MCID: HPT020
MIFTS: 39

Hepatic Vascular Disease

Categories: Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hepatic Vascular Disease

MalaCards integrated aliases for Hepatic Vascular Disease:

Name: Hepatic Vascular Disease 12 15
Vascular Disorder of Liver 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:272
NCIt 50 C35442
UMLS 73 C0400923

Summaries for Hepatic Vascular Disease

Disease Ontology : 12 A vascular disease that is located in the liver.

MalaCards based summary : Hepatic Vascular Disease, also known as vascular disorder of liver, is related to hepatic veno-occlusive disease and portal hypertension. An important gene associated with Hepatic Vascular Disease is ALB (Albumin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Immune response IL-23 signaling pathway. Affiliated tissues include liver, kidney and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Hepatic Vascular Disease

Diseases related to Hepatic Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 hepatic veno-occlusive disease 31.0 F3 PLG SERPINC1 SERPINE1 SP110
2 portal hypertension 29.1 ALB EDN1 F2 JAK2 NOS3 SST
3 vascular disease 28.5 ALB EDN1 F2 F3 MTHFR NOS3
4 abdominal tuberculosis 10.3 ALB F2
5 kwashiorkor 10.3 ALB F2
6 hepatic tuberculosis 10.3 ALB F2
7 chronic thromboembolic pulmonary hypertension 10.3 EDN1 F2
8 prothrombin deficiency, congenital 10.3 F2 SERPINC1
9 yellow nail syndrome 10.3 ALB SST
10 hepatoid adenocarcinoma 10.3 AFP ALB
11 endometrial small cell carcinoma 10.3 AFP F2
12 liver sarcoma 10.3 ADAM17 AFP
13 antipyrine metabolism 10.3 ALB F2
14 non-a-e hepatitis 10.3 ALB F2
15 chronic myocardial ischemia 10.3 NOS3 PLG
16 orthostatic proteinuria 10.3 ALB REN
17 perinephritis 10.3 EDN1 REN
18 renal artery disease 10.3 NOS3 REN
19 epstein-barr virus hepatitis 10.3 ALB F2
20 postural hypotension 10.3 REN SST
21 mediastinal cancer 10.2 AFP CD33
22 endocarditis 10.2 ALB F2 SERPINC1
23 brachydactyly, type d 10.2 F2 VWF
24 hyperglycemia 10.2 ALB NOS3 SST
25 active peptic ulcer disease 10.2 F2 VWF
26 raynaud disease 10.2 EDN1 VWF
27 platelet aggregation, spontaneous 10.2 SERPINC1 VWF
28 sticky platelet syndrome 10.2 SERPINC1 SERPINE1
29 hypersplenism 10.2 ALB F2 SERPINC1
30 dysfibrinogenemia 10.2 ALB F2 SERPINC1
31 chronic mountain sickness 10.2 EDN1 NOS3 SST
32 acquired von willebrand syndrome 10.2 JAK2 VWF
33 tuberculous empyema 10.2 PLG SERPINE1
34 bile duct disease 10.2 AFP ALB F2
35 hepatitis a 10.2 AFP ALB F2
36 renal artery obstruction 10.2 REN SERPINC1
37 renovascular hypertension 10.2 EDN1 NOS3 REN
38 hypertensive retinopathy 10.2 REN VWF
39 alpha-2-plasmin inhibitor deficiency 10.2 F2 PLG SERPINC1
40 biliary tract disease 10.2 AFP ALB F2
41 benign essential hypertension 10.2 ALB REN
42 intracranial embolism 10.2 F2 PLG SERPINC1
43 anterior spinal artery syndrome 10.2 F2 PLG SERPINC1
44 alcoholic liver cirrhosis 10.2 AFP ALB F2
45 renal hypertension 10.2 ALB EDN1 REN
46 fibrinolytic defect 10.1 SERPINC1 SERPINE1
47 kidney papillary necrosis 10.1 ALB REN
48 viral hepatitis 10.1 AFP ALB F2
49 conjugate gaze palsy 10.1 F3 PLG
50 analbuminemia 10.1 ALB F2 F3

Graphical network of the top 20 diseases related to Hepatic Vascular Disease:



Diseases related to Hepatic Vascular Disease

Symptoms & Phenotypes for Hepatic Vascular Disease

MGI Mouse Phenotypes related to Hepatic Vascular Disease:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ADAM17 AFP ALB EDN1 F2 F3
2 growth/size/body region MP:0005378 10.24 ADAM17 EDN1 F2 F3 JAK2 MTHFR
3 mortality/aging MP:0010768 10.24 ADAM17 AFP ALB EDN1 F2 F3
4 cardiovascular system MP:0005385 10.22 ADAM17 EDN1 F2 F3 NOS3 PLG
5 hematopoietic system MP:0005397 10.18 ADAM17 F2 F3 JAK2 NOS3 PLG
6 immune system MP:0005387 10.17 ADAM17 F2 F3 JAK2 NOS3 PLG
7 digestive/alimentary MP:0005381 10.11 ADAM17 ALB EDN1 F2 NOS3 PLG
8 liver/biliary system MP:0005370 10.01 AFP ALB JAK2 MTHFR NOS3 PLG
9 nervous system MP:0003631 10 ADAM17 EDN1 F2 F3 MTHFR NOS3
10 normal MP:0002873 9.81 ADAM17 ALB EDN1 F2 F3 JAK2
11 neoplasm MP:0002006 9.8 AFP ALB F3 JAK2 PLG SERPINE1
12 renal/urinary system MP:0005367 9.5 ALB EDN1 NOS3 PLG REN SERPINC1
13 reproductive system MP:0005389 9.28 ADAM17 AFP F2 JAK2 MTHFR NOS3

Drugs & Therapeutics for Hepatic Vascular Disease

Search Clinical Trials , NIH Clinical Center for Hepatic Vascular Disease

Genetic Tests for Hepatic Vascular Disease

Anatomical Context for Hepatic Vascular Disease

MalaCards organs/tissues related to Hepatic Vascular Disease:

41
Liver, Kidney, Heart, Spinal Cord, Pancreas, Cortex, Adrenal Gland

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatic Vascular Disease:

19
The Liver

Publications for Hepatic Vascular Disease

Articles related to Hepatic Vascular Disease:

# Title Authors Year
1
A Comprehensive Approach to Hepatic Vascular Disease. ( 28430541 )
2017
2
Hepatic vascular disease and portal hypertension in polycythemia vera and agnogenic myeloid metaplasia: a clinicopathological study of 145 patients examined at autopsy. ( 2227815 )
1990
3
Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature. ( 3114679 )
1987

Variations for Hepatic Vascular Disease

Expression for Hepatic Vascular Disease

Search GEO for disease gene expression data for Hepatic Vascular Disease.

Pathways for Hepatic Vascular Disease

Pathways related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 ALB F2 F3 JAK2 NOS3 PLG
2
Show member pathways
12.31 F2 JAK2 NOS3 PLG
3
Show member pathways
12.05 ALB F2 MTHFR PLG SERPINE1
4 11.76 F3 PLG SERPINE1
5 11.63 EDN1 NOS3 SERPINE1
6
Show member pathways
11.63 F2 F3 PLG SERPINC1 SERPINE1 VWF
7 11.62 F3 NOS3 REN VWF
8 11.55 EDN1 F3 JAK2 NOS3 SERPINE1
9 11.24 F2 F3 PLG SERPINC1 SERPINE1 VWF
10 11.22 AFP ALB F2
11 10.55 PLG SERPINE1

GO Terms for Hepatic Vascular Disease

Cellular components related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.71 AFP ALB F2 SERPINC1
2 collagen-containing extracellular matrix GO:0062023 9.65 F3 PLG SERPINC1 SERPINE1 VWF
3 extracellular space GO:0005615 9.65 AFP ALB EDN1 F2 F3 PLG
4 blood microparticle GO:0072562 9.62 ALB F2 PLG SERPINC1
5 platelet alpha granule lumen GO:0031093 9.46 ALB PLG SERPINE1 VWF
6 Weibel-Palade body GO:0033093 9.37 EDN1 VWF
7 extracellular region GO:0005576 9.36 AFP ALB EDN1 F2 F3 PLG

Biological processes related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.89 CD33 JAK2 NOS3 PLG SST
2 positive regulation of cell migration GO:0030335 9.84 ADAM17 EDN1 F3 JAK2
3 response to drug GO:0042493 9.83 ADAM17 EDN1 MTHFR REN SST
4 cellular protein metabolic process GO:0044267 9.72 AFP ALB F2 PLG SERPINC1
5 platelet degranulation GO:0002576 9.71 ALB PLG SERPINE1 VWF
6 regulation of blood pressure GO:0008217 9.69 EDN1 NOS3 REN
7 response to lipopolysaccharide GO:0032496 9.65 ADAM17 EDN1 JAK2 NOS3 REN
8 response to amino acid GO:0043200 9.63 EDN1 MTHFR SST
9 regulation of blood vessel size GO:0050880 9.59 EDN1 NOS3
10 blood coagulation, intrinsic pathway GO:0007597 9.58 F2 VWF
11 negative regulation of blood coagulation GO:0030195 9.58 EDN1 SERPINE1
12 positive regulation of blood coagulation GO:0030194 9.57 F2 SERPINE1
13 regulation of blood coagulation GO:0030193 9.56 F2 SERPINC1
14 negative regulation of platelet activation GO:0010544 9.55 F2 NOS3
15 fibrinolysis GO:0042730 9.54 F2 PLG SERPINE1
16 ovulation from ovarian follicle GO:0001542 9.52 AFP NOS3
17 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.48 EDN1 NOS3
18 blood coagulation GO:0007596 9.43 F2 F3 JAK2 PLG SERPINC1 VWF
19 negative regulation of fibrinolysis GO:0051918 9.33 F2 PLG SERPINE1
20 hemostasis GO:0007599 9.02 F2 F3 PLG SERPINC1 VWF

Molecular functions related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.43 ALB PLG VWF
2 endopeptidase activity GO:0004175 9.33 ADAM17 PLG REN
3 protease binding GO:0002020 9.26 F3 SERPINC1 SERPINE1 VWF
4 signaling receptor binding GO:0005102 9.1 EDN1 F2 JAK2 PLG REN SERPINE1

Sources for Hepatic Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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