MCID: HPT006
MIFTS: 32

Hepatic Angiomyolipoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 49 C27485
UMLS 71 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to tuberous sclerosis and angiomyolipoma. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. Affiliated tissues include liver, small intestine and colon, and related phenotypes are integument and neoplasm

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 tuberous sclerosis 30.5 TSC2 MYC MTOR MLANA
2 angiomyolipoma 29.9 TSC2 TFE3 MTOR MLANA KIT AFP
3 liver inflammatory pseudotumor 29.9 CD34 AFP
4 kidney angiomyolipoma 29.8 TSC2 TFE3 MTOR MLANA
5 cavernous hemangioma 29.8 KIT CD34 AFP
6 rhabdomyosarcoma 29.4 RB1 MYC MTOR KIT
7 lipomatosis, multiple 29.2 MLANA KIT CD34
8 neurilemmoma 29.2 MLANA KIT CD34
9 leiomyoma 29.1 TSC2 KIT CD34
10 hemangioma 29.1 TSC2 MYC MTOR KIT CD34
11 melanoma 28.9 RB1 MYC MTOR MLANA KIT
12 perivascular epithelioid cell tumor 28.9 TSC2 TFE3 MLANA KIT
13 leukemia, acute lymphoblastic 28.5 RB1 MYC KIT CD34
14 mesenchymal cell neoplasm 28.5 TFE3 MLANA KIT CD34
15 hepatocellular carcinoma 28.2 TSC2 RB1 MYC MTOR KIT CD34
16 tuberous sclerosis 1 10.4
17 adult type testicular granulosa cell tumor 10.4 MLANA AFP
18 ovarian cystic teratoma 10.3 MLANA AFP
19 plasmablastic lymphoma 10.3 MYC MTOR
20 mature teratoma of the ovary 10.3 MLANA AFP
21 melanoacanthoma 10.3 MTOR MLANA
22 acanthoma 10.3 MTOR MLANA
23 suppressor of tumorigenicity 3 10.3 RB1 MYC
24 large cell acanthoma 10.3 MTOR MLANA
25 hemimegalencephaly 10.3 MYC MTOR
26 mixed germ cell tumor 10.3 KIT AFP
27 mediastinum seminoma 10.3 KIT AFP
28 extragonadal seminoma 10.3 KIT AFP
29 pineal region teratoma 10.3 KIT AFP
30 intratubular embryonal carcinoma 10.3 KIT AFP
31 mixed germ cell cancer 10.2 KIT AFP
32 mature teratoma 10.2 KIT AFP
33 lymphangioleiomyomatosis 10.2
34 dysgerminoma of ovary 10.2 KIT AFP
35 ovarian gonadoblastoma 10.2 KIT AFP
36 cholangiocarcinoma 10.2 MTOR CEACAM3 AFP
37 endometrial small cell carcinoma 10.2 KIT AFP
38 brain germinoma 10.2 KIT AFP
39 spermatocytoma 10.2 KIT AFP
40 paget disease, extramammary 10.2 MLANA CEACAM3
41 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
42 rare soft tissue tumor 10.2
43 rare tumor 10.2
44 polymorphous low-grade adenocarcinoma 10.2 KIT CEACAM3
45 malignant anus melanoma 10.2 MLANA KIT
46 malignant dermis tumor 10.2 MLANA KIT
47 ovarian germ cell cancer 10.2 KIT AFP
48 malignant skin fibrous histiocytoma 10.2 MLANA KIT
49 vulvar melanoma 10.2 MLANA KIT
50 obstructive hydrocephalus 10.1 TSC2 AFP

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.8 CD34 KIT MLANA MYC RB1 TFE3
2 neoplasm MP:0002006 9.63 AFP CD34 KIT MYC RB1 TSC2
3 normal MP:0002873 9.43 KIT MTOR MYC RB1 TFE3 TSC2
4 pigmentation MP:0001186 9.02 KIT MLANA MYC RB1 TFE3

Drugs & Therapeutics for Hepatic Angiomyolipoma

Search Clinical Trials , NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

40
Liver, Small Intestine, Colon, Lung, Testes

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 231)
# Title Authors PMID Year
1
Contrast-enhanced sonographic appearances of two primary hepatic epithelioid angiomyolipomas. 61
32012287 2020
2
Hepatic Angiomyolipoma: Clinical Features and Imaging Findings of Quantitative Contrast-Enhanced Ultrasound Perfusion Analysis and Magnetic Resonance Imaging. 61
32383807 2020
3
Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome. 61
31619346 2020
4
Identification of a specific ultrasonographic finding for differentiating hepatic angiomyolipoma from hepatocellular carcinoma. 61
31812881 2020
5
Benign liver angiomyolipoma: a case study. 61
32349491 2020
6
Pedunculated hepatic angiomyolipoma: A rare entity. 61
31653540 2019
7
Uncommon imaging evolutions of focal liver lesions in cirrhosis. 61
31222462 2019
8
Hepatic angiomyolipoma with early drainage veins into the hepatic and portal vein. 61
30762212 2019
9
Hepatic Angiomyolipoma Having FDG Uptake at the Similar Level of the Normal Liver Parenchyma. 61
31135516 2019
10
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. 61
29392818 2019
11
Hepatic angiomyolipoma detected using computed tomography. 61
29392859 2019
12
Giant hepatic angiomyolipoma: a case report. 61
31131134 2019
13
The differential enhancement pattern of contrast enhanced ultrasound and magnetic resonance imaging characteristics in hepatic angiomyolipoma: 7 case reports. 61
30010112 2019
14
Hepatic Epithelioid Angiomyolipoma Treated with Laparoscopic Resection: Case Report and Review of the Literature. 61
31355023 2019
15
Retinal astrocytic hamartoma in tuberous sclerosis complex in an elderly person: a case report. 61
30541513 2018
16
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. 61
29241297 2018
17
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. 61
29512829 2018
18
Hepatic Angiomyolipoma Staining in the Post-vascular Phase of Contrast-enhanced Ultrasound Due to the Presence of Macrophages. 61
29279500 2018
19
Hepatic myomatous angiomyolipoma diagnosedpreoperatively from specific imaging features: A case report. 61
30273908 2018
20
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. 61
28122404 2018
21
Comparison of MRI Features of Epithelioid Hepatic Angiomyolipoma and Hepatocellular Carcinoma: Imaging Data From Two Centers. 61
30619742 2018
22
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex. 61
29237943 2017
23
Angiomyolipoma of the Liver: A Rare Benign Tumor Treated with a Laparoscopic Approach for the First Time. 61
29102941 2017
24
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. 61
28809731 2017
25
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. 61
31153535 2017
26
Management of hepatic angiomyolipoma: A systematic review. 61
28177188 2017
27
A case of ruptured hepatic angiomyolipoma in a young male. 61
28449573 2017
28
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. 61
28327196 2017
29
CD68-Positive Cells in Hepatic Angiomyolipoma. 61
28030864 2017
30
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. 61
27248975 2016
31
[Hepatic angiomyolipoma: a clinicopathologic features and prognosis analysis of 182 cases]. 61
26956960 2016
32
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. 61
26867906 2016
33
An Unusual Variant of Hepatic Inflammatory Angiomyolipoma: Report of a Rare Entity. 61
26927347 2016
34
Angiomyolipoma in a Patient with Situs Inversus Totalis: Managing Two Rare Diseases. 61
27525134 2016
35
Epithelioid angiomyolipoma of the liver: Clinicopathological correlation in a series of 4 cases. 61
26765232 2016
36
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. 61
26943379 2015
37
A Case of Exophytic Angiomyolipoma of the Liver. 61
26730108 2015
38
The "peripheral washout sign" in focal hepatic lesions: not always an MRI sign of malignancy. 61
25951769 2015
39
Alterations of the mTOR pathway in hepatic angiomyolipoma with emphasis on the epithelioid variant and loss of heterogeneity of TSC1/TSC2. 61
25234729 2015
40
Computed tomographic features of lymphangioleiomyomatosis: evaluation in 138 patients. 61
25544557 2015
41
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: a case report. 61
25834347 2015
42
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. 61
25805953 2015
43
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. 61
25803731 2015
44
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. 61
26617933 2015
45
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. 61
26147859 2015
46
Hepatic angiomyolipoma with special attention to radiologic imaging. 61
26366342 2015
47
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. 61
26114004 2015
48
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. 61
25526436 2014
49
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. 61
26184024 2014
50
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. 61
24314304 2014

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 TSC2 RB1 MYC MTOR KIT
2 12.6 RB1 MYC MTOR KIT
3
Show member pathways
12.53 RB1 MYC MTOR KIT
4
Show member pathways
12.51 TSC2 RB1 MYC MTOR KIT
5
Show member pathways
12 TSC2 RB1 MYC MTOR
6 11.84 TSC2 RB1 AFP
7 11.8 TSC2 MYC MTOR
8 11.76 KIT CEACAM3 CD34
9 11.65 TSC2 RB1 MYC MTOR
10 11.55 MYC KIT CD34
11 11.5 TFE3 RB1 MYC
12 11.45 MYC MTOR KIT
13 11.44 TSC2 RB1 MYC MTOR
14 11.41 RB1 MYC MTOR
15 11.22 TSC2 MYC MTOR
16 11.07 TSC2 MTOR
17 11.06 TSC2 MYC MTOR
18 11.02 TSC2 MTOR
19 10.97 TSC2 RB1 MYC MTOR
20 10.91 RB1 MYC

GO Terms for Hepatic Angiomyolipoma

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 MYC MTOR KIT CD34
2 cell cycle arrest GO:0007050 9.43 RB1 MYC MTOR
3 tissue homeostasis GO:0001894 9.4 RB1 CD34
4 positive regulation of glial cell proliferation GO:0060252 9.32 MYC MTOR
5 regulation of osteoclast differentiation GO:0045670 9.16 TFE3 MTOR
6 energy reserve metabolic process GO:0006112 8.96 MYC MTOR
7 anoikis GO:0043276 8.62 TSC2 MTOR

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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