MCID: HPT079
MIFTS: 39

Hepatoid Adenocarcinoma

Categories: Cancer diseases, Liver diseases

Aliases & Classifications for Hepatoid Adenocarcinoma

MalaCards integrated aliases for Hepatoid Adenocarcinoma:

Name: Hepatoid Adenocarcinoma 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060534
NCIt 50 C66950
UMLS 70 C1266090

Summaries for Hepatoid Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver.

MalaCards based summary : Hepatoid Adenocarcinoma is related to tubular adenocarcinoma and horseshoe kidney. An important gene associated with Hepatoid Adenocarcinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include colon, lung and pancreas.

Related Diseases for Hepatoid Adenocarcinoma

Diseases related to Hepatoid Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 tubular adenocarcinoma 30.6 MUC1 EGFR CDX2 AFP
2 horseshoe kidney 30.2 EGFR CDX2
3 colorectal adenocarcinoma 30.0 MUC1 EGFR CDX2
4 carcinosarcoma 29.9 MUC1 EGFR CEACAM3
5 viral hepatitis 29.9 SERPINA3 ALB AFP
6 bile duct cancer 29.6 MUC1 EGFR CDX2 ALB AFP
7 endodermal sinus tumor 29.3 SALL4 GPC3 ALB AFP
8 intrahepatic cholangiocarcinoma 29.1 MUC1 GPC3 EGFR CDX2 ALB AFP
9 cholangiocarcinoma 29.0 MUC1 GPC3 EGFR CEACAM3 CDX2 AFP
10 hepatoblastoma 28.8 SERPINA3 SALL4 HNF4A GPC3 AFP
11 bladder hepatoid adenocarcinoma 11.3
12 adenocarcinoma 11.1
13 gastric adenocarcinoma 10.6
14 rare tumor 10.6
15 gallbladder adenocarcinoma 10.5
16 rectum neuroendocrine neoplasm 10.3 CDX2 AFP
17 thymus sarcomatoid carcinoma 10.3 ALB AFP
18 hepatic infarction 10.3 ALB AFP
19 gastric cancer 10.3
20 papillary adenocarcinoma 10.3
21 epididymis adenocarcinoma 10.3 CDX2 AFP
22 epididymis cancer 10.3 CDX2 AFP
23 common bile duct disease 10.3 ALB AFP
24 hepatic coma 10.3 ALB AFP
25 abdominal tuberculosis 10.3 ALB AFP
26 bile duct cysts 10.3 ALB AFP
27 intrahepatic biliary papillomatosis 10.3 MUC1 AFP
28 hepatocellular carcinoma 10.3
29 lung cancer susceptibility 3 10.3
30 bile duct cystadenocarcinoma 10.3 MUC1 AFP
31 colonic lymphangioma 10.3 MUC1 AFP
32 klatskin's tumor 10.3 ALB AFP
33 meckel diverticulum 10.3 CDX2 ALB
34 pancreatic foamy gland adenocarcinoma 10.3 MUC1 CDX2
35 peptic esophagitis 10.3 CDX2 ALB
36 urinary bladder villous adenoma 10.3 MUC1 CDX2
37 biliary tract benign neoplasm 10.3 MUC1 AFP
38 mucinous intrahepatic cholangiocarcinoma 10.3 MUC1 CDX2
39 ethmoid sinus adenocarcinoma 10.3 EGFR CDX2
40 esophageal varix 10.3 ALB AFP
41 bile reflux 10.3 CDX2 ALB
42 glandular cystitis 10.2 MUC1 CDX2
43 malignant peritoneal mesothelioma 10.2 MUC1 EGFR
44 hepatic angiomyolipoma 10.2 CEACAM3 AFP
45 breast scirrhous carcinoma 10.2 MUC1 EGFR
46 malignant exocrine pancreas neoplasm 10.2 MUC1 CDX2
47 hepatic tuberculosis 10.2 ALB AFP
48 appendix disease 10.2 MUC1 CDX2
49 neuroendocrine carcinoma 10.2
50 ovarian benign neoplasm 10.2 MUC1 AFP

Graphical network of the top 20 diseases related to Hepatoid Adenocarcinoma:



Diseases related to Hepatoid Adenocarcinoma

Symptoms & Phenotypes for Hepatoid Adenocarcinoma

Drugs & Therapeutics for Hepatoid Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Hepatoid Adenocarcinoma

Genetic Tests for Hepatoid Adenocarcinoma

Anatomical Context for Hepatoid Adenocarcinoma

MalaCards organs/tissues related to Hepatoid Adenocarcinoma:

40
Colon, Lung, Pancreas, Lymph Node, Spleen, Liver, Small Intestine

Publications for Hepatoid Adenocarcinoma

Articles related to Hepatoid Adenocarcinoma:

(show top 50) (show all 280)
# Title Authors PMID Year
1
Large-scale molecular epidemiological analysis of AAV in a cancer patient population. 61
33782545 2021
2
[Primary hepatoid adenocarcinoma in lung, gallbladder and bladder: a clinicopathological observation of three cases]. 61
33535311 2021
3
Integrated clinicopathologic and immunohistochemical analysis of gastric adenocarcinoma with hepatoid differentiation: an exploration of histogenesis, molecular characteristics and prognostic markers. 61
33636206 2021
4
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature. 61
33367658 2021
5
Hepatoid adenocarcinoma of lung: A diagnostic challenge - Series of six cases with histopathological, predictive molecular and PD.L1 assessment. 61
33433422 2021
6
Hepatoid adenocarcinoma of the lung: An analysis of the Surveillance, Epidemiology, and End Results (SEER) database. 61
33585692 2021
7
[Research progress of prognostic analysis and clinicopathological characteristics of hepatoid adenocarcinoma of the stomach]. 61
33472321 2021
8
AFP-producing Xp11 translocation renal cell carcinoma: Case report and review of the literature. 61
33388149 2020
9
A Unique Case of Alpha-Fetoprotein-Negative Hepatoid Adenocarcinoma of the Stomach With Associated Signet Ring Cell Histological Features and Linitis Plastica. 61
33415058 2020
10
FDG PET/CT of Hepatoid Adenocarcinoma of the Gallbladder. 61
32910054 2020
11
[High-grade Fetal Lung Adenocarcinoma with Hepatoid Adenocarcinoma Component]. 61
33130714 2020
12
Alpha-Fetoprotein-Producing Lung Hepatoid Adenocarcinoma with Brain Metastasis Treated with S-1. 61
33564297 2020
13
Hepatoid adenocarcinoma of the lung and the review of the literature. 61
32041468 2020
14
[Lung Metastasis from Alpha-Fetoprotein Resulting in Esophagogastric Junction Cancer-A Case Report]. 61
33130702 2020
15
Hepatoid adenocarcinoma of the lung accompanied with multiple systemic metastases. 61
32826610 2020
16
The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis. 61
32680468 2020
17
[Metastatic gastrointestinal hepatoid adenocarcinoma of the liver: a high-grade carcinoma that is easily confused with primary hepatocellular carcinoma]. 61
32610383 2020
18
Synchronous Hepatocellular Carcinoma in a Patient with Primary Gastric Cancer: An Exceptional Association. 61
32595434 2020
19
Hepatoid Adenocarcinoma Presenting as Pancreatitis. 61
32607381 2020
20
Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach 61
32442081 2020
21
Hepatoid adenocarcinoma of the lung mimicking metastatic hepatocellular carcinoma. 61
33344280 2020
22
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature. 61
32271611 2020
23
Hepatoid adenocarcinoma of the stomach: Thirteen case reports and review of literature. 61
32258088 2020
24
An alpha-fetoprotein-negative hepatoid adenocarcinoma of the gallbladder with squamous differentiation. 61
32140496 2020
25
[A Case of Metachronous Multiple Liver Metastases of AFP and PIVKA-Ⅱ Producing Gastric Cancer, Responding to Transcatheter Arterial Chemoembolization]. 61
32381975 2020
26
Effect of Immune Checkpoint Inhibitors Plus Chemotherapy on Advanced Gastric Cancer Patients with Elevated Serum AFP or Hepatoid Adenocarcinoma. 61
33173344 2020
27
Anti-PD-1 Therapy Achieved Disease Control After Multiline Chemotherapy in Unresectable KRAS-Positive Hepatoid Lung Adenocarcinoma: A Case Report and Literature Review. 61
32547068 2020
28
Radiotherapy of Pulmonary Hepatoid Adenocarcinoma with Intrahepatic Hemangioma: A Case Report. 61
33239894 2020
29
The Potential Role of Radiotherapy in the Management of Hepatoid Carcinomas of the Stomach: A Case Report. 61
32160618 2020
30
Gastric Hepatoid Adenocarcinoma: Differentiation From Gastric Adenocarcinoma With Dynamic Contrast-Enhanced Computed Tomographic Findings. 61
31490893 2019
31
Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features. 61
30989433 2019
32
Comment on: "Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features. Gastric Cancer, 2019: 1-10" by Wang et al. 61
31444590 2019
33
Hepatoid adenocarcinoma of the renal pelvis in a 59-year-old male with nephrolithiasis: Case report and review of the literature. 61
30683324 2019
34
Hepatoid Adenocarcinoma of the Lung with EGFR Mutation and the Response to Tyrosine Kinase Inhibitors. 61
31558230 2019
35
Pulmonary hepatoid adenocarcinoma. 61
31358339 2019
36
An Adrenal Hepatoid Adenocarcinoma with Left Renal Vein Thrombosis Extending into the Inferior Vena Cava. 61
31478184 2019
37
Gastric adenocarcinoma with enteroblastic differentiation should be differentiated from hepatoid adenocarcinoma: A study with emphasis on clear cells and clinicopathologic spectrum. 61
31301878 2019
38
[A case report of hepatoid adenocarcinoma of the stomach with liver and spleen metastasis misdiagnosed as advanced liver cancer]. 61
31594100 2019
39
Hepatoid adenocarcinoma of the lung. 61
31041840 2019
40
A Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT. 61
30985410 2019
41
Primary hepatoid adenocarcinoma of the lung in Yungui Plateau, China: A case report. 61
31367631 2019
42
Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis. 61
31616755 2019
43
Unsuspected primary malignancy in the setting of elevated serum alpha-fetoprotein. 61
31258434 2019
44
Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature. 61
30946350 2019
45
Hepatoid Adenocarcinoma With Enteroblastic Differentiation in the Sigmoid Colon: Lessons From a Rare Case. 61
30848729 2019
46
Oesophageal hepatoid carcinoma with liver metastasis, a diagnostic dilemma. 61
31025640 2019
47
Hepatoid adenocarcinoma of fallopian tube: A case report and review of the literature. 61
30882620 2019
48
The HDAC Inhibitor, SAHA, Combined with Cisplatin Synergistically Induces Apoptosis in Alpha-fetoprotein-producing Hepatoid Adenocarcinoma Cells. 61
30923410 2019
49
Hepatoid adenocarcinoma in the peritoneal cavity: Two case reports. 61
30702578 2019
50
Genomic Profiles of a Patient of Pulmonary Hepatoid Adenocarcinoma With High AFP Level: A Case Report. 61
31921629 2019

Variations for Hepatoid Adenocarcinoma

Cosmic variations for Hepatoid Adenocarcinoma:

9 (show top 50) (show all 15388)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM97724722 ZXDB liver,NS,carcinoma,hepatocellular carcinoma c.1308C>A p.D436E 23:57593356-57593356 3
2 COSM94430614 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
3 COSM94436083 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
4 COSM94063771 ZSCAN20 liver,NS,carcinoma,hepatocellular carcinoma c.2314G>T p.G772W 1:33494658-33494658 3
5 COSM88264637 ZRSR2 liver,NS,carcinoma,hepatocellular carcinoma c.304G>T p.E102* 23:15803788-15803788 3
6 COSM102741209 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.859A>G p.M287V 22:29049340-29049340 3
7 COSM131494492 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.1159A>G p.M387V 22:29049340-29049340 3
8 COSM103081572 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.859A>G p.M287V 22:29049340-29049340 3
9 COSM95977701 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
10 COSM102131817 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
11 COSM95960776 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
12 COSM113317148 ZNF853 liver,NS,carcinoma,hepatocellular carcinoma c.1610G>T p.G537V 7:6622601-6622601 3
13 COSM99592496 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.829T>A p.F277I 19:36891962-36891962 3
14 COSM128686611 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.1072T>A p.F358I 19:36891962-36891962 3
15 COSM123358576 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.691C>T p.L231= 4:145885684-145885684 3
16 COSM123949383 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581= 4:145885684-145885684 3
17 COSM101741672 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581= 4:145885684-145885684 3
18 COSM86004822 ZNF653 liver,NS,carcinoma,hepatocellular carcinoma c.1553A>C p.H518P 19:11485673-11485673 3
19 COSM98561269 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
20 COSM142353152 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
21 COSM142221290 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
22 COSM99854658 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.156G>A p.V52= 19:52002156-52002156 3
23 COSM139729931 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
24 COSM141470046 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
25 COSM141819438 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
26 COSM145038099 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
27 COSM91868668 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.3900G>T p.K1300N 19:30557161-30557161 3
28 COSM91880764 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.2171-78T>G p.? 19:30534769-30534769 3
29 COSM140721836 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.2998+205G>A p.? 18:25194955-25194955 3
30 COSM131506983 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.3658+205G>A p.? 18:25194955-25194955 3
31 COSM94799980 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.3658+205G>A p.? 18:25194955-25194955 3
32 COSM90582798 ZNF518B liver,NS,carcinoma,hepatocellular carcinoma c.1624G>T p.E542* 4:10444705-10444705 3
33 COSM87577038 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.6715G>T p.V2239L 9:106974156-106974156 3
34 COSM109096265 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.3433G>T p.V1145L 9:106974156-106974156 3
35 COSM104985080 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.298+23785G>T p.? 2:179745718-179745718 3
36 COSM104427909 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.20G>T p.S7I 2:179745718-179745718 3
37 COSM151538615 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.253+23785G>T p.? 2:179745718-179745718 3
38 COSM127708351 ZNF345 liver,NS,carcinoma,hepatocellular carcinoma c.47-856A>T p.? 19:36891962-36891962 3
39 COSM135887725 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1168C>G p.L390V 16:89734008-89734008 3
40 COSM84511025 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1219C>G p.L407V 16:89734008-89734008 3
41 COSM111609487 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1444C>G p.L482V 16:89734008-89734008 3
42 COSM92353291 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.1010C>T p.T337I 12:133010889-133010889 3
43 COSM130415812 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.950C>T p.T317I 12:133010889-133010889 3
44 COSM88697750 ZNF217 liver,NS,carcinoma,hepatocellular carcinoma c.*194A>T p.? 20:53569094-53569094 3
45 COSM95253159 ZNF217 liver,NS,carcinoma,hepatocellular carcinoma c.*194A>T p.? 20:53569094-53569094 3
46 COSM94505616 ZMYND12 liver,NS,carcinoma,hepatocellular carcinoma c.425-1G>T p.? 1:42440026-42440026 3
47 COSM89943752 ZMYM4 liver,NS,carcinoma,hepatocellular carcinoma c.86-8201G>T p.? 1:35350724-35350724 3
48 COSM101398456 ZIC2 liver,NS,carcinoma,hepatocellular carcinoma c.-18C>T p.? 13:99982047-99982047 3
49 COSM113521587 ZGPAT liver,NS,carcinoma,hepatocellular carcinoma c.*197C>A p.? 20:63736116-63736116 3
50 COSM94679661 ZGPAT liver,NS,carcinoma,hepatocellular carcinoma c.*197C>A p.? 20:63736116-63736116 3

Expression for Hepatoid Adenocarcinoma

Search GEO for disease gene expression data for Hepatoid Adenocarcinoma.

Pathways for Hepatoid Adenocarcinoma

Pathways related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 CDX2 ALB AFP
2 10.44 HNF4A ALB AFP

GO Terms for Hepatoid Adenocarcinoma

Cellular components related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 SERPINA3 MUC1 GPC3 EGFR BPIFA1 ALB

Biological processes related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 8.96 ALB AFP
2 anterior/posterior axis specification GO:0009948 8.62 GPC3 CDX2

Molecular functions related to Hepatoid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 8.8 HNF4A ALB AFP

Sources for Hepatoid Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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