HAT
MCID: HPR003
MIFTS: 49

Heparin-Induced Thrombocytopenia (HAT)

Categories: Blood diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Heparin-Induced Thrombocytopenia

MalaCards integrated aliases for Heparin-Induced Thrombocytopenia:

Name: Heparin-Induced Thrombocytopenia 19 58 71 75
Hit 19 58
Heparin-Induced Thrombocytopenia Type 2 58
Heparin-Associated Thrombocytopenia 58
Hat 58

Characteristics:


Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 32 D69.5
UMLS via Orphanet 72 C0272285
Orphanet 58 ORPHA3325
UMLS 71 C0272285

Summaries for Heparin-Induced Thrombocytopenia

GARD: 19 Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin. It can lead to serious complications. This condition occurs in up to 5% of those who are exposed to heparin. Characteristic signs of HIT are a drop in platelet count of greater than 50% and/or the formation of new blood clots during heparin therapy.

MalaCards based summary: Heparin-Induced Thrombocytopenia, also known as hit, is related to thrombophilia due to thrombin defect and vitamin k deficiency bleeding. An important gene associated with Heparin-Induced Thrombocytopenia is PF4 (Platelet Factor 4), and among its related pathways/superpathways are Disease and Signal Transduction. The drugs Reviparin and Certoparin have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skin, and related phenotypes are hypercoagulability and autoimmune thrombocytopenia

Orphanet: 58 A rare drug-induced, immune-mediated prothrombotic disorder associated with thrombocytopenia and venous and/or arterial thrombosis.

Wikipedia: 75 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Related Diseases for Heparin-Induced Thrombocytopenia

Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 455)
# Related Disease Score Top Affiliating Genes
1 thrombophilia due to thrombin defect 31.6 PF4 F3 F2
2 vitamin k deficiency bleeding 31.2 F3 F2
3 antiphospholipid syndrome 31.0 PF4 F3 F2
4 compartment syndrome 30.6 F3 F2
5 thrombosis 30.6 PF4 ITGB3 ITGA2B F3 F2
6 mitral valve insufficiency 30.6 F3 F2
7 thrombophlebitis 30.6 F3 F2
8 stroke, ischemic 30.6 PF4 F3 F2
9 intermediate coronary syndrome 30.6 ITGA2B F3
10 thrombocytopenia 30.6 PF4 ITGB3 ITGA2B FCGR3A FCGR2A F3
11 covid-19 30.5 FCGR2A F3 F2
12 nonbacterial thrombotic endocarditis 30.5 F3 F2
13 thrombocytosis 30.5 PF4 F3 F2
14 splenic infarction 30.4 F3 F2
15 portal vein thrombosis 30.4 PF4 F3 F2
16 peripheral vascular disease 30.4 PF4 F3 F2
17 thrombophilia 30.4 PF4 ITGB3 F3 F2
18 polycythemia 30.3 ITGB3 F3 F2
19 severe covid-19 30.3 FCGR3A F3 F2
20 cardiac tamponade 30.3 F3 F2
21 essential thrombocythemia 30.3 PF4 ITGB3 ITGA2B
22 factor xii deficiency 30.2 F3 F2
23 thrombophilia due to activated protein c resistance 30.2 F3 F2
24 sagittal sinus thrombosis 30.2 PF4 F3 F2
25 transient cerebral ischemia 30.2 F3 F2
26 factor viii deficiency 30.2 F3 F2
27 branch retinal artery occlusion 30.1 F3 F2
28 prothrombin deficiency 30.1 F3 F2
29 endocarditis 30.1 PF4 ITGB3 FCGR2A F2
30 coronary thrombosis 30.1 ITGB3 ITGA2B F3
31 volvulus of midgut 30.1 F3 F2
32 polycythemia vera 30.1 PF4 ITGB3 F3 F2
33 mitral valve stenosis 30.1 PF4 F3 F2
34 antithrombin iii deficiency 30.1 PF4 F3 F2
35 acalculous cholecystitis 30.1 F3 F2
36 chronic venous insufficiency 30.0 F3 F2
37 heart septal defect 30.0 F3 F2
38 anuria 30.0 F3 F2
39 papilledema 30.0 F3 F2
40 aortic valve insufficiency 30.0 F3 F2
41 cellulitis 30.0 F3 F2
42 protein s deficiency 30.0 F3 F2
43 acquired thrombocytopenia 29.9 ITGB3 ITGA2B F3
44 infective endocarditis 29.9 ITGA2B F3 F2
45 mitral valve disease 29.9 F3 F2
46 acute myocardial infarction 29.9 PF4 ITGA2B F3 F2
47 atrial fibrillation 29.8 PF4 F3 F2
48 qualitative platelet defect 29.7 ITGA2B F3 F2
49 carotid artery disease 29.7 ITGA2B F3
50 thrombocytopenia due to platelet alloimmunization 29.7 PF4 ITGB3 ITGA2B FCGR2A F3

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to Heparin-Induced Thrombocytopenia

Symptoms & Phenotypes for Heparin-Induced Thrombocytopenia

Human phenotypes related to Heparin-Induced Thrombocytopenia:

58 30 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypercoagulability 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0100724
2 autoimmune thrombocytopenia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001973
3 thromboembolism 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001907
4 arterial thrombosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0004420
5 deep venous thrombosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0002625
6 increased serum serotonin 58 30 Frequent (33%) Frequent (79-30%)
HP:0003144
7 myocardial infarction 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001658
8 stroke 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001297
9 cerebral ischemia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002637
10 pulmonary embolism 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002204
11 increased inflammatory response 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012649
12 disseminated intravascular coagulation 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005521
13 mesenteric venous thrombosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0030248
14 abnormal onset of bleeding 58 30 Very rare (1%) Very rare (<4-1%)
HP:0040231
15 venous thrombosis 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 F2 F3 FCGR2A FCGR3A ITGA2B ITGB3
2 hematopoietic system MP:0005397 9.17 F2 F3 FCGR2A FCGR3A ITGA2B ITGB3

Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

Drugs for Heparin-Induced Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Reviparin Approved, Investigational Phase 4 9041-08-1
2 Certoparin Approved, Investigational Phase 4
3
Desirudin Approved Phase 4 120993-53-5 16129703
4 Heparin, Low-Molecular-Weight Phase 4
5 Liver Extracts Phase 4
6
bilirubin Phase 4 635-65-4 5280352
7
Warfarin Approved Phase 3 81-81-2, 129-06-6 54678486
8
Danaparoid Approved, Withdrawn Phase 3 308068-55-5
9
Rivaroxaban Approved Phase 3 366789-02-8 9875401
10
Apixaban Approved Phase 2 503612-47-3 10182969
11 Calcium, Dietary Phase 2
12
Calcium Nutraceutical Phase 2 7440-70-2 271
13 Immunologic Factors Phase 1
14 Fibrin fragment D
15 Fibrin Fibrinogen Degradation Products
16 Hemostatics
17 Immunoglobulins, Intravenous
18 Antibodies, Monoclonal
19 Ecarin
20 Platelet Factor 4
21 Immunoglobulins
22 Antibodies
23
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Randomized-Double Blind Trial to Assess the Incidence and Clinical Relevance of Heparin-Induced Thrombocytopenia (HIT) Antibodies in Trauma Patients Treated With Unfractionated or Low-Molecular Weight Heparin, the HIT-TRAP Trial Unknown status NCT00196417 Phase 4 Standard heparin (UFH) versus certoparin (LMWH)
2 Argatroban Versus Lepirudin in Critically Ill Patients - A Randomized Double-blind Trial Terminated NCT00798525 Phase 4 Argatroban;Lepirudin
3 A Comparative Clinical and Pharmacoeconomic Study Comparing Argatroban® IV vs Desirudin SC for Patients With Suspected Heparin-Induced Thrombocytopenia (HIT)With or Without Thrombosis Syndrome (HIT/TS) Terminated NCT00787332 Phase 4 Desirudin or Argatroban®
4 Bivalirudin PCI Registry in HIT/HITTS Patients Withdrawn NCT00759083 Phase 4 bivalirudin
5 Fondaparinux in Patients With Acute Heparin-Induced Thrombocytopenia Withdrawn NCT00603824 Phase 4 fondaparinux;argatroban or lepirudin
6 Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT) Unknown status NCT03147638 Phase 3 Warfarin, NOAC
7 Open-Label Trial to Evaluate the Efficacy and Safety of the Use of Argatroban in Patients With Heparin-Induced Thrombocytopenia Completed NCT00198588 Phase 3 argatroban
8 Anticoagulant Therapy With Bivalirudin in the Performance of PCI in Patients With Heparin-Induced Thrombocytopenia Completed NCT00043940 Phase 3 bivalirudin
9 Open-Label, Randomised, Active Controlled, Multi-Centre Ph 3 Study to Evaluate the Safety and Efficacy of Danaparoid vs Argatroban in Acute HIT Terminated NCT03809481 Phase 3 Danaparoid Sodium;Argatroban
10 Rivaroxaban for Treatment of Patients With Suspected or Confirmed Heparin-Induced Thrombocytopenia Terminated NCT01598168 Phase 3 Rivaroxaban
11 An Open-label, Multi-centre, Clinical Study to Collect Information on the Clinical Use of Argatroban in Patients With Heparin Induced Thrombocytopenia (HIT) Type II Who Require Parenteral Antithrombotic Therapy Completed NCT00861692 Phase 2 argatroban
12 A Blind-adjudication Multi-center Phase II Randomized Clinical Trial of Continuous Low-dose Intravenous Heparin Therapy in Coiled Low-grade Aneurysmal Subarachnoid Hemorrhage Patients With Significant Hemorrhage Burden Suspended NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
13 A Phase II Study to Evaluate the Efficacy and Safety of Apixaban in the Treatment of Heparin Induced Thrombocytopenia (HIT) Terminated NCT03594045 Phase 2 Apixaban
14 A Phase II Trial Using Fondaparinux in Patients With Confirmed or Suspected Heparin-Induced Thrombocytopenia (HIT) Terminated NCT00673439 Phase 2 fondaparinux;warfarin
15 A Pilot Dose-finding and Pharmacokinetic Study of Fondaparinux in Children With Deep Vein Thrombosis or Heparin-induced Thrombocytopenia Completed NCT00412464 Phase 1 Fondaparinux
16 Improving the Diagnosis of Heparin-Induced Thrombocytopenia: Utility of the 4T's Score and Evaluation of New Rapid Assays Completed NCT00489437 Phase 1
17 A Phase I, Open-Label, Randomized, Three-Period, Three-Sequence Crossover Study of the Effects of Co-administration of Intravenous VLX-1005 With Argatroban on Pharmacokinetics, Pharmacodynamics and Safety in Healthy Adult Subjects Recruiting NCT05325346 Phase 1 VLX-1005;Argatroban
18 A Multicenter, Prospective Cohort Study to Determine the Prevalence and Profile of Heparin-Induced Thrombocytopenia in Patients Undergoing Cardiovascular Surgery or Percutaneous Coronary Intervention Unknown status NCT00198575
19 Prospectively Validating the 4Ts and Chong Score for Heparin Induced Thrombocytopenia Unknown status NCT00946400
20 Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia Unknown status NCT03269019
21 Generation of HIT-antibodies Without Prior Heparin Exposure Following Orthopedic Surgery (Subgroup Study) (Change of Coagulation Parameters Under Exposition With New Anticoagulants [Title of the Main Study]) Unknown status NCT01102790
22 Study to Compare the Heparin Induced Thrombocytopenia Rates Associated With Heparin and Low Molecular Weight Heparin Usage as Well as Evaluate the Economic and Long-Term Clinical Burden of Heparin Induced Thrombocytopenia. Completed NCT00456001
23 Heparin-Induced Thrombocytopenia : Development and Validation of a Predictive Clinical Score: a Prospective Multicenter Study Under the Auspices of the French Haemostasis and Thrombosis Study Group (GEHT)in Cooperation With the French Association of Regional PharmacoVigilance Center (AFCRPV) Completed NCT00748839
24 Evaluation of Automated Immunoassay, Particle Gel Immunoassay and Pretest Scoring Systems (4Ts and HEP Scores) in the Diagnosis of Heparin-induced Thrombocytopenia in Surgical Critically Ill Patients Completed NCT02790567
25 A 3 Year Retrospective Heparin Induced Thrombocytopenia Registry (HIT) at Brigham and Women's Hospital. Completed NCT00456326
26 Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients: a Prospective Multivariate Analysis of Prognostic Factors and Haemostaseological Findings Completed NCT01654848
27 Immunogenetics of Heparin-Induced Thrombocytopenia: Aim 2 Completed NCT02526485
28 Heparin Antibodies in Intensive Care Unit Patients (HAICU) Completed NCT00283322
29 Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation Completed NCT03979625
30 Systematische Dokumentation Von Patienten Mit Akutem HIT-Verdacht Completed NCT01304238 lepirudin;danaparoid;argatroban;fondaparinux
31 Heparin-Induced Thrombocytopenia - Retrospective Analysis of Data on Incidence and Outcomes Study (HIT-RADIO Study) Completed NCT01178333
32 Effect of an Electronic Medical Record Tool on the Documentation and Management of Newly Suspected Heparin Induced Thrombocytopenia Completed NCT05439265
33 Argatroban Monitoring in Critically Ill Patients: Evaluation of a Novel Ecarin-based Bedside Test Recruiting NCT04751357
34 Pharmacogenomics of Heparin-Induced Thrombocytopenia Recruiting NCT02717039
35 Optimizing the Diagnosis of Heparin Induced Thrombocytopenia Using Quantified Anti-Platelet Factor 4 Immunological Testing: A Pilot Multicentre Cohort Study Recruiting NCT03148912
36 Multicenter Study on Dialysis Modalities for End-stage Chronic Renal Failure Patients With Heparin-induced Thrombocytopenia Not yet recruiting NCT05586854
37 Evaluation of the Intra-observer Agreement of the HEP Score in Surgical Intensive Care. Not yet recruiting NCT04782843
38 PLATELET Function Assay With Flow Imaging on ImageSTREAM Cytometer Not yet recruiting NCT04842760

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

Anatomical Context for Heparin-Induced Thrombocytopenia

Organs/tissues related to Heparin-Induced Thrombocytopenia:

MalaCards : Liver, Heart, Skin, Whole Blood, Lung, Neutrophil, Endothelial

Publications for Heparin-Induced Thrombocytopenia

Articles related to Heparin-Induced Thrombocytopenia:

(show top 50) (show all 4349)
# Title Authors PMID Year
1
A machine-learning model for reducing misdiagnosis in heparin-induced thrombocytopenia: A prospective, multicenter, observational study. 62
36457646 2023
2
Corrigendum to "A multicentre assessment of contemporary laboratory assays for heparin induced thrombocytopenia" [Pathology (53) (2021) 247-256]. 62
36414382 2022
3
Deciphering clinical abbreviations with a privacy protecting machine learning system. 62
36460656 2022
4
Regional citrate versus heparin anticoagulation for continuous renal replacement therapy in critically ill patients: A meta-analysis of randomized controlled trials. 62
35385216 2022
5
A journey through anticoagulant therapies in the treatment of left ventricular thrombus in post-COVID-19 heparin-induced thrombocytopenia: a case report. 62
35231200 2022
6
COVID-19: Vaccine-induced immune thrombotic thrombocytopenia. 62
36030503 2022
7
Laboratory Testing for Heparin-Induced Thrombocytopenia and Vaccine-Induced Immune Thrombotic Thrombocytopenia Antibodies: A Narrative Review. 62
36455619 2022
8
Vaccine-induced immune thrombotic thrombocytopenia presenting as a mimic of heparin-induced thrombocytopenia in a hemodialysis patient receiving ChAdOx1 nCoV-19 vaccine. 62
35820808 2022
9
Delayed-Type Heparin Allergy: Intravenous Tolerance Despite Inflammatory Skin Reaction After Subcutaneous Injection. 62
35788063 2022
10
Anticoagulation with nafamostat mesilate during extracorporeal life support. 62
35850387 2022
11
The use of andexanet alfa and 4-factor prothrombin complex concentrate in intracranial hemorrhage. 62
36463661 2022
12
Potential mechanisms of vaccine-induced thrombosis. 62
35953336 2022
13
Minimal role for the alternative pathway in complement activation by HIT immune complexes. 62
35996342 2022
14
Quantitative interpretation of PF4/heparin-EIA optical densities in predicting platelet-activating VITT antibodies. 62
36006172 2022
15
Variable serotonin release assay pattern and specificity of PF4-specific antibodies in HIT, and clinical relevance. 62
35971886 2022
16
Early-onset heparin-induced thrombocytopenia after cardiac surgery: Should we lose sleep? 62
36271465 2022
17
High-frequency Contactless Sensor for the Detection of Heparin-Induced Thrombocytopenia Antibodies via Platelet Aggregation. 62
36430873 2022
18
Skin changes in heparin-induced thrombocytopenia. 62
35995872 2022
19
Application of a clinical decision rule and laboratory assays in pediatrics: Adult heparin-induced thrombocytopenia. 62
35997577 2022
20
Temporal presentations of heparin-induced thrombocytopenia following cardiac surgery: A single-center, retrospective cohort study. 62
35869817 2022
21
The impact of temporary mechanical circulatory support strategies on thrombocytopenia. 62
36434833 2022
22
Bivalirudin and Venoarterial Extracorporeal Membrane Oxygenation for Treatment of Massive Pulmonary Embolism From Heparin-Induced Thrombocytopenia With Thrombosis. 62
36470755 2022
23
Evaluation of the use of direct oral anticoagulants for the management of heparin-induced thrombocytopenia. 62
36129561 2022
24
An Open-Label, Single-Arm, Pilot Intervention Study to Assess the Efficacy and Safety of Apixaban in Heparin-Induced Thrombocytopenia. 62
35656855 2022
25
Combinations of rapid immunoassays for a speedy diagnosis of heparin-induced thrombocytopenia. 62
35808841 2022
26
Delayed Onset Heparin-Induced Thrombocytopenia Presenting as Fever of Unknown Origin. 62
35671785 2022
27
Heparin Induced Thrombocytopenia in COVID-19 patients- a Diagnostic Dilemma. 62
36320593 2022
28
Double-Negative (PF4-Negative/SRA-Negative) Heparin-Induced Thrombocytopenia. 62
36252705 2022
29
Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery. 62
36447732 2022
30
Breast cancer cell-based ELISA: a potential material for better detection of heparin-induced thrombocytopenia antibodies. 62
36069407 2022
31
Evaluation of Thrombocytopenia in Patients Receiving Percutaneous Mechanical Circulatory Support With an Impella Device. 62
36248319 2022
32
High-Risk Pulmonary Embolism During Labor: JACC Patient Care Pathways. 62
36265527 2022
33
Outcomes of systemic bivalirudin and sodium bicarbonate purge solution for Impella 5.5. 62
36271639 2022
34
A Multidisciplinary Educational Approach to Anticoagulation Management for a Percutaneous Endovascular Mechanical Circulatory Support Device. 62
35094528 2022
35
Covid19 vaccination-associated portal vein thrombosis-An interdisciplinary clinical challenge. 62
35504460 2022
36
Retrospective review COVID-19 vaccine induced thrombotic thrombocytopenia and cerebral venous thrombosis-what can we learn from the immune response. 62
35926315 2022
37
Heparin-induced thrombocytopenia following Shiga-toxin-associated hemolytic uremic syndrome: a case report. 62
36273193 2022
38
Fatal intracerebral haemorrhage associated with thrombosis with thrombocytopenia syndrome after ChAdOx1-S vaccine. 62
36169326 2022
39
Anti-platelet factor 4/heparin antibodies in patients with Hantaan virus infection. 62
36246479 2022
40
Thrombocytopenia: Evaluation and Management. 62
36126009 2022
41
The potential impact of Covid-19 on the capacity of routine laboratory tests to detect heparin-induced thrombocytopenia. 62
36163073 2022
42
Thrombosis after SARS-CoV2 infection or COVID-19 vaccination: will a nonpathologic anti-PF4 antibody be a solution?-A narrative review. 62
36212029 2022
43
Ischemic Stroke Due to Heparin-induced Thrombocytopenia during Severe COVID-19 Infection. 62
35793954 2022
44
Synthesis of a Systematic 64-Membered Heparan Sulfate Tetrasaccharide Library. 62
36173931 2022
45
Comparison of Screening Scores for Heparin- Induced Thrombocytopenia After Cardiopulmonary Bypass. 62
35729026 2022
46
Association of trauma severity with antibody seroconversion in heparin-induced thrombocytopenia: A multicenter, prospective, observational study. 62
35271548 2022
47
Management of Heparin-Induced Thrombocytopenia Using Plasmapharesis in Patients Undergoing HeartMate 3 Left Ventricular Assist Device. 62
34967780 2022
48
Atrial Fibrillation in a Patient with Heparin-induced Thrombocytopenia Successfully Treated by Radiofrequency Catheter Ablation Using a Direct Thrombin Inhibitor. 62
35185059 2022
49
Hospitalized patients are needlessly over-tested for heparin induced thrombocytopenia. 62
35422372 2022
50
When Will Fondaparinux Induce Thrombocytopenia? 62
35878320 2022

Variations for Heparin-Induced Thrombocytopenia

Expression for Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for Heparin-Induced Thrombocytopenia

Pathways related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 ITGB3 ITGA2B FCGR3A FCGR2A F2
2 13.38 PF4 ITGB3 ITGA2B F3 F2
3
Show member pathways
12.83 PF4 ITGB3 ITGA2B F3 F2
4
Show member pathways
12.49 ITGB3 ITGA2B F2
5
Show member pathways
12.17 PF4 F3 F2
6
Show member pathways
12.11 ITGB3 ITGA2B FCGR3A F2
7
Show member pathways
11.87 PF4 ITGB3 F2
8
Show member pathways
11.74 FCGR2A ITGA2B ITGB3
9 11.64 ITGB3 ITGA2B FCGR2A
10
Show member pathways
11.48 ITGB3 ITGA2B F2
11 11.14 ITGB3 ITGA2B
12 11.04 ITGB3 ITGA2B F2
13 11.03 ITGB3 ITGA2B
14 10.91 FCGR3A FCGR2A
15 10.82 ITGB3 ITGA2B
16 10.79 ITGB3 ITGA2B FCGR2A
17 10.74 PF4 ITGB3 ITGA2B FCGR3A FCGR2A F3
18 10.73 ITGB3 ITGA2B

GO Terms for Heparin-Induced Thrombocytopenia

Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 9.46 ITGB3 ITGA2B
2 external side of plasma membrane GO:0009897 9.28 ITGB3 ITGA2B FCGR3A F3 F2
3 platelet alpha granule membrane GO:0031092 9.26 ITGB3 ITGA2B

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.43 ITGB3 F3 F2
2 hemostasis GO:0007599 9.16 F3 F2
3 platelet activation GO:0030168 9.1 PF4 ITGB3 F2

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.26 ITGB3 ITGA2B
2 IgG binding GO:0019864 8.92 FCGR3A FCGR2A

Sources for Heparin-Induced Thrombocytopenia

2 CDC
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8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
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29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
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43 MeSH
44 MESH via Orphanet
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49 NCIt
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52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
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72 UMLS via Orphanet
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