29-5%) HP:0001250
21 muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001324
22 optic atrophy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000648
23 proteinuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000093
24 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
25 macule 58 31 occasional (7.5%) Occasional (29-5%) HP:0012733
26 hemiplegia/hemiparesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004374
27 urticaria 58 31 occasional (7.5%) Occasional (29-5%) HP:0001025
28 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
29 glomerulopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100820
30 restrictive deficit on pulmonary function testing 58 31 occasional (7.5%) Occasional (29-5%) HP:0002111
31 episcleritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100534
32 angioedema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100665
33 vascular skin abnormality 58 Frequent (79-30%)
34 edema 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Henoch-Schoenlein Purpura:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 CD40LG CD79A CRP CYP21A2 HSP90AA1 ICAM1

Drugs & Therapeutics for Henoch-Schoenlein Purpura

Drugs for Henoch-Schoenlein Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
8
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
9
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
10 Hormone Antagonists Phase 4
11 Anti-Inflammatory Agents Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 glucocorticoids Phase 4
14 Hormones Phase 4
15 Antiemetics Phase 4
16 Methylprednisolone Acetate Phase 4
17 Gastrointestinal Agents Phase 4
18 Anti-Infective Agents Phase 4
19 Autonomic Agents Phase 4
20 Protective Agents Phase 4
21 Neuroprotective Agents Phase 4
22 Immunosuppressive Agents Phase 4
23 Calcineurin Inhibitors Phase 4
24 Dermatologic Agents Phase 4
25 Cyclosporins Phase 4
26 Antifungal Agents Phase 4
27 Omega 3 Fatty Acid Phase 4
28
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
29
Ibuprofen Approved Phase 3 15687-27-1 3672
30
leucovorin Approved Phase 3 58-05-9 6006 143
31
Colchicine Approved Phase 3 64-86-8 6167 2833
32
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
33 Folic Acid Antagonists Phase 3
34 Anti-Inflammatory Agents, Non-Steroidal Phase 3
35 Vitamin B Complex Phase 3
36 Analgesics, Non-Narcotic Phase 3
37 Cyclooxygenase Inhibitors Phase 3
38 Vitamin B9 Phase 3
39 Folate Phase 3
40 Complement System Proteins Phase 3
41 Complement C5a Phase 3
42 Antimetabolites Phase 3
43 Analgesics Phase 3
44 Antimitotic Agents Phase 3
45 Immunoglobulin A Phase 3
46
Benazepril Approved, Investigational Phase 2 86541-75-5 5362124
47
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
48
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
49
Mycophenolic acid Approved Phase 2 24280-93-1 446541
50
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Off-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and Safety Completed NCT03222687 Phase 4 tacrolimus;prednisone
2 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
3 Protocol for a Randomized, Placebo-Controlled, Double-Blinded Trial to Study the Effects of Supplementary Omega-3 Fatty Acids on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
4 The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children Attending Assiut University Hospital. Recruiting NCT03692416 Phase 3 Ibuprofen;Prednisone;Methotrexate
5 Evaluation of Efficacy of Colchicine to Prevent Skin Relapses in Adult's IgA Vasculitis Not yet recruiting NCT04008316 Phase 3 Colchicine
6 Research on the Blood- Cooling - Toxin - Removing - Stasis - Dispersing Protocol Evaluation of Hench-schonlein Purpura Unknown status NCT01104428 Phase 2 Placebo;"ziying" granules
7 The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis With Mild Proteinuria in Children Recruiting NCT02532790 Phase 2 Prednisone;ACEI
8 The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis in Children Recruiting NCT02532777 Phase 2 Prednisone;Cyclophosphamide(CTX);Mycophenolate mofetil(MMF);Leflunomide(LEF);Angiotensin-converting enzyme inhibitor(ACEI);Methylprednisolone
9 The Research of Standard Diagnosis and Treatment for Severe Henoch-Schonlein Purpura in Children Recruiting NCT02540720 Phase 2 Dexamethasone;Gamma globulin
10 Demonstrated Study on Children Henoch-Schönlein Purpura Nephritis With Multistep Treatment of Traditional Chinese Medicine Combined Disease and Syndrome Differentiation Recruiting NCT03591471 Phase 1, Phase 2 Glycosides Of Tripterygium Wilfordii Hook(GTW);Sulfotanshinone Sodium Injection;Chinese herbs based on syndrome differentiation;Prednisone Acetate Tablets;Benazepril Hydrochloride Tablets;Low Molecular Weight Heparin Calcium Injection;Dipyridamole Tab 25 MG;Chinese medicine placebo
11 A Randomized Multicenter Study for Isolated Skin Vasculitis Recruiting NCT02939573 Phase 2 Colchicine;Dapsone;Azathioprine
12 An Open, One-arm, Prospective Study of a Single Dose Anti-CD20 Monoclonal Antibody Combined With Bortezomib for Treatment of Relapsed Refractory Autoimmune Hemolytic Anemia Recruiting NCT04083014 Phase 2 combination of a single dose anti-CD20 antibody and bortezomib
13 High-Dose Cyclophosphamide With CD34+ Selected Autologous Hematopoietic Cell Support for Treatment of Refractory Chronic Autoimmune Thrombocytopenia Completed NCT00001630 Phase 1
14 Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura Unknown status NCT01610830
15 Retrospective Analysis of Frequency of Systemic Involvement in IgA-positive Cutaneous Immune Complex Vasculitis Versus IgA-negative Cutaneous Immune Complex Vasculitis Unknown status NCT01815190
16 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
17 Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis Unknown status NCT02811770
18 Tonsillectomy and Primitive IgA Nephropathy in Children: Strasbourg Cohort and Assessment Practices in Inter North East Region Unknown status NCT02829164
19 Measurement of Antibodies in Adults With a History of Kawasaki Disease Unknown status NCT02853266
20 CESAR (Randomized Therapeutic Study of Steroid vs. Steroid Plus Cyclosphosphamide for Severe Viscera Henoch-Schoenlein Purpura) Completed NCT00190229 Cyclophosphamide
21 MMF Versus Intravenous CTX Pulses in the Treatment of Adult Severe Henoch-Schonlein Purpura Nephritis Completed NCT00301613 Mycophenolate mofetil
22 Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura Completed NCT02317133
23 A Phase IV Study to Assess the Safety of Menveo Vaccine Being Used by HMO Subjects Aged 11-21 Years of Age Completed NCT01452464
24 The Serum Eosinophil Cationic Protein Levels in Behçet's Disease and Its Relation to the Clinical Activity Completed NCT01584778
25 Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies. Completed NCT01715623
26 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
27 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
28 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
29 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
30 Impact of Vasculitis on Employment and Income. An Online Survey of Participants in the VCRC Patient Contact Registry Completed NCT02476292
31 National Prospective Cohort for Monitoring Children With Severe Autoimmune Cytopenia Completed NCT04070612
32 Associations of Hematologic Malignancies and Thyroid Cancer With HCV Infection Among US Military Veterans Completed NCT00342641
33 Prevalence and Early Markers of Atherosclerosis in Adults With a History of Kawasaki Disease Completed NCT01440075
34 Clinical Study on Strategy for Refractory Henoch-Schönlein Purpura Recruiting NCT03647852 Methylprednisolone;IVIG;other basic supportive treatment
35 Clinical Characteristics of Allergy, Autoimmune and Rheumatic Diseases: A Ten Year Retrospective Study Recruiting NCT01611636
36 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068
37 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
38 Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis Active, not recruiting NCT02878018 Qi-Ji Shen-Kang formula; Zhu-Bai formula; Yu-Shen formula;angiotensin-converting enzyme (ACE) inhibitor; adrenergic receptor binder (ARB); adrenal cortical hormone; Tripterygium wilfordii polyglycosidium; immunosuppressant

Search NIH Clinical Center for Henoch-Schoenlein Purpura

Cochrane evidence based reviews: purpura, schoenlein-henoch

Genetic Tests for Henoch-Schoenlein Purpura

Anatomical Context for Henoch-Schoenlein Purpura

MalaCards organs/tissues related to Henoch-Schoenlein Purpura:

40
Kidney, Skin, Neutrophil, Testes, Lung, T Cells, B Cells

Publications for Henoch-Schoenlein Purpura

Articles related to Henoch-Schoenlein Purpura:

(show top 50) (show all 842)
# Title Authors PMID Year
1
Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis. 52
30454736 2019
2
IgA Vasculitis: Genetics and Clinical and Therapeutic Management. 52
29611051 2018
3
Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review. 52
29353097 2018
4
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). 52
29037908 2017
5
Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura. 54 61
20056836 2010
6
Vasculitic IgA nephropathy: prognosis and outcome. 54 61
19342865 2009
7
Pathogenesis-related adhesion molecules in Henoch-Schonlein vasculitis. 54 61
17701178 2008
8
Cardiac manifestations of Henoch-Schoenlein purpura: IgA mediated vasculitis or Rheumatic fever? 54 61
17047991 2007
9
Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis. 54 61
17347555 2007
10
[Role of mast cells and eosinophil cationic protein in the pathogenesis of Henoch-Schonlein purpura nephritis]. 54 61
16836844 2006
11
[Anti-mesangial cell autoantibodies and their target antigens in lupus nephritis]. 54 61
14728876 2003
12
Circulating soluble selectins in Kawasaki disease. 54 61
9182890 1997
13
[Diagnostic value of serum IGA-fibronectin aggregates to IGA nephropathy]. 54 61
9812564 1997
14
Recurrence of immunoglobulin A nephropathy with immunoglobulin A antineutrophil cytoplasmic antibodies following renal transplantation. 54 61
9002541 1997
15
IgA deposition in the skin of patients with alcoholic liver disease. 54 61
8720981 1996
16
von Willebrand factor and factor XIII in children with Henoch-Schonlein purpura. 54 61
8580019 1995
17
Henoch-Schoenlein purpura due to streptokinase. 54 61
8288725 1993
18
Autoimmunity to glomerular antigens in Henoch-Schoenlein nephritis. 54 61
1327645 1992
19
Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis. 54 61
1682080 1991
20
Treatment of Refractory Henoch-Schonlein Purpura (HSP) with Dapsone: A Systematic Review. 61
32024340 2020
21
Rituximab-induced Henoch-Schonlein purpura in a patient with mantle cell lymphoma. 61
31408711 2020
22
Henoch-Schonlein Purpura Presenting With Bilateral Solid Testicular Masses in an Adult. 61
31722189 2020
23
Henoch-Schonlein purpura in pediatrics: Ten years of experience at a moderate risk office of a general hospital. 61
31984693 2020
24
Serosal surface small vessel vasculitis in Henoch-Schonlein purpura. 61
32037185 2020
25
Association of the infectious triggers with childhood Henoch-Schonlein purpura in Anhui province, China. 61
31337540 2020
26
[Dermatomyositis combined with IgA vasculitis: A case report]. 61
31848525 2019
27
Prognostic implications of normal or minimal urinary findings on long-term renal impairment in adults with Henoch-Schonlein purpura. 61
31881295 2019
28
Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch-Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression. 61
31250447 2019
29
Unusual presentation of Henoch-Schönlein purpura. 61
31630717 2019
30
[Long-term effect of Tripterygium Glycosides Tablets combined with traditional Chinese medicine on adulthood fertility]. 61
31602922 2019
31
Not your Typical Rash: A Case of IgA Nephropathy in the Setting of HIV. 61
31612096 2019
32
Role of p300 in the pathogenesis of Henoch-Schonlein purpura nephritis and as a new target of glucocorticoid therapy in mice. 61
31365430 2019
33
Indications and efficiency of dapsone in IgA vasculitis (Henoch-Schonlein purpura): case series and a review of the literature. 61
31230197 2019
34
Seizures, renal failure and acute respiratory failure: not your typical case of Henoch-Schonlein purpura. 61
31320374 2019
35
Diagnostic Value of Urinary miR-152-5p in Patients with IgA Nephropathy with Elevated Proteinuria Levels. 61
31307184 2019
36
A retrospective analysis of children with Henoch-Schonlein purpura and re-evaluation of renal pathologies using Oxford classification. 61
30895528 2019
37
Henoch-Schonlein Purpura in Children: The Role of Corticosteroids. 61
31316664 2019
38
Reader response: Severe hyperhomocysteinemia manifesting as moyamoya vasculopathy and Henoch-Schonlein purpura. 61
31160407 2019
39
Author response: Severe hyperhomocysteinemia manifesting as moyamoya vasculopathy and Henoch-Schonlein purpura. 61
31160408 2019
40
Rheumatology Panel in Pediatric Practice. 61
31102381 2019
41
Henoch-Schonlein purpura associated with HLA-B27 positive axial spondyloarthritis in a young man. 61
31129640 2019
42
Gastrointestinal bleeding in patients with Henoch-Schoenlein purpura. 61
31116483 2019
43
RhACE2 - playing an important role in inhibiting apoptosis induced by Ang II in HUVECs. 61
31145308 2019
44
Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children with Henoch-Schonlein Purpura. 61
30600750 2019
45
Chemokine Receptor 8 Can Distinguish Antineutrophil Cytoplasmic Antibody-Associated Vasculitis From Infectious Complications. 61
30899872 2019
46
Functional Immunoregulation by Heme Oxygenase 1 in Juvenile Autoimmune Diseases. 61
31288720 2019
47
Imaging in small and medium vessel vasculitis. 61
30698353 2019
48
Koebner phenomenon in leukocytoclastic vasculitis: A case report and an updated review of the literature. 61
31205713 2019
49
Childhood IgA Vasculitis (Henoch Schonlein Purpura)-Advances and Knowledge Gaps. 61
31316952 2019
50
Successful treatment of hemorrhagic bullous Henoch-Schonlein purpura with intravenous immunoglobulins. 61
30561101 2019

Variations for Henoch-Schoenlein Purpura

Copy number variations for Henoch-Schoenlein Purpura from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 210503 6 30400000 36600000 Copy number C4B Henoch-schoenlein purpura

Expression for Henoch-Schoenlein Purpura

Search GEO for disease gene expression data for Henoch-Schoenlein Purpura.

Pathways for Henoch-Schoenlein Purpura

Pathways related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 VCAM1 SERPINA3 RNASE3 PRTN3 MPO MEFV
2
Show member pathways
11.96 SERPINA3 MPO ICAM1 CRP
3 11.55 VCAM1 ICAM1 CD40LG
4
Show member pathways
11.23 VCAM1 ICAM1 CD40LG
5 10.83 VCAM1 ICAM1 CD40LG
6 10 VCAM1 MPO ICAM1

GO Terms for Henoch-Schoenlein Purpura

Cellular components related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 SERPINA3 RNASE3 PRTN3 MPO LGALS3BP HSP90AA1
2 extracellular space GO:0005615 9.36 VCAM1 SERPINA3 RNASE3 PRTN3 MPO MIR98
3 azurophil granule lumen GO:0035578 9.26 SERPINA3 RNASE3 PRTN3 MPO

Biological processes related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.72 SERPINA3 RNASE3 PRTN3 MPO HSP90AA1
2 cytokine-mediated signaling pathway GO:0019221 9.71 VCAM1 PRTN3 ICAM1 HSP90AA1
3 B cell differentiation GO:0030183 9.54 VCAM1 CD79A CD40LG
4 response to lipopolysaccharide GO:0032496 9.46 VCAM1 MPO MIR142 ICAM1
5 membrane to membrane docking GO:0022614 9.26 VCAM1 ICAM1
6 cellular response to amyloid-beta GO:1904646 9.13 VCAM1 MIR98 ICAM1
7 leukocyte cell-cell adhesion GO:0007159 8.8 VCAM1 ICAM1 CD40LG

Sources for Henoch-Schoenlein Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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