MCID: HPT020
MIFTS: 38

Hepatic Vascular Disease

Categories: Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hepatic Vascular Disease

MalaCards integrated aliases for Hepatic Vascular Disease:

Name: Hepatic Vascular Disease 12 15
Vascular Disorder of Liver 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:272
NCIt 51 C35442
UMLS 74 C0400923

Summaries for Hepatic Vascular Disease

Disease Ontology : 12 A vascular disease that is located in the liver.

MalaCards based summary : Hepatic Vascular Disease, also known as vascular disorder of liver, is related to hepatic veno-occlusive disease and portal hypertension. An important gene associated with Hepatic Vascular Disease is ALB (Albumin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Immune response IL-23 signaling pathway. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and myeloid, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Hepatic Vascular Disease

Diseases related to Hepatic Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 hepatic veno-occlusive disease 30.4 F3 PLG SERPINC1 SERPINE1 SP110
2 portal hypertension 28.4 ALB DGUOK EDN1 F2 GPT JAK2
3 vascular disease 28.0 ALB EDN1 F2 F3 NOS3 PLG
4 hepatoid adenocarcinoma 10.5 AFP ALB
5 endometrial small cell carcinoma 10.5 AFP F2
6 burns 10.5 ALB SERPINC1
7 prothrombin deficiency, congenital 10.5 F2 SERPINC1
8 liver sarcoma 10.5 ADAM17 AFP
9 yellow nail syndrome 10.5 ALB SST
10 antipyrine metabolism 10.5 ALB F2
11 non-a-e hepatitis 10.5 ALB F2
12 orthostatic proteinuria 10.4 ALB REN
13 epstein-barr virus hepatitis 10.4 ALB F2
14 hepatoportal sclerosis 10.4 F2 GPT
15 spinal cord infarction 10.4 F2 SERPINC1
16 raynaud disease 10.4 EDN1 VWF
17 endocarditis 10.3 ALB F2 SERPINC1
18 hepatic tuberculosis 10.3 ALB F2 GPT
19 kwashiorkor 10.3 ALB F2 GPT
20 hepatic coma 10.3 ALB F2 GPT
21 infantile liver failure syndrome 1 10.3 ALB F2 GPT
22 hyperglycemia 10.3 ALB NOS3 SST
23 hypersplenism 10.3 ALB F2 SERPINC1
24 biliary tract disease 10.3 AFP ALB F2
25 dysfibrinogenemia 10.3 ALB F2 SERPINC1
26 abdominal tuberculosis 10.3 ALB F2
27 choledocholithiasis 10.3 ALB F2 GPT
28 alcoholic liver cirrhosis 10.3 AFP ALB F2
29 acute liver failure 10.3 ALB F2 GPT
30 hepatitis e 10.3 ALB F2 GPT
31 cholecystitis 10.3 ALB F2 GPT
32 bilirubin metabolic disorder 10.3 ALB F2 GPT
33 chronic mountain sickness 10.3 EDN1 NOS3 SST
34 acquired von willebrand syndrome 10.3 JAK2 VWF
35 angina pectoris 10.3 EDN1 NOS3 SERPINC1
36 benign essential hypertension 10.3 ALB REN
37 hepatic encephalopathy 10.3 ALB F2 GPT
38 kidney papillary necrosis 10.3 ALB REN
39 alcoholic hepatitis 10.3 ALB F2 GPT
40 wilson disease 10.3 ALB F2 GPT
41 renovascular hypertension 10.3 EDN1 NOS3 REN
42 alpha-2-plasmin inhibitor deficiency 10.3 F2 PLG SERPINC1
43 renal artery obstruction 10.3 REN SERPINC1
44 intracranial embolism 10.2 F2 PLG SERPINC1
45 cholangitis 10.2 ALB F2 GPT
46 renal hypertension 10.2 ALB EDN1 REN
47 retinal vascular occlusion 10.2 F2 PLG SERPINC1
48 anterior spinal artery syndrome 10.2 F2 PLG SERPINC1
49 gastrointestinal system cancer 10.2 ADAM17 AFP ALB F2
50 bile duct disease 10.2 AFP ALB F2 GPT

Graphical network of the top 20 diseases related to Hepatic Vascular Disease:



Diseases related to Hepatic Vascular Disease

Symptoms & Phenotypes for Hepatic Vascular Disease

MGI Mouse Phenotypes related to Hepatic Vascular Disease:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 ADAM17 AFP ALB EDN1 F2 F3
2 cardiovascular system MP:0005385 10.21 ADAM17 EDN1 F2 F3 NOS3 PLG
3 mortality/aging MP:0010768 10.21 ADAM17 AFP ALB EDN1 F2 F3
4 hematopoietic system MP:0005397 10.18 ADAM17 F2 F3 JAK2 NOS3 PLG
5 immune system MP:0005387 10.17 ADAM17 F2 F3 JAK2 NOS3 PLG
6 digestive/alimentary MP:0005381 10.1 ADAM17 ALB EDN1 F2 NOS3 PLG
7 nervous system MP:0003631 9.96 ADAM17 EDN1 F2 F3 NOS3 PLG
8 liver/biliary system MP:0005370 9.95 AFP ALB JAK2 NOS3 PLG SERPINC1
9 normal MP:0002873 9.81 ADAM17 ALB EDN1 F2 F3 JAK2
10 neoplasm MP:0002006 9.8 AFP ALB F3 JAK2 PLG SERPINE1
11 renal/urinary system MP:0005367 9.5 ALB EDN1 NOS3 PLG REN SERPINC1
12 reproductive system MP:0005389 9.23 ADAM17 AFP F2 JAK2 NOS3 PLG

Drugs & Therapeutics for Hepatic Vascular Disease

Drugs for Hepatic Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vascular Liver Disease Evaluation, Follow Up and Non-Invasive Diagnostics Program Recruiting NCT03717792

Search NIH Clinical Center for Hepatic Vascular Disease

Genetic Tests for Hepatic Vascular Disease

Anatomical Context for Hepatic Vascular Disease

MalaCards organs/tissues related to Hepatic Vascular Disease:

42
Liver, Kidney, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatic Vascular Disease:

20
The Liver

Publications for Hepatic Vascular Disease

Articles related to Hepatic Vascular Disease:

# Title Authors Year
1
A Comprehensive Approach to Hepatic Vascular Disease. ( 28430541 )
2017
2
Hepatic vascular disease and portal hypertension in polycythemia vera and agnogenic myeloid metaplasia: a clinicopathological study of 145 patients examined at autopsy. ( 2227815 )
1990
3
Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature. ( 3114679 )
1987

Variations for Hepatic Vascular Disease

Expression for Hepatic Vascular Disease

Search GEO for disease gene expression data for Hepatic Vascular Disease.

Pathways for Hepatic Vascular Disease

Pathways related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 ALB F2 F3 JAK2 NOS3 PLG
2
Show member pathways
12.31 F2 JAK2 NOS3 PLG
3
Show member pathways
12.04 ALB F2 PLG SERPINE1
4 11.76 F3 PLG SERPINE1
5 11.63 EDN1 NOS3 SERPINE1
6
Show member pathways
11.63 F2 F3 PLG SERPINC1 SERPINE1 VWF
7 11.57 F3 NOS3 REN VWF
8 11.55 EDN1 F3 JAK2 NOS3 SERPINE1
9 11.24 F2 F3 PLG SERPINC1 SERPINE1 VWF
10 11.19 AFP ALB F2
11 10.55 PLG SERPINE1

GO Terms for Hepatic Vascular Disease

Cellular components related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.71 AFP ALB F2 SERPINC1
2 extracellular region GO:0005576 9.7 AFP ALB EDN1 F2 F3 PLG
3 collagen-containing extracellular matrix GO:0062023 9.65 F3 PLG SERPINC1 SERPINE1 VWF
4 blood microparticle GO:0072562 9.62 ALB F2 PLG SERPINC1
5 platelet alpha granule lumen GO:0031093 9.46 ALB PLG SERPINE1 VWF
6 Weibel-Palade body GO:0033093 9.37 EDN1 VWF
7 extracellular space GO:0005615 9.36 AFP ALB EDN1 F2 F3 GPT

Biological processes related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.87 ADAM17 EDN1 REN SST
2 negative regulation of cell proliferation GO:0008285 9.85 CD33 JAK2 NOS3 PLG SST
3 positive regulation of cell migration GO:0030335 9.83 ADAM17 EDN1 F3 JAK2
4 cellular protein metabolic process GO:0044267 9.72 AFP ALB F2 PLG SERPINC1
5 platelet degranulation GO:0002576 9.71 ALB PLG SERPINE1 VWF
6 regulation of blood pressure GO:0008217 9.65 EDN1 NOS3 REN
7 response to lipopolysaccharide GO:0032496 9.65 ADAM17 EDN1 JAK2 NOS3 REN
8 regulation of blood vessel size GO:0050880 9.58 EDN1 NOS3
9 blood coagulation, intrinsic pathway GO:0007597 9.58 F2 VWF
10 negative regulation of blood coagulation GO:0030195 9.56 EDN1 SERPINE1
11 positive regulation of blood coagulation GO:0030194 9.55 F2 SERPINE1
12 regulation of blood coagulation GO:0030193 9.54 F2 SERPINC1
13 fibrinolysis GO:0042730 9.54 F2 PLG SERPINE1
14 negative regulation of platelet activation GO:0010544 9.51 F2 NOS3
15 ovulation from ovarian follicle GO:0001542 9.49 AFP NOS3
16 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.43 EDN1 NOS3
17 blood coagulation GO:0007596 9.43 F2 F3 JAK2 PLG SERPINC1 VWF
18 negative regulation of fibrinolysis GO:0051918 9.33 F2 PLG SERPINE1
19 hemostasis GO:0007599 9.02 F2 F3 PLG SERPINC1 VWF

Molecular functions related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.43 ALB PLG VWF
2 endopeptidase activity GO:0004175 9.33 ADAM17 PLG REN
3 protease binding GO:0002020 9.26 F3 SERPINC1 SERPINE1 VWF
4 signaling receptor binding GO:0005102 9.1 EDN1 F2 JAK2 PLG REN SERPINE1

Sources for Hepatic Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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