MCID: HPT006
MIFTS: 33

Hepatic Angiomyolipoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 49 C27485
UMLS 71 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to tuberous sclerosis 1 and hemangioma. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Human cytomegalovirus infection. Affiliated tissues include liver, kidney and lung, and related phenotypes are endocrine/exocrine gland and integument

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 tuberous sclerosis 1 30.2 TSC2 TSC1 MTOR
2 hemangioma 30.2 TSC2 MYC MTOR
3 congenital heart defects, hamartomas of tongue, and polysyndactyly 30.2 TSC2 TSC1
4 lymphangioleiomyomatosis 30.0 TSC2 TSC1 MTOR
5 angiomyolipoma 29.8 TSC2 TSC1 TFE3 MTOR MLANA
6 tuberous sclerosis 29.7 TSC2 TSC1 MYC MTOR MLANA
7 kidney angiomyolipoma 29.6 TSC2 TSC1 MTOR MLANA
8 perivascular epithelioid cell tumor 29.1 TSC2 TFE3 MLANA
9 hepatocellular carcinoma 10.5
10 hepatoid adenocarcinoma 10.3 CEACAM3 AFP
11 malignant leydig cell tumor 10.2 MLANA AFP
12 adult type testicular granulosa cell tumor 10.2 MLANA AFP
13 testicular granulosa cell tumor 10.2 MLANA AFP
14 plasmablastic lymphoma 10.2 MYC MTOR
15 mature teratoma of the ovary 10.2 MLANA AFP
16 ovarian cystic teratoma 10.2 MLANA AFP
17 ovarian wilms' cancer 10.2 MLANA AFP
18 melanoacanthoma 10.2 MTOR MLANA
19 hemimegalencephaly 10.2 MYC MTOR
20 juvenile type testicular granulosa cell tumor 10.2 MLANA AFP
21 suppressor of tumorigenicity 3 10.2 RB1 MYC
22 cavernous hemangioma 10.2
23 rare soft tissue tumor 10.2
24 rare tumor 10.2
25 large cell acanthoma 10.2 MTOR MLANA
26 liver benign neoplasm 10.2 MYC AFP
27 testicular sex cord-stromal neoplasm 10.1 MLANA AFP
28 hepatocellular adenoma 10.1
29 paget disease, extramammary 10.1 MLANA CEACAM3
30 hemangioma of liver 10.0
31 adenoma 10.0
32 47,xyy 10.0
33 lissencephaly with cerebellar hypoplasia 10.0 TSC2 TSC1
34 sex cord-gonadal stromal tumor 10.0 MLANA AFP
35 cholangiocarcinoma 9.9 MTOR CEACAM3 AFP
36 heart cancer 9.9 TSC2 TSC1
37 leiomyosarcoma 9.9 RB1 MTOR MLANA
38 keratosis, seborrheic 9.9 MTOR MLANA
39 lipomatosis, multiple 9.9
40 neurofibromatosis, type iv, of riccardi 9.9
41 dowling-degos disease 1 9.9
42 lymphoma, hodgkin, classic 9.9
43 osteogenic sarcoma 9.9
44 pancreatic cancer 9.9
45 gastrointestinal stromal tumor 9.9
46 hepatitis c virus 9.9
47 leukemia, acute lymphoblastic 9.9
48 alacrima, achalasia, and mental retardation syndrome 9.9
49 pleomorphic lipoma 9.9
50 lymphocytic leukemia 9.9

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 AFP MTOR MYC RB1 TSC1 TSC2
2 integument MP:0010771 9.73 MLANA MYC RB1 TFE3 TSC1 TSC2
3 liver/biliary system MP:0005370 9.55 AFP MYC RB1 TSC1 TSC2
4 neoplasm MP:0002006 9.35 AFP MYC RB1 TSC1 TSC2
5 pigmentation MP:0001186 9.02 MLANA MYC RB1 TFE3 TSC1

Drugs & Therapeutics for Hepatic Angiomyolipoma

Search Clinical Trials , NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

40
Liver, Kidney, Lung, Heart, Small Intestine, Colon, Testes

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 229)
# Title Authors PMID Year
1
Identification of a specific ultrasonographic finding for differentiating hepatic angiomyolipoma from hepatocellular carcinoma. 61
31812881 2020
2
Contrast-enhanced sonographic appearances of two primary hepatic epithelioid angiomyolipomas. 61
32012287 2020
3
Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome. 61
31619346 2019
4
Pedunculated hepatic angiomyolipoma: A rare entity. 61
31653540 2019
5
Uncommon imaging evolutions of focal liver lesions in cirrhosis. 61
31222462 2019
6
Hepatic angiomyolipoma with early drainage veins into the hepatic and portal vein. 61
30762212 2019
7
Hepatic Angiomyolipoma Having FDG Uptake at the Similar Level of the Normal Liver Parenchyma. 61
31135516 2019
8
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. 61
29392818 2019
9
Hepatic angiomyolipoma detected using computed tomography. 61
29392859 2019
10
Giant hepatic angiomyolipoma: a case report. 61
31131134 2019
11
Hepatic Epithelioid Angiomyolipoma Treated with Laparoscopic Resection: Case Report and Review of the Literature. 61
31355023 2019
12
The differential enhancement pattern of contrast enhanced ultrasound and magnetic resonance imaging characteristics in hepatic angiomyolipoma: 7 case reports. 61
30010112 2019
13
Retinal astrocytic hamartoma in tuberous sclerosis complex in an elderly person: a case report. 61
30541513 2018
14
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. 61
29241297 2018
15
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. 61
29512829 2018
16
Hepatic Angiomyolipoma Staining in the Post-vascular Phase of Contrast-enhanced Ultrasound Due to the Presence of Macrophages. 61
29279500 2018
17
Hepatic myomatous angiomyolipoma diagnosedpreoperatively from specific imaging features: A case report. 61
30273908 2018
18
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. 61
28122404 2018
19
Comparison of MRI Features of Epithelioid Hepatic Angiomyolipoma and Hepatocellular Carcinoma: Imaging Data From Two Centers. 61
30619742 2018
20
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex. 61
29237943 2017
21
Angiomyolipoma of the Liver: A Rare Benign Tumor Treated with a Laparoscopic Approach for the First Time. 61
29102941 2017
22
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. 61
31153535 2017
23
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. 61
28809731 2017
24
Management of hepatic angiomyolipoma: A systematic review. 61
28177188 2017
25
A case of ruptured hepatic angiomyolipoma in a young male. 61
28449573 2017
26
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. 61
28327196 2017
27
CD68-Positive Cells in Hepatic Angiomyolipoma. 61
28030864 2017
28
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. 61
27248975 2016
29
[Hepatic angiomyolipoma: a clinicopathologic features and prognosis analysis of 182 cases]. 61
26956960 2016
30
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. 61
26867906 2016
31
An Unusual Variant of Hepatic Inflammatory Angiomyolipoma: Report of a Rare Entity. 61
26927347 2016
32
Angiomyolipoma in a Patient with Situs Inversus Totalis: Managing Two Rare Diseases. 61
27525134 2016
33
Epithelioid angiomyolipoma of the liver: Clinicopathological correlation in a series of 4 cases. 61
26765232 2016
34
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. 61
26943379 2015
35
A Case of Exophytic Angiomyolipoma of the Liver. 61
26730108 2015
36
The "peripheral washout sign" in focal hepatic lesions: not always an MRI sign of malignancy. 61
25951769 2015
37
Alterations of the mTOR pathway in hepatic angiomyolipoma with emphasis on the epithelioid variant and loss of heterogeneity of TSC1/TSC2. 61
25234729 2015
38
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: a case report. 61
25834347 2015
39
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. 61
25805953 2015
40
Computed tomographic features of lymphangioleiomyomatosis: evaluation in 138 patients. 61
25544557 2015
41
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. 61
26147859 2015
42
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. 61
26617933 2015
43
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. 61
25803731 2015
44
Hepatic angiomyolipoma with special attention to radiologic imaging. 61
26366342 2015
45
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. 61
26114004 2015
46
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. 61
25526436 2014
47
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. 61
24314304 2014
48
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. 61
26184024 2014
49
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. 61
26185889 2014
50
Rare benign tumors of the liver: still rare? 61
24510731 2014

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 TSC2 TSC1 RB1 MYC MTOR
2
Show member pathways
12.67 TSC2 TSC1 RB1 MYC MTOR
3
Show member pathways
12.66 TSC2 RB1 MYC MTOR
4
Show member pathways
12.44 TSC2 TSC1 RB1 MTOR
5
Show member pathways
12.25 TSC2 TSC1 MTOR
6
Show member pathways
12.23 TSC2 TSC1 MTOR
7
Show member pathways
12.22 TSC2 TSC1 MTOR
8
Show member pathways
12.19 TSC2 RB1 MYC
9
Show member pathways
12.14 TSC2 TSC1 MYC MTOR
10
Show member pathways
12.11 TSC2 TSC1 MTOR
11 12.08 TSC2 TSC1 MTOR
12
Show member pathways
12.02 TSC2 TSC1 MTOR
13
Show member pathways
11.95 TSC2 TSC1 MTOR
14
Show member pathways
11.95 TSC2 TSC1 RB1 MYC MTOR
15
Show member pathways
11.94 TSC2 TSC1 MTOR
16 11.89 TSC2 TSC1 MTOR
17 11.86 TSC2 RB1 AFP
18 11.86 TSC2 TSC1 RB1 MYC MTOR
19 11.81 TSC2 MYC MTOR
20 11.74 TSC2 TSC1 RB1 MYC MTOR
21 11.64 TSC2 TSC1 MTOR
22 11.55 TFE3 RB1 MYC
23 11.5 RB1 MYC MTOR
24 11.39 TSC2 TSC1 MTOR
25 11.35 TSC2 TSC1 MYC MTOR
26 11.21 RB1 MYC
27 11.11 TSC2 MTOR
28 11.1 TSC2 TSC1 MTOR
29 11.07 TSC2 TSC1 RB1 MYC MTOR
30 11.06 TSC2 MTOR
31 10.95 RB1 MYC
32 10.88 TSC2 TSC1 MYC MTOR
33 10.84 TSC1 MTOR

GO Terms for Hepatic Angiomyolipoma

Cellular components related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.58 TSC2 TSC1 RB1
2 cell cycle arrest GO:0007050 9.54 RB1 MYC MTOR
3 negative regulation of insulin receptor signaling pathway GO:0046627 9.49 TSC2 TSC1
4 positive regulation of macroautophagy GO:0016239 9.48 TSC2 TSC1
5 negative regulation of TOR signaling GO:0032007 9.46 TSC2 TSC1
6 regulation of protein kinase activity GO:0045859 9.43 TSC1 MTOR
7 regulation of osteoclast differentiation GO:0045670 9.32 TFE3 MTOR
8 energy reserve metabolic process GO:0006112 9.26 MYC MTOR
9 negative regulation of macroautophagy GO:0016242 9.16 TSC1 MTOR
10 anoikis GO:0043276 8.96 TSC2 MTOR
11 negative regulation of cell size GO:0045792 8.62 TSC1 MTOR

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Hsp90 protein binding GO:0051879 8.96 TSC2 TSC1
2 phosphoprotein binding GO:0051219 8.62 RB1 MTOR

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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