MCID: HPT067
MIFTS: 45

Hepatocellular Adenoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatocellular Adenoma

MalaCards integrated aliases for Hepatocellular Adenoma:

Name: Hepatocellular Adenoma 12 60 15 17 74

Characteristics:

Orphanet epidemiological data:

60
hepatocellular adenoma
Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:0050868
MESH via Orphanet 46 D018248
ICD10 via Orphanet 35 D13.4
UMLS via Orphanet 75 C0206669
Orphanet 60 ORPHA54272
UMLS 74 C0206669

Summaries for Hepatocellular Adenoma

Disease Ontology : 12 A liver benign neoplasm that is located in liver cells and that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards based summary : Hepatocellular Adenoma is related to hepatic adenomas, familial and hepatocellular carcinoma. An important gene associated with Hepatocellular Adenoma is GLUL (Glutamate-Ammonia Ligase), and among its related pathways/superpathways are Metabolism and Drug metabolism - cytochrome P450. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 77 Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It... more...

Related Diseases for Hepatocellular Adenoma

Diseases related to Hepatocellular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 hepatic adenomas, familial 32.7 CTNNB1 G6PC HNF1A
2 hepatocellular carcinoma 29.2 CTNNB1 CYP1A1 G6PC GLUL GSTP1 HNF1A
3 adenoma 11.0
4 glycogen storage disease 10.4
5 glycogen storage disease ia 10.2
6 glycogen storage disease due to glucose-6-phosphatase deficiency 10.2
7 familial adenomatous polyposis 10.1
8 noonan syndrome 10 10.1 G6PC GLUL
9 amyloidosis 10.0
10 liver disease 9.9
11 polycystic ovary syndrome 9.9
12 hemosiderosis 9.9
13 fatty liver disease 9.9
14 amyloidosis aa 9.9
15 danubian endemic familial nephropathy 9.9 CYP1A1 CYP1A2
16 gastroschisis 9.8 CYP1A1 CYP1A2
17 fanconi anemia, complementation group a 9.8
18 budd-chiari syndrome 9.8
19 cholangitis, primary sclerosing 9.8
20 beta-thalassemia 9.8
21 deficiency anemia 9.8
22 hepatitis 9.8
23 hepatitis b 9.8
24 islet cell tumor 9.8
25 thalassemia 9.8
26 thrombosis 9.8
27 nonalcoholic fatty liver disease 9.8
28 castleman disease 9.8
29 glucose intolerance 9.8
30 portal vein thrombosis 9.8
31 iron deficiency anemia 9.8
32 gender identity disorder 9.8
33 sclerosing cholangitis 9.8
34 iron metabolism disease 9.8
35 endometriosis 9.8
36 fibrolamellar carcinoma 9.8
37 hepatoblastoma 9.8
38 peliosis hepatis 9.8
39 cholangitis 9.8
40 congenital hepatic fibrosis 9.8
41 nodular regenerative hyperplasia 9.8
42 unicentric castleman disease 9.8
43 glycogen storage disease due to glycogen branching enzyme deficiency 9.8
44 renal dysplasia 9.8
45 clopidogrel resistance 9.7 CYP1A1 CYP1A2
46 acetaminophen metabolism 9.5 CYP1A1 CYP1A2 GSTP1

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to Hepatocellular Adenoma

Symptoms & Phenotypes for Hepatocellular Adenoma

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 ASS1 CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC
2 liver/biliary system MP:0005370 9.81 CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC GLUL
3 mortality/aging MP:0010768 9.61 ASS1 CTNNB1 CYP1A1 CYP1A2 G6PC GLUL
4 normal MP:0002873 9.1 ASS1 CTNNB1 CYP1A1 G6PC GLUL IL6ST

Drugs & Therapeutics for Hepatocellular Adenoma

Drugs for Hepatocellular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Not Applicable 329-65-7 838
2
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
3 Liver Extracts Not Applicable
4 Epinephryl borate Not Applicable
5 Hemostatics Not Applicable
6 Coagulants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Contrast Enhanced Ultrasound Compared to MRI for Differentiation of Hepatic Lesions Recruiting NCT03652636 Not Applicable
2 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

Anatomical Context for Hepatocellular Adenoma

MalaCards organs/tissues related to Hepatocellular Adenoma:

42
Liver, Bone, Bone Marrow, Placenta, Ovary, Brain, Uterus

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatocellular Adenoma:

20
Liver Cells

Publications for Hepatocellular Adenoma

Articles related to Hepatocellular Adenoma:

(show top 50) (show all 289)
# Title Authors Year
1
The effect of oral contraceptive pill cessation on hepatocellular adenoma diameter: a retrospective cohort study. ( 30773766 )
2019
2
Inflammatory hepatocellular adenoma in a patient with Turner's syndrome: A case report. ( 30798096 )
2019
3
Two Cases of Inflammatory Hepatocellular Adenoma with Elevated Serum Protein Induced by Vitamin K Absence/Antagonist-II in Adult Males. ( 30799343 )
2019
4
Ultrasound Imaging of Hepatocellular Adenoma Using the New Histology Classification. ( 30396597 )
2019
5
Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance. ( 29116626 )
2018
6
Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma. ( 29740826 )
2018
7
Hepatocellular adenoma in a woman who was undergoing testosterone treatment for gender identity disorder. ( 29589251 )
2018
8
New MRI features improve subtype classification of hepatocellular adenoma. ( 30523457 )
2018
9
Value of Texture Analysis on Gadoxetic Acid-Enhanced MRI for Differentiating Hepatocellular Adenoma From Focal Nodular Hyperplasia. ( 30557050 )
2018
10
Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice. ( 30572783 )
2018
11
Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report. ( 30596615 )
2018
12
OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy. ( 30218633 )
2018
13
Systemic AA Amyloidosis Caused by Inflammatory Hepatocellular Adenoma. ( 30231230 )
2018
14
Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia. ( 30252977 )
2018
15
Evaluation of texture analysis for the differential diagnosis of focal nodular hyperplasia from hepatocellular adenoma on contrast-enhanced CT images. ( 30267107 )
2018
16
Contrast-enhanced ultrasound patterns of hepatocellular adenoma: an Italian multicenter experience. ( 30306412 )
2018
17
Liver atoll sign: Inflammatory hepatocellular adenoma. ( 30309147 )
2018
18
Regression of hepatocellular adenoma after bariatric surgery in severe obese patients. ( 30025198 )
2018
19
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. ( 30052636 )
2018
20
Spontaneous hemoperitoneum in pregnancy caused by a hepatocellular adenoma, accompanied by fetal death. ( 30082185 )
2018
21
A difficult case of β-catenin-mutated hepatocellular adenoma: a lesson for diagnosis. ( 30184258 )
2018
22
Snapshot summary of diagnosis and management of hepatocellular adenoma subtypes. ( 30213653 )
2018
23
Molecular classification of hepatocellular adenoma in clinical practice. ( 28733222 )
2017
24
Intravoxel incoherent motion and dynamic contrast-enhanced MRI for differentiation between hepatocellular adenoma and focal nodular hyperplasia. ( 28590780 )
2017
25
Quantitative analysis Of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of LLCER method using gadobenate dimeglumine as contrast agent. ( 28589549 )
2017
26
Screening the key genes of hepatocellular adenoma via microarray analysis of DNA expression and methylation profiles. ( 28943905 )
2017
27
A cost-effectiveness analysis of the diagnostic strategies for differentiating focal nodular hyperplasia from hepatocellular adenoma. ( 28726119 )
2017
28
Unexpected discovery of small HNF1I+-inactivated hepatocellular adenoma in pathological specimens from patients resected for liver tumours. ( 29265678 )
2017
29
Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1I+-inactivated variant. ( 28992889 )
2017
30
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma. ( 29127141 )
2017
31
Management and outcome of hepatocellular adenoma with massive bleeding at presentation. ( 28740346 )
2017
32
Hepatocellular adenoma: Classification, variants and clinical relevance. ( 28131467 )
2017
33
Retrospective study on timing of resection of hepatocellular adenoma. ( 28857134 )
2017
34
Laparoscopic liver resection for hemorrhagic hepatocellular adenoma in a pregnant patient. ( 28982300 )
2017
35
Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination. ( 28323122 )
2017
36
Short-term outcomes of laparoscopic vs. open liver resection for hepatocellular adenoma: a multicenter propensity score adjustment analysis by the AFC-HCA-2013 study group. ( 28281121 )
2017
37
Argininosuccinate synthase 1 (ASS1): A marker of unclassified hepatocellular adenoma and high bleeding risk. ( 28646562 )
2017
38
Malignant potential of hepatocellular adenoma. ( 28635168 )
2017
39
Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia. ( 29281780 )
2017
40
Inflammatory and multiple hepatocellular adenoma are associated with a higher BMI. ( 28704224 )
2017
41
Correction to: Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? ( 29230554 )
2017
42
Hepatocellular adenoma in a European flatfish (Limanda limanda): Genetic alterations in laser-capture micro-dissected tissue and global transcriptomic approach. ( 28473212 )
2017
43
Expression of c-MET Protein in Various Subtypes of Hepatocellular Adenoma Compared to Hepatocellular Carcinoma and Non-Neoplastic Liver in Human Tissue. ( 29256857 )
2017
44
Diagnostic Value of Gd-EOB-DTPA-MRI for Hepatocellular Adenoma: A Meta-Analysis. ( 28607606 )
2017
45
Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? ( 29110059 )
2017
46
Men with biopsy-confirmed hepatocellular adenoma have a high risk of progression to hepatocellular carcinoma: AA nationwide population-based study. ( 28317318 )
2017
47
Response to "Quantitative analysis of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of llcer method using gadobenate dimeglumine as contrast agent". ( 28580722 )
2017
48
Systematic review: benefits and harms of transarterial embolisation for treating hepatocellular adenoma. ( 28318052 )
2017
49
Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat. ( 28190927 )
2017
50
Hepatocellular adenoma: imaging review of the various molecular subtypes. ( 28126185 )
2017

Variations for Hepatocellular Adenoma

Expression for Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for Hepatocellular Adenoma

Pathways related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 ASS1 CYP1A1 CYP1A2 FABP1 G6PC GLUL
2
Show member pathways
12.56 CYP1A1 CYP1A2 GSTP1 UGT2B7
3 11.83 ASS1 CTNNB1 GSTP1
4 11.81 CTNNB1 HNF1A IL6ST
5 11.77 CTNNB1 HNF1A IL6ST
6 11.51 ASS1 CYP1A2 FABP1 GLUL HNF1A
7
Show member pathways
11.44 CYP1A1 CYP1A2 GSTP1
8
Show member pathways
11.32 CYP1A1 CYP1A2 UGT2B7
9 11.25 CTNNB1 HNF1A
10 11.22 G6PC HNF1A
11 11.14 CYP1A1 CYP1A2
12 11.1 ASS1 GLUL
13
Show member pathways
11.02 CYP1A1 CYP1A2 UGT2B7
14
Show member pathways
10.96 ASS1 GLUL
15
Show member pathways
10.9 CYP1A1 CYP1A2
16
Show member pathways
10.86 CYP1A1 CYP1A2 UGT2B7
17
Show member pathways
10.66 CYP1A1 CYP1A2
18 10.55 CYP1A1 CYP1A2
19 10.51 CYP1A1 CYP1A2 GSTP1

GO Terms for Hepatocellular Adenoma

Cellular components related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 ASS1 CTNNB1 FABP1 GLUL GSTP1 IL6ST
2 protein-containing complex GO:0032991 9.56 CTNNB1 FABP1 GLUL HNF1A
3 intracellular membrane-bounded organelle GO:0043231 9.35 CYP1A1 CYP1A2 G6PC GLUL UGT2B7
4 transcription factor complex GO:0005667 9.33 CTNNB1 HNF1A MLXIPL
5 organelle membrane GO:0031090 8.8 CYP1A1 CYP1A2 UGT2B7

Biological processes related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 CTNNB1 FABP1 GSTP1 IL6ST
2 regulation of gene expression GO:0010468 9.79 CTNNB1 CYP1A2 G6PC
3 response to drug GO:0042493 9.78 ASS1 CTNNB1 CYP1A1 CYP1A2
4 response to lipopolysaccharide GO:0032496 9.74 ASS1 CYP1A1 CYP1A2
5 glucose homeostasis GO:0042593 9.69 G6PC HNF1A MLXIPL
6 response to toxic substance GO:0009636 9.67 ASS1 CYP1A1 GSTP1
7 cellular amino acid biosynthetic process GO:0008652 9.63 ASS1 GLUL
8 glycogen metabolic process GO:0005977 9.62 G6PC IL6ST
9 response to amino acid GO:0043200 9.61 ASS1 GSTP1
10 pancreas development GO:0031016 9.6 CTNNB1 HNF1A
11 cellular response to copper ion GO:0071280 9.59 CYP1A1 CYP1A2
12 drug metabolic process GO:0017144 9.58 CYP1A1 CYP1A2
13 response to immobilization stress GO:0035902 9.58 CYP1A1 CYP1A2
14 liver development GO:0001889 9.58 ASS1 CYP1A1 HNF1A
15 bone resorption GO:0045453 9.56 CTNNB1 HNF1A
16 long-chain fatty acid biosynthetic process GO:0042759 9.55 CYP1A1 CYP1A2
17 response to food GO:0032094 9.54 CYP1A1 G6PC
18 epoxygenase P450 pathway GO:0019373 9.52 CYP1A1 CYP1A2
19 omega-hydroxylase P450 pathway GO:0097267 9.46 CYP1A1 CYP1A2
20 toxin metabolic process GO:0009404 9.43 CYP1A1 CYP1A2
21 hydrogen peroxide biosynthetic process GO:0050665 9.37 CYP1A1 CYP1A2
22 heterocycle metabolic process GO:0046483 9.32 CYP1A1 CYP1A2
23 porphyrin-containing compound metabolic process GO:0006778 9.26 CYP1A1 CYP1A2
24 steroid metabolic process GO:0008202 9.26 CYP1A1 CYP1A2 G6PC UGT2B7
25 dibenzo-p-dioxin metabolic process GO:0018894 9.16 CYP1A1 CYP1A2
26 response to estradiol GO:0032355 8.92 ASS1 CTNNB1 CYP1A2 GSTP1

Molecular functions related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP1A1 CYP1A2
2 aromatase activity GO:0070330 8.96 CYP1A1 CYP1A2
3 demethylase activity GO:0032451 8.62 CYP1A1 CYP1A2

Sources for Hepatocellular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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