MCID: HPT011
MIFTS: 46

Hepatocellular Clear Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hepatocellular Clear Cell Carcinoma

MalaCards integrated aliases for Hepatocellular Clear Cell Carcinoma:

Name: Hepatocellular Clear Cell Carcinoma 12 15
Hepatocellular Carcinoma, Clear Cell Type 12
Clear Cell Carcinoma of the Liver Cells 12
Clear Cell Hepatocellular Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5016
NCIt 50 C5754
UMLS 70 C1333067

Summaries for Hepatocellular Clear Cell Carcinoma

MalaCards based summary : Hepatocellular Clear Cell Carcinoma, also known as hepatocellular carcinoma, clear cell type, is related to adult teratoma and outlet dysfunction constipation, and has symptoms including fever, abdominal pain and icterus. An important gene associated with Hepatocellular Clear Cell Carcinoma is FGF21 (Fibroblast Growth Factor 21), and among its related pathways/superpathways are Developmental Biology and Class I MHC mediated antigen processing and presentation. Affiliated tissues include liver, bone and lung, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Hepatocellular Clear Cell Carcinoma

Diseases related to Hepatocellular Clear Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 adult teratoma 10.2 FGFR2 AFP
2 outlet dysfunction constipation 10.2 KLB FGFR4 FGF19
3 conjunctival deposit 10.2 KL FGF23
4 tracheal calcification 10.1 KL FGF23
5 extrahepatic cholestasis 10.1 NR1H4 FGFR4 FGF19
6 nephrolithiasis/osteoporosis, hypophosphatemic, 1 10.1 KL FGF23
7 orbit embryonal rhabdomyosarcoma 10.1 FOXO1 FGFR4
8 dental abscess 10.1 KL FGF23
9 parameningeal embryonal rhabdomyosarcoma 10.1 FOXO1 FGFR4
10 lipid storage disease 10.1 NR1H4 MLXIPL FGF21
11 cholangitis, primary sclerosing 10.0 NR1H4 FGF19 AFP
12 hypophosphatemic rickets with hypercalciuria, hereditary 10.0 KL FGF23
13 hypervitaminosis d 10.0 VDR KL FGF23
14 functional diarrhea 10.0 NR1H4 KLB FGFR4 FGF19
15 bile duct disease 10.0 NR1H4 FGF19 AFP
16 rickets 10.0 VDR KL FGF23
17 fgfr craniosynostosis syndromes 10.0 FGFR2 FGFR1
18 parathyroid gland disease 10.0 VDR KL FGF23
19 mineral metabolism disease 10.0 VDR KL FGF23
20 hyperphosphatemia 10.0 VDR KL FGF23
21 secondary hyperparathyroidism 10.0 VDR KL FGF23
22 hyperparathyroidism 10.0 VDR KL FGF23
23 bone remodeling disease 10.0 VDR KL FGF23
24 plagiocephaly 10.0 FGFR2 FGFR1
25 calcinosis 9.9 KL FGFR2 FGF23
26 calciphylaxis 9.9 VDR FGF23
27 syndromic craniosynostosis 9.9 FGFR2 FGFR1
28 hypertelorism, microtia, facial clefting syndrome 9.9 FGFR2 FGFR1
29 fibrolamellar carcinoma 9.9 FGFR2 FGFR1 AFP
30 orbit rhabdomyosarcoma 9.9 FOXO1 FGFR4
31 achondroplasia, severe, with developmental delay and acanthosis nigricans 9.9 FGFR4 FGFR2 FGFR1
32 tumoral calcinosis, hyperphosphatemic, familial, 1 9.9 KL FGFR1 FGF23
33 thanatophoric dysplasia, type i 9.9 FGFR4 FGFR2 FGFR1
34 hypochondroplasia 9.9 FGFR4 FGFR2 FGFR1
35 primary hyperparathyroidism 9.8 VDR KL FGF23
36 crouzon syndrome 9.8 FGFR4 FGFR2 FGFR1
37 familial tumoral calcinosis 9.8 KL FGF23
38 hypophosphatemic rickets, x-linked dominant 9.7 KL FGFR4 FGFR1 FGF23
39 leber plus disease 9.7 VDR NR1H4 KLB FGFR4 FGF19 AFP
40 phosphorus metabolism disease 9.7 VDR KL FGFR1 FGF23
41 hypophosphatemia 9.7 VDR KL FGFR1 FGF23
42 lacrimoauriculodentodigital syndrome 9.7 FGFR4 FGFR2 FGFR1 FGF23
43 nevus, epidermal 9.7 FGFR4 FGFR2 FGFR1 FGF23
44 osteoglophonic dysplasia 9.6 KL FGFR2 FGFR1 FGF23
45 osteochondrodysplasia 9.6 FGFR4 FGFR2 FGFR1 FGF23
46 lung squamous cell carcinoma 9.5 STK11 FGFR4 FGFR2 FGFR1
47 bone disease 9.5 VDR FGFR2 FGFR1 FGF23
48 diabetes mellitus 9.4 VDR KL FOXO1 FGF23 FGF21 FGF19
49 type 2 diabetes mellitus 9.1 VDR SDHB NR1H4 KL FOXO1 FGF23

Graphical network of the top 20 diseases related to Hepatocellular Clear Cell Carcinoma:



Diseases related to Hepatocellular Clear Cell Carcinoma

Symptoms & Phenotypes for Hepatocellular Clear Cell Carcinoma

UMLS symptoms related to Hepatocellular Clear Cell Carcinoma:


fever; abdominal pain; icterus; malaise

MGI Mouse Phenotypes related to Hepatocellular Clear Cell Carcinoma:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.49 AMFR FGF19 FGF21 FGF23 FGFR1 FGFR2
2 homeostasis/metabolism MP:0005376 10.48 AFP AMFR FGF21 FGF23 FGFR1 FGFR2
3 behavior/neurological MP:0005386 10.45 AFP FGF21 FGFR1 FGFR2 FOXO1 KL
4 mortality/aging MP:0010768 10.39 AFP AMFR FGF19 FGF23 FGFR1 FGFR2
5 endocrine/exocrine gland MP:0005379 10.38 AFP FGF23 FGFR1 FGFR2 FOXO1 KL
6 cellular MP:0005384 10.37 AMFR FGF19 FGFR1 FGFR2 FGFR4 FOXO1
7 cardiovascular system MP:0005385 10.34 FGF19 FGF23 FGFR1 FGFR2 FOXO1 KL
8 immune system MP:0005387 10.32 AMFR FGF23 FGFR1 FGFR2 FGFR4 FOXO1
9 hematopoietic system MP:0005397 10.31 FGF23 FGFR1 FGFR2 FGFR4 FOXO1 KL
10 digestive/alimentary MP:0005381 10.27 FGF23 FGFR1 FGFR2 FOXO1 KL MLXIPL
11 integument MP:0010771 10.24 FGF19 FGF23 FGFR1 FGFR2 FOXO1 KL
12 liver/biliary system MP:0005370 10.2 AFP AMFR FGF21 FGFR2 FOXO1 KL
13 adipose tissue MP:0005375 10.16 FGF21 FGFR2 FOXO1 KL KLB MLXIPL
14 craniofacial MP:0005382 10.13 FGFR1 FGFR2 FOXO1 KL LOX STK11
15 limbs/digits/tail MP:0005371 10.13 FGF21 FGF23 FGFR1 FGFR2 FOXO1 KL
16 neoplasm MP:0002006 10.07 AFP AMFR FGFR2 FGFR4 FOXO1 LOX
17 hearing/vestibular/ear MP:0005377 10.02 FGF19 FGFR1 FGFR2 FGFR4 KL VDR
18 muscle MP:0005369 10.01 FGFR1 FGFR2 FOXO1 KL LOX STK11
19 no phenotypic analysis MP:0003012 9.92 FGF21 FGFR1 FGFR2 FOXO1 KLB NR1H4
20 renal/urinary system MP:0005367 9.86 FGF23 FGFR1 FGFR2 KL SDHB STK11
21 reproductive system MP:0005389 9.85 AFP FGF23 FGFR1 FGFR2 FGFR4 FOXO1
22 respiratory system MP:0005388 9.5 FGF23 FGFR2 FGFR4 KL LOX SAV1
23 skeleton MP:0005390 9.36 FGF21 FGF23 FGFR1 FGFR2 FGFR4 FOXO1

Drugs & Therapeutics for Hepatocellular Clear Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Hepatocellular Clear Cell Carcinoma

Genetic Tests for Hepatocellular Clear Cell Carcinoma

Anatomical Context for Hepatocellular Clear Cell Carcinoma

MalaCards organs/tissues related to Hepatocellular Clear Cell Carcinoma:

40
Liver, Bone, Lung

Publications for Hepatocellular Clear Cell Carcinoma

Articles related to Hepatocellular Clear Cell Carcinoma:

(show all 35)
# Title Authors PMID Year
1
New Names for Old Tumors. 61
33258899 2020
2
A case of primary clear cell hepatocellular carcinoma comprised mostly of clear cells. 61
31695824 2019
3
Unusual isolated pelvic metastasis from a clear cell hepatocellular carcinoma demonstrated on 18F-FDG PET/CT after liver transplantation. 61
28434874 2018
4
Clear cell hepatocellular carcinoma: origin, metabolic traits and fate of glycogenotic clear and ground glass cells. 61
29291777 2017
5
Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma. 61
28460432 2017
6
IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing. 61
28403884 2017
7
Clear cell hepatocellular carcinoma diagnosed by bile duct brushing cytology. 61
26638110 2016
8
Clear cell hepatocellular carcinoma: Back to the basics for diagnosis. 61
26458650 2015
9
[Expression of carbonic anhydrase IX, PAX2 and PAX8 and their association with clinicopathologic characteristics in renal epithelial tumors]. 61
24246861 2013
10
[Clinicopathological and prognostic analysis of primary clear cell carcinoma of the liver]. 61
23714671 2013
11
Hand-assisted laparoscopic hepatectomy for primary clear cell hepatocellular carcinoma of the liver. 61
22754494 2012
12
A case of primary clear cell hepatocellular carcinoma in a non-cirrhotic liver: an immunohistochemical and ultrastructural study. 61
22826786 2012
13
Clear cell hepatocellular carcinoma arising 25 years after the successful treatment of an infantile hepatoblastoma. 61
21057168 2010
14
Synchronous renal cell carcinoma and clear cell hepatocellular carcinoma mimicking metastatic disease. 61
19608351 2010
15
Case of clear-cell hepatocellular carcinoma that developed in the normal liver of a middle-aged woman. 61
18176975 2008
16
Clear cell hepatocellular carcinoma with spontaneous regression of primary and metastatic lesions. 61
16295790 2005
17
Clear cell and non-clear cell hepatocellular carcinoma: a case report and literature review. 61
15481555 2004
18
Clear cell variant of fibrolamellar carcinoma of the liver. 61
11520281 2001
19
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. 61
11420469 2001
20
Histological, genomic and clinical heterogeneity of clear cell hepatocellular carcinoma. 61
11260303 2001
21
Lipid-rich clear-cell hepatocellular carcinoma arising in non-alcoholic steatohepatitis in a patient with diabetes mellitus. 61
11686402 2001
22
Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. 61
10955454 2000
23
[Clear cell hepatocellular carcinoma: significance of CK 19]. 61
10051922 1998
24
Fine-needle aspiration cytomorphology of clear-cell hepatocellular carcinoma. 61
9316789 1997
25
Clinicopathologic study on clear cell hepatocellular carcinoma. 61
8870006 1996
26
DNA image cytometric analysis of primary clear cell carcinoma of the liver. 61
7979920 1994
27
Clear cell carcinoma of the liver with spontaneous regression of metastases. 61
7967613 1994
28
Clear cell hepatocellular carcinoma treated with liver transplantation. 61
7808805 1994
29
Aspiration cytodiagnosis of clear cell hepatocellular carcinoma in an elderly woman. A case report. 61
7514835 1994
30
[Clear cell hepatocellular carcinoma]. 61
8279278 1993
31
Clear cell hepatocellular carcinoma with abundant myxoid stroma. 61
1337818 1992
32
Cytodiagnosis of clear cell hepatocellular carcinoma. A case report. 61
1659094 1991
33
A clinico-pathologic study of clear-cell hepatocellular carcinoma. 61
2821664 1987
34
Cytopathology of clear-cell hepatocellular carcinoma in ascitic fluid. 61
2996277 1985
35
Clear cell hepatocellular carcinoma: sudden death from severe hypoglycemia. 61
2983534 1985

Variations for Hepatocellular Clear Cell Carcinoma

Cosmic variations for Hepatocellular Clear Cell Carcinoma:

9 (show top 50) (show all 15388)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM97724722 ZXDB liver,NS,carcinoma,hepatocellular carcinoma c.1308C>A p.D436E 23:57593356-57593356 3
2 COSM94430614 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
3 COSM94436083 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
4 COSM94063771 ZSCAN20 liver,NS,carcinoma,hepatocellular carcinoma c.2314G>T p.G772W 1:33494658-33494658 3
5 COSM88264637 ZRSR2 liver,NS,carcinoma,hepatocellular carcinoma c.304G>T p.E102* 23:15803788-15803788 3
6 COSM102741209 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.859A>G p.M287V 22:29049340-29049340 3
7 COSM131494492 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.1159A>G p.M387V 22:29049340-29049340 3
8 COSM103081572 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.859A>G p.M287V 22:29049340-29049340 3
9 COSM95977701 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
10 COSM102131817 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
11 COSM95960776 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
12 COSM113317148 ZNF853 liver,NS,carcinoma,hepatocellular carcinoma c.1610G>T p.G537V 7:6622601-6622601 3
13 COSM99592496 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.829T>A p.F277I 19:36891962-36891962 3
14 COSM128686611 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.1072T>A p.F358I 19:36891962-36891962 3
15 COSM123358576 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.691C>T p.L231= 4:145885684-145885684 3
16 COSM123949383 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581= 4:145885684-145885684 3
17 COSM101741672 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581= 4:145885684-145885684 3
18 COSM86004822 ZNF653 liver,NS,carcinoma,hepatocellular carcinoma c.1553A>C p.H518P 19:11485673-11485673 3
19 COSM98561269 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
20 COSM142353152 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
21 COSM142221290 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
22 COSM99854658 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.156G>A p.V52= 19:52002156-52002156 3
23 COSM139729931 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
24 COSM141470046 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
25 COSM141819438 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
26 COSM145038099 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
27 COSM91868668 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.3900G>T p.K1300N 19:30557161-30557161 3
28 COSM91880764 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.2171-78T>G p.? 19:30534769-30534769 3
29 COSM140721836 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.2998+205G>A p.? 18:25194955-25194955 3
30 COSM131506983 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.3658+205G>A p.? 18:25194955-25194955 3
31 COSM94799980 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.3658+205G>A p.? 18:25194955-25194955 3
32 COSM90582798 ZNF518B liver,NS,carcinoma,hepatocellular carcinoma c.1624G>T p.E542* 4:10444705-10444705 3
33 COSM87577038 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.6715G>T p.V2239L 9:106974156-106974156 3
34 COSM109096265 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.3433G>T p.V1145L 9:106974156-106974156 3
35 COSM104985080 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.298+23785G>T p.? 2:179745718-179745718 3
36 COSM104427909 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.20G>T p.S7I 2:179745718-179745718 3
37 COSM151538615 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.253+23785G>T p.? 2:179745718-179745718 3
38 COSM127708351 ZNF345 liver,NS,carcinoma,hepatocellular carcinoma c.47-856A>T p.? 19:36891962-36891962 3
39 COSM135887725 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1168C>G p.L390V 16:89734008-89734008 3
40 COSM84511025 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1219C>G p.L407V 16:89734008-89734008 3
41 COSM111609487 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1444C>G p.L482V 16:89734008-89734008 3
42 COSM92353291 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.1010C>T p.T337I 12:133010889-133010889 3
43 COSM130415812 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.950C>T p.T317I 12:133010889-133010889 3
44 COSM88697750 ZNF217 liver,NS,carcinoma,hepatocellular carcinoma c.*194A>T p.? 20:53569094-53569094 3
45 COSM95253159 ZNF217 liver,NS,carcinoma,hepatocellular carcinoma c.*194A>T p.? 20:53569094-53569094 3
46 COSM94505616 ZMYND12 liver,NS,carcinoma,hepatocellular carcinoma c.425-1G>T p.? 1:42440026-42440026 3
47 COSM89943752 ZMYM4 liver,NS,carcinoma,hepatocellular carcinoma c.86-8201G>T p.? 1:35350724-35350724 3
48 COSM101398456 ZIC2 liver,NS,carcinoma,hepatocellular carcinoma c.-18C>T p.? 13:99982047-99982047 3
49 COSM113521587 ZGPAT liver,NS,carcinoma,hepatocellular carcinoma c.*197C>A p.? 20:63736116-63736116 3
50 COSM94679661 ZGPAT liver,NS,carcinoma,hepatocellular carcinoma c.*197C>A p.? 20:63736116-63736116 3

Expression for Hepatocellular Clear Cell Carcinoma

Search GEO for disease gene expression data for Hepatocellular Clear Cell Carcinoma.

Pathways for Hepatocellular Clear Cell Carcinoma

Pathways related to Hepatocellular Clear Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 KLB KL FOXO1 FGFR4 FGFR2 FGFR1
2
Show member pathways
13.4 STUB1 KLB KL FOXO1 FGFR4 FGFR2
3
Show member pathways
13.35 FOXO1 FGFR4 FGFR2 FGFR1 FGF23 FGF21
4
Show member pathways
13.33 KLB KL FOXO1 FGFR4 FGFR2 FGFR1
5
Show member pathways
13.24 STUB1 FGFR4 FGFR2 FGFR1 FGF23 FGF21
6
Show member pathways
13.04 KLB KL FOXO1 FGFR4 FGFR2 FGFR1
7
Show member pathways
13.02 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
8
Show member pathways
13.02 STK11 FGFR4 FGFR2 FGFR1 FGF23 FGF21
9
Show member pathways
12.84 STK11 FOXO1 FGFR4 FGFR2 FGFR1 FGF23
10
Show member pathways
12.77 KLB KL FGFR4 FGFR2 FGFR1 FGF23
11 12.75 FOXO1 FGFR4 FGFR2 FGFR1 FGF23 FGF21
12 12.74 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
13
Show member pathways
12.72 FGFR2 FGFR1 FGF23 FGF21 FGF19
14
Show member pathways
12.71 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
15
Show member pathways
12.67 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
16
Show member pathways
12.64 FOXO1 FGFR2 FGFR1 FGF23 FGF21 FGF19
17 12.59 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
18
Show member pathways
12.5 KLB KL FOXO1 FGFR4 FGFR2 FGFR1
19
Show member pathways
12.44 STK11 FGFR4 FGFR2 FGFR1
20
Show member pathways
12.39 KLB KL FGFR4 FGFR2 FGFR1 FGF23
21
Show member pathways
12.38 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
22
Show member pathways
12.31 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
23 12.29 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
24
Show member pathways
12.26 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
25
Show member pathways
12.22 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
26
Show member pathways
12.16 FOXO1 FGFR4 FGFR2 FGFR1
27
Show member pathways
12.13 FGFR4 FGFR2 FGFR1 FGF23
28
Show member pathways
11.99 KLB KL FGFR4 FGFR2 FGFR1 FGF23
29
Show member pathways
11.96 STK11 KLB KL FGFR4 FGFR2 FGFR1
30 11.94 VDR KL FGFR1 FGF23
31 11.86 FGFR2 FGFR1 FGF19
32 11.79 FGFR4 FGFR2 FGFR1
33 11.69 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
34 11.47 FGFR4 FGFR2 FGFR1
35 11.44 FGFR4 FGFR2 FGFR1
36 11 FGFR4 FGFR2 FGFR1 FGF23 FGF21 FGF19
37 10.96 NR1H4 FGF19
38 10.91 VDR NR1H4
39 10.81 VDR NR1H4
40 10.77 KLB FGFR4 FGFR2 FGFR1 FGF23 FGF19

GO Terms for Hepatocellular Clear Cell Carcinoma

Cellular components related to Hepatocellular Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 LOX KL FGFR4 FGFR2 FGFR1 FGF23
2 cytoplasm GO:0005737 9.8 VDR STUB1 STK11 SAV1 MLXIPL FOXO1
3 receptor complex GO:0043235 9.02 VDR NR1H4 FGFR4 FGFR2 FGFR1

Biological processes related to Hepatocellular Clear Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.04 VDR STK11 NR1H4 FOXO1 FGF23 FGF21
2 positive regulation of gene expression GO:0010628 9.97 VDR FGFR4 FGF23 FGF21 FGF19
3 positive regulation of cell proliferation GO:0008284 9.92 MLXIPL KLB FGFR4 FGFR2 FGFR1 FGF23
4 protein autophosphorylation GO:0046777 9.84 STK11 FGFR4 FGFR2 FGFR1
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.8 FGFR4 FGFR2 FGFR1
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 FGFR4 FGFR2 FGF23 FGF21 FGF19
7 MAPK cascade GO:0000165 9.8 KLB KL FGFR4 FGFR2 FGFR1 FGF23
8 regulation of cell migration GO:0030334 9.77 FGF23 FGF21 FGF19
9 animal organ morphogenesis GO:0009887 9.77 VDR FGFR2 FGF23 FGF21 FGF19
10 positive regulation of kinase activity GO:0033674 9.74 FGFR4 FGFR2 FGFR1
11 glucose homeostasis GO:0042593 9.73 STK11 NR1H4 MLXIPL FGFR4
12 endoplasmic reticulum unfolded protein response GO:0030968 9.7 STUB1 FGF21 AMFR
13 positive regulation of protein kinase B signaling GO:0051897 9.7 KLB KL FGFR4 FGFR2 FGFR1 FGF23
14 positive regulation of proteolysis GO:0045862 9.62 STUB1 FGFR4
15 fatty acid homeostasis GO:0055089 9.61 NR1H4 MLXIPL
16 negative regulation of keratinocyte proliferation GO:0010839 9.61 VDR FGFR2
17 vitamin D metabolic process GO:0042359 9.59 VDR FGF23
18 bile acid signaling pathway GO:0038183 9.58 VDR NR1H4
19 positive regulation of phospholipase activity GO:0010518 9.56 FGFR2 FGFR1
20 phosphate ion homeostasis GO:0055062 9.55 FGFR4 FGF23
21 regulation of bile acid biosynthetic process GO:0070857 9.51 NR1H4 FGFR4
22 regulation of low-density lipoprotein particle clearance GO:0010988 9.48 NR1H4 FGF21
23 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.46 VDR FGF23
24 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.26 KLB KL FGF23 FGF21
25 fibroblast growth factor receptor signaling pathway GO:0008543 9.23 KLB KL FGFR4 FGFR2 FGFR1 FGF23

Molecular functions related to Hepatocellular Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.58 FGFR4 FGFR2 FGFR1
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 FGFR4 FGFR2 FGFR1
3 retinoid X receptor binding GO:0046965 9.37 VDR NR1H4
4 fibroblast growth factor receptor binding GO:0005104 9.35 KLB KL FGF23 FGF21 FGF19
5 fibroblast growth factor-activated receptor activity GO:0005007 9.33 FGFR4 FGFR2 FGFR1
6 ubiquitin-ubiquitin ligase activity GO:0034450 9.32 STUB1 AMFR
7 fibroblast growth factor binding GO:0017134 9.02 KLB KL FGFR4 FGFR2 FGFR1

Sources for Hepatocellular Clear Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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