MCID: HPT020
MIFTS: 35

Hepatic Vascular Disease

Categories: Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatic Vascular Disease

MalaCards integrated aliases for Hepatic Vascular Disease:

Name: Hepatic Vascular Disease 12 15
Vascular Disorder of Liver 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:272
NCIt 50 C35442
UMLS 72 C0400923

Summaries for Hepatic Vascular Disease

Disease Ontology : 12 A vascular disease that is located in the liver.

MalaCards based summary : Hepatic Vascular Disease, also known as vascular disorder of liver, is related to portal vein thrombosis and hepatic veno-occlusive disease. An important gene associated with Hepatic Vascular Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Immune response IL-23 signaling pathway. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Hepatic Vascular Disease

Diseases in the Hepatic Vascular Disease family:

Rare Vascular Liver Disease

Diseases related to Hepatic Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 portal vein thrombosis 30.8 SERPINE1 SERPINC1 MTHFR JAK2 F2 AFP
2 hepatic veno-occlusive disease 30.6 SP110 SERPINE1 SERPINC1 PLG F3
3 hepatoportal sclerosis 30.6 GPT F2
4 esophageal varix 29.7 SST SERPINC1 F2 ALB AFP
5 hepatopulmonary syndrome 29.7 VWF NOS3 EDN1 ALB
6 budd-chiari syndrome 29.3 SERPINC1 MTHFR JAK2 F3 F2
7 varicose veins 29.2 VWF SERPINC1 MTHFR F2
8 thrombophlebitis 28.8 SERPINE1 SERPINC1 MTHFR F2
9 portal hypertension 28.3 VWF SST NOS3 JAK2 GPT F2
10 blood coagulation disease 27.7 VWF SERPINC1 PLG MTHFR JAK2 F3
11 vein disease 26.7 SST SERPINE1 SERPINC1 PLG MTHFR F3
12 vascular disease 26.2 VWF SERPINE1 SERPINC1 REN PLG NOS3
13 non-a-e hepatitis 10.8 F2 ALB
14 antipyrine metabolism 10.8 F2 ALB
15 epstein-barr virus hepatitis 10.8 F2 ALB
16 abdominal tuberculosis 10.7 F2 ALB
17 endocarditis 10.6 SERPINC1 F2 ALB
18 hepatic tuberculosis 10.6 GPT F2 ALB
19 kwashiorkor 10.6 GPT F2 ALB
20 hepatic coma 10.6 GPT F2 ALB
21 infantile liver failure syndrome 1 10.6 GPT F2 ALB
22 biliary tract disease 10.6 F2 ALB AFP
23 endometrial small cell carcinoma 10.6 F2 AFP
24 choledocholithiasis 10.6 GPT F2 ALB
25 benign essential hypertension 10.6 REN ALB
26 hypersplenism 10.6 SERPINC1 F2 ALB
27 acute liver failure 10.6 GPT F2 ALB
28 hepatitis e 10.5 GPT F2 ALB
29 alcoholic liver cirrhosis 10.5 F2 ALB AFP
30 kidney papillary necrosis 10.5 REN ALB
31 dysfibrinogenemia 10.5 SERPINC1 F2 ALB
32 bilirubin metabolic disorder 10.5 GPT F2 ALB
33 cholecystitis 10.5 GPT F2 ALB
34 hepatic encephalopathy 10.5 GPT F2 ALB
35 alcoholic hepatitis 10.5 GPT F2 ALB
36 renal artery obstruction 10.5 SERPINC1 REN
37 wilson disease 10.5 GPT F2 ALB
38 gastrointestinal system cancer 10.5 F2 ALB AFP
39 cholangitis 10.5 GPT F2 ALB
40 chronic mountain sickness 10.5 SST NOS3 EDN1
41 perinephritis 10.5 REN EDN1
42 prothrombin deficiency, congenital 10.5 SERPINC1 F2
43 angina pectoris 10.5 SERPINC1 NOS3 EDN1
44 prothrombin deficiency 10.5 F3 F2
45 cerebral sinovenous thrombosis 10.5 F3 F2
46 intracranial embolism 10.5 SERPINC1 PLG F2
47 renovascular hypertension 10.5 REN NOS3 EDN1
48 alpha-2-plasmin inhibitor deficiency 10.5 SERPINC1 PLG F2
49 renal hypertension 10.4 REN EDN1 ALB
50 anterior spinal artery syndrome 10.4 SERPINC1 PLG F2

Graphical network of the top 20 diseases related to Hepatic Vascular Disease:



Diseases related to Hepatic Vascular Disease

Symptoms & Phenotypes for Hepatic Vascular Disease

MGI Mouse Phenotypes related to Hepatic Vascular Disease:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 AFP ALB EDN1 F2 F3 JAK2
2 mortality/aging MP:0010768 10.21 AFP ALB EDN1 F2 F3 JAK2
3 cardiovascular system MP:0005385 10.15 EDN1 F2 F3 NOS3 PLG REN
4 immune system MP:0005387 10.13 F2 F3 JAK2 NOS3 PLG REN
5 digestive/alimentary MP:0005381 10.02 ALB EDN1 F2 NOS3 PLG SST
6 liver/biliary system MP:0005370 10.01 AFP ALB JAK2 MTHFR NOS3 PLG
7 nervous system MP:0003631 9.96 EDN1 F2 F3 MTHFR NOS3 PLG
8 neoplasm MP:0002006 9.8 AFP ALB F3 JAK2 PLG SERPINE1
9 normal MP:0002873 9.76 ALB EDN1 F2 F3 JAK2 NOS3
10 renal/urinary system MP:0005367 9.5 ALB EDN1 NOS3 PLG REN SERPINC1
11 reproductive system MP:0005389 9.23 AFP F2 JAK2 MTHFR NOS3 PLG

Drugs & Therapeutics for Hepatic Vascular Disease

Drugs for Hepatic Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vascular Liver Disease Evaluation, Follow Up and Non-Invasive Diagnostics Program Recruiting NCT03717792

Search NIH Clinical Center for Hepatic Vascular Disease

Genetic Tests for Hepatic Vascular Disease

Anatomical Context for Hepatic Vascular Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatic Vascular Disease:

19
Liver

MalaCards organs/tissues related to Hepatic Vascular Disease:

41
Liver, Kidney, Myeloid

Publications for Hepatic Vascular Disease

Articles related to Hepatic Vascular Disease:

# Title Authors PMID Year
1
Expert consensus on the clinical management of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome. 38
30669184 2019
2
A Comprehensive Approach to Hepatic Vascular Disease. 38
28430541 2017
3
Extrahepatic portal vein obstruction and portal vein thrombosis in special situations: Need for a new classification. 38
26021771 2015
4
Magnetic resonance (MR) imaging and MR angiography for evaluation and follow-up of hepatic artery banding in patients with hepatic involvement of hereditary hemorrhagic telangiectasia. 38
16465571 2006
5
Hepatic vascular disease and portal hypertension in polycythemia vera and agnogenic myeloid metaplasia: a clinicopathological study of 145 patients examined at autopsy. 38
2227815 1990
6
Fatal hepatic vascular toxicity of DTIC. Is it really a rare event? 38
3359400 1988
7
Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature. 38
3114679 1987

Variations for Hepatic Vascular Disease

Expression for Hepatic Vascular Disease

Search GEO for disease gene expression data for Hepatic Vascular Disease.

Pathways for Hepatic Vascular Disease

Pathways related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 VWF SERPINE1 SERPINC1 PLG NOS3 JAK2
2
Show member pathways
12.31 PLG NOS3 JAK2 F2
3
Show member pathways
12.05 SERPINE1 PLG MTHFR F2 ALB
4 11.76 SERPINE1 PLG F3
5 11.67 SERPINE1 NOS3 EDN1
6
Show member pathways
11.63 VWF SERPINE1 SERPINC1 PLG F3 F2
7 11.62 VWF REN NOS3 F3
8 11.55 SERPINE1 NOS3 JAK2 F3 EDN1
9 11.24 VWF SERPINE1 SERPINC1 PLG F3 F2
10 11.22 F2 ALB AFP
11 10.55 SERPINE1 PLG

GO Terms for Hepatic Vascular Disease

Cellular components related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.71 SERPINC1 F2 ALB AFP
2 extracellular region GO:0005576 9.7 VWF SST SERPINE1 SERPINC1 REN PLG
3 collagen-containing extracellular matrix GO:0062023 9.65 VWF SERPINE1 SERPINC1 PLG F3
4 blood microparticle GO:0072562 9.62 SERPINC1 PLG F2 ALB
5 platelet alpha granule lumen GO:0031093 9.46 VWF SERPINE1 PLG ALB
6 Weibel-Palade body GO:0033093 9.37 VWF EDN1
7 extracellular space GO:0005615 9.36 SST SERPINE1 SERPINC1 REN PLG GPT

Biological processes related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 SST PLG NOS3 JAK2 CD33
2 response to drug GO:0042493 9.87 SST REN MTHFR EDN1
3 response to lipopolysaccharide GO:0032496 9.73 REN NOS3 JAK2 EDN1
4 regulation of blood pressure GO:0008217 9.67 REN NOS3 EDN1
5 platelet degranulation GO:0002576 9.67 VWF SERPINE1 PLG ALB
6 cellular protein metabolic process GO:0044267 9.65 SERPINC1 PLG F2 ALB AFP
7 regulation of blood vessel size GO:0050880 9.58 NOS3 EDN1
8 blood coagulation, intrinsic pathway GO:0007597 9.58 VWF F2
9 response to amino acid GO:0043200 9.58 SST MTHFR EDN1
10 negative regulation of blood coagulation GO:0030195 9.56 SERPINE1 EDN1
11 regulation of blood coagulation GO:0030193 9.55 SERPINC1 F2
12 positive regulation of blood coagulation GO:0030194 9.54 SERPINE1 F2
13 negative regulation of platelet activation GO:0010544 9.52 NOS3 F2
14 ovulation from ovarian follicle GO:0001542 9.51 NOS3 AFP
15 fibrinolysis GO:0042730 9.5 SERPINE1 PLG F2
16 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.46 NOS3 EDN1
17 blood coagulation GO:0007596 9.43 VWF SERPINC1 PLG JAK2 F3 F2
18 negative regulation of fibrinolysis GO:0051918 9.33 SERPINE1 PLG F2
19 hemostasis GO:0007599 9.02 VWF SERPINC1 PLG F3 F2

Molecular functions related to Hepatic Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.33 VWF PLG ALB
2 protease binding GO:0002020 9.26 VWF SERPINE1 SERPINC1 F3
3 signaling receptor binding GO:0005102 9.1 SERPINE1 REN PLG JAK2 F2 EDN1

Sources for Hepatic Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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