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MCID: HPT011
MIFTS: 29

Hepatocellular Clear Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases
Genes Variations Tissues Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Hepatocellular Clear Cell Carcinoma

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MalaCards integrated aliases for Hepatocellular Clear Cell Carcinoma:

Name: Hepatocellular Clear Cell Carcinoma 12 15
Hepatocellular Carcinoma, Clear Cell Type 12
Clear Cell Carcinoma of the Liver Cells 12
Clear Cell Hepatocellular Carcinoma 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5016
NCIt 49 C5754
UMLS 71 C1333067
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Summaries for Hepatocellular Clear Cell Carcinoma

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MalaCards based summary : Hepatocellular Clear Cell Carcinoma, is also known as hepatocellular carcinoma, clear cell type, and has symptoms including fever, abdominal pain and icterus. An important gene associated with Hepatocellular Clear Cell Carcinoma is PNMT (Phenylethanolamine N-Methyltransferase), and among its related pathways/superpathways is Sterol Regulatory Element-Binding Proteins (SREBP) signalling. Affiliated tissues include liver, and related phenotypes are Decreased viability ratio and Increased HPV18 LCR reporter activity

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Related Diseases for Hepatocellular Clear Cell Carcinoma

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Symptoms & Phenotypes for Hepatocellular Clear Cell Carcinoma

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UMLS symptoms related to Hepatocellular Clear Cell Carcinoma:


fever, abdominal pain, icterus, malaise

GenomeRNAi Phenotypes related to Hepatocellular Clear Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability ratio GR00368-A 9.26 AFP AMFR PNMT TBPL2
2 Increased HPV18 LCR reporter activity GR00197-A-1 8.92 AFP TBPL2
3 Increased HPV18 LCR reporter activity GR00197-A-3 8.92 AFP TBPL2
Sources

Drugs & Therapeutics for Hepatocellular Clear Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Hepatocellular Clear Cell Carcinoma

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Genetic Tests for Hepatocellular Clear Cell Carcinoma

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Anatomical Context for Hepatocellular Clear Cell Carcinoma

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MalaCards organs/tissues related to Hepatocellular Clear Cell Carcinoma:

40
Liver
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Publications for Hepatocellular Clear Cell Carcinoma

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Articles related to Hepatocellular Clear Cell Carcinoma:

(show all 34)
# Title Authors PMID Year
1
A case of primary clear cell hepatocellular carcinoma comprised mostly of clear cells. 61
31695824 2019
2
Unusual isolated pelvic metastasis from a clear cell hepatocellular carcinoma demonstrated on 18F-FDG PET/CT after liver transplantation. 61
28434874 2018
3
Clear cell hepatocellular carcinoma: origin, metabolic traits and fate of glycogenotic clear and ground glass cells. 61
29291777 2017
4
Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma. 61
28460432 2017
5
IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing. 61
28403884 2017
6
Clear cell hepatocellular carcinoma diagnosed by bile duct brushing cytology. 61
26638110 2016
7
Clear cell hepatocellular carcinoma: Back to the basics for diagnosis. 61
26458650 2015
8
[Expression of carbonic anhydrase IX, PAX2 and PAX8 and their association with clinicopathologic characteristics in renal epithelial tumors]. 61
24246861 2013
9
[Clinicopathological and prognostic analysis of primary clear cell carcinoma of the liver]. 61
23714671 2013
10
Hand-assisted laparoscopic hepatectomy for primary clear cell hepatocellular carcinoma of the liver. 61
22754494 2012
11
A case of primary clear cell hepatocellular carcinoma in a non-cirrhotic liver: an immunohistochemical and ultrastructural study. 61
22826786 2012
12
Clear cell hepatocellular carcinoma arising 25 years after the successful treatment of an infantile hepatoblastoma. 61
21057168 2010
13
Synchronous renal cell carcinoma and clear cell hepatocellular carcinoma mimicking metastatic disease. 61
19608351 2010
14
Case of clear-cell hepatocellular carcinoma that developed in the normal liver of a middle-aged woman. 61
18176975 2008
15
Clear cell hepatocellular carcinoma with spontaneous regression of primary and metastatic lesions. 61
16295790 2005
16
Clear cell and non-clear cell hepatocellular carcinoma: a case report and literature review. 61
15481555 2004
17
Clear cell variant of fibrolamellar carcinoma of the liver. 61
11520281 2001
18
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. 61
11420469 2001
19
Histological, genomic and clinical heterogeneity of clear cell hepatocellular carcinoma. 61
11260303 2001
20
Lipid-rich clear-cell hepatocellular carcinoma arising in non-alcoholic steatohepatitis in a patient with diabetes mellitus. 61
11686402 2001
21
Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. 61
10955454 2000
22
[Clear cell hepatocellular carcinoma: significance of CK 19]. 61
10051922 1998
23
Fine-needle aspiration cytomorphology of clear-cell hepatocellular carcinoma. 61
9316789 1997
24
Clinicopathologic study on clear cell hepatocellular carcinoma. 61
8870006 1996
25
DNA image cytometric analysis of primary clear cell carcinoma of the liver. 61
7979920 1994
26
Clear cell carcinoma of the liver with spontaneous regression of metastases. 61
7967613 1994
27
Clear cell hepatocellular carcinoma treated with liver transplantation. 61
7808805 1994
28
Aspiration cytodiagnosis of clear cell hepatocellular carcinoma in an elderly woman. A case report. 61
7514835 1994
29
[Clear cell hepatocellular carcinoma]. 61
8279278 1993
30
Clear cell hepatocellular carcinoma with abundant myxoid stroma. 61
1337818 1992
31
Cytodiagnosis of clear cell hepatocellular carcinoma. A case report. 61
1659094 1991
32
A clinico-pathologic study of clear-cell hepatocellular carcinoma. 61
2821664 1987
33
Cytopathology of clear-cell hepatocellular carcinoma in ascitic fluid. 61
2996277 1985
34
Clear cell hepatocellular carcinoma: sudden death from severe hypoglycemia. 61
2983534 1985
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Variations for Hepatocellular Clear Cell Carcinoma

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Cosmic variations for Hepatocellular Clear Cell Carcinoma:

9 (show top 50) (show all 15388)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM97724722 ZXDB liver,NS,carcinoma,hepatocellular carcinoma c.1308C>A p.D436E 23:57593356-57593356 3
2 COSM94436083 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
3 COSM94063771 ZSCAN20 liver,NS,carcinoma,hepatocellular carcinoma c.2314G>T p.G772W 1:33494658-33494658 3
4 COSM88264637 ZRSR2 liver,NS,carcinoma,hepatocellular carcinoma c.304G>T p.E102* 23:15803788-15803788 3
5 COSM131494492 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.1159A>G p.M387V 22:29049340-29049340 3
6 COSM102131817 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
7 COSM113317148 ZNF853 liver,NS,carcinoma,hepatocellular carcinoma c.1610G>T p.G537V 7:6622601-6622601 3
8 COSM128686611 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.1072T>A p.F358I 19:36891962-36891962 3
9 COSM123949383 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581= 4:145885684-145885684 3
10 COSM86004822 ZNF653 liver,NS,carcinoma,hepatocellular carcinoma c.1553A>C p.H518P 19:11485673-11485673 3
11 COSM139729931 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
12 COSM91868668 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.3900G>T p.K1300N 19:30557161-30557161 3
13 COSM91880764 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.2171-78T>G p.? 19:30534769-30534769 3
14 COSM94799980 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.3658+205G>A p.? 18:25194955-25194955 3
15 COSM90582798 ZNF518B liver,NS,carcinoma,hepatocellular carcinoma c.1624G>T p.E542* 4:10444705-10444705 3
16 COSM87577038 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.6715G>T p.V2239L 9:106974156-106974156 3
17 COSM151538615 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.253+23785G>T p.? 2:179745718-179745718 3
18 COSM111609487 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1444C>G p.L482V 16:89734008-89734008 3
19 COSM92353291 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.1010C>T p.T337I 12:133010889-133010889 3
20 COSM95253159 ZNF217 liver,NS,carcinoma,hepatocellular carcinoma c.*194A>T p.? 20:53569094-53569094 3
21 COSM94505616 ZMYND12 liver,NS,carcinoma,hepatocellular carcinoma c.425-1G>T p.? 1:42440026-42440026 3
22 COSM89943752 ZMYM4 liver,NS,carcinoma,hepatocellular carcinoma c.86-8201G>T p.? 1:35350724-35350724 3
23 COSM101398456 ZIC2 liver,NS,carcinoma,hepatocellular carcinoma c.-18C>T p.? 13:99982047-99982047 3
24 COSM92703312 ZGPAT liver,NS,carcinoma,hepatocellular carcinoma c.*197C>A p.? 20:63736116-63736116 3
25 COSM92032561 ZFYVE26 liver,NS,carcinoma,hepatocellular carcinoma c.663C>A p.A221= 14:67807621-67807621 3
26 COSM84360265 ZFR liver,NS,carcinoma,hepatocellular carcinoma c.1979+14C>A p.? 5:32395145-32395145 3
27 COSM84362097 ZFR liver,NS,carcinoma,hepatocellular carcinoma c.2882C>T p.P961L 5:32364229-32364229 3
28 COSM85178149 ZFP36L2 liver,NS,carcinoma,hepatocellular carcinoma c.910T>G p.S304A 2:43224894-43224894 3
29 COSM87884183 ZFP28 liver,NS,carcinoma,hepatocellular carcinoma c.1865G>A p.C622Y 19:56554650-56554650 3
30 COSM127392053 ZFHX4 liver,NS,carcinoma,hepatocellular carcinoma c.10601C>G p.S3534C 8:76864315-76864315 3
31 COSM149268658 ZFHX3 liver,NS,carcinoma,hepatocellular carcinoma c.9997C>T p.Q3333* 16:72788279-72788279 3
32 COSM149328017 ZFHX3 liver,NS,carcinoma,hepatocellular carcinoma c.10852C>A p.P3618T 16:72787424-72787424 3
33 COSM149281099 ZFHX3 liver,NS,carcinoma,hepatocellular carcinoma c.8342A>G p.Q2781R 16:72794340-72794340 3
34 COSM144309108 ZEB2 liver,NS,carcinoma,hepatocellular carcinoma c.1141A>G p.M381V 2:144400046-144400046 3
35 COSM87420403 ZCCHC14 liver,NS,carcinoma,hepatocellular carcinoma c.71A>T p.Q24L 16:87491757-87491757 3
36 COSM98996636 ZC3H7A liver,NS,carcinoma,hepatocellular carcinoma c.2866A>G p.N956D 16:11751367-11751367 3
37 COSM92255466 ZC3H15 liver,NS,carcinoma,hepatocellular carcinoma c.*55T>G p.? 2:186508788-186508788 3
38 COSM85044193 ZC3H14 liver,NS,carcinoma,hepatocellular carcinoma c.*10873G>A p.? 14:88622624-88622624 3
39 COSM106743522 ZBTB7B liver,NS,carcinoma,hepatocellular carcinoma c.*635G>C p.? 1:155017320-155017320 3
40 COSM93795261 ZBTB41 liver,NS,carcinoma,hepatocellular carcinoma c.1700G>A p.R567K 1:197178489-197178489 3
41 COSM103188148 ZBTB40 liver,NS,carcinoma,hepatocellular carcinoma c.3339C>A p.F1113L 1:22524258-22524258 3
42 COSM91488114 ZBTB4 liver,NS,carcinoma,hepatocellular carcinoma c.454G>T p.G152C 17:7466348-7466348 3
43 COSM95291738 ZBTB37 liver,NS,carcinoma,hepatocellular carcinoma c.620G>C p.S207T 1:173870845-173870845 3
44 COSM107993551 ZBTB10 liver,NS,carcinoma,hepatocellular carcinoma c.2383A>G p.I795V 8:80519295-80519295 3
45 COSM107993152 ZBTB10 liver,NS,carcinoma,hepatocellular carcinoma c.2208A>G p.T736= 8:80518852-80518852 3
46 COSM86073785 ZBED4 liver,NS,carcinoma,hepatocellular carcinoma c.2225A>C p.E742A 22:49885887-49885887 3
47 COSM142300159 YTHDF3 liver,NS,carcinoma,hepatocellular carcinoma c.1580A>G p.N527S 8:63187582-63187582 3
48 COSM90849676 YOD1 liver,NS,carcinoma,hepatocellular carcinoma c.*157T>C p.? 1:207048863-207048863 3
49 COSM90620829 YME1L1 liver,NS,carcinoma,hepatocellular carcinoma c.2006A>G p.H669R 10:27116230-27116230 3
50 COSM86902201 YEATS2 liver,NS,carcinoma,hepatocellular carcinoma c.501C>T p.N167= 3:183722100-183722100 3
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Expression for Hepatocellular Clear Cell Carcinoma

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Search GEO for disease gene expression data for Hepatocellular Clear Cell Carcinoma.
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Pathways for Hepatocellular Clear Cell Carcinoma

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Pathways related to Hepatocellular Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Sterol Regulatory Element-Binding Proteins (SREBP) signalling 1
10.49 FGF21 AMFR
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GO Terms for Hepatocellular Clear Cell Carcinoma

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Biological processes related to Hepatocellular Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum unfolded protein response GO:0030968 8.62 FGF21 AMFR
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Sources for Hepatocellular Clear Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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