MCID: HPT020
MIFTS: 36

Hepatic Vascular Disease

Categories: Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hepatic Vascular Disease

MalaCards integrated aliases for Hepatic Vascular Disease:

Name: Hepatic Vascular Disease 12 15
Vascular Disorder of Liver 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:272
NCIt 50 C35442
SNOMED-CT 68 235878005
UMLS 73 C0400923

Summaries for Hepatic Vascular Disease

Disease Ontology : 12 A vascular disease that is located in the liver.

MalaCards based summary : Hepatic Vascular Disease, also known as vascular disorder of liver, is related to hepatic veno-occlusive disease and portal hypertension. An important gene associated with Hepatic Vascular Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Immune response IL-23 signaling pathway. Affiliated tissues include the liver, liver and myeloid, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Hepatic Vascular Disease

Diseases related to Hepatic Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 hepatic veno-occlusive disease 29.7 F3 PLG SERPINC1 SERPINE1 SP110
2 portal hypertension 28.1 ALB EDN1 F2 JAK2 NOS3 SST
3 vascular disease 25.3 ALB EDN1 F2 F3 MTHFR NOS3
4 antipyrine metabolism 11.0 ALB F2
5 non-a-e hepatitis 11.0 ALB F2
6 chronic thromboembolic pulmonary hypertension 10.9 EDN1 F2
7 abdominal tuberculosis 10.9 ALB F2
8 kwashiorkor 10.7 ALB F2
9 prothrombin deficiency, congenital 10.7 F2 SERPINC1
10 hepatic tuberculosis 10.7 ALB F2
11 benign essential hypertension 10.7 ALB REN
12 coronary artery vasospasm 10.7 EDN1 NOS3
13 kidney papillary necrosis 10.7 ALB REN
14 burns 10.7 ALB SERPINC1
15 hypersplenism 10.7 ALB F2 SERPINC1
16 dysfibrinogenemia 10.7 ALB F2 SERPINC1
17 renal artery obstruction 10.7 REN SERPINC1
18 hepatopulmonary syndrome 10.7 ALB EDN1 NOS3
19 perinephritis 10.6 EDN1 REN
20 alcoholic liver cirrhosis 10.6 AFP ALB F2
21 endocarditis 10.6 ALB F2 SERPINC1
22 cerebral sinovenous thrombosis 10.6 F2 F3
23 chronic mountain sickness 10.6 EDN1 NOS3 SST
24 viral hepatitis 10.6 AFP ALB F2
25 hepatoid adenocarcinoma 10.6 AFP ALB
26 ischemic colitis 10.6 F2 JAK2 SERPINC1
27 renal artery disease 10.6 NOS3 REN
28 postural hypotension 10.6 REN SST
29 alpha-2-plasmin inhibitor deficiency 10.6 F2 PLG SERPINC1
30 qualitative platelet defect 10.6 F2 F3
31 anterior spinal artery syndrome 10.6 F2 PLG SERPINC1
32 endometrial small cell carcinoma 10.5 AFP F2
33 renal hypertension 10.5 ALB EDN1 REN
34 liver sarcoma 10.5 ADAM17 AFP
35 heparin-induced thrombocytopenia 10.5 F3 SERPINC1
36 conjugate gaze palsy 10.5 F3 PLG
37 von willebrand disease, type 1 10.5 F2 F3
38 renovascular hypertension 10.5 EDN1 NOS3 REN
39 analbuminemia 10.5 ALB F2 F3
40 urinary system disease 10.5 ALB EDN1 REN
41 gastrointestinal system cancer 10.4 ADAM17 AFP ALB F2
42 sleep apnea 10.4 EDN1 NOS3 REN
43 dengue hemorrhagic fever 10.4 ALB F2 F3
44 sagittal sinus thrombosis 10.4 F2 F3 SERPINC1
45 purpura fulminans 10.4 F2 F3 SERPINC1
46 inherited blood coagulation disease 10.4 F2 F3 SERPINC1
47 prothrombin deficiency 10.4 F2 F3 SERPINC1
48 fibrinolytic defect 10.4 SERPINC1 SERPINE1
49 peripheral vertigo 10.4 F2 F3 SERPINC1
50 yellow nail syndrome 10.4 ALB SST

Graphical network of the top 20 diseases related to Hepatic Vascular Disease:



Diseases related to Hepatic Vascular Disease

Symptoms & Phenotypes for Hepatic Vascular Disease

MGI Mouse Phenotypes related to Hepatic Vascular Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 SST REN NOS3 SERPINC1 SERPINE1 PLG
2 growth/size/body region MP:0005378 10.22 SST REN MTHFR NOS3 SERPINE1 PLG
3 mortality/aging MP:0010768 10.21 SST REN NOS3 SERPINC1 SERPINE1 PLG
4 cardiovascular system MP:0005385 10.16 SERPINE1 PLG REN NOS3 SERPINC1 EDN1
5 immune system MP:0005387 10.13 PLG SST REN NOS3 SERPINC1 SERPINE1
6 digestive/alimentary MP:0005381 10.04 PLG SST NOS3 EDN1 ADAM17 F2
7 liver/biliary system MP:0005370 10.01 NOS3 SERPINC1 SERPINE1 PLG AFP ALB
8 nervous system MP:0003631 9.96 PLG MTHFR REN SERPINC1 NOS3 EDN1
9 normal MP:0002873 9.81 SST REN NOS3 EDN1 ADAM17 F2
10 neoplasm MP:0002006 9.8 SERPINE1 PLG JAK2 AFP F3 ALB
11 renal/urinary system MP:0005367 9.5 PLG REN NOS3 SERPINC1 SERPINE1 EDN1
12 reproductive system MP:0005389 9.28 REN MTHFR NOS3 SERPINC1 PLG ADAM17

Drugs & Therapeutics for Hepatic Vascular Disease

Search Clinical Trials , NIH Clinical Center for Hepatic Vascular Disease

Genetic Tests for Hepatic Vascular Disease

Anatomical Context for Hepatic Vascular Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatic Vascular Disease:

19
The Liver

MalaCards organs/tissues related to Hepatic Vascular Disease:

41
Liver, Myeloid, Kidney

Publications for Hepatic Vascular Disease

Articles related to Hepatic Vascular Disease:

# Title Authors Year
1
A Comprehensive Approach to Hepatic Vascular Disease. ( 28430541 )
2017
2
Hepatic vascular disease and portal hypertension in polycythemia vera and agnogenic myeloid metaplasia: a clinicopathological study of 145 patients examined at autopsy. ( 2227815 )
1990
3
Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature. ( 3114679 )
1987

Variations for Hepatic Vascular Disease

Expression for Hepatic Vascular Disease

Search GEO for disease gene expression data for Hepatic Vascular Disease.

Pathways for Hepatic Vascular Disease

Pathways related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 ALB F2 F3 JAK2 NOS3 PLG
2
Show member pathways
12.31 F2 JAK2 NOS3 PLG
3
Show member pathways
11.99 ALB F2 MTHFR PLG SERPINE1
4 11.76 F3 PLG SERPINE1
5
Show member pathways
11.76 F2 F3 PLG SERPINC1 SERPINE1
6 11.63 EDN1 NOS3 SERPINE1
7 11.53 F3 NOS3 REN
8 11.5 F2 F3 PLG SERPINC1 SERPINE1
9 11.19 AFP ALB F2
10 11.02 EDN1 F3 JAK2 NOS3 SERPINE1
11 10.55 PLG SERPINE1

GO Terms for Hepatic Vascular Disease

Cellular components related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AFP ALB EDN1 F2 F3 PLG
2 endoplasmic reticulum lumen GO:0005788 9.62 AFP ALB F2 SERPINC1
3 blood microparticle GO:0072562 9.46 ALB F2 PLG SERPINC1
4 platelet alpha granule lumen GO:0031093 9.43 ALB PLG SERPINE1
5 extracellular space GO:0005615 9.36 AFP ALB EDN1 F2 F3 PLG

Biological processes related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.91 EDN1 F2 SERPINE1 SST UTS2
2 negative regulation of cell proliferation GO:0008285 9.89 CD33 JAK2 NOS3 PLG SST
3 positive regulation of cell migration GO:0030335 9.83 ADAM17 EDN1 F3 JAK2
4 response to drug GO:0042493 9.83 ADAM17 EDN1 MTHFR REN SST
5 platelet degranulation GO:0002576 9.77 ALB PLG SERPINE1
6 cellular protein metabolic process GO:0044267 9.77 AFP ALB F2 PLG SERPINC1
7 blood coagulation GO:0007596 9.72 F2 F3 JAK2 PLG SERPINC1
8 response to lipopolysaccharide GO:0032496 9.65 ADAM17 EDN1 JAK2 NOS3 REN
9 response to amino acid GO:0043200 9.63 EDN1 MTHFR SST
10 regulation of blood vessel size GO:0050880 9.58 EDN1 NOS3
11 negative regulation of blood coagulation GO:0030195 9.58 EDN1 SERPINE1
12 fibrinolysis GO:0042730 9.58 F2 PLG SERPINE1
13 positive regulation of blood coagulation GO:0030194 9.57 F2 SERPINE1
14 regulation of blood coagulation GO:0030193 9.56 F2 SERPINC1
15 negative regulation of platelet activation GO:0010544 9.55 F2 NOS3
16 ovulation from ovarian follicle GO:0001542 9.54 AFP NOS3
17 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.48 EDN1 NOS3
18 regulation of blood pressure GO:0008217 9.46 EDN1 NOS3 REN UTS2
19 hemostasis GO:0007599 9.26 F2 F3 PLG SERPINC1
20 negative regulation of fibrinolysis GO:0051918 8.8 F2 PLG SERPINE1

Molecular functions related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 EDN1 SST UTS2
2 signaling receptor binding GO:0005102 9.17 EDN1 F2 JAK2 PLG REN SERPINE1
3 protease binding GO:0002020 9.13 F3 SERPINC1 SERPINE1

Sources for Hepatic Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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