HCC
MCID: HPT023
MIFTS: 99

Hepatocellular Carcinoma (HCC)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatocellular Carcinoma

MalaCards integrated aliases for Hepatocellular Carcinoma:

Name: Hepatocellular Carcinoma 57 12 75 59 74 37 29 55 6 15 38 17
Liver Cancer 57 12 74 43 15
Primary Liver Cancer 12 53 15
Liver Neoplasms 75 44 72
Hepatoma 57 12 74
Hcc 57 59 74
Rare Tumor of Liver and Intrahepatic Biliary Tract 53 59
Primary Malignant Neoplasm of Liver 12 72
Malignant Neoplasm of Liver 12 72
Hepatoblastoma, Somatic 57 13
Cancer, Hepatocellular 57 40
Liver Cell Carcinoma 57 74
Hepatic Cancer 12 55
Hepatoblastoma 59 72
Lcc 57 74
Malignant Neoplasm of Liver, Not Specified As Primary or Secondary 12
Hepatocellular Carcinoma, Childhood Type, Somatic 57
Non-Resectable Primary Hepatic Malignant Neoplasm 12
Liver and Intrahepatic Biliary Tract Carcinoma 72
Resectable Malignant Neoplasm of the Liver 12
Adult Primary Hepatocellular Carcinoma 72
Resectable Malignant Neoplasm of Liver 12
Malignant Neoplasm of Liver, Primary 12
Hepatocellular Carcinoma, Somatic 57
Malignant Hepato-Biliary Neoplasm 12
Primary Malignant Liver Neoplasm 53
Malignant Hepatobiliary Neoplasm 72
Hepatocellular Cancer, Somatic 57
Rare Tumor of Liver and Ibt 59
Primary Tumor of the Liver 53
Liver Cell Carcinoma; Lcc 57
Carcinoma, Hepatocellular 44
Malignant Tumor of Liver 12
Primary Cancer of Liver 53
Primary Liver Carcinoma 53
Hepatocellular Cancer 74
Neoplasm of the Liver 6
Ca Liver - Primary 12
Neoplasm of Liver 12
Hepatic Neoplasm 12
Liver Carcinoma 72
Liver Neoplasm 17
Hepatomas 15

Characteristics:

Orphanet epidemiological data:

59
hepatocellular carcinoma
Inheritance: Not applicable; Prevalence: 1-9/100000 (United States),1-5/10000 (Europe); Age of onset: All ages; Age of death: adult;
hepatoblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Childhood,Infancy,Neonatal; Age of death: early childhood,infantile;

OMIM:

57
Inheritance:
somatic mutation

Miscellaneous:
genetic heterogeneity


HPO:

32
hepatocellular carcinoma:
Inheritance autosomal dominant inheritance somatic mutation heterogeneous


Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:3571 DOID:684
OMIM 57 114550
KEGG 37 H00048
ICD9CM 35 155.0 155.2
SNOMED-CT 68 93870000 95214007
ICD10 33 C22.0 C22.9
MESH via Orphanet 45 D006528 D018197
ICD10 via Orphanet 34 C22.0 C22.2
UMLS via Orphanet 73 C0023903 C0206624 C2239176
UMLS 72 C0023903 C0024620 C0206624 more

Summaries for Hepatocellular Carcinoma

MedlinePlus : 43 Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver. Risk factors for primary liver cancer include Having hepatitis B or C Heavy alcohol use Having cirrhosis, or scarring of the liver Having hemochromatosis, an iron storage disease Obesity and diabetes Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or liver transplantation. NIH: National Cancer Institute

MalaCards based summary : Hepatocellular Carcinoma, also known as liver cancer, is related to adult hepatocellular carcinoma and colorectal cancer, and has symptoms including nausea and vomiting, constipation and fever. An important gene associated with Hepatocellular Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Hepatocellular carcinoma and Viral carcinogenesis. The drugs Pravastatin and Propranolol have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells, and related phenotypes are hepatomegaly and portal hypertension

Disease Ontology : 12 A liver carcinoma that has material basis in undifferentiated hepatocytes and located in the liver.

OMIM : 57 Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common cancer and the third most common cause of death from cancer worldwide. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Hepatoblastomas comprise 1 to 2% of all malignant neoplasms of childhood, most often occurring in children under 3 years of age. Hepatoblastomas are thought to be derived from undifferentiated hepatocytes (Taniguchi et al., 2002). (114550)

KEGG : 37
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.

UniProtKB/Swiss-Prot : 74 Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Wikipedia : 75 Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the... more...

Related Diseases for Hepatocellular Carcinoma

Diseases in the Hepatocellular Carcinoma family:

Adult Hepatocellular Carcinoma

Diseases related to Hepatocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1576)
# Related Disease Score Top Affiliating Genes
1 adult hepatocellular carcinoma 36.9 TP53 PIK3CA PDGFRL CTNNB1 CASP8 AXIN1
2 colorectal cancer 35.0 TP53 TERT PIK3CA PDGFRL NRAS NFE2L2
3 cholangiocarcinoma 34.8 TP53 TERT PIK3CA MIR21 MET KRAS
4 breast cancer 34.7 TP53 TERT PIK3CA MIR21 MIR122 MET
5 lung cancer susceptibility 3 34.3 TP53 TERT PIK3CA NRAS NFE2L2 MET
6 intrahepatic cholangiocarcinoma 34.2 TP53 KRAS IDH2 IDH1 CTNNB1
7 gastric cancer 34.0 TP53 TERT PIK3CA MIR21 MIR122 MET
8 adenocarcinoma 34.0 TP53 PIK3CA KRAS HRAS FGFR1 CTNNB1
9 prostate cancer 33.9 TP53 TERT PIK3CA MIR21 MET KRAS
10 lung cancer 33.8 TP53 TERT PIK3CA NRAS MIR21 MET
11 esophageal cancer 33.7 TP53 TERT PIK3CA MIR21 KRAS HRAS
12 adenoma 33.7 TP53 KRAS CTNNB1 APC
13 leukemia, acute myeloid 33.7 TP53 TERT NRAS MIR21 KRAS IDH2
14 glioblastoma 33.7 TP53 PIK3CA NRAS MIR21 MET IDH2
15 gastric adenocarcinoma 33.6 TP53 PIK3CA NRAS MET KRAS HRAS
16 pancreatic cancer 33.6 TP53 PIK3CA MIR21 MET KRAS HRAS
17 large intestine cancer 33.4 TP53 TERT PIK3CA NRAS MET KRAS
18 myeloma, multiple 33.3 TP53 NRAS KRAS IDH2 IDH1 HRAS
19 glioma 33.3 TP53 PIK3CA MIR21 MIR17 MET IDH2
20 cervical cancer 33.3 TP53 TERT PIK3CA NFE2L2 MIR21 HRAS
21 medulloblastoma 33.3 TP53 TERT PIK3CA NRAS MIR17 IDH1
22 familial adenomatous polyposis 33.2 TP53 KRAS CTNNB1 AXIN1 APC
23 bladder urothelial carcinoma 33.0 TP53 PIK3CA NRAS NFE2L2 KRAS IDH1
24 ovarian cancer 33.0 TP53 TERT PIK3CA MIR21 KRAS CTNNB1
25 hepatoblastoma 33.0 TP53 CTNNB1 APC
26 glioblastoma multiforme 33.0 TP53 PIK3CA MIR21 MET IDH1
27 brain cancer 33.0 TP53 TERT PIK3CA NRAS IDH2 IDH1
28 nasopharyngeal carcinoma 33.0 TP53 TERT PIK3CA NRAS HRAS
29 myelodysplastic syndrome 33.0 TP53 TERT NRAS KRAS IDH2 IDH1
30 bladder cancer 32.9 TP53 TERT MIR21 KRAS HRAS
31 sarcoma 32.9 TP53 PIK3CA KRAS HRAS CTNNB1
32 gallbladder cancer 32.8 TP53 TERT PIK3CA KRAS
33 kidney cancer 32.8 TP53 MIR21 MIR17 MIR122 MET
34 colorectal adenocarcinoma 32.8 TP53 KRAS HRAS CTNNB1
35 lymphoma, non-hodgkin, familial 32.6 TP53 PIK3CA NRAS CASP8
36 gastrointestinal system cancer 32.6 TP53 PIK3CA MET KRAS HRAS CTNNB1
37 breast adenocarcinoma 32.6 TP53 PIK3CA KRAS CASP8
38 liver angiosarcoma 32.6 TP53 NRAS KRAS HRAS
39 leukemia, chronic lymphocytic 32.6 TP53 NRAS KRAS HRAS CASP8
40 adenoid cystic carcinoma 32.6 TP53 PIK3CA KRAS IDH1 HRAS CTNNB1
41 adrenocortical carcinoma, hereditary 32.5 TP53 PIK3CA NRAS CTNNB1
42 myeloid leukemia 32.5 TP53 NRAS IDH1 HRAS
43 undifferentiated pleomorphic sarcoma 32.5 PIK3CA MET KRAS IDH2 IDH1
44 colon adenocarcinoma 32.5 CTNNB1 CASP8 APC KRAS
45 colorectal adenoma 32.5 TP53 KRAS HRAS CTNNB1 APC
46 carcinosarcoma 32.4 TP53 PIK3CA KRAS HRAS CTNNB1
47 cystadenocarcinoma 32.4 TP53 PIK3CA HRAS
48 ovary adenocarcinoma 32.4 TP53 PIK3CA KRAS HRAS
49 melanoma, cutaneous malignant 1 32.4 TP53 TERT PIK3CA NRAS HRAS CTNNB1
50 lung squamous cell carcinoma 32.3 TP53 PIK3CA NFE2L2 KRAS HRAS FGFR1

Comorbidity relations with Hepatocellular Carcinoma via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alcoholic Liver Cirrhosis Deficiency Anemia
Hepatic Encephalopathy Intrahepatic Gall Duct Cancer
Portal Hypertension Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Hepatocellular Carcinoma:



Diseases related to Hepatocellular Carcinoma

Symptoms & Phenotypes for Hepatocellular Carcinoma

Human phenotypes related to Hepatocellular Carcinoma:

59 32 (show all 50)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hepatomegaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0002240
2 portal hypertension 59 32 hallmark (90%) Very frequent (99-80%) HP:0001409
3 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
4 hyperbilirubinemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002904
5 hypoalbuminemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003073
6 type ii diabetes mellitus 59 32 frequent (33%) Frequent (79-30%) HP:0005978
7 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
8 abnormality of the rectum 59 32 frequent (33%) Frequent (79-30%) HP:0002034
9 elevated hepatic transaminase 59 32 frequent (33%) Frequent (79-30%) HP:0002910
10 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
11 esophageal varix 59 32 frequent (33%) Frequent (79-30%) HP:0002040
12 venous insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0005293
13 abdominal distention 59 32 frequent (33%) Frequent (79-30%) HP:0003270
14 epigastric pain 59 32 frequent (33%) Frequent (79-30%) HP:0410019
15 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
16 hypokalemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002900
17 fatigue 59 32 occasional (7.5%) Occasional (29-5%) HP:0012378
18 dyspnea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002094
19 hypoglycemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001943
20 ascites 59 32 occasional (7.5%) Occasional (29-5%) HP:0001541
21 anemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001903
22 neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0002664
23 thrombocytopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001873
24 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952
25 thrombocytosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001894
26 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
27 hypercalcemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003072
28 diarrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002014
29 bone pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0002653
30 internal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0011029
31 polycythemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001901
32 poor appetite 59 32 occasional (7.5%) Occasional (29-5%) HP:0004396
33 anasarca 59 32 occasional (7.5%) Occasional (29-5%) HP:0012050
34 metabolic alkalosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0200114
35 hepatic encephalopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002480
36 mood changes 59 32 occasional (7.5%) Occasional (29-5%) HP:0001575
37 hepatic necrosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002605
38 hemobilia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100762
39 pedal edema 32 occasional (7.5%) HP:0010741
40 hypotension 59 32 very rare (1%) Very rare (<4-1%) HP:0002615
41 liver abscess 59 32 very rare (1%) Very rare (<4-1%) HP:0100523
42 budd-chiari syndrome 59 32 very rare (1%) Very rare (<4-1%) HP:0002639
43 abnormality of the liver 59 Very frequent (99-80%)
44 edema of the lower limbs 59 Occasional (29-5%)
45 hepatocellular carcinoma 32 HP:0001402
46 micronodular cirrhosis 32 HP:0001413
47 constitutional symptom 59 Occasional (29-5%)
48 abnormality of the hepatic vasculature 59 Very frequent (99-80%)
49 abnormality of glycoprotein metabolism 59 Occasional (29-5%)
50 subacute progressive viral hepatitis 32 HP:0006572

Symptoms via clinical synopsis from OMIM:

57
Abdomen Liver:
hepatocellular carcinoma
micronodular cirrhosis
subacute progressive viral hepatitis

Laboratory Abnormalities:
often integrated hbv sequences in hepatocellular carcinomas

Neoplasia:
primary liver cancer

Clinical features from OMIM:

114550

UMLS symptoms related to Hepatocellular Carcinoma:


nausea and vomiting, constipation, fever, abdominal pain, diarrhea, hepatosplenomegaly, icterus, dyspepsia, heartburn, gastrointestinal gas, malaise

GenomeRNAi Phenotypes related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.05 HRAS KRAS PIK3CA
2 Decreased viability GR00106-A-0 10.05 KRAS
3 Decreased viability GR00221-A-1 10.05 FGFR1 HRAS KRAS NRAS PDGFRL PIK3CA
4 Decreased viability GR00221-A-2 10.05 FGFR1 HRAS KRAS PIK3CA
5 Decreased viability GR00221-A-3 10.05 HRAS NRAS
6 Decreased viability GR00221-A-4 10.05 PIK3CA
7 Decreased viability GR00301-A 10.05 KRAS
8 Decreased viability GR00381-A-1 10.05 KRAS
9 Decreased viability GR00402-S-2 10.05 FGFR1 HRAS KRAS NRAS PDGFRL PIK3CA
10 Decreased cell migration GR00055-A-1 9.55 CTNNB1 HRAS KRAS MET PIK3CA
11 Increased cell migration GR00055-A-3 8.92 CTNNB1 HRAS KRAS PIK3CA

MGI Mouse Phenotypes related to Hepatocellular Carcinoma:

46 (show all 27)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 APC AXIN1 CASP8 CTNNB1 FGFR1 HRAS
2 growth/size/body region MP:0005378 10.47 APC AXIN1 CASP8 CTNNB1 FGFR1 HRAS
3 cellular MP:0005384 10.44 APC AXIN1 CASP8 CTNNB1 FGFR1 IGF2R
4 behavior/neurological MP:0005386 10.41 APC AXIN1 CTNNB1 FGFR1 HRAS IGF2R
5 homeostasis/metabolism MP:0005376 10.41 APC CASP8 CTNNB1 FGFR1 HRAS IDH1
6 mortality/aging MP:0010768 10.39 APC AXIN1 CASP8 CTNNB1 FGFR1 HRAS
7 embryo MP:0005380 10.38 APC AXIN1 CASP8 CTNNB1 FGFR1 IGF2R
8 endocrine/exocrine gland MP:0005379 10.38 APC CASP8 CTNNB1 FGFR1 HRAS IGF2R
9 craniofacial MP:0005382 10.36 APC AXIN1 CTNNB1 FGFR1 HRAS IGF2R
10 digestive/alimentary MP:0005381 10.35 APC AXIN1 CTNNB1 FGFR1 HRAS KRAS
11 immune system MP:0005387 10.34 APC CASP8 CTNNB1 FGFR1 IDH1 KRAS
12 hematopoietic system MP:0005397 10.32 APC CASP8 CTNNB1 FGFR1 IDH1 IGF2R
13 nervous system MP:0003631 10.27 APC AXIN1 CASP8 CTNNB1 FGFR1 HRAS
14 neoplasm MP:0002006 10.26 APC CASP8 CTNNB1 HRAS IDH2 KRAS
15 integument MP:0010771 10.25 APC CASP8 CTNNB1 FGFR1 HRAS KRAS
16 limbs/digits/tail MP:0005371 10.19 APC AXIN1 CTNNB1 FGFR1 IGF2R KRAS
17 liver/biliary system MP:0005370 10.18 APC CASP8 CTNNB1 IGF2R KRAS MET
18 normal MP:0002873 10.18 APC AXIN1 CTNNB1 FGFR1 HRAS IGF2R
19 muscle MP:0005369 10.1 APC CASP8 CTNNB1 FGFR1 KRAS MET
20 hearing/vestibular/ear MP:0005377 10.06 APC AXIN1 CTNNB1 FGFR1 KRAS TP53
21 renal/urinary system MP:0005367 10.06 APC AXIN1 CASP8 CTNNB1 FGFR1 HRAS
22 no phenotypic analysis MP:0003012 10.03 CTNNB1 FGFR1 HRAS KRAS MET NRAS
23 reproductive system MP:0005389 9.91 APC AXIN1 CTNNB1 FGFR1 IGF2R KRAS
24 respiratory system MP:0005388 9.9 AXIN1 CASP8 CTNNB1 HRAS IDH1 IGF2R
25 pigmentation MP:0001186 9.77 APC CTNNB1 KRAS NRAS TP53
26 skeleton MP:0005390 9.77 APC AXIN1 CTNNB1 FGFR1 HRAS IDH1
27 vision/eye MP:0005391 9.23 APC CTNNB1 FGFR1 KRAS MET NRAS

Drugs & Therapeutics for Hepatocellular Carcinoma

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Ethiodized oil For use as a radio-opaque medium for hysterosalpingography and lymphography, and as an antineoplastic agent when part of the iodine is 131-I. It is also used in follow-up imaging for chemoembolization. DB00965

Drugs for Hepatocellular Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 790)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pravastatin Approved Phase 4 81093-37-0 54687
2
Propranolol Approved, Investigational Phase 4 525-66-6 4946
3
Tegafur Approved, Investigational Phase 4 17902-23-7 5386
4
acetic acid Approved Phase 4 64-19-7 176
5
Desflurane Approved Phase 4 57041-67-5 42113
6
Cefazolin Approved Phase 4 25953-19-9 656510 33255
7
Nadolol Approved Phase 4 42200-33-9 39147
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Ethanol Approved Phase 4 64-17-5 702
10
Iodine Approved, Investigational Phase 4 7553-56-2 807
11
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
12
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
13
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 23925 27284
14
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
15
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
16
Colchicine Approved Phase 4 64-86-8 6167 2833
17
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
18
Mycophenolic acid Approved Phase 4 24280-93-1 446541
19
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
20
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
21
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
22
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
24
Pantoprazole Approved Phase 4 102625-70-7 4679
25
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
26
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
27
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
28
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
29
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
30
Povidone Approved Phase 4 9003-39-8
31
Povidone-iodine Approved Phase 4 25655-41-8
32
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
33 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
34
Sargramostim Approved, Investigational Phase 4 83869-56-1, 123774-72-1
35
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
36
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
37
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
38
Norepinephrine Approved Phase 4 51-41-2 439260
39
Acetaminophen Approved Phase 4 103-90-2 1983
40
Azathioprine Approved Phase 4 446-86-6 2265
41
Adefovir dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
42
Nicotine Approved Phase 4 54-11-5 942 89594
43
Methadone Approved, Illicit Phase 4 76-99-3 4095
44
Cobicistat Approved Phase 4 1004316-88-4
45
Epirubicin Approved Phase 4 56420-45-2 41867
46
Coal tar Approved Phase 4 8007-45-2
47
Testosterone Approved, Experimental, Investigational Phase 4 481-30-1, 58-22-0 6013 10204
48
Velpatasvir Approved, Investigational Phase 4 1377049-84-7 67683363
49
Testosterone enanthate Approved Phase 4 315-37-7 9416
50
Methyltestosterone Approved Phase 4 58-18-4 6010

Interventional clinical trials:

(show top 50) (show all 3023)
# Name Status NCT ID Phase Drugs
1 Radiotherapy as an Adjuvant Therapy After Radiofrequency Ablation for Hepatocellular Carcinoma Unknown status NCT00557024 Phase 4
2 Nucleoid as an Adjuvant Therapy After Radiofrequency Ablation for Hepatocellular Carcinoma Unknown status NCT00555334 Phase 4 lamivudine or entecavir
3 An Randomized and Controlled Study of Hepatic Arterial Infusion of Oxaliplatin and Fluorouracil Treatment of Advanced Primary Liver Cancer After TACE Unknown status NCT02557503 Phase 4 Oxaliplatin and fluorouracil
4 Transcatheter Arterial Chemoembolization as an Adjuvant Therapy After Radiofrequency Ablation for Hepatocellular Carcinoma Unknown status NCT00556803 Phase 4
5 The Observation Of Safety And Survival Of Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization Combined With Anti-hepatitis B Virus Therapy Unknown status NCT01102335 Phase 4 Telbivudine
6 Transarterial Radioembolization Versus Chemoembolization for the Treatment of Advanced Hepatocellular Carcinoma Unknown status NCT02729506 Phase 4
7 A Clinical Trail of Iodine[131I] Metuximab Injection With CIK Cells for Preventing Relapse and Metastasis of Hepatocellular Carcinoma Unknown status NCT01758679 Phase 4
8 Efficacy of Antiviral Therapy With Lamivudine or Entecavir After Radical Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma Unknown status NCT00768157 Phase 4 antiviral treatment (lamivudine or entecavir)
9 Investigator Initiated Study of Thymosin in HBV-related HCC Unknown status NCT02281266 Phase 4 thymalfasin;nucleoside analog (suggest to use entecavir)
10 Radiofrequency Ablation With or With Transcatheter Arterial Embolization for Hepatocellular Carcinoma Unknown status NCT00554905 Phase 4
11 Hepatic Resection Versus Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Complicated by Portal Vein Tumor Thrombosis.A Prospective and Randomized Clinical Trial Unknown status NCT01350206 Phase 4
12 Radiofrequency Ablation for Small Hepatocellular Carcinoma Using Octopus Electrode and No-touch Technique: Preliminary Study Unknown status NCT02832882 Phase 4
13 Radiofrequency Ablation Using Dual Cooled-Wet Electrode for Small Hepatocellular Carcinoma With No-touch Technique: Preliminary Study Unknown status NCT02806076 Phase 4
14 The Response and Outcomes of Pegylated Interferon Plus Ribavirin Combination Therapy for Chronic Hepatitis C Patients Concomitant With Hepatocellular Carcinoma Unknown status NCT00834860 Phase 4 peginterferon alpha-2a and ribavirin
15 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With Hepatocellular Carcinoma Unknown status NCT01451658 Phase 4 propranolol
16 A Randomized Controled Trial of Oral S-1 in Combination With Sequential Hepatic Arterial Infusion of Oxaliplatin After Transarterial Chemoembolization in Patients With Advanced Hepatocellular Carcinoma Unknown status NCT01997957 Phase 4 S-1
17 Transcatheter Arterial Chemoembolization Combined With Sorafenib for Unresectable Hepatocellular Carcinoma Unknown status NCT01833299 Phase 4
18 A Phase 4, Open-Label Study to Investigate the Efficacy and Safety of Tenofovir Disoproxil Fumarate (Viread(R)) in Preventing Hepatocellular Carcinoma Recurrence in Chronic Hepatitis B Virus Infected Patients With Low Viral Load at Baseline Treated With Radiofrequency Ablation or Resection Unknown status NCT02308319 Phase 4 Tenofovir disoproxil fumarate
19 Endoscopic Treatment Versus Propranolol for Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Unknown status NCT01970748 Phase 4 Propranolol
20 A Prospective Randomized Control Study of Cidan Capsule Combined With Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma Unknown status NCT02253511 Phase 4 Cidan capsule
21 Trial of Ablation of Small Hepatocellular Carcinomas in Patients of Cirrhosis Unknown status NCT01438437 Phase 4
22 Chemoembolization With or Without Antiviral Therapy for Unresectable HBV-related Hepatocellular Carcinoma With Low HBV DNA Replication: Effectiveness and Safety. A Prospective and Randomized Clinical Trial Unknown status NCT01894269 Phase 4 Lamivudine 100mg once daily; or Entecavir 0.5mg once daily.
23 Study of the Relationship Between the Rate of Residual Platinum in the Blood and the Incidence of Persistent Neurotoxicity in Patients Treated for Gastrointestinal Cancer With Oxaliplatin Unknown status NCT00274885 Phase 4 oxaliplatin
24 Radiofrequency Ablation Versus Liver Resection for Elderly Patients With Hepatocellular Carcinoma (HCC) Within the Milan Criteria Unknown status NCT01570075 Phase 4
25 Radiofrequency Ablation Combined With Transcatheter Arterial Chemoembolization Versus Radiofrequency Ablation Alone for Recurrent Hepatocellular Carcinoma Unknown status NCT01415063 Phase 4
26 Effects of Different Inhalational Anesthetic Agents on the Incidence of Clinical and Subclinical Acute Kidney Injury After Liver Resection Surgery: a Pilot Study Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
27 Improving Cone-beam Computed Tomography for Image Guided Stereotactic Body Radiation Therapy of the Liver Using Gadoxetate Disodium Unknown status NCT03215355 Phase 4 Primovist
28 Radiofrequency Ablation vs. Hepatic Resection for the Treatment of Hepatocellular Carcinomas Smaller Than 2 cm.A Prospective and Randomized Clinical Trial Unknown status NCT01351194 Phase 4
29 Use of Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis, Prediction of Clinical Outcome and Monitoring of Treatment Response to Neoadjuvant Chemotherapy Unknown status NCT01956409 Phase 4 18F-FCH;Magnevist
30 Prophylactic Administration of Antibiotics Before Radiofrequency Ablation for Hepatocellular Carcinoma: A Randomized Trial Unknown status NCT02534961 Phase 4 Cefazolin
31 A Prospective,Randomized Control Trial of Intraoperative Intraportal Chemotherapy (5-FU and Oxaliplatin) Combined With Adjuvant Chemotherapy to Prevent Liver Metastasis in Patients Receiving Curative Colorectal Cancer Resection. Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
32 Entecavir for Patients With Decompensated HBV-Related Cirrhosis:a Prospective Randomized Controlled Trial Unknown status NCT00663182 Phase 4 Entecavir
33 Phase IV Study of Effectiveness of Interferon and Ribavirin Treatment in Thalassemia Major Patients With Chronic Viral Hepatitis C Unknown status NCT00887081 Phase 4 PEG-IFN alpha2a or PEG-IFN alpha2b and Ribavirin
34 A Prospective, Multicenter, Open-labeled, Parallel -Controlled Clinical Study Investigating Huaier Granule for Prevention of Disease Progression of Hepatocarcinoma After Non-radical Hepatectomy Unknown status NCT01760616 Phase 4 Huaier Granule
35 Sustained Off-treatment Response After HBeAg Loss in HBeAg-Pos Chronic Hepatitis B Patients Treated With Nucleos(t)Ide Analogues Unknown status NCT01911156 Phase 4 Continue NA treatment;Discontinue NA Treatment
36 Study of New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
37 Branched-chain Amino Acid (BCAA) on Progression of Advanced Liver Disease (BRAVE): Korean Nation-wide Multicenter Retrospective and Prospective Observational Cohort Study Unknown status NCT02837302 Phase 4 Livact
38 The Effect of Branched-chain Amino Acid on the Improvement of Serum Albumin Level in Cirrhotic Patients With Ascites: A Multi-center, Randomized, Double-blind, Placebo-controlled, Investigator Initiated Clinical Trial Unknown status NCT02755701 Phase 4 Branched-chain Amino Acid;Placebo
39 Cholestatic Drug-induced Liver Injury: Correlation With Genotypes of UGT1A1 and 1A7, and Treatment Effect of Ursodeoxycholic Acid Unknown status NCT01141322 Phase 4 Ursodeoxycholic Acid;Placebo
40 TAC vs TACE Plus folfox4 as the Treatment of Unresectalbe Liver Metastasis of Colorectal Cancer With Resection of the Primary Tumor: a Prospective, Randomized, Control Trial Unknown status NCT00868569 Phase 4
41 A Randomized Tril of Endoscopic Cyanoacrylate Obliteration vs. Nadolol Unknown status NCT00567216 Phase 4 Nadolol
42 Randomized Controlled Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer Unknown status NCT01038154 Phase 4 Pravastatin
43 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With HCC:a Randomized Trial Unknown status NCT01298284 Phase 4 propranolol
44 Randomized Study Comparing Nucleoside Analogues Plus Tenofovir and Nucleoside Analogues Plus Adefovir in Chronic Hepatitis B Patients With Suboptimal Response to Adefovir-based Combination Therapy Due to Nucleoside Analogues Resistance Unknown status NCT01595633 Phase 4 Switching from adefovir (10mg/day) to tenofovir (300mg/day)
45 An Efficacy and Safety Study Comparing Pegylated-Interferon and Ribavirin Plus Metformin to Pegylated-Interferon and Ribavirin in the Treatment of naïve Patients With Genotype 1 Chronic HCV Infection and Insulin Resistance Unknown status NCT00370617 Phase 4 metformin
46 Phase IV Multi-Institutional Randomized Trial of Capecitabine Plus Oxaliplatin With Bevacizumab in Patients With Potentially Resectable Gastric Cancer With Liver Metastasis Unknown status NCT01962376 Phase 4 Oxaliplatin;Capecitabine;Oxaliplatin;Capecitabine;Bevacizumab
47 Randomized Clinical Trial of Omega-3 Fatty Acid-supplemented Parenteral Nutrition Versus Standard Parenteral Nutrition in Patients Undergoing Major Laparoscopic Abdominal Surgery Unknown status NCT01819961 Phase 4 MCT/LCT and fish oil;MCT/LCT
48 Phase IV Multi-Institutional Randomized Trial of Capecitabine Plus Oxaliplatin With Herceptin in Patients With Potentially Resectable HER-2 Positive Gastric Cancer With Liver Metastasis Unknown status NCT02380131 Phase 4 Oxaliplatin plus Capecitabine;Herceptin
49 A Randomized Controlled Trial of TACE Hepatic Artery Infusion of Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Unknown status NCT02557490 Phase 4 oxaliplatin and raltitrexed
50 Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease Unknown status NCT00941642 Phase 4 Lovaza;placebo control

Search NIH Clinical Center for Hepatocellular Carcinoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ethiodized oil
Interferon Alfa-2a
Interferon Alfa-2b
INTERFERON ALFA-3N,HUMAN LEUKOCYTE DERIVED
interferon alfacon-1
Interferon gamma-1b
Interferons
peginterferon alfa-2a
peginterferon alfa-2b
Recombinant interferon beta-1a
Recombinant interferon beta-1b
regorafenib
sorafenib

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hepatocellular Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatocellular Carcinoma:
Tumor infiltrating lymphocytes (TILs) for solid tumors
Embryonic/Adult Cultured Cells Related to Hepatocellular Carcinoma:
Tumor infiltrating lymphocytes PMIDs: 24329789 19342963 21498393 22996367 19304471 22555974 15800326 23650429 21325070 8170938 12242449 24218514 23904171

Cochrane evidence based reviews: liver neoplasms

Genetic Tests for Hepatocellular Carcinoma

Genetic tests related to Hepatocellular Carcinoma:

# Genetic test Affiliating Genes
1 Hepatocellular Carcinoma 29 APC AXIN1 CASP8 CTNNB1 IGF2R MET PDGFRL PIK3CA TP53

Anatomical Context for Hepatocellular Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatocellular Carcinoma:

19
Liver

MalaCards organs/tissues related to Hepatocellular Carcinoma:

41
Liver, T Cells, Lung, Testes, Endothelial, Bone, Breast

Publications for Hepatocellular Carcinoma

Articles related to Hepatocellular Carcinoma:

(show top 50) (show all 47479)
# Title Authors PMID Year
1
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. 9 8 71
15608678 2005
2
MicroRNA expression, survival, and response to interferon in liver cancer. 38 88 8
19812400 2009
3
Somatic mutations of the APC gene in sporadic hepatoblastomas. 8 71
8764128 1996
4
Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. 9 38 8
7892276 1995
5
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. 38 8
30814741 2019
6
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. 38 8
24578576 2014
7
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. 38 8
24047069 2013
8
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. 38 8
24047070 2013
9
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. 38 8
24047071 2013
10
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. 38 8
23758232 2013
11
Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. 38 8
22922871 2012
12
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. 38 8
21822264 2011
13
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 38 8
21499248 2011
14
Diet-induced hepatocellular carcinoma in genetically predisposed mice. 38 8
19454484 2009
15
Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. 38 8
19221438 2009
16
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. 38 8
18167406 2008
17
Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma. 38 8
12668613 2003
18
Molecular pathogenesis of human hepatocellular carcinoma. 38 8
12149612 2002
19
Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. 38 71
11466687 2001
20
Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas. 9 8
10779553 2000
21
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. 9 71
10700176 2000
22
Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity. 9 71
10435629 1999
23
Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma. 38 8
9589695 1998
24
Mutational hotspot in the p53 gene in human hepatocellular carcinomas. 9 71
1849234 1991
25
Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma. 38 8
2573067 1989
26
Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer. 38 8
2847975 1988
27
Sequences which flank an 11p deletion observed in an hepatocellular carcinoma map to 11p13. 38 8
3026949 1987
28
Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma. 38 8
2996131 1985
29
Fraternal hepatocellular carcinoma in young children in two families. 38 8
6321015 1984
30
Familial hepatocellular carcinoma in an endemic area of Thailand. 38 8
6317164 1984
31
Primary hepatocellular carcinoma in three male siblings. 38 8
4298178 1968
32
FRATERNAL PRIMARY HEPATOCELLULAR CARCINOMA IN THREE MALE, ADULT SIBLINGS. 38 8
14320698 1965
33
Management of adverse events associated with tyrosine kinase inhibitors: Improving outcomes for patients with hepatocellular carcinoma. 38 17
31195212 2019
34
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours. 71
26266975 2015
35
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. 71
26266985 2015
36
Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly. 71
23100325 2013
37
Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. 71
22658544 2012
38
Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. 71
22729222 2012
39
hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. 38 88
20924108 2010
40
microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. 38 88
20842113 2010
41
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. 8
20676096 2010
42
miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. 38 88
19843643 2010
43
Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. 38 88
20041405 2010
44
MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling. 38 88
20103675 2010
45
Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ia glycogen storage disease. 8
19762333 2009
46
MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma. 38 88
19863192 2009
47
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. 38 88
19726678 2009
48
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. 38 88
19617899 2009
49
Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. 38 88
19711427 2009
50
Identification of genes conferring resistance to 5-fluorouracil. 8
19622726 2009