Hepatitis B disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

HBV MCID: HPT016 MIFTS: 63	Hepatitis B (HBV) Categories: Cancer diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Liver diseases, Nephrological diseases, Oral diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Hepatitis B

MalaCards integrated aliases for Hepatitis B:

Name: Hepatitis B ¹¹ ⁷⁵ ⁵³ ⁴¹ ⁴³ ¹⁴ ³⁶ ⁷¹

Hepatitis B Infection ¹¹ ¹⁴

Chronic Hepatitis B ¹¹ ³³

Chronic Hbv - [hepatitis B Virus] Infection ³³

Chronic Hepatitis B Without Delta Agent ³³

Chronic Type B Viral Hepatitis ³³

Hbv, Susceptibility to ⁵

Hepatitis B, Chronic ⁷¹

Hepatitis B Chronic ⁵³

Serum Hepatitis ¹¹

Hepatitis B Nos ³³

Hep B Nos ³³

Hbv ⁴⁷

Classifications:

MalaCards categories:
Global: Infectious diseases Genetic diseases Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases Immune diseases Nephrological diseases Oral diseases

See all MalaCards categories (disease lists)

ICD11: ³³

Certain infectious or parasitic diseases

Viral hepatitis

Chronic viral hepatitis

Chronic hepatitis B

Chronic hepatitis B with human immunodeficiency virus co-infection

Chronic hepatitis B, unspecified

Other specified chronic hepatitis B

External Ids:

Disease Ontology ¹¹ DOID:2043

MeSH ⁴³ D006509

NCIt ⁴⁹ C3097

SNOMED-CT ⁶⁸ 66071002

ICD11 ³³ 1994012056 352087872 352087872/other more

UMLS ⁷¹ C0019163 C0524909

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Summaries for Hepatitis B

MedlinePlus: ⁴¹ What is hepatitis? Hepatitis is inflammation of the liver. Inflammation is swelling that happens when tissues of the body are injured or infected. It can damage your liver. This swelling and damage can affect how well your liver functions. What is hepatitis B? Hepatitis B is a type of viral hepatitis. It can cause an acute (short-term) or chronic (long-term) infection. People with an acute infection usually get better on their own without treatment. Some people with chronic hepatitis B will need treatment. Thanks to a vaccine, hepatitis B is not very common in the United States. It is more common in certain parts of the world, such as sub-Saharan Africa and parts of Asia. What causes hepatitis B? Hepatitis B is caused by the hepatitis B virus. The virus spreads through contact with blood, semen, or other body fluids from a person who has the virus. Who is at risk for hepatitis B? Anyone can get hepatitis B, but the risk is higher in: Infants born to mothers who have hepatitis B People who inject drugs or share needles, syringes, and other types of drug equipment Sex partners of people with hepatitis B, especially if they are not using latex or polyurethane condoms during sex Men who have sex with men People who live with someone who has hepatitis B, especially if they use the same razor, toothbrush, or nail clippers Health care and public-safety workers who are exposed to blood on the job Hemodialysis patients People who have lived in or traveled often to parts of the world where hepatitis B is common Have diabetes, hepatitis C, or HIV What are the symptoms of hepatitis B? Often, people with hepatitis B don't have symptoms. Adults and children over 5 are more likely to have symptoms than younger children. Some people with acute hepatitis B have symptoms 2 to 5 months after infection. These symptoms can include: Dark yellow urine Diarrhea Fatigue Fever Gray- or clay-colored stools Joint pain Loss of appetite Nausea and/or vomiting Abdominal pain Yellowish eyes and skin, called jaundice If you have chronic hepatitis B, you may not have symptoms until complications develop. This could be decades after you were infected. For this reason, hepatitis B screening is important, even if you have no symptoms. Screening means that you are tested for a disease even though you don't have symptoms. If you are at high risk, your health care provider may suggest screening. What other problems can hepatitis B cause? In rare cases, acute hepatitis B can cause liver failure. Chronic hepatitis B can develop into a serious disease that causes long-term health problems such as cirrhosis (scarring of the liver), liver cancer, and liver failure. If you have ever had hepatitis B, the virus may become active again, or reactivated, later in life. This could start to damage the liver and cause symptoms. How is hepatitis B diagnosed? To diagnose hepatitis B, your health care provider may use many tools to make a diagnosis: A medical history, which includes asking about your symptoms A physical exam Blood tests, including tests for viral hepatitis What are the treatments for hepatitis B? If you have acute hepatitis B, you probably don't need treatment. Some people with chronic hepatitis B don't need treatment. But if you have a chronic infection and blood tests show that hepatitis B could be damaging your liver, you may need to take antiviral medicines. Can hepatitis B be prevented? The best way to prevent hepatitis B is to get the hepatitis B vaccine. You can also reduce your chance of hepatitis B infection by: Not sharing drug needles or other drug materials Wearing gloves if you have to touch another person's blood or open sores Making sure your tattoo artist or body piercer uses sterile tools Not sharing personal items, such as toothbrushes, razors, or nail clippers Using a latex condom during sex. If your or your partner is allergic to latex, you can use polyurethane condoms. If you think you have been in contact with the hepatitis B virus, see your health care provider right away. Your provider may give you a dose of the hepatitis B vaccine to prevent infection. In some cases, your provider may also give you a medicine called hepatitis B immune globulin (HBIG). You need to get the vaccine and the HBIG (if needed) as soon as possible after coming into contact with the virus. It is best if you can get them within 24 hours. National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary: Hepatitis B, also known as hepatitis b infection, is related to hepatitis and hepatitis d, and has symptoms including fever, nausea and vomiting and constipation. An important gene associated with Hepatitis B is MIR21 (MicroRNA 21), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Overview of interferons-mediated signaling pathway. The drugs Glycyrrhizic acid and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and t cells, and related phenotypes are neoplasm and endocrine/exocrine gland

Disease Ontology: ¹¹ A viral infectious disease that results in inflammation located in liver, has material basis in Hepatitis B virus, which is transmitted by sexual contact, blood transfusions, or fomites like needles or syringes. The infection has symptom fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, and jaundice.

Wikipedia: ⁷⁵ Hepatitis B is an infectious disease caused by the Hepatitis B virus (HBV) that affects the liver; it is... more...

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Related Diseases for Hepatitis B

Diseases in the Hepatitis family:

Hepatitis C Virus	Hepatitis a
Hepatitis C	Viral Hepatitis
Hepatitis B	Hepatitis D
Autoimmune Hepatitis	Hepatitis E
Autoimmune Hepatitis Type 2	Autoimmune Hepatitis Type 1

Diseases related to Hepatitis B via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1572)

#	Related Disease	Score	Top Affiliating Genes
1	hepatitis	33.3	SLC10A1 RSF1 NR5A2 LAMTOR5 IFNA2 IFNA1
2	hepatitis d	33.2	SLC10A1 IFNA2 IFNA1 GPT
3	viral hepatitis	33.0	IFNA2 IFNA1 GPT F2 ALB AFP
4	liver cirrhosis	32.8	IFNA1 GPT F2 ALB AFP
5	viral infectious disease	32.7	MIR21 IFNAR2 IFNA2 IFNA1 GPT
6	hepatitis a	32.7	IFNA2 IFNA1 GPT F2 ALB AFP
7	liver disease	32.6	SLC10A1 MIR21 IFNA2 IFNA1 GPT F2
8	hepatitis c	32.5	IFNAR2 IFNA2 IFNA1 GPT F2 AFP
9	hepatic encephalopathy	31.9	GPT F2 ALB
10	hepatitis e	31.9	GPT F2 ALB
11	alcohol use disorder	31.8	GPT F2 ALB AFP
12	portal hypertension	31.7	GPT F2 ALB AFP
13	cryoglobulinemia	31.6	IFNA2 IFNA1 GPT
14	alcoholic liver cirrhosis	31.6	GPT F2 ALB AFP
15	schistosomiasis	31.6	IFNGR1 GPT F2 ALB
16	esophageal varix	31.6	GPT F2 ALB AFP
17	hepatocellular carcinoma	31.6	RSF1 MIR301A MIR21 MIR17 IFNAR2 IFNA2
18	exanthem	31.5	IFNA1 GPT F2 ALB
19	cryoglobulinemia, familial mixed	31.5	IFNA2 IFNA1
20	hepatorenal syndrome	31.5	GPT F2 ALB AFP
21	deficiency anemia	31.5	IFNA2 IFNA1 GPT F2 ALB
22	portal vein thrombosis	31.5	GPT F2 ALB AFP
23	chickenpox	31.5	IFNA1 GPT F2 ALB
24	autoimmune hepatitis	31.5	GPT F2 ALB
25	bilirubin metabolic disorder	31.4	SLC10A1 GPT F2 ALB AFP
26	non-alcoholic steatohepatitis	31.4	MIR21 GPT ALB AFP
27	immune deficiency disease	31.3	MIR21 MIR17 IFNGR1 IFNA1 GPT APOBEC3G
28	rubella	31.3	IL10RB IFNAR2 GPT
29	thrombocytopenia	31.3	MIR21 IFNA2 IFNA1 GPT F2 ALB
30	hypothyroidism	31.3	IFNA2 IFNA1 GPT F2 ALB AFP
31	intrahepatic cholestasis	31.3	GPT ALB AFP
32	hepatic coma	31.2	GPT F2 ALB AFP
33	dengue disease	31.2	IFNA1 GPT ALB
34	acute kidney failure	31.2	GPT F2 ALB
35	substance abuse	31.2	GPT F2 ALB AFP
36	cholangitis	31.2	GPT F2 ALB
37	hypersplenism	31.2	GPT F2 ALB AFP
38	intrahepatic cholestasis of pregnancy	31.1	SLC10A1 NR5A2 GPT
39	alcoholic hepatitis	31.1	GPT F2 ALB
40	cholecystitis	31.1	GPT F2 ALB
41	hemochromatosis, type 1	31.1	GPT F2 ALB AFP
42	malaria	31.1	IFNGR1 IFNA2 IFNA1 GPT F2 ALB
43	drug-induced hepatitis	31.1	GPT F2 ALB AFP
44	diarrhea	31.0	IFNA2 IFNA1 GPT ALB
45	biliary atresia	31.0	SLC10A1 GPT F2 ALB
46	neutropenia	31.0	IFNA2 IFNA1 GPT ALB
47	intrahepatic cholangiocarcinoma	31.0	MIR17 ALB AFP
48	hyperthyroidism	30.9	GPT F2 ALB
49	budd-chiari syndrome	30.9	GPT F2 ALB AFP
50	primary biliary cholangitis	30.9	SLC10A1 MIR17 GPT F2 ALB AFP

Graphical network of the top 20 diseases related to Hepatitis B:

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Symptoms & Phenotypes for Hepatitis B

Symptoms:

¹¹

• fever

UMLS symptoms related to Hepatitis B:

nausea and vomiting; constipation; fever; abdominal pain; pruritus; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

MGI Mouse Phenotypes related to Hepatitis B:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.7	AFP AIP ALB APOBEC3G IFNAR2 IFNGR1
2	endocrine/exocrine gland	MP:0005379	9.65	AFP AIP ALB DDB1 F2 IFNGR1
3	mortality/aging	MP:0010768	9.47	AIP ALB APOBEC3G CPD DDB1 F2

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Drugs & Therapeutics for Hepatitis B

Drugs for Hepatitis B (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 355)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Glycyrrhizic acid

Approved, Experimental

Phase 4

1405-86-3

3495 14982

Chlorhexidine

Approved, Vet_approved, Withdrawn

Phase 4

55-56-1

2713 9552079

Alprostadil

Approved, Investigational

Phase 4

745-65-3

5280723

Tocopherol

Approved, Investigational

Phase 4

1406-66-2

Atorvastatin

Approved

Phase 4

134523-00-5

60823

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

6473866 445643

Ethiodized oil

Approved, Investigational

Phase 4

8008-53-5

Lenograstim

Approved, Investigational

Phase 4

135968-09-1

Framycetin

Approved, Experimental, Vet_approved

Phase 4

1404-04-2, 119-04-0, 3947-65-7

413349 8378

Carvedilol

Approved, Investigational

Phase 4

72956-09-3

2585

Mycophenolic acid

Approved, Investigational

Phase 4

24280-93-1

446541

Simethicone

Approved

Phase 4

8050-81-5

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

Ribavirin

Approved

Phase 4

36791-04-5

37542

Zidovudine

Approved

Phase 4

30516-87-1

35370

Iron

Approved

Phase 4

7439-89-6

29936

Edetate calcium disodium anhydrous

Approved, Vet_approved

Phase 4

62-33-9, 60-00-4

6049

Pentetic acid

Approved

Phase 4

67-43-6

Empagliflozin

Approved

Phase 4

864070-44-0

73151030 11949646

Velpatasvir

Approved, Investigational

Phase 4

1377049-84-7

77335690 67683363

Sofosbuvir

Approved

Phase 4

1190307-88-0

45375808

Racivir

Approved, Investigational

Phase 4

143491-57-0, 143491-54-7

60877

Pioglitazone

Approved, Investigational

Phase 4

111025-46-8

4829

Parathyroid hormone

Approved, Investigational

Phase 4

9002-64-6

Calcium carbonate

Approved, Investigational

Phase 4

471-34-1

Methadone

Approved

Phase 4

76-99-3, 1095-90-5

4095

Lecithin

Approved, Experimental, Investigational, Nutraceutical

Phase 4

8002-43-5, 1446756-47-3, 18656-38-7

26197 9547096 6323481

DL-alpha-Tocopherol

Approved, Experimental, Investigational, Nutraceutical, Vet_approved

Phase 4

59-02-9, 10191-41-0

2116 14985

Aspartic acid

Approved, Nutraceutical

Phase 4

56-84-8

5960

Racemethionine

Approved, Experimental, Investigational, Nutraceutical

Phase 4

59-51-8, 63-68-3, 348-67-4

6137

D-Tyrosine

Approved, Experimental, Investigational, Nutraceutical

Phase 4

133585-56-5, 60-18-4, 556-02-5

1153 6057

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

Ergocalciferol

Approved, Nutraceutical

Phase 4

50-14-6

5280793

(3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium

Experimental

Phase 4

461-06-3

Chlorotrianisene

Investigational, Withdrawn

Phase 4

569-57-3

11289

Tocotrienol

Investigational

Phase 4

6829-55-6

9929901

Thymalfasin

Investigational

Phase 4

62304-98-7

16167214 16130571

Oxymatrine

Investigational

Phase 4

16837-52-8

Clevudine

Investigational

Phase 4

163252-36-6

Neurotransmitter Agents

Phase 4

Anesthetics

Phase 4

Protective Agents

Phase 4

Chlorhexidine gluconate

Phase 4

Antimetabolites

Phase 4

Antitubercular Agents

Phase 4

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 4

Polyene phosphatidylcholine

Phase 4

Essential 303 forte

Phase 4

Antihypertensive Agents

Phase 4

Hypolipidemic Agents

Phase 4

Interventional clinical trials:

(show top 50) (show all 1560)

#	Name	Status	NCT ID	Phase	Drugs
1	PhaseIVstudy to Evaluate the Non-inferiority of Cavir®Tab. in Terms of Hepatitis B Virus(HBV)DNA Undetectability Comparing Baraclude® Tab. in Hepatitis B e Antigen(HBeAg)(+) Chronic Hepatitis B Patients Treated With Long-term Baraclude® Tab	Unknown status	NCT02523547	Phase 4	Cavir;Baraclude
2	Propylactic Use of Entecavir for Biological Agents Associated Hepatitis B Virus Reactivation in Inflammatory Arthritis Patients: a Randomized Controlled Trial	Unknown status	NCT01907230	Phase 4	Entecavir
3	Combination or Sequential Therapy of Peginterferon Alfa-2a and Entecavir for Hepatitis B e Antigen-positive Patients With Chronic Hepatitis B	Unknown status	NCT01906580	Phase 4	Peg-IFNα-2a;Entecavir
4	Pegasys Plus Entecavir Versus Entecavir Versus Pegasys for Hepatitis B e Antigen-Negative Chronic Hepatitis B	Unknown status	NCT01925820	Phase 4	Pegasys&Entecavir
5	Entecavir Combined Short-term Intravenous Hepatitis B Immune Globulin (HBIG) to Prevent Hepatitis B Recurrence After Liver Transplantation	Unknown status	NCT02417207	Phase 4	Entecavir combined long-term low-dose HBIG group intramuscular;Entecavir combined HBIG group short-term high-dose intravenous
6	The Efficacy and Safety of the Anti Hepatitis B Placenta Transfer Factor Injection in the Treatment of HBeAg Positive Chronic Hepatitis B, Randomized, Double Blind, Placebo Controlled, Multi Center Clinical Trial	Unknown status	NCT02412319	Phase 4	Anti-HBV placenta transfer factor injection
7	Maintaining Antiviral Efficacy After Switching to Generic Entecavir, Baracle® in Patients Taking Baraclude® 1 mg for Antiviral Resistant Chronic Hepatitis B; A Noninferiority Study Assessing Non-detection Rate of Hepatitis B Virus DNA	Unknown status	NCT04069858	Phase 4	Switching to Generic Entecavir (Baracle®)
8	Project to Evaluate Hepatitis B Vaccine-induced Immunity Among US-born Adolescents Who Received Hepatitis B Primary Vaccination Series During Early Childhood	Unknown status	NCT01341275	Phase 4
9	A Clinical Evaluation on Traditional Chinese Medicine Diagnosis and Treatment Program Blocking and Reversing Hepatitis B-related Liver Fibrosis - a Randomized, Controlled, Double-blind, Multi-center Clinical Trial	Unknown status	NCT01965418	Phase 4	Fufang Biejia Ruangan Tablet;Placebo
10	The Efficacy and Safety Study of Magnesium Isoglycyrrhizinate Injection Followed by Diammonium Glycyrrhizinate Enteric-coated Capsules and Combined With Entecavir on the Treatment of Chronic Hepatitis B	Unknown status	NCT03349008	Phase 4	Entecavir;Magnesium Isoglycyrrhizinate;Diammonium Glycyrrhizinate;Magnesium Isoglycyrrhizinate Placebo;Diammonium Glycyrrhizinate Placebo
11	The Effect of Entecavir Consolidation on Post-TDF Treatment Durability	Unknown status	NCT03308890	Phase 4	0.5mg Baraclude(entecavir)
12	Prospective, Multicenter, Randomized, and Comparative Clinical Trials to Compare the Effects of Pioglitazone and Evogliptin on Hepatic Fibrosis in Patients With Chronic Hepatitis B With Significant Hepatic Fibrosis With Type 2 Diabetes	Unknown status	NCT04584242	Phase 4	gluconon tab 15mg;suganon tab 5mg
13	A 3-year, Open-lable, Multi-center Extension Trial of Entecavir Plus Adefovir Combination Treatment for Patients Previously Treated in EXPLORE, EXCEL and EFFORT Ex Study	Unknown status	NCT01834508	Phase 4	oral entecavir 0.5mg daily and adefovir 10mg daily for 144 weeks
14	Phase IV Study of the Efficacy of Entecavir in Patients With Chronic Hepatitis B Virus Infection and Persistently Normal Alanine Aminotransferase	Unknown status	NCT01833611	Phase 4	Entecavir;placebo
15	Efficacy and Safety of Combination Therapy With Entecavir, Peginterferon Alfa-2b and Immunomodulators in Nucleoside or Nucleotide Analogue (NA)-Suppressed Chronic Hepatitis B Patients	Unknown status	NCT03332329	Phase 4	Entecavir;Granulocyte Macrophage Colony Stimulating Factor;Y peginterferon alfa-2b;HBV vaccine
16	Influence of Antiviral Treatment to the Long-Term Prognosis of Patients With Chronic HBV Infection.	Unknown status	NCT00810524	Phase 4	lamivudine;Telbivudine;Enticavir;Adefovir Dipivoxil Tablets
17	Randomized, Multicenter, Open -Label Clinical Trial to Study the Effect of Adding on Pegylated Interferon Therapy for Patients Diagnosed With Chronic Hepatitis B Showing Maintained Response While Receiving Ongoing Nucleotide Analogues	Unknown status	NCT02982837	Phase 4	PEG-IFN & Nucleos(t)tide analogues;Nucleos(t)tide analogues
18	The Optimizing Treatment of Peginterferon Alpha in Chronic Hepatitis B Patients With Low Level HBsAg(I-Cure-3X)	Unknown status	NCT03801538	Phase 4	Peginterferon Alfa;Nucleoside Analog (Substance)
19	Sustained Off-treatment Response After HBeAg Loss in HBeAg-Pos Chronic Hepatitis B Patients Treated With Nucleos(t)Ide Analogues	Unknown status	NCT01911156	Phase 4	Continue NA treatment;Discontinue NA Treatment
20	A Randomized, Open Label, Phase IV, Multicenter Study for Efficacy and Safety of Lamivudine Versus Entecarvir Therapy in HBV-related Advanced Liver Disease Patients With High Viral Load and Normal or Slightly Elevated Transaminase	Unknown status	NCT00823550	Phase 4	Entecavir;Lamivudine
21	A Randomized, Double Blind Controlled Trial to Evaluate the Therapeutic Effect of Telbivudine With or Without Prednisolone Priming in Patients With Chronic Hepatitis B	Unknown status	NCT00778596	Phase 4	Prednisolone;Placebo priming
22	Investigation on Antiviral Therapy of Peginterferon Alfa-2b in HBeAg Positive Chronic Hepatitis B Patients Based on Detection of Interferon Gene Mutation and Interferon Receptor	Unknown status	NCT02973646	Phase 4	Entecavir or Tenofovir;Peginterferon Alfa-2B
23	A Real-World Study of Sequential Combination Therapy With Pegylated Interferon In Nucleoside-treated Patients With Chronic Hepatitis B	Unknown status	NCT03357822	Phase 4	Pegylated interferon;Entecavir;Tenofovir disoproxil fumarate
24	The Optimizing Treatment of PegIFN Alfa in HBeAg-negative Chronic Hepatitis B Patients With Low Level HBsAg	Unknown status	NCT02745704	Phase 4	Peginterferon alfa
25	Active Drug Comparative Trial to Evaluate the Antiviral Activity and Safety in Chronic Hepatitis B Patients	Unknown status	NCT02588937	Phase 4	EntecaBell ODT. 0.5mg;Baraclude Tab. 0.5mg
26	A Prospective, Randomized, Multicenter, Open-label, Exploratory Study of Utilizing of "Response-Guided-Therapy (RGT)" Strategy on Optimal Nucleoside Analogue (NUC)-Experienced Patients	Unknown status	NCT02560649	Phase 4	Peginterferon alfa-2a plus Entecavir;Peginterferon alfa-2a plus Lamivudine;Peginterferon alfa-2a plus Adefovir;Peginterferon alfa-2a plus Tenofovir;Entecavir;Lamivudine;Adefovir;Tenofovir disoproxil
27	Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis	Unknown status	NCT01998620	Phase 4	Ademetionine 2;Ademetionine 1;Ademetionine 3
28	Open Label Study of Nucleus(t)Ide Treated Patients Randomised to Tenofovir, or Tenofovir + Telbivudine	Unknown status	NCT02774837	Phase 4	Tenofovir disoproxil;Telbivudine
29	A Pilot Study to Evaluate the Efficacy and Safety of Pegylated Interferon Alfa-2b Plus Ribavirin in the Treatment of Patients With Dual Chronic Hepatitis B and Delta	Unknown status	NCT00117533	Phase 4	pegylated IFN alfa-2b plus ribavirin
30	Randomized Study Comparing Nucleoside Analogues Plus Tenofovir and Nucleoside Analogues Plus Adefovir in Chronic Hepatitis B Patients With Suboptimal Response to Adefovir-based Combination Therapy Due to Nucleoside Analogues Resistance	Unknown status	NCT01595633	Phase 4	Switching from adefovir (10mg/day) to tenofovir (300mg/day)
31	A Study of Efficacy and Safety of Telbivudine in Pregnancy for the Prevention of Perinatal Transmission of Hepatitis B Virus Infection	Unknown status	NCT00939068	Phase 4	Telbivudine
32	A Prospective, Open-label, Multicenter Study of Lamivudine Extending Therapy in Chronic Hepatitis B Patients After 3-year of Oral Antiviral Agents	Unknown status	NCT02337127	Phase 4	Lamivudine
33	Emtricitabine for Prevention of Vertical Transmission of HBV in Chinese Pregnant HBsAg Positive Patients	Unknown status	NCT02327715	Phase 4	Emtricitabine
34	The Changes of CD8+T Cells Frequency and Function During Pegylated Interferon α-2a and Nucleoside Analogues Treatment in Patients With Chronic Hepatitis B	Unknown status	NCT03209037	Phase 4	Peginterferon Alfa-2a
35	Pilot Study to Assess the Antiviral Activity and Safety of Besifovir Dipivoxil 150mg and L-carnitine 660mg Compared to Tenofovir Alafenamide 25mg in Chronic Hepatitis B Patients With Nonalcoholic Fatty Liver	Unknown status	NCT03604016	Phase 4	Besifovir dipivoxil;L-carnitine;Tenofovir Alafenamide
36	Influence of Hepatic Steatosis on the Therapeutic Effect of Entecavir in Chronic Hepatitis B Patients-A Randomized, Double-Blinded, Controlled Trial	Unknown status	NCT01148576	Phase 4	entecavir;essentiale + entecavir;Vitamin E + entecavir
37	Efficacy of Long-term Telbivudine Treatment on Histological Improvements in Patients With Chronic Hepatitis B (EFFORT Further Extension Study)	Unknown status	NCT02826070	Phase 4	Telbivudine;Adefovir dipivoxil
38	Pegasys Plus Entecavir Versus Entecavir Alone for Hepatitis Be Antigen-Positive Chronic Hepatitis B	Unknown status	NCT00597259	Phase 4	Pegasys plus Entecavir;Entecavir
39	A Multicenter, Open-label, Prospective Study to Evaluate Antiviral Efficacy and Safety of Entecavir Plus Tenofovir Combination in Subjects With Multi-drug Resistant Chronic Hepatitis B Virus Infection	Unknown status	NCT01594905	Phase 4	Entecavir + Tenofovir (MDR group)
40	Efficacies of Entecavir Add on HBeAg Negative Chronic Hepatitis B Patients With HBV DNA Load ≥1000 Copies/ml After 3 Months of Peginterferon Alpha 2a Treatment	Unknown status	NCT02365402	Phase 4	Entecavir
41	An Open-label Rollover Study in Chinese Patients After Finishing a 3-year Randomize Trial for Chronic Hepatitis B With High Serum Viral Load But Mild Elevated Aminotransferase	Unknown status	NCT02463019	Phase 4	Tenofovir Disoproxil Fumarate
42	Efficacies of Entecavir Add on Chronic Hepatitis B Patients With HBV DNA Load ≥1000 Copies/ml After 6 Months Treatment of Peginterferon Alpha 2a	Unknown status	NCT02368288	Phase 4	entecavir
43	Emtricitabine for Naive Chinese Pregnant Chronic Hepatitis B Patients	Unknown status	NCT02327702	Phase 4	Emtricitabine
44	Emtricitabine Plus Adefovir Dipivoxil for Naive Chinese HBV Related Cirrhosis Patients	Unknown status	NCT02327689	Phase 4	Emtricitabine plus adefovir dipivoxil
45	Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients	Unknown status	NCT02327676	Phase 4	Emtricitabine
46	Emtricitabine for Naive Chinese Chronic Hepatitis B Patients	Unknown status	NCT02327663	Phase 4	Emtricitabine
47	A Prospective, Randomized, Multicenter, Open-label Study Evaluating HBeAg Seroconversion in HBeAg Positive CHB Patients on Treatment With NA Switched to Combined Therapy With Peginterferon Alfa-2a and NA for 48 Weeks	Unknown status	NCT02474316	Phase 4	Peginterferon alfa-2a;nucleos(t)ide analgoue
48	Entecavir and Peginterferon Alfa-2a Sequential Therapy Versus Peginterferon Alfa-2a Monotherapy for HBeAg Positive Chronic Hepatitis B	Unknown status	NCT00921180	Phase 4	Entecavir and peginterferon alfa-2a;Placebo and peginterferon
49	HBsAg Clearance of Peginterferon Treatment in Patients Who Had Chronic Hepatitis B and Were on the Treatment of Nucleoside(Acid) Analogues	Unknown status	NCT02362490	Phase 4	peginterferon alpha 2a
50	A Prospective, Randomized, Multicenter, Open-label, Exploratory Study of Utilizing of Peginterferon Alfa-2a on the Relapse Rate of the Subjects With Hepatocellular Carcinoma Who Have Been Treated by Resection	Unknown status	NCT03253250	Phase 4	ETV；TDF；ADV;Peginterferon Alfa-2a

Search NIH Clinical Center for Hepatitis B

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

adefovir

adefovir dipivoxil

entecavir

Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]

Interferon Alfa-2b

Lamivudine

telbivudine

Tenofovir

tenofovir alafenamide fumarate

Tenofovir disoproxil fumarate

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Hepatitis B cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Hepatitis B:

Bone marrow-derived mesenchymal stem cells for treatment of liver failure

Embryonic/Adult Cultured Cells Related to Hepatitis B:

Bone marrow-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: hepatitis b

Sources

Genetic Tests for Hepatitis B

Sources

Anatomical Context for Hepatitis B

Organs/tissues related to Hepatitis B:

FMA: Liver

MalaCards : Liver, Kidney, T Cells, Bone Marrow, Skin, Placenta, Bone

Sources

Publications for Hepatitis B

Articles related to Hepatitis B:

(show top 50) (show all 42147)

#	Title	Authors	PMID	Year
1	A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. ⁵³ ⁶² ⁵	Zhou J...Zheng BJ	19488747	2009
2	Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. ⁶² ⁵	Frodsham AJ...Hill AV	16757563	2006
3	Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. ⁵	Cooke GS...Hill AV	16690980	2006
4	Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection. ⁵	Thye T...Horstmann RD	12516030	2003
5	Hepatitis B and C viral coinfections and their association with HIV viral load suppression among HIV-1 infected patients on ART at Mekelle hospital, northern Ethiopia. ⁴¹	Teame G...Adane K	36457041	2022
6	Healthcare-associated hepatitis B and C transmission to patients in the EU/EEA and UK: a systematic review of reported outbreaks between 2006 and 2021. ⁴¹	Singh J...Duffell E	36463162	2022
7	Hepatitis B functional cure and immune response. ⁴¹	Zheng JR...Feng B	36466821	2022
8	Plasma levels of trace elements have an implication on interferon treatment of children with chronic hepatitis B infection. ⁵³ ⁶²	Balamtekin N...Ozcan O	19727570	2010
9	T29C genotype polymorphism of estrogen receptor alpha is associated with initial response to interferon-alpha therapy in chronic hepatitis B patients. ⁵³ ⁶²	Zhang TT...Li X	20525555	2010
10	Effect of maternal hepatitis B carrier status on first-trimester markers of Down syndrome. ⁵³ ⁶²	Cheng PJ...Hsieh TT	20332164	2010
11	Viral hepatitis and inflammatory bowel disease. ⁵³ ⁶²	Hou JK...Mahadevan U	20480515	2010
12	Level of hepatitis B virus DNA in inactive carriers with persistently normal levels of alanine aminotransferase. ⁵³ ⁶²	Chu CM...Liaw YF	20304099	2010
13	Differential transcriptional responses to interferon-alpha and interferon-gamma in primary human hepatocytes. ⁵³ ⁶²	He XS...Liang TJ	20038212	2010
14	Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus. ⁵³ ⁶²	Wang YP...Jiang JD	20176893	2010
15	Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene. ⁵³ ⁶²	Cohen D...Shaul Y	20155784	2010
16	Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. ⁵³ ⁶²	Zhang F...Zhang X	20419804	2010
17	Should antiviral treatment be extended to patients with chronic hepatitis B and mildly elevated alanine aminotransferase? ⁵³ ⁶²	Lok AS	20162620	2010
18	Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. ⁵³ ⁶²	Zhou Y...Huang B	20164184	2010
19	Comparison between quantitative hepatitis B surface antigen, hepatitis B e-antigen and hepatitis B virus DNA levels for predicting virological response to pegylated interferon-alpha-2b therapy in hepatitis B e-antigen-positive chronic hepatitis B. ⁵³ ⁶²	Tangkijvanich P...Poovorawan Y	20070399	2010
20	Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase. ⁵³ ⁶²	Liu H...Ma C	20107884	2010
21	Efficacy of entecavir in chronic hepatitis B patients with mildly elevated alanine aminotransferase and biopsy-proven histological damage. ⁵³ ⁶²	Wu IC...Chang TT	20044806	2010
22	Influence of transforming growth factor-beta1 gene polymorphism at codon 10 on the development of cirrhosis in chronic hepatitis B virus carriers. ⁵³ ⁶²	Yu SK...Kim JH	20357999	2010
23	Early viral kinetics of telbivudine and entecavir: results of a 12-week randomized exploratory study with patients with HBeAg-positive chronic hepatitis B. ⁵³ ⁶²	Suh DJ...Zeuzem S	20028815	2010
24	Inhibition of STAT1 methylation is involved in the resistance of hepatitis B virus to Interferon alpha. ⁵³ ⁶²	Li J...Chen Z	19857525	2010
25	Antiviral activity and safety of LB80380 in hepatitis B e antigen-positive chronic hepatitis B patients with lamivudine-resistant disease. ⁵³ ⁶²	Yuen MF...Lai CL	20091678	2010
26	The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication. ⁵³ ⁶²	Gearhart TL...Bouchard MJ	20053744	2010
27	A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B. ⁵³ ⁶²	Tan AT...Bertoletti A	20137825	2010
28	Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator. ⁵³ ⁶²	Bui-Nguyen TM...Kumar R	20022949	2010
29	Prevalence and risk factors of focal sparing in hepatic steatosis. ⁵³ ⁶²	Kratzer W...Haenle MM	20157869	2010
30	Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review. ⁵³ ⁶²	Zhang L...Bonkovsky HL	20101751	2010
31	Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis B. ⁵³ ⁶²	Lee HW...Han KH	19902424	2010
32	NF-kappaB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx. ⁵³ ⁶²	Bui-Nguyen TM...Kumar R	20010875	2010
33	Long-term efficacy of interferon alpha therapy on hepatitis B viral replication in patients with chronic hepatitis B: a meta-analysis. ⁵³ ⁶²	Yang YF...Wen J	19900483	2010
34	The hepatitis B viral X protein activates NF-kappaB signaling pathway through the up-regulation of TBK1. ⁵³ ⁶²	Kim HR...Jung G	19958770	2010
35	A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. ⁵³ ⁶²	Wang Q...Zhang X	20126469	2010
36	Circulating CD4+CD25high regulatory T cells and expression of PD-1 and BTLA on CD4+ T cells in patients with chronic hepatitis B virus infection. ⁵³ ⁶²	Nan XP...Bai XF	20121403	2010
37	Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation. ⁵³ ⁶²	Kim YJ...Jang KL	19656618	2010
38	Hepatitis B viral X protein alters the biological features and expressions of DNA repair enzymes in LO2 cells. ⁵³ ⁶²	Cheng B...Liu C	19968784	2010
39	Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment. ⁵³ ⁶²	Kobayashi M...Kumada H	19788696	2010
40	Adefovir plus lamivudine are more effective than adefovir alone in lamivudine-resistant HBeAg- chronic hepatitis B patients: a 4-year study. ⁵³ ⁶²	Vassiliadis TG...Eugenidis N	19780875	2010
41	How can we enhance the performance of liver stiffness measurement using FibroScan in diagnosing liver cirrhosis in patients with chronic hepatitis B? ⁵³ ⁶²	Kim SU...Han KH	19609218	2010
42	Extended lamivudine consolidation therapy in hepatitis B e antigen-positive chronic hepatitis B patients improves sustained hepatitis B e antigen seroconversion. ⁵³ ⁶²	Kuo YH...Lee CM	20030580	2010
43	Occult hepatitis B virus infection: a covert operation. ⁵³ ⁶²	Hollinger FB...Sood G	20002296	2010
44	Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice. ⁵³ ⁶²	Hiraga N...Chayama K	19853955	2009
45	Distinct regulation of hepatitis B virus biosynthesis by peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner in human hepatoma cell lines. ⁵³ ⁶²	Ondracek CR...McLachlan A	19793803	2009
46	Impaired TLR3/IFN-beta signaling in monocyte-derived dendritic cells from patients with acute-on-chronic hepatitis B liver failure: relevance to the severity of liver damage. ⁵³ ⁶²	Li N...Shi G	19833099	2009
47	Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis. ⁵³ ⁶²	Ondracek CR...McLachlan A	19793822	2009
48	Nutritional status of children with chronic hepatitis B in a population with low socioeconomic status. ⁵³ ⁶²	Bekem Soylu O...Ortac R	19458532	2009
49	Abnormal liver function test results are related to metabolic syndrome and BMI in Taiwanese adults without chronic hepatitis B or C. ⁵³ ⁶²	Hsieh MH...Yu ML	19752878	2009
50	IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. ⁵³ ⁶²	He Y...Cao G	19797428	2009

Sources

Genes for Hepatitis B

Genes related to Hepatitis B (0 elite genes):

(show top 50) (show all 66)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MIR21	MicroRNA 21	RNA Gene	67.67	Unspecified ⁴⁶ DISEASES inferred ¹⁴ ¹⁴ GeneCards inferred via : Publications (show sections)	18223217
2	MIR17	MicroRNA 17	RNA Gene	66.69	Unspecified ⁴⁶ DISEASES inferred ¹⁴ ¹⁴ GeneCards inferred via : Publications (show sections)	18223217
3	RSF1	Remodeling And Spacing Factor 1	Protein Coding	62.73	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Gene name Summaries Functions (show sections)	19263472 16677157 11278765 (more) 16169872 17187364 19958770 16984372 11522297 16173017 9223516 12011457 8134379 20155784 20126469 12878326 10656696 10101251 9837906 16937438 12538486 14724286 12625370 10501507 19671315 19343061 16461023 11377708 10833446 9195957 19968784 16219135 17484888 15949399 14662947 19367718 15142444 15107488 11692143 9420223 9385399 8972861 1309924 20419804 18465238 17575144 11527698 20107884 16135253 8607273 9638654 10051498 12854155 18264140 9819395 9405677 8774700 8663128 2196386 2154703 20053744 19746176 18449922 1327450 19208517 17408664 17309779 16920820 15450428 14680837 10516464 16515689 16274670 16863502 16554914 12242658 11756437 11244564 10684300 10679226 7815490 7842349 8116251 1360668 19656618 19105208 15078869 15108328 15068583 14575563 12599056 11732012 11700033 11125170 10559358 7828586 10402250 9755238 9511751 8521397
4	LAMTOR5	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5	Protein Coding	61.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Gene name Summaries Proteins Functions (show sections)	17303008 16982752 19885569 (more) 18158869 12773388 18822201 11925594
5	MIR301A	MicroRNA 301a	RNA Gene	53.78	Unspecified ⁴⁶ DISEASES inferred ¹⁴	18223217
6	IFNA1	Interferon Alpha 1	Protein Coding	48.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	10706563 15951551 10760045 (more) 18019713 12734046 11693335 10435653 17958644 15853986 9097274 11576461 10845671 2242614 9339942 11703575 15759817 12447867 11782925 12589849 15209626 7655700 7666040 8903365 8995939 10897000 12481401 15588803 15163392 1629752 2312667 18494055 17607775 17397939 16846649 17153763 17107734 16225956 15926860 15610453 15230858 12198608 11944697 11526544 11380796 11170061 11038017 9857350 9563957 10322827 9718855 9396177 9024450 8871871 7590646 19103527 19210112 18950714 17922996 17191307 16920161 16498343 16218171 15185972 14654974 10229237 9665354 9500721 9407357 9324188 9093946 8871872 7529950 8082512 7694426 1571575 1562748 1312844 2050997 20101751 19853955 12931030 11482999 11434628 11354277 11273498 10349692 10847132 10030109 18310963 17716343 18021533 17237999 17204960 17133492 16828170 16249973 10607253 9951916 9126787 11983129 16171525 16118673 10462338 16552819 10385662 15998426 16012762 9604791 15720536 17907286 12540064 9352870 16437668 15324946 15041897 12139566 7557846 19220736 8509639 11464426 9581701 12447724 15799171 12639168 8645511 19669298 19100228 18504225 11431745 10655277 9195365 17407708 16554704 11855559 11208440 10764718 1279242 17065208 16557544 11124848 17892402 15340535 10847482 8844478 20525555 17627635 15571480 12773249 12702905 12226832 9658370 17374576 8871880 16733849 1680935 7514058 7740291 10385667 11225393 20137825 19714778 19579727 15610309 12921298 8607568 7515733 1415022 20038212 19727570 17619534 17396441 17075991 16448447 1600196 1577226 1715348 19900483 18410608 17244247
7	IFNA2	Interferon Alpha 2	Protein Coding	45.49	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	7702228 2031078 8586031 (more) 8790569 2186494 20032548 8460337 16611278 1448711 2181991 9402109 9689164 12820143 15854180 19583877 16721856 14696459 7876462 7998397 7694426 8509638 1614804 2090770 19931086 9212590 9055880 8942117 8006396 8160137 16771948 8711248 8045488 2067345 15565603 15209626 9239783 8947886 8745316 7536374 8507888 1699825 2201157 16975352 16629642 15007744 11350695 9339942 9298736 19043923 16557544 10944819 8625380 8580274 2117831 2357834 17243057 16964669 1629752 16649370 16846649 7912504 20070399 2178900 11517899 12508364 9857348 9412946 10643851 11592603 17125604 17429526 15757824 16640106 1841409 9829853 16416004 16775956 2288653 8657367 18672534 17244247 8645511 17717966 17468063 15230858 12823597 9684137 7716906 1779715 1660965 18069753 15078472 11422784 12875729 8133104 1825307 19653058 17532587 16554704 12010505 11399862 10849265 9097275 8927872 8616681 7636501 7930473 8160138 8308214 1450701 1998314 17073632 15334319 11208440 10365576 7472844 8335309 2258142 19100234 18698691 16944240 16732903 16225048 16201464 15040533 12195876 11100350 11284252 10063307 10028858 9763845 8852910 8082511 8509640 7687978 16941701 12802750 12921298
8	SLC10A1	Solute Carrier Family 10 Member 1	Protein Coding	45.37	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
9	NR5A2	Nuclear Receptor Subfamily 5 Group A Member 2	Protein Coding	45.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Gene name Summaries Functions (show sections)	11595170 12800251 10627534 (more) 14515208 16039139 9786908
10	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	42.23	Novoseek inferred ⁵³ GeneCards inferred via : Publications Gene name Summaries Functions (show sections)	14730974 9447995 10777214 (more) 11955954 16101299 19113837 8972861 11093792
11	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	41.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20028815 8243482 10192613 (more) 12584227 16460486 2321585 2379783 16042881 9138277 17935720 20304099 7940658 2319401 8241932 1681620 8424423 7509301 7528172 7542359 9118030 11379338 12410483 18030234 16928217 16107194 15646431 15369508 14638403 14533986 12879950 12447724 7978047 8129787 7509088 1383416 1747001 1656553 2242718 20091678 19674287 19585616 19704174 18840078 12472960 18094378 17606962 17196132 16987866 16921743 12368144 11982720 11642634 11472586 11073757 10707871 10397080 9654535 9570237 7584778 20002296 19458532 19704171 19179968 19210112 19052126 18830542 18088241 8943974 17999990 17876546 16378277 16729316 15387343 15221894 15086598 12668966 9407645 9218853 9010649 8314468 1908889 19780875 19788696 19902424 16038760 16091060 15500383 14960533 9857348 9527418 8938538 7865717 20030580 19669296 19226381 19430095 18931274 18771054 18370481 19032864 12828081 8507764 19208347 18600393 20044806 18359663 19752878 15858291 18234638 19812443 11951067 19235869 16394850 15185315 15016922 11679974 17701844 8844478 16925509 15788985 18721244 12235465 15336449 12536496 11207658 8727711 7751585 8049886 19293791 19609218 19554656 19468026 18673426 12768389 20162620 19669302 19578234 19334384 18492018 18537189 18410611 16525138 15710957 15192799 14655057 20480515 17121706 12606735
12	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	41.14	Risk factor ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16757563 11170061 9195405
13	APOBEC3G	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3G	Protein Coding	38.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Proteins Functions (show sections)	17167839 18420796 18336343 (more) 18806783 16426578 18849968
14	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	38.38	Risk factor ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	16757563
15	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	38.3	Risk factor ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	12516030 16690980 19488747
16	CPD	Carboxypeptidase D	Protein Coding	37.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries Functions (show sections)	9714835 9525948 9064476 (more) 11602705 10482623
17	DDB1	Damage Specific DNA Binding Protein 1	Protein Coding	36.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)	9020796 9740790
18	AFP	Alpha Fetoprotein	Protein Coding	34.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19785836 1381228 10967924 (more) 10967973 9328161 11506304 16143073 18839035 16451784 12143050 10082044 7527585 12203078 17132920 18971167 11026763 15086601 1384940 16436007 17374575 9118030 11379338 11857416 12595051 15949354 16713550 16928217 17370144 18823435 20206885 7743468 1694150 1712517 1715897 9661742 19197197 18482268 18156768 16437617 15305374 15049804 8672950 7525036 15983686 16172579 14737946 8764540 8875621 8640025 17767898 17214153 12618900 1285320 1722452 17111729 10433023 1713804 1704292 19453644 14675261 8792309 7536406 7519505 1688400 20207771 17637219 11758193 11129271 10347111 1690841 17465484 11376383 11891535 17059345
19	F2	Coagulation Factor II, Thrombin	Protein Coding	31.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14980106 8175127 10664223 (more) 1449004 11443618 14688451 10670643 12522534 18598280 19192404 7867249 14564632 16127523 1875066 17653310 10606325
20	ALB	Albumin	Protein Coding	31.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12003380 8666314 19785947 (more) 17666340 1447497 14980106 18822893 1693509 7541203 7557853 16556409 17971944 20104760 1734496 11270948 11856505 10341335 1846342 8511892 1690841 9756468 2103380 12668133 2373467 1751102 11068987 14633666 1708367 8129787 9646223 12442396 8476506 20056985 17211710 16482557 16024289 12558746 12199524 12005245 14570603 11746539 10975305 18482268 8865927 1688735 20037266 18947029 17470300 16855416 12004342 9537435 9430355 1730154 15857960 12618900 7510478 18662281 19237903 16127523 17520570 12522534 9597257 19458532 18830542 18637057 14688451 11443618 12442373 7690344 20104784 18394943 12828087 1323561 10503083
21	PTMA	Prothymosin Alpha	Protein Coding	30.95	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15946554 17075991 9007707 (more) 12820143 8855175 19467157 15849818 19802821 9728561 17109685 11798819 10759236 16416004 14606705 16640105 10607256 18078676 15546254 18221304 16608033 15850471 9581695 18410608 8871880 10921382 10027483 15759817 15340532 1874487 15641208 1810323
22	IFNG	Interferon Gamma	Protein Coding	30.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2115494 1959885 1430105 (more) 2145212 8551280 12297850 7685809 1761362 16302211 15813485 1906436 11589367 8315260 16953839 1641292 9014013 10554120 12534946 9096614 8706330 8743107 1808224 1704230 1707382 17475895 16232344 15376464 9525579 19773191 19488747 17381719 16642215 16250037 15265425 12477411 11576883 16718779 15963597 14673494 11991993 11115698 8978359 8259703 8258624 1384110 18313151 17845304 17033822 16718780 2115499 18633332 18442200 17711903 11738107 9862872 17886224 16944293 15940636 15929178 15781128 15368520 14769147 12794718 11798769 9806046 11012627 8273806 2121769 16227262 14602204 11780382 11410875 10795772 11236507 19099815 12414777 10638591 12296860 17202217 20021848 11983129 10938594 1940881 2106474 9537868 7774054 11819731 7516948 11676870 1919540 1902879 9951911 12174378 7596091 19335978 16234012 11940380 10331564 7927247 12772056 17657819 11169072 10497102 8152201 1899851 12716531 7587774 12899793 15182648 2118117 20038212 16052691
23	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	30.58	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
24	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	30.41	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
25	ASGR2	Asialoglycoprotein Receptor 2	Protein Coding	30.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	8590155 10891274 7964611
26	DDX3X	DEAD-Box Helicase 3 X-Linked	Protein Coding	30.09	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
27	RARB	Retinoic Acid Receptor Beta	Protein Coding	30	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Gene name Summaries (show sections)
28	MRC1	Mannose Receptor C-Type 1	Protein Coding	29.73	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins Functions (show sections)
29	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	29.73	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries Proteins (show sections)
30	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	29.67	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	16916662 15231205 12778456 (more) 11318984 17990456 17370149
31	MBL2	Mannose Binding Lectin 2	Protein Coding	29.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Functions (show sections)	15716605 18543229 10094971 (more) 9519208 14723627 11063157 12517417 11906616 18592362 9813410 8965590 8937276
32	SON	SON DNA And RNA Binding Protein	Protein Coding	28.41	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries Functions (show sections)
33	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	28.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15997630 18322611 11276277 (more) 19752878 18843956 11983131 12873819 8732872 11811111 15369508 16104652 16921743 15993394 19458532 1975706 11395693 18482268 19203448 15670483 1931729 8628133 17250612 18988716
34	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	28.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19469173 14567092 16808311 (more) 15011870 15309715 8510488 16440431 14593968 19169878 17456311 15099471 20357999 15377291 12858019
35	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	27.56	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8138256 8129787 9821088 (more) 12005245 15881863 16921743 17917635 19334390 9211210 9218853 11073757 15993394 19149648 2342668 9272578 9439157 11684554 12025049 7618165 15633260 16861097 17535046 18180838 19669268 1355950 15306699 18482268 19773278 18988716 17250612 11233898 10433578 8943756 8457958 7557098 10760045 14504367 19291350 9886109 17654317 19674763 8237937 18025069 19752878 20157869 11589765 19785947 19858600 15976740 18822893 15997630 15485795 16556409 18322611 12499816
36	TLR4	Toll Like Receptor 4	Protein Coding	27.32	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	17524268 16253129 18565796 (more) 17187404
37	TNF	Tumor Necrosis Factor	Protein Coding	27.11	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)
38	ASGR1	Asialoglycoprotein Receptor 1	Protein Coding	27.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	16475991
39	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	26.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	17237271
40	TLR2	Toll Like Receptor 2	Protein Coding	26.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	17524268 16894001 18983769 (more) 17187404 19811087
41	TLR3	Toll Like Receptor 3	Protein Coding	26.71	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19833099
42	IL6	Interleukin 6	Protein Coding	26.35	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)
43	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	26.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	16394798 19857525
44	HVBS7	Hepatitis B Virus Integration Site 7	Uncategorized	26.02	GeneCards inferred via : Publications Gene name Functions (show sections)
45	HVBS8	Hepatitis B Virus Integration Site 8	Uncategorized	25.84	GeneCards inferred via : Publications Gene name Functions (show sections)
46	FGL2	Fibrinogen Like 2	Protein Coding	25.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16437596 18801734 15268797 (more) 12840059
47	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	24.93	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	18971270
48	IFNB1	Interferon Beta 1	Protein Coding	24.52	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)
49	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	24.32	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)
50	RBCK1	RANBP2-Type And C3HC4-Type Zinc Finger Containing 1	Protein Coding	24.2	GeneCards inferred via : Publications Gene name Proteins (show sections)

Sources

Variations for Hepatitis B

ClinVar genetic disease variations for Hepatitis B:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	IFNGR1	NM_000416.3(IFNGR1):c.-56T>C	SNV	Risk Factor	355565	rs2234711	GRCh37: 6:137540520-137540520 GRCh38: 6:137219383-137219383
2	IFNAR2	NM_001289125.3(IFNAR2):c.23T>C (p.Phe8Ser)	SNV	Risk Factor	7288	rs2229207	GRCh37: 21:34614250-34614250 GRCh38: 21:33241945-33241945
3	IL10RB	NM_000628.5(IL10RB):c.139A>G (p.Lys47Glu)	SNV	Risk Factor	16923	rs2834167	GRCh37: 21:34640788-34640788 GRCh38: 21:33268483-33268483
4	IFNAR2	NM_001289125.3(IFNAR2):c.505G>A (p.Val169Ile)	SNV	Uncertain Significance	1673082		GRCh37: 21:34621124-34621124 GRCh38: 21:33248819-33248819
5	IFNGR1	NM_000416.3(IFNGR1):c.974C>T (p.Pro325Leu)	SNV	Uncertain Significance	992563	rs753495798	GRCh37: 6:137519664-137519664 GRCh38: 6:137198527-137198527

Sources

Expression for Hepatitis B

Search GEO for disease gene expression data for Hepatitis B.

Sources

Pathways for Hepatitis B

Pathways related to Hepatitis B according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.38	SLC10A1 IFNAR2 IFNA2 IFNA1 DDB1
2	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.27	IL10RB IFNGR1 IFNAR2 IFNA2 IFNA1
3	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.19	IFNGR1 IFNAR2 IFNA2 IFNA1
4	Host-pathogen interaction of human coronaviruses - interferon induction ⁷⁴ Show member pathways Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶⁰ SARS coronavirus and innate immunity ⁷⁴ Type I interferon induction and signaling during SARS-CoV-2 infection ⁷⁴	11.48	IL10RB IFNAR2 IFNA2
5	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.04	IFNGR1 IFNAR2 IFNA2
6	Interferon Pathway ⁶⁴	10.88	IFNGR1 IFNAR2 IFNA2 IFNA1
7	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	10.77	F2 ALB AFP

Sources

GO Terms for Hepatitis B

Cellular components related to Hepatitis B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.6	MIR301A MIR21 MIR17 IFNAR2 IFNA2 IFNA1

Biological processes related to Hepatitis B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	type I interferon-mediated signaling pathway	GO:0060337	9.85	IFNAR2 IFNA2 IFNA1
2	defense response to virus	GO:0051607	9.85	APOBEC3G IFNA1 IFNA2 IFNAR2 IL10RB
3	cytokine-mediated signaling pathway	GO:0019221	9.65	IL10RB IFNGR1 IFNAR2 IFNA2 IFNA1
4	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.58	MIR301A MIR21 MIR17
5	cellular response to virus	GO:0098586	9.36	MIR21 IL10RB IFNGR1 IFNAR2 IFNA2 IFNA1
6	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.32	MIR21 MIR17
7	positive regulation of metalloendopeptidase activity	GO:1904685	9.26	MIR21 MIR17