MCID: HPT006
MIFTS: 29

Hepatic Angiomyolipoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases
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Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3317
NCIt 49 C27485
UMLS 71 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary: Hepatic Angiomyolipoma is related to tuberous sclerosis 1 and tuberous sclerosis. An important gene associated with Hepatic Angiomyolipoma is MLANA (Melan-A), and among its related pathways/superpathways are Melanocyte Development and Pigmentation and LKB1 signaling events. Affiliated tissues include liver, colon and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 tuberous sclerosis 1 31.2 TSC2 TSC1
2 tuberous sclerosis 30.9 TSC2 TSC1 MLANA
3 congenital heart defects, hamartomas of tongue, and polysyndactyly 30.6 TSC2 TSC1
4 cavernous hemangioma 30.2 CD34 AFP
5 angiomyolipoma 30.2 TSC2 TSC1 TFE3 MLANA MITF KIT
6 mesenchymal cell neoplasm 30.2 TFE3 MLANA KIT CD34
7 liver inflammatory pseudotumor 30.1 CD34 AFP
8 cystic teratoma 30.1 CD34 AFP
9 hemangioma 30.0 TSC2 TSC1 KIT CD34
10 lipomatosis, multiple 29.9 MLANA KIT CD34 AFP
11 kidney angiomyolipoma 29.8 TSC2 TSC1 TFE3 MLANA MITF
12 dowling-degos disease 1 29.8 MITF KIT
13 leiomyoma 29.6 TSC2 KIT CD34
14 liver lipoma 29.6 TSC2 TSC1 CD34 AFP
15 gastrointestinal stromal tumor 29.5 MLANA KIT CD34
16 epithelioid type angiomyolipoma 29.5 TSC2 TSC1 TFE3 MLANA MITF
17 neurilemmoma 29.2 MLANA MITF KIT CD34
18 renal cell carcinoma, nonpapillary 28.3 TSC2 TSC1 TFE3 MITF KIT HNF1A
19 tuberous sclerosis 2 10.6
20 hepatocellular carcinoma 10.3
21 testicular granulosa cell tumor 10.3 MLANA AFP
22 rare tumor 10.3
23 ovarian cystic teratoma 10.3 MLANA AFP
24 mature teratoma of the ovary 10.3 MLANA AFP
25 fallopian tube benign neoplasm 10.3 TSC2 AFP
26 juvenile type testicular granulosa cell tumor 10.2 MLANA AFP
27 multilocular clear cell renal cell carcinoma 10.2 TSC2 TSC1
28 malignant granular cell myoblastoma 10.2 TFE3 MLANA
29 rare soft tissue tumor 10.2
30 penis sarcoma 10.2 MLANA CD34
31 malignant leptomeningeal tumor 10.2 MLANA MITF
32 meningeal melanoma 10.2 MLANA MITF
33 ovarian solid teratoma 10.2 CD34 AFP
34 pigmented basal cell carcinoma 10.2 MLANA MITF
35 focal cortical dysplasia, type ii 10.2 TSC2 TSC1
36 colonic lymphangioma 10.2 CD34 AFP
37 subependymal glioma 10.2 TSC2 TSC1
38 spinal cord melanoma 10.2 MLANA MITF
39 scrotum neoplasm 10.2 CD34 AFP
40 benign ependymoma 10.2 TSC2 TSC1
41 epithelioid malignant peripheral nerve sheath tumor 10.2 MLANA CD34
42 chorioangioma 10.2 CD34 AFP
43 malignant triton tumor 10.2 MLANA CD34
44 peliosis hepatis 10.2 CD34 AFP
45 malignant mesenchymoma 10.2 CD34 AFP
46 sarcomatoid squamous cell skin carcinoma 10.1 MLANA CD34
47 cowden syndrome 4 10.1 TSC2 MITF
48 hereditary renal cell carcinoma 10.1 TSC2 TFE3
49 epithelioid cell melanoma 10.1 MLANA MITF
50 solitary fibrous tumor/hemangiopericytoma 10.1 MLANA CD34

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

GenomeRNAi Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.58 TSC2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.58 TSC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.58 MITF TSC1 TSC2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.58 MITF
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.58 TSC2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-15 9.58 MITF
7 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.58 MITF
8 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.58 TSC2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 MITF
10 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.58 MITF
11 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.58 TSC1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.58 TSC2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.58 TSC2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.58 MITF
15 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.58 TSC2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-95 9.58 TSC2

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 9.65 KIT MITF MLANA TFE3 TSC1
2 neoplasm MP:0002006 9.55 AFP CD34 KIT TSC1 TSC2
3 liver/biliary system MP:0005370 9.43 AFP HNF1A KIT MITF TSC1 TSC2
4 integument MP:0010771 9.23 CD34 HNF1A KIT MITF MLANA TFE3

Drugs & Therapeutics for Hepatic Angiomyolipoma

Search Clinical Trials, NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

Organs/tissues related to Hepatic Angiomyolipoma:

MalaCards : Liver, Colon, Lung

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 248)
# Title Authors PMID Year
1
Standardization of laparoscopic anatomic liver resection of segment 2 by the Glissonean approach. 62
36123546 2022
2
Fat in mass in primary liver lesions: are usual MRI diagnostic criteria of both malignant and benign liver lesions still applicable? 62
35672475 2022
3
Fine needle aspiration of hepatic angiomyolipoma with extramedullary hematopoiesis: A case report. 62
35075721 2022
4
Hepatic epithelioid angiomyolipoma mimicking hepatocellular carcinoma on MR and 18F-FDG PET/CT imaging: A case report and literature review. 62
35913867 2022
5
Giant hepatic angiomyolipoma presenting with severe anemia: A surgical case report and review of literature. 62
35658280 2022
6
Diagnosis and surgical treatment of a rare hepatic angiomyolipoma with internal hemorrhage. 62
34845127 2021
7
Indeterminate liver lesions on gadoxetic acid-enhanced magnetic resonance imaging of the liver: Case-based radiologic-pathologic review. 62
34630876 2021
8
Hepatic angiomyolipoma with predominant epithelioid component: Diagnostic clues on aspiration and core needle biopsies. 62
33373500 2021
9
Clinical characteristics and outcomes of patients with hepatic angiomyolipoma: A literature review. 62
34040323 2021
10
Clinicopathological correlation and post-resection outcomes of hepatic angiomyolipoma. 62
34053924 2021
11
Laparoscopic Resection of a Hepatic Epithelioid Angiomyolipoma Revealed by Indocyanine Green Fluorescence Imaging. 62
34058831 2021
12
Clinical and Contrast-enhanced Ultrasound Characteristics of Epithelioid and Classic Hepatic Angiomyolipoma: Comparison With Alpha-fetoprotein-negative Hepatocellular Carcinoma. 62
33353786 2021
13
Laparoscopic hepatectomy for hepatic angiomyolipoma with preoperative diagnosis of other malignancy: a report of 2 cases. 62
33555457 2021
14
Beware the "other AML": hepatic angiomyolipoma with extensive extramedullary hematopoiesis. 62
33570613 2021
15
Hepatic Angiomyolipoma: Clinical Features and Imaging Findings of Quantitative Contrast-Enhanced Ultrasound Perfusion Analysis and Magnetic Resonance Imaging. 62
32383807 2020
16
[Angiomyolipoma of the liver-a case report and review of the literature]. 62
32955648 2020
17
A huge hepatic angiomyolipoma with growth during 5 years of follow-up. 62
33005323 2020
18
Contrast-enhanced sonographic appearances of two primary hepatic epithelioid angiomyolipomas. 62
32012287 2020
19
Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome. 62
31619346 2020
20
Identification of a specific ultrasonographic finding for differentiating hepatic angiomyolipoma from hepatocellular carcinoma. 62
31812881 2020
21
Hepatic angiomyolipoma resected by eft hepatectomy: Case report. 62
32963382 2020
22
Benign liver angiomyolipoma: a case study. 62
32349491 2020
23
Hepatic angiomyolipoma: A case report and literature review. 62
33212308 2020
24
Pedunculated hepatic angiomyolipoma: A rare entity. 62
31653540 2019
25
Uncommon imaging evolutions of focal liver lesions in cirrhosis. 62
31222462 2019
26
Hepatic angiomyolipoma with early drainage veins into the hepatic and portal vein. 62
30762212 2019
27
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. 62
29392818 2019
28
Hepatic Angiomyolipoma Having FDG Uptake at the Similar Level of the Normal Liver Parenchyma. 62
31135516 2019
29
Hepatic angiomyolipoma detected using computed tomography. 62
29392859 2019
30
Giant hepatic angiomyolipoma: a case report. 62
31131134 2019
31
Hepatic Epithelioid Angiomyolipoma Treated with Laparoscopic Resection: Case Report and Review of the Literature. 62
31355023 2019
32
The differential enhancement pattern of contrast enhanced ultrasound and magnetic resonance imaging characteristics in hepatic angiomyolipoma: 7 case reports. 62
30010112 2019
33
Retinal astrocytic hamartoma in tuberous sclerosis complex in an elderly person: a case report. 62
30541513 2018
34
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. 62
29241297 2018
35
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. 62
29512829 2018
36
Hepatic Angiomyolipoma Staining in the Post-vascular Phase of Contrast-enhanced Ultrasound Due to the Presence of Macrophages. 62
29279500 2018
37
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. 62
28122404 2018
38
Comparison of MRI Features of Epithelioid Hepatic Angiomyolipoma and Hepatocellular Carcinoma: Imaging Data From Two Centers. 62
30619742 2018
39
Hepatic myomatous angiomyolipoma diagnosedpreoperatively from specific imaging features: A case report. 62
30273908 2018
40
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex. 62
29237943 2017
41
Angiomyolipoma of the Liver: A Rare Benign Tumor Treated with a Laparoscopic Approach for the First Time. 62
29102941 2017
42
Management of hepatic angiomyolipoma: A systematic review. 62
28177188 2017
43
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. 62
28809731 2017
44
A case of ruptured hepatic angiomyolipoma in a young male. 62
28449573 2017
45
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. 62
28327196 2017
46
CD68-Positive Cells in Hepatic Angiomyolipoma. 62
28030864 2017
47
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. 62
27248975 2016
48
[Hepatic angiomyolipoma: a clinicopathologic features and prognosis analysis of 182 cases]. 62
26956960 2016
49
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. 62
26867906 2016
50
Angiomyolipoma in a Patient with Situs Inversus Totalis: Managing Two Rare Diseases. 62
27525134 2016

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 MITF KIT
2 10.72 TSC2 TSC1
3 10.4 MLANA MITF
4 9.97 TSC2 TSC1

GO Terms for Hepatic Angiomyolipoma

Cellular components related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.92 TSC2 TSC1

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose import GO:0046323 9.26 TSC1 HNF1A
2 regulation of osteoclast differentiation GO:0045670 8.92 TFE3 MITF

Sources for Hepatic Angiomyolipoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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