MCID: HPT020
MIFTS: 34

Hepatic Vascular Disease

Categories: Cardiovascular diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatic Vascular Disease

MalaCards integrated aliases for Hepatic Vascular Disease:

Name: Hepatic Vascular Disease 12 15
Vascular Disorder of Liver 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:272
NCIt 49 C35442
SNOMED-CT 67 235878005
UMLS 71 C0400923

Summaries for Hepatic Vascular Disease

Disease Ontology : 12 A vascular disease that is located in the liver.

MalaCards based summary : Hepatic Vascular Disease, also known as vascular disorder of liver, is related to hepatic veno-occlusive disease and portal vein thrombosis. An important gene associated with Hepatic Vascular Disease is ALB (Albumin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Relaxin signaling pathway. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and myeloid, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Hepatic Vascular Disease

Diseases in the Hepatic Vascular Disease family:

Rare Vascular Liver Disease

Diseases related to Hepatic Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 392)
# Related Disease Score Top Affiliating Genes
1 hepatic veno-occlusive disease 33.0 VEGFA THPO SERPINC1 F3
2 portal vein thrombosis 32.9 SERPINC1 REN JAK2 F2 AFP
3 budd-chiari syndrome 30.7 SERPINC1 JAK2 F3 F2
4 hepatoportal sclerosis 30.6 GPT F2
5 peliosis hepatis 30.5 VEGFA GPT AFP
6 thrombophlebitis 30.4 SERPINC1 F3 F2 ALB
7 hepatopulmonary syndrome 30.3 VEGFA NOS3 EDN1 ALB
8 varicose veins 30.2 VEGFA SERPINC1 F2
9 vascular disease 30.2 VEGFA SERPINC1 REN NOS3 MIR214 MIR199A1
10 polycythemia 29.8 VEGFA THPO JAK2
11 portal hypertension 29.8 VEGFA THPO SST NOS3 JAK2 GPT
12 blood coagulation disease 29.7 VEGFA THPO SERPINC1 JAK2 GPT F3
13 esophageal varix 29.4 SST SERPINC1 GPT GGTLC3 GGT2 GGT1
14 vein disease 28.9 VEGFA SST SERPINC1 JAK2 GPT GGTLC3
15 non-a-e hepatitis 10.7 F2 ALB
16 antipyrine metabolism 10.7 F2 ALB
17 dipetalonemiasis 10.7 GPT ALB
18 cholecystitis 10.7 GPT F2 ALB
19 achenbach syndrome 10.7 F3 F2
20 pylorus cancer 10.7 SST ALB
21 splenic abscess 10.7 GPT F2 ALB
22 acalculous cholecystitis 10.7 GPT F2 ALB
23 spinal cord infarction 10.7 SERPINC1 F2
24 endocarditis 10.7 SERPINC1 F2 ALB
25 infantile liver failure syndrome 1 10.7 GPT F2 ALB
26 heterophyiasis 10.7 GPT ALB
27 abdominal tuberculosis 10.7 GPT F2 ALB
28 paralytic ileus 10.7 GPT F2 ALB
29 papillary adenofibroma 10.7 F3 F2 AFP
30 pyuria 10.7 GPT F2 ALB
31 preeclampsia/eclampsia 1 10.7 SERPINC1 NOS3
32 kwashiorkor 10.7 GPT F2 ALB
33 emphysematous cholecystitis 10.7 GPT F3 F2
34 sudden sensorineural hearing loss 10.7 SERPINC1 F2
35 epidural abscess 10.7 F3 F2 ALB
36 yellow nail syndrome 10.7 SST CCR6 ALB
37 thymus sarcomatoid carcinoma 10.7 ALB AFP
38 synovial angioma 10.7 F3 F2
39 klatskin's tumor 10.7 GPT ALB AFP
40 critical illness polyneuropathy 10.7 GPT F3 ALB
41 blue toe syndrome 10.7 SERPINC1 F3 F2
42 lateral sinus thrombosis 10.7 SERPINC1 F3 F2
43 dic in newborn 10.7 SERPINC1 F3 F2
44 mediastinitis 10.7 F3 F2 ALB
45 hematocele of tunica vaginalis testis 10.7 F2 AFP
46 waterhouse-friderichsen syndrome 10.7 SERPINC1 F3 F2
47 cavernous sinus thrombosis 10.7 SERPINC1 F3 F2
48 lemierre's syndrome 10.7 SERPINC1 F3 F2
49 acute liver failure 10.7 GPT F2 ALB
50 renal pelvis squamous cell carcinoma 10.7 F3 F2

Graphical network of the top 20 diseases related to Hepatic Vascular Disease:



Diseases related to Hepatic Vascular Disease

Symptoms & Phenotypes for Hepatic Vascular Disease

MGI Mouse Phenotypes related to Hepatic Vascular Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 AFP ALB CCR6 EDN1 F2 F3
2 cardiovascular system MP:0005385 9.96 ALB CCR6 EDN1 F2 F3 JAK2
3 immune system MP:0005387 9.73 ALB CCR6 F2 F3 GGT1 JAK2
4 normal MP:0002873 9.32 ALB CCR6 EDN1 F2 F3 JAK2

Drugs & Therapeutics for Hepatic Vascular Disease

Drugs for Hepatic Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vascular Liver Disease Evaluation, Follow Up and Non-Invasive Diagnostics Program Recruiting NCT03717792

Search NIH Clinical Center for Hepatic Vascular Disease

Genetic Tests for Hepatic Vascular Disease

Anatomical Context for Hepatic Vascular Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatic Vascular Disease:

19
Liver

MalaCards organs/tissues related to Hepatic Vascular Disease:

40
Liver, Kidney, Myeloid

Publications for Hepatic Vascular Disease

Articles related to Hepatic Vascular Disease:

# Title Authors PMID Year
1
Nodular regenerative hyperplasia - An under-recognized vascular disorder of liver. 61
32164988 2020
2
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis: A case report. 61
31606353 2019
3
Expert consensus on the clinical management of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome. 61
30669184 2019
4
A Comprehensive Approach to Hepatic Vascular Disease. 61
28430541 2017
5
Extrahepatic portal vein obstruction and portal vein thrombosis in special situations: Need for a new classification. 61
26021771 2015
6
Magnetic resonance (MR) imaging and MR angiography for evaluation and follow-up of hepatic artery banding in patients with hepatic involvement of hereditary hemorrhagic telangiectasia. 61
16465571 2006
7
Hepatic vascular disease and portal hypertension in polycythemia vera and agnogenic myeloid metaplasia: a clinicopathological study of 145 patients examined at autopsy. 61
2227815 1990
8
Fatal hepatic vascular toxicity of DTIC. Is it really a rare event? 61
3359400 1988
9
Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature. 61
3114679 1987

Variations for Hepatic Vascular Disease

Expression for Hepatic Vascular Disease

Search GEO for disease gene expression data for Hepatic Vascular Disease.

Pathways for Hepatic Vascular Disease

GO Terms for Hepatic Vascular Disease

Cellular components related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 VEGFA THPO SST SERPINC1 REN F3
2 extracellular space GO:0005615 9.44 VEGFA THPO SST SERPINC1 REN MIR199A1

Biological processes related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.89 VEGFA JAK2 F3 EDN1
2 cellular protein metabolic process GO:0044267 9.88 SERPINC1 F2 ALB AFP
3 blood coagulation GO:0007596 9.81 SERPINC1 JAK2 F3 F2
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.71 MIR199A1 JAK2 EDN1 CCR6
5 regulation of blood pressure GO:0008217 9.7 REN NOS3 EDN1
6 positive regulation of endothelial cell migration GO:0010595 9.67 VEGFA MIR199A1 EDN1
7 positive regulation of angiogenesis GO:0045766 9.67 VEGFA NOS3 MIR199A1 F3
8 hemostasis GO:0007599 9.65 SERPINC1 F3 F2
9 regulation of blood coagulation GO:0030193 9.61 SERPINC1 F2
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.61 MIR214 JAK2 EDN1
11 positive regulation of positive chemotaxis GO:0050927 9.6 VEGFA F3
12 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.58 MIR214 MIR199A1
13 positive regulation of receptor biosynthetic process GO:0010870 9.57 JAK2 EDN1
14 negative regulation of platelet activation GO:0010544 9.56 NOS3 F2
15 regulation of immune system process GO:0002682 9.55 GGT2 GGT1
16 ovulation from ovarian follicle GO:0001542 9.54 NOS3 AFP
17 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.46 NOS3 EDN1
18 response to tumor necrosis factor GO:0034612 9.43 JAK2 GGT2 GGT1
19 glutathione catabolic process GO:0006751 9.33 GGTLC3 GGT2 GGT1
20 peptide modification GO:0031179 9.32 GGT2 GGT1
21 leukotriene D4 biosynthetic process GO:1901750 9.13 GGTLC3 GGT2 GGT1
22 response to lipopolysaccharide GO:0032496 9.1 REN NOS3 JAK2 GGT2 GGT1 EDN1

Molecular functions related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 THPO REN JAK2 F2 EDN1
2 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
3 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Hepatic Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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