MCID: HNC001
MIFTS: 56

Henoch-Schoenlein Purpura

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Henoch-Schoenlein Purpura

MalaCards integrated aliases for Henoch-Schoenlein Purpura:

Name: Henoch-Schoenlein Purpura 12 15 17 72
Henoch-Schonlein Purpura 12 53 59 55
Immunoglobulin a Vasculitis 53 59
Anaphylactoid Purpura 53 59
Allergic Purpura 12 33
Iga Vasculitis 59 37
Immunoglobulin-a Vasculitis 53
Purpura, Schoenlein-Henoch 44
Purpura, Schönlein-Henoch 75
Purpura, Schonlein-Henoch 53
Henoch-Sch@nlein Purpura 12
Henoch-Schönlein Purpura 75
Henoch Schonlein Purpura 53
Henoch-Schnlein Purpura 12
Henoch-Scholein Purpura 12
Purpura, Autoimmune 12
Autoimmune Purpura 12
Purpura Rheumatica 59
Rheumatoid Purpura 59
Vascular Purpura 53

Characteristics:

Orphanet epidemiological data:

59
immunoglobulin a vasculitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:11123
KEGG 37 H01584
ICD9CM 35 287.0
MeSH 44 D011695
NCIt 50 C34963
SNOMED-CT 68 21148002 31912009
ICD10 33 D69.0
ICD10 via Orphanet 34 D69.0
UMLS via Orphanet 73 C0034152 C0086922
Orphanet 59 ORPHA761
UMLS 72 C0034152

Summaries for Henoch-Schoenlein Purpura

NIH Rare Diseases : 53 Henoch-Schonlein purpura (HSP), also called immunoglobulin A vasculitis (IgAV), is a vascular disease that primarily affects small blood vessels. The disease is characterized by abnormal deposits of immunoglobulin A (an antibody) in the blood vessels, leading to their inflammation (vasculitis). The small vessels of the skin, joints, kidneys, and digestive organs are particularly involved. Signs and symptoms usually begin suddenly (and progress over days) and may include purple-colored spots on the skin (purpura); joint pain; and gastrointestinal problems such as abdominal pain, nausea, bloody stools, and rarely, severe complications requiring surgery. People with HSP may also develop glomerulonephritis (injury to the kidneys caused by inflammation) and poor kidney function, which may result in swelling of parts of the body or face (edema), and blood and protein in the urine (hematuria and proteinuria). Most cases of HSP occur in children and go away without causing serious or long-term health problems. Less commonly, the disease affects adults and may be more severe, leading to chronic kidney disease and kidney failure. The cause of HSP is not completely understood, but research indicates that genes (especially those involved in regulating the immune system) may play a key role in predisposing a person to HSP, as well as its severity. However, while genes may increase the risk of developing the disease (and in some cases more than one family member has HSP), the disease itself is not inherited. Environmental "triggers" such as foods, infections, or medications may also play a role in the onset of the disease. The diagnosis of HSP may be made based on symptoms, blood and urine tests, imaging studies, and/or a biopsy of the skin or kidney. Most cases go away within several weeks without treatment. When needed, treatment aims to relieve symptoms and may include medications for pain and inflammation. People with chronic kidney involvement or advanced kidney disease may require immunosuppressive medications, hemodialysis, or kidney transplantation. The long-term outlook depends on the extent of kidney involvement. Rarely, HSP is fatal due to kidney complications. In some cases, the disease recurs, sometimes more than once.

MalaCards based summary : Henoch-Schoenlein Purpura, also known as henoch-schonlein purpura, is related to intussusception and amebiasis. An important gene associated with Henoch-Schoenlein Purpura is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Prednisone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and neutrophil, and related phenotypes are nausea and vomiting and arthralgia

Disease Ontology : 12 A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection.

KEGG : 37
IgA vasculitis (IgAV), also known as Henoch-Schonlein purpura (HSP), is the most common systemic small vessel vasculitis in childhood with clinical characteristics of non-thrombocytopenic palpable purpura, arthritis, and involvement of internal organs such as gastrointestine (GI) and kidney. IgAV has been associated with a history of preceding infections, especially upper respiratory tract infection. In addition, other characteristics of IgAV include the deposition of IgA and C3 in small vessel walls, polymorphonuclear neutrophil infiltration around the vessel and in vessel walls, and increased serum levels of IgA and proinflammatory cytokines at the acute stage. Combined, IgAV is regarded as a specific immune-mediated entity induced by environmental factors, particularly infections. Clinically, since there are no disease-specific laboratory abnormalities, IgAV is currently diagnosed based on symptoms and signs and histopathological findings. Treatment is supportive because IgAV is usually self-limiting except for serious GI or renal involvement.

Wikipedia : 75 Henoch-Schonlein purpura (HSP), also known as IgA vasculitis, is a disease of the skin, mucous... more...

Related Diseases for Henoch-Schoenlein Purpura

Diseases related to Henoch-Schoenlein Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 561)
# Related Disease Score Top Affiliating Genes
1 intussusception 31.4 CRP CD40LG
2 amebiasis 31.2 ICAM1 CD79A
3 crescentic glomerulonephritis 31.2 VCAM1 MPO ICAM1
4 cryofibrinogenemia 31.2 CD79A CD40LG
5 mononeuritis multiplex 31.1 MPO CRP
6 iga glomerulonephritis 31.1 CD79A CD40LG C1GALT1
7 acute proliferative glomerulonephritis 31.0 MPO ICAM1
8 immune-complex glomerulonephritis 31.0 VCAM1 MPO ICAM1
9 c1q nephropathy 30.9 CD79A CD40LG
10 renal tuberculosis 30.9 CRP CD79A
11 rapidly progressive glomerulonephritis 30.8 MPO ICAM1 CRP
12 amyloidosis aa 30.8 MEFV CRP
13 immunoglobulin alpha deficiency 30.8 CD79A CD40LG
14 rhinitis 30.7 VCAM1 RNASE3 ICAM1
15 peritonitis 30.7 MPO MEFV ICAM1 CRP
16 goodpasture syndrome 30.7 VCAM1 MPO
17 arteries, anomalies of 30.7 VCAM1 ICAM1 CRP
18 arteriolosclerosis 30.6 CD79A C3
19 polyarteritis nodosa 30.6 MPO MEFV CRP
20 pneumonia 30.6 MPO CRP CD40LG
21 membranoproliferative glomerulonephritis 30.5 ICAM1 CD79A C3
22 brucellosis 30.5 MEFV CRP CD40LG
23 proliferative glomerulonephritis 30.4 MPO CD79A C3
24 pharyngitis 30.4 MEFV CRP
25 membranous nephropathy 30.4 MPO CD79A C3
26 bronchitis 30.4 RNASE3 MPO CRP
27 cerebrovascular disease 30.4 VCAM1 ICAM1 CRP
28 allergic rhinitis 30.3 VCAM1 RNASE3 MPO ICAM1
29 proctitis 30.3 RNASE3 MPO CRP
30 immunoglobulin a deficiency 1 30.3 CD79A CD40LG
31 anemia, autoimmune hemolytic 30.2 CD40LG C3
32 pleurisy 30.1 MPO MEFV ICAM1 CRP
33 myeloma, multiple 29.9 HSP90AA1 CRP CD79A
34 rheumatoid arthritis 29.9 VCAM1 ICAM1 CRP CD40LG
35 dengue disease 29.9 VCAM1 ICAM1 CD40LG
36 vasculitis 29.8 VCAM1 MPO MEFV ICAM1 CRP CD40LG
37 arteriosclerosis 29.8 VCAM1 ICAM1 CRP
38 glomerulonephritis 29.8 VCAM1 MPO ICAM1 CD79A CD40LG C3
39 pulmonary disease, chronic obstructive 29.7 RNASE3 MPO CRP
40 proteasome-associated autoinflammatory syndrome 1 29.7 VCAM1 RNASE3 MPO ICAM1 CRP
41 myocardial infarction 29.7 MPO ICAM1 CRP CD40LG
42 rheumatic disease 29.6 VCAM1 CRP CD40LG
43 lemierre's syndrome 29.4 CRP C3
44 malaria 29.2 VCAM1 ICAM1 HSP90AA1 CRP CD40LG
45 hypersensitivity vasculitis 28.4 MPO MEFV HSP90AA1 CRP CD79A C3
46 systemic lupus erythematosus 28.4 VCAM1 MPO ICAM1 CRP CD79A CD40LG
47 hypersensitivity reaction type iii disease 28.3 MPO MEFV ICAM1 HSP90AA1 CRP CD79A
48 thrombocytopenic purpura, autoimmune 12.7
49 immunodeficiency, common variable, 8, with autoimmunity 11.4
50 thrombotic thrombocytopenic purpura, acquired 11.4

Graphical network of the top 20 diseases related to Henoch-Schoenlein Purpura:



Diseases related to Henoch-Schoenlein Purpura

Symptoms & Phenotypes for Henoch-Schoenlein Purpura

Human phenotypes related to Henoch-Schoenlein Purpura:

59 32 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 59 32 hallmark (90%) Very frequent (99-80%) HP:0002017
2 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
3 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
4 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
5 hematuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0000790
6 purpura 59 32 hallmark (90%) Very frequent (99-80%) HP:0000979
7 bruising susceptibility 59 32 hallmark (90%) Very frequent (99-80%) HP:0000978
8 vasculitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002633
9 gastrointestinal infarctions 59 32 hallmark (90%) Very frequent (99-80%) HP:0005244
10 pustule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200039
11 encephalitis 59 32 frequent (33%) Frequent (79-30%) HP:0002383
12 arthritis 59 32 frequent (33%) Frequent (79-30%) HP:0001369
13 fever 59 32 frequent (33%) Frequent (79-30%) HP:0001945
14 erythema 59 32 frequent (33%) Frequent (79-30%) HP:0010783
15 skin ulcer 59 32 frequent (33%) Frequent (79-30%) HP:0200042
16 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
17 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
18 migraine 59 32 frequent (33%) Frequent (79-30%) HP:0002076
19 orchitis 59 32 frequent (33%) Frequent (79-30%) HP:0100796
20 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
21 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
22 optic atrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000648
23 renal insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000083
24 proteinuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000093
25 macule 59 32 occasional (7.5%) Occasional (29-5%) HP:0012733
26 hemiplegia/hemiparesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004374
27 urticaria 59 32 occasional (7.5%) Occasional (29-5%) HP:0001025
28 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
29 glomerulopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0100820
30 restrictive deficit on pulmonary function testing 59 32 occasional (7.5%) Occasional (29-5%) HP:0002111
31 episcleritis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100534
32 angioedema 59 32 occasional (7.5%) Occasional (29-5%) HP:0100665
33 vascular skin abnormality 59 Frequent (79-30%)
34 edema 59 Occasional (29-5%)

MGI Mouse Phenotypes related to Henoch-Schoenlein Purpura:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 C1GALT1 C3 CD40LG CRP ICAM1 LTC4S
2 cellular MP:0005384 9.86 C1GALT1 C3 CD40LG CD79A HSP90AA1 ICAM1
3 hematopoietic system MP:0005397 9.76 C1GALT1 C3 CD40LG CD79A ICAM1 MEFV
4 homeostasis/metabolism MP:0005376 9.61 C1GALT1 C3 CD40LG CD79A CRP ICAM1
5 immune system MP:0005387 9.36 C1GALT1 C3 CD40LG CD79A CRP HSP90AA1

Drugs & Therapeutics for Henoch-Schoenlein Purpura

Drugs for Henoch-Schoenlein Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
7
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Anti-Inflammatory Agents Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Hormone Antagonists Phase 4
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
15 Gastrointestinal Agents Phase 4
16 Antiemetics Phase 4
17 Neuroprotective Agents Phase 4
18 Prednisolone acetate Phase 4
19 Immunologic Factors Phase 4
20 Peripheral Nervous System Agents Phase 4
21 Methylprednisolone Acetate Phase 4
22 Anti-Infective Agents Phase 4
23 Protective Agents Phase 4
24 Immunosuppressive Agents Phase 4
25 Autonomic Agents Phase 4
26 Antirheumatic Agents Phase 4
27 Calcineurin Inhibitors Phase 4
28 Dermatologic Agents Phase 4
29 Cyclosporins Phase 4
30 Antifungal Agents Phase 4
31 Omega 3 Fatty Acid Phase 4
32
Colchicine Approved Phase 3 64-86-8 6167 2833
33
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
34
leucovorin Approved Phase 3 58-05-9 143 6006
35
Ibuprofen Approved Phase 3 15687-27-1 3672
36
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
37 Tubulin Modulators Phase 3
38 Antimitotic Agents Phase 3
39 Immunoglobulin A Phase 3
40 Analgesics Phase 3
41 Cyclooxygenase Inhibitors Phase 3
42 Analgesics, Non-Narcotic Phase 3
43 Folic Acid Antagonists Phase 3
44 Complement System Proteins Phase 3
45 Nucleic Acid Synthesis Inhibitors Phase 3
46 Anti-Inflammatory Agents, Non-Steroidal Phase 3
47 Vitamin B9 Phase 3
48 Folate Phase 3
49 Vitamin B Complex Phase 3
50 Complement C5a Phase 3

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Off-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and Safety Completed NCT03222687 Phase 4 tacrolimus;prednisone
2 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
3 Protocol for a Randomized, Placebo-Controlled, Double-Blinded Trial to Study the Effects of Supplementary Omega-3 Fatty Acids on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
4 Evaluation of Efficacy of Colchicine to Prevent Skin Relapses in Adult's IgA Vasculitis Not yet recruiting NCT04008316 Phase 3 Colchicine
5 The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children Attending Assiut University Hospital. Not yet recruiting NCT03692416 Phase 3 Ibuprofen;Prednisone;Methotrexate
6 Research on the Blood- Cooling - Toxin - Removing - Stasis - Dispersing Protocol Evaluation of Hench-schonlein Purpura Unknown status NCT01104428 Phase 2 Placebo;"ziying" granules
7 The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis With Mild Proteinuria in Children Recruiting NCT02532790 Phase 2 Prednisone;ACEI
8 The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis in Children Recruiting NCT02532777 Phase 2 Prednisone;Cyclophosphamide(CTX);Mycophenolate mofetil(MMF);Leflunomide(LEF);Angiotensin-converting enzyme inhibitor(ACEI);Methylprednisolone
9 The Research of Standard Diagnosis and Treatment for Severe Henoch-Schonlein Purpura in Children Recruiting NCT02540720 Phase 2 Dexamethasone;Gamma globulin
10 Demonstrated Study on Children Henoch-Schönlein Purpura Nephritis With Multistep Treatment of Traditional Chinese Medicine Combined Disease and Syndrome Differentiation Recruiting NCT03591471 Phase 1, Phase 2 Glycosides Of Tripterygium Wilfordii Hook(GTW);Sulfotanshinone Sodium Injection;Chinese herbs based on syndrome differentiation;Prednisone Acetate Tablets;Benazepril Hydrochloride Tablets;Low Molecular Weight Heparin Calcium Injection;Dipyridamole Tab 25 MG;Chinese medicine placebo
11 A Randomized Multicenter Study for Isolated Skin Vasculitis Recruiting NCT02939573 Phase 2 Colchicine;Dapsone;Azathioprine
12 High-Dose Cyclophosphamide With CD34+ Selected Autologous Hematopoietic Cell Support for Treatment of Refractory Chronic Autoimmune Thrombocytopenia Completed NCT00001630 Phase 1
13 Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura Unknown status NCT01610830
14 Retrospective Analysis of Frequency of Systemic Involvement in IgA-positive Cutaneous Immune Complex Vasculitis Versus IgA-negative Cutaneous Immune Complex Vasculitis Unknown status NCT01815190
15 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
16 Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis Unknown status NCT02811770
17 Tonsillectomy and Primitive IgA Nephropathy in Children: Strasbourg Cohort and Assessment Practices in Inter North East Region Unknown status NCT02829164
18 Measurement of Antibodies in Adults With a History of Kawasaki Disease Unknown status NCT02853266
19 CESAR (Randomized Therapeutic Study of Steroid vs. Steroid Plus Cyclosphosphamide for Severe Viscera Henoch-Schoenlein Purpura) Completed NCT00190229 Cyclophosphamide
20 MMF Versus Intravenous CTX Pulses in the Treatment of Adult Severe Henoch-Schonlein Purpura Nephritis Completed NCT00301613 Mycophenolate mofetil
21 Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura Completed NCT02317133
22 A Phase IV Study to Assess the Safety of Menveo Vaccine Being Used by HMO Subjects Aged 11-21 Years of Age Completed NCT01452464
23 The Serum Eosinophil Cationic Protein Levels in Behçet's Disease and Its Relation to the Clinical Activity Completed NCT01584778
24 Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies. Completed NCT01715623
25 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
26 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
27 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
28 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
29 Impact of Vasculitis on Employment and Income. An Online Survey of Participants in the VCRC Patient Contact Registry Completed NCT02476292
30 Associations of Hematologic Malignancies and Thyroid Cancer With HCV Infection Among US Military Veterans Completed NCT00342641
31 Prevalence and Early Markers of Atherosclerosis in Adults With a History of Kawasaki Disease Completed NCT01440075
32 Clinical Characteristics of Allergy, Autoimmune and Rheumatic Diseases: A Ten Year Retrospective Study Recruiting NCT01611636
33 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068
34 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
35 Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis Active, not recruiting NCT02878018 Qi-Ji Shen-Kang formula; Zhu-Bai formula; Yu-Shen formula;angiotensin-converting enzyme (ACE) inhibitor; adrenergic receptor binder (ARB); adrenal cortical hormone; Tripterygium wilfordii polyglycosidium; immunosuppressant
36 Clinical Study on Strategy for Refractory Henoch-Schönlein Purpura Not yet recruiting NCT03647852 Methylprednisolone;IVIG

Search NIH Clinical Center for Henoch-Schoenlein Purpura

Cochrane evidence based reviews: purpura, schoenlein-henoch

Genetic Tests for Henoch-Schoenlein Purpura

Anatomical Context for Henoch-Schoenlein Purpura

MalaCards organs/tissues related to Henoch-Schoenlein Purpura:

41
Kidney, Skin, Neutrophil, Testes, Endothelial, T Cells, Colon

Publications for Henoch-Schoenlein Purpura

Articles related to Henoch-Schoenlein Purpura:

(show top 50) (show all 832)
# Title Authors PMID Year
1
Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis. 6
30454736 2019
2
IgA Vasculitis: Genetics and Clinical and Therapeutic Management. 6
29611051 2018
3
Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review. 6
29353097 2018
4
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). 6
29037908 2017
5
Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura. 9 38
20056836 2010
6
Vasculitic IgA nephropathy: prognosis and outcome. 9 38
19342865 2009
7
Pathogenesis-related adhesion molecules in Henoch-Schonlein vasculitis. 9 38
17701178 2008
8
Cardiac manifestations of Henoch-Schoenlein purpura: IgA mediated vasculitis or Rheumatic fever? 9 38
17047991 2007
9
Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis. 9 38
17347555 2007
10
[Role of mast cells and eosinophil cationic protein in the pathogenesis of Henoch-Schonlein purpura nephritis]. 9 38
16836844 2006
11
[Anti-mesangial cell autoantibodies and their target antigens in lupus nephritis]. 9 38
14728876 2003
12
Circulating soluble selectins in Kawasaki disease. 9 38
9182890 1997
13
[Diagnostic value of serum IGA-fibronectin aggregates to IGA nephropathy]. 9 38
9812564 1997
14
Recurrence of immunoglobulin A nephropathy with immunoglobulin A antineutrophil cytoplasmic antibodies following renal transplantation. 9 38
9002541 1997
15
IgA deposition in the skin of patients with alcoholic liver disease. 9 38
8720981 1996
16
von Willebrand factor and factor XIII in children with Henoch-Schonlein purpura. 9 38
8580019 1995
17
Henoch-Schoenlein purpura due to streptokinase. 9 38
8288725 1993
18
Autoimmunity to glomerular antigens in Henoch-Schoenlein nephritis. 9 38
1327645 1992
19
Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis. 9 38
1682080 1991
20
Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch-Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression. 38
31250447 2019
21
Role of p300 in the pathogenesis of Henoch-Schonlein purpura nephritis and as a new target of glucocorticoid therapy in mice. 38
31365430 2019
22
Indications and efficiency of dapsone in IgA vasculitis (Henoch-Schonlein purpura): case series and a review of the literature. 38
31230197 2019
23
Rituximab-induced Henoch-Schonlein purpura in a patient with mantle cell lymphoma. 38
31408711 2019
24
Seizures, renal failure and acute respiratory failure: not your typical case of Henoch-Schonlein purpura. 38
31320374 2019
25
Association of the infectious triggers with childhood Henoch-Schonlein purpura in Anhui province, China. 38
31337540 2019
26
Diagnostic Value of Urinary miR-152-5p in Patients with IgA Nephropathy with Elevated Proteinuria Levels. 38
31307184 2019
27
A retrospective analysis of children with Henoch-Schonlein purpura and re-evaluation of renal pathologies using Oxford classification. 38
30895528 2019
28
Editors' note: Severe hyperhomocysteinemia manifesting as moyamoya vasculopathy and Henoch-Schonlein purpura. 38
31160406 2019
29
Reader response: Severe hyperhomocysteinemia manifesting as moyamoya vasculopathy and Henoch-Schonlein purpura. 38
31160407 2019
30
Author response: Severe hyperhomocysteinemia manifesting as moyamoya vasculopathy and Henoch-Schonlein purpura. 38
31160408 2019
31
Henoch-Schonlein Purpura in Children: The Role of Corticosteroids. 38
31316664 2019
32
Rheumatology Panel in Pediatric Practice. 38
31102381 2019
33
Gastrointestinal bleeding in patients with Henoch-Schoenlein purpura. 38
31116483 2019
34
Henoch-Schonlein purpura associated with HLA-B27 positive axial spondyloarthritis in a young man. 38
31129640 2019
35
RhACE2 - playing an important role in inhibiting apoptosis induced by Ang II in HUVECs. 38
31145308 2019
36
Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children with Henoch-Schonlein Purpura. 38
30600750 2019
37
Chemokine Receptor 8 Can Distinguish Antineutrophil Cytoplasmic Antibody-Associated Vasculitis From Infectious Complications. 38
30899872 2019
38
Koebner phenomenon in leukocytoclastic vasculitis: A case report and an updated review of the literature. 38
31205713 2019
39
Childhood IgA Vasculitis (Henoch Schonlein Purpura)-Advances and Knowledge Gaps. 38
31316952 2019
40
Imaging in small and medium vessel vasculitis. 38
30698353 2019
41
Successful treatment of hemorrhagic bullous Henoch-Schonlein purpura with intravenous immunoglobulins. 38
30561101 2019
42
The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch-Schonlein purpura: A PRISMA-compliant meta-analysis. 38
30653104 2019
43
Efficacy and Safety of Chinese Herbs for the Prevention of the Risk of Renal Damage in Henoch-Schonlein Purpura in Children: Meta-Analysis of Randomized Controlled Trials and GRADE Evaluation. 38
31118958 2019
44
[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura]. 38
30518009 2018
45
Henoch-Schonlein purpura in pregnancy: A case report. 38
30574183 2018
46
Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature. 38
30428889 2018
47
Cord-derived mesenchymal stem cells therapy for liver cirrhosis in children with refractory Henoch-Schonlein purpura: A case report. 38
30461638 2018
48
Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan. 38
30588973 2018
49
Adult Onset Henoch-Schonlein Purpura associated with a Metastatic Malignancy of Unknown Primary Origin. 38
30324001 2018
50
[Role of Th17 Cells, Interleukin-17 and Matrix Metalloproteinase-13 in Pathogenesis of Henoch-Schonlein Purpura]. 38
30295275 2018

Variations for Henoch-Schoenlein Purpura

Copy number variations for Henoch-Schoenlein Purpura from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 210503 6 30400000 36600000 Copy number C4B Henoch-schoenlein purpura

Expression for Henoch-Schoenlein Purpura

Search GEO for disease gene expression data for Henoch-Schoenlein Purpura.

Pathways for Henoch-Schoenlein Purpura

GO Terms for Henoch-Schoenlein Purpura

Cellular components related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 VCAM1 ICAM1 CD79A CD40LG
2 extracellular space GO:0005615 9.17 VCAM1 RNASE3 MPO ICAM1 CRP CD40LG
3 azurophil granule lumen GO:0035578 9.13 RNASE3 MPO C3

Biological processes related to Henoch-Schoenlein Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.73 RNASE3 MEFV CRP C3
2 neutrophil degranulation GO:0043312 9.71 RNASE3 MPO HSP90AA1 C3
3 inflammatory response GO:0006954 9.62 MEFV CRP CD40LG C3
4 response to lipopolysaccharide GO:0032496 9.54 VCAM1 MPO ICAM1
5 B cell proliferation GO:0042100 9.46 CD79A CD40LG
6 regulation of immune response GO:0050776 9.46 VCAM1 ICAM1 CD40LG C3
7 B cell differentiation GO:0030183 9.43 VCAM1 CD79A CD40LG
8 membrane to membrane docking GO:0022614 8.96 VCAM1 ICAM1
9 leukocyte cell-cell adhesion GO:0007159 8.8 VCAM1 ICAM1 CD40LG

Sources for Henoch-Schoenlein Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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