MCID: HPT006
MIFTS: 37

Hepatic Angiomyolipoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 51 C27485
UMLS 74 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to angiomyolipoma and tuberous sclerosis 1. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are ERK Signaling and Human cytomegalovirus infection. Affiliated tissues include kidney, liver and testis, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 angiomyolipoma 30.8 KIT MTOR TSC2
2 tuberous sclerosis 1 30.2 MTOR TSC2
3 lymphangioleiomyomatosis 30.0 MTOR TSC2
4 hepatocellular carcinoma 29.9 AFP MTOR MYC RB1
5 tuberous sclerosis 10.4
6 suppressor of tumorigenicity 3 10.1 MYC RB1
7 germ cell and embryonal cancer 10.1 AFP MYC
8 retinal cancer 10.1 MYC RB1
9 kidney angiomyolipoma 10.1 MTOR TSC2
10 subependymal glioma 10.0 MTOR TSC2
11 benign ependymoma 10.0 MTOR TSC2
12 ocular cancer 10.0 MYC RB1
13 kidney benign neoplasm 10.0 MTOR TSC2
14 hemimegalencephaly 10.0 MTOR MYC
15 hemangioma 10.0
16 plasmablastic lymphoma 10.0 MTOR MYC
17 subependymal giant cell astrocytoma 10.0 MTOR TSC2
18 central nervous system benign neoplasm 10.0 MTOR TSC2
19 focal cortical dysplasia, type ii 10.0 MTOR TSC2
20 mixed germ cell tumor 10.0 AFP KIT
21 intratubular embryonal carcinoma 10.0 AFP KIT
22 endometrial small cell carcinoma 10.0 AFP KIT
23 rete testis adenocarcinoma 10.0 AFP KIT
24 testicular infarct 10.0 AFP KIT
25 mediastinal cancer 10.0 AFP KIT
26 embryoma 10.0 AFP KIT
27 rete testis neoplasm 10.0 AFP KIT
28 extragonadal seminoma 10.0 AFP KIT
29 seminoma 10.0 AFP KIT
30 tuberous sclerosis 2 10.0 MTOR TSC2
31 mixed cell type cancer 10.0 AFP KIT
32 dysgerminoma of ovary 9.9 AFP KIT
33 dysgerminoma 9.9 AFP KIT
34 nervous system cancer 9.9 MYC RB1
35 perivascular epithelioid cell tumor 9.9 KIT TSC2
36 fibrosarcoma of bone 9.9 KIT MYC
37 neurofibromatosis, type iv, of riccardi 9.9
38 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
39 alacrima, achalasia, and mental retardation syndrome 9.9
40 arteriovenous fistula 9.9
41 hepatitis 9.9
42 hepatitis b 9.9
43 ulcerative colitis 9.9
44 colitis 9.9
45 disseminated intravascular coagulation 9.9
46 melanoma 9.9
47 neurilemmoma 9.9
48 rhabdomyosarcoma 9.9
49 cavernous hemangioma 9.9
50 giant hemangioma 9.9

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

GenomeRNAi Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.4 MTOR
2 Decreased viability GR00221-A-1 9.4 KIT MTOR MYC
3 Decreased viability GR00221-A-3 9.4 MYC
4 Decreased viability GR00221-A-4 9.4 MTOR
5 Decreased viability GR00301-A 9.4 KIT
6 Decreased viability GR00342-S-1 9.4 MTOR
7 Decreased viability GR00342-S-2 9.4 MTOR
8 Decreased viability GR00402-S-2 9.4 KIT MTOR MYC

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 AFP KIT MTOR MYC RB1 TSC2
2 endocrine/exocrine gland MP:0005379 9.97 AFP KIT MTOR MYC RB1 TSC2
3 homeostasis/metabolism MP:0005376 9.95 AFP KIT MTOR MYC RB1 TSC2
4 cardiovascular system MP:0005385 9.92 KIT MTOR MYC RB1 TSC2
5 embryo MP:0005380 9.91 KIT MTOR MYC RB1 TSC2
6 mortality/aging MP:0010768 9.91 AFP KIT MTOR MYC RB1 TSC2
7 liver/biliary system MP:0005370 9.85 AFP KIT MYC RB1 TSC2
8 neoplasm MP:0002006 9.77 AFP KIT MYC RB1 TSC2
9 muscle MP:0005369 9.71 KIT MTOR MYC RB1
10 normal MP:0002873 9.65 KIT MTOR MYC RB1 TSC2
11 no phenotypic analysis MP:0003012 9.62 KIT MTOR MYC RB1
12 pigmentation MP:0001186 9.33 KIT MYC RB1
13 renal/urinary system MP:0005367 9.26 KIT MTOR RB1 TSC2
14 reproductive system MP:0005389 9.02 AFP KIT MYC RB1 TSC2

Drugs & Therapeutics for Hepatic Angiomyolipoma

Search Clinical Trials , NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

42
Kidney, Liver, Testis, Testes, Small Intestine, Bone, Thymus

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 144)
# Title Authors Year
1
The differential enhancement pattern of contrast enhanced ultrasound and magnetic resonance imaging characteristics in hepatic angiomyolipoma: 7 case reports. ( 30010112 )
2019
2
Hepatic angiomyolipoma with early drainage veins into the hepatic and portal vein. ( 30762212 )
2019
3
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. ( 29392818 )
2018
4
Hepatic angiomyolipoma detected using computed tomography. ( 29392859 )
2018
5
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. ( 29512829 )
2018
6
Comparison of MRI Features of Epithelioid Hepatic Angiomyolipoma and Hepatocellular Carcinoma: Imaging Data From Two Centers. ( 30619742 )
2018
7
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. ( 28122404 )
2018
8
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. ( 29241297 )
2018
9
Hepatic Angiomyolipoma Staining in the Post-vascular Phase of Contrast-enhanced Ultrasound Due to the Presence of Macrophages. ( 29279500 )
2018
10
Management of hepatic angiomyolipoma: A systematic review. ( 28177188 )
2017
11
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. ( 28327196 )
2017
12
A case of ruptured hepatic angiomyolipoma in a young male. ( 28449573 )
2017
13
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. ( 28809731 )
2017
14
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex. ( 29237943 )
2017
15
CD68-Positive Cells in Hepatic Angiomyolipoma. ( 28030864 )
2017
16
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. ( 26867906 )
2016
17
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. ( 27248975 )
2016
18
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. ( 26617933 )
2015
19
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. ( 26943379 )
2015
20
Alterations of the mTOR pathway in hepatic angiomyolipoma with emphasis on the epithelioid variant and loss of heterogeneity of TSC1/TSC2. ( 25234729 )
2015
21
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25803731 )
2015
22
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. ( 25805953 )
2015
23
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: a case report. ( 25834347 )
2015
24
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. ( 26114004 )
2015
25
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. ( 26147859 )
2015
26
Hepatic angiomyolipoma with special attention to radiologic imaging. ( 26366342 )
2015
27
Hepatic angiomyolipoma: what management? ( 25073214 )
2014
28
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25526436 )
2014
29
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. ( 26184024 )
2014
30
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. ( 26185889 )
2014
31
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. ( 23679956 )
2014
32
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. ( 24314304 )
2014
33
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. ( 24389893 )
2014
34
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. ( 24670055 )
2014
35
Fat-deficient hepatic angiomyolipoma: a radiological challenge. ( 23701714 )
2013
36
Is surgery necessary for patients with hepatic angiomyolipoma? Retrospective analysis from eight Chinese cases. ( 23731017 )
2013
37
Immunohistochemical character of hepatic angiomyolipoma: for its management. ( 23864864 )
2013
38
Hepatic angiomyolipoma: a case report with diagnostic challenge. ( 24152510 )
2013
39
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. ( 22996326 )
2013
40
Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases. ( 23292871 )
2013
41
Large hepatic angiomyolipoma. ( 23433965 )
2013
42
Incidental finding of a hepatic angiomyolipoma. ( 27330622 )
2013
43
Hepatic angiomyolipoma: contrast patterns with SonoVue-enhanced real-time gray-scale ultrasonography. ( 22524813 )
2012
44
Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsy. ( 22949933 )
2012
45
Sporadic exophytic hepatic angiomyolipoma. ( 23060385 )
2012
46
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. ( 23091816 )
2012
47
Hepatic angiomyolipoma: diagnostic findings and management. ( 23320180 )
2012
48
Diagnosis and treatment of hepatic angiomyolipoma. ( 24570900 )
2012
49
A case of hepatic angiomyolipoma which was misdiagnosed as hepatocellular carcinoma in a hepatitis B carrier. ( 25374707 )
2012
50
Preoperative radiological characterization of hepatic angiomyolipoma using magnetic resonance imaging and contrast-enhanced ultrasonography: a case report. ( 21943146 )
2011

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 KIT MTOR MYC RB1 TSC2
2
Show member pathways
12.66 MTOR MYC RB1 TSC2
3 12.55 KIT MTOR MYC RB1
4
Show member pathways
12.55 KIT MTOR MYC RB1 TSC2
5
Show member pathways
12.47 KIT MTOR TSC2
6
Show member pathways
12.46 KIT MTOR MYC RB1
7
Show member pathways
12.44 MTOR RB1 TSC2
8
Show member pathways
12.4 KIT MTOR MYC RB1 TSC2
9
Show member pathways
12.28 MTOR MYC RB1
10
Show member pathways
12.17 KIT MTOR TSC2
11
Show member pathways
12.14 MTOR MYC TSC2
12
Show member pathways
12.12 MYC RB1 TSC2
13
Show member pathways
12.01 KIT MYC RB1
14
Show member pathways
11.89 MTOR MYC RB1 TSC2
15 11.88 MTOR MYC TSC2
16 11.83 AFP RB1 TSC2
17 11.75 MTOR MYC TSC2
18 11.66 MTOR MYC RB1 TSC2
19 11.57 KIT MYC
20 11.54 MYC RB1
21 11.54 MYC RB1
22
Show member pathways
11.49 MTOR MYC
23 11.49 MTOR MYC RB1
24 11.48 MTOR MYC
25 11.45 KIT MTOR MYC
26 11.44 MTOR TSC2
27 11.44 MYC TSC2
28 11.44 MTOR MYC RB1 TSC2
29 11.33 MYC RB1
30 11.33 MTOR MYC TSC2
31 11.31 MTOR MYC
32 11.3 MTOR TSC2
33 11.3 MYC RB1
34 11.19 MYC RB1
35 11.17 MTOR MYC TSC2
36 11.14 MTOR TSC2
37 11.08 MTOR TSC2
38 11.02 MTOR TSC2
39 10.97 MTOR MYC RB1 TSC2
40 10.9 MYC RB1

GO Terms for Hepatic Angiomyolipoma

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 KIT MTOR MYC
2 regulation of cell growth GO:0001558 9.52 MTOR RB1
3 negative regulation of protein kinase activity GO:0006469 9.51 RB1 TSC2
4 positive regulation of translation GO:0045727 9.49 MTOR MYC
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 MTOR MYC
6 visual learning GO:0008542 9.43 KIT MTOR
7 ovarian follicle development GO:0001541 9.4 KIT MYC
8 regulation of mitotic cell cycle GO:0007346 9.37 MYC RB1
9 digestive tract development GO:0048565 9.32 KIT RB1
10 positive regulation of glial cell proliferation GO:0060252 9.26 MTOR MYC
11 energy reserve metabolic process GO:0006112 9.16 MTOR MYC
12 cell cycle arrest GO:0007050 9.13 MTOR MYC RB1
13 anoikis GO:0043276 8.62 MTOR TSC2

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoprotein binding GO:0051219 8.62 MTOR RB1

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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