MCID: HPT005
MIFTS: 32

Hepatic Flexure Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Flexure Cancer

MalaCards integrated aliases for Hepatic Flexure Cancer:

Name: Hepatic Flexure Cancer 12 15
Malignant Neoplasm of Hepatic Flexure of Colon 70
Malignant Neoplasm of Hepatic Flexure 12
Malignant Tumor of Hepatic Flexure 12
Carcinoma of Hepatic Flexure 70
Ca Hepatic Flexure - Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:260
ICD9CM 34 153.0
SNOMED-CT 67 93826009
ICD10 32 C18.3
UMLS 70 C0153433 C0589632

Summaries for Hepatic Flexure Cancer

MalaCards based summary : Hepatic Flexure Cancer, also known as malignant neoplasm of hepatic flexure of colon, is related to trachea carcinoma in situ and signet ring basal cell carcinoma. An important gene associated with Hepatic Flexure Cancer is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are MicroRNAs in cancer and Immune response Role of DAP12 receptors in NK cells. Affiliated tissues include colon and lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Hepatic Flexure Cancer

Diseases related to Hepatic Flexure Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 trachea carcinoma in situ 9.9 KRAS HRAS
2 signet ring basal cell carcinoma 9.9 KRAS HRAS
3 cobblestone retinal degeneration 9.9 KRAS HRAS
4 immature teratoma of ovary 9.9 KRAS HRAS
5 pancreatic signet ring cell adenocarcinoma 9.9 KRAS HRAS
6 signet ring cell adenocarcinoma 9.9 KRAS HRAS
7 descending colon cancer 9.9 KRAS HRAS
8 ampulla of vater benign neoplasm 9.9 KRAS HRAS
9 transverse colon cancer 9.9 KRAS HRAS
10 periampullary adenoma 9.9 KRAS HRAS
11 bone giant cell sarcoma 9.9 KRAS HRAS
12 acneiform dermatitis 9.9 KRAS HRAS
13 appendiceal neoplasm 9.9 KRAS HRAS
14 gallbladder benign neoplasm 9.9 KRAS HRAS
15 adenosquamous lung carcinoma 9.9 KRAS HRAS
16 appendix adenocarcinoma 9.9 KRAS HRAS
17 mucinous lung adenocarcinoma 9.9 KRAS HRAS
18 wolffian duct adenocarcinoma 9.9 KRAS HRAS
19 noonan syndrome-like disorder with loose anagen hair 1 9.9 KRAS HRAS
20 noonan syndrome-like disorder with loose anagen hair 9.9 KRAS HRAS
21 myh-associated polyposis 9.9 KRAS HRAS
22 ascending colon cancer 9.9 KRAS HRAS
23 biliary tract benign neoplasm 9.9 KRAS HRAS
24 ovarian mucinous neoplasm 9.9 KRAS HRAS
25 malignant exocrine pancreas neoplasm 9.9 KRAS HRAS
26 pancreatic acinar cell adenocarcinoma 9.9 KRAS HRAS
27 paronychia 9.9 KRAS HRAS
28 appendix disease 9.9 KRAS HRAS
29 bile duct cysts 9.9 KRAS HRAS
30 lung carcinoma in situ 9.9 KRAS HRAS
31 small intestine adenocarcinoma 9.9 KRAS HRAS
32 papillary adenoma 9.9 KRAS HRAS
33 ethmoid sinus adenocarcinoma 9.9 KRAS HRAS
34 appendix cancer 9.9 KRAS HRAS
35 duodenum adenocarcinoma 9.9 KRAS HRAS
36 core binding factor acute myeloid leukemia 9.9 KRAS HRAS
37 pulmonary adenocarcinoma in situ 9.9 KRAS HRAS
38 oculoectodermal syndrome 9.9 KRAS HRAS
39 large intestine adenocarcinoma 9.9 KRAS HRAS
40 nasal cavity adenocarcinoma 9.9 KRAS HRAS
41 eccrine papillary adenoma 9.9 KRAS HRAS
42 lung non-squamous non-small cell carcinoma 9.9 KRAS HRAS
43 myasthenic syndrome, congenital, 14 9.9 KRAS HRAS
44 rectosigmoid cancer 9.9 KRAS HRAS
45 female reproductive endometrioid cancer 9.9 KRAS HRAS
46 anus cancer 9.9 KRAS HRAS
47 duodenum cancer 9.9 KRAS HRAS
48 duodenum disease 9.9 KRAS HRAS
49 skin papilloma 9.9 KRAS HRAS
50 uterine body mixed cancer 9.9 KRAS HRAS

Comorbidity relations with Hepatic Flexure Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Colorectal Cancer Deficiency Anemia
Intestinal Obstruction Iron Deficiency Anemia
Paralytic Ileus Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Hepatic Flexure Cancer:



Diseases related to Hepatic Flexure Cancer

Symptoms & Phenotypes for Hepatic Flexure Cancer

GenomeRNAi Phenotypes related to Hepatic Flexure Cancer according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.98 KRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.98 KRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.98 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.98 KRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.98 KRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.98 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.98 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.98 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-196 9.98 KRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.98 KRAS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.98 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.98 KRAS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.98 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.98 HRAS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.98 KRAS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.98 KRAS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.98 KRAS
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.98 KRAS
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.98 HRAS
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-93 9.98 KRAS
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.98 HRAS
22 Decreased viability GR00055-A-1 9.44 HRAS KRAS
23 Decreased viability GR00055-A-2 9.44 HRAS KRAS
24 Decreased viability GR00055-A-3 9.44 KRAS
25 Decreased viability GR00106-A-0 9.44 KRAS
26 Decreased viability GR00221-A-1 9.44 HRAS KRAS
27 Decreased viability GR00221-A-2 9.44 HRAS KRAS
28 Decreased viability GR00221-A-3 9.44 HRAS
29 Decreased viability GR00301-A 9.44 KRAS
30 Decreased viability GR00381-A-1 9.44 KRAS
31 Decreased cell migration GR00055-A-3 8.85 HRAS

Drugs & Therapeutics for Hepatic Flexure Cancer

Search Clinical Trials , NIH Clinical Center for Hepatic Flexure Cancer

Genetic Tests for Hepatic Flexure Cancer

Anatomical Context for Hepatic Flexure Cancer

MalaCards organs/tissues related to Hepatic Flexure Cancer:

40
Colon, Lymph Node

Publications for Hepatic Flexure Cancer

Articles related to Hepatic Flexure Cancer:

# Title Authors PMID Year
1
Serum lipid profiles and risk of colorectal cancer: a prospective cohort study in the UK Biobank. 61
33139801 2021
2
A New Medial-to-Lateral Approach for Laparoscopic D3 Lymphadenectomy plus Complete Mesocolic Excision (D3 + CME) for Right-Sided Colon Cancer. 61
33135146 2020
3
Laparoscopic Complete Mesocolic Excision for Double Flexural Colon Cancers. 61
30927197 2019
4
Clinical Significance of Lymph Node Metastasis in the Mesentery of the Terminal Ileum in Patients With Right-sided Colon Tumors at Different Locations. 61
29664799 2018
5
Laparoscopic Radical Extended Right Hemicolectomy Using a Caudal-to-Cranial Approach. 61
27072997 2016
6
Laparoscopic extended right hemicolectomy for hepatic flexure cancer: a radical primary vascular approach with video vignette. 61
26467234 2016

Variations for Hepatic Flexure Cancer

Expression for Hepatic Flexure Cancer

Search GEO for disease gene expression data for Hepatic Flexure Cancer.

Pathways for Hepatic Flexure Cancer

Pathways related to Hepatic Flexure Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Super pathways Score Top Affiliating Genes
1 12.25 KRAS HRAS
2
Show member pathways
12.23 KRAS HRAS
3
Show member pathways
12.22 KRAS HRAS
4
Show member pathways
12.22 KRAS HRAS
5
Show member pathways
12.21 KRAS HRAS
6
Show member pathways
12.21 KRAS HRAS
7
Show member pathways
12.2 KRAS HRAS
8
Show member pathways
12.17 KRAS HRAS
9
Show member pathways
12.17 KRAS HRAS
10
Show member pathways
12.15 KRAS HRAS
11
Show member pathways
12.15 KRAS HRAS
12
Show member pathways
12.14 KRAS HRAS
13
Show member pathways
12.13 KRAS HRAS
14
Show member pathways
12.13 KRAS HRAS
15
Show member pathways
12.13 KRAS HRAS
16
Show member pathways
12.13 KRAS HRAS
17 12.08 KRAS HRAS
18
Show member pathways
12.08 KRAS HRAS
19
Show member pathways
12.07 KRAS HRAS
20 12.05 KRAS HRAS
21 12.04 KRAS HRAS
22
Show member pathways
12.04 KRAS HRAS
23
Show member pathways
12.04 KRAS HRAS
24
Show member pathways
12.03 KRAS HRAS
25
Show member pathways
12.01 KRAS HRAS
26 11.98 KRAS HRAS
27 11.97 KRAS HRAS
28
Show member pathways
11.97 KRAS HRAS
29
Show member pathways
11.95 KRAS HRAS
30
Show member pathways
11.94 KRAS HRAS
31 11.93 KRAS HRAS
32
Show member pathways
11.91 KRAS HRAS
33
Show member pathways
11.9 KRAS HRAS
34 11.9 KRAS HRAS
35
Show member pathways
11.88 KRAS HRAS
36
Show member pathways
11.87 KRAS HRAS
37
Show member pathways
11.87 KRAS HRAS
38 11.85 KRAS HRAS
39
Show member pathways
11.82 KRAS HRAS
40 11.82 KRAS HRAS
41 11.82 KRAS HRAS
42
Show member pathways
11.81 KRAS HRAS
43
Show member pathways
11.81 KRAS HRAS
44
Show member pathways
11.8 KRAS HRAS
45
Show member pathways
11.79 KRAS HRAS
46
Show member pathways
11.78 KRAS HRAS
47 11.76 KRAS HRAS
48
Show member pathways
11.75 KRAS HRAS
49 11.74 KRAS HRAS
50 11.73 KRAS HRAS

GO Terms for Hepatic Flexure Cancer

Biological processes related to Hepatic Flexure Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.46 KRAS HRAS
2 positive regulation of protein phosphorylation GO:0001934 9.43 KRAS HRAS
3 negative regulation of neuron apoptotic process GO:0043524 9.4 KRAS HRAS
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.37 KRAS HRAS
5 liver development GO:0001889 9.32 KRAS HRAS
6 Ras protein signal transduction GO:0007265 9.26 KRAS HRAS
7 positive regulation of MAP kinase activity GO:0043406 9.16 KRAS HRAS
8 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 KRAS HRAS
9 response to isolation stress GO:0035900 8.62 KRAS HRAS

Molecular functions related to Hepatic Flexure Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 KRAS HRAS

Sources for Hepatic Flexure Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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