MCID: HPT067
MIFTS: 43

Hepatocellular Adenoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatocellular Adenoma

MalaCards integrated aliases for Hepatocellular Adenoma:

Name: Hepatocellular Adenoma 12 58 15 17 71
Adenoma Hepatocellular 54

Characteristics:

Orphanet epidemiological data:

58
hepatocellular adenoma
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:0050868
MESH via Orphanet 44 D018248
ICD10 via Orphanet 33 D13.4
UMLS via Orphanet 72 C0206669
Orphanet 58 ORPHA54272
UMLS 71 C0206669

Summaries for Hepatocellular Adenoma

Disease Ontology : 12 A liver benign neoplasm that is located in liver cells and that is composed of epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards based summary : Hepatocellular Adenoma, also known as adenoma hepatocellular, is related to liver adenomatosis and glycogen storage disease. An important gene associated with Hepatocellular Adenoma is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Metabolism and Drug metabolism - cytochrome P450. The drugs Liver Extracts and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include liver cells, liver and bone, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 74 Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It... more...

Related Diseases for Hepatocellular Adenoma

Diseases related to Hepatocellular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 liver adenomatosis 30.8 HNF1A CTNNB1
2 glycogen storage disease 30.4 SLC37A4 HNF1A G6PC AFP
3 peliosis hepatis 29.5 GLUL AFP
4 hepatoblastoma 29.1 HNF1A GPC3 CTNNB1 AFP
5 fibrolamellar carcinoma 29.1 GPC3 CTNNB1 AFP
6 teratoma 28.7 GPC3 CTNNB1 CDH1 AFP
7 hepatocellular carcinoma 27.3 SREBF1 SLCO1B3 HNF1A GSTP1 GPC3 GLUL
8 hepatic adenomas, familial 12.1
9 adenoma 11.1
10 mixed epithelial stromal tumour 10.4 CYP1B1 CYP1A2
11 vulvar intraepithelial neoplasia 10.4 CTNNB1 CDH1
12 goblet cell carcinoid 10.4 CTNNB1 CDH1
13 mammographic density 10.4 CYP1B1 CYP1A1
14 glycogen storage disease ia 10.4
15 acetaminophen metabolism 10.3 GSTP1 CYP1A2 CYP1A1
16 fatty liver disease, nonalcoholic 1 10.3
17 glycogen storage disease due to glucose-6-phosphatase deficiency 10.3
18 hyperbilirubinemia, rotor type 10.3 SLCO1B3 SLCO1B1
19 liver disease 10.2
20 colorectal adenoma 10.2 GSTP1 CTNNB1 CDH1
21 lynch syndrome 10.2 GSTP1 CYP1A1 CTNNB1 ASS1
22 familial adenomatous polyposis 10.1
23 amyloidosis 10.1
24 maturity-onset diabetes of the young 10.1
25 liver cirrhosis 10.1
26 fatty liver disease 10.1
27 amyloidosis aa 10.1
28 familial hyperlipidemia 10.1 SREBF1 SLC37A4 G6PC
29 intrahepatic cholestasis of pregnancy 10.1 SLCO1B3 SLCO1B1 CYP1A1
30 extragonadal nonseminomatous germ cell tumor 10.0 G6PC AFP
31 polycystic ovary syndrome 10.0
32 hemosiderosis 10.0
33 posttransplant acute limbic encephalitis 10.0
34 rare hereditary hemochromatosis 10.0
35 embryonal sarcoma 10.0 GPC3 CTNNB1
36 liver sarcoma 9.9 FABP1 AFP
37 fanconi anemia, complementation group a 9.9
38 body mass index quantitative trait locus 11 9.9
39 maturity-onset diabetes of the young, type 3 9.9
40 body mass index quantitative trait locus 9 9.9
41 body mass index quantitative trait locus 8 9.9
42 body mass index quantitative trait locus 4 9.9
43 body mass index quantitative trait locus 10 9.9
44 body mass index quantitative trait locus 7 9.9
45 body mass index quantitative trait locus 12 9.9
46 body mass index quantitative trait locus 14 9.9
47 beta-thalassemia 9.9
48 body mass index quantitative trait locus 18 9.9
49 body mass index quantitative trait locus 19 9.9
50 body mass index quantitative trait locus 20 9.9

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to Hepatocellular Adenoma

Symptoms & Phenotypes for Hepatocellular Adenoma

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.16 AFP ASS1 CDH1 CTNNB1 CYP1A1 CYP1A2
2 liver/biliary system MP:0005370 9.93 AFP CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC
3 mortality/aging MP:0010768 9.8 AFP ASS1 CDH1 CTNNB1 CYP1A1 CYP1A2
4 neoplasm MP:0002006 9.17 AFP CDH1 CTNNB1 CYP1A2 CYP1B1 G6PC

Drugs & Therapeutics for Hepatocellular Adenoma

Drugs for Hepatocellular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts
2 Hematinics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Selective Internal Radiation Therapy for Hepatocellular Carcinomas With Yttrium-90 Loaded Microspheres: Optimized Dosimetry Versus Standard Dosimetry Completed NCT02582034 Phase 2
2 Preoperative Evaluation of the Remaining Part of the Liver for Liver Resection Not yet recruiting NCT04100304

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

Anatomical Context for Hepatocellular Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatocellular Adenoma:

19
Liver Cells

MalaCards organs/tissues related to Hepatocellular Adenoma:

40
Liver, Bone, Bone Marrow, Ovary, Placenta, Skin, Brain

Publications for Hepatocellular Adenoma

Articles related to Hepatocellular Adenoma:

(show top 50) (show all 944)
# Title Authors PMID Year
1
Normoglycemia alone is insufficient to prevent long-term complications of hepatocellular adenoma in glycogen storage disease type Ib mice. 54 61
19376605 2009
2
Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology. 54 61
18803590 2009
3
Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions. 54 61
18976006 2008
4
Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis. 54 61
17535860 2007
5
Genotype phenotype classification of hepatocellular adenoma. 54 61
17569132 2007
6
HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation. 54 61
17379603 2007
7
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. 54 61
17363580 2007
8
Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli. 54 61
17049664 2006
9
Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. 54 61
16606445 2006
10
Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. 54 61
16496320 2006
11
Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. 54 61
15897561 2005
12
Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. 54 61
15287021 2004
13
Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. 54 61
12660822 2003
14
Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution. 54 61
9371521 1997
15
[Hepatocellular adenoma with a high level of alpha fetoprotein. Apropos of a case observed in the Central hospital of Yaoundé, Cameroon]. 54 61
1284392 1992
16
Reply to "Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia". 61
32022384 2020
17
Hepatocellular adenoma(s) arising in nodular regenerative hyperplasia in a patient with systemic lupus erythematosus. 61
31810588 2020
18
Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. 61
31816064 2020
19
Management of patients with hepatocellular adenoma: a single-institution experience. 61
31943651 2020
20
Growth of hepatocellular adenoma during pregnancy: A prospective study. 61
31550458 2020
21
Performance of Contrast-Enhanced Sonography Versus MRI With a Liver-Specific Contrast Agent for Diagnosis of Hepatocellular Adenoma and Focal Nodular Hyperplasia. 61
31573852 2020
22
Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns. 61
32002637 2020
23
Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia. 61
31735334 2020
24
Model to Predict Regression of Large-Size Hepatocellular Adenoma: More Information Needed. 61
31577569 2020
25
Large size and haemorrhage are not contraindications to laparoscopic resection of hepatocellular adenoma. 61
31983071 2020
26
Hyperintense Liver Masses at Hepatobiliary Phase Gadoxetic Acid-enhanced MRI: Imaging Appearances and Clinical Importance. 61
31834849 2020
27
Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital. 61
31836555 2020
28
Diagnosis of Liver Neoplasms by Computational and Statistical Image Analysis. 61
31803308 2019
29
Radiological aspects of giant hepatocellular adenoma of the left liver: A case report. 61
31832416 2019
30
Multi-parameter ultrasound based on the logistic regression model in the differential diagnosis of hepatocellular adenoma and focal nodular hyperplasia. 61
31908724 2019
31
Adrenocortical Scintigraphy With SPECT/CT for the Diagnosis of Hepatic Adrenal Rest. 61
31789919 2019
32
Phenotype or Genotype: Decision-Making Dilemmas in Hepatocellular Adenoma. 61
31206716 2019
33
Diagnosis of hepatocellular adenoma in men before onset of diabetes in HNF1A-MODY: Watch out for winkers. 61
31483937 2019
34
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype. 61
31698521 2019
35
Primary hepatocellular adenoma due to biallelic HNF1A mutations and its co-occurrence with MODY 3: case-report and review of the literature. 61
31754975 2019
36
Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum. 61
31189995 2019
37
Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions. 61
31551364 2019
38
The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences. 61
31685031 2019
39
MRI for characterization of benign hepatocellular tumors on hepatobiliary phase: the added value of in-phase imaging and lesion-to-liver visual signal intensity ratio. 61
30993437 2019
40
Unclassified hepatocellular adenoma expressing ASS1 associated with inflammatory hepatocellular adenomas. 61
31047837 2019
41
Enhancement pattern of hepatocellular adenoma (HCA) on MR imaging performed with Gd-EOB-DTPA versus other Gd-based contrast agents (GBCAs): An intraindividual comparison. 61
31437747 2019
42
Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon. 61
31570768 2019
43
Characteristics of atypical large well-differentiated hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma? 61
31533893 2019
44
Impact of open and minimally invasive resection of symptomatic solid benign liver tumours on symptoms and quality of life: a systematic review. 61
30926331 2019
45
Safety and efficacy of transarterial embolization of hepatocellular adenomas. 61
31313827 2019
46
Case of resected multiple hepatocellular adenomas in a young man with severe obesity. 61
31410698 2019
47
Development and Validation of a Model to Predict Regression of Large Size Hepatocellular Adenoma. 61
30920416 2019
48
Human hepatocellular adenoma as a promising cell source for bioartificial liver systems. 61
31316625 2019
49
A Proteomic Analysis of GSD-1a in Mouse Livers: Evidence for Metabolic Reprogramming, Inflammation, and Macrophage Polarization. 61
31173686 2019
50
[Exploration on laparoscopic hepatectomy on central liver tumor: a report of 40 cases]. 61
31269614 2019

Variations for Hepatocellular Adenoma

Expression for Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for Hepatocellular Adenoma

Pathways related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 UGT2B7 SREBF1 SLCO1B3 SLCO1B1 SLC37A4 GSTP1
2
Show member pathways
12.72 UGT2B7 GSTP1 CYP1B1 CYP1A2 CYP1A1
3 12.29 SREBF1 HNF1A GLUL FABP1 CYP1A2 ASS1
4 11.93 SREBF1 IL6ST HNF1A CTNNB1
5
Show member pathways
11.85 UGT2B7 SLCO1B3 SLCO1B1 GSTP1
6
Show member pathways
11.75 CYP1B1 CYP1A2 CYP1A1
7
Show member pathways
11.66 GSTP1 CYP1A2 CYP1A1
8
Show member pathways
11.63 UGT2B7 SLCO1B3 SLCO1B1 CYP1A2
9
Show member pathways
11.52 UGT2B7 CYP1B1 CYP1A2 CYP1A1
10
Show member pathways
11.46 SLCO1B3 CYP1B1 CYP1A1
11 11.42 CYP1B1 CYP1A2 CYP1A1
12 11.4 CYP1B1 CYP1A2 CYP1A1
13 11.36 HNF1A G6PC AFP
14 11.27 CYP1B1 CYP1A2 CYP1A1
15
Show member pathways
11.15 UGT2B7 CYP1B1 CYP1A2 CYP1A1
16 11.03 GSTP1 CYP1A2 CYP1A1
17
Show member pathways
11 UGT2B7 CYP1B1 CYP1A2 CYP1A1
18
Show member pathways
10.82 CYP1A2 CYP1A1
19
Show member pathways
10.79 SLCO1B3 SLCO1B1 CYP1A2 CYP1A1
20 10.72 CTNNB1 CDH1
21 10.66 CYP1B1 CYP1A2 CYP1A1
22
Show member pathways
10.63 CYP1B1 CYP1A2
23 10.53 UGT2B7 CYP1A2
24
Show member pathways
10.46 UGT2B7 CYP1B1 CYP1A2 CYP1A1

GO Terms for Hepatocellular Adenoma

Cellular components related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.86 SREBF1 SLC37A4 GLUL G6PC CYP1B1 CYP1A2
2 endoplasmic reticulum membrane GO:0005789 9.7 UGT2B7 SREBF1 SLC37A4 G6PC CYP1B1 CYP1A2
3 flotillin complex GO:0016600 9.32 CTNNB1 CDH1
4 organelle membrane GO:0031090 9.26 UGT2B7 CYP1B1 CYP1A2 CYP1A1
5 intracellular membrane-bounded organelle GO:0043231 9.23 UGT2B7 SREBF1 SLC37A4 GLUL G6PC CYP1B1

Biological processes related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10.04 UGT2B7 SREBF1 CYP1B1 CYP1A2 CYP1A1
2 regulation of gene expression GO:0010468 9.92 G6PC CYP1A2 CTNNB1 CDH1
3 response to organic cyclic compound GO:0014070 9.83 SREBF1 SLC37A4 CYP1A2 CYP1A1
4 cholesterol metabolic process GO:0008203 9.81 SREBF1 HNF1A CYP1A2
5 xenobiotic metabolic process GO:0006805 9.81 GSTP1 CYP1B1 CYP1A2
6 response to organic substance GO:0010033 9.8 CYP1A2 CYP1A1 CDH1
7 liver development GO:0001889 9.8 HNF1A CYP1A1 ASS1
8 response to estradiol GO:0032355 9.8 GSTP1 CYP1A2 CTNNB1 ASS1
9 response to drug GO:0042493 9.8 SREBF1 CYP1A2 CYP1A1 CTNNB1 CDH1 ASS1
10 lung development GO:0030324 9.78 SREBF1 GPC3 CYP1A2 CTNNB1
11 retinol metabolic process GO:0042572 9.73 CYP1B1 CYP1A2 CYP1A1
12 glycogen metabolic process GO:0005977 9.72 SLC37A4 IL6ST G6PC
13 bile acid and bile salt transport GO:0015721 9.69 SLCO1B3 SLCO1B1 HNF1A
14 response to glucose GO:0009749 9.67 SREBF1 SLC37A4 HNF1A GLUL
15 response to food GO:0032094 9.63 SREBF1 G6PC CYP1A1
16 hydrogen peroxide biosynthetic process GO:0050665 9.61 CYP1A2 CYP1A1
17 entry of bacterium into host cell GO:0035635 9.61 CTNNB1 CDH1
18 epoxygenase P450 pathway GO:0019373 9.61 CYP1B1 CYP1A2 CYP1A1
19 heterocycle metabolic process GO:0046483 9.6 CYP1A2 CYP1A1
20 glucose-6-phosphate transport GO:0015760 9.59 SLC37A4 G6PC
21 cellular response to indole-3-methanol GO:0071681 9.58 CTNNB1 CDH1
22 porphyrin-containing compound metabolic process GO:0006778 9.58 CYP1A2 CYP1A1
23 estrogen metabolic process GO:0008210 9.58 CYP1B1 CYP1A2 CYP1A1
24 cellular aromatic compound metabolic process GO:0006725 9.57 CYP1B1 CYP1A2
25 dibenzo-p-dioxin metabolic process GO:0018894 9.54 CYP1A2 CYP1A1
26 omega-hydroxylase P450 pathway GO:0097267 9.43 CYP1B1 CYP1A2 CYP1A1
27 response to toxic substance GO:0009636 9.35 GSTP1 CYP1B1 CYP1A1 CDH1 ASS1
28 toxin metabolic process GO:0009404 9.33 CYP1B1 CYP1A2 CYP1A1
29 steroid metabolic process GO:0008202 9.17 UGT2B7 SREBF1 SLC37A4 G6PC CYP1B1 CYP1A2

Molecular functions related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.58 CYP1B1 CYP1A2 CYP1A1
2 monooxygenase activity GO:0004497 9.5 CYP1B1 CYP1A2 CYP1A1
3 bile acid transmembrane transporter activity GO:0015125 9.43 SLCO1B3 SLCO1B1
4 demethylase activity GO:0032451 9.37 CYP1A2 CYP1A1
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.33 CYP1B1 CYP1A2 CYP1A1
6 estrogen 2-hydroxylase activity GO:0101021 9.26 CYP1A2 CYP1A1
7 aromatase activity GO:0070330 9.13 CYP1B1 CYP1A2 CYP1A1
8 estrogen 16-alpha-hydroxylase activity GO:0101020 8.8 CYP1B1 CYP1A2 CYP1A1

Sources for Hepatocellular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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