MCID: HPT007
MIFTS: 56

Hepatitis E

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Liver diseases, Rare diseases, Skin diseases

Aliases & Classifications for Hepatitis E

MalaCards integrated aliases for Hepatitis E:

Name: Hepatitis E 12 76 53 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4411
MeSH 44 D016751
UMLS 73 C0085293

Summaries for Hepatitis E

Disease Ontology : 12 A viral infectious disease that results in inflammation located in liver, has material basis in Hepatitis E virus, which is transmitted by ingestion of contaminated food. The infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom dark urine, has symptom joint pain, and has symptom jaundice.

MalaCards based summary : Hepatitis E is related to viral infectious disease and acute liver failure, and has symptoms including fever, vomiting and fatigue. An important gene associated with Hepatitis E is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and TRAF Pathway. The drugs Aluminum sulfate and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and testes, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 76 Hepatitis E is inflammation of the liver caused by infection with the hepatitis E virus. It is one of... more...

Related Diseases for Hepatitis E

Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis a
Hepatitis C Viral Hepatitis
Hepatitis D Hepatitis E

Diseases related to Hepatitis E via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 30.8 CD40LG GPT IFNG TLR3 TNF
2 acute liver failure 30.7 ALB F2 GPT
3 infantile liver failure syndrome 1 30.7 ALB F2 GPT
4 viral hepatitis 30.4 ALB F2 GPT TNF
5 hepatitis a 30.3 ALB F2 GPT IFNG TNF
6 hepatitis b 30.0 ALB F2 GPT IFNG TNF
7 liver disease 29.9 ALB F2 GPT TNF
8 hepatitis c 29.8 GPT IFNG TLR3 TNF
9 cholecystitis 29.5 ALB F2 GPT
10 alcoholic hepatitis 29.5 ALB F2 GPT TNF
11 leptospirosis 29.4 F2 IFNG TNF
12 hepatitis d 29.4 F2 GPT
13 meningitis 29.4 ALB IFNG TNF
14 typhoid fever 29.2 ALB F2 IFNG TNF
15 schistosomiasis 29.0 ALB CD40LG F2 IFNG TNF
16 hepatitis 11.2
17 hepatoportal sclerosis 10.2 F2 GPT
18 antipyrine metabolism 10.2 ALB F2
19 non-a-e hepatitis 10.2 ALB F2
20 epstein-barr virus hepatitis 10.2 ALB F2
21 variola major 10.2 IFNG TLR3
22 guillain-barre syndrome 10.2
23 abdominal tuberculosis 10.1 ALB F2
24 amyotrophic neuralgia 10.1
25 staphylococcal toxic shock syndrome 10.1 IFNG TNF
26 marburg hemorrhagic fever 10.1 F2 TNF
27 autoimmune myocarditis 10.1 IFNG TNF
28 trichosporonosis 10.1 IFNG TNF
29 adult dermatomyositis 10.1 GPT TNF
30 chronic beryllium disease 10.1 IFNG TNF
31 african tick-bite fever 10.1 CD40LG IFNG
32 hepatic tuberculosis 10.1 ALB F2 GPT
33 kwashiorkor 10.1 ALB F2 GPT
34 hepatic coma 10.1 ALB F2 GPT
35 sporotrichosis 10.1 CD40LG IFNG
36 scleritis 10.1 IFNG TNF
37 choledocholithiasis 10.1 ALB F2 GPT
38 analbuminemia 10.1 ALB F2 GPT
39 cardiac sarcoidosis 10.1 IFNG TNF
40 bile duct disease 10.1 ALB F2 GPT
41 fascioliasis 10.1 ALB GPT IFNG
42 bilirubin metabolic disorder 10.1 ALB F2 GPT
43 opisthorchiasis 10.1 GPT TNF
44 nonalcoholic steatohepatitis 10.1 F2 GPT TNF
45 hypersplenism 10.1 ALB F2 IFNG
46 wilson disease 10.1 ALB F2 GPT
47 miliary tuberculosis 10.1 IFNG TNF
48 mucocutaneous leishmaniasis 10.1 TLR3 TNF
49 spotted fever 10.1 F2 IFNG TNF
50 clonorchiasis 10.0 IFNG TNF

Graphical network of the top 20 diseases related to Hepatitis E:



Diseases related to Hepatitis E

Symptoms & Phenotypes for Hepatitis E

Symptoms:

12
  • fever
  • vomiting
  • fatigue
  • abdominal pain
  • jaundice
  • nausea
  • joint pain
  • loss of appetite
  • clay-colored bowel movements
  • dark urine

MGI Mouse Phenotypes related to Hepatitis E:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 ALB AMBP CD40LG FGB GRB2 IFNG
2 digestive/alimentary MP:0005381 9.8 ALB F2 GRB2 IFNG TNF VPS4A
3 embryo MP:0005380 9.8 AMBP F2 GRB2 IFNG TNF TSG101
4 neoplasm MP:0002006 9.43 ALB GRB2 IFNG TLR3 TNF TSG101
5 reproductive system MP:0005389 9.23 AMBP CD40LG F2 FGB GRB2 IFNG

Drugs & Therapeutics for Hepatitis E

Drugs for Hepatitis E (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aluminum sulfate Approved Phase 4,Phase 3 10043-01-3
2
Aluminum hydroxide Approved, Investigational Phase 4,Phase 3 21645-51-2
3
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
4 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Antiviral Agents Phase 4,Phase 2,Not Applicable
7 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
8 Antimetabolites Phase 4,Phase 2
9
Nicotinamide Approved, Investigational Phase 2, Phase 3,Phase 3 98-92-0 936
10
Milk thistle Approved, Experimental, Investigational Phase 2, Phase 3 65666-07-1
11
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 59-43-8, 70-16-6 1130
12
Niacin Approved, Investigational, Nutraceutical Phase 2, Phase 3,Phase 3 59-67-6 938
13
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 83-88-5 493570
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
15 Antioxidants Phase 2, Phase 3
16 Vitamin B Complex Phase 2, Phase 3
17 Vitamin B3 Phase 2, Phase 3
18 Vitamins Phase 2, Phase 3
19 Vitamin B9 Phase 2, Phase 3
20 Protective Agents Phase 2, Phase 3
21 silymarin Phase 2, Phase 3
22 Folate Phase 2, Phase 3
23 Thiamin Phase 2, Phase 3
24 Vitamin B2 Phase 2, Phase 3
25 Trace Elements Phase 2, Phase 3
26 Nicotinic Acids Phase 2, Phase 3
27 Micronutrients Phase 2, Phase 3
28
Peginterferon alfa-2a Approved, Investigational Phase 2 198153-51-4 5360545
29
Entecavir Approved, Investigational Phase 2,Not Applicable 142217-69-4 153941
30
Sofosbuvir Approved Phase 2 1190307-88-0 45375808
31 Liver Extracts Phase 2,Phase 1
32 interferons Phase 2
33
Basiliximab Approved, Investigational Phase 1 152923-56-3, 179045-86-4
34
Tacrolimus Approved, Investigational Phase 1 104987-11-3 445643 439492
35 Immunosuppressive Agents Phase 1
36
Permethrin Approved, Investigational Not Applicable 52645-53-1 40326
37 Antibodies
38 Immunoglobulins

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 A Phase Ⅳ Clinical Trial of the Recombinant Hepatitis E Vaccine (Escherichia Coli)(the Chronic Hepatitis B Patients ) Completed NCT02964910 Phase 4
2 A Phase Ⅳ Clinical Trial of the Recombinant Hepatitis E Vaccine (Escherichia Coli) Completed NCT02417597 Phase 4
3 Phase Ⅳ Clinical Trial of Recombinant Hepatitis E Vaccine(Hecolin®) Completed NCT02189603 Phase 4
4 A Phase Ⅳ Clinical Trial of the Recombinant Hepatitis E Vaccine (Escherichia Coli)(Coadministration With Recombinant Hepatitis B Vaccine) Completed NCT02584543 Phase 4
5 Effectiveness Trial to Evaluate Protection of Pregnant Women by Hepatitis E Vaccine in Bangladesh. Recruiting NCT02759991 Phase 4 Hecolin;Hepa-B
6 A Study on the Recombinant Hepatitis E Vaccine (Escherichia Coli) (Accelerated Vaccination Schedule) Active, not recruiting NCT03168412 Phase 4
7 Ribavirin for Severe Acute and Chronic Hepatitis E Virus Infection. Terminated NCT02558114 Phase 4 Ribavirin
8 A Phase Ⅳ Clinical Trial of the Recombinant Hepatitis E Vaccine (Escherichia Coli)(the Lot Consistency Trial) Withdrawn NCT03365921 Phase 4
9 Clinical Trial of Recombinant Hepatitis E Vaccine Unknown status NCT01014845 Phase 3
10 Field Trial of Maternal Influenza Immunization in Asia Unknown status NCT01034254 Phase 3
11 Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent(Type 16/18 )Vaccine Active, not recruiting NCT01735006 Phase 3
12 Randomized Placebo-controlled Trial Evaluating the Safety and Efficacy of Silymarin Treatment in Patients With Acute Viral Hepatitis Terminated NCT00755950 Phase 2, Phase 3
13 A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus Unknown status NCT01698723 Phase 2 Ribavirin;Placebo
14 Dose Ranging Study of Pegylated Interferon Lambda in Patients With Hepatitis B and Positive for the Hepatitis B e Antigen Completed NCT01204762 Phase 2 pegIFN;pegIFNα-2a;PegIFN lambda;Entecavir
15 HepNet Pilot Trial: Multicenter Trial for the Treatment of Chronic Hepatitis E With Sofosbuvir (SofE) Active, not recruiting NCT03282474 Phase 2 Sofosbuvir
16 Immunogenicity Study of the Recombinant Human Papillomavirus Virus Type 6/11 Bivalent Vaccine Active, not recruiting NCT02710851 Phase 2
17 A Safety and Efficacy Study of the Hepatitis E Vaccine in Nepal. Withdrawn NCT00287469 Phase 2
18 A Clinical Trial to Evaluate a Recombinant Hepatitis E Vaccine in Healthy Adults Completed NCT02603055 Phase 1
19 Safety and Tolerance of Immunomodulating Therapy With Donor-specific MSC in Pediatric Living-Donor Liver Transplantation Recruiting NCT02957552 Phase 1
20 The Epidemiology of Hepatitis E Virus Infection in Israel and Potential Risk Factors Unknown status NCT02419625 Not Applicable
21 Epidemiological Study of Hepatitis E Virus in Maintenance Hemodialysis Patients Unknown status NCT02645955
22 Investigation of Endemic and Emerging Diseases in Populations of Homeless Households in Marseille. Unknown status NCT02819128 Not Applicable
23 Seroprevalence of Hepatitis E in HIV Positive Patients in Basque Country in 2016 (VIhVhEpb) Completed NCT02847507
24 Role of Cytokines in Hepatitis E Virus Infection During Pregnancy Completed NCT01062321
25 Host Responses in Kidney-transplant Recipients With Chronic Hepatitis E Virus Infection Completed NCT01090232 Not Applicable
26 Prevalence of Antibodies to Selected Porcine Viruses in Patients With Cystic Fibrosis Receiving Porcine-derived Pancreatic Enzyme Replacement Therapy Completed NCT01858519
27 Study of the Immunogenicity and Efficacy of HBsAg Vaccine in Combination With Standard Antiviral Therapy With HB110E Completed NCT01813487 Not Applicable HBsAg vaccine with Entecavir
28 Hepatitis E Virus Infection in Pediatric Transplantation, a Prevalence Study Recruiting NCT02809885 Not Applicable
29 Seroprevalence of Hepatitis E in People With an Organ Transplant Recruiting NCT02190253
30 Hepatitis E Infection : Emergence Mechanisms in North-Eastern France of Polymorphic Clinical Forms. Recruiting NCT03524014
31 Seroprevalence Hepatitis E Infection in Healthy Blood Donors Recruiting NCT03601221
32 HEV in Patients With Acute Non-A, Non-B, Non-C Hepatitis in Al-Rajhy University Hospital for Liver Not yet recruiting NCT03488589

Search NIH Clinical Center for Hepatitis E

Cochrane evidence based reviews: hepatitis e

Genetic Tests for Hepatitis E

Anatomical Context for Hepatitis E

MalaCards organs/tissues related to Hepatitis E:

41
Liver, Kidney, Testes, T Cells, Heart, Brain, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatitis E:

19
Liver

Publications for Hepatitis E

Articles related to Hepatitis E:

(show top 50) (show all 1655)
# Title Authors Year
1
Characterization of a quasi-enveloped, fast replicating hepevirus from fish and its use as hepatitis E virus surrogate. ( 30399394 )
2019
2
Evidence of hepatitis E virus infections among persons who use crack cocaine from the Midwest region of Brazil. ( 30133759 )
2019
3
Human hepatitis E virus circulation in Bulgaria: Deep Bayesian phylogenetic analysis for viral spread control in the country. ( 30168583 )
2019
4
Hepatitis E seroprevalence in the United States: Results for immunoglobulins IGG and IGM. ( 30168589 )
2019
5
Treating chronic hepatitis E: when is enough enough? ( 29391359 )
2018
6
Ribavirin in Acute Hepatitis E Infection in Patients with Gynecological Cancer: A Case Series. ( 29951369 )
2018
7
Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l. ( 29452164 )
2018
8
Origin and dispersal of Hepatitis E virus. ( 29410449 )
2018
9
Detection of Astrovirus, Rotavirus C, and Hepatitis E Viral RNA in Adult and Juvenile Farmed Mink (<i>Neovison vison</i>). ( 29974054 )
2018
10
First detection and molecular characterization of hepatitis E virus in water from wastewater treatment plants in Portugal. ( 29936796 )
2018
11
Hepatitis E virus in neurological disorders: a case of Parsonage-Turner syndrome. ( 29685043 )
2018
12
Adult-Onset Still Disease and Macrophage Activation Syndrome Following Chikungunya and Hepatitis E Coinfection. ( 29485548 )
2018
13
The identification and characterization of novel rat hepatitis E virus strains in Bali and Sumbawa, Indonesia. ( 29404765 )
2018
14
Comparison of hepatitis E virus seroprevalence between HBsAg-positive population and healthy controls in Shandong province, China. ( 29433428 )
2018
15
Hepatitis E virus seroprevalence in Polish soldiers serving in harsh environmental conditions. ( 29939391 )
2018
16
Transfusion-Transmitted Hepatitis E: NAT Screening of Blood Donations and Infectious Dose. ( 29450199 )
2018
17
Toward Systematic Screening for Persistent Hepatitis E Virus Infections in Transplant Patients. ( 29953421 )
2018
18
Hepatitis E - A new era in understanding. ( 29936817 )
2018
19
Detection and quantification of hepatitis E virus in the absence of IgG and IgM anti-HEV in HIV positive patients. ( 29920871 )
2018
20
Prevalence of hepatitis E virus RNA and antibodies in a cohort of kidney transplant recipients in Central Brazil. ( 29408465 )
2018
21
Substitution of amino acid residue V1213 in the helicase domain of the genotype 3 hepatitis E virus reduces virus replication. ( 29422085 )
2018
22
Prevalence of hepatitis E in liver transplant recipients in Greece. ( 29974836 )
2018
23
Diversity of hepatitis E virus genotype 3. ( 29939461 )
2018
24
Acute hepatitis E in India appears to be caused exclusively by genotype 1 hepatitis E virus. ( 29399748 )
2018
25
Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4. ( 29435117 )
2018
26
Autochthonous acute hepatitis E mimicking CMV infection. ( 29903610 )
2018
27
Seroprevalence and risk factors of recent infection with hepatitis E virus during an acute outbreak in an urban setting in Chad, 2017. ( 29940939 )
2018
28
Detection and genomic characterization of new avian-like hepatitis E virus in a sparrow in the United States. ( 29971485 )
2018
29
Activities of Thrombin and Factor Xa Are Essential for Replication of Hepatitis E Virus and Are Possibly Implicated in ORF1 Polyprotein Processing. ( 29321328 )
2018
30
Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin. ( 29946850 )
2018
31
Host-Virus Protein Interaction Network Reveals the Involvement of Multiple Host Processes in the Life Cycle of Hepatitis E Virus. ( 29404423 )
2018
32
Interferona89I>4 gene polymorphisms, circulating interferon I>3, and clinical variables in hemodialysis patients exposed to hepatitis E virus. ( 29968695 )
2018
33
Aujeszky's Disease and Hepatitis E Viruses Transmission between Domestic Pigs and Wild Boars in Corsica: Evaluating the Importance of Wild/Domestic Interactions and the Efficacy of Management Measures. ( 29417054 )
2018
34
Elucidating the differences in pathogenicity between hepatitis E virus genotypes: The quest continues. ( 29404519 )
2018
35
A fully automated system using transcription-mediated amplification for the molecular diagnosis of hepatitis E virus in human blood and faeces. ( 29957544 )
2018
36
Benign recurrent intrahepatic cholestasis (BRIC)-like episode associated with ATP8B1 variation underlying protracted cholestatic course of acute hepatitis E virus infection. ( 29191380 )
2018
37
Hepatitis E outbreak at a nursing home for aged people in Hokkaido, Japan, between February and March 2016. ( 29414183 )
2018
38
Chronic Hepatitis E in a Renal Transplant Recipient: The First Report of Genotype 4 Hepatitis E Virus Caused Chronic InfectionA in Organ Recipient. ( 29432746 )
2018
39
Acute Motor Axonal Neuropathy in Association with Hepatitis E. ( 29479336 )
2018
40
Cholemic Nephrosis from Acute Hepatitis E Virus Infection: A Forgotten Entity? ( 29962682 )
2018
41
Acute hepatitis E in French patients and neurological manifestations. ( 29966614 )
2018
42
Hepatitis E virus infection of slaughtered healthy pigs in Brazil. ( 29441690 )
2018
43
Hepatitis E virus replication and interferon responses in human placental cells. ( 29404525 )
2018
44
Guillain-Barre syndrome caused by hepatitis E infection: case report and literature review. ( 29357816 )
2018
45
First Report of the Presence of Hepatitis E Virus in Scottish-Harvested Shellfish Purchased at Retail Level. ( 29442296 )
2018
46
Hepatitis E virus-associated cryoglobulinemia in solid-organ-transplant recipients. ( 29845733 )
2018
47
Liver transplantation for acute liver failure due to hepatitis E in a pregnant patient. ( 30532332 )
2018
48
Acute liver failure caused by hepatitis E virus genotype 3 and 4: A systematic review and pooled analysis. ( 29675889 )
2018
49
Acute liver failure and misdiagnosis: Do not forget viral hepatitis E. ( 30017940 )
2018
50
Case Report: Acute Hepatitis E in a Pediatric Traveler Presenting with Features of Autoimmune Hepatitis: A Diagnostic and Therapeutic Challenge. ( 30350777 )
2018

Variations for Hepatitis E

Expression for Hepatitis E

Search GEO for disease gene expression data for Hepatitis E.

Pathways for Hepatitis E

Pathways related to Hepatitis E according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 CD40LG F2 FGB GRB2 TNF
2
Show member pathways
12.42 CD40LG GRB2 TLR3 TNF
3
Show member pathways
12.42 CD40LG GRB2 IFNG TNF
4
Show member pathways
12.33 F2 GRB2 IFNG TNF
5 12.29 CD40LG IFNG TLR3 TNF
6
Show member pathways
12.11 CD40LG GRB2 IFNG TNF
7
Show member pathways
11.97 GRB2 IFNG TLR3 TNF
8
Show member pathways
11.89 ALB F2 IFNG TNF
9 11.86 GRB2 TLR3 TNF
10
Show member pathways
11.84 IFNG TLR3 TNF
11 11.82 GRB2 IFNG TNF
12
Show member pathways
11.8 F2 IFNG TNF
13
Show member pathways
11.62 F2 FGB GRB2
14
Show member pathways
11.49 CD40LG IFNG TNF
15
Show member pathways
11.49 IFNG TLR3 TNF VPS4A
16
Show member pathways
11.3 CD40LG IFNG TNF
17 11.14 GRB2 IFNG TLR3 TNF
18 11.02 CD40LG IFNG TNF
19 10.92 GRB2 IFNG

GO Terms for Hepatitis E

Cellular components related to Hepatitis E according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 ALB AMBP F2 FGB GPT GRB2
2 cell surface GO:0009986 9.65 AMBP CD40LG FGB TLR3 TNF
3 external side of plasma membrane GO:0009897 9.62 CD40LG F2 FGB TNF
4 extracellular space GO:0005615 9.28 ALB AMBP CD40LG F2 FGB GPT
5 blood microparticle GO:0072562 9.26 ALB AMBP F2 FGB

Biological processes related to Hepatitis E according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.91 CD40LG F2 IFNG TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 CD40LG TLR3 TNF
3 response to virus GO:0009615 9.69 IFNG TLR3 TNF
4 platelet activation GO:0030168 9.67 CD40LG F2 FGB
5 protein import into nucleus, translocation GO:0000060 9.61 IFNG TNF
6 fibrinolysis GO:0042730 9.6 F2 FGB
7 positive regulation of osteoclast differentiation GO:0045672 9.58 IFNG TNF
8 viral budding via host ESCRT complex GO:0039702 9.58 TSG101 VPS4A
9 positive regulation of chemokine production GO:0032722 9.57 TLR3 TNF
10 microglial cell activation GO:0001774 9.56 TLR3 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IFNG TNF
12 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 9.54 TSG101 VPS4A
13 extrinsic apoptotic signaling pathway GO:0097191 9.54 IFNG TLR3 TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 FGB TNF
15 positive regulation of viral release from host cell GO:1902188 9.48 TSG101 VPS4A
16 positive regulation of chemokine biosynthetic process GO:0045080 9.46 TLR3 TNF
17 necroptotic signaling pathway GO:0097527 9.43 TLR3 TNF
18 regulation of immunoglobulin secretion GO:0051023 9.4 CD40LG TNF
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
20 positive regulation of viral budding via host ESCRT complex GO:1903774 9.26 TSG101 VPS4A
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 IFNG TNF
22 positive regulation of interleukin-12 production GO:0032735 9.13 CD40LG IFNG TLR3
23 positive regulation of exosomal secretion GO:1903543 8.8 IFNG TSG101 VPS4A

Sources for Hepatitis E

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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