MCID: HPT004
MIFTS: 40

Hepatic Coma

Categories: Neuronal diseases, Liver diseases

Aliases & Classifications for Hepatic Coma

MalaCards integrated aliases for Hepatic Coma:

Name: Hepatic Coma 12 55 15 73
Hepatic Encephalopathy 44 73
Hepatocerebral Intoxication 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12550
ICD10 33 K72.91
MeSH 44 D006501
UMLS 73 C0019147

Summaries for Hepatic Coma

MalaCards based summary : Hepatic Coma, also known as hepatic encephalopathy, is related to viral hepatitis and hepatitis a. An important gene associated with Hepatic Coma is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and FOXA2 and FOXA3 transcription factor networks. The drugs Buprenorphine and Diphenhydramine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and colon, and related phenotype is normal.

Related Diseases for Hepatic Coma

Diseases related to Hepatic Coma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 viral hepatitis 31.9 ALB F2 GPT
2 hepatitis a 30.5 ALB F2 GPT
3 esophageal varix 29.9 ALB F2
4 peritonitis 29.6 ALB F2
5 hepatorenal syndrome 29.6 ALB F2
6 schistosomiasis 29.5 ALB F2
7 liver disease 29.5 ALB F2 GPT
8 liver cirrhosis 29.4 ALB F2 GPT
9 portal hypertension 29.0 ALB F2 GPT
10 alcoholic hepatitis 28.8 ALB F2 GPT
11 acute liver failure 28.4 ALB F2 GPT TSPO
12 hepatic encephalopathy 28.1 ALB F2 GPT TSPO
13 hepatitis 11.0
14 hepatoportal sclerosis 10.3 F2 GPT
15 nonalcoholic steatohepatitis 10.3 F2 GPT
16 hepatitis d 10.3 F2 GPT
17 antipyrine metabolism 10.2 ALB F2
18 non-a-e hepatitis 10.2 ALB F2
19 migraine with aura 10.2 F2 SCN1A
20 fournier gangrene 10.2 ALB F2
21 abdominal tuberculosis 10.2 ALB F2
22 splenic disease 10.1 ALB F2
23 ascending cholangitis 10.1 ALB F2
24 cerebritis 10.1
25 hypersplenism 10.1 ALB F2
26 compartment syndrome 10.1 ALB F2
27 hepatic vascular disease 10.1 ALB F2
28 dysfibrinogenemia 10.1 ALB F2
29 vein disease 10.1 ALB F2
30 intermittent claudication 10.1 ALB F2
31 nutritional deficiency disease 10.1 ALB F2
32 biliary tract disease 10.0 ALB F2
33 fascioliasis 10.0 ALB GPT
34 typhoid fever 10.0 ALB F2
35 dengue hemorrhagic fever 10.0 ALB F2
36 homocysteinemia 10.0 ALB F2
37 protein-energy malnutrition 10.0 ALB GPT
38 alcoholic liver cirrhosis 10.0 ALB F2
39 endocarditis 10.0 ALB F2
40 autoimmune hepatitis 10.0 F2 GPT
41 pulmonary embolism 9.9 ALB F2
42 cholelithiasis 9.9 ALB GPT
43 infantile liver failure syndrome 1 9.9
44 encephalopathy 9.9
45 biliary atresia 9.9 ALB GPT
46 peripheral vascular disease 9.8 ALB F2
47 esophagitis 9.8
48 uremia 9.8
49 paracetamol poisoning 9.8
50 eclampsia 9.7 ALB F2

Graphical network of the top 20 diseases related to Hepatic Coma:



Diseases related to Hepatic Coma

Symptoms & Phenotypes for Hepatic Coma

MGI Mouse Phenotypes related to Hepatic Coma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.02 ALB DBI F2 SCN1A TSPO

Drugs & Therapeutics for Hepatic Coma

Drugs for Hepatic Coma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
2
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
3
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
4
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
5
Promethazine Approved, Investigational Phase 4 60-87-7 4927
6
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
7
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
8 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
9 Neurotransmitter Agents Phase 4,Not Applicable
10 Anti-Infective Agents Phase 4,Phase 3
11 Analgesics Phase 4
12 Analgesics, Opioid Phase 4
13 Anesthetics Phase 4
14 Anesthetics, Local Phase 4
15 Anti-Allergic Agents Phase 4
16 Antiemetics Phase 4
17 Antipruritics Phase 4
18 Autonomic Agents Phase 4
19 Buprenorphine, Naloxone Drug Combination Phase 4
20 Central Nervous System Depressants Phase 4
21 Dermatologic Agents Phase 4
22 Histamine Antagonists Phase 4
23 Histamine H1 Antagonists Phase 4
24
Histamine Phosphate Phase 4 51-74-1 65513
25 Hypnotics and Sedatives Phase 4
26 Liver Extracts Phase 4,Not Applicable
27 Narcotic Antagonists Phase 4
28 Narcotics Phase 4
29 Peripheral Nervous System Agents Phase 4
30 Retinol palmitate Phase 4
31 Pharmaceutical Solutions Phase 4,Not Applicable
32 Antidotes Phase 4
33 Antioxidants Phase 4
34 Antiviral Agents Phase 4
35 Expectorants Phase 4
36 N-monoacetylcystine Phase 4
37 Protective Agents Phase 4
38 Respiratory System Agents Phase 4
39 retinol Nutraceutical Phase 4
40
Lactulose Approved Phase 3,Not Applicable 4618-18-2 11333
41
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173
42 Anti-Bacterial Agents Phase 3
43 Nucleic Acid Synthesis Inhibitors Phase 3
44 rifamycin SV Phase 3
45 Rifamycins Phase 3
46
gamma-Aminobutyric acid Approved, Investigational Not Applicable 56-12-2 119
47
Anidulafungin Approved, Investigational 166663-25-8 166548
48
Caspofungin Approved 179463-17-3, 162808-62-0 468682 2826718
49
Micafungin Approved, Investigational 235114-32-6 3081921 477468
50
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects Completed NCT01846455 Phase 4 2.0mg Buprenorphine/0.5mg Naloxone;Promethazine
2 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4 N-acetylcysteine
3 RICE Trial: Rifaximin In Chronic Hepatic Encephalopathy - A Randomized, Controlled Trial Unknown status NCT00364689 Phase 3 Rifaximin alone, Rifaximin combined with Lactulose
4 Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure Unknown status NCT01582087
5 Effects Of Gamma Aminobutyric Acid On The Progression Of New Onset Juvenile Type 1 Diabetes Unknown status NCT01781884 Not Applicable Gamma Aminobutyric Acid (GABA);Placebo
6 Efficacy Study of Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®) Versus Lactulose in Patients With Hepatic Encephalopathy. Completed NCT01283152 Not Applicable Polyethylene glycol 3350-electrolyte solution (GoLYTELY®);Lactulose
7 Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With Echinocandins Terminated NCT01213823
8 Factors Associated With End Stage Liver Disease Terminated NCT01846819
9 Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.) Withdrawn NCT01923376 Not Applicable Lactulose;Polyethylene Glycol 3350

Search NIH Clinical Center for Hepatic Coma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hepatic encephalopathy

Genetic Tests for Hepatic Coma

Anatomical Context for Hepatic Coma

MalaCards organs/tissues related to Hepatic Coma:

41
Liver, Brain, Colon, Kidney, Cortex, Adrenal Cortex, Breast

Publications for Hepatic Coma

Articles related to Hepatic Coma:

(show top 50) (show all 495)
# Title Authors Year
1
Living Donor Liver Transplantation in Acute Liver Failure Patients with Grade IV Encephalopathy: Is Deep Hepatic Coma Still an Absolute Contraindication? A Successful Single-Center Experience. ( 29531210 )
2018
2
Endozepine-4 levels are increased in hepatic coma. ( 26290636 )
2015
3
Effective date of requirement for premarket approval for transilluminator for breast evaluation and sorbent hemoperfusion system (SHS) devices for the treatment of hepatic coma and metabolic disturbances; reclassification of SHS and devices for the treatment of poisoning and drug overdose. Final order. ( 24443766 )
2014
4
50 years ago in The Journal of Pediatrics: Hepatic coma in childhood. ( 24160655 )
2013
5
SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic coma. ( 22504233 )
2012
6
Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy. ( 22490610 )
2012
7
Successful liver transplantation after 21 days of hepatic coma. ( 21946314 )
2011
8
Hepatic coma culminating in severe brain damage in a child with a SCN1A mutation. ( 20392657 )
2010
9
Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study. ( 19357525 )
2009
10
Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. ( 17080254 )
2006
11
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma. ( 16563564 )
2006
12
Acute hepatic failure with deep hepatic coma treated successfully by high-flow continuous hemodiafiltration and living-donor liver transplantation: a case report. ( 12591456 )
2003
13
Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma. ( 12971961 )
2003
14
Compressed spectral arrays of patients with fulminant hepatic failure in hepatic coma undergoing liver transplantation. ( 12099983 )
2002
15
Multisorbent plasma perfusion in fulminant hepatic failure: effects of duration and frequency of treatment in rats with grade III hepatic coma. ( 11251476 )
2001
16
Reversible hepatic coma possibly induced by docetaxel treatment. ( 11305259 )
2001
17
Fulminant hepatitis A in a patient with severe hyperthyroidism: rapid recovery from hepatic coma after plasmapheresis and total thyroidectomy. ( 10843149 )
2000
18
New artificial liver support system (plasma perfusion detoxification) for hepatic coma. 1978. ( 10728498 )
2000
19
Flumazenil for hepatic coma in patients with liver cirrhosis: an Italian multicentre double-blind, placebo-controlled, crossover study. ( 9846248 )
1998
20
Hepatic coma recovered after interventional obliteration for ileocecal-inferior vena cava shunt--report of one case. ( 9383349 )
1997
21
Fatal hepatic coma attributed to paclitaxel. ( 9106649 )
1997
22
Morgagni: his book, vision and views on hepatic coma. ( 8985831 )
1996
23
Flumazenil in cirrhotic patients in hepatic coma: a randomized double-blind placebo-controlled crossover trial. ( 8276366 )
1994
24
Flumazenil for hepatic coma: the elusive wake-up call? ( 7926473 )
1994
25
Hepatic coma as a presenting feature of constrictive pericarditis. ( 8438853 )
1993
26
Observation of lipid profile and lipoproteins in viral hepatitis and hepatic coma. ( 8294327 )
1993
27
[Rare case of endogenous hepatic coma in a patient during the course of viral hepatitis A with a good outcome after arterialization of portal blood]. ( 7817579 )
1993
28
Clinical effects of a sorbent suspension dialysis system in treatment of hepatic coma (the BioLogic-DT). ( 1521900 )
1992
29
Ammonia inhibits insulin stimulation of the Krebs cycle: further insight into mechanism of hepatic coma. ( 1944770 )
1991
30
Serum levels of short-chain fatty acids in cirrhosis and hepatic coma. ( 1959851 )
1991
31
Fractional excretion of beta-2-microglobulin in the urine of patients with normal or reduced renal function and hepatic coma. ( 2006396 )
1991
32
Transference of hepatic coma to normal rats from galactosamine treated donors by reverse plasma exchange. ( 2285809 )
1990
33
Pathophysiology of hepatic encephalopathy: studies in autopsied brain tissue from hepatic coma patients. ( 19256152 )
1990
34
Reduction of highly elevated plasma levels of gamma-aminobutyric acid does not reverse hepatic coma. ( 2613172 )
1989
35
Serum apoproteins A and B and the lecithin: cholesterol acyl transferase activities in liver cirrhosis and hepatic coma patients. ( 3233186 )
1988
36
Hepatic coma. ( 3065865 )
1988
37
Reversal of hepatic coma with flumazenil with improvement in visual evoked potentials. ( 2900422 )
1988
38
Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride. ( 3368028 )
1988
39
Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma. ( 3173602 )
1988
40
Lactulose detoxifies in vitro short-chain fatty acid production in colonic contents induced by blood: implications for hepatic coma. ( 3338644 )
1988
41
Postsynaptic gamma-aminobutyric acid receptors in hepatic coma following portacaval shunt and hepatic artery ligation in the rat. ( 2850456 )
1987
42
Hepatic coma: studies on the target organ. ( 2820830 )
1987
43
In hepatic coma, the problem comes from the colon, but will the answers come from there? ( 3611947 )
1987
44
Muscarinic, benzodiazepine, GABA, chloride channel and other binding sites in frontal cortex in hepatic coma in man. ( 2442800 )
1987
45
Brain cholecystokinin and vasoactive intestinal polypeptide: immunoreactivity in rabbits with hepatic coma. ( 3784782 )
1986
46
Hemodiafiltration treatment of deep hepatic coma by protein passing membrane: case report. ( 3789963 )
1986
47
Lack of evidence for impaired dopamine receptor function in experimental hepatic coma in the rabbit. ( 3010194 )
1986
48
Hepatic coma resulting from diaphragmatic rupture and hepatic herniation. ( 3729716 )
1986
49
Portal-systemic encephalopathy and hepatic coma. ( 2874273 )
1986
50
Adequate diet prevents hepatic coma in dogs with Eck fistulas. ( 3945890 )
1986

Variations for Hepatic Coma

Expression for Hepatic Coma

Search GEO for disease gene expression data for Hepatic Coma.

Pathways for Hepatic Coma

Pathways related to Hepatic Coma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 ACACA DBI
2 10.6 ALB F2
3
Show member pathways
9.88 DBI TSPO

GO Terms for Hepatic Coma

Cellular components related to Hepatic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.13 ALB DBI F2
2 extracellular exosome GO:0070062 9.1 ACACA ALB DBI F2 GPT TSPO

Biological processes related to Hepatic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of reactive oxygen species metabolic process GO:2000379 8.62 F2 TSPO

Molecular functions related to Hepatic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Hepatic Coma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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