MCID: HPT081
MIFTS: 30

Hepatic Infarction

Categories: Gastrointestinal diseases, Cardiovascular diseases, Endocrine diseases, Liver diseases

Aliases & Classifications for Hepatic Infarction

MalaCards integrated aliases for Hepatic Infarction:

Name: Hepatic Infarction 12 55 15 73
Infarct of Liver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13738
ICD10 33 K76.3
ICD9CM 35 573.4
SNOMED-CT 68 17890003
UMLS 73 C0151731

Summaries for Hepatic Infarction

MalaCards based summary : Hepatic Infarction, also known as infarct of liver, is related to catastrophic antiphospholipid syndrome and portal vein thrombosis. An important gene associated with Hepatic Infarction is APOH (Apolipoprotein H), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Hepatic Infarction

Diseases related to Hepatic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 catastrophic antiphospholipid syndrome 29.3 APOH F3 MTHFR
2 portal vein thrombosis 28.3 APOH F2 MTHFR SERPINC1
3 thrombophlebitis 27.9 APOH F2 MTHFR SERPINC1
4 antiphospholipid syndrome 27.4 APOH F2 F3 MTHFR SERPINC1
5 thrombosis 27.3 APOH F2 F3 MTHFR SERPINC1
6 hellp syndrome 27.1 APOH F2 F3 HADHA MTHFR SERPINC1
7 liver sarcoma 10.6 ADAM17 CA4
8 splenic infarction 10.6 APOH F2
9 papilledema 10.6 APOH F2
10 carotid artery occlusion 10.5 APOH CA4
11 hypochondriasis 10.5 F2 PHEX
12 orchitis 10.5 EDA GJB6
13 testicular disease 10.4 EDA GJB6
14 multiple personality disorder 10.3 CA4 OXT
15 parametritis 10.3 F2 OXT
16 hepatitis 10.3
17 mesenteric vascular occlusion 10.3 F2 MTHFR
18 ischemic neuropathy 10.2 F2 MTHFR
19 peliosis hepatis 10.2 F2 HADHA
20 cerebral falx meningioma 10.2 F2 F3
21 cryptogenic cirrhosis 10.1 F2 MTHFR
22 porencephaly 10.1 F2 MTHFR
23 qualitative platelet defect 10.1 F2 F3
24 von willebrand disease, type 1 10.1 F2 F3
25 femoral neuropathy 10.1 F2 F3
26 alcohol-related birth defect 10.1 F2 F3
27 livedoid vasculopathy 10.1 APOH F2 MTHFR
28 hantavirus pulmonary syndrome 10.1 F2 F3
29 scott syndrome 10.1 F2 FGD1
30 anterior cranial fossa meningioma 10.1 F2 F3
31 buerger disease 10.0 APOH F2 MTHFR
32 cerebral sinovenous thrombosis 10.0 APOH F2 F3
33 splenic disease 9.9 ADAM17 F2 F3
34 alpha-2-plasmin inhibitor deficiency 9.9 F2 SERPINC1
35 lemierre's syndrome 9.9 F3 MTHFR
36 hemophilia 9.8 F2 F3
37 anterior spinal artery syndrome 9.8 F2 SERPINC1
38 subendocardial myocardial infarction 9.8 F2 SERPINC1
39 esophageal varix 9.8 F2 SERPINC1
40 acute pancreatitis 9.7
41 pancreatitis 9.7
42 prothrombin deficiency, congenital 9.7 APOH F2 SERPINC1
43 heparin-induced thrombocytopenia 9.7 F3 SERPINC1
44 ischemic colitis 9.7 APOH F2 SERPINC1
45 sneddon syndrome 9.7 APOH F2 SERPINC1
46 post-thrombotic syndrome 9.7 F2 SERPINC1
47 intermittent claudication 9.7 APOH F2 SERPINC1
48 hypersplenism 9.7 F2 SERPINC1
49 endocarditis 9.6 APOH F2 SERPINC1
50 hepatocellular carcinoma 9.6

Comorbidity relations with Hepatic Infarction via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Hepatic Infarction:



Diseases related to Hepatic Infarction

Symptoms & Phenotypes for Hepatic Infarction

MGI Mouse Phenotypes related to Hepatic Infarction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ADAM17 APOH CA4 F2 F3 GJB6
2 mortality/aging MP:0010768 9.32 ADAM17 APOH CA4 F2 F3 HADHA

Drugs & Therapeutics for Hepatic Infarction

Search Clinical Trials , NIH Clinical Center for Hepatic Infarction

Genetic Tests for Hepatic Infarction

Anatomical Context for Hepatic Infarction

MalaCards organs/tissues related to Hepatic Infarction:

41
Liver

Publications for Hepatic Infarction

Articles related to Hepatic Infarction:

(show all 35)
# Title Authors Year
1
Hepatic infarction induced by HELLP syndrome: a case report and review of the literature. ( 29848304 )
2018
2
Hepatic infarction and acute pancreatitis: a case report and review of the literature. ( 29594198 )
2018
3
Acute mesenteric ischemia and hepatic infarction after treatment of ectopic Cushing's syndrome. ( 28480039 )
2017
4
Massive Hepatic Infarction Caused by HELLP Syndrome. ( 28670595 )
2017
5
Hepatic infarction from portal vein thrombosis: A fatal consequence of acute pancreatitis. ( 28421699 )
2017
6
Hepatic Infarction following splenectomy. ( 28109532 )
2017
7
Hepatic infarction in a pregnant woman with antiphospholipid syndrome and triple antibody positivity: A case report focusing on catastrophic antiphospholipid syndrome. ( 27668204 )
2016
8
Spontaneous Hepatic Infarction in a Patient with Gallbladder Cancer. ( 27462232 )
2016
9
Fulminant liver failure resulting from massive hepatic infarction associated with hemolysis, elevated liver enzymes, and low platelets syndrome. ( 27353746 )
2016
10
Hepatic Infarction Caused by Portal Vein Thrombophlebitis Misdiagnosed as Infiltrative Hepatic Malignancy with Neoplastic Thrombus. ( 27646586 )
2016
11
Recurrent gastrointestinal bleeding and hepatic infarction after liver biopsy. ( 24587666 )
2014
12
Hepatic infarction complicated with acute pancreatitis precisely diagnosed with gadoxetate disodium-enhanced magnetic resonance imaging. ( 25274233 )
2014
13
Microcirculation Approach in HELLP Syndrome Complicated by Posterior Reversible Encephalopathy Syndrome and Massive Hepatic Infarction. ( 25485160 )
2014
14
Hepatic infarction caused by vascular migration of fiducial marker previously placed under endosonographic guidance to assist radiotherapy. ( 25502251 )
2014
15
HELLP syndrome with postpartum hepatic infarction and subcapsular bleeding. ( 22515349 )
2012
16
Extensive hepatic infarction in severe preeclampsia as part of the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): evolution of CT findings and successful treatment with plasma exchange therapy. ( 23040928 )
2012
17
MRI diagnosis and follow-up of hepatic infarction in a patient with antiphospholipid syndrome in early pregnancy. ( 20411270 )
2011
18
Failure to thrive: an unexpected finding after Whipple's resection. Image 1: Extensive hepatic infarction: an extremely rare complication of Whipple's resection. ( 21524654 )
2011
19
Lethal hepatic infarction following plasma exchange in living donor liver transplant patients. ( 21382102 )
2011
20
Liver failure after an uncovered TIPS procedure associated with hepatic infarction. ( 21160990 )
2010
21
Eleven cases of postoperative hepatic infarction following pancreato-biliary surgery. ( 19937194 )
2010
22
Acute aortic dissection causing gastroduodenal and hepatic infarction. ( 19370528 )
2009
23
Massive hepatic infarction after pure ethanol injection and radiofrequency ablation therapy for hepatocellular carcinoma: a case report. ( 19419922 )
2009
24
Late acute celiac and hepatic artery thrombosis with portal vein thrombosis resulting in hepatic infarction 12 years post orthotopic liver transplantation. ( 20009144 )
2009
25
Hepatic infarction after radiofrequency ablation of hepatocellular carcinoma with an internally cooled electrode. ( 17804775 )
2007
26
Hepatic infarction during pregnancy in catastrophic antiphospholipid syndrome. ( 17845701 )
2007
27
Favorable resolution of hepatic infarctions in transplanted liver after portal vein thrombosis treated by surgical thrombectomy: a case report. ( 17112919 )
2006
28
Hepatic infarctions during pregnancy are associated with the antiphospholipid syndrome and in addition with complete or incomplete HELLP syndrome. ( 12911590 )
2003
29
CT and MRI findings of congestive hepatic infarction caused by tumor thrombus of HCC in the hepatic vein: histopathological correlations. ( 10510907 )
1999
30
Hepatic infarction in preeclampsia as part of the HELLP syndrome: CT appearance. ( 10525815 )
1999
31
Extensive hepatic infarction caused by thrombosis of right portal vein branches and arterial vasospasm in HELLP syndrome associated with homozygous factor V Leiden. ( 9517665 )
1998
32
Hepatic infarction in a hemodialysis patient with systemic lupus erythematosus. ( 7485132 )
1995
33
Hepatic infarction and nodular regenerative hyperplasia of the liver with associated anticardiolipin antibodies in a young woman. ( 8071516 )
1994
34
Hepatic infarction in a pregnant patient with the 'primary' antiphospholipid syndrome. ( 8268978 )
1993
35
Hepatic infarction in preeclampsia. ( 2243977 )
1990

Variations for Hepatic Infarction

Expression for Hepatic Infarction

Search GEO for disease gene expression data for Hepatic Infarction.

Pathways for Hepatic Infarction

GO Terms for Hepatic Infarction

Biological processes related to Hepatic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 one-carbon metabolic process GO:0006730 9.4 CA4 MTHFR
2 response to electrical stimulus GO:0051602 9.37 GJB6 OXT
3 blood coagulation, intrinsic pathway GO:0007597 9.32 APOH F2
4 positive regulation of blood coagulation GO:0030194 9.26 APOH F2
5 negative regulation of fibrinolysis GO:0051918 9.16 APOH F2
6 hemostasis GO:0007599 9.13 F2 F3 SERPINC1
7 regulation of blood coagulation GO:0030193 8.8 APOH F2 SERPINC1

Molecular functions related to Hepatic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Hepatic Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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