MCID: HPT006
MIFTS: 32

Hepatic Angiomyolipoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 50 C27485
UMLS 72 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to angiomyolipoma and kidney angiomyolipoma. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Human cytomegalovirus infection. Affiliated tissues include liver, colon and lung, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 angiomyolipoma 31.8 TSC2 MTOR
2 kidney angiomyolipoma 30.7 TSC2 MTOR
3 tuberous sclerosis 1 30.6 TSC2 MTOR
4 lymphangioleiomyomatosis 30.2 TSC2 MTOR
5 hepatocellular carcinoma 29.3 RB1 MYC MTOR AFP
6 tuberous sclerosis 10.6
7 hemangioma 10.4
8 rare soft tissue tumor 10.2
9 cavernous hemangioma 10.2
10 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
11 subependymal glioma 10.2 TSC2 MTOR
12 benign ependymoma 10.2 TSC2 MTOR
13 hemimegalencephaly 10.1 MYC MTOR
14 kidney benign neoplasm 10.1 TSC2 MTOR
15 rare tumor 10.1
16 47,xyy 10.1
17 adenoma 10.1
18 hepatocellular adenoma 10.1
19 plasmablastic lymphoma 10.1 MYC MTOR
20 germ cell and embryonal cancer 10.1 MYC AFP
21 subependymal giant cell astrocytoma 10.1 TSC2 MTOR
22 central nervous system benign neoplasm 10.1 TSC2 MTOR
23 focal cortical dysplasia, type ii 10.1 TSC2 MTOR
24 hemangioma of liver 10.0
25 tuberous sclerosis 2 10.0 TSC2 MTOR
26 ewing's family of tumors 10.0 RB1 MTOR
27 suppressor of tumorigenicity 3 10.0 RB1 MYC
28 retinal cancer 9.9 RB1 MYC
29 cerebrofacial arteriovenous metameric syndrome 9.9
30 back pain 9.9
31 fatty liver disease 9.9
32 liver inflammatory pseudotumor 9.9
33 ulcerative colitis 9.9
34 lung disease 9.9
35 hepatoblastoma 9.9
36 giant hemangioma 9.9
37 liver cirrhosis 9.9
38 clear cell renal cell carcinoma 9.9
39 thrombophlebitis 9.9
40 mesenchymal cell neoplasm 9.9
41 purpura 9.9
42 rhabdomyosarcoma 9.9
43 neurilemmoma 9.9
44 interstitial lung disease 9.9
45 hepatitis b 9.9
46 cholecystitis 9.9
47 melanoma 9.9
48 viral hepatitis 9.9
49 hepatitis c 9.9
50 leiomyoma 9.9

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 AFP MTOR MYC RB1 TSC2
2 liver/biliary system MP:0005370 9.26 AFP MYC RB1 TSC2
3 neoplasm MP:0002006 8.92 AFP MYC RB1 TSC2

Drugs & Therapeutics for Hepatic Angiomyolipoma

Search Clinical Trials , NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

41
Liver, Colon, Lung, Testes, Small Intestine

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 225)
# Title Authors PMID Year
1
Uncommon imaging evolutions of focal liver lesions in cirrhosis. 38
31222462 2019
2
Hepatic angiomyolipoma with early drainage veins into the hepatic and portal vein. 38
30762212 2019
3
Hepatic Angiomyolipoma Having FDG Uptake at the Similar Level of the Normal Liver Parenchyma. 38
31135516 2019
4
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. 38
29392818 2019
5
Hepatic angiomyolipoma detected using computed tomography. 38
29392859 2019
6
Giant hepatic angiomyolipoma: a case report. 38
31131134 2019
7
Hepatic Epithelioid Angiomyolipoma Treated with Laparoscopic Resection: Case Report and Review of the Literature. 38
31355023 2019
8
The differential enhancement pattern of contrast enhanced ultrasound and magnetic resonance imaging characteristics in hepatic angiomyolipoma: 7 case reports. 38
30010112 2019
9
Retinal astrocytic hamartoma in tuberous sclerosis complex in an elderly person: a case report. 38
30541513 2018
10
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. 38
29241297 2018
11
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. 38
29512829 2018
12
Hepatic Angiomyolipoma Staining in the Post-vascular Phase of Contrast-enhanced Ultrasound Due to the Presence of Macrophages. 38
29279500 2018
13
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. 38
28122404 2018
14
Hepatic myomatous angiomyolipoma diagnosedpreoperatively from specific imaging features: A case report. 38
30273908 2018
15
Comparison of MRI Features of Epithelioid Hepatic Angiomyolipoma and Hepatocellular Carcinoma: Imaging Data From Two Centers. 38
30619742 2018
16
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex. 38
29237943 2017
17
Angiomyolipoma of the Liver: A Rare Benign Tumor Treated with a Laparoscopic Approach for the First Time. 38
29102941 2017
18
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. 38
31153535 2017
19
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. 38
28809731 2017
20
Management of hepatic angiomyolipoma: A systematic review. 38
28177188 2017
21
A case of ruptured hepatic angiomyolipoma in a young male. 38
28449573 2017
22
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. 38
28327196 2017
23
CD68-Positive Cells in Hepatic Angiomyolipoma. 38
28030864 2017
24
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. 38
27248975 2016
25
[Hepatic angiomyolipoma: a clinicopathologic features and prognosis analysis of 182 cases]. 38
26956960 2016
26
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. 38
26867906 2016
27
Angiomyolipoma in a Patient with Situs Inversus Totalis: Managing Two Rare Diseases. 38
27525134 2016
28
An Unusual Variant of Hepatic Inflammatory Angiomyolipoma: Report of a Rare Entity. 38
26927347 2016
29
Epithelioid angiomyolipoma of the liver: Clinicopathological correlation in a series of 4 cases. 38
26765232 2016
30
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. 38
26943379 2015
31
A Case of Exophytic Angiomyolipoma of the Liver. 38
26730108 2015
32
The "peripheral washout sign" in focal hepatic lesions: not always an MRI sign of malignancy. 38
25951769 2015
33
Alterations of the mTOR pathway in hepatic angiomyolipoma with emphasis on the epithelioid variant and loss of heterogeneity of TSC1/TSC2. 38
25234729 2015
34
Computed tomographic features of lymphangioleiomyomatosis: evaluation in 138 patients. 38
25544557 2015
35
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. 38
25805953 2015
36
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: a case report. 38
25834347 2015
37
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. 38
25803731 2015
38
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. 38
26147859 2015
39
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. 38
26617933 2015
40
Hepatic angiomyolipoma with special attention to radiologic imaging. 38
26366342 2015
41
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. 38
26114004 2015
42
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. 38
25526436 2014
43
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. 38
24314304 2014
44
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. 38
26184024 2014
45
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. 38
26185889 2014
46
Rare benign tumors of the liver: still rare? 38
24510731 2014
47
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. 38
24670055 2014
48
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. 38
23679956 2014
49
Ruptured hepatic epithelioid angiomyolipoma: a case report and literature review. 38
24987358 2014
50
A case of multiple hepatic angiomyolipomas with high (18) F-fluorodeoxyglucose uptake. 38
24885757 2014

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 TSC2 RB1 MYC MTOR
2
Show member pathways
12.63 TSC2 RB1 MYC MTOR
3 12.56 RB1 MYC MTOR
4
Show member pathways
12.52 TSC2 RB1 MYC MTOR
5
Show member pathways
12.49 RB1 MYC MTOR
6
Show member pathways
12.42 TSC2 RB1 MTOR
7
Show member pathways
12.12 TSC2 MYC MTOR
8
Show member pathways
12.09 TSC2 RB1 MYC
9 11.83 TSC2 MYC MTOR
10
Show member pathways
11.81 TSC2 RB1 MYC MTOR
11 11.75 TSC2 RB1 AFP
12 11.68 TSC2 MYC MTOR
13 11.66 TSC2 RB1 MYC MTOR
14 11.64 RB1 MYC
15 11.62 RB1 MYC
16 11.6 TSC2 MTOR
17
Show member pathways
11.6 TSC2 MTOR
18 11.52 RB1 MYC
19 11.52 RB1 MYC
20
Show member pathways
11.47 MYC MTOR
21 11.47 MYC MTOR
22 11.46 MYC MTOR
23 11.44 TSC2 RB1 MYC MTOR
24 11.41 TSC2 MYC
25 11.41 RB1 MYC MTOR
26 11.4 TSC2 MTOR
27 11.3 RB1 MYC
28 11.28 MYC MTOR
29 11.27 RB1 MYC
30 11.27 TSC2 MYC MTOR
31 11.26 TSC2 MTOR
32 11.16 RB1 MYC
33 11.1 TSC2 MTOR
34 11.06 TSC2 MYC MTOR
35 11.05 TSC2 MTOR
36 11 TSC2 MTOR
37 10.97 TSC2 RB1 MYC MTOR
38 10.87 RB1 MYC

GO Terms for Hepatic Angiomyolipoma

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.48 RB1 MYC
2 regulation of cell growth GO:0001558 9.46 RB1 MTOR
3 negative regulation of protein kinase activity GO:0006469 9.43 TSC2 RB1
4 positive regulation of translation GO:0045727 9.4 MYC MTOR
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.37 MYC MTOR
6 regulation of mitotic cell cycle GO:0007346 9.32 RB1 MYC
7 positive regulation of glial cell proliferation GO:0060252 9.26 MYC MTOR
8 energy reserve metabolic process GO:0006112 9.16 MYC MTOR
9 cell cycle arrest GO:0007050 9.13 RB1 MYC MTOR
10 anoikis GO:0043276 8.62 TSC2 MTOR

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoprotein binding GO:0051219 8.62 RB1 MTOR

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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