MCID: HPT006
MIFTS: 36

Hepatic Angiomyolipoma

Categories: Cancer diseases, Gastrointestinal diseases, Endocrine diseases

Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 50 C27485
UMLS 73 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to angiomyolipoma and lymphangioleiomyomatosis. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are ERK Signaling and PI3K-Akt signaling pathway. Affiliated tissues include liver, testes and small intestine, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 angiomyolipoma 30.1 KIT MTOR TSC2
2 lymphangioleiomyomatosis 28.8 MTOR TSC2
3 hepatocellular carcinoma 28.8 AFP MTOR MYC RB1
4 hepatitis 10.8
5 malignant biphasic mesothelioma 10.4 AFP MYC
6 mixed germ cell tumor 10.4 AFP KIT
7 intratubular embryonal carcinoma 10.3 AFP KIT
8 endometrial small cell carcinoma 10.3 AFP KIT
9 rete testis adenocarcinoma 10.3 AFP KIT
10 testicular infarct 10.3 AFP KIT
11 mediastinal cancer 10.3 AFP KIT
12 rete testis neoplasm 10.3 AFP KIT
13 germ cell and embryonal cancer 10.3 AFP MYC
14 extragonadal seminoma 10.3 AFP KIT
15 hemimegalencephaly 10.3 MTOR MYC
16 dysgerminoma of ovary 10.2 AFP KIT
17 plasmablastic lymphoma 10.2 MTOR MYC
18 fibrosarcoma of bone 10.2 KIT MYC
19 juvenile nasopharyngeal angiofibroma 10.2 KIT MYC
20 tuberous sclerosis 10.2
21 suppressor of tumorigenicity 3 10.1 MYC RB1
22 teratoma 10.0 AFP KIT
23 angiosarcoma 10.0 KIT MYC
24 retinal cancer 10.0 MYC RB1
25 sensory system cancer 10.0 MYC RB1
26 tuberous sclerosis 1 10.0
27 testicular germ cell tumor 9.9 AFP KIT
28 reproductive organ benign neoplasm 9.9 AFP TSC2
29 ocular cancer 9.9 MYC RB1
30 hemangioma 9.9
31 subependymal glioma 9.9 MTOR TSC2
32 kidney angiomyolipoma 9.9 MTOR TSC2
33 benign ependymoma 9.8 MTOR TSC2
34 nervous system cancer 9.8 MYC RB1
35 renal cell carcinoma, papillary, 1 9.8 KIT MTOR
36 cell type cancer 9.8 AFP KIT MYC
37 gastrointestinal system cancer 9.8 AFP KIT MYC
38 perivascular epithelioid cell tumor 9.8 KIT TSC2
39 subependymal giant cell astrocytoma 9.8 MTOR TSC2
40 focal cortical dysplasia, type ii 9.8 MTOR TSC2
41 neurofibromatosis, type ii 9.7
42 arteriovenous fistula 9.7
43 ulcerative colitis 9.7
44 colitis 9.7
45 disseminated intravascular coagulation 9.7
46 melanoma 9.7
47 rhabdomyosarcoma 9.7
48 cavernous hemangioma 9.7
49 pancreatitis 9.7
50 giant hemangioma 9.7

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

GenomeRNAi Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.4 MTOR
2 Decreased viability GR00221-A-1 9.4 KIT MTOR MYC
3 Decreased viability GR00221-A-3 9.4 MYC
4 Decreased viability GR00221-A-4 9.4 MTOR
5 Decreased viability GR00301-A 9.4 KIT
6 Decreased viability GR00342-S-1 9.4 MTOR
7 Decreased viability GR00342-S-2 9.4 MTOR
8 Decreased viability GR00402-S-2 9.4 KIT MTOR MYC

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 RB1 MTOR AFP MYC KIT TSC2
2 endocrine/exocrine gland MP:0005379 9.97 RB1 MTOR AFP MYC KIT TSC2
3 homeostasis/metabolism MP:0005376 9.95 RB1 MTOR AFP MYC KIT TSC2
4 cardiovascular system MP:0005385 9.92 KIT RB1 MTOR MYC TSC2
5 embryo MP:0005380 9.91 RB1 MTOR MYC KIT TSC2
6 mortality/aging MP:0010768 9.91 KIT RB1 MTOR AFP MYC TSC2
7 liver/biliary system MP:0005370 9.85 RB1 AFP MYC KIT TSC2
8 neoplasm MP:0002006 9.77 RB1 AFP MYC KIT TSC2
9 muscle MP:0005369 9.71 MYC KIT MTOR RB1
10 normal MP:0002873 9.65 RB1 MTOR MYC KIT TSC2
11 no phenotypic analysis MP:0003012 9.62 KIT RB1 MTOR MYC
12 pigmentation MP:0001186 9.33 KIT MYC RB1
13 renal/urinary system MP:0005367 9.26 KIT RB1 MTOR TSC2
14 reproductive system MP:0005389 9.02 RB1 AFP MYC KIT TSC2

Drugs & Therapeutics for Hepatic Angiomyolipoma

Search Clinical Trials , NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

41
Liver, Testes, Small Intestine

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 143)
# Title Authors Year
1
Hepatic angiomyolipoma detected using computed tomography. ( 29392859 )
2018
2
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. ( 29512829 )
2018
3
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. ( 29392818 )
2018
4
Hepatic Angiomyolipoma Staining in the Post-vascular Phase of Contrast-enhanced Ultrasound Due to the Presence of Macrophages. ( 29279500 )
2017
5
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex. ( 29237943 )
2017
6
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. ( 28122404 )
2017
7
Management of hepatic angiomyolipoma: A systematic review. ( 28177188 )
2017
8
Hepatic angiomyolipomas may overexpress TFE3, but have no relevant genetic alterations. ( 27865795 )
2017
9
A case of ruptured hepatic angiomyolipoma in a young male. ( 28449573 )
2017
10
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. ( 28809731 )
2017
11
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. ( 28327196 )
2017
12
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. ( 29241297 )
2017
13
CD68-Positive Cells in Hepatic Angiomyolipoma. ( 28030864 )
2016
14
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. ( 26867906 )
2016
15
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. ( 27248975 )
2016
16
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. ( 26617933 )
2015
17
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. ( 26114004 )
2015
18
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. ( 25805953 )
2015
19
Hepatic angiomyolipoma with special attention to radiologic imaging. ( 26366342 )
2015
20
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. ( 26943379 )
2015
21
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. ( 26147859 )
2015
22
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25803731 )
2015
23
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: A case report. ( 25834347 )
2015
24
Alterations of the mTOR Pathway in Hepatic Angiomyolipoma with Emphasis on the Epithelioid Variant and Loss of Heterogeneity of the TSC1/TSC2 Genes. ( 25234729 )
2014
25
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25526436 )
2014
26
Hepatic angiomyolipoma: what management? ( 25073214 )
2014
27
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. ( 26185889 )
2014
28
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. ( 26184024 )
2014
29
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. ( 24389893 )
2014
30
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. ( 24670055 )
2014
31
Immunohistochemical character of hepatic angiomyolipoma: for its management. ( 23864864 )
2013
32
Is surgery necessary for patients with hepatic angiomyolipoma? Retrospective analysis from eight Chinese cases. ( 23731017 )
2013
33
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. ( 24314304 )
2013
34
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. ( 22996326 )
2013
35
Fat-deficient hepatic angiomyolipoma: a radiological challenge. ( 23701714 )
2013
36
Hepatic angiomyolipoma: a case report with diagnostic challenge. ( 24152510 )
2013
37
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. ( 23679956 )
2013
38
Large hepatic angiomyolipoma. ( 23433965 )
2013
39
Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases. ( 23292871 )
2013
40
Hepatic angiomyolipoma: diagnostic findings and management. ( 23320180 )
2012
41
Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsy. ( 22949933 )
2012
42
Diagnosis and treatment of hepatic angiomyolipoma. ( 24570900 )
2012
43
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. ( 23091816 )
2012
44
Hepatic angiomyolipoma: contrast patterns with SonoVue-enhanced real-time gray-scale ultrasonography. ( 22524813 )
2012
45
Sporadic exophytic hepatic angiomyolipoma. ( 23060385 )
2012
46
Diagnosis and treatment of hepatic angiomyolipoma. ( 21283992 )
2011
47
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. ( 21683235 )
2011
48
Diagnostic difficulties and treatment strategy of hepatic angiomyolipoma. ( 22464831 )
2011
49
Angiogenesis and lymphangiogenesis in sporadic hepatic angiomyolipoma. ( 21665376 )
2011
50
Hepatic angiomyolipoma with a giant hemangioma. ( 22041879 )
2011

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 KIT MTOR MYC RB1 TSC2
2
Show member pathways
12.59 KIT MTOR MYC RB1 TSC2
3 12.56 KIT MTOR MYC RB1
4
Show member pathways
12.51 MTOR RB1 TSC2
5
Show member pathways
12.47 KIT MTOR TSC2
6
Show member pathways
12.46 KIT MTOR MYC RB1
7
Show member pathways
12.46 KIT MTOR MYC RB1 TSC2
8
Show member pathways
12.32 MTOR MYC RB1
9
Show member pathways
12.28 MTOR MYC RB1
10
Show member pathways
12.16 KIT MTOR TSC2
11
Show member pathways
12.12 MYC RB1 TSC2
12 11.9 MTOR MYC TSC2
13 11.84 AFP RB1 TSC2
14
Show member pathways
11.8 MTOR MYC TSC2
15 11.76 MTOR MYC RB1 TSC2
16 11.75 MTOR MYC TSC2
17 11.64 MTOR MYC RB1 TSC2
18 11.57 KIT MYC
19 11.54 MYC RB1
20 11.54 MYC RB1
21
Show member pathways
11.49 MTOR MYC
22 11.49 MTOR MYC RB1
23 11.48 MTOR MYC
24 11.45 KIT MTOR MYC
25 11.44 MTOR TSC2
26 11.43 MYC TSC2
27 11.33 MTOR MYC TSC2
28 11.32 MYC RB1
29 11.31 MTOR MYC
30 11.3 MTOR TSC2
31 11.3 MTOR MYC RB1 TSC2
32 11.29 MYC RB1
33 11.2 MTOR MYC TSC2
34 11.18 MYC RB1
35 11.14 MTOR TSC2
36
Show member pathways
11.11 MTOR MYC RB1 TSC2
37 11.08 MTOR TSC2
38 11.02 MTOR TSC2
39 10.9 MYC RB1

GO Terms for Hepatic Angiomyolipoma

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.61 KIT MTOR MYC
2 regulation of cell growth GO:0001558 9.49 MTOR RB1
3 positive regulation of translation GO:0045727 9.48 MTOR MYC
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 MTOR MYC
5 visual learning GO:0008542 9.4 KIT MTOR
6 digestive tract development GO:0048565 9.37 KIT RB1
7 ovarian follicle development GO:0001541 9.32 KIT MYC
8 energy reserve metabolic process GO:0006112 9.26 MTOR MYC
9 positive regulation of glial cell proliferation GO:0060252 9.16 MTOR MYC
10 anoikis GO:0043276 8.96 MTOR TSC2
11 cell cycle arrest GO:0007050 8.92 MTOR MYC RB1 TSC2

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoprotein binding GO:0051219 8.62 MTOR RB1

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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