MCID: HPT079
MIFTS: 30

Hepatoid Adenocarcinoma

Categories: Cancer diseases, Liver diseases

Aliases & Classifications for Hepatoid Adenocarcinoma

MalaCards integrated aliases for Hepatoid Adenocarcinoma:

Name: Hepatoid Adenocarcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060534
NCIt 50 C66950
UMLS 73 C1266090

Summaries for Hepatoid Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver.

MalaCards based summary : Hepatoid Adenocarcinoma is related to horseshoe kidney and gastric adenocarcinoma. An important gene associated with Hepatoid Adenocarcinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include liver, lung and cervix, and related phenotypes are Reduced mammosphere formation and liver/biliary system

Related Diseases for Hepatoid Adenocarcinoma

Diseases related to Hepatoid Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 horseshoe kidney 29.5 CDX2 EGFR
2 gastric adenocarcinoma 29.0 AFP CDX2 EGFR
3 tubular adenocarcinoma 28.5 AFP CDX2 EGFR MUC1
4 bladder hepatoid adenocarcinoma 12.1
5 adenocarcinoma 10.8
6 bile duct cystadenocarcinoma 10.4 AFP MUC1
7 sertoli-leydig cell tumor 10.4 AFP MUC1
8 cystadenofibroma 10.4 AFP MUC1
9 bile duct adenocarcinoma 10.3 AFP MUC1
10 esophageal varix 10.3 AFP ALB
11 endodermal sinus tumor 10.3 AFP ALB
12 rh isoimmunization 10.2 AFP ALB
13 mucinous bronchioloalveolar adenocarcinoma 10.2 CDX2 MUC1
14 mucinous ovarian cystadenoma 10.2 CDX2 MUC1
15 villous adenoma 10.2 CDX2 MUC1
16 ampulla of vater neoplasm 10.2 CDX2 MUC1
17 appendix cancer 10.2 CDX2 MUC1
18 ampulla of vater adenocarcinoma 10.2 CDX2 MUC1
19 biliary papillomatosis 10.2 CDX2 MUC1
20 hepatic vascular disease 10.2 AFP ALB
21 biliary tract neoplasm 10.2 CDX2 MUC1
22 duodenum cancer 10.2 CDX2 MUC1
23 vein disease 10.2 AFP ALB
24 pseudomyxoma peritonei 10.1 CDX2 MUC1
25 hepatitis a 10.1 AFP ALB
26 gastric tubular adenocarcinoma 10.1 CDX2 MUC1
27 hepatocellular carcinoma 10.1
28 signet ring cell adenocarcinoma 10.1 CDX2 MUC1
29 secretory meningioma 10.1 CDX2 MUC1
30 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 ALB CDX2
31 hepatitis 10.1
32 pneumocystosis 10.1 ALB MUC1
33 teratoma 10.1 AFP CDX2
34 alcoholic liver cirrhosis 10.0 AFP ALB
35 gastric cancer 10.0
36 choriocarcinoma 10.0
37 mediastinitis 10.0
38 cholecystitis 9.9 ALB MUC1
39 breast scirrhous carcinoma 9.9 EGFR MUC1
40 malignant peritoneal mesothelioma 9.9 EGFR MUC1
41 bronchiolo-alveolar adenocarcinoma 9.9 CDX2 EGFR
42 lung cancer 9.8
43 barrett esophagus 9.8
44 small cell carcinoma 9.8
45 large cell neuroendocrine carcinoma 9.8
46 tonsillitis 9.8
47 azoospermia 9.8
48 extrahepatic bile duct adenocarcinoma 9.8
49 pancreatitis 9.8
50 peritonitis 9.8

Graphical network of the top 20 diseases related to Hepatoid Adenocarcinoma:



Diseases related to Hepatoid Adenocarcinoma

Symptoms & Phenotypes for Hepatoid Adenocarcinoma

GenomeRNAi Phenotypes related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 AFP ALB EGFR HNF4A

MGI Mouse Phenotypes related to Hepatoid Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.26 AFP ALB EGFR HNF4A
2 neoplasm MP:0002006 8.92 AFP ALB CDX2 EGFR

Drugs & Therapeutics for Hepatoid Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Hepatoid Adenocarcinoma

Genetic Tests for Hepatoid Adenocarcinoma

Anatomical Context for Hepatoid Adenocarcinoma

MalaCards organs/tissues related to Hepatoid Adenocarcinoma:

41
Liver, Lung, Cervix, Tonsil, Pancreas, Colon, Lymph Node

Publications for Hepatoid Adenocarcinoma

Articles related to Hepatoid Adenocarcinoma:

(show top 50) (show all 75)
# Title Authors Year
1
Cytological features of hepatoid adenocarcinoma of the gallbladder: A case report with immunocytochemical analyzes. ( 29637715 )
2018
2
A Mismatch Repair-Deficient Hepatoid Adenocarcinoma of the Lung Responding to Anti-PD-L1 Durvalumab Therapy Despite no PD-L1 Expression. ( 29935850 )
2018
3
Chemotherapy of metastatic hepatoid adenocarcinoma: Literature review and two case reports with cisplatin etoposide. ( 29387209 )
2018
4
HER2 is frequently overexpressed in hepatoid adenocarcinoma and gastric carcinoma with enteroblastic differentiation: a comparison of 35 cases to 334 gastric carcinomas of other histological types. ( 29305518 )
2018
5
Clinicopathological features and prognosis of intestinal hepatoid adenocarcinoma: evaluation of a pooled case series. ( 29416804 )
2018
6
Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma. ( 29751042 )
2018
7
Hepatoid Adenocarcinoma of Unknown Primary Masquerading as a Pancreatic Tumor. ( 28681213 )
2017
8
Hepatoid Adenocarcinoma of the Extrahepatic Bile Duct in a Patient with Polysplenia Syndrome. ( 28202861 )
2017
9
Primary hepatoid adenocarcinoma of the orbit. ( 29503944 )
2017
10
Hepatoid adenocarcinoma of the lung metastasizing to the tonsil. ( 28529745 )
2017
11
Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature. ( 28545511 )
2017
12
Hepatoid Adenocarcinoma of the Stomach: A Challenging Diagnostic and Therapeutic Disease through a Case Report and Review of the Literature. ( 29034239 )
2017
13
CT features of hepatic metastases from hepatoid adenocarcinoma. ( 28421242 )
2017
14
Hepatoid adenocarcinoma of the lung: Review of a rare form of lung cancer. ( 27692141 )
2016
15
18F-FDG PET/CT of Primary Mediastinal Hepatoid Adenocarcinoma. ( 26914554 )
2016
16
Hepatoid Adenocarcinoma of the Urachus. ( 27803830 )
2016
17
Case Report of an Hepatoid Adenocarcinoma of the Stomach. ( 26844385 )
2016
18
Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report. ( 27537551 )
2016
19
Arginase-1 is frequently positive in hepatoid adenocarcinomas. ( 27137985 )
2016
20
Hepatoid adenocarcinoma of the lung. ( 27433025 )
2016
21
Hepatoid adenocarcinoma of the stomach - proper identification and treatment remain a challenge. ( 26728165 )
2016
22
Hepatoid Adenocarcinoma of the Duodenum: An Unusual Location. ( 27064217 )
2016
23
PRISMA-Compliant Article: Clinical Characteristics and Factors Influencing Prognosis of Patients With Hepatoid Adenocarcinoma of the Stomach in China. ( 27082614 )
2016
24
A rare hepatoid adenocarcinoma from the gastric remnant. ( 27638409 )
2016
25
Hepatic metastases from gastric hepatoid adenocarcinoma: An unusual cause of capsular retraction of the liver. ( 27344538 )
2016
26
FDG PET/CT in Hepatoid Adenocarcinoma of the Lung. ( 27124679 )
2016
27
Hepatoid adenocarcinoma of the stomach: A case report of a rare type of gastric cancer. ( 26893695 )
2016
28
Hepatoid adenocarcinoma of the lung without production of I+-fetoprotein: A case report and review of the literature. ( 27347123 )
2016
29
Pulmonary hepatoid adenocarcinoma: report of a case. ( 26943677 )
2016
30
Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma. ( 26094198 )
2015
31
Rare coexistence of mediastinal hepatoid adenocarcinoma, idiopathic azoospermia and horseshoe kidney: a case report and review of the literature. ( 26617920 )
2015
32
Hepatoid adenocarcinoma of the stomach: Nine case reports and treatment outcomes. ( 26622718 )
2015
33
Clinicopathological features of gastric hepatoid adenocarcinoma. ( 26365881 )
2015
34
Hepatoid adenocarcinoma of the stomach: A case report and review of the literature. ( 26137025 )
2015
35
Hepatoid adenocarcinoma of the stomach: A case report and literature review. ( 26136947 )
2015
36
Atypical Presentation of Hepatocellular Carcinoma Mimicking a Gastric Hepatoid Adenocarcinoma: A Case Report. ( 26166099 )
2015
37
Hepatoid Adenocarcinoma of the Gall Bladder-A Rare Variant. ( 26435955 )
2015
38
Ex vivo hepatectomy and partial liver autotransplantation for hepatoid adenocarcinoma: A case report. ( 26137040 )
2015
39
Hepatoid adenocarcinoma of the colon. ( 25883249 )
2015
40
Liver metastasis from hepatoid adenocarcinoma of the stomach mimicking hepatocellular carcinoma: Dynamic computed tomography findings. ( 26730164 )
2015
41
Hepatoid adenocarcinoma of the stomach is a special and easily misdiagnosed or missed diagnosed subtype of gastric cancer with poor prognosis but curative for patients of pN0/1: the experience of a single center. ( 26221214 )
2015
42
Hepatoid Adenocarcinoma of the Lung: A Case Report and Review of the Literature. ( 24408270 )
2014
43
Triple composite tumor of stomach: a rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma. ( 24739843 )
2014
44
A Hepatoid Adenocarcinoma of the Stomach Evaluated With 18F-FDG PET/CT: Intense 18F-FDG Uptake Contrary to the Previous Report. ( 24152637 )
2013
45
Primary hepatoid adenocarcinoma of the uterine corpus: A case report with immunohistochemical study for expression of liver-enriched nuclear factors. ( 21493011 )
2011
46
Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus. ( 20952273 )
2011
47
Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity. ( 20502062 )
2010
48
[A case of liver metastasis of gastric hepatoid adenocarcinoma]. ( 19581772 )
2009
49
AFP-producing hepatoid adenocarcinoma of the stomach: a case report. ( 20062620 )
2009
50
Hepatoid adenocarcinoma of the stomach - a different histology for not so different gastric adenocarcinoma: a case report. ( 19674468 )
2009

Variations for Hepatoid Adenocarcinoma

Cosmic variations for Hepatoid Adenocarcinoma:

9
(show top 50) (show all 3321)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1626018 ZXDB liver,NS,carcinoma,hepatocellular carcinoma c.1308C>A p.D436E 23:57593356-57593356 3
2 COSM1615665 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
3 COSM1602238 ZSCAN20 liver,NS,carcinoma,hepatocellular carcinoma c.2314G>T p.G772W 1:33494658-33494658 3
4 COSM6951673 ZRSR2 liver,NS,carcinoma,hepatocellular carcinoma c.304G>T p.E102* 23:15803788-15803788 3
5 COSM1616325 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.859A>G p.M287V 22:29049340-29049340 3
6 COSM3707828 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860L 20:49257501-49257501 3
7 COSM3707827 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860L 20:49257501-49257501 3
8 COSM1623051 ZNF853 liver,NS,carcinoma,hepatocellular carcinoma c.1610G>T p.G537V 7:6622601-6622601 3
9 COSM1612127 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.829T>A p.F277I 19:36891962-36891962 3
10 COSM1618451 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581L 4:145885684-145885684 3
11 COSM1611545 ZNF653 liver,NS,carcinoma,hepatocellular carcinoma c.1553A>C p.H518P 19:11485673-11485673 3
12 COSM1612685 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47V 19:52002156-52002156 3
13 COSM1612018 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.3900G>T p.K1300N 19:30557161-30557161 3
14 COSM1618219 ZNF518B liver,NS,carcinoma,hepatocellular carcinoma c.1624G>T p.E542* 4:10444705-10444705 3
15 COSM1624399 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.6715G>T p.V2239L 9:106974156-106974156 3
16 COSM1609798 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1219C>G p.L407V 16:89734008-89734008 3
17 COSM1605856 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.1010C>T p.T337I 12:133010889-133010889 3
18 COSM1602404 ZMYND12 liver,NS,carcinoma,hepatocellular carcinoma c.425-1G>T p.? 1:42440026-42440026 3
19 COSM1607880 ZFYVE26 liver,NS,carcinoma,hepatocellular carcinoma c.663C>A p.A221A 14:67807621-67807621 3
20 COSM3661787 ZFR liver,NS,carcinoma,hepatocellular carcinoma c.2882C>T p.P961L 5:32364229-32364229 3
21 COSM1270878 ZFP36L2 liver,NS,carcinoma,hepatocellular carcinoma c.910T>G p.S304A 2:43224894-43224894 3
22 COSM1612900 ZFP28 liver,NS,carcinoma,hepatocellular carcinoma c.1865G>A p.C622Y 19:56554650-56554650 3
23 COSM3663890 ZFHX4 liver,NS,carcinoma,hepatocellular carcinoma c.10601C>G p.S3534C 8:76864315-76864315 3
24 COSM6969923 ZFHX3 liver,NS,carcinoma,hepatocellular carcinoma c.10852C>A p.P3618T 16:72787424-72787424 3
25 COSM3717069 ZFHX3 liver,NS,carcinoma,hepatocellular carcinoma c.8342A>G p.Q2781R 16:72794340-72794340 3
26 COSM6219678 ZFHX3 liver,NS,carcinoma,hepatocellular carcinoma c.9997C>T p.Q3333* 16:72788279-72788279 3
27 COSM1613453 ZEB2 liver,NS,carcinoma,hepatocellular carcinoma c.1141A>G p.M381V 2:144400046-144400046 3
28 COSM3717124 ZCCHC14 liver,NS,carcinoma,hepatocellular carcinoma c.71A>T p.Q24L 16:87491757-87491757 3
29 COSM1608898 ZC3H7A liver,NS,carcinoma,hepatocellular carcinoma c.2866A>G p.N956D 16:11751367-11751367 3
30 COSM3705381 ZBTB41 liver,NS,carcinoma,hepatocellular carcinoma c.1700G>A p.R567K 1:197178489-197178489 3
31 COSM1601838 ZBTB40 liver,NS,carcinoma,hepatocellular carcinoma c.3339C>A p.F1113L 1:22524258-22524258 3
32 COSM1610770 ZBTB4 liver,NS,carcinoma,hepatocellular carcinoma c.454G>T p.G152C 17:7466348-7466348 3
33 COSM1601260 ZBTB37 liver,NS,carcinoma,hepatocellular carcinoma c.620G>C p.S207T 1:173870845-173870845 3
34 COSM1624206 ZBTB10 liver,NS,carcinoma,hepatocellular carcinoma c.2136A>G p.T712T 8:80518852-80518852 3
35 COSM1624207 ZBTB10 liver,NS,carcinoma,hepatocellular carcinoma c.2311A>G p.I771V 8:80519295-80519295 3
36 COSM1616586 ZBED4 liver,NS,carcinoma,hepatocellular carcinoma c.2225A>C p.E742A 22:49885887-49885887 3
37 COSM1624117 YTHDF3 liver,NS,carcinoma,hepatocellular carcinoma c.1568A>G p.N523S 8:63187582-63187582 3
38 COSM1603361 YME1L1 liver,NS,carcinoma,hepatocellular carcinoma c.2006A>G p.H669R 10:27116230-27116230 3
39 COSM1617254 YEATS2 liver,NS,carcinoma,hepatocellular carcinoma c.501C>T p.N167N 3:183722100-183722100 3
40 COSM3663693 XPO7 liver,NS,carcinoma,hepatocellular carcinoma c.806A>G p.Y269C 8:21977812-21977812 3
41 COSM1609152 XPO6 liver,NS,carcinoma,hepatocellular carcinoma c.882C>T p.G294G 16:28156289-28156289 3
42 COSM6957749 XPO1 liver,NS,carcinoma,hepatocellular carcinoma c.301+1G>C p.? 2:61522610-61522610 3
43 COSM1624082 XKR4 liver,NS,carcinoma,hepatocellular carcinoma c.1076A>G p.D359G 8:55523350-55523350 3
44 COSM1613650 XIRP2 liver,NS,carcinoma,hepatocellular carcinoma c.9350G>C p.R3117P 2:167250742-167250742 3
45 COSM3660541 XIRP1 liver,NS,carcinoma,hepatocellular carcinoma c.142C>A p.Q48K 3:39189304-39189304 3
46 COSM1625463 XIAP liver,NS,carcinoma,hepatocellular carcinoma c.493G>T p.A165S 23:123886155-123886155 3
47 COSM3663909 WWP1 liver,NS,carcinoma,hepatocellular carcinoma c.210-2A>G p.? 8:86381503-86381503 3
48 COSM1625309 WWC3 liver,NS,carcinoma,hepatocellular carcinoma c.1121C>A p.S374Y 23:10117180-10117180 3
49 COSM1621161 WTAP liver,NS,carcinoma,hepatocellular carcinoma c.283C>T p.Q95* 6:159748200-159748200 3
50 COSM6909096 WT1 liver,NS,carcinoma,hepatocellular carcinoma c.1019T>G p.L340* 11:32396283-32396283 3

Expression for Hepatoid Adenocarcinoma

Search GEO for disease gene expression data for Hepatoid Adenocarcinoma.

Pathways for Hepatoid Adenocarcinoma

Pathways related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 AFP ALB CDX2
2 10.44 AFP ALB HNF4A

GO Terms for Hepatoid Adenocarcinoma

Cellular components related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 AFP ALB BPIFA1 EGFR MUC1
2 extracellular space GO:0005615 9.02 AFP ALB BPIFA1 EGFR MUC1

Biological processes related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD protein signal transduction GO:0060395 8.62 AFP HNF4A

Molecular functions related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 8.62 ALB HNF4A

Sources for Hepatoid Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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