MCID: HPT067
MIFTS: 44

Hepatocellular Adenoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatocellular Adenoma

MalaCards integrated aliases for Hepatocellular Adenoma:

Name: Hepatocellular Adenoma 12 58 15 17 71
Adenoma Hepatocellular 54

Characteristics:

Orphanet epidemiological data:

58
hepatocellular adenoma
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:0050868
MESH via Orphanet 44 D018248
ICD10 via Orphanet 33 D13.4
UMLS via Orphanet 72 C0206669
Orphanet 58 ORPHA54272
UMLS 71 C0206669

Summaries for Hepatocellular Adenoma

Disease Ontology : 12 A liver benign neoplasm that is located in liver cells and that is composed of epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards based summary : Hepatocellular Adenoma, also known as adenoma hepatocellular, is related to glycogen storage disease ia and liver adenomatosis. An important gene associated with Hepatocellular Adenoma is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Metabolism and Drug metabolism - cytochrome P450. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver cells, liver and bone, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It... more...

Related Diseases for Hepatocellular Adenoma

Diseases related to Hepatocellular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 glycogen storage disease ia 31.1 SLC37A4 HNF1A G6PC
2 liver adenomatosis 30.8 HNF1A CTNNB1
3 glycogen storage disease 30.4 SLC37A4 HNF1A G6PC AFP
4 peliosis hepatis 29.5 GLUL AFP
5 body mass index quantitative trait locus 11 29.4 SREBF1 HNF1A G6PC FABP1 CYP1A2 CTNNB1
6 hepatoblastoma 29.1 HNF1A GPC3 CTNNB1 AFP
7 fibrolamellar carcinoma 28.9 GPC3 GLUL CTNNB1 AFP
8 teratoma 28.7 GPC3 CTNNB1 CDH1 AFP
9 hepatocellular carcinoma 27.3 SREBF1 SLCO1B3 HNF1A GSTP1 GPC3 GLUL
10 hepatic adenomas, familial 12.1
11 adenoma 11.1
12 vulvar intraepithelial neoplasia 10.4 CTNNB1 CDH1
13 mixed epithelial stromal tumour 10.4 CYP1B1 CYP1A2
14 goblet cell carcinoid 10.4 CTNNB1 CDH1
15 mammographic density 10.4 CYP1B1 CYP1A1
16 vaginal adenoma 10.4 CYP1A1 CTNNB1
17 acetaminophen metabolism 10.3 GSTP1 CYP1A2 CYP1A1
18 vaginal benign neoplasm 10.3 CYP1A1 CTNNB1
19 hyperbilirubinemia, rotor type 10.3 SLCO1B3 SLCO1B1
20 fatty liver disease, nonalcoholic 1 10.3
21 glycogen storage disease due to glucose-6-phosphatase deficiency 10.3
22 plasmacytoma 10.3 IL6ST IL11 CTNNB1
23 gastrointestinal system benign neoplasm 10.3 HNF1A CTNNB1 CDH1
24 breast carcinoma in situ 10.3 IL6ST CTNNB1 CDH1
25 liver disease 10.2
26 colorectal adenoma 10.2 GSTP1 CTNNB1 CDH1
27 familial adenomatous polyposis 10.1
28 amyloidosis 10.1
29 fatty liver disease 10.1
30 barrett esophagus 10.1 GSTP1 CYP1A1 CTNNB1 CDH1
31 maturity-onset diabetes of the young 10.1
32 liver cirrhosis 10.1
33 amyloidosis aa 10.1
34 intrahepatic bile duct adenoma 10.0 HNF1A AFP
35 extragonadal nonseminomatous germ cell tumor 10.0 G6PC AFP
36 non-alcoholic fatty liver disease 10.0
37 polycystic ovary syndrome 10.0
38 hemosiderosis 10.0
39 posttransplant acute limbic encephalitis 10.0
40 rare hereditary hemochromatosis 10.0
41 intrahepatic cholestasis of pregnancy 10.0 SLCO1B3 SLCO1B1 CYP1A1
42 lynch syndrome 10.0 GSTP1 CYP1A1 CTNNB1 CDH1 ASS1
43 polykaryocytosis inducer 9.9
44 fanconi anemia, complementation group a 9.9
45 maturity-onset diabetes of the young, type 3 9.9
46 beta-thalassemia 9.9
47 non-alcoholic steatohepatitis 9.9
48 thalassemia 9.9
49 nephrotic syndrome 9.9
50 telangiectasis 9.9

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to Hepatocellular Adenoma

Symptoms & Phenotypes for Hepatocellular Adenoma

GenomeRNAi Phenotypes related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.6 CDH1
2 Decreased viability GR00249-S 9.6 AFP CYP1B1 G6PC GLUL GSTP1 SLCO1B3
3 Decreased viability GR00301-A 9.6 CDH1
4 Decreased viability GR00381-A-1 9.6 CYP1A1
5 Decreased viability GR00386-A-1 9.6 CYP1A1 GSTP1 SLC37A4 SLCO1B1 UGT2B7
6 Decreased viability GR00402-S-2 9.6 AFP CDH1 CYP1A2 IL11

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 AFP ASS1 CDH1 CTNNB1 CYP1A1 CYP1A2
2 liver/biliary system MP:0005370 10.03 AFP CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC
3 mortality/aging MP:0010768 10 AFP ASS1 CDH1 CTNNB1 CYP1A1 CYP1A2
4 neoplasm MP:0002006 9.56 AFP CDH1 CTNNB1 CYP1A2 CYP1B1 G6PC
5 normal MP:0002873 9.23 ASS1 CDH1 CTNNB1 CYP1A1 CYP1A2 G6PC

Drugs & Therapeutics for Hepatocellular Adenoma

Drugs for Hepatocellular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Selective Internal Radiation Therapy for Hepatocellular Carcinomas With Yttrium-90 Loaded Microspheres: Optimized Dosimetry Versus Standard Dosimetry Completed NCT02582034 Phase 2
2 Preoperative Evaluation of the Remaining Part of the Liver for Liver Resection Not yet recruiting NCT04100304

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

Anatomical Context for Hepatocellular Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatocellular Adenoma:

19
Liver Cells

MalaCards organs/tissues related to Hepatocellular Adenoma:

40
Liver, Bone, Placenta, Bone Marrow, Ovary, Skin, Brain

Publications for Hepatocellular Adenoma

Articles related to Hepatocellular Adenoma:

(show top 50) (show all 967)
# Title Authors PMID Year
1
Normoglycemia alone is insufficient to prevent long-term complications of hepatocellular adenoma in glycogen storage disease type Ib mice. 61 54
19376605 2009
2
Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology. 61 54
18803590 2009
3
Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions. 54 61
18976006 2008
4
Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis. 61 54
17535860 2007
5
Genotype phenotype classification of hepatocellular adenoma. 61 54
17569132 2007
6
HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation. 54 61
17379603 2007
7
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. 61 54
17363580 2007
8
Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli. 54 61
17049664 2006
9
Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. 61 54
16606445 2006
10
Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. 61 54
16496320 2006
11
Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. 54 61
15897561 2005
12
Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. 61 54
15287021 2004
13
Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. 61 54
12660822 2003
14
Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution. 54 61
9371521 1997
15
[Hepatocellular adenoma with a high level of alpha fetoprotein. Apropos of a case observed in the Central hospital of Yaoundé, Cameroon]. 61 54
1284392 1992
16
New insights in the management of Hepatocellular Adenoma. 61
32464711 2020
17
Limited added value of contrast-enhanced ultrasound over B-mode for the subtyping of hepatocellular adenomas. 61
32361381 2020
18
Gene therapy using a novel G6PC-S298C variant enhances the long-term efficacy for treating glycogen storage disease type Ia. 61
32430177 2020
19
Hepatocellular adenomas: is there additional value in using Gd-EOB-enhanced MRI for subtype differentiation? 61
32086574 2020
20
A Shifting Paradigm in Diagnosis and Management of Hepatic Adenoma. 61
32542565 2020
21
Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance. 61
32320717 2020
22
Steatohepatitis-Like Changes in Hepatocellular Adenoma. 61
32561910 2020
23
Characterization of Indeterminate Liver Lesions on CT and MRI With Contrast-Enhanced Ultrasound: What Is the Evidence? 61
32182094 2020
24
ASO Author Reflections: Developing Personalized Care for Hepatocellular Adenoma Based on Subtype Classification. 61
32548754 2020
25
Hepatocellular adenoma in the paediatric population: Molecular classification and clinical associations. 61
32476794 2020
26
Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns. 61
32002637 2020
27
Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report. 61
32382834 2020
28
CT-Based Radiomics Nomogram: A Potential Tool for Differentiating Hepatocellular Adenoma From Hepatocellular Carcinoma in the Noncirrhotic Liver. 61
32386828 2020
29
Hepatic nodules with arterial phase hyperenhancement and washout on enhanced computed tomography/magnetic resonance imaging: how to avoid pitfalls. 61
32377756 2020
30
Management of patients with hepatocellular adenoma: a single-institution experience. 61
31943651 2020
31
Exercise Attenuates the Transition from Fatty Liver to Steatohepatitis and Reduces Tumor Formation in Mice. 61
32486073 2020
32
Primary hepatic neuroendocrine tumor: A case report and literature review. 61
32506020 2020
33
Emerging roles of autophagy in hepatic tumorigenesis and therapeutic strategies in glycogen storage disease type Ia: a review. 61
32474930 2020
34
Adrenocortical Scintigraphy With SPECT/CT for the Diagnosis of Hepatic Adrenal Rest. 61
31789919 2020
35
Characteristics of atypical large well-differentiated hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma? 61
31533893 2020
36
Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon. 61
31570768 2020
37
A multicentre retrospective analysis on growth of residual hepatocellular adenoma after resection. 61
32279413 2020
38
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype. 61
31698521 2020
39
Primary hepatocellular adenoma due to biallelic HNF1A mutations and its co-occurrence with MODY 3: case-report and review of the literature. 61
31754975 2020
40
Fluxametamide (Pesticides). 61
32231959 2020
41
Spontaneous Tumors and Non-Neoplastic Proliferative Lesions in Pet Degus (Octodon degus). 61
32183187 2020
42
Hepatocellular adenoma(s) arising in nodular regenerative hyperplasia in a patient with systemic lupus erythematosus. 61
31810588 2020
43
Multidisciplinary management of the pregnant patient in haemorrhagic shock secondary to an undiagnosed ruptured liver adenoma. 61
32060109 2020
44
Reply to "Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia". 61
32022384 2020
45
Performance of Contrast-Enhanced Sonography Versus MRI With a Liver-Specific Contrast Agent for Diagnosis of Hepatocellular Adenoma and Focal Nodular Hyperplasia. 61
31573852 2020
46
Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia. 61
31735334 2020
47
Large size and haemorrhage are not contraindications to laparoscopic resection of hepatocellular adenoma. 61
31983071 2020
48
Inflammatory hepatocellular adenoma, focal nodular hyperplasia and hepatic granulomas in one single patient : possible physiopathologic explanations. 61
32233277 2020
49
Model to Predict Regression of Large-Size Hepatocellular Adenoma: More Information Needed. 61
31577569 2020
50
Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. 61
31816064 2020

Variations for Hepatocellular Adenoma

Expression for Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for Hepatocellular Adenoma

Pathways related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 UGT2B7 SREBF1 SLCO1B3 SLCO1B1 SLC37A4 GSTP1
2
Show member pathways
12.73 UGT2B7 GSTP1 CYP1B1 CYP1A2 CYP1A1
3 12.29 SREBF1 HNF1A GLUL FABP1 CYP1A2 ASS1
4 11.93 SREBF1 IL6ST HNF1A CTNNB1
5
Show member pathways
11.85 UGT2B7 SLCO1B3 SLCO1B1 GSTP1
6
Show member pathways
11.76 CYP1B1 CYP1A2 CYP1A1
7 11.74 UGT2B7 SLCO1B3 SLCO1B1
8
Show member pathways
11.66 GSTP1 CYP1A2 CYP1A1
9
Show member pathways
11.63 UGT2B7 SLCO1B3 SLCO1B1 CYP1A2
10
Show member pathways
11.53 UGT2B7 CYP1B1 CYP1A2 CYP1A1
11
Show member pathways
11.46 SLCO1B3 CYP1B1 CYP1A1
12 11.42 CYP1B1 CYP1A2 CYP1A1
13 11.4 CYP1B1 CYP1A2 CYP1A1
14 11.36 HNF1A G6PC AFP
15 11.27 CYP1B1 CYP1A2 CYP1A1
16
Show member pathways
11.15 UGT2B7 CYP1B1 CYP1A2 CYP1A1
17 11.03 GSTP1 CYP1A2 CYP1A1
18
Show member pathways
11 UGT2B7 CYP1B1 CYP1A2 CYP1A1
19
Show member pathways
10.83 CYP1A2 CYP1A1
20
Show member pathways
10.79 SLCO1B3 SLCO1B1 CYP1A2 CYP1A1
21 10.73 CTNNB1 CDH1
22 10.66 CYP1B1 CYP1A2 CYP1A1
23
Show member pathways
10.63 CYP1B1 CYP1A2
24 10.53 UGT2B7 CYP1A2
25
Show member pathways
10.46 UGT2B7 CYP1B1 CYP1A2 CYP1A1

GO Terms for Hepatocellular Adenoma

Cellular components related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.8 UGT2B7 SREBF1 SLC37A4 G6PC CYP1B1 CYP1A2
2 endoplasmic reticulum GO:0005783 9.61 UGT2B7 SREBF1 SLC37A4 GLUL G6PC CYP1B1
3 organelle membrane GO:0031090 9.46 UGT2B7 CYP1B1 CYP1A2 CYP1A1
4 flotillin complex GO:0016600 9.32 CTNNB1 CDH1
5 intracellular membrane-bounded organelle GO:0043231 9.23 UGT2B7 SREBF1 SLC37A4 GLUL G6PC CYP1B1

Biological processes related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10.04 UGT2B7 SREBF1 CYP1B1 CYP1A2 CYP1A1
2 response to organic cyclic compound GO:0014070 9.83 SREBF1 SLC37A4 CYP1A2 CYP1A1
3 cellular response to insulin stimulus GO:0032869 9.82 SREBF1 GSTP1 G6PC
4 cholesterol metabolic process GO:0008203 9.81 SREBF1 HNF1A CYP1A2
5 xenobiotic metabolic process GO:0006805 9.8 GSTP1 CYP1B1 CYP1A2
6 response to organic substance GO:0010033 9.8 CYP1A2 CYP1A1 CDH1
7 response to estradiol GO:0032355 9.8 GSTP1 CYP1A2 CTNNB1 ASS1
8 response to drug GO:0042493 9.8 SREBF1 CYP1A2 CYP1A1 CTNNB1 CDH1 ASS1
9 liver development GO:0001889 9.79 HNF1A CYP1A1 ASS1
10 lung development GO:0030324 9.78 SREBF1 GPC3 CYP1A2 CTNNB1
11 retinol metabolic process GO:0042572 9.73 CYP1B1 CYP1A2 CYP1A1
12 glycogen metabolic process GO:0005977 9.72 SLC37A4 IL6ST G6PC
13 bile acid and bile salt transport GO:0015721 9.69 SLCO1B3 SLCO1B1 HNF1A
14 response to glucose GO:0009749 9.67 SREBF1 SLC37A4 HNF1A GLUL
15 response to food GO:0032094 9.63 SREBF1 G6PC CYP1A1
16 hydrogen peroxide biosynthetic process GO:0050665 9.61 CYP1A2 CYP1A1
17 entry of bacterium into host cell GO:0035635 9.61 CTNNB1 CDH1
18 epoxygenase P450 pathway GO:0019373 9.61 CYP1B1 CYP1A2 CYP1A1
19 heterocycle metabolic process GO:0046483 9.6 CYP1A2 CYP1A1
20 glucose-6-phosphate transport GO:0015760 9.59 SLC37A4 G6PC
21 cellular response to indole-3-methanol GO:0071681 9.58 CTNNB1 CDH1
22 porphyrin-containing compound metabolic process GO:0006778 9.58 CYP1A2 CYP1A1
23 estrogen metabolic process GO:0008210 9.58 CYP1B1 CYP1A2 CYP1A1
24 cellular aromatic compound metabolic process GO:0006725 9.57 CYP1B1 CYP1A2
25 dibenzo-p-dioxin metabolic process GO:0018894 9.54 CYP1A2 CYP1A1
26 omega-hydroxylase P450 pathway GO:0097267 9.43 CYP1B1 CYP1A2 CYP1A1
27 response to toxic substance GO:0009636 9.35 GSTP1 CYP1B1 CYP1A1 CDH1 ASS1
28 toxin metabolic process GO:0009404 9.33 CYP1B1 CYP1A2 CYP1A1
29 steroid metabolic process GO:0008202 9.17 UGT2B7 SREBF1 SLC37A4 G6PC CYP1B1 CYP1A2

Molecular functions related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 9.61 CYP1B1 CYP1A2 CYP1A1
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.58 CYP1B1 CYP1A2 CYP1A1
3 bile acid transmembrane transporter activity GO:0015125 9.46 SLCO1B3 SLCO1B1
4 fatty acid binding GO:0005504 9.43 GSTP1 FABP1 AFP
5 demethylase activity GO:0032451 9.37 CYP1A2 CYP1A1
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.33 CYP1B1 CYP1A2 CYP1A1
7 estrogen 2-hydroxylase activity GO:0101021 9.32 CYP1A2 CYP1A1
8 aromatase activity GO:0070330 9.13 CYP1B1 CYP1A2 CYP1A1
9 estrogen 16-alpha-hydroxylase activity GO:0101020 8.8 CYP1B1 CYP1A2 CYP1A1

Sources for Hepatocellular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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