MCID: HPT084
MIFTS: 12

Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Categories: Rare diseases, Liver diseases

Aliases & Classifications for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

MalaCards integrated aliases for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection:

Name: Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection 57
Hepatic Fibrosis Susceptibility Due to Schistosoma Mansoni Infection 57 13
Hepatic Fibrosis, Severe, Susceptibility to, Due to Schistosoma Mansoni Infection 57
Sm2 57

Classifications:



External Ids:

OMIM 57 604201

Summaries for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

OMIM : 57 Hepatointestinal schistosomiasis is caused by 2 species of helminths: Schistosoma japonicum, which is prevalent in Asia, and S. mansoni, which is prevalent in Africa and South America. Both worms develop in the host mesenteric system and lay eggs that trigger inflammation in the hepatic periportal space in which they are trapped. Worms live for years, and chronic liver inflammation and significant tissue destruction are therefore common in infected individuals. Tissue repair begins with deposition of extracellular matrix proteins (ECMPs) in the damaged tissues, which are later replaced by normal hepatocytes. In some individuals, ECMPs accumulate in the periportal space, forming fibrosis deposits that reduce blood flow and cause varicose veins. These individuals may die from the subsequent effects of hepatic fibrosis. About 5 to 10% of the 350 million infected individuals develop severe hepatic fibrosis. Development of hepatic fibrosis in schistosome-infected individuals is influenced by a locus on chromosome 6q23, designated SM2, which contains 2 major candidate genes: IFNGR1 (107470), which encodes a chain of the receptor for interferon-gamma (IFNG; 147570), and CTGF (121009), which encodes a profibrogenic molecule produced by hepatocytes (summary by Dessein et al., 2009). (604201)

MalaCards based summary : Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection, also known as hepatic fibrosis susceptibility due to schistosoma mansoni infection, is related to neuroblastoma and aging. An important gene associated with Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection is SM2 (Hepatic Fibrosis Susceptibility Due To Schistosoma Mansoni Infection). Affiliated tissues include liver.

Related Diseases for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Diseases in the Congenital Hepatic Fibrosis family:

Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Diseases related to Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroblastoma 9.9
2 aging 9.9
3 urinary tract obstruction 9.9

Symptoms & Phenotypes for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Clinical features from OMIM:

604201

Drugs & Therapeutics for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Search Clinical Trials , NIH Clinical Center for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Genetic Tests for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Anatomical Context for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

MalaCards organs/tissues related to Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection:

41
Liver

Publications for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Variations for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Expression for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Search GEO for disease gene expression data for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection.

Pathways for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

GO Terms for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

Sources for Hepatic Fibrosis, Severe Due to Schistosoma Mansoni Infection

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