MCID: HPT067
MIFTS: 43

Hepatocellular Adenoma

Categories: Liver diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Hepatocellular Adenoma

MalaCards integrated aliases for Hepatocellular Adenoma:

Name: Hepatocellular Adenoma 12 59 15 73

Characteristics:

Orphanet epidemiological data:

59
hepatocellular adenoma
Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:0050868
Orphanet 59 ORPHA54272
MESH via Orphanet 45 D018248
UMLS via Orphanet 74 C0206669
ICD10 via Orphanet 34 D13.4
UMLS 73 C0206669

Summaries for Hepatocellular Adenoma

MalaCards based summary : Hepatocellular Adenoma is related to hepatic adenomas, familial and adenoma. An important gene associated with Hepatocellular Adenoma is GLUL (Glutamate-Ammonia Ligase), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and placenta, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 76 Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It... more...

Related Diseases for Hepatocellular Adenoma

Diseases related to Hepatocellular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 hepatic adenomas, familial 32.3 CTNNB1 G6PC HNF1A
2 adenoma 10.9
3 hepatocellular carcinoma 10.3
4 glycogen storage disease 10.3
5 hepatitis 10.1
6 type i 10.1
7 glycogen storage disease ia 10.0
8 familial adenomatous polyposis 10.0
9 glycogen storage disease due to glucose-6-phosphatase deficiency 10.0
10 aging 9.8
11 liver disease 9.8
12 polycystic ovary syndrome 9.8
13 hemosiderosis 9.8
14 amyloidosis 9.8
15 fatty liver disease 9.8
16 fanconi anemia, complementation group a 9.7
17 cholangitis, primary sclerosing 9.7
18 beta-thalassemia 9.7
19 deficiency anemia 9.7
20 hepatitis b 9.7
21 islet cell tumor 9.7
22 thalassemia 9.7
23 thrombosis 9.7
24 nonalcoholic fatty liver disease 9.7
25 glucose intolerance 9.7
26 portal vein thrombosis 9.7
27 iron deficiency anemia 9.7
28 gender identity disorder 9.7
29 sclerosing cholangitis 9.7
30 iron metabolism disease 9.7
31 endometriosis 9.7
32 fibrolamellar carcinoma 9.7
33 hepatoblastoma 9.7
34 peliosis hepatis 9.7
35 cholangitis 9.7
36 congenital hepatic fibrosis 9.7
37 amyloidosis aa 9.7
38 nodular regenerative hyperplasia 9.7
39 glycogen storage disease due to glycogen branching enzyme deficiency 9.7
40 renal dysplasia 9.7
41 kleptomania 9.5 CYP1A2 CYP3A4
42 clopidogrel resistance 9.2 CYP1A1 CYP1A2 CYP3A4
43 acetaminophen metabolism 8.4 CYP1A1 CYP1A2 CYP3A4 GSTP1

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to Hepatocellular Adenoma

Symptoms & Phenotypes for Hepatocellular Adenoma

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ASS1 CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC
2 liver/biliary system MP:0005370 9.56 CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC GLUL
3 normal MP:0002873 9.1 ASS1 CTNNB1 CYP1A1 G6PC GLUL IL6ST

Drugs & Therapeutics for Hepatocellular Adenoma

Drugs for Hepatocellular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
2
Racepinephrine Approved Not Applicable 329-65-7 838
3 Coagulants Not Applicable
4 Epinephryl borate Not Applicable
5 Hemostatics Not Applicable
6 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

Anatomical Context for Hepatocellular Adenoma

MalaCards organs/tissues related to Hepatocellular Adenoma:

41
Liver, Bone Marrow, Placenta, Bone, Ovary, Testes, Pancreas

Publications for Hepatocellular Adenoma

Articles related to Hepatocellular Adenoma:

(show top 50) (show all 279)
# Title Authors Year
1
Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance. ( 29116626 )
2018
2
Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma. ( 29740826 )
2018
3
Hepatocellular adenoma in a woman who was undergoing testosterone treatment for gender identity disorder. ( 29589251 )
2018
4
Molecular classification of hepatocellular adenoma in clinical practice. ( 28733222 )
2017
5
Intravoxel incoherent motion and dynamic contrast-enhanced MRI for differentiation between hepatocellular adenoma and focal nodular hyperplasia. ( 28590780 )
2017
6
Quantitative analysis Of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of LLCER method using gadobenate dimeglumine as contrast agent. ( 28589549 )
2017
7
Screening the key genes of hepatocellular adenoma via microarray analysis of DNA expression and methylation profiles. ( 28943905 )
2017
8
A cost-effectiveness analysis of the diagnostic strategies for differentiating focal nodular hyperplasia from hepatocellular adenoma. ( 28726119 )
2017
9
Unexpected discovery of small HNF1I+-inactivated hepatocellular adenoma in pathological specimens from patients resected for liver tumours. ( 29265678 )
2017
10
Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1I+-inactivated variant. ( 28992889 )
2017
11
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma. ( 29127141 )
2017
12
Management and outcome of hepatocellular adenoma with massive bleeding at presentation. ( 28740346 )
2017
13
Hepatocellular adenoma: Classification, variants and clinical relevance. ( 28131467 )
2017
14
Retrospective study on timing of resection of hepatocellular adenoma. ( 28857134 )
2017
15
Laparoscopic liver resection for hemorrhagic hepatocellular adenoma in a pregnant patient. ( 28982300 )
2017
16
Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination. ( 28323122 )
2017
17
Short-term outcomes of laparoscopic vs. open liver resection for hepatocellular adenoma: a multicenter propensity score adjustment analysis by the AFC-HCA-2013 study group. ( 28281121 )
2017
18
Argininosuccinate synthase 1 (ASS1): A marker of unclassified hepatocellular adenoma and high bleeding risk. ( 28646562 )
2017
19
Malignant potential of hepatocellular adenoma. ( 28635168 )
2017
20
Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia. ( 29281780 )
2017
21
Inflammatory and multiple hepatocellular adenoma are associated with a higher BMI. ( 28704224 )
2017
22
Correction to: Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? ( 29230554 )
2017
23
Hepatocellular adenoma in a European flatfish (Limanda limanda): Genetic alterations in laser-capture micro-dissected tissue and global transcriptomic approach. ( 28473212 )
2017
24
Expression of c-MET Protein in Various Subtypes of Hepatocellular Adenoma Compared to Hepatocellular Carcinoma and Non-Neoplastic Liver in Human Tissue. ( 29256857 )
2017
25
Diagnostic Value of Gd-EOB-DTPA-MRI for Hepatocellular Adenoma: A Meta-Analysis. ( 28607606 )
2017
26
Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? ( 29110059 )
2017
27
Men with biopsy-confirmed hepatocellular adenoma have a high risk of progression to hepatocellular carcinoma: AA nationwide population-based study. ( 28317318 )
2017
28
Response to "Quantitative analysis of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of llcer method using gadobenate dimeglumine as contrast agent". ( 28580722 )
2017
29
Systematic review: benefits and harms of transarterial embolisation for treating hepatocellular adenoma. ( 28318052 )
2017
30
Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat. ( 28190927 )
2017
31
Hepatocellular adenoma among adult survivors of childhood and young adult cancer. ( 27781382 )
2016
32
Malignant Transformation of Hepatocellular Adenoma. ( 27988517 )
2016
33
Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis. ( 27042773 )
2016
34
European experience of 573 liver resections for hepatocellular adenoma: a cross-sectional study by the AFC-HCA-2013 study group. ( 27593592 )
2016
35
Hepatocellular adenoma: when and how to treat? Update of current evidence. ( 27803743 )
2016
36
Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report. ( 27900094 )
2016
37
Hepatocellular adenoma: comparison between real-time contrast-enhanced ultrasound and dynamic computed tomography. ( 27386395 )
2016
38
Ultrasound features of hepatocellular adenoma and the additional value of contrast-enhanced ultrasound. ( 26818543 )
2016
39
PET-avid hepatocellular adenomas: incidental findings associated with HNF1-I+ mutated lesions. ( 26776850 )
2016
40
Distinction Between Inflammatory Hepatocellular Adenoma and Mass Effect on Liver Sampling. ( 27989788 )
2016
41
Evidence of good prognosis of hepatocellular adenoma in post-menopausal women. ( 27524464 )
2016
42
Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver? ( 27660679 )
2016
43
Hepatocellular Adenoma of the Placenta With Updated Immunohistochemical and Molecular Markers: A Case Report. ( 27106781 )
2016
44
Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis. ( 26961851 )
2016
45
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma. ( 26769138 )
2016
46
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. ( 27939373 )
2016
47
Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma. ( 27189732 )
2016
48
Hepatoblastoma Arising in a Pigmented I^-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature. ( 27096257 )
2016
49
Outcomes of liver resection for haemorrhagic hepatocellular adenoma. ( 26805568 )
2016
50
Touch cytology smear of an inflammatory hepatocellular adenoma displaying an unusual pattern: A case report. ( 27434199 )
2016

Variations for Hepatocellular Adenoma

Expression for Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for Hepatocellular Adenoma

Pathways related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 ASS1 CYP1A1 CYP1A2 CYP3A4 FABP1 G6PC
2
Show member pathways
13 CYP1A1 CYP1A2 CYP3A4 GSTP1 UGT2B7
3
Show member pathways
12.52 CYP1A1 CYP1A2 CYP3A4 GSTP1 UGT2B7
4 12.12 ASS1 CYP1A2 CYP3A4 FABP1 GLUL HNF1A
5
Show member pathways
12.03 CYP1A1 CYP1A2 CYP3A4
6 11.89 ASS1 CTNNB1 GSTP1
7 11.89 CTNNB1 HNF1A IL6ST
8 11.85 CTNNB1 HNF1A IL6ST
9
Show member pathways
11.57 CYP1A1 CYP1A2 CYP3A4 GSTP1
10
Show member pathways
11.48 CYP1A1 CYP1A2 CYP3A4
11
Show member pathways
11.44 CYP1A1 CYP1A2 CYP3A4 UGT2B7
12
Show member pathways
11.4 CYP1A2 CYP3A4 UGT2B7
13
Show member pathways
11.37 CYP1A1 CYP1A2 CYP3A4
14
Show member pathways
11.34 CYP1A1 CYP1A2 CYP3A4 UGT2B7
15 11.29 G6PC HNF1A
16
Show member pathways
11.22 CYP3A4 UGT2B7
17 11.2 CYP1A1 CYP1A2
18 11.17 ASS1 GLUL
19 11.17 CYP1A2 CYP3A4
20
Show member pathways
11.05 CYP1A2 CYP3A4
21
Show member pathways
11.02 ASS1 GLUL
22
Show member pathways
10.96 CYP1A1 CYP1A2 CYP3A4
23 10.95 CYP1A2 CYP3A4
24 10.88 CYP3A4 UGT2B7
25
Show member pathways
10.79 CYP1A1 CYP1A2 CYP3A4 UGT2B7
26 10.72 CYP3A4 GSTP1
27 10.65 CYP1A1 CYP1A2
28 10.3 CYP1A1 CYP1A2 CYP3A4 GSTP1
29 10.19 CYP3A4 UGT2B7

GO Terms for Hepatocellular Adenoma

Cellular components related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 ASS1 CTNNB1 FABP1 GLUL GSTP1 IL6ST
2 protein-containing complex GO:0032991 9.62 CTNNB1 FABP1 GLUL HNF1A
3 endoplasmic reticulum membrane GO:0005789 9.55 CYP1A1 CYP1A2 CYP3A4 G6PC UGT2B7
4 intracellular membrane-bounded organelle GO:0043231 9.43 CYP1A1 CYP1A2 CYP3A4 G6PC GLUL UGT2B7
5 organelle membrane GO:0031090 8.92 CYP1A1 CYP1A2 CYP3A4 UGT2B7

Biological processes related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.86 ASS1 CTNNB1 CYP1A1 CYP1A2
2 regulation of gene expression GO:0010468 9.82 CTNNB1 CYP1A2 G6PC
3 response to lipopolysaccharide GO:0032496 9.81 ASS1 CYP1A1 CYP1A2
4 response to toxic substance GO:0009636 9.75 ASS1 CYP1A1 GSTP1
5 xenobiotic metabolic process GO:0006805 9.71 CYP1A2 CYP3A4 GSTP1
6 liver development GO:0001889 9.7 ASS1 CYP1A1 HNF1A
7 glycogen metabolic process GO:0005977 9.64 G6PC IL6ST
8 response to amino acid GO:0043200 9.64 ASS1 GSTP1
9 cellular response to copper ion GO:0071280 9.63 CYP1A1 CYP1A2
10 exogenous drug catabolic process GO:0042738 9.62 CYP1A2 CYP3A4
11 response to food GO:0032094 9.62 CYP1A1 G6PC
12 response to immobilization stress GO:0035902 9.61 CYP1A1 CYP1A2
13 bone resorption GO:0045453 9.61 CTNNB1 HNF1A
14 epoxygenase P450 pathway GO:0019373 9.6 CYP1A1 CYP1A2
15 androgen metabolic process GO:0008209 9.59 CYP3A4 UGT2B7
16 vitamin D metabolic process GO:0042359 9.58 CYP1A1 CYP3A4
17 oxidative demethylation GO:0070989 9.57 CYP1A2 CYP3A4
18 omega-hydroxylase P450 pathway GO:0097267 9.55 CYP1A1 CYP1A2
19 toxin metabolic process GO:0009404 9.51 CYP1A1 CYP1A2
20 hydrogen peroxide biosynthetic process GO:0050665 9.49 CYP1A1 CYP1A2
21 drug catabolic process GO:0042737 9.48 CYP1A2 CYP3A4
22 monoterpenoid metabolic process GO:0016098 9.46 CYP1A2 CYP3A4
23 response to estradiol GO:0032355 9.46 ASS1 CTNNB1 CYP1A2 GSTP1
24 lipid hydroxylation GO:0002933 9.43 CYP1A1 CYP3A4
25 drug metabolic process GO:0017144 9.43 CYP1A1 CYP1A2 CYP3A4
26 steroid catabolic process GO:0006706 9.4 CYP1A2 CYP3A4
27 porphyrin-containing compound metabolic process GO:0006778 9.37 CYP1A1 CYP1A2
28 dibenzo-p-dioxin metabolic process GO:0018894 9.32 CYP1A1 CYP1A2
29 heterocycle metabolic process GO:0046483 9.13 CYP1A1 CYP1A2 CYP3A4
30 steroid metabolic process GO:0008202 9.02 CYP1A1 CYP1A2 CYP3A4 G6PC UGT2B7

Molecular functions related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.76 CTNNB1 CYP1A1 CYP1A2 CYP3A4
2 iron ion binding GO:0005506 9.67 CYP1A1 CYP1A2 CYP3A4
3 heme binding GO:0020037 9.65 CYP1A1 CYP1A2 CYP3A4
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.61 CYP1A1 CYP1A2 CYP3A4
5 monooxygenase activity GO:0004497 9.54 CYP1A1 CYP1A2 CYP3A4
6 steroid hydroxylase activity GO:0008395 9.52 CYP1A1 CYP3A4
7 aromatase activity GO:0070330 9.51 CYP1A1 CYP1A2
8 estrogen 16-alpha-hydroxylase activity GO:0101020 9.4 CYP1A1 CYP3A4
9 oxygen binding GO:0019825 9.33 CYP1A1 CYP1A2 CYP3A4
10 demethylase activity GO:0032451 9.32 CYP1A1 CYP1A2
11 caffeine oxidase activity GO:0034875 9.26 CYP1A2 CYP3A4
12 vitamin D 24-hydroxylase activity GO:0070576 8.96 CYP1A1 CYP3A4
13 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.8 CYP1A1 CYP1A2 CYP3A4

Sources for Hepatocellular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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